Coal worker pneumoconiosis animal model dust inhalation scientific research teaching experiment device

Abstract

The invention discloses a coal worker pneumoconiosis animal model dust inhalation scientific research teaching experiment device in the animal simulation experiment technical field, and the device comprises a box body and a life box, the life box is embedded in the upper part of the box body, the life box and the box body are connected through a weight scale, the life box comprises a life chamber and a dust raising chamber, and a separation plate is arranged between the life chamber and the dust raising chamber; a plurality of dust raising holes are formed in the partition plate, a living screen is laid at the bottom of the living chamber, wood chips are laid on the living screen, a first collecting opening is formed in the bottom wall of the living chamber below the living screen, and a dust raising assembly is fixedly connected to the interior of the dust raising chamber and used for simulating the biological activity dust raising condition; a quantitative supply assembly is fixedly connected to the upper part in the box body and is used for quantitatively spraying pulverized coal to the living box to simulate the working environment of coal workers. The device is novel and effective, flying dust caused by various factors is simulated in the flying dust chamber through the flying dust assembly, finally, the weight scale is used for weighing the weight change, the actual content of pulverized coal inhaled by mice is calculated, experimental errors are reduced, and the authenticity and reliability of experiments are improved.

Description

Technical Field

[0001] The invention belongs to the technical field of animal simulation experiments, in particular to a coal worker's pneumoconiosis animal model dust inhalation scientific research and teaching experimental device. Background Art

[0002] Coal workers' pneumoconiosis is an occupational lung disease caused by long-term inhalation of coal dust. During coal mining, workers are exposed to a large amount of coal dust, which deposits in the lungs and triggers a series of pathological changes, eventually leading to pulmonary fibrosis. In order to further study the pathogenesis of coal workers' pneumoconiosis, it is necessary to construct a corresponding animal model to simulate this process.

[0003] Constructing an animal model of coal workers' pneumoconiosis is an important part of scientific research and teaching experiments. Through animal models, we can simulate the working environment of coal miners, observe the impact of coal dust on the lungs, and then explore the pathogenic mechanism of coal workers' pneumoconiosis. Since coal dust from different sources in the working environment of coal miners may have different nature and degree of harm to the coal workers' lungs, and the protective measures for different sources are also different, such as coal dust from mining machines, coal dust caused by people walking or vehicle operation, etc. Based on this premise, animal models are also needed to evaluate the effectiveness of dust prevention measures and provide a scientific basis for occupational health protection of coal miners.

[0004] The existing animal model experiments of coal workers' pneumoconiosis are mainly conducted using rats, and the cultivation of rats is mainly carried out in living boxes, which are often arranged with dry sawdust, eating utensils and exercise equipment. Now, due to the lack of a relatively complete experimental living box, it is difficult to simulate the pathological effects of rats after natural inhalation of coal dust, not to mention the impact of floating particles of coal dust from various sources on the formation of coal workers' pneumoconiosis. In particular, there is a lack of experimental devices for quantitatively setting the concentration of inhaled coal dust. For example, announcement number CN111758585B makes it difficult to quantify the amount of coal dust inhaled by rats. For this reason, it is necessary to propose a coal worker pneumoconiosis animal model dust inhalation scientific research and teaching experimental device that can accurately control and calculate the amount of coal dust naturally inhaled by rats and can simulate the generation of floating particles of coal dust from various sources. Summary of the invention

[0005] In order to solve the above problems, the purpose of the present invention is to provide a coal worker's pneumoconiosis animal model dust inhalation scientific research and teaching experimental device, which inputs a certain amount of coal powder into the living box through a quantitative supply valve and an input pump, and simulates the dust caused by various factors in the dust chamber through a dust-raising component. Finally, a weight scale is used to weigh the weight change, and the actual coal powder content inhaled by the mouse is calculated, thereby reducing experimental errors and improving the authenticity and reliability of the experiment.

[0006] In order to achieve the above-mentioned purpose, the technical scheme of the present invention is as follows: a coal worker's pneumoconiosis animal model dust inhalation scientific research and teaching experimental device, comprising a box body and a living box, the living box is embedded in the upper part of the box body, the living box and the box body are connected by a weight scale, the living box comprises a living room and a dust chamber, a partition is provided between the living room and the dust chamber, a plurality of dust holes are provided on the partition, a living screen is laid at the bottom of the living room, sawdust is laid on the living screen, the output parts of a plurality of first electric push rods are fixedly connected to the edge of the bottom wall of the living screen, a first collecting port is provided on the bottom wall of the living room below the living screen, a plurality of first grooves for accommodating the first electric push rods are provided on the outer periphery of the first collecting port, a horizontal collecting channel is provided below the first collecting port, a collecting shovel is provided in the collecting channel, a second collecting port is connected to the side of the collecting channel close to the dust chamber, the second collecting port is connected to the bottom wall of the dust chamber, a second electric push rod vertically upward is embedded in the middle of the second collecting port, and the output part of the second electric push rod is hinged to a dust bottom plate, the dust bottom plate is located on the bottom wall of the dust chamber and is hinged to one side of the bottom of the dust chamber;

[0007] A dust collection component is fixedly connected inside the dust collection chamber to simulate the dust collection situation of biological activities; a quantitative supply component is fixedly connected to the upper part of the box body to spray coal powder into the living box in a quantitative manner to simulate the working environment of coal workers.

[0008] The principle of the basic solution is: a quantitative supply component is used to input a certain amount of coal powder into the mice in the living box every day to simulate the mine environment. After the coal powder has settled for a period of time, the coal powder settled in the dust chamber is raised again through the dust collection component to simulate the dust situation in the mine.

[0009] The beneficial effects of the basic scheme are: 1. Through the precise quantitative supply of components, the coal powder concentration in the actual working environment of coal workers can be simulated to ensure the consistency of experimental conditions, thereby improving the accuracy and repeatability of the experiment.

[0010] 2. Through the built-in dust-raising component, the flying of coal dust caused by biological activities (such as mouse activities) can be simulated, making the experimental environment closer to the real workplace, which is helpful for studying the pathogenesis of coal workers' pneumoconiosis.

[0011] 3. The living box is connected to the box body by a weight scale, which can accurately measure the weight change of the living box during the experiment, thereby calculating the actual amount of coal powder inhaled by the mice and reducing experimental errors.

[0012] 4. The first electric push rod pushes the living screen to move, which is convenient for cleaning and collecting wood chips on the living screen; the second electric push rod puts the coal powder in the dust chamber into the second collection port through the hinged dust bottom plate, and finally collects and processes it through the collection shovel and collection channel. This design not only improves the convenience of the experiment, but also helps to reduce coal powder pollution during the experiment.

[0013] Furthermore, the dust removal component includes a support column fixed between the partition and the side wall of the dust removal chamber, a support ring is fixedly connected to the center of the support column, a gear slip ring is slidably sleeved in the support ring, a third electric push rod is fixedly connected to the inner wall of the gear slip ring, and the output part of the third electric push rod is vertically fixedly connected to the dust removal plate downward, rotating teeth are opened on the outer periphery of the bottom of the gear slip ring, motor gears are meshed on both sides of the rotating teeth, the motor gears are coaxially fixedly connected to the output shaft of the rotating motor, the rotating motors are respectively fixedly connected to the support columns on both sides of the gear slip ring, the rotating motor and the gear slip ring are covered with protective shells, and the protective shells are fixedly connected to the support columns.

[0014] The beneficial effects of the basic scheme are: 1. Through the synergistic effect of the third electric push rod and the rotating motor, the dust plate can move up and down and rotate, simulating the flying of coal powder caused by biological activities, making the experimental environment closer to the real workplace.

[0015] 2. By adjusting the parameters of the third electric push rod and the rotating motor, the movement and rotation speed of the dust plate can be accurately controlled, thereby adjusting the degree and range of coal powder flying, making the experimental environment more controllable.

[0016] 3. The design of the protective shell effectively prevents impurities such as coal powder from entering the motor, avoids performance degradation or damage to the motor due to accumulation of impurities, and extends the service life of the motor.

[0017] Furthermore, the quantitative supply component includes a supply funnel connected to the top wall of the box body, a refined screen is fixedly connected to the middle of the supply funnel, coal powder is filled below the refined screen, the bottom of the supply funnel is connected to a quantitative supply valve, the output end of the quantitative supply valve is connected to an input pump, the end of the input pump away from the quantitative supply valve is connected to an input pipe, the input pipe passes through the box body into the living box and is located in the upper part of the living box and is connected to an upward diffuser, and a turbine fan is fixedly connected in the diffuser.

[0018] The beneficial effects of the basic scheme are: 1. Through the precise control of the quantitative supply valve, the supply amount of coal powder in each experiment can be ensured to be consistent, thereby eliminating the experimental error caused by different amounts of coal powder and improving the accuracy and reliability of the experiment.

[0019] 2. The use of refined screens makes the coal powder particles more uniform, which helps to simulate the coal powder concentration in a real working environment. At the same time, the turbine fan in the diffuser can evenly diffuse the coal powder into the living box through the turbulence effect, ensuring the consistency of the experimental environment and further improving the accuracy of the experiment.

[0020] Furthermore, the quantitative supply valve includes a supply motor, which is fixedly connected to the inner wall of the box body. The output shaft of the supply motor is fixedly connected to a star-shaped valve located at the bottom of the supply funnel. The star-shaped valve cooperates with the pipe wall at the bottom of the supply funnel to control the quality of the supplied coal powder.

[0021] The beneficial effects of the basic scheme are: 1. By adjusting the speed and rotation time of the motor, the opening degree and duration of the star valve can be finely controlled, thereby achieving precise control of the coal powder supply. This design not only improves the accuracy of the experiment, but also ensures the consistency of coal powder supply in each experiment, providing reliable data support for scientific research.

[0022] 2. Traditional coal powder supply methods often have problems such as uneven supply and difficulty in precise control, while the quantitative supply valve effectively solves these problems. Through precise motor control and valve design, it can ensure that the coal powder enters the experimental device at a stable speed and flow rate, thereby improving the efficiency of the experiment.

[0023] 3. The automated design of the quantitative supply valve greatly simplifies the experimental operation process. Researchers can achieve accurate supply of pulverized coal by simply setting the parameters of the motor without the need for tedious manual operations. This design not only reduces experimental errors caused by human factors, but also improves the repeatability and comparability of the experiment.

[0024] Furthermore, the walls of the living box are made of transparent material.

[0025] The beneficial effects of the basic scheme are: 1. The transparent material allows the experimenter to directly observe the activity status, behavioral response and distribution of coal powder of the mice in the living box. Without opening the living room, the experiment progress can be obtained in real time, avoiding the interference factors that may be introduced by opening the living box.

[0026] 2. Through direct observation, the experimenters can more accurately judge the health status of mice, behavioral changes and the impact of coal powder on mice, thereby reducing experimental errors caused by subjective judgment or misoperation. The transparent living box provides more direct and reliable experimental observation data, which helps the experimenters to draw more accurate conclusions.

[0027] 3. The living box wall made of transparent material can effectively isolate the experimental environment from the outside world, preventing mice from escaping or external interference factors from affecting the experiment. It avoids the introduction of microorganisms, dust and other pollutants that may be introduced due to frequent opening of the living box, ensuring the cleanliness and stability of the experimental environment.

[0028] 4. The transparent living box makes the experimental process more intuitive and vivid, which helps to attract students' attention and improve teaching effectiveness. During the experiment, teachers and students can observe and discuss experimental phenomena and results together, promoting academic exchanges and cooperation.

[0029] Furthermore, an elastic opening is fixedly connected at the connection point between the living box and the input pipe, and the elastic opening is slidably connected to the input pipe.

[0030] The beneficial effects of the basic scheme are: 1. The elastic port has good elasticity and flexibility, and can fit closely to the surface of the input pipe to form an effective seal. This sealing performance can prevent coal powder from leaking from the dust chamber during transportation, ensuring that the coal powder can enter the living box accurately and completely, thereby improving the accuracy and reliability of the experiment.

[0031] 2. During the operation of the experimental device, the input pipe may produce a slight displacement due to factors such as coal powder input and pipeline vibration. Traditional rigid connections are difficult to adapt to this displacement, while the elastic port can solve this problem well. Through its own elasticity and flexibility, it can absorb and compensate for the displacement of the input pipe and ensure the stability and sealing of the connection.

[0032] Furthermore, a spring is fixedly connected between the top of the partition and the input pipe, and the partition is made of an opaque material.

[0033] The beneficial effects of the basic scheme are: 1. The partition made of opaque material can effectively block the interference to the normal life of mice caused by the movement of the third electric push rod, which is crucial for scientific research and teaching experiments that require precise control of experimental conditions.

[0034] 2. As an elastic element, the spring can provide a buffering effect when the input pipe injects coal powder into the living chamber. It can also make the movement of the input pipe relative to the living box smoother, reduce the possibility of collision, and make the experimental device more stable during operation.

[0035] Further, the aperture of the living screen is smaller than the diameter of the sawdust.

[0036] The beneficial effects of the basic scheme are: 1. Since the aperture of the screen is smaller than the sawdust, it can effectively prevent large particles of impurities such as sawdust from entering the first collection port, affecting the subsequent collection of coal powder, and improving the accuracy of subsequent processing or analysis.

[0037] 2. The aperture of the living screen is smaller than the sawdust. When the first electric push rod lifts the living screen, more coal powder can be shaken into the first collecting port without worrying about sawdust falling in, which is convenient for the experimenters to clean the living room and weigh the remaining coal powder.

[0038] Furthermore, a living cover is provided on the top wall of the living chamber, a supply cover is provided on the top wall of the supply funnel, and sealing strips are affixed to the outer peripheries of the living cover and the supply cover.

[0039] The beneficial effects of the basic scheme are: 1. The setting of the sealing strip significantly enhances the sealing performance between the living cover and the supply cover and their respective top walls. This design can effectively prevent external air, moisture, dust and other impurities from entering the living room or the supply funnel, thereby keeping the internal environment clean and stable.

[0040] 2. The improvement of sealing performance not only helps to maintain the stability of the internal environment, but also enhances safety to a certain extent, preventing coal dust and mice in the living room from being affected by the outside world.

[0041] Furthermore, a water dispenser, a feeder, a teething stick and an exercise wheel are provided in the corners of the living room.

[0042] The beneficial effects of the basic scheme are: 1. These instruments distributed in the corners of the living box can fully mobilize the frequency of rats stepping and moving on the sawdust in the coal powder inhalation experiment. These movements can promote the residual coal powder in the sawdust to fall into the powder screen and be recovered, reduce the interference of residual coal powder on the next coal powder input concentration, and ensure the reliability of the coal powder inhalation experiment.

[0043] 2. The design of automatic water and food supply reduces the operation frequency of experimenters, reduces the impact of human factors on experimental results, and improves the accuracy of the experiment.

[0044] 3. When rats exercise and grind their teeth, their heart rate increases and their breathing process is significantly enhanced, which is beneficial for coal powder inhalation experiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] Figure 1 It is an axonometric diagram of the coal worker pneumoconiosis animal model dust inhalation scientific research and teaching experimental device in an embodiment of the present invention.

[0046] Figure 2 It is a front cross-sectional view of the coal worker pneumoconiosis animal model dust inhalation scientific research and teaching experimental device in an embodiment of the present invention.

[0047] Figure 3 It is a side view of the coal worker pneumoconiosis animal model dust inhalation scientific research and teaching experimental device in an embodiment of the present invention.

[0048] The figure marks in the drawings of the specification include: 1. box body; 2. weight scale; 3. input pump; 4. supply motor; 5. star valve; 6. coal powder; 7. fine screen; 8. supply cover; 9. input pipe; 10. elastic port; 11. gear slip ring; 12. third electric push rod; 13. dust plate; 14. rotating motor; 15. support column; 16. spring; 17. partition; 18. dust hole; 19. diffusion port; 20. turbo fan; 21. living cover; 22. living box; 23. feeder; 24. teething stick; 25. wood chips; 26. first collecting port; 27. first electric push rod; 28. collecting shovel; 29. ​​collecting channel; 30. second collecting port; 31. dust bottom plate; 32. second electric push rod. DETAILED DESCRIPTION

[0049] The following is further described in detail through specific implementation methods:

[0050] Example

[0051] Basically as attached Figure 1 , Figure 2 and Figure 3 As shown: a coal worker's pneumoconiosis animal model dust inhalation scientific research and teaching experimental device, including a box body 1 and a living box 22, the living box 22 is embedded in the upper part of the box body 1, the walls of the living box 22 are made of transparent material, the living box 22 and the box body 1 are connected by a weight scale 2, the living box 22 includes a living room and a dust room, the living room and the dust room are separated by a partition 17, the living room corners are respectively provided with a water dispenser, a feeder 23, a molar rod 24 and a sports wheel, the partition 17 is opened with a plurality of dust holes 18, the bottom of the living room is paved with a living screen, the living screen is paved with wood chips 25, the aperture of the living screen is smaller than the diameter of the wood chips 25, and the bottom wall edge of the living screen is fixedly connected There are several output parts of the first electric push rods 27, and the bottom wall of the living chamber below the living screen is provided with a first collecting port 26. The outer periphery of the first collecting port 26 is provided with several first grooves for accommodating the first electric push rods 27, and a transverse collecting channel 29 is provided below the first collecting port 26. A collecting shovel 28 is provided in the collecting channel 29. The side of the collecting channel 29 close to the dust chamber is connected with a second collecting port 30, and the second collecting port 30 is connected to the bottom wall of the dust chamber. A second electric push rod 32 pointing vertically upward is embedded in the middle of the second collecting port 30, and the output part of the second electric push rod 32 is hinged with a dust bottom plate 31, and the dust bottom plate 31 is located on the bottom wall of the dust chamber and is hinged to one side of the bottom of the dust chamber.

[0052] A dust collecting component is fixedly connected inside the dust collecting chamber to simulate the dust collecting situation of biological activities. The dust collecting component includes a support column 15 fixed between a partition 17 and a side wall of the dust collecting chamber. A support ring is fixedly connected to the center of the support column 15. A gear slip ring 11 is slidably sleeved inside the support ring. A third electric push rod 12 is fixedly connected to the inner wall of the gear slip ring 11. A dust collecting plate 13 is fixedly connected to the output portion of the third electric push rod 12 vertically downward. Rotating teeth are provided on the outer periphery of the bottom of the gear slip ring 11. Motor gears are meshed on both sides of the rotating teeth. The motor gears are coaxially fixedly connected to the output shaft of the rotating motor 14. The rotating motor 14 is fixedly connected to the support columns 15 on both sides of the gear slip ring 11. The rotating motor 14 and the gear slip ring 11 are covered with protective shells, and the protective shell is fixedly connected to the support column 15.

[0053] A quantitative supply component is fixedly connected to the upper part of the box body 1, which is used to quantitatively spray coal powder 6 into the living box 22 to simulate the working environment of coal workers. The quantitative supply component includes a supply funnel connected to the top wall of the box body 1, a fine screen 7 is fixedly connected to the middle of the supply funnel, and coal powder 6 is filled below the fine screen 7. The bottom of the supply funnel is connected to a quantitative supply valve, which includes a supply motor 4, which is fixedly connected to the inner wall of the box body 1, and the output shaft of the supply motor 4 is fixedly connected to a star valve 5 located at the bottom of the supply funnel, and the star valve 5 is connected to the pipe wall at the bottom of the supply funnel. In order to control the quality of the supplied coal powder 6, the output end of the quantitative supply valve is connected to the input pump 3, and the end of the input pump 3 away from the quantitative supply valve is connected to the input pipe 9. The connection between the living box 22 and the input pipe 9 is fixedly connected with an elastic port 10, and the elastic port 10 is slidably connected to the input pipe 9. A spring 16 is fixedly connected between the top of the partition 17 and the input pipe 9. The partition 17 is made of an opaque material. The input pipe 9 passes through the box body 1 and enters the living box 22 and is located in the upper part of the living box 22 and is connected to an upward diffuser 19, and a turbofan 20 is fixedly connected in the diffuser 19.

[0054] A living cover 21 is provided on the top wall of the living chamber, and a supply cover 8 is provided on the top wall of the supply hopper. Sealing strips are affixed to the outer peripheries of the living cover 21 and the supply cover 8.

[0055] The specific implementation process is as follows: before conducting the experiment, the overall weight of the living box 22 is weighed and recorded using the weight scale 2, and then the living cover 21 and the supply cover 8 are opened to first spread sawdust 25 on the living sieve plate of the living room, add a certain amount of raw materials to the waterer and feeder 23, and add a certain amount of coal powder 6 of the required diameter into the supply funnel through the refined screen 7, and then put a number of rats into the living room. The coal powder 6 inhalation experiment can be carried out after a week of adaptive training, which is beneficial to reduce the experimental errors caused by stress.

[0056] Before conducting the coal powder 6 inhalation experiment, the supply amount of the quantitative supply valve is set. Under the condition of simulating the daily working hours of a coal miner, the supply motor 4, which serves as a servo motor, drives the star valve to rotate and let a quantitative amount of coal powder 6 fall into the front end of the input pump 3. The input pump 3 transports the coal powder 6 and blows it into the input pipe 9 into the living box 22. Since the end of the input pipe 9 is connected to the diffuser 19, and the diffuser 19 has a turbofan 20 with a turbulent effect, the input pipe 9 is a hard pipe that is sufficient to support the weight of the diffuser 19 and the turbofan 20. The airflow carrying coal powder 6 is disrupted and hits the top wall of the living box 22 and is fully and evenly mixed into the air of the living box 22, simulating the situation where coal powder 6 is diffused during coal mining.

[0057] After a period of time, the coal dust 6 originally diffused in the living box 22 gradually settles on the surface of the sawdust 25 in the living room and the dust bottom plate 31 in the dust room. At this time, the third electric push rod 12 and the rotary motor 14 can be turned on. The third electric push rod 12 pushes the dust plate 13 to continuously move downward and reciprocate to hit the dust bottom plate 31. The rotary motor 14 rotates the dust plate 13 and provides dust removal efficiency, simulating the coal dust 6 dust caused by the movement of people and vehicles in the workplace of coal miners, and providing a new simulation research direction for the dust inhalation experiment of coal miners' pneumoconiosis animal model. The raised coal dust 6 enters the living room through the dust hole 18 on the partition 17, and the activities of rats in the living room can also cause the coal dust 6 settled on the sawdust 25 to be dusted again.

[0058] After continuous input of coal powder 6 and re-dust environment simulation, after the preset number of simulation days, the experimenter turned off the supply motor 4, opened the living cover 21, carefully cleaned the coal powder 6 on the surface of the mouse and put it into the living box 22, took the mouse to detect the pulmonary fibrosis index in the body, turned on the first electric push rod 27 and the second electric push rod 32, the first electric push rod 27 lifted the sawdust 25 on the living screen, so that the experimenter can better clean the coal powder 6 remaining in the sawdust 25 and make it fall into the first collecting port 26, then take out the cleaned sawdust 25 and other debris, the coal powder 6 enters the collecting shovel 28 through the first collecting port 26, the second electric push rod 32 pulls the dust bottom plate 31 down and tilts it to dock with the second collecting port 30, so that the dust bottom plate The coal powder 6 remaining on 31 also enters the second collection port 30. The experimenter can clean the coal powder 6 in the dust chamber and enter the second collection port 30, such as the coal powder 6 on the protective shell and the support column 15. The coal powder 6 entering the second collection port 30 also slides into the collection shovel 28. At this time, the weight scale 2 is used to weigh the overall weight of the living box 22 after the experiment again. In the process of weighing the living box 22, there will be a relative displacement between the living box 22 and the input pipe 9 entering the living box 22, thereby causing mutual collision between the input pipe 9 and the wall of the living box 22. The elastic port 10 ring-connected to the outside of the input pipe 9 can effectively avoid such collision, and the input pipe 9 is also connected to the top of the partition 17 with a spring 16, which can effectively alleviate the impact force. The opaque partition 17 can prevent the moving dust plate 13 from affecting the mouse vision and causing experimental errors.

[0059] By subtracting the overall weight of the living box 22 before the experiment from the overall weight of the living box 22 after the experiment, a clear weight of the coal powder 6 inhaled by the rat during the experiment can be obtained, which is convenient and fast and conducive to the efficient conduct of the experiment.

[0060] Use this device to conduct coal powder inhalation experiment:

[0061] 1. Animals: 150 male Wistar rats, weighing 180-200 g.

[0062] 2. Preparation of coal dust particles: Take first-grade anthracite, grind it, filter it through a 200-mesh steel mesh, sterilize it under high pressure, and dry it for later use.

[0063] 3. Experimental grouping and treatment: After one week of adaptive feeding, the rats were randomly divided into a control group (30 rats), a coal powder inhalation group (40 rats) and a dust group (80 rats). The control group was fed with an equal amount of air and low-speed dust. The coal powder inhalation group 1 was set such that the peak coal powder concentration in the living box reached 30g / L after the coal powder was fed, the dust frequency was 2 times / s, and the dust time was 4 hours a day. The coal powder inhalation group 2 was set such that the peak coal powder concentration in the living box reached 70g / L after the coal powder was fed, and the dust conditions were the same as above. The dust group 1.1 was set such that the peak coal powder concentration in the living box reached 30g / L after the coal powder was fed, the dust frequency was 4 times / s, and the dust time was 4 hours a day. The dust group 1.2 was set such that the peak coal powder concentration in the living box reached 30g / L after the coal powder was fed, the dust frequency was 6 times / s, and the dust time was 4 hours a day. The dust groups 2.1 and 2.2 were set such that the peak coal powder concentration in the living box reached 70g / L after the coal powder was fed, and the dust conditions were the same as above. All experimental animals were raised under the same conditions and had free access to food.

[0064] One week later, 10 rats were randomly selected from the control group, coal dust inhalation group 1, coal dust inhalation group 2, dust group 1.1, dust group 1.2, dust group 2.1 and dust group 2.2 to detect changes in blood gas and lung tissue fibrosis index.

[0065] 4. Statistical methods: All parameters were expressed as mean ± standard deviation (x ± s). All data were analyzed by one-way analysis of variance, LSD-t test between groups, and factorial analysis of variance using SPSS 18.0. P < 0.05 was considered statistically significant.

[0066] The results are shown in Table 1:

[0067] Table 1 Changes of blood gas and lung tissue fibrosis index in rats with coal dust inhalation

[0068]

[0069] Compared with the control group, * P<0.05; compared with the 8-week experimental group, # P<0.05; 1mmHg=0.133kPa.

[0070] As the inhalation concentration of coal powder inhaled animals increased, the arterial oxygen partial pressure (PaO2) gradually decreased and the arterial carbon dioxide partial pressure (PaCO2) gradually increased, indicating that the lung function of the experimental group animals gradually decreased after dust exposure and was related to the dust concentration; the lung tissue fibrosis index showed a significant increase with the progression of the disease, indicating that dust exposure is an important factor causing lung tissue fibrosis, and among various dust exposure factors, the impact of changes in the total amount of input coal powder was significantly greater than that of physical dust on mouse lung tissue fibrosis, proving that in the actual working environment of miners, special attention should be paid to controlling the coal powder content in the air to reduce the probability of coal workers' pneumoconiosis.

[0071] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0072] The above is only an embodiment of the present invention. The common sense such as the known specific structure and characteristics in the scheme is not described in detail here. The ordinary technicians in the relevant field know all the common technical knowledge in the technical field of the invention before the application date or priority date, can obtain all the existing technologies in the field, and have the ability to apply the conventional experimental means before that date. The ordinary technicians in the relevant field can improve and implement this scheme in combination with their own abilities under the enlightenment given by this application. Some typical known structures or known methods should not become obstacles for ordinary technicians in the relevant field to implement this application. It should be pointed out that for those skilled in the art, without departing from the structure of the present invention, several deformations and improvements can be made, which should also be regarded as the protection scope of the present invention, which will not affect the effect of the implementation of the present invention and the practicality of the patent. The protection scope required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A coal worker pneumoconiosis animal model dust inhalation scientific research and teaching experimental device, comprising a box (1) and a living box (22), wherein the living box (22) is embedded in the upper part of the box (1), and is characterized in that: The living box (22) is connected to the box body (1) via a weight scale (2). The living box (22) comprises a living room and a dust-raising room. A partition (17) is provided between the living room and the dust-raising room. A plurality of dust-raising holes (18) are provided on the partition (17). A living screen is provided at the bottom of the living room. The living screen is provided with wood chips (25). The output parts of a plurality of first electric push rods (27) are fixedly connected to the edge of the bottom wall of the living screen. A first collecting port (26) is provided on the bottom wall of the living room below the living screen. The outer periphery of the first collecting port (26) is provided with a port for accommodating the first electric push rods (27). A plurality of first grooves of the push rod (27), a transverse collecting channel (29) is opened below the first collecting port (26), a collecting shovel (28) is arranged in the collecting channel (29), a side of the collecting channel (29) close to the dust chamber is connected to a second collecting port (30), the second collecting port (30) is connected to the bottom wall of the dust chamber, a second electric push rod (32) is vertically upwardly embedded in the middle of the second collecting port (30), the output part of the second electric push rod (32) is hinged to a dust bottom plate (31), the dust bottom plate (31) is located on the bottom wall of the dust chamber and is hinged to one side of the bottom of the dust chamber; A dust raising component is fixedly connected inside the dust raising chamber for simulating dust raising caused by biological activities; a quantitative supply component is fixedly connected to the upper part of the box body (1) for quantitatively spraying coal powder (6) into the living box (22) to simulate the working environment of coal miners.

2. The coal worker pneumoconiosis animal model dust inhalation scientific research and teaching experimental device according to claim 1, characterized in that: The dust removal component comprises a support column (15) fixed between a partition (17) and a side wall of the dust removal chamber, a support ring fixedly connected to the center of the support column (15), a gear slip ring (11) slidably sleeved inside the support ring, a third electric push rod (12) fixedly connected to the inner wall of the gear slip ring (11), an output portion of the third electric push rod (12) vertically downwardly fixedly connected to a dust removal plate (13), a rotating tooth is provided on the outer periphery of the bottom of the gear slip ring (11), motor gears are meshed on both sides of the rotating tooth, the motor gears are coaxially fixedly connected to the output shaft of the rotating motor (14), the rotating motor (14) is fixedly connected to the support columns (15) on both sides of the gear slip ring (11), the rotating motor (14) and the gear slip ring (11) are respectively covered with a protective shell, and the protective shell is fixedly connected to the support column (15).

3. The coal worker pneumoconiosis animal model dust inhalation scientific research and teaching experimental device according to claim 2, characterized in that: The quantitative supply component comprises a supply funnel connected to the top wall of a box body (1), a fine screen (7) is fixedly connected to the middle of the supply funnel, coal powder (6) is filled below the fine screen (7), a quantitative supply valve is connected to the bottom end of the supply funnel, an input pump (3) is connected to the output end of the quantitative supply valve, an input pipe (9) is connected to the end of the input pump (3) away from the quantitative supply valve, the input pipe (9) passes through the box body (1) and enters the living box (22) and is connected to an upward diffuser (19) at the upper part of the living box (22), and a turbine fan (20) is fixedly connected to the diffuser (19).

4. The coal worker pneumoconiosis animal model dust inhalation scientific research and teaching experimental device according to claim 3, characterized in that: The quantitative supply valve comprises a supply motor (4), the supply motor (4) is fixedly connected to the inner wall of the box body (1), the output shaft of the supply motor (4) is fixedly connected to a star-shaped valve (5) located at the bottom end of the supply funnel, and the star-shaped valve (5) cooperates with the pipe wall at the bottom end of the supply funnel to control the quality of the supplied coal powder (6).

5. The coal worker pneumoconiosis animal model dust inhalation scientific research and teaching experimental device according to claim 1, characterized in that: The walls of the living box (22) are all made of transparent material.

6. The coal worker pneumoconiosis animal model dust inhalation scientific research and teaching experimental device according to claim 1, characterized in that: An elastic opening (10) is fixedly connected to the connection between the living box (22) and the input pipe (9), and the elastic opening (10) is slidably connected to the input pipe (9).

7. The coal worker pneumoconiosis animal model dust inhalation scientific research and teaching experimental device according to claim 1, characterized in that: A spring (16) is fixedly connected between the top of the partition (17) and the input pipe (9), and the partition (17) is made of an opaque material.

8. The coal worker pneumoconiosis animal model dust inhalation scientific research and teaching experimental device according to claim 1, characterized in that: The aperture of the living screen is smaller than the diameter of the wood chips (25).

9. The coal worker pneumoconiosis animal model dust inhalation scientific research and teaching experimental device according to claim 4, characterized in that: The top wall of the living room is provided with a living cover (21), the top wall of the supply funnel is provided with a supply cover (8), and the outer peripheries of the living cover (21) and the supply cover (8) are both affixed with sealing strips.

10. The coal worker pneumoconiosis animal model dust inhalation scientific research and teaching experimental device according to claim 1, characterized in that: A drinking fountain, a feeding device (23), a teeth grinding rod (24) and a sports wheel are respectively arranged at the corners of the living room.

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