DNA (deoxyribonucleic acid) modified gold and silver nano-composite particle as well as preparation method and application thereof

By modifying thiol DNA on the surface of silver-shell gold-core nanoparticles, DNA-modified gold-silver nanocomposite particles are formed, which solves the problem of easy agglomeration and instability of detection signals in the existing gold-silver nanosols, achieving higher dispersion, stability and Raman detection performance, and reducing biotoxicity.

CN119657907APending Publication Date: 2025-03-21THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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Patent Information

Application Number
CN202411697067.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-26
Publication Date
2025-03-21

AI Technical Summary

Technical Problem

The existing gold and silver nanosols have problems such as easy agglomeration, uneven distribution of "hot spots" and easy oxidation, resulting in unstable Raman detection signal, poor reproducibility and biotoxicity.

Method used

By modifying thiol DNA on the surface of silver-shell gold-core nanoparticles, DNA-modified gold-silver nanocomposite particles are formed to ensure the dispersion and stability of the nanomaterials, while forming an overall electrically neutral structure to avoid electrostatic interference.

Benefits of technology

It improves the dispersion and stability of nanomaterials, enhances the stability and reproducibility of Raman detection signals, reduces biotoxicity, and does not require additional storage requirements at room temperature. There is no obvious change in appearance and Raman enhancement performance after 60 days of storage.

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Abstract

The invention relates to a DNA (deoxyribonucleic acid) modified gold and silver nano composite particle, a preparation method and application. The DNA modified gold and silver nano composite particle comprises a silver shell and gold core nano particle and sulfydryl DNA modified on the surface of the silver shell and gold core nano particle. The invention also provides a preparation method of the DNA modified gold and silver nano composite particle, which comprises the following steps: dispersing gold nano particles in CTAB (cetyltrimethyl ammonium bromide), and sequentially adding sulfydryl DNA, silver salt, ascorbic acid and alkali in a stirring state to prepare the DNA modified gold and silver nano composite particle by a one-step method. The invention also provides an application of the DNA modified gold and silver nano composite particle as a probe in surface enhanced Raman scattering detection. The problems that existing gold and silver nano-sol is prone to agglomeration, uneven in hot spot distribution, prone to oxidation and the like are solved, and the problems that when the existing gold and silver nano-sol is used for Raman detection, detection is unstable, reproducibility is poor, and biotoxicity is poor are solved.
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