Preparation method and application of an umbilical cord extract
By optimizing the enzymatic lysis process using trypsin mutants, the problem of low enzymatic lysis efficiency of umbilical cord extracts in the prior art was solved, and the prepared extracts showed significant acceleration effects in skin repair.
CN119302994BActive Publication Date: 2025-07-22广州博士派生物科技有限公司
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Patent Information
- Application Number
- CN202411341809.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-25
- Publication Date
- 2025-07-22
- Estimated Expiration
- 2044-09-25
AI Technical Summary
Technical Problem
In the prior art, the enzymatic method of animal umbilical cord extract is inefficient and complicated, resulting in a low extraction rate and poor effect.
Method used
The animal umbilical cord was enzymatically dissolved by trypsin mutants, including homogenization, stirring, centrifugation, inactivation, filtration, ultrafiltration and lyophilization, and the enzymatic lysis process was optimized to improve the activity and stability of the extract.
Benefits of technology
The enzymatic lysis efficiency was improved, and the prepared umbilical cord extract significantly accelerated the skin repair effect in the mouse burn model, and completely healed 2 days in advance, which was better than the ordinary method.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention relates to the technical field of animal umbilical cord extraction, and particularly relates to a preparation method and application of an animal umbilical cord extract. By using a trypsin mutant to prepare the umbilical cord extract, the present invention not only improves the enzymatic hydrolysis efficiency, but also the obtained umbilical cord extract is significantly superior to ordinary enzymolysis products in terms of skin repair effect. In the repair of a mouse burn model, the recovery rate of the mouse skin is 2 days earlier than that of the ordinary umbilical cord extract. The umbilical cord extract prepared by the method provided by the present invention is expected to be widely used in wound or skin repair.
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