Oral composition, and method for suppressing bitterness derived from ergothioneine or salt thereof and odor derived from raw material containing ceramide derived from milk

Abstract

The purpose of the present invention is to provide: an oral composition which contains ergothioneine or a salt thereof and a raw material containing a ceramide derived from milk, and which can inhibit bitterness from ergothioneine or a salt thereof and odor from a raw material containing a ceramide derived from milk; and a method for suppressing bitterness from ergothioneine or a salt thereof and odor from a raw material containing a ceramide derived from milk. However, bitterness from ergothioneine or a salt thereof and odor from a ceramide-containing raw material derived from milk are suppressed. The present invention pertains to an oral composition characterized by containing the following components (A) and (B): (A) ergothioneine or a salt thereof, and (B) a raw material containing a ceramide derived from milk, the weight ratio of component (B) to component (A) (in terms of ergothioneine), i.e., (B) / (A), being 2-70.

Description

Technical Field

[0001] The present invention relates to an oral composition and a method for suppressing bitterness derived from ergothioneine or its salt and odor derived from a milk-derived ceramide-containing raw material. Background Art

[0002] Ergothioneine is one of hydrophilic sulfur-containing amino acids, and it is known that it has a variety of physiological activities headed by antioxidant capacity. Regarding the physiological activity of ergothioneine, for example, in patent documentation 1, it is reported that immune response activation cytokines produce promotion effects, etc. Because ergothioneine has a variety of physiological activities, it has attracted much attention in recent years as food, cosmetics or medicine.

[0003] Sphingomyelin contained in milk is a precursor of ceramide and is a type of sphingolipid having a sphingosine base. The raw material containing sphingomyelin derived from cow's milk is called milk ceramide.

[0004] Patent Literature Patent Document 1: Japanese Patent Application Publication No. 2017-218431 Summary of the invention

[0005] As mentioned above, because thioneine possesses useful physiological activity, the food such as the supplement containing thioneine or its salt is useful for maintaining or promoting health. In addition, the raw material containing ceramide in milk source presents the moisturizing effect to skin. Therefore it is generally believed that by taking in the oral composition of the raw material containing ceramide in thioneine or its salt and milk source, various useful effects can be expected. However, thioneine or its salt has unique fragrance, especially has bitter taste like pricking tongue, and still has room for improvement in making oral composition. In addition, the raw material containing ceramide in milk source has its unique stink (the general fishy smell of milk), which sometimes becomes a problem when being deployed in oral composition.

[0006] The object of the present invention is to provide an oral composition, which contains ergothioneine or its salt and a milk-derived ceramide-containing raw material, but the bitter taste from ergothioneine or its salt and the odor from the milk-derived ceramide-containing raw material are suppressed. In addition, the object of the present invention is to provide a method for suppressing the bitter taste from ergothioneine or its salt and the odor from the milk-derived ceramide-containing raw material.

[0007] The present inventors have conducted intensive studies to solve the above problems and have found that the bitter taste derived from ergothioneine or its salt and the odor derived from the milk-derived ceramide-containing raw material can be suppressed by combining ergothioneine or its salt and the milk-derived ceramide-containing raw material at a specific ratio.

[0008] The present invention includes the following oral compositions and methods for suppressing bitterness derived from ergothioneine or a salt thereof and odor derived from a milk-derived ceramide-containing raw material, but is not limited thereto. [1] An oral composition comprising the following ingredients (A) and (B): (A) ergothioneine or a salt thereof, and (B) a milk-derived ceramide-containing raw material, The weight ratio of the component (B) to the component (A) (calculated as ergothioneine), that is, (B) / (A) is 2 to 70. [2] The composition according to [1] above, wherein the weight ratio of component (B) to component (A) (calculated as ergothioneine), i.e. (B) / (A), is 3 to 60. [3] The composition according to [1] or [2] above, wherein (B) the milk-derived ceramide-containing raw material is ceramide-containing whey powder. [4] The composition according to any one of [1] to [3] above, characterized in that the (B) milk-derived ceramide-containing raw material contains (C) sphingomyelin, and the weight ratio of (C) sphingomyelin to component (A) (calculated as ergothioneine), i.e. (C) / (A), is 0.01 to 10. [5] The composition according to any one of [1] to [4] above, wherein the milk is cow's milk. [6] The composition according to any one of [1] to [5] above, which is a food or beverage. [7] A method for suppressing the bitter taste derived from ergothioneine or its salt and the odor derived from a milk-derived ceramide-containing raw material, characterized in that, in an oral composition containing the following components (A) and (B): (A) ergothioneine or a salt thereof, and (B) a milk-derived ceramide-containing raw material, The weight ratio of the component (B) to the component (A) (calculated as ergothioneine), that is, (B) / (A) is adjusted to 2 to 70.

[0009] According to the present invention, an oral composition can be provided, which contains ergothioneine or its salt and a milk-derived raw material containing ceramide, but the bitter taste from ergothioneine or its salt and the odor from the milk-derived raw material containing ceramide are suppressed. In addition, according to the present invention, a method for suppressing the bitter taste from ergothioneine or its salt and the odor from the milk-derived raw material containing ceramide can be provided. DETAILED DESCRIPTION

[0010] The oral composition of the present invention contains (A) ergothioneine or a salt thereof (component (A)) and (B) a milk-derived ceramide-containing raw material (component (B)), wherein the weight ratio ((B) / (A)) of component (B) to component (A) (calculated as ergothioneine) is 2 to 70.

[0011] Ergothioneine is a kind of sulfur-containing amino acid. In the present invention, ergothioneine is preferably L-ergothioneine. As the salt of ergothioneine, as long as it is a pharmacologically acceptable salt or a salt allowed in a diet, there is no particular limitation, and it may be any of an acidic salt and an alkaline salt. As an acidic salt, for example, inorganic acid salts such as hydrochloride, sulfate, nitrate, and phosphate can be listed; organic acid salts such as acetate, citrate, maleate, malate, oxalate, lactate, succinate, fumarate, and propionate can be listed. As an alkaline salt, for example, alkali metal salts such as sodium salt and potassium salt can be listed; alkaline earth metal salts such as calcium salt and magnesium salt can be listed.

[0012] Ergothioneine or its salt is not subject to any restrictions such as its form or manufacturing method. Ergothioneine or its salt can be a chemically synthesized product, or it can be a substance extracted or purified from a natural product. L-ergothioneine is contained in a large amount in the golden top pleurotus (Golden / Yellow Oyster Mushroom) (scientific name: Pleurotuscornucopiae var.citrinopileatus) of the mushroom belonging to the genus Pleurotus of the family Pleurotus. L-ergothioneine is also contained in mushrooms such as Agaricus bisporus (scientific name: Agaricus bisporus), Grey Oyster Mushroom (scientific name: Pleurotus ostreatus), Lentinula edodes (scientific name: Lentinula edodes), Grifola frondosa (scientific name: Grifola frondosa), Ganoderma lucidum (scientific name: Ganoderma lucidum), Hericium erinaceus (scientific name: Hericiumerinaceus), Agrocybe aegerita (scientific name: Agrocybe aegerita), Chanterelles (scientific name: Cantharelus cibarius), Boletus (scientific name: Boletus edulis), Morchella esculenta (scientific name: Morchella esculenta), etc. When L-ergothioneine is obtained from natural products, it is preferably extracted from Pleurotus eryngii. Ergothioneine or its salt can also be produced by microbial fermentation. Ergothioneine or its salt may be an isolated substance.

[0013] In the present invention, the so-called milk-derived ceramide-containing raw material refers to a raw material from milk containing (C) sphingomyelin. As milk, cow's milk is preferred. In the present invention, the milk-derived ceramide-containing raw material is preferably a ceramide-containing raw material from cow's milk. The ceramide-containing raw material from cow's milk is called milk ceramide. The milk-derived ceramide-containing raw material can be a mixture of milk phospholipids (lipids), carbohydrates, and proteins.

[0014] The oral composition of the present invention may contain commercially available lactoceramide as a milk-derived ceramide-containing raw material. Examples of the milk-derived ceramide-containing raw material include those prepared using a known method.

[0015] The content of sphingomyelin in the milk-derived ceramide-containing raw material is preferably 0.5% by weight or more, more preferably 1 to 30% by weight, further preferably 1 to 10% by weight, particularly preferably 1 to 5% by weight.

[0016] As the raw material containing ceramide from milk (B), whey powder containing ceramide is preferred. As whey powder containing ceramide, commercially available substances (e.g., trade name Milk Ceramide MC-5, manufactured by Snow Brand Dairy Co., Ltd., Milk Ceramide PLC, Tatua Co-operative Dairy Co., Ltd.) can be used. Whey powder containing ceramide can also be prepared by the method described in Japanese Patent Publication No. 2007-89535, for example.

[0017] In the oral composition of the present invention, the weight ratio ((B) / (A)) of (B) the milk-derived ceramide-containing raw material (component (B)) to (A) ergothioneine or its salt (component (A)) in terms of ergothioneine is 2 to 70. Ergothioneine or its salt has bitter taste like pricking the tongue. In addition, the raw material containing ceramide in milk source has its unique milk-like fishy smell. In the composition containing components (A) and (B), if the weight ratio ((B) / (A)) of component (B) relative to component (A) (ergothioneine conversion) is above-mentioned range, the bitter taste from component (A) can be suppressed, and the stench from component (B) can also be effectively suppressed simultaneously. Therefore, the continuous intake of the raw material containing ceramide in milk source can be made easy. The weight ratio ((B) / (A)) is preferably 3 or more, more preferably 4 or more, and further preferably 5 or more. In addition, it is preferably 60 or less, more preferably 55 or less, and further preferably 50 or less. In one embodiment, the weight ratio ((B) / (A)) of component (B) relative to component (A) (calculated as ergothioneine) is preferably 3 to 60, more preferably 4 to 55, and further preferably 5 to 50. The amount of ergothioneine or its salt converted to ergothioneine or an expression similar thereto, in the case of ergothioneine, refers to the amount thereof. In the case of a salt of ergothioneine, it refers to the value obtained by multiplying the number of moles of the salt by the molecular weight of ergothioneine.

[0018] In the oral composition of the present invention, the weight ratio ((C) / (A)) of (C) sphingomyelin (component (C)) to component (A) (calculated as ergothioneine) is preferably 0.01 or more, more preferably 0.03 or more, further preferably 0.05 or more, further preferably 0.1 or more, and preferably 10 or less, more preferably 5 or less, further preferably 2 or less, further preferably 1.5 or less, and particularly preferably 1 or less. In one embodiment, the weight ratio ((C) / (A)) of (C) sphingomyelin to (A) ergothioneine or a salt thereof (component (A)) (calculated as ergothioneine) is preferably 0.01 to 10, more preferably 0.03 to 10, further preferably 0.03 to 5, further preferably 0.03 to 2, further preferably 0.03 to 1.5, particularly preferably 0.05 to 1.5, and most preferably 0.1 to 1.

[0019] The content of thioneine or its salt contained in the oral composition of the present invention is not particularly limited, and can be set according to its form, etc. The content of thioneine or its salt in the oral composition of the present invention is calculated with thioneine, for example, preferably more than 0.1% by weight in the composition, more preferably more than 0.5% by weight, further preferably more than 1% by weight, in addition, preferably less than 33% by weight, more preferably less than 20% by weight, further preferably less than 17% by weight, particularly preferably less than 10% by weight. In one embodiment, the content of thioneine or its salt is calculated with thioneine, preferably 0.1-33% by weight in the composition of the present invention, more preferably 0.5-20% by weight, further preferably 1-17% by weight, particularly preferably 1-10% by weight. When the composition of the present invention contains more than two compounds as thioneine or its salt, the content of thioneine or its salt refers to their total content. The content of thioneine can be measured by high performance liquid chromatography (HPLC).

[0020] The content of the milk-derived ceramide-containing raw material contained in the oral composition of the present invention is not particularly limited and can be appropriately set according to its form, etc. The content of the milk-derived ceramide-containing raw material in the oral composition of the present invention may be, for example, 0.01% by weight or more, preferably 0.2% by weight or more, more preferably 1.0% by weight or more in the composition, and may be 99% by weight or less, preferably 95% by weight or less, more preferably 90% by weight or less, further preferably 85% by weight or less, and further preferably 50% by weight or less. In one embodiment, the content of the milk-derived ceramide-containing raw material in the oral composition of the present invention is, for example, preferably 0.01 to 99% by weight, preferably 0.01 to 95% by weight, more preferably 0.2 to 90% by weight, further preferably 1.0 to 85% by weight, and further preferably 1.0 to 50% by weight. When the composition of the present invention contains two or more raw materials as milk-derived ceramide-containing raw materials, the content of the milk-derived ceramide-containing raw materials refers to their total content.

[0021] The content of sphingomyelin in the oral composition of the present invention is, for example, preferably 0.0001% by weight or more, more preferably 0.002% by weight or more, further preferably 0.01% by weight or more, and preferably 10% by weight or less, more preferably 5% by weight or less, further preferably 4% by weight or less, further preferably 3% by weight or less, and particularly preferably 2% by weight or less. In one embodiment, the content of sphingomyelin in the oral composition of the present invention is, for example, preferably 0.0001 to 10% by weight, more preferably 0.002 to 5% by weight, further preferably 0.01 to 4% by weight, further preferably 0.01 to 3% by weight, and particularly preferably 0.01 to 2% by weight. The content of sphingomyelin can be measured by HPLC.

[0022] The content of ergothioneine or a salt thereof in the composition of the present invention is preferably 1 to 100 mg, more preferably 2 to 50 mg, further preferably 5 to 25 mg, particularly preferably 5 to 20 mg, in terms of ergothioneine per daily intake for adults.

[0023] The content of the milk-derived ceramide-containing raw material in the composition of the present invention is preferably 2 to 5000 mg, more preferably 4 to 1000 mg, further preferably 10 to 500 mg, and particularly preferably 25 to 250 mg, based on the daily intake of an adult. In addition, the content of sphingomyelin in the composition of the present invention is preferably 0.04 to 1000 mg, more preferably 0.08 to 20 mg, further preferably 0.2 to 10 mg, and particularly preferably 0.5 to 5 mg, based on the daily intake of an adult.

[0024] The raw material containing ceramide of ergothioneine or its salt and milk source is contained in natural products or food and drink, and is the compound with edible experience.Therefore from the angle of safety, it is generally believed that the raw material containing ceramide of ergothioneine or its salt and milk source has less problems in daily intake, for example.According to the present invention, a kind of high safety can be provided, and the bad smell from the raw material containing ceramide of ergothioneine or its salt and milk source is suppressed and the composition that is easily taken in.

[0025] As described above, ergothioneine or its salt is known to exert a variety of physiological activities or health functions, for example, it is known to have an antioxidant effect, a brain function improvement effect, an anti-aging effect, an eye disease improvement effect, a whitening effect, an ultraviolet absorption effect, a melanin production inhibitory effect, an active oxygen elimination effect, an elastase activity inhibitory effect, a wrinkle formation inhibitory effect, a skin relaxation inhibitory effect, an autophagy promoting effect, etc. Therefore, the composition of the present invention can be suitably used for anti-oxidation, brain function improvement, anti-aging, eye disease, whitening, ultraviolet absorption, melanin production inhibition, active oxygen elimination, elastase activity inhibition, wrinkle formation inhibition, skin sagging inhibition, autophagy promotion, etc.

[0026] The milk-derived ceramide-containing raw material exhibits a moisturizing effect on the skin. Since the composition of the present invention contains the milk-derived ceramide-containing raw material, it can also be used to obtain the above-mentioned effect exerted by the milk-derived ceramide-containing raw material.

[0027] The composition of the present invention can be used for either therapeutic use (medical use) or non-therapeutic use (non-medical use). The term "non-therapeutic" refers to a concept that does not include medical behavior, that is, human surgery, treatment or diagnosis. The composition of the present invention is a composition for oral ingestion. As oral compositions, specifically, food and drink, oral pharmaceuticals, quasi-drugs, feeds, etc. can be cited. The composition of the present invention can be a raw material or preparation used by being deployed in these. The composition of the present invention is preferably a food and drink or an oral pharmaceutical, more preferably a food and drink.

[0028] As long as the effect of the present invention is not damaged, the composition of the present invention can also contain any additive, any component on the basis of the raw material containing ceramide in ergothioneine or its salt and milk source. These additives and components can be selected according to the form of the composition, and can use the material that can be generally used for oral compositions such as food and drink, pharmaceuticals, quasi-drugs, feeds. In one embodiment, the composition of the present invention can be a material consisting of the raw material containing ceramide in ergothioneine or its salt and milk source. The form of the oral composition of the present invention is not particularly limited, and may be solid (powder, granule, tablet, etc.), liquid, paste, or the like.

[0029] In one embodiment, when the composition of the present invention is made into food and drink, the raw material containing ceramide in ergothioneine or its salt and milk source can be used for food and drink (for example, food raw material, food additive used as required, etc.), and various food and drink are made. Food and drink are not particularly limited, and for example, general food and drink, health food, health supplement food, health drink, functional label food, specific health food, patient food and drink, etc. can be enumerated. Above-mentioned health food, health supplement food, functional label food, specific health food, etc., for example, can be used in the various preparation forms of granules, tablets, granules, powders, capsules, chewing agents, dry syrups, syrups, liquids, beverages, drinks, liquid foods, etc.

[0030] When the composition of the present invention is made into pharmaceuticals or quasi-medical products, for example, in the raw material containing ceramide in ergothioneine or its salt and milk source, the carrier allowed in pharmacology, the additive added as required, etc. are prepared, and the pharmaceuticals or quasi-medical products of various dosage forms are made. Such carriers, additives, etc., as long as they are materials allowed in the pharmacology that can be used for pharmaceuticals or quasi-medical products, for example, can be enumerated: one or more than two kinds of excipients, binding agents, disintegrants, lubricants, antioxidants, coloring agents, etc. As the dosage form for oral administration of pharmaceuticals or quasi-medical products, can be enumerated: liquid, tablet, powder, fine granules, granules, sugar-coated tablets, capsules, suspensions, emulsions, chewing agents, etc.

[0031] When the composition of the present invention is made into feed, ergothioneine or its salt and milk-derived ceramide-containing raw materials can be mixed into feed. Feed also includes feed additives. As feed, for example, feed for livestock such as cattle, pigs, chickens, sheep, horses, etc.; feed for small animals such as rabbits, rats, mice, etc.; pet food for dogs, cats, birds, etc., etc.

[0032] The subject to which the composition of the present invention is ingested or administered (may also be referred to as the subject to be administered) is not particularly limited, but is preferably a human or a non-human mammal, and more preferably a human.

[0033] The manufacturing method of the oral composition of the present invention is not particularly limited, for example, (A) ergothioneine or its salt and (B) milk-derived raw materials containing ceramide can be prepared by mixing them into the composition in a manner that their weight ratio reaches the above range. In the preparation of the oral composition containing (A) ergothioneine or its salt and (B) milk-derived raw materials containing ceramide, by adjusting the weight ratio ((B) / (A)) of component (B) relative to component (A) (ergothioneine conversion) to 2 to 70, a bitter taste from ergothioneine or its salt and a stench from the raw materials containing ceramide from milk can be obtained. The adjustment of the above-mentioned weight ratio can be carried out by adjusting the deployment amount of each component.

[0034] The present invention also includes the following methods. A method for suppressing bitterness from ergothioneine or its salt and odor from a milk-derived ceramide-containing raw material, characterized in that, in an oral composition containing (A) ergothioneine or its salt (component (A)) and (B) a milk-derived ceramide-containing raw material (component (B)), the weight ratio ((B) / (A)) of component (B) to component (A) (calculated as ergothioneine) is adjusted to 2 to 70. In the preparation of the oral composition, by adjusting the weight ratio ((B) / (A)) of the component (B) to the component (A) (calculated as ergothioneine) within the above range, an oral composition can be obtained in which the bitter taste derived from ergothioneine or its salt and the odor derived from the milk-derived ceramide-containing raw material are suppressed.

[0035] By the above method, the bitter taste from ergothioneine or its salt and the odor from the raw material containing ceramide from milk can be effectively suppressed. By suppressing the uncomfortable fragrance (bitterness and odor) from the raw material containing ergothioneine or its salt and milk source ceramide, the taste of the oral composition can be improved. In the above method, ergothioneine or its salt, milk-derived raw materials containing ceramide and their preferred embodiments are the same as the above-mentioned oral composition of the present invention. The preferred range of the weight ratio ((B) / (A)) of component (B) relative to component (A) (converted according to ergothioneine) is also the same as the oral composition of the present invention. The content of (C) sphingomyelin (component (C)) in the milk-derived raw material containing ceramide, the preferred range of the weight ratio ((C) / (A)) of component (C) relative to component (A) (converted according to ergothioneine) is also the same as the above-mentioned composition of the present invention.

[0036] According to the above method, bitterness derived from ergothioneine or a salt thereof and odor derived from a milk-derived ceramide-containing raw material can be suppressed, and the method can be used in combination with other bitterness suppression methods and / or odor suppression methods. Other methods for suppressing bitterness or odor include, for example, a method of adding a sweetener or a flavoring agent to a bitter or odorous ingredient to prepare a formulation; a method of coating a bitter or odorous ingredient with a sugar coating to prepare a formulation; or a method of sealing in a capsule to prepare a formulation.

[0037] The milk-derived ceramide-containing raw material is useful for suppressing the bitterness of ergothioneine or its salt. The present invention also includes an application of the above-mentioned milk-derived ceramide-containing raw material, which is used to suppress the bitterness from ergothioneine or its salt. In terms of the amount of the milk-derived ceramide-containing raw material used, it is preferably an amount in which the weight ratio ((B) / (A)) of the milk-derived ceramide-containing raw material relative to (A) ergothioneine or its salt (ergothioneine conversion) reaches 2 to 70.

[0038] Ergothioneine or its salt is useful for suppressing the odor of a raw material containing ceramide derived from milk. The present invention includes an application of ergothioneine or its salt for suppressing the odor of a raw material containing ceramide derived from milk. As for the amount of ergothioneine or its salt used, it is preferably an amount in which the weight ratio ((B) / (A)) of the raw material containing ceramide derived from milk to (A) ergothioneine or its salt (converted into ergothioneine) reaches 2 to 70.

[0039] In this specification, the numerical range represented by the lower limit and the upper limit, i.e., "lower limit - upper limit", includes the lower limit and the upper limit. For example, the range represented by "1 to 2" means 1 or more and 2 or less, including 1 and 2. In this specification, the upper limit and the lower limit can be set as a range of any combination. Example

[0040] The present invention will be described in more detail below based on examples. However, the present invention is not limited to these examples.

[0041] The materials used in the following evaluation tests are as follows. (A) Ergothioneine: Raw material containing 100% L-ergothioneine (B) Milk-derived ceramide-containing raw material: ceramide-containing whey powder containing 2% by weight of sphingomyelin (Milk Ceramide PLC, manufactured by Tatua Co-operative Dairy Co., Ltd.) (B) The milk-derived ceramide-containing raw material does not contain dextrin.

[0042] <Example 1> The raw materials of (A) and (B) in the amounts shown in Table 1 were mixed to prepare compositions of samples 1 to 6 (compositions containing ergothioneine and a milk-derived ceramide-containing raw material). The weight ratio of (B) / (A) in the compositions of samples 1 to 6 is shown in Table 1. "(C) Sphingomyelin (mg)" in Table 1 is the content of sphingomyelin in the sample. The weight ratio of (C) sphingomyelin / (A) ergothioneine ((C) / (A)) in the compositions of samples 1 to 6 is also shown in Table 1.

[0043] Three panelists skilled in sensory evaluation placed the total amount of the prepared composition (e.g., 20 mg in total, including 10 mg of ergothioneine and 10 mg of the milk-derived ceramide-containing raw material in Sample 1) directly on the tongue, and evaluated the bitterness intensity from ergothioneine and the odor intensity from the milk-derived ceramide-containing raw material according to the following criteria.

[0044] Evaluation criteria for bitterness from (A) ergothioneine By following benchmark with 1~5 points (5 grades), evaluate the bitterness from thioneine.As benchmark score, the bitterness intensity containing only above-mentioned (A) thioneine (10mg) is set to 5 points (control group 1).The evaluation of 3 assessors is counted, and mean value is shown in the evaluation result of table 1. 5 points: Strong bitterness from ergothioneine 4 points: Feel the bitter taste from ergothioneine 3 points: Slightly bitter taste from ergothioneine 2 points: The bitter taste from ergothioneine is not noticeable 1 point: No bitter taste from ergothioneine

[0045] (B) Evaluation criteria for odor from milk-derived ceramide-containing raw materials The odor from the milk-derived ceramide-containing raw material was evaluated with 1 to 5 points (5 levels) according to the following criteria. As the benchmark score, the odor intensity (milk-like fishy odor) of the raw material containing only the above-mentioned (B) milk-derived ceramide (10 mg, containing 0.2 mg of sphingomyelin) was set to 5 points (control group 2). The evaluations of the three panelists were counted, and the average value is shown in the evaluation results of Table 1. 5 points: Strong odor from milk-derived ceramide-containing raw materials 4 points: The smell of milk-derived ceramide-containing raw materials is felt 3 points: Slightly smells from milk-derived ceramide-containing ingredients 2 points: The odor from the milk-derived ceramide-containing raw materials is not too noticeable 1 point: No odor from milk-derived ceramide-containing raw materials

[0046] When the average values ​​of the evaluation of the bitterness derived from ergothioneine and the evaluation of the odor derived from the milk-derived ceramide-containing raw material are both less than 3.0 points, it is evaluated that the bitterness derived from ergothioneine and the odor derived from the milk-derived ceramide-containing raw material are suppressed.

[0047] [Table 1]

[0048] When the raw material containing ceramide in milk source is not allotted, the bitter taste of thioneine piercing the tongue can be strongly felt (control group 1). On the other hand, when only the raw material containing ceramide in milk source is used, the odor of the raw material containing ceramide in milk source can be strongly felt (control group 2). In samples 2 to 4 and sample 6, the bitter taste from thioneine and the odor from the raw material containing ceramide in milk source are both effectively alleviated.

Claims

1. An oral composition, characterized in that Contains the following ingredients (A) and (B): (A) ergothioneine or a salt thereof, and (B) a milk-derived ceramide-containing raw material, The weight ratio of the component (B) to the component (A) (calculated as ergothioneine), that is, (B) / (A) is 2 to 70.

2. The composition according to claim 1, characterized in that The weight ratio of the component (B) to the component (A) (calculated as ergothioneine), that is, (B) / (A) is 3 to 60.

3. The composition according to claim 1 or 2, characterized in that (B) The milk-derived ceramide-containing raw material is ceramide-containing whey powder.

4. The composition according to claim 1 or 2, characterized in that The milk-derived ceramide-containing raw material (B) contains (C) sphingomyelin, and the weight ratio of (C) sphingomyelin to the component (A) (calculated as ergothioneine), that is, (C) / (A) is 0.01 to 10.

5. The composition according to claim 1 or 2, characterized in that Milk is cow's milk.

6. The composition according to claim 1 or 2, characterized in that It is a food and drink.

7. A method for suppressing bitterness derived from ergothioneine or its salt and odor derived from a raw material containing ceramide derived from milk, characterized in that: In an oral composition containing the following ingredients (A) and (B): (A) ergothioneine or a salt thereof, and (B) a milk-derived ceramide-containing raw material, The weight ratio of the component (B) to the component (A) (calculated as ergothioneine), that is, (B) / (A) is adjusted to 2 to 70.

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