Biological antibacterial gel for balancing gynecological micro-ecological flora structure

Abstract

The invention discloses a biological antibacterial gel for balancing a gynecological micro-ecological flora structure and a preparation method of the biological antibacterial gel. Comprising the following raw materials in parts by weight: 0.1-0.3 part of bioactive peptide, 0.05-0.2 part of saponin, 2-4 parts of laurocapram, 15-20 parts of a traditional Chinese medicine extract, 0.5-1.5 parts of sodium hyaluronate, 0.1-0.25 part of plant essential oil, 1-3 parts of polyethylene glycol, 0.8-1.5 parts of lactic acid, 1-2 parts of carboxymethyl cellulose, 1-1.5 parts of glycerol, 1-2 parts of carbomer, 0.5-1.5 parts of an emulsifier and the balance of purified water, totaling 100 parts. The invention relates to the technical field of gynecological gel. According to the biological antibacterial gel for balancing the gynecological micro-ecological flora structure, ligusticum, asarum and dragon's blood are added into the raw materials of the traditional Chinese medicine extract, so that the use effect of an external medicine is greatly improved, and the growth of bacteria is inhibited; particularly, the compound has a good inhibiting effect on main staphylococcus aureus, escherichia coli and candida albicans in gynecologic inflammation, so that the compound has a better effect of balancing a gynecologic micro-ecological flora structure.

Description

Technical Field

[0001] The present invention relates to the technical field of gynecological gels, and specifically to a biological antibacterial gel for balancing the structure of gynecological microecological flora. Background Art

[0002] Female reproductive system diseases are gynecological diseases. Gynecological diseases have a wide range, including vulvar diseases, vaginal diseases, uterine diseases, fallopian tube diseases, ovarian diseases, etc. Gynecological diseases are common and frequently-occurring diseases in women. The main symptoms include increased vaginal discharge, vulvar pruritus. Acute adnexitis is also accompanied by symptoms such as abdominal pain and fever, and chronic adnexitis is accompanied by symptoms such as abdominal pain and increased leucorrhea. When treating such gynecological diseases, antibacterial gels are used.

[0003] Referring to the patent publication number "CN115554393A", it discloses a biological antibacterial gel for balancing the structure of gynecological microecological flora, and the characteristic substances included are a biological antibacterial solution containing lysozyme and caffeic acid. It is characterized in that: it further includes a composition composed of a shaping agent, a metal salt and a chelating agent. Among them, the shaping agent is AVC, the cation in the metal salt is Ca2+ or Mg2+, and the chelating agent is EGTA or EDTA.

[0004] As shown in the above technology, when the biological antibacterial gel is used, it is pushed into the vagina through a tool, which is actually a way of applying medicine externally. Then, when the gel takes effect, it is necessary to wait for the drug to penetrate. However, the existing biological antibacterial gel has insufficient antibacterial effect and low permeability, resulting in the need for patients to use the biological antibacterial gel multiple times. Summary of the Invention

[0005] Aiming at the deficiencies of the prior art, the present invention provides a biological antibacterial gel for balancing the structure of gynecological microecological flora, which solves the problems of poor antibacterial and absorption effects of the existing biological antibacterial gel.

[0006] To achieve the above objectives, the present invention is realized through the following technical solutions: A biological antibacterial gel for balancing the structure of gynecological microecological flora is prepared from the following raw materials by weight:

[0007] Bioactive peptides 0.1 - 0.3 parts, saponins 0.05 - 0.2 parts, laurocapram 2 - 4 parts, Chinese herbal medicine extract 15 - 20 parts, sodium hyaluronate 0.5 - 1.5 parts, plant essential oil 0.1 - 0.25 parts, polyethylene glycol 1 - 3 parts, lactic acid 0.8 - 1.5 parts, carboxymethyl cellulose 1 - 2 parts, glycerol 1 - 1.5 parts, carbomer 1 - 2 parts, emulsifier 0.5 - 1.5 parts, and purified water is added to make up to 100 parts;

[0008] The traditional Chinese medicine extract is made from the following raw materials in parts by weight: 8-10 parts of Sophora flavescens, 6-8 parts of Phellodendron amurense, 2-4 parts of Cnidium monnieri, 4-6 parts of Salvia miltiorrhiza, 4-6 parts of Carthamus tinctorius, 4-8 parts of Ligusticum sinense, 1-2 parts of Asarum sieboldii, and 6-9 parts of Dracaena cochinchinensis.

[0009] Preferably, by weight, it is made from the following raw materials in parts by weight:

[0010] 0.1 part of bioactive peptide, 0.05 part of saponin, 2 parts of laurocapram, 15 parts of traditional Chinese medicine extract, 0.5 part of sodium hyaluronate, 0.1 part of plant essential oil, 1 part of polyethylene glycol, 0.8 part of lactic acid, 1 part of carboxymethyl cellulose, 1 part of glycerol, 1 part of carbomer, 0.5 part of emulsifier, and purified water is added to make up 100 parts;

[0011] The traditional Chinese medicine extract is made from the following raw materials in parts by weight: 8 parts of Sophora flavescens, 6 parts of Phellodendron amurense, 2 parts of Cnidium monnieri, 4 parts of Salvia miltiorrhiza, 4 parts of Carthamus tinctorius, 4 parts of Ligusticum sinense, 1 part of Asarum sieboldii, and 6 parts of Dracaena cochinchinensis.

[0012] Preferably, by weight, it is made from the following raw materials in parts by weight:

[0013] 0.2 part of bioactive peptide, 0.1 part of saponin, 3 parts of laurocapram, 18 parts of traditional Chinese medicine extract, 1 part of sodium hyaluronate, 0.2 part of plant essential oil, 2 parts of polyethylene glycol, 1.2 parts of lactic acid, 1.5 parts of carboxymethyl cellulose, 1.25 parts of glycerol, 1.5 parts of carbomer, 1 part of emulsifier, and purified water is added to make up 100 parts;

[0014] The traditional Chinese medicine extract is made from the following raw materials in parts by weight: 9 parts of Sophora flavescens, 7 parts of Phellodendron amurense, 3 parts of Cnidium monnieri, 5 parts of Salvia miltiorrhiza, 5 parts of Carthamus tinctorius, 6 parts of Ligusticum sinense, 1.5 parts of Asarum sieboldii, and 8 parts of Dracaena cochinchinensis.

[0015] Preferably, by weight, it is made from the following raw materials in parts by weight:

[0016] 0.3 part of bioactive peptide, 0.2 part of saponin, 4 parts of laurocapram, 20 parts of traditional Chinese medicine extract, 1.5 parts of sodium hyaluronate, 0.25 part of plant essential oil, 3 parts of polyethylene glycol, 1.2 parts of lactic acid, 1.5 parts of carboxymethyl cellulose, 1 part of glycerol, 1.5 parts of carbomer, 1 part of emulsifier, and purified water is added to make up 100 parts;

[0017] The traditional Chinese medicine extract is made from the following raw materials in parts by weight: 10 parts of Sophora flavescens, 8 parts of Phellodendron amurense, 4 parts of Cnidium monnieri, 6 parts of Salvia miltiorrhiza, 6 parts of Carthamus tinctorius, 8 parts of Ligusticum sinense, 2 parts of Asarum sieboldii, and 9 parts of Dracaena cochinchinensis.

[0018] Preferably, Ligusticum sinense has the effects of analgesia, anti-inflammation, and improving hypoxia tolerance; Asarum sieboldii has the effects of analgesia, anti-inflammation, inhibiting pathogenic microorganisms, and anti-allergic reaction; Dracaena cochinchinensis has the effects of anti-thrombosis formation and improving blood rheology.

[0019] Preferably, the laurocapram is odorless, tasteless, and has the function of promoting drug absorption.

[0020] Preferably, the preparation process of the biological antibacterial gel comprises the following steps:

[0021] Step 1: Preparation of the first mixed solution: Mix the traditional Chinese medicine extract, bioactive peptide, saponin, and laurocapram with purified water and filter to obtain the first mixed solution;

[0022] Step 2: Preparation of the second mixed solution: Mix sodium hyaluronate, plant essential oil, polyethylene glycol, lactic acid, and carboxymethyl cellulose and filter to obtain the second filtrate;

[0023] Step 3: Preparation of the biological antibacterial gel: Mix glycerol, carbomer, emulsifier, the first mixed solution, and the second mixed solution thoroughly and stir evenly, then add purified water to a sufficient amount to obtain the gel.

[0024] Preferably, during the process of preparing the gel in Step 3, a pH value test is carried out, and a pH regulator is gradually added to make the test value between 4.5 and 7.0.

[0025] Beneficial effects

[0026] The present invention provides a biological antibacterial gel for balancing the structure of the gynecological microecological flora. Compared with the prior art, it has the following beneficial effects:

[0027] 1. The biological antibacterial gel for balancing the structure of the gynecological microecological flora greatly improves the use effect of external drugs and inhibits the growth of bacteria by adding ligusticum sinense, asarum, and dragon's blood to the raw materials of the traditional Chinese medicine extract. In particular, it has a good inhibitory effect on Staphylococcus aureus, Escherichia coli, and Candida albicans, which are the main ones in gynecological inflammation, thus having a better effect of balancing the structure of the gynecological microecological flora.

[0028] 2. The biological antibacterial gel for balancing the structure of the gynecological microecological flora increases the permeability of the biological antibacterial gel into the vagina by adding laurocapram, which is beneficial to the rapid absorption of antibacterial drugs, thereby greatly shortening the action time of the drugs and enhancing the antibacterial effect.

[0029] 3. The biological antibacterial gel for balancing the structure of the gynecological microecological flora strictly controls the pH value of the gel. The pH of the biological antibacterial gel is adjusted by gradually adding a pH regulator, thereby avoiding the influence of too high or too low pH on its action effect. Brief description of the drawings

[0030] Figure 1 It is a flowchart for the preparation of the biological antibacterial gel of the present invention. Detailed implementation mode

[0031] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0032] The biological antibacterial gel for balancing the structure of the gynecological microecological flora provides three implementation schemes:

[0033] It is made from the following raw materials in parts by weight:

[0034] Bioactive peptide 0.1 - 0.3 parts, saponin 0.05 - 0.2 parts, laurocapram 2 - 4 parts, traditional Chinese medicine extract 15 - 20 parts, sodium hyaluronate 0.5 - 1.5 parts, plant essential oil 0.1 - 0.25 parts, polyethylene glycol 1 - 3 parts, lactic acid 0.8 - 1.5 parts, carboxymethyl cellulose 1 - 2 parts, glycerol 1 - 1.5 parts, carbomer 1 - 2 parts, emulsifier 0.5 - 1.5 parts, and purified water is made up to 100 parts;

[0035] The traditional Chinese medicine extract is made from the following raw materials in parts by weight: Sophora flavescens 8 - 10 parts, Phellodendron amurense 6 - 8 parts, Fructus Cnidii 2 - 4 parts, Salvia miltiorrhiza 4 - 6 parts, Carthamus tinctorius 4 - 6 parts, Ligusticum sinense 4 - 8 parts, Asarum sieboldii 1 - 2 parts, and Dragon's blood 6 - 9 parts.

[0036] Ligusticum sinense has the effects of analgesia, anti - inflammation and improving the ability to tolerate hypoxia. Asarum sieboldii has the effects of analgesia, anti - inflammation, inhibiting pathogenic microorganisms and anti - allergic reaction. Dragon's blood has the effects of anti - thrombus formation and improving blood rheology. Laurocapram is odorless, tasteless and has the function of promoting drug absorption.

[0037] Embodiment 1:

[0038] Calculated by weight, it is made from the following raw materials in parts by weight:

[0039] Bioactive peptide 0.1 part, saponin 0.05 part, laurocapram 2 parts, traditional Chinese medicine extract 15 parts, sodium hyaluronate 0.5 part, plant essential oil 0.1 part, polyethylene glycol 1 part, lactic acid 0.8 part, carboxymethyl cellulose 1 part, glycerol 1 part, carbomer 1 part, emulsifier 0.5 part, and purified water is made up to 100 parts;

[0040] The traditional Chinese medicine extract is made from the following raw materials in parts by weight: Sophora flavescens 8 parts, Phellodendron amurense 6 parts, Fructus Cnidii 2 parts, Salvia miltiorrhiza 4 parts, Carthamus tinctorius 4 parts, Ligusticum sinense 4 parts, Asarum sieboldii 1 part, and Dragon's blood 6 parts.

[0041] The preparation process of the biological antibacterial gel includes the following steps:

[0042] Step 1: Preparation of the first mixture: Mix the traditional Chinese medicine extract, bioactive peptide, saponin, and laurocapram into purified water, and filter to obtain the first mixture.

[0043] Step 2: Preparation of the second mixture: Mix sodium hyaluronate, plant essential oil, polyethylene glycol, lactic acid, and carboxymethyl cellulose, and filter to obtain the second filtrate.

[0044] Step 3: Preparation of the biological antibacterial gel: Thoroughly mix and stir glycerol, carbomer, emulsifier, the first mixture, and the second mixture evenly, and then add purified water to a sufficient amount to obtain the gel.

[0045] During the process of preparing the gel in Step 3, perform a pH test, and gradually add a pH regulator to make the test value between 4.5 and 7.0.

[0046] Example 2:

[0047] It is made from the following raw materials by weight:

[0048] 0.2 parts of bioactive peptide, 0.1 part of saponin, 3 parts of laurocapram, 18 parts of traditional Chinese medicine extract, 1 part of sodium hyaluronate, 0.2 part of plant essential oil, 2 parts of polyethylene glycol, 1.2 parts of lactic acid, 1.5 parts of carboxymethyl cellulose, 1.25 parts of glycerol, 1.5 parts of carbomer, 1 part of emulsifier, and make up to 100 parts with purified water;

[0049] The traditional Chinese medicine extract is made from the following raw materials by weight: 9 parts of Sophora flavescens, 7 parts of Phellodendron amurense, 3 parts of Fructus Cnidii, 5 parts of Salvia miltiorrhiza, 5 parts of Carthamus tinctorius, 6 parts of Ligusticum sinense, 1.5 parts of Asarum sieboldii, and 8 parts of Dragon's blood.

[0050] Example 3:

[0051] It is made from the following raw materials by weight:

[0052] 0.3 parts of bioactive peptide, 0.2 part of saponin, 4 parts of laurocapram, 20 parts of traditional Chinese medicine extract, 1.5 parts of sodium hyaluronate, 0.25 part of plant essential oil, 3 parts of polyethylene glycol, 1.2 parts of lactic acid, 1.5 parts of carboxymethyl cellulose, 1 part of glycerol, 1.5 parts of carbomer, 1 part of emulsifier, and make up to 100 parts with purified water;

[0053] The traditional Chinese medicine extract is made from the following raw materials by weight: 10 parts of Sophora flavescens, 8 parts of Phellodendron amurense, 4 parts of Fructus Cnidii, 6 parts of Salvia miltiorrhiza, 6 parts of Carthamus tinctorius, 8 parts of Ligusticum sinense, 2 parts of Asarum sieboldii, and 9 parts of Dragon's blood.

[0054] Original formula: 0.2 parts of bioactive peptide, 0.1 part of saponin, 18 parts of traditional Chinese medicine extract, 1 part of sodium hyaluronate, 0.2 part of plant essential oil, 2 parts of polyethylene glycol, 1.2 parts of lactic acid, 1.5 parts of carboxymethyl cellulose, 1.25 parts of glycerol, 1.5 parts of carbomer, 1 part of emulsifier, and purified water to make up 100 parts;

[0055] The traditional Chinese medicine extract is made from raw materials including the following parts by weight: 9 parts of Sophora flavescens, 7 parts of Phellodendron amurense, 3 parts of Fructus Cnidii, 5 parts of Salvia miltiorrhiza, and 5 parts of Carthamus tinctorius.

[0056] Drug treatment effect experiment:

[0057] Three test strains are used for the test, including Staphylococcus aureus, Escherichia coli, and Candida albicans. The test is divided into four groups, namely Example 1, Example 2, Example 3, and the original formula. Among them, the substances with the same raw materials in the original formula and Example 2 maintain the same parts by weight, and the bacteriostatic rate is measured at 2 min, 5 min, 10 min, and 20 min of the test time.

[0058]

[0059]

[0060] From the tests in the above table, it can be known that the biological bacteriostatic gel provided by the present invention has excellent treatment ability, can quickly cure patients with gynecological inflammation, and relieve most critically ill patients. Among them, the weight components in Example 2 are the most excellent and are significantly better than the original formula.

[0061] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variant thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device.

[0062] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A biological antibacterial gel for balancing the structure of gynecological microecological flora, characterized by: The invention is made of the following raw materials in parts by weight: 0.1-0.3 parts of bioactive peptides, 0.05-0.2 parts of saponins, 2-4 parts of laurocapram, 15-20 parts of Chinese herbal extracts, 0.5-1.5 parts of sodium hyaluronate, 0.1-0.25 parts of plant essential oils, 1-3 parts of polyethylene glycol, 0.8-1.5 parts of lactic acid, 1-2 parts of carboxymethyl cellulose, 1-1.5 parts of glycerol, 1-2 parts of carbomer, 0.5-1.5 parts of emulsifiers and make up to 100 parts with purified water; The Chinese medicine extract is prepared from the following raw materials in parts by weight: 8-10 parts of sophora flavescens, 6-8 parts of phellodendron amurense, 2-4 parts of cnidium monnieri, 4-6 parts of salvia miltiorrhiza, 4-6 parts of safflower, 4-8 parts of ligusticum chuanxiong, 1-2 parts of asarum and 6-9 parts of dragon's blood.

2. The biological antibacterial gel for balancing the gynecological microecological flora structure according to claim 1, characterized in that: The invention is made of the following raw materials in parts by weight: 0.1 parts of bioactive peptides, 0.05 parts of saponins, 2 parts of laurocapram, 15 parts of Chinese herbal extracts, 0.5 parts of sodium hyaluronate, 0.1 parts of plant essential oils, 1 part of polyethylene glycol, 0.8 parts of lactic acid, 1 part of carboxymethyl cellulose, 1 part of glycerol, 1 part of carbomer, 0.5 parts of emulsifier and make up to 100 parts with purified water; The Chinese medicine extract is prepared from the following raw materials in parts by weight: 8 parts of sophora flavescens, 6 parts of phellodendron amurense, 2 parts of cnidium monnieri, 4 parts of salvia miltiorrhiza, 4 parts of safflower, 4 parts of ligusticum chuanxiong, 1 part of asarum and 6 parts of dragon's blood.

3. The biological antibacterial gel for balancing the gynecological microecological flora structure according to claim 1, characterized in that: The invention is made of the following raw materials in parts by weight: 0.2 parts of bioactive peptides, 0.1 parts of saponin, 3 parts of laurocapram, 18 parts of Chinese herbal extracts, 1 part of sodium hyaluronate, 0.2 parts of plant essential oils, 2 parts of polyethylene glycol, 1.2 parts of lactic acid, 1.5 parts of carboxymethyl cellulose, 1.25 parts of glycerin, 1.5 parts of carbomer, 1 part of emulsifier and make up to 100 parts with purified water; The Chinese medicine extract is prepared from the following raw materials in parts by weight: 9 parts of sophora flavescens, 7 parts of phellodendron amurense, 3 parts of cnidium monnieri, 5 parts of salvia miltiorrhiza, 5 parts of safflower, 6 parts of ligusticum chuanxiong, 1.5 parts of asarum and 8 parts of dragon's blood.

4. The biological antibacterial gel for balancing the gynecological microecological flora structure according to claim 1, characterized in that: The invention is made of the following raw materials in parts by weight: 0.3 parts of bioactive peptides, 0.2 parts of saponin, 4 parts of laurocapram, 20 parts of Chinese herbal extracts, 1.5 parts of sodium hyaluronate, 0.25 parts of plant essential oils, 3 parts of polyethylene glycol, 1.2 parts of lactic acid, 1.5 parts of carboxymethyl cellulose, 1 part of glycerin, 1.5 parts of carbomer, 1 part of emulsifier and make up to 100 parts with purified water; The Chinese medicine extract is prepared from the following raw materials in parts by weight: 10 parts of sophora flavescens, 8 parts of phellodendron amurense, 4 parts of cnidium monnieri, 6 parts of salvia miltiorrhiza, 6 parts of safflower, 8 parts of ligusticum chuanxiong, 2 parts of asarum and 9 parts of dragon's blood.

5. The biological antibacterial gel for balancing the gynecological microecological flora structure according to claim 1, characterized in that: The Ligusticum chuanxiong has the effects of analgesia, anti-inflammatory and improving the ability to tolerate hypoxia; the Asarum has the effects of analgesia, anti-inflammatory, inhibition of pathogenic microorganisms and anti-allergic reactions; and the Sanguisorba officinalis has the effects of anti-thrombosis and improving blood rheology.

6. The biological antibacterial gel for balancing the gynecological microecological flora structure according to claim 1, characterized in that: The laurocapram is odorless, tasteless, and has the function of promoting drug absorption.

7. The biological antibacterial gel for balancing the gynecological microecological flora structure according to claim 1, characterized in that: The preparation process of the biological antibacterial gel comprises the following steps: Step 1: preparing the first mixed solution: adding the Chinese herbal medicine extract, bioactive peptides, saponin and laurocapram to purified water, mixing and filtering to obtain the first mixed solution; Step 2: preparing the second mixed solution: mixing sodium hyaluronate, plant essential oil, polyethylene glycol, lactic acid and carboxymethyl cellulose and filtering to obtain a second filtrate; Step 3: Preparation of biological antibacterial gel: Glycerin, carbomer, emulsifier, the first mixed solution and the second mixed solution are fully mixed and stirred evenly, and then purified water is added to a sufficient amount to obtain a gel.

8. The biological antibacterial gel for balancing the gynecological microecological flora structure according to claim 7, characterized in that: In the step 3, a pH value test is performed during the preparation of the gel, and a pH regulator is gradually added so that the test value is between 4.5 and 7.0.

Images