Composition with moisturizing, soothing, wrinkle resisting, tightening, whitening, oil controlling and repairing effects and application thereof

Abstract

The invention relates to a composition with moisturizing, soothing, wrinkle resisting, tightening, whitening, oil controlling and repairing effects and application thereof. The composition is prepared from the following raw material components in parts by weight: 0.01 to 1 part of sodium mannose phosphate, 0.3 to 3 parts of inositol, 0.3 to 3 parts of ribose, 1 to 10 parts of taurine and 30 to 97 parts of thiotaurine. Compared with the prior art, the composition has the advantages that five components, namely the sodium mannose phosphate, the inositol, the ribose, the taurine and the thiotaurine, are synergistically compounded, so that the effects of moisturizing, relieving, resisting wrinkles, tightening, whitening, controlling oil, repairing and the like can be effectively balanced and optimized, and high-value application in the field of daily cosmetics is realized.

Description

Technical Field

[0001] The invention belongs to the technical field of daily chemical products, and relates to a composition with moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repairing effects and application thereof. Background Art

[0002] Aging is a natural law of human growth and cannot be prevented artificially, but by analyzing the causes of skin aging, we can replenish moisture and nutrition to the skin in a targeted manner and resist external damage, thereby effectively delaying aging and having young and healthy skin.

[0003] There are many functional raw materials used for skin anti-aging, mainly divided into skin renewal (representative raw materials: Pitera, bifid yeast cell solution extract, salicylic acid, etc.), chemical antioxidants (representative raw materials: ergothioneine, SOD, vitamin E, etc.), plant antioxidants (herbal, representative brands Herborist, Shiseido, etc.), collagen supplements (representative raw materials: retinol, ubiquinone, hydrolyzed collagen), anti-glycation (representative raw materials: carnosine, lipoic acid, ferulic acid, resveratrol, etc.), etc. However, these anti-aging products have little effect on improving skin repair and oil control.

[0004] At the same time, the anti-wrinkle and anti-aging products currently on the market have various defects such as unclear effects and / or poor permeability. Therefore, it is very important to provide products that have obvious effects in repair, anti-wrinkle and oil control. Summary of the invention

[0005] The purpose of the present invention is to provide a composition with moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repairing effects, which has a comprehensive and balanced excellent effect in terms of moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repairing effects.

[0006] The purpose of the present invention can be achieved by the following technical solutions:

[0007] In one aspect, the present invention provides a composition with moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repairing effects, which comprises the following raw material components in parts by weight: 0.01-1 parts of sodium mannose phosphate, 0.3-3 parts of inositol, 0.3-3 parts of ribose, 3-10 parts of taurine, and 30-97 parts of thiotaurine.

[0008] Furthermore, the composition formula of the present invention may include the following raw material components in parts by weight: 0.1-1 parts of sodium mannose phosphate, 1-3 parts of inositol, 0.3-3 parts of ribose, 3-10 parts of taurine, and 30-70 parts of thiotaurine.

[0009] Furthermore, the composition formula of the present invention may include the following raw material components in parts by weight: 0.3-0.6 parts of sodium mannose phosphate, 1-2 parts of inositol, 0.3-3 parts of ribose, 5-8 parts of taurine, and 40-60 parts of thiotaurine.

[0010] In a second aspect, the present invention provides a composition having moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repairing effects for use in the preparation of cosmetics.

[0011] Furthermore, the cosmetic is essence, essence water, facial mask, cream product, gel, facial cleanser or shower gel.

[0012] Furthermore, when the cosmetic is an essence, the added amount of the composition is 0.5 to 1.5 wt %.

[0013] More preferably, the essence further includes the following raw material components in weight percentage: 4-6% glycerol, 0.2-0.3% carbomer, 0.02-0.04% disodium EDTA, 0.4-0.6% 1,2-hexanediol, 0.4-0.6% p-hydroxyacetophenone, 0.15-0.25% tromethamine, 0.08-0.12% sodium di(laurylamide glutamine) lysine, 1.5-2.5% 1,3-propylene glycol, 0.8-1.2% methyl gluceth-20, 0.008-0.012% citric acid, 0.06-0.1% sodium citrate, and the rest is supplemented with water to 100%.

[0014] More preferably, the essence is prepared by the following method:

[0015] (1) water, glycerin, carbomer, disodium EDTA, 1,2-hexanediol, p-hydroxyacetophenone, and tromethamine as phase A, tromethamine and methyl gluceth-20 as phase B, sodium di(laurylamide glutamine) lysine, citric acid, and sodium citrate as phase C, and the combination as phase D;

[0016] (2) Stirring the components in phase A at high speed, heating them and dispersing them evenly;

[0017] (3) After cooling down once, add phase B and stir evenly;

[0018] (4) After the second cooling, add the components in phase C in sequence, stir evenly, and adjust the pH value to between 5.5 and 7.0;

[0019] (5) Finally, add phase D and stir well.

[0020] More preferably, in step (2), the heating temperature is 80-85°C.

[0021] More preferably, in step (3), the temperature of the first cooling is 60-65°C;

[0022] In step (4), the temperature of the secondary cooling is below 45°C.

[0023] Compared with the prior art, the present invention can effectively alleviate redness, and has excellent moisturizing, anti-wrinkle and oil control effects through the synergistic compounding of five components: sodium mannose phosphate, inositol, ribose, taurine and thiotaurine, thereby achieving high-value application in the field of daily cosmetics. DETAILED DESCRIPTION

[0024] The present invention is described in detail below in conjunction with specific embodiments. This embodiment is implemented based on the technical solution of the present invention, and provides a detailed implementation method and a specific operation process, but the protection scope of the present invention is not limited to the following embodiments.

[0025] In the following examples, unless otherwise specified, raw materials or processing techniques are conventional commercially available raw materials or conventional processing techniques in the art.

[0026] Embodiment 1-5:

[0027] The present embodiment provides a composition with moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repair effects, named "Energy Factor", which includes the following raw material components in parts by weight: 0.01-1 part of sodium mannose phosphate, 0.3-3 parts of inositol, 0.3-3 parts of ribose, 3-10 parts of taurine, and 30-97 parts of thiotaurine.

[0028] Based on the formula of the above composition, the present invention provides a series of embodiments and comparative examples with different proportions, as shown in Table 1.

[0029] Table 1 Formula design of embodiments and comparative examples

[0030]

[0031] Taking Example 1 as an example, the effects of the cosmetic composition in terms of moisturizing, soothing, anti-wrinkle and firming, whitening, oil control, and repair were measured.

[0032] (1) Composition Moisture Test

[0033] The present invention uses Example 1 as the sample group to test the moisturizing property of the composition. The specific data is obtained by referring to the test report issued by a third-party testing agency (Noah Testing Technology Co., Ltd.) on July 22, 2024 in accordance with the "Testing Operation Guidelines for Cosmetic Moisturizing Efficacy (Weight Method)".

[0034] Test method:

[0035] Each test group was set up with 3 parallels, and a negative control group using pure water and a positive control group using glycerol were set up. The operation steps were consistent with the sample test group (i.e., Example 1):

[0036] 1. Take a dry stoppered glass weighing bottle and place it in a suitable 25℃ dryer one day before the experiment, and accurately weigh its weight (m0);

[0037] 2. Take 1 mL of nutrient agar at room temperature and put it into a weighing bottle. After solidification, add 200 μL of the test sample and accurately weigh its mass (m1);

[0038] 3. Place in a desiccator containing desiccant for a total of t = 8h;

[0039] 4. For the sample group and the control group, take out the weighing bottle from the desiccator every 2h, 4h, 6h, and 8h, cover the weighing bottle lid, and accurately weigh its weight m t ;

[0040] 5. Moisture retention is evaluated by the percentage of weight loss after drying, and the calculation formula is:

[0041]

[0042] The changes in the percentage of weight loss between the sample group and the control group are shown in the following table.

[0043]

[0044] It can be seen from the table that the weight loss percentage of the sample group in each time period is lower than that of the negative control, indicating that the sample (Example 1) has a better moisturizing effect.

[0045] (2) Composition soothing test

[0046] The present invention tests the soothing effect of the composition through a hyaluronidase inhibition test, and specifically evaluates the anti-allergic activity of the composition sample by taking the hyaluronidase inhibition rate as an indicator. The greater the hyaluronidase inhibition rate, the stronger the soothing property. The performance data is obtained by a test report issued on July 22, 2024 by a third-party testing agency (Noah Testing Technology Co., Ltd.) in accordance with the "Cosmetic Soothing (Hyaluronidase Inhibition Rate) Test Operation Guide".

[0047] The specific detection methods are as follows:

[0048] In addition to the sample group of Example 1, a negative control group (pure water) and a positive control group (VC) were also set up.

[0049] Reagent raw materials: 1000U / mL hyaluronidase solution, 0.5mg / mL sodium hyaluronate solution, pH=5.6 acetate buffer solution, acetylacetone solution (50mL 1mol / L sodium carbonate solution and 3.5mL acetylacetone mixed evenly), P-DAB color developer (0.8g p-dimethylaminobenzaldehyde dissolved in 15mL concentrated hydrochloric acid and 15mL anhydrous ethanol mixed evenly), calcium chloride solution 2.5mol / L, sodium hydroxide solution 5mol / L.

[0050] The experimental design method is as follows:

[0051] The sample group and the positive control group diluted with pure water according to certain requirements were added with various components according to Table 2 below, where:

[0052] Tube Ⅰ-sample group, tube Ⅱ-sample blank control group; tube Ⅲ-positive group, tube Ⅳ-positive blank control group; tube Ⅴ-negative group, tube Ⅵ-negative blank control group.

[0053] Table 2

[0054]

[0055]

[0056]

[0057] Wherein, A is the OD value of the solution in wells Ⅰ and Ⅲ; B is the OD value of the solution in wells Ⅱ and Ⅳ; C is the OD value of the solution in well V; D is the OD value of the solution in well VI.

[0058] The hyaluronidase inhibition rate results of the above sample groups and the control group are shown in Table 3 below.

[0059] Table 3

[0060]

[0061] Combined with the data in the above table, it can be seen that the hyaluronidase inhibition rate of the composition sample of the present invention is about 79.5%, and P<0.05 has a significant difference. Therefore, it can be considered that the composition sample of the present invention has an inhibitory effect on hyaluronidase and thus has a soothing effect.

[0062] (3) Anti-wrinkle and firming efficacy test

[0063] The present invention uses a biochemical method-elastase inhibition test model to detect the effect of the sample on enzyme activity inhibition, and evaluates the anti-wrinkle and firming efficacy of the sample group taking Example 1 as an example. The performance data is obtained by a third-party testing agency (Noah Testing Technology Co., Ltd.) according to the "Cosmetic Anti-Wrinkle and Firming (Elastase Inhibition Rate) Test Operation Guide" issued on May 28, 2024.

[0064] The specific detection methods are as follows:

[0065] In addition to the sample group of Example 1, a negative control group (pure water) and a positive control group (VC) were also set up.

[0066] Test materials:

[0067] TESCA buffer solution: Prepare 40g / L calcium chloride solution with grade 3 water, take 0.1mL calcium chloride solution and 10mL 10×TES solution (pH7.5) and mix them, adjust the pH to 8.0 with 5mol / L sodium hydroxide and make up to 100mL;

[0068] Elastase, 2 U / mL;

[0069] MAAPVN (i.e. "MeOSuc-AAPV-pNA", Chinese name N-methoxysuccinyl-propionyl-propionyl-prolyl-valine p-nitroanilide) solution, 10mmol / L, is a sensitive fluorescent substrate for human leukocytes and porcine pancreatic elastase.

[0070] The experimental design method is as follows:

[0071] The sample was diluted with TESCA buffer solution, and then the components were added according to Table 4 below, divided into test group in well 1: sample group, positive control group, test control blank group in well 2, negative control group in well 3, and negative control blank group in well 4. At the end of the test, the reaction solution was transferred to the corresponding 96-well plate, with 3 parallels in each group. At the end of the reaction, the reading (OD value) was read at 410 nmm with an ELISA reader.

[0072] Table 4

[0073]

[0074]

[0075] Wherein, A-OD value of the sample solution in well 1; B-OD value of the sample solution in well 2; C-OD value of the sample solution in well 3; D-OD value of the sample solution in well 4.

[0076] The results of the elastase inhibition rates of the above sample groups and the control group are shown in Table 5 below.

[0077] Table 5

[0078]

[0079] Combined with the data in the above table, it can be seen that the elastase inhibition rate of the sample of Example 1 of the present invention is about 67%, P<0.05 has a significant difference. Therefore, it can be considered that the composition sample of the present invention has inhibitory effect on elastase and has anti-wrinkle and firming effects.

[0080] (4) Whitening efficacy test

[0081] The present invention determines the whitening efficacy of the composition sample through a tyrosinase activity inhibition test, and the performance data is obtained by a third-party testing agency (Shanghai PONY Testing Group Co., Ltd.) based on the tyrosinase activity inhibition test and the test report issued on August 13, 2024.

[0082] The specific test methods are as follows:

[0083] Experimental materials:

[0084] Phosphate buffer, pH 6.8; mushroom tyrosinase solution 125U / mL; L-tyrosine solution 0.03wt%; arbutin, 0.5mg / mL; the effective concentration of the sample group is 0.3mg / mL, which can be diluted to the test concentration with pure water as needed.

[0085] Test steps: Take the sample solution, add phosphate buffer solution and tyrosine solution, incubate at 37℃ for 10min, add tyrosinase substrate solution, react at 37℃ for 20min, and immediately measure the absorbance at 490nm with an enzyme reader. Arbutin is used as the positive control group, and 3 parallel samples are measured for each test group.

[0086] The data were statistically processed using professional software, and the t-test was used to compare statistical differences. P < 0.05 was considered to be statistically significant, * represents P < 0.05, ** represents P < 0.01, and *** represents P < 0.001.

[0087] The test results are shown in Table 6 below. The experimental results show that the positive control group arbutin has a significant tyrosinase inhibitory effect at a concentration of 0.3 mg / mL and 0.15 mg / mL, proving that the model is effective. The sample group of the present invention (i.e., Example 1) has a significant tyrosinase inhibitory effect at both 0.3 mg / mL and 0.15 mg / mL, and has a whitening effect.

[0088] Table 6 Tyrosinase inhibition rate and difference significance analysis

[0089] Experimental Group concentration Inhibition rate SD P-value Significance Blank control - 0.00％ 1.59％ 1.00000 - Positive Control-Arbutin 0.3mg / mL 61.72％ 5.30％ 0.00004 *** sample 0.3mg / mL 59.81％ 2.30％ 0.00000 *** Positive Control-Arbutin 0.15mg / mL 29.56％ 5.08％ 0.00065 *** sample 0.15mg / mL 37.25％ 5.85％ 0.00150 **

[0090] (5) Oil control efficacy test

[0091] The present invention evaluates the oil control efficacy of the composition sample through the 5α-reductase inhibition rate test method. The specific performance results are obtained by a third-party testing agency (Noah Testing Technology Co., Ltd.) based on the oil control 5α-reductase inhibition rate method and the test report issued on July 16, 2024. Finasteride (0.5 mg / mL) is set as the positive control group, and the sample diluent is used as the negative control group.

[0092] The specific method is:

[0093] 1. Take out the required strips from the aluminum foil bag after equilibration at room temperature for 20 minutes, and seal the remaining strips with a ziplock bag and return them to 4°C.

[0094] 2. Sample addition: set up a blank control group, a negative control group, and a sample group (i.e., Example 1), with 3 parallel wells in each group. Except for the blank control group, no reagent was added. In each well of the other groups, 25 μL of 20 U / mL 5α-reductase standard was first added. Then, the negative control group was added with sample diluent, the positive control group was added with 0.5 mg / mL finasteride, and the sample group was added with samples in an amount of 25 μL. The samples were incubated in a 37° C. thermostatic reactor for 60 min.

[0095] 3. Discard the liquid, pat dry with absorbent paper, fill each well with washing solution, let it stand for 1 minute, shake off the washing solution, pat dry, and repeat this washing process 5 times.

[0096] 4. Except for the blank control group, 100 μL of horseradish peroxidase (HRP)-labeled detection antibody was added to each well of the other groups, the reaction wells were sealed with sealing film, and incubated in a 37°C constant temperature reactor for 60 min.

[0097] 5. Discard the liquid, pat dry with absorbent paper, fill each well with washing solution, let it stand for 1 minute, shake off the washing solution, pat dry with absorbent paper, and repeat this 5 times.

[0098] 6. Add 100 μL of the mixture of color developing solution A and B to each well and incubate at 37°C in the dark for 15 min.

[0099] 7. Add 50 μL of stop solution to each well and measure the OD value of each well at a wavelength of 450 nm within 15 minutes.

[0100] 5α-reductase inhibition rate calculation formula:

[0101]

[0102] The experimental results of the present invention are shown in Table 7. It can be seen from the table that the 5α-reductase inhibition rate of the sample group using Example 1 is 39.1%, P<0.05, which is significantly different from that of the negative control group, indicating that the sample has an oil control effect.

[0103] Table 7

[0104]

[0105] (6) Repair efficacy test

[0106] Due to the proliferation and differentiation of human keratinocytes, the skin barrier is formed by orderly assembly. When the assembly process is disordered, the skin barrier function will be damaged. The skin barrier damage can be repaired by regulating the proliferation and differentiation of keratinocytes. The present invention detects the changes in cell proliferation after the test substance acts, evaluates its ability to promote cell proliferation, and is used for the evaluation of the repair, regeneration, maintenance and healing of functional raw materials and products.

[0107] The experimental results were obtained by a third-party testing agency (Noah Testing Technology Co., Ltd.) based on the "Repair (Human Keratinocyte (HaCaT) Proliferation) Test Operation Instructions" and the test report issued on June 18, 2024. The specific testing methods are as follows:

[0108] In addition to the sample group of Example 1, a negative control group (human keratinocytes + DMEM basal medium) and a positive control group (human keratinocytes + hEGF) were also set up.

[0109] Experimental materials:

[0110] Human keratinocytes HaCaT; DMEM medium; fetal bovine serum; 0.25% trypsin; hEGF; MTT thiazolyl blue.

[0111] 1. Cell activity test: Collect cells in the logarithmic growth phase, adjust the cell density and inoculate them into 96-well plates, with each well containing 10 μL of culture medium. After culturing in a CO2 cell culture incubator for 24 hours, remove the culture medium, wash the cells twice with PBS buffer, and then group and administer the drugs according to the sample configuration concentration below.

[0112]

[0113] 2. Grouping:

[0114]

[0115] 3. Drug administration: After drug addition, the cells were cultured in a CO2 cell culture incubator for 24 h, and then an MTT cell viability test was performed. The absorbance OD value was read at 490 nm and the cell survival rate was calculated. Only cell culture medium was added to the blank wells.

[0116] 4. Cell proliferation detection: Adjust to a certain cell density, re-spread 3 96-well plates and add samples at a sample concentration with cell viability ≥ 90% in the same group. After adding samples, place in the incubator and culture for 0h, 24h, and 48h, perform MTT cell viability detection at the same time, and calculate the relative cell proliferation rate at 0h, 24h, and 48h.

[0117] The measured experimental results are shown in Tables 8 and 9 below.

[0118] Table 8 Cell viability test results

[0119]

[0120]

[0121] Table 9 Cell relative proliferation rate test results

[0122]

[0123]

[0124] As can be seen from the above table, the sample group of the present invention has a growth-promoting effect on Hacat cells and has a maintenance effect.

[0125] In order to further highlight the synergistic effect of the composition provided by the present invention on skin care effects, the compositions of the above-mentioned Examples 1-5 and Comparative Examples 1-5 were continued to be added in an amount of 1% (i.e., 0.01) to prepare essences and conduct tests. The formula of the essences is shown in Table 10 below.

[0126] Table 10

[0127]

[0128] A total of 11 groups of different volunteer groups (5 groups) were selected, and each group selected 2 people with neutral skin, 1 person with dry skin, 1 person with oily skin, and 1 person with mixed skin. The essence of the embodiment group and the essence of the comparative example group were prepared and tested separately. According to the group numbers AJ, the corresponding comparison objects of each experimental group were: experimental group A was embodiment 1 and the blank group, experimental group B was embodiment 2 and the blank group, experimental group C was embodiment 3 and the blank group, experimental group D was embodiment 4 and the blank group, experimental group E was embodiment 5 and the blank group, experimental group F was embodiment 1 and comparative example 1, experimental group G was embodiment 1 and comparative example 2, experimental group H was embodiment 1 and comparative example 3, experimental group I was embodiment 1 and comparative example 4, and experimental group J was embodiment 1 and comparative example 5.

[0129] Volunteer testing standard: T-CAB 0152-2022.

[0130] Volunteer application method and dosage: Wash the face before use, moisturize appropriately, and then apply this product and the blank group or control group as a control to the left and right half of the face respectively, apply evenly to ensure that every part of the skin can absorb the material. Use twice a day, once in the morning and once in the evening, for 28 days.

[0131] The test intervals for volunteers were: 0d, 14d, and 28d.

[0132] Volunteer test indicators and instruments: Elasticity (firmness), redness (soothing), and transepidermal water loss (repair) tests were conducted on the left and right eye corners and the highest points of the left and right cheekbones, and sebum secretion (oil control) test was conducted on the forehead. The instruments used were Antera 3D camera from Miravex Limited, Vapometer (transepidermal water loss rate tester) from Delfin Technologies, MPA6 (skin oil multi-probe tester, SM 815) from Courage+Khazaka, and ElastiMeter (elasticity tester) from Delfin Technologies.

[0133] Each test indicator:

[0134] Redness value: This value reflects the sensitivity and damage of the skin. It is directly tested and read by the Antera 3D camera and the supporting dedicated software. The larger the value, the more damaged it is. The instant value and the total value are the improvement rate. The calculation formula is:

[0135]

[0136] Where A0 is the redness value of the volunteer on day 0 (i.e. before the test), A t is the redness value of the volunteer at time t.

[0137] Elasticity index: This value reflects the change in skin elasticity and is directly measured and read by ElastiMeter (elasticity tester). The larger the value, the better the elasticity and the better the firming effect. The instant value and the total value are the improvement rate. The calculation formula is:

[0138]

[0139] Where B0 is the elasticity index of the volunteer on day 0 (i.e. before the test), B t is the resilience index of the volunteer at time t.

[0140] Oil secretion value: This value reflects the change of skin oil. It is the value of sebum secretion read by MPA6 (skin oil multi-probe tester, SM 815). The smaller the value, the better the oil control effect. The instant value and the total value are the improvement rate. The calculation formula is:

[0141]

[0142] Where, C0 is the oil secretion value of the volunteers on day 0 (i.e. before the test), C t is the oil secretion value of the volunteer at time t.

[0143] Transepidermal water loss (ie twel): This value reflects the water loss value, which is obtained by Vapometer (transepidermal water loss rate tester). The smaller the value itself, the better. The instant value and the total value are the improvement rate. The calculation formula is:

[0144]

[0145] Where D0 is the transepidermal water loss value of the volunteers on day 0 (i.e. before the test), D t is the transepidermal water loss value of the volunteers at time t.

[0146] Test results:

[0147] The experimental results of experimental groups A to J are shown in Table 11 below.

[0148] Table 11

[0149]

[0150]

[0151] It can be seen from the data in Table 11 above that the essence using the composition of the present invention has obvious improvements in redness, elasticity, sebum secretion, moisturizing, etc. compared with the blank group, which shows that the composition of the present invention has a targeted, broad, simple and safe skin care effect.

[0152] Comparing Example 1 with Comparative Examples 1 to 5, it can be seen that when sodium mannose phosphate is not added, the anti-wrinkle property is greatly reduced, and at the same time, the repair, moisturizing and oil control properties are also reduced to a certain extent; when inositol is not added, the oil control is greatly reduced, and at the same time, the repair, anti-wrinkle, moisturizing and other aspects are also reduced to varying degrees; when ribose is not added, the repair and moisturizing properties are greatly reduced, and the anti-wrinkle and oil control effects are also reduced to a certain extent; when taurine is not added, the moisturizing and repair properties are greatly reduced, and the anti-wrinkle and oil control effects are also reduced to a certain extent; when thiotaurine is not added, the changes are similar to those without adding sulfuric acid, but the repair and anti-wrinkle effects are more reduced.

[0153] It can be seen from the above that the five components in the composition of the present invention have a synergistic effect with each other, so that the composition can have significant improvements in moisturizing, soothing, anti-wrinkle and oil control at the same time, and the five components are indispensable.

[0154] Similarly, by comparing Example 1 with Examples 2 to 5, it is found that compared with Example 1, in Example 2, by significantly increasing the amount of thiotaurine and reducing the amounts of the other four ingredients, although the repair and moisturizing effects can be maintained at a considerable level, the anti-wrinkle and oil control effects have a certain degree of decline; in Example 3, by reducing the amounts of thiotaurine and ribose and increasing the amounts of the other three ingredients, the anti-wrinkle and oil control effects can be maintained at a considerable level, but the repair and moisturizing effects have a significant decline; in Example 4, by increasing the amounts of inositol, taurine, and thiotaurine and reducing the amounts of the other two ingredients, the moisturizing and oil control effects can be maintained at a considerable level, but the repair and anti-wrinkle effects have a more significant decline; in Example 5, by increasing the amounts of sodium mannose phosphate, inositol, and ribose, the other two ingredients remain unchanged, and the effects of repair, moisturizing, anti-wrinkle and oil control do not change much.

[0155] The above description of the embodiments is to facilitate the understanding and use of the invention by those skilled in the art. It is obvious that those skilled in the art can easily make various modifications to these embodiments and apply the general principles described herein to other embodiments without creative work. Therefore, the present invention is not limited to the above embodiments, and improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the present invention should be within the scope of protection of the present invention.

Claims

1. A composition having moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repairing effects, characterized in that: The invention comprises the following raw material components in parts by weight: 0.01-1 part of sodium mannose phosphate, 0.3-3 parts of inositol, 0.3-3 parts of ribose, 1-10 parts of taurine and 30-97 parts of thiotaurine.

2. A composition with moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repairing effects according to claim 1, characterized in that: The invention comprises the following raw material components in parts by weight: 0.1-1 parts of sodium mannose phosphate, 1-3 parts of inositol, 0.3-3 parts of ribose, 3-10 parts of taurine and 30-70 parts of thiotaurine.

3. A composition with moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repairing effects according to claim 1, characterized in that: The invention comprises the following raw material components in parts by weight: 0.3-0.6 parts of sodium mannose phosphate, 1-2 parts of inositol, 0.3-3 parts of ribose, 5-8 parts of taurine and 40-60 parts of thiotaurine.

4. Use of a composition having moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repairing effects as claimed in any one of claims 1 to 3 in the preparation of cosmetics.

5. The use of the composition with moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repairing effects according to claim 4, characterized in that: The cosmetics are essence, essence water, facial mask, cream product, gel, gel, facial cleanser, shower gel or shampoo.

6. The use of the composition with moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repairing effects according to claim 5, characterized in that: When the cosmetic is an essence, the added amount of the composition is 0.5 to 1.5 wt %.

7. The use of the composition with moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repairing effects according to claim 6, characterized in that: The essence also includes the following raw material components in weight percentage: 4-6% glycerol, 0.2-0.3% carbomer, 0.02-0.04% disodium EDTA, 0.4-0.6% 1,2-hexanediol, 0.4-0.6% p-hydroxyacetophenone, 0.15-0.25% tromethamine, 0.08-0.12% sodium di(laurylamide glutamine) lysine, 1.5-2.5% 1,3-propylene glycol, 0.8-1.2% methyl gluceth-20, 0.008-0.012% citric acid, 0.06-0.1% sodium citrate, and the rest is supplemented with water to 100%.

8. The use of the composition having moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repairing effects according to claim 7, characterized in that: The essence is prepared by the following method: (1) water, glycerin, carbomer, disodium EDTA, 1,2-hexanediol, p-hydroxyacetophenone, and tromethamine as phase A, tromethamine and methyl gluceth-20 as phase B, sodium di(laurylamide glutamine) lysine, citric acid, and sodium citrate as phase C, and the combination as phase D; (2) Stirring the components in phase A at high speed, heating them and dispersing them evenly; (3) After cooling down once, add phase B and stir evenly; (4) After the second cooling, add the components in phase C in sequence, stir evenly, and adjust the pH value to between 5.5 and 7.0; (5) Finally, add phase D and stir well.

9. The use of the composition with moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repairing effects according to claim 8, characterized in that: In step (2), the heating temperature is 80-85°C.

10. The use of the composition with moisturizing, soothing, anti-wrinkle, firming, whitening, oil control and repairing effects according to claim 8, characterized in that: In step (3), the temperature of the first cooling is 60-65°C; In step (4), the temperature of the secondary cooling is below 45°C.

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