Composition with eczema repairing effect as well as preparation method and application thereof

Abstract

The invention relates to the technical field of skin care products, and discloses a composition with an eczema repairing effect and a preparation method and application thereof. The composition with the eczema repairing effect contains active ingredients including an oat extract, carboxymethyl chitosan and ceramide, and the oat extract is one or a combination of multiple extracts of oat kernel oil, oat colloidal powder, oat glucan, oat extract, oat kernel fine powder and the like. The ceramide is a mixture of one or more of ceramide NP, ceramide EOP, ceramide AS, ceramide AP, ceramide NS and ceramide NG, and the obtained composition has a remarkable relieving and anti-inflammatory effect, can effectively relieve itching and red and swollen symptoms caused by eczema, also has the effects of repairing a barrier, moisturizing and nourishing, prevents eczema recurrence, and has a good application prospect. The composition is mild and safe in formula, is suitable for sensitive skin and eczema patients, and becomes a product specially designed for eczema skin.

Description

Technical Field

[0001] The present invention relates to the technical field of skin care products, and in particular to a composition capable of repairing eczema, a preparation method thereof and an application thereof. Background Art

[0002] Eczema is a common inflammatory skin disease with a complex pathogenesis. It not only impairs the skin's barrier function, leading to increased transepidermal water loss and decreased moisturizing capacity, but also triggers an abnormal immune response, resulting in symptoms such as erythema, itching, and exudation. Currently, commercially available products for the treatment of eczema have numerous drawbacks.

[0003] Currently, there are obvious limitations in the treatment methods and care products for eczema. In terms of treatment, many conventional treatment drugs contain glucocorticoids. Although they can control symptoms in the short term, long-term use can produce serious side effects such as thinning of the skin, pigmentation, and capillary dilation. At the same time, most products for treating eczema can only temporarily relieve symptoms, such as reducing itching and redness, and cannot fundamentally repair the damaged skin barrier. This makes eczema very prone to recurrence, causing great distress to patients. In terms of care products, most existing moisturizing skin care products and repair products lack targeted formula design, making it difficult to simultaneously meet the needs of soothing inflammation, repairing damaged skin barriers, and preventing recurrence.

[0004] For people with sensitive skin, existing treatments are often highly irritating. Not only do they fail to soothe and repair the skin, but they can actually exacerbate allergic reactions and worsen the condition. They can even contain irritating ingredients, causing secondary damage to the skin of people with sensitive skin and eczema, leading to repeated exacerbations. Therefore, developing a product that can effectively relieve eczema symptoms, repair damaged skin barriers, prevent recurrences, and is gentle, safe, and suitable for sensitive skin and eczema patients has become a key issue in this field. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to provide a composition with the function of repairing eczema and its preparation method, which can effectively relieve the itching and redness and swelling symptoms caused by eczema, has the effect of moisturizing and nourishing, repairing damaged skin, and effectively preventing the recurrence of eczema.

[0006] The technical problem to be solved by the present invention is also to provide an application of a composition with the effect of repairing eczema, which can be used as an active ingredient in skin care products and is suitable for patients with sensitive skin and eczema.

[0007] In order to solve the above technical problems, the first aspect of the present invention provides a composition with the function of repairing eczema, which comprises, by weight percentage: 0.01-30% oat extract, 0.01-15% carboxymethyl deacetylated chitosan, 0.01-5% ceramide, 0.1-3% pH regulator, 0.05-5% low HLB emulsifier, 0.01-0.3% preservative, 0.5-20% conditioner, and the balance water.

[0008] As an improvement of the above solution, the weight ratio of the oat extract, carboxymethyl chitosan and ceramide is (5-9): (2-5):1.

[0009] As an improvement of the above solution, the ceramide is a ceramide nanomaterial formed by PLGA loaded with ceramide, and the average particle size of the ceramide nanomaterial is 70nm-180nm.

[0010] As an improvement of the above solution, the average molecular weight of the PLGA is 20kDa-40kDa; the ratio of LA segments to GA segments in the PLGA is (1.5-2.7):1.

[0011] As an improvement to the above solution, the method for preparing the ceramide nanomaterial includes:

[0012] (1) PLGA, ceramide, and an organic solvent are mixed to form a mixed solution, which is then slowly dropped into a PVA aqueous solution and sheared at high speed to form an emulsion;

[0013] (2) removing the organic solvent, collecting the precipitate by centrifugation, washing, and drying;

[0014] The volume ratio of PLGA to ceramide is (5-10):1, and the mass concentration of PLGA in the mixed solution is 18 mg / mL-28 mg / mL;

[0015] The rotation speed during the high-speed shearing is 12000 rpm-16000 rpm.

[0016] As an improvement to the above solution, the β-glucan content in the oat extract is ≥85%, and the molecular weight distribution PDI is ≤0.2;

[0017] The carboxymethyl chitosan has a carboxymethyl substitution degree of 0.5-0.8 and an average molecular weight of 50 kDa-200 kDa;

[0018] The ceramide is a mixture of one or more of ceramide NP, ceramide EOP, ceramide AS, ceramide AP, ceramide NS, and ceramide NG.

[0019] As an improvement of the above solution, the HLB value of the low HLB emulsifier is 4-7, and the low HLB emulsifier is selected from one or more of lecithin, cetearyl alcohol, glyceryl stearate, polyglyceryl-3 diisostearate, sucrose stearate, and Span series.

[0020] As an improvement of the above solution, the preservative is selected from one or more of phenoxyethanol, caprylyl glycol, caprylhydroxamic acid, 1,2-hexanediol, and 1,2-pentanediol;

[0021] The conditioning agent is selected from one or more of glycerol, 1,2-pentanediol, sphingosine, butylene glycol, 1,3-propylene glycol, polypropylene glycol, and urea.

[0022] The second aspect of the present invention further provides a method for preparing the composition having the effect of repairing eczema, comprising:

[0023] Dissolve carboxymethyl chitosan and oat extract in deionized water, add pH regulator, preservative, and conditioner, heat to 40-45°C to form an aqueous phase, and then cool to room temperature;

[0024] Mix ceramide with a low HLB emulsifier, heat to 60-70°C to form a homogeneous oil phase, and then cool to room temperature;

[0025] Mix the oil phase and the water phase and disperse them homogeneously to obtain the product.

[0026] The third aspect of the present invention also provides a use of the composition having the function of repairing eczema in skin care products.

[0027] The implementation of the present invention has the following beneficial effects:

[0028] In this application, oat extract, carboxymethyl chitosan and ceramide act synergistically as the main active ingredients of the composition, have significant soothing and anti-inflammatory effects, can effectively relieve the itching and redness and swelling symptoms caused by eczema, and also have the effects of repairing the barrier, moisturizing and nourishing, can effectively repair damaged skin, and prevent the recurrence of eczema. The formula of this composition is mild and safe, suitable for patients with sensitive skin and eczema, becoming a product designed specifically for eczema skin, with broad application prospects. DETAILED DESCRIPTION

[0029] In order to make the objectives, technical solutions and advantages of the present invention more clear, the present invention will be further described in detail with reference to specific embodiments below.

[0030] To solve the above problems, the first aspect of the present invention provides a composition with the function of repairing eczema, which comprises, by weight percentage: 0.01-30% oat extract, 0.01-15% carboxymethyl deacetylated chitosan, 0.01-5% ceramide, 0.1-3% pH regulator, 0.05-5% low HLB emulsifier, 0.01-0.3% preservative, 0.5-20% conditioner, and the balance water.

[0031] In this application, oat extract, carboxymethyl chitosan and ceramide act synergistically as the main active ingredients of the composition, have significant soothing and anti-inflammatory effects, can effectively relieve the itching and redness and swelling symptoms caused by eczema, and also have the effects of repairing the barrier, moisturizing and nourishing, can effectively repair damaged skin, and prevent the recurrence of eczema. The formula of this composition is gentle and safe, suitable for patients with sensitive skin and eczema, and is a product designed specifically for eczema skin.

[0032] Specifically, oat extract (Avena sativa L) contains active substances such as β-glucan and polyphenols, which can inhibit the release of inflammatory factors, reduce the redness and itching caused by allergic reactions, reduce the irritation and discomfort caused by eczema, and effectively restore the damaged skin barrier function by promoting epidermal differentiation, increasing lipid synthesis, and reducing transepidermal water loss. Carboxymethyl chitosan can cooperate with oat extract to further inhibit the release of inflammatory factors, reduce the redness and itching caused by eczema, promote the generation of epidermal keratinocytes, and accelerate the recovery of damaged skin barrier. At the same time, the cationic properties contained in carboxymethyl chitosan can adsorb and inhibit the proliferation of pathogens, kill common pathogens of eczema, reduce the risk of skin infection, help maintain the stability of the skin microenvironment, reduce the recurrence of inflammation, and it has excellent moisturizing properties. Long-term use can maintain skin moisture balance, relieve the recurrence of eczema induced by dryness, and reduce the skin's hypersensitivity to external stimuli by repairing the barrier and regulating the immune response. Finally, ceramide can work with carboxymethyl chitosan to repair the damaged skin barrier, reduce the invasion of external irritants and allergens, reduce the inflammatory response of eczema, and enhance the skin's ability to retain moisture, keeping the skin hydrated and reducing the vulnerability of the barrier caused by dehydration. In addition, by supplementing exogenous ceramide, the thickness of the epidermal lipid layer can be further repaired, the skin's defense against external stimuli can be enhanced, the colonization of pathogens can be reduced, and it can participate in cell signaling, promote the metabolism of healthy keratinocytes, and reduce the immune disorders caused by chronic inflammation, thereby further inhibiting the recurrence of eczema.

[0033] Preferably, the weight ratio of the oat extract, carboxymethyl chitosan and ceramide is (5-9): (2-5): 1. The inventors have found through a large number of experiments that at this time, ceramide leads the lipid barrier reconstruction and reduces transepidermal water loss, carboxymethyl chitosan locks water through hydrogen bonds to prolong moisturizing time and adsorb irritants, and oat extract can enhance the transdermal absorption efficiency of active ingredients and activate TLR-2 receptors to inhibit the release of inflammatory factors. The three synergistically improve the skin's moisturizing degree and significantly reduce the area of erythema. Moreover, the composition system formed under this ratio has good storage stability, strong antioxidant capacity, and minimal irritation to sensitive skin. If the amount of oat extract is too much and the amount of carboxymethyl chitosan is too little, the network formed by the composition is loose and stratification is prone to occur. If the amount is too much, the cross-linking is too dense, which will inhibit the lamellar structure arrangement of ceramide. However, if the amount of ceramide added is too much, it will compete with carboxymethyl chitosan for adsorption sites, weaken the heavy metal ion scavenging ability, and lead to a weakened effect. Illustratively, the weight ratio of the oat extract, carboxymethyl chitosan and ceramide is 5:2:1, 7:2:1, 9:2:1, 5:3:1, 7:3:1, 9:3:1, 5:5:1, 7:5:1, 9:5:1, but is not limited thereto.

[0034] Preferably, the β-glucan content in the oat extract is ≥85%, which can not only promote the expression of ceramide synthase and inhibit the expression of inflammatory factors, but also reduce the electrostatic repulsion with carboxymethyl deacetylated chitosan, promote the co-penetration of the two in the stratum corneum, and improve the targeted delivery efficiency of active ingredients. At the same time, the molecular weight distribution PDI of the oat extract is controlled to be ≤0.2, which has good compatibility in the system and forms a three-dimensional network structure in the aqueous phase, which can avoid system stratification or precipitation caused by local aggregation. Moreover, the low PDI particles can be evenly distributed on the skin surface, complementing the lamellar lipid structure of ceramide, enhancing the coverage of the sebum membrane defect area, shortening the repair cycle, and reducing the chance of eczema recurrence. Exemplarily, the β-glucan content in the oat extract can be 85%, 87%, 89%, 91%, 93%, 95%, but not limited thereto; the molecular weight distribution PDI of the oat extract can be 0.2, 0.18, 0.15, 0.12, 0.1, but not limited thereto. It can be understood that the oat extract in the composition can specifically be a combination of one or more extracts selected from oat kernel oil, oat colloidal powder, oat glucan, oat extract, oat kernel powder, and the like.

[0035] Preferably, the carboxymethyl chitosan has a carboxymethyl degree of substitution of 0.5-0.8 and an average molecular weight of 50kDa-200kDa. After dissolving in an aqueous phase, it significantly increases the viscosity of the system, adsorbs at the oil / water interface through hydrogen bonding and electrostatic interactions, reduces interfacial tension, promotes the uniform dispersion of oil droplets into nanoparticles, and effectively balances water solubility and bioadhesion, promoting the formation of a uniformly dispersed system. Exemplarily, the carboxymethyl degree of substitution of the carboxymethyl chitosan is 0.5, 0.6, 0.7, or 0.8, but is not limited thereto, and the average molecular weight is 50kDa, 75kDa, 100kDa, 125kDa, 150kDa, 175kDa, or 200kDa, but is not limited thereto.

[0036] Preferably, the ceramide is a fat-soluble component that is poorly soluble in oil and water and easily crystallizes and precipitates. Moreover, the ceramide particle size is large and the dispersion is low, making it difficult to penetrate the skin barrier and reach the stratum corneum. More importantly, the polyphenols and other substances contained in the oat extract easily cause it to oxidize, reducing its activity. Therefore, in the present application, the ceramide is a ceramide nanomaterial formed by PLGA (polylactic acid-co-glycolic acid) loaded with ceramide. PLGA, as a degradable polymer carrier, can encapsulate ceramide to form nanoparticles, and electrostatically bind with carboxymethyl chitosan to further enhance the stability of the system and cell adhesion, avoid crystallization, and combine ceramide with the active ingredients in the oat extract to form flocculent precipitates, thereby improving water dispersibility. At the same time, it can also maintain activity and achieve a sustained-release effect, prolong the repair time, and further reduce the possibility of recurrence of eczema.

[0037] Furthermore, the average particle size of the ceramide nanomaterial is 70nm-180nm, which can penetrate into the stratum corneum through the lipid gaps in the skin, improving its permeability and further enhancing the soothing, anti-inflammatory, moisturizing, and repairing effects of the composition. Exemplary particle sizes are 70nm, 90nm, 110nm, 130nm, 150nm, 170nm, and 180nm, but are not limited thereto.

[0038] Optionally, the average molecular weight of the PLGA is 20kDa-40kDa, and the ratio of LA (lactic acid) segments to GA (glycolic acid) segments in the PLGA is (1.5-2.7):1. The applicant has found through a large number of experiments that at this time, PLGA-ceramide nanoparticles with high encapsulation rate, suitable particle size, and clear sustained-release characteristics can be prepared, which are suitable for eczema repair compositions and meet the needs of people with sensitive skin.

[0039] In some specific and preferred embodiments, the method for preparing the ceramide nanomaterial comprises:

[0040] (1) PLGA, ceramide, and an organic solvent are mixed to form a mixed solution, which is then slowly dropped into a PVA aqueous solution and sheared at high speed to form an emulsion;

[0041] (2) Remove the organic solvent, collect the precipitate by centrifugation, wash and dry it.

[0042] Optionally, the volume ratio of PLGA to ceramide is (5-10):1, and the mass concentration of PLGA in the mixture is 18 mg / mL-28 mg / mL. In this case, a high encapsulation efficiency, an appropriate drug loading amount, and nanoparticle stability can be achieved, and the system is suitable for a sustained-release delivery system of an eczema repair composition. Exemplary organic solvents include dichloromethane, ethyl acetate, and the like.

[0043] Optionally, the rotation speed during high-speed shearing is 12000 rpm-16000 rpm. Shearing the mixture at a rotation speed of 12000 rpm-16000 rpm can form a uniformly dispersed and stable emulsion, and after drying, nanoparticles with a particle size in the range of 70 nm-180 nm are obtained.

[0044] It is understood that the ceramide is a mixture of one or more of ceramide NP, ceramide EOP, ceramide AS, ceramide AP, ceramide NS, and ceramide NG. More preferably, the ceramide is ceramide NP, which can lock in moisture, maintain water-oil balance, promote skin cell repair and regeneration, improve the barrier effect, and more significantly improve eczema symptoms.

[0045] Preferably, the addition of the pH adjuster places the system in a weakly acidic environment, optimizing the solubility of carboxymethyl chitosan and ceramide. More preferably, the pH adjuster controls the pH of the system within the range of 5.5-6.0, which is close to the pH of healthy skin and minimizes skin irritation. Optionally, the pH adjuster is one or both of a citric acid / sodium citrate system and a lactic acid / sodium lactate system.

[0046] Preferably, the HLB value of the low HLB emulsifier is 3-8, and it has high compatibility with ceramides, which can make the system evenly dispersed, form a stable liquid crystal phase, and simulate the lipid arrangement of the skin. Optionally, the low HLB emulsifier is selected from one or more of lecithin, cetearyl alcohol, glyceryl stearate, polyglyceryl-3 diisostearate, sucrose stearate, and the Span series; more preferably, the low HLB emulsifier is polycetyl stearyl alcohol and sucrose stearate, which can stabilize the two phases at the same time, and the formed system has strong stability and low irritation, which is suitable for sensitive skin. Furthermore, the weight ratio of the cetearyl alcohol and sucrose stearate is 1: (1.2-1.8), exemplified by 1:1.2, 1:1.4, 1:1.6, and 1:1.8, but not limited to this.

[0047] Preferably, the preservative is selected from one or more of phenoxyethanol, caprylyl glycol, caprylhydroxamic acid, 1,2-hexanediol, and 1,2-pentanediol; more preferably, the preservative is phenoxyethanol and 1,2-pentanediol, and the weight ratio of phenoxyethanol and 1,2-pentanediol is 1:(0.3-0.7), which can not only prevent the growth of microorganisms in the system, but also cooperate with the emulsifier to promote the stability of the oat extract and avoid polysaccharide degradation.

[0048] Preferably, the conditioning agent is selected from one or more of glycerol, 1,2-pentanediol, sphingosine, butylene glycol, 1,3-propylene glycol, polypropylene glycol, and urea; more preferably, the conditioning agent is glycerol and sphingosine, which can improve the consistency of the system, increase the system's low-temperature and high-temperature stability, and promote the permeability of oat extract, carboxymethyl chitosan, and ceramide in the system, further improving the soothing and anti-inflammatory, moisturizing, and barrier repair effects. In some specific and preferred embodiments, the weight ratio of glycerol to sphingosine is 1: (0.4-0.7), at which point the composition has the best efficacy and minimizes skin irritation.

[0049] Accordingly, the second aspect of the present invention provides a method for preparing the composition having the effect of repairing eczema, comprising:

[0050] (1) dissolving carboxymethyl chitosan and oat extract in deionized water, adding a pH adjuster, a preservative, and a conditioner, heating to 40° C.-45° C. to form an aqueous phase, and then cooling to room temperature;

[0051] (2) Mixing ceramide with a low HLB emulsifier, heating to 60-70°C to form a homogeneous oil phase, and then cooling to room temperature;

[0052] (3) Mix the oil phase and the water phase and disperse them uniformly.

[0053] Correspondingly, the third aspect of the present invention provides a use of the composition having the function of repairing eczema in skin care products.

[0054] Furthermore, the weight of the composition having the effect of repairing eczema in the skin care product accounts for 10-15% of the weight of the cosmetic, and the rest is the basic ingredients for preparing the skin care product. Optionally, the skin care product can be a moisturizing cream, a moisturizing ointment, a talcum powder, a comfrey ointment, or a moisturizing lotion.

[0055] The present invention will be further described below with specific embodiments:

[0056] Example 1

[0057] This embodiment provides a composition having the effect of repairing eczema, which comprises, by weight percentage: 0.01% oat extract, 0.01% carboxymethyl chitosan, 0.01% ceramide NP, 0.1% citric acid / sodium citrate, 0.05% cetearyl alcohol, 0.01% phenoxyethanol, 0.5% glycerol, and the balance water.

[0058] The preparation method of the composition having the effect of repairing eczema comprises:

[0059] (1) Dissolve carboxymethyl chitosan and oat extract in deionized water, add citric acid / sodium citrate, phenoxyethanol, and glycerol, heat to 45°C to form an aqueous phase, and then cool to room temperature;

[0060] (2) Ceramide and cetearyl alcohol were mixed and heated to 65°C to form a homogeneous oil phase, and then cooled to room temperature;

[0061] (3) Mix the oil phase and the water phase and disperse them uniformly.

[0062] Correspondingly, this embodiment also provides a moisturizing cream, in which the weight of the composition having the function of repairing eczema in the moisturizing cream accounts for 15% of the weight of the cosmetic, and the rest are basic ingredients for preparing the moisturizing cream.

[0063] Example 2

[0064] This embodiment provides a composition having the effect of repairing eczema, which is basically the same as Example 1, except that: based on weight percentage, it includes: 30% oat extract, 15% carboxymethyl deacetylated chitosan, 5% ceramide NP, 2% citric acid / sodium citrate, 4% cetearyl alcohol, 0.25% phenoxyethanol, 18% glycerol, and the balance water.

[0065] The product was prepared by the preparation method in Example 1.

[0066] Correspondingly, this embodiment also provides a moisturizing cream, in which the weight of the composition having the function of repairing eczema in the moisturizing cream accounts for 10% of the weight of the cosmetic, and the rest are basic ingredients for preparing the moisturizing cream.

[0067] Example 3

[0068] This embodiment provides a composition having the effect of repairing eczema, which is basically the same as Example 1, except that: based on weight percentage, it includes: 20% oat extract, 9% carboxymethyl deacetylated chitosan, 2.5% ceramide NP, 1.5% citric acid / sodium citrate, 2% cetearyl alcohol, 0.1% phenoxyethanol, 11% glycerol, and the balance water.

[0069] The product was prepared by the preparation method in Example 1.

[0070] Correspondingly, this embodiment also provides a moisturizing cream, in which the weight of the composition having the function of repairing eczema in the moisturizing cream accounts for 13% of the weight of the cosmetic, and the rest are basic ingredients for preparing the moisturizing cream.

[0071] Example 4

[0072] This embodiment provides a composition having the effect of repairing eczema, which is basically the same as that of Example 3, except that:

[0073] The ceramide is a ceramide nanomaterial formed by PLGA loaded with ceramide NP, the average particle size of the ceramide nanomaterial is 70 nm, the average molecular weight of the PLGA is 30 kDa; the ratio of the LA segment to the GA segment in the PLGA is 2:1;

[0074] The preparation method of the ceramide nanomaterial comprises:

[0075] (1) PLGA, ceramide NP, and ethyl acetate are mixed to form a mixed solution, which is then slowly dropped into a PVA aqueous solution and subjected to high-speed shearing to form an emulsion; wherein the volume ratio of the PLGA to ceramide is 7:1, the mass concentration of PLGA in the mixed solution is 20 mg / mL, and the rotation speed during high-speed shearing is 16000 rpm;

[0076] (2) removing the organic solvent, collecting the precipitate by centrifugation, washing, and drying;

[0077] The product was prepared by the preparation method in Example 1.

[0078] Correspondingly, this embodiment also provides a moisturizing cream, in which the weight of the composition having the function of repairing eczema in the moisturizing cream accounts for 13% of the weight of the cosmetic, and the rest are basic ingredients for preparing the moisturizing cream.

[0079] Example 5

[0080] This embodiment provides a composition having the effect of repairing eczema, which is basically the same as that of Example 4, except that:

[0081] The average particle size of the ceramide nanomaterial is 120 nm, and the rotation speed during high-speed shearing is 14,000 rpm.

[0082] The product was prepared by the preparation method in Example 1.

[0083] Correspondingly, this embodiment also provides a moisturizing cream, in which the weight of the composition having the function of repairing eczema in the moisturizing cream accounts for 13% of the weight of the cosmetic, and the rest are basic ingredients for preparing the moisturizing cream.

[0084] Example 6

[0085] This embodiment provides a composition having the effect of repairing eczema, which is basically the same as that of Example 4, except that:

[0086] The average particle size of the ceramide nanomaterial is 180 nm, and the rotation speed during high-speed shearing is 12,000 rpm.

[0087] The product was prepared by the preparation method in Example 1.

[0088] Correspondingly, this embodiment also provides a moisturizing cream, in which the weight of the composition having the function of repairing eczema in the moisturizing cream accounts for 13% of the weight of the cosmetic, and the rest are basic ingredients for preparing the moisturizing cream.

[0089] Example 7

[0090] This embodiment provides a composition having the effect of repairing eczema, which is basically the same as that of Example 5, except that:

[0091] The beta-glucan content in the oat extract is 92%, and the molecular weight distribution PDI is 0.15; the carboxymethyl substitution degree of the carboxymethyl deacetylated chitosan is 0.7, and the average molecular weight is 120 kDa.

[0092] The product was prepared by the preparation method in Example 1.

[0093] Correspondingly, this embodiment also provides a moisturizing cream, in which the weight of the composition having the function of repairing eczema in the moisturizing cream accounts for 13% of the weight of the cosmetic, and the rest are basic ingredients for preparing the moisturizing cream.

[0094] Example 8

[0095] This embodiment provides a composition having the effect of repairing eczema, which is basically the same as that of Example 7, except that:

[0096] The low HLB emulsifier is polycetyl stearyl alcohol and sucrose stearate, and the weight ratio of the cetyl stearyl alcohol to sucrose stearate is 1:1.4.

[0097] The product was prepared by the preparation method in Example 1.

[0098] Correspondingly, this embodiment also provides a moisturizing cream, in which the weight of the composition having the function of repairing eczema in the moisturizing cream accounts for 13% of the weight of the cosmetic, and the rest are basic ingredients for preparing the moisturizing cream.

[0099] Example 9

[0100] This embodiment provides a composition having the effect of repairing eczema, which is basically the same as that of Example 8, except that:

[0101] The preservatives are phenoxyethanol and 1,2-pentanediol, and the weight ratio of phenoxyethanol to 1,2-pentanediol is 1:0.6.

[0102] The product was prepared by the preparation method in Example 1.

[0103] Correspondingly, this embodiment also provides a moisturizing cream, in which the weight of the composition having the function of repairing eczema in the moisturizing cream accounts for 13% of the weight of the cosmetic, and the rest are basic ingredients for preparing the moisturizing cream.

[0104] Example 10

[0105] This embodiment provides a composition having the effect of repairing eczema, which is basically the same as that of Example 9, except that:

[0106] The conditioning agents are glycerol and sphingosine, and the weight ratio of the glycerol to sphingosine is 1:0.5.

[0107] The product was prepared by the preparation method in Example 1.

[0108] Correspondingly, this embodiment also provides a moisturizing cream, in which the weight of the composition having the function of repairing eczema in the moisturizing cream accounts for 13% of the weight of the cosmetic, and the rest are basic ingredients for preparing the moisturizing cream.

[0109] Comparative Example 1

[0110] This comparative example provides a composition with the effect of repairing eczema, which is basically the same as Example 1, except that: by weight percentage, it includes: 20% oat extract, 9% carboxymethyl deacetylated chitosan, 6% ceramide NP, 1.5% citric acid / sodium citrate, 2% cetearyl alcohol, 0.1% phenoxyethanol, 11% glycerol, and the balance water.

[0111] The product was prepared by the preparation method in Example 1.

[0112] Correspondingly, this embodiment also provides a moisturizing cream, in which the weight of the composition having the function of repairing eczema in the moisturizing cream accounts for 13% of the weight of the cosmetic, and the rest are basic ingredients for preparing the moisturizing cream.

[0113] Performance Testing

[0114] 1. Stability test: The compositions having the effect of repairing eczema in the examples and comparative examples were placed in a 40°C environment for 48 hours, and the state of the compositions having the effect of repairing eczema was observed after returning to room temperature. Subsequently, the compositions having the effect of repairing eczema were placed in a -8°C environment for 48 hours, and the state of the compositions having the effect of repairing eczema was observed after returning to room temperature. The test results are shown in Table 1.

[0115] 2. Moisturizing Test: The skin moisture retention of 33 volunteers (3 in each group) was tested using a Corneometer CM 825 (Courage Khazaka, Germany). A 4 cm × 4 cm test area was marked on the flexor side of the left and right forearms of the subjects, and each sample was applied. The application rate was 3 mg / cm 2 , and gently massage until the sample is absorbed. Use a skin moisture meter to measure the skin moisture content before and 6 hours after application. Calculate the skin moisture increase rate according to the following formula. Take the average of the skin moisture increase rates of the volunteers who used each sample to obtain the average skin moisture increase rate of the sample. The calculation formula is as follows:

[0116] Skin moisture content increase rate (%) = (measured value after application minus base value before application) / base value before application * 100%.

[0117] The test results are shown in Table 1.

[0118] Table 1 Test results of high and low temperature stability of the composition with eczema repairing effect and moisturizing property of the moisturizing cream

[0119]

[0120]

[0121] The above results indicate that, in this application, the composition comprising oat extract, carboxymethyl chitosan, and ceramide as the main active ingredients, in combination with other components such as a low-HLB emulsifier, preservative, and conditioner, produces a composition with the ability to repair eczema, exhibiting good high and low temperature stability, and promoting the penetration of the active ingredients, resulting in a moisturizing and nourishing effect. Furthermore, optimizing the weight ratio of oat extract, carboxymethyl chitosan, and ceramide, the structure of ceramide, and the types of low-HLB emulsifier, preservative, and conditioner can further improve skin moisture content.

[0122] 3. Skin Barrier Function Repair Test: 110 subjects with sensitive skin suffering from eczema, 55 men and 55 women, aged between 18 and 50 years, were randomly divided into 11 groups (10 subjects per group). Each group was tested with the corresponding moisturizers obtained in Examples 1 to 10 and Comparative Example 1. Specifically, the moisturizers were applied once daily, morning and evening, after cleaning the sensitive skin area. The first test was conducted after 3 consecutive days of use, and the second test was conducted after 7 consecutive days of use. The judgment criteria are as follows:

[0123] (1) Cure: Eczema subsides, and skin redness, swelling, itching, and skin lesions disappear;

[0124] (2) Significant effect: Eczema subsides by more than 60%, with only slight itching, redness, swelling, and skin lesions;

[0125] (3) Effective: Eczema subsides by 20-60%, and skin itching, redness, swelling, and lesions are slightly alleviated;

[0126] (4) Ineffective: There was no significant change in symptoms such as skin redness, itching, and skin lesions.

[0127] (5) Aggravation: Symptoms such as skin redness, swelling, itching, and skin lesions worsen.

[0128] A follow-up examination was conducted 3 months later to determine whether there was any recurrence during this period. The test results are shown in Table 2.

[0129] Table 2 Eczema treatment effects of the moisturizing creams obtained in the examples and comparative examples

[0130]

[0131]

[0132] The above results demonstrate that the composition, using oat extract, carboxymethyl chitosan, and ceramide as its primary active ingredients, can effectively treat eczema, repair damaged skin, and reduce eczema recurrence. Furthermore, optimizing the weight ratio of oat extract, carboxymethyl chitosan, and ceramide, the structure of ceramide, and the types of low-HLB emulsifiers, preservatives, and conditioning agents can further enhance the efficacy of eczema treatment.

[0133] The above disclosure is only a preferred embodiment of the present invention and certainly cannot be used to limit the scope of the present invention. Therefore, equivalent changes made according to the claims of the present invention are still within the scope of the present invention.

Claims

1. A composition having the effect of repairing eczema, characterized in that: Calculated by weight, the invention comprises: 0.01-30% of oat extract, 0.01-15% of carboxymethyl chitosan, 0.01-5% of ceramide, 0.1-3% of pH regulator, 0.05-5% of low HLB emulsifier, 0.01-0.3% of preservative, 0.5-20% of conditioner, and the balance of water.

2. The composition for repairing eczema according to claim 1, wherein: The weight ratio of the oat extract, carboxymethyl chitosan and ceramide is (5-9): (2-5):

1.

3. The composition for repairing eczema according to claim 1, wherein: The ceramide is a ceramide nanomaterial formed by PLGA loaded with ceramide, and the average particle size of the ceramide nanomaterial is 70nm-180nm.

4. The composition having the effect of repairing eczema according to claim 3, characterized in that: The average molecular weight of the PLGA is 20kDa-40kDa; the ratio of the LA segment to the GA segment in the PLGA is (1.5-2.7):

1.

5. The composition having the effect of repairing eczema according to claim 3 or 4, characterized in that: The preparation method of the ceramide nanomaterial comprises: (1) PLGA, ceramide, and an organic solvent are mixed to form a mixed solution, which is then slowly dropped into a PVA aqueous solution and sheared at high speed to form an emulsion; (2) removing the organic solvent, collecting the precipitate by centrifugation, washing, and drying; The volume ratio of PLGA to ceramide is (5-10):1, and the mass concentration of PLGA in the mixed solution is 18 mg / mL-28 mg / mL; The rotation speed during the high-speed shearing is 12000 rpm-16000 rpm.

6. The composition having the effect of repairing eczema according to claim 1, wherein: The β-glucan content of the oat extract is ≥85%, and the molecular weight distribution PDI is ≤0.2; The carboxymethyl chitosan has a carboxymethyl substitution degree of 0.5-0.8 and an average molecular weight of 50 kDa-200 kDa; The ceramide is a mixture of one or more of ceramide NP, ceramide EOP, ceramide AS, ceramide AP, ceramide NS, and ceramide NG.

7. The composition having the effect of repairing eczema according to claim 1, wherein: The HLB value of the low HLB emulsifier is 4-7, and the low HLB emulsifier is selected from one or more of lecithin, cetearyl alcohol, glyceryl stearate, polyglyceryl-3 diisostearate, sucrose stearate, and a Span series.

8. The composition having the effect of repairing eczema according to claim 1, wherein: The preservative is selected from one or more of phenoxyethanol, caprylyl glycol, caprylhydroxamic acid, 1,2-hexanediol, and 1,2-pentanediol; The conditioning agent is selected from one or more of glycerol, 1,2-pentanediol, sphingosine, butylene glycol, 1,3-propylene glycol, polypropylene glycol, and urea.

9. A method for preparing the composition having the effect of repairing eczema according to any one of claims 1 to 8, characterized in that: include: Dissolve carboxymethyl chitosan and oat extract in deionized water, add pH regulator, preservative, and conditioner, heat to 40-45°C to form an aqueous phase, and then cool to room temperature; Mix ceramide with a low HLB emulsifier, heat to 60-70°C to form a homogeneous oil phase, and then cool to room temperature; Mix the oil phase and the water phase and disperse them homogeneously to obtain the product.

10. Use of the composition having eczema repairing effect according to any one of claims 1 to 8 in skin care products.

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