Ink-jet printing ink containing Chinese herbal medicine components and having uterus warming effect

Abstract

The invention relates to the technical field of transdermal drug delivery, and discloses an ink-jet printing ink containing Chinese herbal medicine components with a uterus warming effect, and the ink-jet printing ink comprises the following components: 10-20% of Chinese herbal medicine powder; 5-15% of a lignin dispersant; 10-15% of natural resin; 5-10% of a viscosity modifier; 0.5 to 2% of a surfactant; 2-5% of a humectant; 0.5-2% of an antiseptic bactericide; and water: the balance. The ink-jet printing ink containing the Chinese herbal medicine components with the uterus warming effect retains the effective components of Chinese herbal medicine for warming yang and uterus and the specific printing precision and fastness performance of digital printing, the raw materials are natural and non-toxic, and the ink is suitable for printing of various uterus-warming and yang-warming treatment and health care textiles in contact with skin.

Description

Technical Field

[0001] The present invention relates to the technical field of transdermal drug delivery, and in particular to an inkjet printing ink containing Chinese herbal medicine components with the effect of warming the uterus. Background Art

[0002] Inkjet printing is mainly based on inkjet printing technology. The printing pattern is designed by a RIP software system, and special multi-channel printing inks are precisely ejected onto the textile material through a nozzle at the same time to form fine patterns and characters in a dot matrix form. It is a non-contact inkjet printing method.

[0003] The transdermal drug delivery system is a new technology for external medicines and health products in the field of "external treatment of traditional Chinese medicine" for treatment and health care. It administers drugs on the skin surface, and the drugs enter the human circulation through ways such as pore dilation and skin penetration to produce systemic or local therapeutic effects at a constant speed through each layer of the skin, belonging to a non-invasive drug delivery technology. Its advantages are as follows: the drug absorption is not affected by complex factors such as the pH in the digestive tract, food, and the intestinal transit time of the drug; it avoids the unnecessary metabolism of drugs in organs such as the stomach, intestines, liver, and kidneys; it can continuously control the drug delivery speed; the administration site is on the body surface, and it is convenient to interrupt the administration, and the compliance can be improved without pain. It is a treatment method without side effects, safe, and effective. Using this principle, digital printing of Chinese herbal medicines can be applied to the field of transdermal drug delivery in medicine. It is a drug delivery method that can accurately spray Chinese herbal medicines on textile fabrics or ready-to-wear clothes or directly spray them on the skin surface. Especially for parts of the skin that are thinner or acupoints, this drug delivery method can directly penetrate into the subcutaneous tissue through the corneal layer of the skin and the accessory structures of the skin such as the openings of hair follicles and sweat gland ducts, enter the capillaries, and be distributed throughout the body through the systemic circulation. This digital printing drug delivery route has the advantages of accuracy, convenience, safety, breathability, and long-lasting drug efficacy.

[0004] The existing digital printing of Chinese herbal medicines is mainly flat screen printing, which has problems such as inaccurate acupoint drug delivery, poor breathability, and easy skin allergies. Summary of the Invention

[0005] The technical problem to be solved by the present invention is the technical problem proposed in the above background art, and provides an inkjet printing ink containing Chinese herbal medicine components with the effect of warming the uterus.

[0006] The technical solution adopted by the present invention to solve its technical problems is:

[0007] The inkjet printing ink contains the following components:

[0008] Chinese herbal medicine powder: 10 - 20%;

[0009] Lignin dispersant: 5 - 15%;

[0010] Natural resin: 10 - 15%;

[0011] Viscosity regulator: 5 - 10%;

[0012] Surfactant: 0.5 - 2%;

[0013] Humectant: 2 - 5%;

[0014] Antiseptic and fungicide: 0.5 - 2%;

[0015] Water: the remaining parts.

[0016] Preferably, the main components of the Chinese herbal medicine powder are: 13% ginger, 10% asarum, 18% processed aconite root, 27% Corydalis yanhusuo, 25% Cyathula officinalis, and 7% wormwood powder.

[0017] Preferably, the natural resin includes vegetable gum and animal glue;

[0018] The vegetable gum is one or more of gum arabic, rosin, myrica bark extract, glutinous rice glue, and latex tree gum;

[0019] The animal glue is one or more of bone glue, casein glue, blood albumin glue, color glue, and shellac.

[0020] Preferably, the viscosity regulator is one or more of guar gum, hydroxyethyl cellulose, carboxymethyl cellulose, and water-soluble alginic acid.

[0021] Preferably, the surfactant is one or more of glycerol monostearate, triglyceride, lecithin, and alkyl polyglycoside.

[0022] Preferably, the humectant is one or more of hyaluronic acid, glycerol, xylitol, erythritol, sorbitol, and mannitol.

[0023] Preferably, the antiseptic and fungicide is one or more of tea polyphenols, allicin, chitosan, and propolis.

[0024] Preferably, the lignin dispersant is sodium lignosulfonate.

[0025] Advantages of the present invention:

[0026] The inkjet printing ink containing Chinese herbal medicine components with the function of warming the uterus provided by the present invention not only retains the effective components of the Chinese herbal medicine for warming the sun and uterus and the printing accuracy and fastness performance unique to digital printing, but also the raw materials are natural, non-toxic, and applicable to the printing of various textiles for warming the uterus and sun treatment and health care that come into contact with the skin. Detailed implementation manners

[0027] The following will clearly and completely describe the concept and technical effects generated by the present invention in combination with the embodiments to fully understand the purpose, features, and effects of the present invention.

[0028] This application designs an inkjet printing ink containing Chinese herbal medicine ingredients with the function of warming the uterus. The inkjet printing ink contains the following ingredients:

[0029] Chinese herbal medicine powder: 10 - 20%;

[0030] Lignin dispersant: 5 - 15%;

[0031] Natural resin: 10 - 15%;

[0032] Viscosity regulator: 5 - 10%;

[0033] Surfactant: 0.5 - 2%;

[0034] Humectant: 2 - 5%;

[0035] Antiseptic and fungicide: 0.5 - 2%;

[0036] Water: the remaining parts.

[0037] The main components of the Chinese herbal medicine powder are: 13% ginger, 10% asarum, 18% processed aconite root, 27% Corydalis yanhusuo, 25% Cyathula officinalis, 7% wormwood powder. The main effects of the Chinese herbal medicine powder are to strengthen primordial qi and consolidate the constitution, promote blood circulation and remove blood stasis, dispel dampness and cold, warm the uterus and relieve pain, and promote and protect menstrual hygiene and health.

[0038] Natural resin includes vegetable gum and animal glue;

[0039] The vegetable gum is one or more of gum arabic, rosin, myrica bark extract, glutinous rice glue, and latex tree gum;

[0040] The animal glue is one or more of bone glue, casein glue, blood albumin glue, color glue, and shellac.

[0041] Both vegetable gum and animal glue are taken from nature, and the products made from them have good compatibility with the skin and can reduce skin allergies during the process of warming the uterus.

[0042] The viscosity regulator is one or more of guar gum, hydroxyethyl cellulose, carboxymethyl cellulose, and water-soluble alginic acid.

[0043] The surfactant is one or more of glycerol monostearate, triglyceride, lecithin, and alkyl polyglycoside.

[0044] The humectant is one or more of hyaluronic acid, glycerol, xylitol, erythritol, sorbitol, and mannitol.

[0045] The antiseptic and fungicide is one or more of tea polyphenols, allicin, chitosan, and propolis.

[0046] The lignin dispersant is sodium lignosulfonate.

[0047] Citric acid is used in the inkjet printing ink, making its working solution weakly acidic with a pH value of 5 - 6.

[0048] The preparation process of the inkjet printing ink is as follows:

[0049] S1: Select one or more of the above-mentioned Chinese herbal medicine raw materials, stir and combine them evenly, and then add 2% of mature vinegar and stir and mix to pre-adjust into a paste.

[0050] S2: Add water, lignin dispersant and preservative and fungicide to the paste according to the formula requirements to make an aqueous suspension of Chinese herbal medicine slurry, and use a sand mill for grinding. The particle size of the Chinese herbal medicine powder after grinding is 500 - 2000 nm, and the slurry is made uniform and stable.

[0051] S3: According to needs, mix one or more of the above components together and process them into a liquid composition through the following processes.

[0052] Among them, the experimental data and final effects of the inkjet printing ink made from Chinese herbal medicines with different concentration contents are shown in the following table:

[0053] Appendix Table 1

[0054] As can be seen from the above table: The inkjet printing ink designed in this application retains the effective components of the Chinese herbal medicine for warming the sun and warming the uterus, as well as the printing accuracy and fastness performance unique to digital printing.

[0055] At present, there are different nozzles and printing schemes for mainstream piezoelectric inkjet printers. The main differences in nozzles lie in the ink droplet size, ink viscosity and resolution. In view of the parameter differences of different mainstream nozzles, in order to ensure smooth and continuous production during production and achieve the effect of warming the uterus, combined with the final effects reflected in the above experimental data for actual production, the following implementation cases are specially selected to further describe the present invention:

[0056] Example 1

[0057] For the Epson nozzle series: low viscosity (ink viscosity is 3 - 4 mPa·s), small ink droplets (3.5 - 5 pl), high resolution (600 * 600 dpi), use the following formula to ensure the smooth progress of the process (the final effect of this formula refers to the content in the 12th row of Appendix Table 1):

[0058] Chinese herbal medicine powder: 10%;

[0059] Sodium lignosulfonate: 5%;

[0060] Arabic gum: 5%;

[0061] Rosin: 5%;

[0062] Guar gum: 1%;

[0063] Monoester glycerol: 0.5%;

[0064] Triglyceride glycerol: 0.5%;

[0065] Glycerol: 2%;

[0066] Allicin: 1%;

[0067] The rest is water.

[0068] First, grind the Chinese herbal medicine powder into microparticles with a diameter of about 500 - 2000 nanometers, make it into a slurry, then add rosin and grind it again to make the rosin have the same particle size distribution, and then mix it with the above other components in proportion and filter it at about 0.5 micron level to complete the preparation.

[0069] Example 2

[0070] For the Starlight nozzle series: high viscosity (ink viscosity is 10 - 12 mPa·s), large ink droplets (10 - 25 pl), low resolution (400 * 400 dpi), use the following formula to ensure the smooth progress of the process (the final effect of this formula refers to the content in the 11th row of Table 1 in the appendix):

[0071] Chinese herbal medicine powder: 20%;

[0072] Sodium lignosulfonate: 10%;

[0073] Glutinous rice glue: 5%;

[0074] Myrica bark extract: 7%;

[0075] Hydroxymethyl cellulose: 5%;

[0076] Monoester glycerol: 0.5%;

[0077] Alkyl polyglycoside: 1%;

[0078] Xylitol: 1%;

[0079] Erythritol: 1%;

[0080] Chitosan: 1%;

[0081] The rest is water.

[0082] First, grind the Chinese herbal medicine powder into microparticles with a diameter of about 500 - 2000 nanometers, make it into a slurry, and then mix it with the above other components in proportion and filter it at about 0.5 micron level to complete the preparation.

[0083] Example 3

[0084] For Kyocera printhead series: medium viscosity (ink viscosity is 6 - 8 mPa·s), small ink droplets (7 - 10 pl), high resolution (600 * 600 dpi), use the following formula to ensure the smooth progress of the process (the final effect of this formula refers to the content in the 5th row of Table 1 in the attached table):

[0085] Chinese herbal medicine powder: 14%;

[0086] Sodium lignosulfonate: 7%;

[0087] Glutinous rice glue: 5%;

[0088] Gum acacia: 8%;

[0089] Water-soluble sodium alginate: 1%;

[0090] Triglyceride: 0.5%;

[0091] Alkyl polyglucoside: 0.5%;

[0092] Hyaluronic acid: 1%;

[0093] Erythritol: 1%;

[0094] Chitosan: 0.5%;

[0095] Tea polyphenols: 1%;

[0096] The rest is water.

[0097] First, grind the Chinese herbal medicine powder into fine particles with a diameter of about 500 - 2000 nanometers, make it into a slurry, then add gum acacia and grind it again to make the gum acacia have the same particle size distribution, and then mix it with the above other components evenly and filter it through about 0.5 - micron level to complete the preparation.

[0098] Example 4

[0099] For Ricoh printhead series: high viscosity (ink viscosity is 10 - 12 mPa·s), small ink droplets (7 - 10 pl), high resolution (600 * 600 dpi), use the following formula to ensure the smooth progress of the process (the final effect of this formula refers to the content in the 13th row of Table 1 in the attached table):

[0100] Chinese herbal medicine slurry: 15%;

[0101] Sodium lignosulfonate: 7.5%;

[0102] Arabic gum: 5%;

[0103] Gum acacia: 7%;

[0104] Guar gum: 0.5%;

[0105] Hydroxypropyl methylcellulose: 5%;

[0106] Monoester of glycerol: 0.5%;

[0107] Alkyl polyglycoside: 1%;

[0108] Xylitol: 1%;

[0109] Erythritol: 1%;

[0110] Chitosan: 1%;

[0111] The balance is water.

[0112] First, the Chinese herbal medicine powder is ground into microparticles with a diameter of about 500 - 2000 nanometers and made into a slurry. Then, gum arabic and gum tragacanth are added for secondary grinding to make them also have the same particle size distribution. Then, it is mixed evenly with the above other components and filtered through a filter of about 0.5 micron level to complete the preparation.

[0113] The above are only the preferred embodiments of the present invention, and it does not thereby limit the protection scope of the present invention. For those skilled in the art, the present invention can have various changes and modifications. Any changes, modifications, substitutions, integrations, and parameter changes made to these embodiments through conventional substitutions or capable of achieving the same functions without departing from the principle and spirit of the present invention fall within the protection scope of the present invention.

Claims

1. An inkjet printing ink containing Chinese herbal medicine components with the function of warming the uterus, characterized in that: The inkjet printing ink contains the following components: Chinese herbal medicine powder: 10 - 20%; Lignin dispersant: 5 - 15%; Natural resin: 10 - 15%; Viscosity regulator: 5 - 10%; Surfactant: 0.5 - 2%; Humectant: 2 - 5%; Antiseptic and fungicide: 0.5 - 2%; Water: the remaining parts.

2. The inkjet printing ink containing Chinese herbal medicine ingredients with the function of warming the uterus according to claim 1, characterized in that : The main components of the Chinese herbal medicine powder are: ginger 13%, asarum 10%, processed aconite root 18%, Corydalis yanhusuo 27%, Cyathula officinalis 25%, wormwood powder 7%.

3. An inkjet printing ink containing a Chinese herbal medicine component with a uterine-warming effect according to claim 1, characterized in that : The natural resin includes vegetable gum and animal glue; The vegetable gum is one or more of gum arabic, rosin, myrica bark tannin extract, glutinous rice glue, and latex tree gum; The animal glue is one or more of bone glue, casein glue, blood albumin glue, color glue, and shellac.

4. An inkjet printing ink containing Chinese herbal medicine ingredients with the function of warming the uterus according to claim 1, characterized in that : The viscosity regulator is one or more of guar gum, hydroxyethyl cellulose, carboxymethyl cellulose, and water-soluble alginic acid.

5. An inkjet printing ink containing a Chinese herbal medicine component with a uterus-warming effect according to claim 1, characterized in that : The surfactant is one or more of monoglyceride, triglyceride, lecithin, and alkyl polyglycoside.

6. The inkjet printing ink containing Chinese herbal medicine components with the function of warming the uterus according to claim 1, wherein : The humectant is one or more of hyaluronic acid, glycerol, xylitol, erythritol, sorbitol, and mannitol.

7. An inkjet printing ink containing Chinese herbal medicine ingredients with the function of warming the uterus according to claim 1, characterized in that : The antiseptic and fungicide is one or more of tea polyphenols, allicin, chitosan, and propolis.

8. An inkjet printing ink containing Chinese herbal medicine ingredients with the function of warming the uterus according to claim 1, characterized in that : The lignin dispersant is sodium lignosulfonate.

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