High-softness skin-friendly sanitary towel and preparation method thereof

Abstract

The invention relates to the field of hygienic products, provides a high-softness skin-friendly sanitary napkin and a preparation method thereof, and solves the problems that an existing sanitary napkin is poor in antibacterial component attachment effect, cannot specifically inhibit vaginal harmful bacteria and promote the dominant position of vaginal beneficial bacteria in bacterial communities, does not have the function of releasing antibacterial components under specific conditions, and cannot be used for preparing the sanitary napkin. The problem that long-time contact between antibacterial components and vaginal skin cannot be reduced while efficient bacteriostasis is achieved, and the cytotoxicity is high is solved; the sanitary towel comprises a surface layer, a flow guide layer, a core body and a leakage-proof bottom film which are sequentially arranged from top to bottom, the surface layer is a modified pure cotton non-woven fabric, and the modified pure cotton non-woven fabric is obtained by dipping a pure cotton non-woven fabric in an antibacterial ingredient microcapsule mixed solution, rolling and then drying.

Description

Technical Field

[0001] The invention relates to the field of sanitary products, and in particular to a highly soft, skin-friendly sanitary napkin and a preparation method thereof. Background Art

[0002] With the rapid development of society, people's living standards are constantly improving, and functional sanitary napkins have gradually been favored by consumers. During the menstrual period, sanitary napkins receive a large amount of menstrual blood, which is composed of blood and detached and necrotic endometrium. It contains a variety of nutrients for bacterial reproduction. In addition, the sanitary napkin environment is humid and airtight, which makes it easy to breed a large number of bacteria. Before menstruation, the vaginal environment of women is in a weakly acidic environment with a pH value of about 3.8-4.4. The weakly acidic environment can effectively inhibit the reproduction of bacterial pathogens. During menstruation, the outflow of weakly alkaline menstrual blood destroys the acid-base balance of the vaginal environment and breaks the natural protective barrier of the vaginal environment, thereby increasing the risk of bacterial vaginal infection. Therefore, it is necessary to increase the antibacterial function of sanitary napkins. At present, the antibacterial treatment of sanitary napkins mostly uses broad-spectrum antibacterial ingredients, which indiscriminately kill harmful and beneficial bacteria in the vagina, causing normal flora disorders and breaking the natural protective barrier of the vaginal environment.

[0003] Chinese patent application No. 202211523283.9 discloses a method for preparing an antibacterial breathable sanitary napkin, wherein the prepared surface quick-permeation layer, antibacterial chip, middle absorbent core layer and leakproof bottom layer are cut to size and bonded together in order to prepare an antibacterial breathable sanitary napkin. The invention soaks the antibacterial chip in a Chinese medicine extract, which includes 4-10 parts of oregano concentrate, 3-5 parts of cinnamon concentrate, 6-12 parts of thyme concentrate, and 1-5 parts of tea leaf concentrate, 5-8 parts of Litsea cubeba essential oil and 4-7 parts of clove essential oil. Several Chinese medicine substances work synergistically to effectively inhibit the growth and reproduction of microorganisms, while protecting the skin and mucous membranes, reducing irritation, and avoiding skin itching. However, the sanitary napkin does not have the function of specifically inhibiting harmful vaginal bacteria, and it is difficult to maintain the balance of the beneficial bacterial flora. The antibacterial component does not have the function of slow release, and the adhesion effect of the antibacterial component on the non-woven material is relatively poor.

[0004] Chinese patent application No. 202410774282.4 discloses a skin care sanitary napkin containing shea butter essential oil microcapsules. The invention contains shea butter essential oil microcapsules in a hollow spherical shape. Shea butter essential oil is distributed in the continuous phase of the wall material. After menstrual blood, shea butter essential oil begins to be released and slowly released at body temperature, which has a good repair effect. In addition, the beeswax in phase A has a good antibacterial effect, and N-2-hydroxypropyl-3-trimethylammonium chloride chitosan also has a good antibacterial effect due to the introduction of quaternary ammonium groups. The two work synergistically to enhance the antibacterial effect of the sanitary napkin. In addition, N-2-hydroxypropyl-3-trimethylammonium chloride chitosan and sodium carboxymethyl cellulose give the microcapsules good water solubility and biocompatibility. When the composite film liquid prepared therefrom is sprayed on a non-woven fabric, good biocompatibility is shown, which enhances the adhesion effect of the microcapsules on the non-woven fabric material. However, the sanitary napkin does not have the function of specifically inhibiting harmful bacteria, and it is difficult to maintain the balance of the flora of beneficial bacteria. Summary of the invention

[0005] Therefore, in response to the above-mentioned problems, the present invention provides a highly soft and skin-friendly sanitary napkin and a preparation method thereof, which solves the problems that the antibacterial components of existing sanitary napkins have poor adhesion effect, cannot specifically inhibit harmful vaginal bacteria and promote the dominant position of beneficial vaginal bacteria in the bacterial community, do not have the function of releasing antibacterial components under specific conditions, cannot have both high efficiency in antibacterial properties and reduce the long-term contact between antibacterial components and vaginal skin, and have high cytotoxicity.

[0006] To achieve the above object, the present invention adopts the following technical solutions:

[0007] A highly soft, skin-friendly sanitary napkin, comprising a surface layer, a guide layer, a core body, and a leakproof bottom film arranged in sequence from top to bottom, wherein the surface layer is a modified pure cotton non-woven fabric, and the modified pure cotton non-woven fabric is obtained by dipping the pure cotton non-woven fabric in a mixed solution of antibacterial component microcapsules and then rolling and drying; the surface layer comprises the pure cotton non-woven fabric and the antibacterial component microcapsules adhered to the surface of the pure cotton non-woven fabric, and the antibacterial component microcapsules are a three-layer structure, comprising an outermost first composite layer, a second outermost second composite layer, and an innermost third composite layer; the first composite layer is polyacrylic acid-conjugated polydopamine, the second composite layer is hyaluronic acid-modified polylactic acid, and the third composite layer is a mixture of cis-9-unsaturated long-chain fatty acids and oregano essential oil;

[0008] The antibacterial component microcapsule mixture includes the following raw materials: cis-9-unsaturated long-chain fatty acids, oregano essential oil, hyaluronic acid, polylactic acid, dichloromethane, polyvinyl alcohol, polyacrylic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, N-hydroxysuccinimide, dopamine, ammonia water, and deionized water.

[0009] Furthermore, the first composite layer dissolves when in contact with weakly alkaline menstrual blood.

[0010] Furthermore, the second composite layer dissolves when contacted with bacterial extracellular hydrolases.

[0011] Furthermore, the first composite layer dissolves earlier than the second composite layer.

[0012] Furthermore, when the antibacterial component microcapsules are in contact with weakly alkaline menstrual blood and hyaluronidase secreted by bacteria at the same time, a mixture of cis-9-unsaturated long-chain fatty acids and oregano essential oil is released.

[0013] A method for preparing a highly soft, skin-friendly sanitary napkin comprises the following steps:

[0014] S1, preparation of composite antibacterial liquid: according to the weight ratio of cis-9-unsaturated long-chain fatty acid and oregano essential oil of 1:1-3, cis-9-unsaturated long-chain fatty acid and oregano essential oil were mixed uniformly to obtain a composite antibacterial liquid;

[0015] S2. Preparation of antibacterial component microcapsule suspension: weigh 1-10 parts by weight of hyaluronic acid and 10-30 parts by weight of deionized water, add hyaluronic acid to deionized water, stir and dissolve, and obtain a hyaluronic acid solution; add 1-10 parts by weight of polylactic acid to the hyaluronic acid solution, stir and dissolve to form a mixed solution of hyaluronic acid modified with polylactic acid, and then perform dialysis treatment to obtain a dialysate; add 10-30 parts by weight of the composite antibacterial solution and 45-60 parts by weight of dichloromethane to the dialysate, mix well as an oil phase; dissolve 10-30 parts by weight of polyvinyl alcohol in 100-300 parts by weight of deionized water as an aqueous phase, mix the oil phase and the aqueous phase well, react in a water bath for 1-3 hours, and then perform high-speed shear treatment to obtain an antibacterial component microcapsule suspension;

[0016] S3, preparation of PD powder: dissolve 15-30 parts by weight of polyacrylic acid in 150-300 parts by weight of deionized water, add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and N-hydroxysuccinimide as catalysts, mix well, react in an ice-water bath for 3-4 hours, then add dopamine, mix well, stir for 20-24 hours, then dialyze, and freeze-dry to obtain PD powder;

[0017] S4, preparation of antibacterial component microcapsules: dispersing the antibacterial component microcapsule suspension obtained in step S2 in an ammonia buffer solution to obtain a first mixed solution; dissolving the PD powder obtained in step S3 in deionized water to obtain a second mixed solution; slowly dropping the second mixed solution into the first mixed solution while stirring evenly, continuing stirring for 20-24 hours, performing a self-polymerization reaction of dopamine to form polydopamine, centrifuging to remove the supernatant, taking the precipitate and washing it with deionized water, and vacuum drying to obtain antibacterial component microcapsules;

[0018] S5, preparation of modified pure cotton non-woven fabric: dissolving the antibacterial component microcapsules obtained in step S4 in water, adjusting the pH to 6-6.5 to obtain a mixed solution of antibacterial component microcapsules, and then immersing the pure cotton non-woven fabric in the mixed solution of antibacterial component microcapsules, rolling and drying to obtain a modified pure cotton non-woven fabric;

[0019] S6. Preparation of highly soft and skin-friendly sanitary napkins: The modified pure cotton non-woven fabric is used as the surface layer of the sanitary napkin, and is compounded according to the structure of the surface layer, the guide layer, the core body, and the leak-proof bottom film from top to bottom to obtain the highly soft and skin-friendly sanitary napkins.

[0020] Furthermore, the dialysis treatment is carried out in a dialysis bag with a molecular weight cutoff of 3000-3500Da for 4-8 hours.

[0021] Furthermore, the water bath reaction is carried out in a magnetic stirring water bath with a water bath temperature of 40-60°C.

[0022] Furthermore, the high-speed shearing treatment is carried out in a high-speed shearing homogenizer at a rotation speed of 10000-12000 rpm.

[0023] Furthermore, the centrifugal treatment is carried out in a centrifuge at a speed of 5000-6000 r / min for 5-10 min.

[0024] By adopting the above technical solution, the beneficial effects of the present invention are:

[0025] 1. According to the English literature Vaginal Lactobacillus fatty acid response mechanisms reveal an ametabolite-targeted strategy for bacterial vaginosis treatment. Zhu, Meilin et al. Cell, Volume 187, Issue 19, 5413-5430. e29., it is shown that cis-9-unsaturated long-chain fatty acid components can selectively inhibit Lactobacillus inerts and promote beneficial Lactobacillus; using cis-9-unsaturated long-chain fatty acids and oregano essential oil as antibacterial components of sanitary napkins can effectively kill harmful vaginal bacteria in vitro, promote the dominant position of beneficial bacteria in the bacterial community, maintain the balance of vaginal microecology, and enhance the ability to resist harmful bacteria.

[0026] 2. Prepare pH and bacterial hydrolase dual-responsive double-shell antibacterial microcapsules. First, polylactic acid (PLA) modified with hyaluronic acid (HA), a substrate of bacterial extracellular hydrolase, is used as the wall material to embed the antibacterial component to obtain HA-PLA@antibacterial component microcapsule suspension; then, polyacrylic acid (PAA) and dopamine (DOPA) are conjugated to obtain PAA-DOPA; the HA-PLA@antibacterial component microcapsule suspension is dispersed in an ammonia buffer to obtain a first mixed solution; PAA-DOPA powder is dissolved in a deionized water buffer to obtain a first mixed solution. deionized water to obtain a second mixed solution; then, the second mixed solution is slowly added dropwise to the first mixed solution, HA and DOPA undergo amidation reaction on the surface of the antibacterial component microcapsules, and DOPA undergoes self-polymerization under weakly alkaline conditions to form polydopamine (PDA), and PAA-PDA is deposited outside the shell layer of the HA-PLA@antibacterial component microcapsules to form the outermost layer of the microcapsules. The reaction conditions of this process are mild and the operation is quick and convenient, and finally PAA-PDA@HA-PLA@antibacterial component microcapsules are obtained.

[0027] 3. The outermost layer of the antibacterial component microcapsule is PAA-PDA, which dissolves when it contacts weakly alkaline menstrual blood; the sub-outer layer of the antibacterial component microcapsule is HA-PLA. When HA contacts menstrual blood, the bacterial extracellular hydrolase in the menstrual blood reacts with HA, the sub-outer layer dissolves, and the antibacterial substances in the inner layer are released; therefore, the antibacterial component microcapsule can only release the antibacterial substances when it contacts weakly alkaline menstrual blood and hyaluronidase secreted by bacteria at the same time, and exerts a high-efficiency antibacterial effect, thereby reducing the contact time between the antibacterial component and the vaginal skin and reducing cytotoxicity. The sanitary napkin prepared by this technical solution has both high-efficiency antibacterial properties and reduces the long-term contact between the antibacterial component and the vaginal skin, and further increases the stability of the antibacterial component on the sanitary napkin. The selected microcapsule materials have the advantage of high biocompatibility and are very suitable for use during menstruation.

[0028] 4. PAA-PDA forms the outermost layer of the microcapsule, in which the catechol functional groups in the PDA structure form hydrogen bonds with the hydroxyl groups on the surface of the cotton fibers. Without the introduction of other adhesives, the antibacterial skin care nanocapsules and the pure cotton non-woven fabrics can be firmly bonded, reducing the use of other chemicals, improving the biocompatibility of the pure cotton non-woven fabrics, and reducing the risk of allergies and irritation. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 is a data graph of the cumulative release of antibacterial components under different conditions in Example 4 of the present invention;

[0030] Figure 2 1 is a morphological diagram showing the effect of the antibacterial component microcapsule solution on L929 cells in Example 7 of the present invention. DETAILED DESCRIPTION

[0031] Example 1

[0032] A method for preparing a highly soft, skin-friendly sanitary napkin comprises the following steps:

[0033] (1) Preparation of a composite antibacterial liquid: according to the weight ratio of cis-9-unsaturated long-chain fatty acid to oregano essential oil being 1:1, cis-9-unsaturated long-chain fatty acid and oregano essential oil are mixed uniformly to obtain a composite antibacterial liquid;

[0034] (2) Preparation of antibacterial component microcapsule suspension: Weigh 1 part by weight of hyaluronic acid and 10 parts by weight of deionized water, add hyaluronic acid to deionized water and stir to dissolve, to obtain a hyaluronic acid solution; add 1 part by weight of polylactic acid to the hyaluronic acid solution, stir to dissolve, to form a mixed solution of hyaluronic acid modified with polylactic acid, and then dialyze in a dialysis bag with a molecular weight cutoff of 3000Da for 4 hours to obtain a dialysate; add 10 parts by weight of the composite antibacterial solution and 45 parts by weight of dichloromethane to the dialysate and mix well as an oil phase; dissolve 10 parts by weight of polyvinyl alcohol in 100 parts by weight of deionized water as an aqueous phase, mix the oil phase and the aqueous phase well, react in a magnetic stirring water bath for 1 hour at a water bath temperature of 40°C, and then perform high-speed shearing in a high-speed shear homogenizer at a speed of 10,000 rpm to obtain an antibacterial component microcapsule suspension;

[0035] (3) Preparation of PD powder: 15 parts by weight of polyacrylic acid was dissolved in 150 parts by weight of deionized water, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and N-hydroxysuccinimide were added as catalysts, mixed well, reacted in an ice-water bath for 3 h, then dopamine was added, mixed well, stirred for 20 h, and then dialyzed in a dialysis bag with a molecular weight cutoff of 3000 Da for 4 h, and freeze-dried to obtain PD powder;

[0036] (4) Preparation of antibacterial component microcapsules: Disperse the antibacterial component microcapsule suspension obtained in step (2) in an ammonia buffer solution to obtain a first mixed solution; dissolve the PD powder obtained in step (3) in deionized water to obtain a second mixed solution; slowly drop the second mixed solution into the first mixed solution while stirring evenly, continue stirring for 20 hours, perform self-polymerization of dopamine to form polydopamine, centrifuge in a centrifuge at a speed of 5000 r / min for 5 minutes, remove the supernatant, take the precipitate and wash it with deionized water, and vacuum dry to obtain antibacterial component microcapsules;

[0037] (5) Preparation of modified pure cotton non-woven fabric: dissolving the antibacterial component microcapsules obtained in step (4) in water, adjusting the pH to 6, obtaining a mixed solution of antibacterial component microcapsules, and then immersing the pure cotton non-woven fabric in the mixed solution of antibacterial component microcapsules, rolling and drying, to obtain a modified pure cotton non-woven fabric;

[0038] (6) Preparation of highly soft and skin-friendly sanitary napkins: The modified pure cotton non-woven fabric is used as the surface layer of the sanitary napkin, and is compounded in a structure of the surface layer, the guide layer, the core body, and the leak-proof bottom film from top to bottom to obtain the highly soft and skin-friendly sanitary napkins.

[0039] The highly soft and skin-friendly sanitary napkin comprises a surface layer, a guide layer, a core body and a leakproof bottom film arranged in sequence from top to bottom, wherein the surface layer is a modified pure cotton non-woven fabric, and the modified pure cotton non-woven fabric is obtained by dipping the pure cotton non-woven fabric in a mixed liquid of antibacterial component microcapsules and then rolling and drying; the surface layer comprises the pure cotton non-woven fabric and the antibacterial component microcapsules adhered to the surface of the pure cotton non-woven fabric, and the antibacterial component microcapsules are a three-layer structure, comprising an outermost first composite layer, a second outermost second composite layer and an innermost third composite layer; the first composite layer is polyacrylic acid-conjugated polydopamine, the second composite layer is hyaluronic acid-modified polylactic acid, and the third composite layer is a mixture of cis-9-unsaturated long-chain fatty acids and oregano essential oil;

[0040] The antibacterial component microcapsule mixed solution includes the following raw materials: cis-9-unsaturated long-chain fatty acids, oregano essential oil, hyaluronic acid, polylactic acid, dichloromethane, polyvinyl alcohol, polyacrylic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, N-hydroxysuccinimide, dopamine, ammonia water, and deionized water;

[0041] The first composite layer dissolves when it contacts weak alkaline menstrual blood, the second composite layer dissolves when it contacts bacterial extracellular hydrolase, the first composite layer dissolves earlier than the second composite layer, and the antibacterial component microcapsules release a mixture of cis-9-unsaturated long-chain fatty acids and oregano essential oil when they contact weak alkaline menstrual blood and hyaluronidase secreted by bacteria at the same time.

[0042] Example 2

[0043] A method for preparing a highly soft, skin-friendly sanitary napkin comprises the following steps:

[0044] (1) Preparation of a composite antibacterial liquid: according to a weight ratio of cis-9-unsaturated long-chain fatty acid to oregano essential oil of 1:2, cis-9-unsaturated long-chain fatty acid and oregano essential oil were uniformly mixed to obtain a composite antibacterial liquid;

[0045] (2) Preparation of antibacterial component microcapsule suspension: Weigh 5 parts by weight of hyaluronic acid and 20 parts by weight of deionized water, add hyaluronic acid to deionized water and stir to dissolve, to obtain a hyaluronic acid solution; add 5 parts by weight of polylactic acid to the hyaluronic acid solution, stir to dissolve, to form a mixed solution of hyaluronic acid modified with polylactic acid, and then dialyze in a dialysis bag with a molecular weight cutoff of 3200Da for 6 hours to obtain a dialysate; add 20 parts by weight of the composite antibacterial solution and 50 parts by weight of dichloromethane to the dialysate and mix well as an oil phase; dissolve 20 parts by weight of polyvinyl alcohol in 200 parts by weight of deionized water as an aqueous phase, mix the oil phase and the aqueous phase well, react in a magnetic stirring water bath for 2 hours at a water bath temperature of 50°C, and then perform high-speed shearing in a high-speed shear homogenizer at a speed of 11000 rpm to obtain an antibacterial component microcapsule suspension;

[0046] (3) Preparation of PD powder: 25 parts by weight of polyacrylic acid was dissolved in 200 parts by weight of deionized water, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and N-hydroxysuccinimide were added as catalysts, mixed well, reacted in an ice-water bath for 3.5 h, then dopamine was added, mixed well, stirred for 22 h, and then dialyzed in a dialysis bag with a molecular weight cutoff of 3200 Da for 6 h, and freeze-dried to obtain PD powder;

[0047] (4) Preparation of antibacterial component microcapsules: Disperse the antibacterial component microcapsule suspension obtained in step (2) in an ammonia buffer solution to obtain a first mixed solution; dissolve the PD powder obtained in step (3) in deionized water to obtain a second mixed solution; slowly drop the second mixed solution into the first mixed solution while stirring evenly, continue stirring for 22 hours, perform self-polymerization of dopamine to form polydopamine, centrifuge in a centrifuge at a speed of 5500 r / min for 8 minutes, remove the supernatant, take the precipitate and wash it with deionized water, and vacuum dry to obtain antibacterial component microcapsules;

[0048] (5) Preparation of modified pure cotton non-woven fabric: dissolving the antibacterial component microcapsules obtained in step (4) in water, adjusting the pH to 6.2 to obtain a mixed solution of antibacterial component microcapsules, and then immersing the pure cotton non-woven fabric in the mixed solution of antibacterial component microcapsules, rolling and drying to obtain a modified pure cotton non-woven fabric;

[0049] (6) Preparation of highly soft and skin-friendly sanitary napkins: The modified pure cotton non-woven fabric is used as the surface layer of the sanitary napkin, and is compounded in a structure of the surface layer, the guide layer, the core body, and the leak-proof bottom film from top to bottom to obtain the highly soft and skin-friendly sanitary napkins.

[0050] The highly soft and skin-friendly sanitary napkin comprises a surface layer, a guide layer, a core body and a leakproof bottom film arranged in sequence from top to bottom, wherein the surface layer is a modified pure cotton non-woven fabric, and the modified pure cotton non-woven fabric is obtained by dipping the pure cotton non-woven fabric in a mixed liquid of antibacterial component microcapsules and then rolling and drying; the surface layer comprises the pure cotton non-woven fabric and the antibacterial component microcapsules adhered to the surface of the pure cotton non-woven fabric, and the antibacterial component microcapsules are a three-layer structure, comprising an outermost first composite layer, a second outermost second composite layer and an innermost third composite layer; the first composite layer is polyacrylic acid-conjugated polydopamine, the second composite layer is hyaluronic acid-modified polylactic acid, and the third composite layer is a mixture of cis-9-unsaturated long-chain fatty acids and oregano essential oil;

[0051] The antibacterial component microcapsule mixed solution includes the following raw materials: cis-9-unsaturated long-chain fatty acids, oregano essential oil, hyaluronic acid, polylactic acid, dichloromethane, polyvinyl alcohol, polyacrylic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, N-hydroxysuccinimide, dopamine, ammonia water, and deionized water;

[0052] The first composite layer dissolves when it contacts weak alkaline menstrual blood, the second composite layer dissolves when it contacts bacterial extracellular hydrolase, the first composite layer dissolves earlier than the second composite layer, and the antibacterial component microcapsules release a mixture of cis-9-unsaturated long-chain fatty acids and oregano essential oil when they contact weak alkaline menstrual blood and hyaluronidase secreted by bacteria at the same time.

[0053] Example 3

[0054] A method for preparing a highly soft, skin-friendly sanitary napkin comprises the following steps:

[0055] (1) Preparation of a composite antibacterial liquid: according to the weight ratio of cis-9-unsaturated long-chain fatty acid to oregano essential oil being 1:3, cis-9-unsaturated long-chain fatty acid and oregano essential oil were uniformly mixed to obtain a composite antibacterial liquid;

[0056] (2) Preparation of antibacterial component microcapsule suspension: 10 parts by weight of hyaluronic acid and 30 parts by weight of deionized water were weighed, and the hyaluronic acid was added to the deionized water and stirred to dissolve to obtain a hyaluronic acid solution; 10 parts by weight of polylactic acid was added to the hyaluronic acid solution, and stirred to dissolve to form a mixed solution of hyaluronic acid modified polylactic acid, and then dialyzed in a dialysis bag with a molecular weight cutoff of 3500Da for 8 hours to obtain a dialysate; 30 parts by weight of the composite antibacterial solution and 60 parts by weight of dichloromethane were added to the dialysate and mixed evenly as an oil phase; 30 parts by weight of polyvinyl alcohol was dissolved in 300 parts by weight of deionized water as an aqueous phase, and the oil phase and the aqueous phase were mixed evenly, and a water bath reaction was carried out in a magnetic stirring water bath for 3 hours at a water bath temperature of 60°C, and then a high-speed shearing treatment was carried out in a high-speed shear homogenizer at a speed of 12000 rpm to obtain an antibacterial component microcapsule suspension;

[0057] (3) Preparation of PAA-DOPA powder: 30 parts by weight of polyacrylic acid was dissolved in 300 parts by weight of deionized water, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and N-hydroxysuccinimide were added as catalysts, mixed well, reacted in an ice-water bath for 4 h, then dopamine was added, mixed well, stirred for 24 h, and then dialyzed in a dialysis bag with a molecular weight cutoff of 3500 Da for 8 h, and freeze-dried to obtain PD powder;

[0058] (4) Preparation of antibacterial component microcapsules: dispersing the antibacterial component microcapsule suspension obtained in step (2) in an ammonia buffer solution to obtain a first mixed solution; dissolving the PD powder obtained in step (3) in deionized water to obtain a second mixed solution; slowly dropping the second mixed solution into the first mixed solution while stirring evenly, and continuing stirring for 24 hours to allow dopamine to self-polymerize to form polydopamine, centrifuging in a centrifuge at a speed of 6000 r / min for 10 minutes, removing the supernatant, taking the precipitate and washing it with deionized water, and vacuum drying to obtain antibacterial component microcapsules;

[0059] (5) Preparation of modified pure cotton non-woven fabric: dissolving the antibacterial component microcapsules obtained in step (4) in water, adjusting the pH to 6.5 to obtain a mixed solution of antibacterial component microcapsules, and then immersing the pure cotton non-woven fabric in the mixed solution of antibacterial component microcapsules, rolling and drying to obtain a modified pure cotton non-woven fabric;

[0060] (6) Preparation of highly soft and skin-friendly sanitary napkins: The modified pure cotton non-woven fabric is used as the surface layer of the sanitary napkin, and is compounded in a structure of the surface layer, the guide layer, the core body, and the leak-proof bottom film from top to bottom to obtain the highly soft and skin-friendly sanitary napkins.

[0061] The highly soft and skin-friendly sanitary napkin comprises a surface layer, a guide layer, a core body and a leakproof bottom film arranged in sequence from top to bottom, wherein the surface layer is a modified pure cotton non-woven fabric, and the modified pure cotton non-woven fabric is obtained by dipping the pure cotton non-woven fabric in a mixed liquid of antibacterial component microcapsules and then rolling and drying; the surface layer comprises the pure cotton non-woven fabric and the antibacterial component microcapsules adhered to the surface of the pure cotton non-woven fabric, and the antibacterial component microcapsules are a three-layer structure, comprising an outermost first composite layer, a second outermost second composite layer and an innermost third composite layer; the first composite layer is polyacrylic acid-conjugated polydopamine, the second composite layer is hyaluronic acid-modified polylactic acid, and the third composite layer is a mixture of cis-9-unsaturated long-chain fatty acids and oregano essential oil;

[0062] The antibacterial component microcapsule mixed solution includes the following raw materials: cis-9-unsaturated long-chain fatty acids, oregano essential oil, hyaluronic acid, polylactic acid, dichloromethane, polyvinyl alcohol, polyacrylic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, N-hydroxysuccinimide, dopamine, ammonia water, and deionized water;

[0063] The first composite layer dissolves when it contacts weak alkaline menstrual blood, the second composite layer dissolves when it contacts bacterial extracellular hydrolase, the first composite layer dissolves earlier than the second composite layer, and the antibacterial component microcapsules release a mixture of cis-9-unsaturated long-chain fatty acids and oregano essential oil when they contact weak alkaline menstrual blood and hyaluronidase secreted by bacteria at the same time.

[0064] Example 4

[0065] like Figure 1As shown, in order to study the reactivity of the release of antibacterial components by dual stimulation of pH and hyaluronidase (HAase), PBS solutions with pH values ​​of 6.0 and 7.4, as well as hyaluronidase solutions with pH values ​​of 6.0 and HAase solutions with pH values ​​of 7.4 were prepared respectively, and the modified pure cotton non-woven fabric obtained in Example 1 was placed in 4 beakers respectively, and 200 mL of PBS solution with pH value of 6.0, 200 mL of PBS solution with pH value of 7.4, 200 mL of HAase solution with pH value of 6.0 and 200 mL of HAase solution with pH value of 7.4 were added to the 4 beakers respectively, and dialyzed, and the dialysate was taken at 0 h, 0.5 h, 1 h, 1.5 h, 2 h, 2.5 h, and 3 h, and the cumulative release of the antibacterial components under different conditions was determined at a wavelength of 275 nm.

[0066] The cumulative release of antibacterial components under different conditions is as follows Figure 1 As shown. In the absence of HAase, in PBS at pH = 6.0 and pH = 7.4, only 10.8% and 14.0% of the antibacterial substances were released from the microcapsules within 3 hours; in the HAase solution at pH = 6.0, only 19.1% of the antibacterial substances were released from the microcapsules within 3 hours. Only in the HAase solution at pH = 7.4, the antibacterial components were significantly released, and the release rate reached 72.3% within 3 hours. Therefore, it can be seen that the release behavior of the antibacterial microcapsules is stimulated by both pH value and HAase.

[0067] Example 5

[0068] In order to study the antibacterial performance of antibacterial microcapsules against pathogenic bacteria, the inhibition zone method was used with reference to GB 15979-2002 "Hygiene Standards for Disposable Sanitary Products" and GB / T 39101-2020 "Inhibition Zone Method for Determination of Antibacterial Activity of Polypeptides" and modified. Staphylococcus aureus and other pathogenic bacteria indicator strains were used to determine the inhibitory activity. The indicator bacteria were inoculated from the cryopreserved tube into the specified culture medium, cultured at 37°C for 18 hours, and the indicator bacteria were diluted into a bacterial suspension of 1×105CFU / mL with PBS phosphate buffer with pH=7.4. The diluted indicator bacteria suspension was added to the specified culture medium at a volume fraction of 2%, and 20 mL was measured and poured into a sterilized plate after being fully stirred. The plate was gently shaken to evenly cover the culture medium. After solidification, the Oxford cup was placed at equal distances, and 150 μL of the antibacterial component microcapsule mixture obtained in Example 1, that is, the antibacterial component microcapsule solution, was taken with a pipette and slowly added to the Oxford cup. The sterilized plate was moved into a 4°C refrigerator for pre-diffusion for 12 hours, then taken out and placed in a 37°C incubator (indicator bacteria culture temperature) for constant temperature culture until the inhibition zone was clear. The inhibition zone method was used to determine the diameter of the inhibition zone. Each inhibition zone was measured 3 times in different directions, and the average value was recorded. The results of the antibacterial performance are shown in Table 1.

[0069] Table 1

[0070] Bacteria Diameter of inhibition zone (mm) Escherichia coli 22.86±0.47 Staphylococcus aureus 21.09±0.32 Candida albicans 18.42±0.51 Gardnerella vaginalis 20.57±0.20

[0071] As shown in Table 1, the antibacterial component microcapsules prepared by the technical solution have obvious inhibitory effects on potentially harmful bacteria (including Escherichia coli, Staphylococcus aureus, Candida albicans and Gardnerella vaginalis), and the diameter of the inhibition zone exceeds 15 mm.

[0072] Example 6

[0073] In order to verify the effect of antibacterial microcapsules on the common beneficial bacteria in vaginal flora, the experiment was divided into an experimental group and a control group. The culture medium used MRS liquid culture medium. The antibacterial microcapsule solution was added to the experimental group. The two groups of culture media were sterilized at 121°C for 15 minutes and then used. The experimental group and the control group were inoculated with 1×10 7 After culturing Lactobacillus crispatus and Lactobacillus gasseri at 37°C for 12 hours, the promoting effect of antibacterial microcapsules on beneficial Lactobacillus crispatus and Lactobacillus gasseri was evaluated by the number of viable bacteria. Calculation method: promotion multiple = number of viable bacteria in the experimental group / number of viable bacteria in the control group.

[0074] The results showed that the antibacterial component microcapsules of the present invention can promote the growth of common beneficial bacteria in vaginal flora, Lactobacillus crispatus and Lactobacillus gasseri, among which the promoting effect on Lactobacillus crispatus is close to 3.9 times, and the promoting effect on Lactobacillus gasseri is close to 3.4 times.

[0075] Example 7

[0076] like Figure 2 As shown, in order to study the cytotoxicity of the modified pure cotton non-woven fabric, referring to GB / T 16886.5-2017 "Biological Evaluation of Medical Devices Part 5: In Vitro Cytotoxicity Test", the biocompatibility of the modified pure cotton non-woven fabric was evaluated by detecting the effect of the antibacterial component microcapsule mixture (i.e., antibacterial component microcapsule solution) prepared in Example 1 on the survival rate of L929 cells.

[0077] Effects of antibacterial component microcapsule solution on L929 cell morphology Figure 2 As shown: the survival rate of L929 cells in the antibacterial component microcapsule solution prepared by the technical solution of the present application is 95.3%, and the cell morphology is almost unaffected, indicating that the modified pure cotton non-woven fabric for sanitary napkins prepared by the present invention has almost no cytotoxicity, which fully demonstrates its high biocompatibility.

[0078] Although the present invention has been specifically shown and described in conjunction with the preferred embodiments, it should be understood by those skilled in the art that various changes may be made to the present invention in form and details without departing from the spirit and scope of the present invention as defined by the appended claims, all of which are within the scope of protection of the present invention.

Claims

1. A highly soft, skin-friendly sanitary napkin, characterized in that: The invention comprises a surface layer, a guide layer, a core body and a leakproof bottom film which are arranged in sequence from top to bottom, wherein the surface layer is a modified pure cotton non-woven fabric, and the modified pure cotton non-woven fabric is obtained by dipping the pure cotton non-woven fabric in a mixed solution of antibacterial component microcapsules and rolling and then drying; the surface layer comprises the pure cotton non-woven fabric and the antibacterial component microcapsules adhered to the surface of the pure cotton non-woven fabric, and the antibacterial component microcapsules are a three-layer structure, comprising an outermost first composite layer, a second outermost second composite layer and an innermost third composite layer; the first composite layer is polyacrylic acid-conjugated polydopamine, the second composite layer is hyaluronic acid-modified polylactic acid, and the third composite layer is a mixture of cis-9-unsaturated long-chain fatty acids and oregano essential oil; The antibacterial component microcapsule mixture includes the following raw materials: cis-9-unsaturated long-chain fatty acids, oregano essential oil, hyaluronic acid, polylactic acid, dichloromethane, polyvinyl alcohol, polyacrylic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, N-hydroxysuccinimide, dopamine, ammonia water, and deionized water.

2. A highly soft, skin-friendly sanitary napkin according to claim 1, characterized in that: The first composite layer dissolves when it comes into contact with weakly alkaline menstrual blood.

3. A highly soft, skin-friendly sanitary napkin according to claim 1, characterized in that: The second composite layer dissolves upon contact with bacterial extracellular hydrolases.

4. A highly soft, skin-friendly sanitary napkin according to claim 1, characterized in that: The first composite layer dissolves earlier than the second composite layer.

5. A highly soft, skin-friendly sanitary napkin according to claim 1, characterized in that: When the antibacterial component microcapsules are in contact with weakly alkaline menstrual blood and hyaluronidase secreted by bacteria at the same time, a mixture of cis-9-unsaturated long-chain fatty acids and oregano essential oil is released.

6. A method for preparing a highly soft, skin-friendly sanitary napkin, characterized in that: The method comprises the following preparation steps: S1, preparation of composite antibacterial liquid: according to the weight ratio of cis-9-unsaturated long-chain fatty acid and oregano essential oil of 1:1-3, cis-9-unsaturated long-chain fatty acid and oregano essential oil were mixed uniformly to obtain a composite antibacterial liquid; S2. Preparation of antibacterial component microcapsule suspension: weigh 1-10 parts by weight of hyaluronic acid and 10-30 parts by weight of deionized water, add hyaluronic acid to deionized water, stir and dissolve, and obtain a hyaluronic acid solution; add 1-10 parts by weight of polylactic acid to the hyaluronic acid solution, stir and dissolve to form a mixed solution of hyaluronic acid modified with polylactic acid, and then perform dialysis treatment to obtain a dialysate; add 10-30 parts by weight of the composite antibacterial solution and 45-60 parts by weight of dichloromethane to the dialysate, mix well as an oil phase; dissolve 10-30 parts by weight of polyvinyl alcohol in 100-300 parts by weight of deionized water as an aqueous phase, mix the oil phase and the aqueous phase well, react in a water bath for 1-3 hours, and then perform high-speed shear treatment to obtain an antibacterial component microcapsule suspension; S3, preparation of PD powder: dissolve 15-30 parts by weight of polyacrylic acid in 150-300 parts by weight of deionized water, add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and N-hydroxysuccinimide as catalysts, mix well, react in an ice-water bath for 3-4 hours, then add dopamine, mix well, stir for 20-24 hours, then dialyze, and freeze-dry to obtain PD powder; S4, preparation of antibacterial component microcapsules: dispersing the antibacterial component microcapsule suspension obtained in step S2 in an ammonia buffer solution to obtain a first mixed solution; dissolving the PD powder obtained in step S3 in deionized water to obtain a second mixed solution; slowly dropping the second mixed solution into the first mixed solution while stirring evenly, continuing stirring for 20-24 hours, performing a self-polymerization reaction of dopamine to form polydopamine, centrifuging to remove the supernatant, taking the precipitate and washing it with deionized water, and vacuum drying to obtain antibacterial component microcapsules; S5, preparation of modified pure cotton non-woven fabric: dissolving the antibacterial component microcapsules obtained in step S4 in water, adjusting the pH to 6-6.5 to obtain a mixed solution of antibacterial component microcapsules, and then immersing the pure cotton non-woven fabric in the mixed solution of antibacterial component microcapsules, rolling and drying to obtain a modified pure cotton non-woven fabric; S6. Preparation of highly soft and skin-friendly sanitary napkins: The modified pure cotton non-woven fabric is used as the surface layer of the sanitary napkin, and is compounded according to the structure of the surface layer, the guide layer, the core body, and the leak-proof bottom film from top to bottom to obtain the highly soft and skin-friendly sanitary napkins.

7. The method for preparing a highly soft, skin-friendly sanitary napkin according to claim 6, characterized in that: The dialysis treatment is carried out in a dialysis bag with a molecular weight cut-off of 3000-3500Da for 4-8 hours.

8. The method for preparing a highly soft, skin-friendly sanitary napkin according to claim 6, characterized in that: The water bath reaction is carried out in a magnetic stirring water bath pot at a water bath temperature of 40-60°C.

9. The method for preparing a highly soft, skin-friendly sanitary napkin according to claim 6, characterized in that: The high-speed shearing treatment is carried out in a high-speed shearing homogenizer at a rotation speed of 10000-12000 rpm.

10. The method for preparing a highly soft skin-friendly sanitary napkin according to claim 6, characterized in that: The centrifugal treatment is carried out in a centrifuge at a rotation speed of 5000-6000 r / min for 5-10 min.

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