Trimer of Asn-Gly-Pro, its preparation and application

CN118620088BActive Publication Date: 2025-07-29CAPITAL UNIVERSITY OF MEDICAL SCIENCES

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Patent Information

Application Number: CN202410803928.7
Authority / Receiving Office: CN · China
Patent Type: Patents(China)
Current Assignee / Owner
Filing Date: 2024-06-20
Publication Date: 2025-07-29
Estimated Expiration: 2044-06-20

Application Information

Patent Timeline

20 Jun 2024

Application

CN202410803928.7

29 Jul 2025

Publication

CN118620088B

IPC: C07K19/00; C07K5/093; C07K1/02; C07K1/16; A61K38/06; A61P7/02

CPC: C07K19/00; C07K5/0819; A61P7/02; A61K38/00

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Application Domain

Tripeptide ingredients Peptide preparation methods

Technology Topics

Disease Venous blood

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AI Technical Summary

Benefits of technology

[0013] The present invention provides a trimer composed of three Asn-Gly-Pro molecules through non-covalent bonds, namely [Asn-Gly-Pro]3. Through experiments, it is proved that the [Asn-Gly-Pro]3 of the present invention not only has a good anti-venous thrombosis effect, but also the anti-venous thrombosis effect is significantly stronger than that of Asn-Gly-Pro. Therefore, it is proposed that the present invention provides an effective technical measure for the field of drugs for inhibiting venous thrombosis.

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Abstract

The present invention discloses a trimer of Asn-Gly-Pro, namely [Asn-Gly-Pro]3, discloses its preparation method and its application in the treatment of venous thrombotic diseases. Experiments have proved that [Asn-Gly-Pro]3 of the present invention not only has a good anti-venous thrombosis effect, but also the anti-venous thrombosis effect is significantly stronger than that of Asn-Gly-Pro. Therefore, it is proposed that the present invention provides an effective technical means for anti-venous thrombosis.

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