Cleaning composition containing chloroxylenol and application

Abstract

The invention belongs to the field of daily chemicals, and discloses a cleaning composition containing chloroxylenol, the cleaning composition is a water system surface active system, and the water system surface active system contains chloroxylenol and sodium lauryl sulfate; the water system surface activity system contains 1 to 6.5 weight percent of sodium lauryl sulfate. The composition contains chloroxylenol and sodium lauryl sulfate, and the chloroxylenol and the sodium lauryl sulfate are synergistically combined, so that a good sterilization effect can be achieved. Meanwhile, the invention further discloses application of the composition.

Description

Technical Field

[0001] The invention relates to the field of daily chemicals, in particular to a cleaning composition containing chloroxylenol and its application. Background Art

[0002] Currently, the fungicides used in cleaning products on the market are mostly triclosan, triclocarban, piroctone ethanolamine salt, sodium hypochlorite, etc. According to the literature, triclosan and triclocarban may have reproductive genetic toxicity to organisms and pose certain risks; piroctone ethanolamine salt has no reproductive genetic toxicity, but is easily oxidized and ineffective, and the combination of chloroxylenol and surfactants can easily make the antibacterial properties of the package ineffective; sodium hypochlorite bleaching ingredients have strong oxidizing effects, are highly alkaline and corrosive.

[0003] Chloroxylenol is a phenolic antibacterial agent, which is widely used in disinfectant water. It is mild to the skin and highly safe. However, as a traditional phenolic antibacterial agent, chloroxylenol has not been widely used in washing products at present, because chloroxylenol antibacterial agent has poor compatibility with surfactants and its antibacterial activity is easily reduced by surfactants, resulting in antibacterial failure.

[0004] The relevant literature on chloroxylenol in toiletries can be found as follows:

[0005] CN117815157A, a skin care composition, preparation method, skin care product and application, chloroxylenol is used as a preservative;

[0006] CN117643554A, low-irritation high-foaming skin cleansing composition and preparation method thereof, chloroxylenol is used as a preservative;

[0007] CN112075432A, a nicotinamide composite bactericide, its preparation method and application, chloroxylenol and nicotinamide are used as the composite bactericide.

[0008] In the prior art, no solution has addressed the problem that chloroxylenol is easily ineffective in surfactants, nor has any related technology addressed the problem of how to further enhance the antibacterial efficacy of chloroxylenol in surfactant systems.

[0009] Therefore, the technical problem solved in this case is: how to fully exert or enhance the antibacterial properties of chloroxylenol in the surfactant system. Summary of the invention

[0010] The object of the present invention is to provide a cleaning composition containing chloroxylenol. The composition contains chloroxylenol and sodium lauryl sulfate, and the synergistic combination of the two can achieve a good bactericidal effect.

[0011] Meanwhile, the invention also discloses the application of the composition.

[0012] To achieve the above object, the present invention provides the following technical solutions:

[0013] A cleaning composition containing chloroxylenol, wherein the cleaning composition is an aqueous surfactant system, wherein the aqueous surfactant system contains chloroxylenol and sodium lauryl sulfate; the aqueous surfactant system contains 1 to 6.5 wt % of sodium lauryl sulfate, and preferably, the aqueous surfactant system contains 1 to 4 wt % of sodium lauryl sulfate.

[0014] Sodium lauryl sulfate is not only a commonly used anionic surfactant, but also has been reported in a small number of literatures to have slight antibacterial ability and no bactericidal ability. The conclusion of the relevant literature is further verified in the research of the present invention.

[0015] The invention adopts sodium lauryl sulfate and chloroxylenol for combined use, and can improve the antibacterial rate of Escherichia coli ATCC 25922 from 45% to more than 95% within 2 minutes, and improve the antibacterial rate of Staphylococcus aureus ATCC 6538 to more than 99.9%.

[0016] The relevant mechanism is not clear yet, but we have verified through experiments that other anionic surfactants cannot improve the antibacterial ability when used in combination with chloroxylenol. Therefore, we believe that the obvious improvement in the antibacterial ability of chloroxylenol is not directly related to the use of anionic surfactants. We believe that it has a certain relationship with the slight antibacterial ability of sodium lauryl sulfate itself, but we are not clear about the antibacterial channel of the slight antibacterial ability of sodium lauryl sulfate, so we cannot give further explanation for the synergistic enhancement phenomenon.

[0017] In the above-mentioned cleaning composition, the water-based surfactant system further contains one or a combination of potassium cocoyl glycinate and acrylic acid (esters) / stearyl alcohol polyether-20 methacrylate copolymer AG-U8.

[0018] Potassium cocoyl glycinate is an anionic surfactant, and there is no literature reporting that it has antibacterial ability. When it is added to the emulsification system of the present invention, the antibacterial rate of Escherichia coli in sodium lauryl sulfate and chloroxylenol can be increased from 98.5% to 99.9%, achieving complete antibacterial effect.

[0019] Through the functional verification of sodium lauryl sulfate and potassium cocoyl glycinate, it can be seen that if other anionic surfactants are used to replace sodium lauryl sulfate, the antibacterial ability of chloroxylenol cannot be significantly improved; in the presence of sodium lauryl sulfate, the antibacterial ability of chloroxylenol can be further improved by optimizing other anionic surfactants;

[0020] Therefore, it can be concluded that the improvement of the antibacterial ability of chloroxylenol is closely related to the presence of sodium lauryl sulfate. On this basis, the addition of other anionic surfactants can further improve the antibacterial ability of chloroxylenol to a certain extent.

[0021] Acrylates / stearyl alcohol polyether-20 methacrylate copolymer AG-U8 is a surfactant and also a thickener, which has at least three functions in the system of the present invention: thickening, enhancing system stability at low temperatures, and enhancing antibacterial properties;

[0022] When acrylic acid (ester) / stearyl alcohol polyether-20 methacrylate copolymer AG-U8 is used in the system, the antibacterial ability of the system is improved from 95% to 99.9% against Escherichia coli, achieving complete antibacterial effect.

[0023] In summary, under the premise of the presence of sodium lauryl sulfate, anionic surfactants are preferred, and thickeners are preferably used to improve the system at normal low temperature conditions, which can significantly improve the antibacterial ability of chloroxylenol.

[0024] In the above cleaning composition, the aqueous surfactant system contains 0-4 wt % of potassium cocoyl glycinate, preferably, contains 0.5-4 wt % of potassium cocoyl glycinate.

[0025] In the above-mentioned cleaning composition, the aqueous surfactant system contains 0 to 4 wt % of acrylates / stearyl alcohol polyether-20 methacrylate copolymer AG-U8, preferably 1 to 4 wt % of acrylates / stearyl alcohol polyether-20 methacrylate copolymer AG-U8.

[0026] In the above cleaning composition, the aqueous surfactant system includes a surfactant and water; the surfactant is a combination of one or more of anionic surfactants, zwitterionic surfactants and nonionic surfactants.

[0027] The cleaning composition according to claim 5, characterized in that the anionic surfactant is one or more combinations of sodium laureth sulfate, sodium C8-C18 polyether sulfate, sodium tridecyl alcohol polyether sulfate, etc.;

[0028] The zwitterionic surfactant is one or more combinations of cocamidopropyl betaine, C8-C18 alkyl betaine, C8-C18 amide hydroxysulfonate, and C8-C18 alkyl hydroxysulfonate;

[0029] The nonionic surfactant is one or more combinations of cocamide DEA, cocamide MEA, and cocamide methyl MEA in the above-mentioned cleaning composition, and the water-based surfactant system also includes one or more combinations of fragrance, preservatives, chelating agents, moisturizers, and sodium chloride.

[0030] More specifically, the system of the present invention comprises the following components:

[0031] Acrylates / stearyl alcohol polyether-20 methacrylate copolymer: 1-4wt%;

[0032] Sodium lauryl sulfate: 1-4wt%;

[0033] Sodium laureth sulfate: 11-18wt%;

[0034] Cocamidopropyl amidopropyl betaine: 2-6wt%;

[0035] Chloroxylenol: 0.2-0.3wt%;

[0036] Potassium cocoyl glycinate: 0.5-4wt%;

[0037] And appropriate amounts of chelating agents, propylene glycol, pH adjusters, preservatives, flavors, sodium chloride and other additives;

[0038] The balance of water was added to 100%.

[0039] At the same time, the present invention also discloses the use of any of the above-mentioned cleaning compositions to prepare cleaning cosmetics.

[0040] In the above-mentioned use, the cleansing cosmetic product is hand soap, shower gel or shampoo.

[0041] Compared with the prior art, the present invention has the following beneficial effects:

[0042] The present invention adopts the synergistic combination of chloroxylenol and sodium lauryl sulfate to achieve a good bactericidal effect. DETAILED DESCRIPTION

[0043] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0044] The relevant original sources of the present invention are described as follows:

[0045] Disodium EDTA: Supplier: Akzo Nobel;

[0046] Sodium laureth sulfate (RSAW ESB70 / ZA): Supplier: Guangdong Lichen Aowei Industrial Co., Ltd.;

[0047] Sodium lauryl sulfate (LXNS / ZA): Supplier: Guangdong Lichen Aowei Industrial Co., Ltd.;

[0048] Cocamidopropyl amidopropyl betaine (CAB-35): Supplier: Guangzhou Xingye Technology Co., Ltd.;

[0049] Chloroxylenol (PCMX): Supplier: Guangdong Dimei Biotechnology Co., Ltd.;

[0050] Potassium cocoyl glycinate YCK-30K: Supplier: Nanjing Huashi New Materials Co., Ltd.;

[0051] Acrylates / Steareth-20 Methacrylate Copolymer AG-U8: Supplier: Foshan Green Source Biotechnology Co., Ltd.;

[0052] Benzalkonium chloride: Supplier: Guangdong Yeshi Industrial Co., Ltd.

[0053] Kasong: Supplier: Guangdong Dimei Biotechnology Co., Ltd.

[0054] Diaminopropyl dodecylamine: Supplier: Ningbo Xiangshen Biochemical Co., Ltd.

[0055] Part 1: Antibacterial hand cleaning composition containing chloroxylenol

[0056] The preparation process is as follows:

[0057] Pretreatment: PCMX and propylene glycol are heated and dissolved;

[0058] 1. Add disodium EDTA, AG-U8, and LXNS / ZA into water and stir to dissolve. Add sodium hydroxide and stir to dissolve.

[0059] 2. Add RSAW ESB70 / ZA and CAB-35 and stir to dissolve, then add the pre-treated antibacterial agent and YCK-30K and stir to dissolve;

[0060] 3. Add preservatives and flavors and stir to dissolve;

[0061] 4. Adjust pH and viscosity.

[0062] The test formula is shown in Table 1 below;

[0063] Table 1 Formula Unit: g

[0064]

[0065]

[0066]

[0067] Performance Testing:

[0068] Test items include:

[0069] Stability: Refer to GB / T 34855 method, test for 7 weeks;

[0070] Bacterial inhibition rate at room temperature: refer to QB / T 2738, Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 6538; action concentration stock solution, action time 2 minutes.

[0071] The test results can be found in Table 2 below;

[0072] Table 2 Test results

[0073]

[0074] Through the above test results, we can draw the following conclusions:

[0075] 1. It can be seen from Comparative Example 2 that in the absence of chloroxylenol, the antibacterial effect of the system is very poor, indicating that sodium lauryl sulfate in the system can only exert a weak antibacterial effect, which is consistent with the conclusion reported in the literature.

[0076] 2. It can be seen from Comparative Example 1 that in the absence of sodium lauryl sulfate, the antibacterial effect on Escherichia coli ATCC 25922 is reduced to less than 50%, indicating that sodium lauryl sulfate can effectively improve the antibacterial performance of chloroxylenol, proving that there is an antibacterial synergistic effect between the two.

[0077] 3. It can be seen from Examples 1-4 and Examples 5 and 6 that potassium cocoyl glycinate, acrylic acid (esters) / stearyl alcohol polyether-20 methacrylate copolymer AG-U8 are correlated with the temperature stability of the system, and both can at least increase the antibacterial effect of chloroxylenol on Escherichia coli by one order of magnitude.

[0078] 4. It can be seen from Examples 1-5 and Example 6 that acrylic acid (esters) / stearyl alcohol polyether-20 methacrylate copolymer AG-U8 is a key factor in achieving low temperature stability.

[0079] 5. It can be seen from Comparative Examples 3 and 4 that the antibacterial effect of the present invention cannot be achieved by using other surfactants with similar or even better antibacterial effects. The reason may be that the above-mentioned synergistic mechanism does not exist, or the stability of the system is not as good as that of the present invention, resulting in a poor antibacterial effect.

[0080] At the same time, during the research process of the present invention, we found that the following emulsifiers are not recommended to be added to the emulsification system. These emulsifiers will damage the antibacterial activity of chloroxylenol and make the antibacterial activity of chloroxylenol ineffective. The specific emulsifiers are: laureth-7, laureth-9, C12-15 alkylene ether-7, and C12-15 alkylene ether-9.

[0081] Part II Safety Testing

[0082] The cosmetic safety test for Examples 1-5 was changed to: a complete skin irritation test, the test method is: "Disinfection Technical Specifications 2002 Edition, Part 2 2.3.3

[0083] The test results are shown in Table 3;

[0084] Table 3 Irritation test results

[0085]

[0086]

[0087] Part III Other Application Formulations

[0088] The present invention is not limited to the formulations described in Table 1 of the first part. The water-based surfactant system of the present invention can be implemented in more forms, as shown in the following Table 4;

[0089] Table 4 Recipe

[0090]

[0091]

Claims

1. A cleaning composition containing chloroxylenol, characterized in that: The cleaning composition is a water-based surfactant system, which contains chloroxylenol and sodium lauryl sulfate; the water-based surfactant system contains 1-6.5 wt % of sodium lauryl sulfate.

2. The cleaning composition according to claim 1, characterized in that The water-based surfactant system also contains one or a combination of two of potassium cocoyl glycinate and acrylic acid (ester) / stearyl alcohol polyether-20 methacrylate copolymer AG-U8.

3. The cleaning composition according to claim 2, characterized in that The aqueous surfactant system contains 0.5-4 wt % of potassium cocoyl glycinate; the aqueous surfactant system contains 1-4 wt % of acrylic acid (ester) / stearyl alcohol polyether-20 methacrylate copolymer AG-U8.

4. The cleaning composition according to claim 1, characterized in that The water-based surfactant system contains 1-4 wt% of sodium lauryl sulfate.

5. The cleaning composition according to claim 1, characterized in that The aqueous surfactant system comprises a surfactant and water; the surfactant is a combination of one or more of anionic surfactants, zwitterionic surfactants and nonionic surfactants.

6. The cleaning composition according to claim 5, characterized in that The anionic surfactant is one or more combinations of sodium lauryl alcohol polyether sulfate, sodium C8-C18 polyether sulfate, and sodium tridecyl alcohol polyether sulfate; The zwitterionic surfactant is one or more combinations of cocamidopropyl betaine, C8-C18 alkyl betaine, C8-C18 amide hydroxysulfonate, and C8-C18 alkyl hydroxysulfonate; The nonionic surfactant is one or more combinations of cocamide DEA, cocamide MEA, and cocamide methyl MEA.

7. The cleaning composition according to claim 1, characterized in that The water-based surfactant system also includes one or more combinations of flavors, preservatives, chelating agents, moisturizers, and sodium chloride.

8. The cleaning composition according to claims 1 to 7, characterized in that The water-based surfactant system contains 0.2-0.3 wt % of chloroxylenol.

9. Use of the cleaning composition according to any one of claims 1 to 8 in preparing cleansing cosmetics.

10. The use according to claim 9, characterized in that The cleansing cosmetics are hand soap, shower gel or shampoo.

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