Acousto-optic stimulation method and device for preventing and conditioning Alzheimer's disease

Abstract

The invention discloses an acousto-optic stimulation method and device for preventing and conditioning Alzheimer's disease, and the method comprises the steps: generating sound with a specific frequency and flash with a specific frequency, and the acousto-optic stimulation device comprises a microcontroller, a motor driver, a power supply, a light regulation and control module, and an audio amplifier; the power supply supplies power to the microcontroller, the motor driver, the light regulation and control module and the audio amplifier; the input end of the motor driver is connected with the microcontroller, and the motor driver is used for performing power amplification on the PWM waves; the output end of the motor driver is connected with the driving audio amplifier or the audio amplifier, and the motor driver is used for driving the audio amplifier to generate sound with specific frequency or driving the light regulation and control module to output flash with specific frequency. The device provided by the invention can conveniently adjust and output light with the frequency of 40Hz or audio with the frequency of 40Hz only by adjusting the duration time of the high level in each period, and realizes and controls the principle and accurate control of an acousto-optic stimulation method with the frequency of 40Hz.

Description

Technical Field

[0001] The present invention belongs to the field of medical equipment for Alzheimer's disease, and specifically relates to an acoustic and optical stimulation method and device for preventing and regulating Alzheimer's disease. Background Art

[0002] Alzheimer's disease (AD), commonly known as senile dementia, is a degenerative central nervous system disease whose progression worsens over time.

[0003] The latest research shows that 40 Hz sound and light stimulation helps stimulate the brain's glymphatic system to accelerate cerebrospinal fluid to "flushed away" pathogenic protein deposits; an early clinical study of the safety and efficacy of 40 Hz sensory stimulation for the treatment of Alzheimer's disease found that this potential therapy was well tolerated, had no serious adverse reactions, and produced some significant neurological and behavioral benefits in a small group of participants.

[0004] Currently, the existing prevention and treatment equipment for Alzheimer's disease is a dedicated AC device in medical institutions, which requires expensive fees and appointment time. Ordinary patients do not have portable home devices that can be used at any time to prevent and treat Alzheimer's disease. Summary of the Invention

[0005] In response to the above situation, the embodiments of the present application provide an acoustic and optical stimulation method and device for preventing and treating Alzheimer's disease.

[0006] In the first aspect, an embodiment of the present application provides an acoustic and optical stimulation device for preventing and treating Alzheimer's disease, which is used to generate sound of a specific frequency. The device includes a microcontroller, a power supply, a voice module, a speaker, and a storage module. The power supply supplies power to the microcontroller, voice module, speaker, and storage module. The storage module is used to store audio with a frequency of 40 Hz. The microcontroller is used to control the voice module to play the audio with a frequency of 40 Hz stored in the storage module and play it through the speaker.

[0007] In the second aspect, an embodiment of the present application provides an acoustic and light stimulation device for preventing and treating Alzheimer's disease, which is used to generate flashes of a specific frequency. The device includes a microcontroller, a power supply, a light control module and an LED lamp. The power supply supplies power to the microcontroller, the light control module and the LED lamp. The microcontroller is used to generate a PWM wave with a certain frequency and duty cycle. The light control module controls the flashing frequency of the LED lamp according to the PWM wave generated by the microcontroller.

[0008] On the third aspect, an embodiment of the present application provides an acoustic and light stimulation device for preventing and treating Alzheimer's disease, wherein the acoustic and light stimulation device is used to generate flashes of a specific frequency. The device is used to generate flashes of a specific frequency. The device includes a microcontroller, a power supply, a motor drive module, and an LED lamp. The power supply supplies power to the microcontroller, the light control module, and the LED lamp. The microcontroller is used to control the motor drive module to generate a PWM wave of a certain frequency and duty cycle. The motor drive module controls the flashing frequency of the LED lamp according to the generated PWM wave.

[0009] In a fourth aspect, embodiments of the present application provide an acoustic and optical stimulation device for preventing and treating Alzheimer's disease, which is used to generate sounds and flashes of a specific frequency. The acoustic and optical stimulation device includes a microcontroller, a motor driver, a power supply, a light control module, and an audio amplifier. The power supply is used to power the microcontroller, motor driver, lighting control module and audio amplifier; The input end of the motor driver is connected to the microcontroller for power amplification of the PWM wave; The output end of the motor driver is connected to a driving audio amplifier or an audio amplifier, and is used to drive the audio amplifier to generate a sound of a specific frequency or drive the light control module to output a flash of a specific frequency.

[0010] In some embodiments, the microcontroller is an embedded circuit composed of an MCU as a core, which is internally provided with a timer and a PWM circuit. By setting the interrupt interval of the timer, the PWM circuit is controlled to output a PWM wave.

[0011] In some embodiments, the microcontroller has a first timer and a second timer, the first timer is integrated with a first PWM generating circuit, and the second timer is integrated with a second PWM generating circuit. The first timer interrupt in the microcontroller is started according to the program setting to output the first PWM wave, and the second timer interrupt in the microcontroller is started according to the program setting to output the second PWM wave.

[0012] In some embodiments, after a first timer interrupt is received in the microcontroller, the microcontroller outputs a first PWM wave to the motor driver, which amplifies the power of the first PWM wave and drives the audio amplifier to generate sound of a specific frequency. When the second timer interrupt in the microcontroller arrives, the second PWM wave is output to the motor driver, and the motor driver amplifies the power of the second PWM wave to drive the light control module to generate a flash of a specific frequency.

[0013] In some embodiments, audio with a frequency of 40 Hz is obtained by adjusting the duty cycle of the PWM wave.

[0014] In some embodiments, a flash light with a frequency of 40 Hz is obtained by adjusting the duty cycle of the PWM wave.

[0015] In some embodiments, a 40 Hz flash or a 40 Hz audio frequency is obtained by adjusting the duty cycle of the PWM wave.

[0016] In a fifth aspect, embodiments of the present application provide a method for preventing and treating Alzheimer's disease through sound and light stimulation, the method comprising: Configure the frequency and duty cycle of the PWM wave to be output; Controlling the first timer or the second timer in the microprocessor through a program; When the first timer interrupt in the microcontroller arrives, the first PWM wave is output to the motor driver, and the motor driver amplifies the power of the first PWM wave and drives the audio amplifier to generate sound of a specific frequency; When the second timer interrupt in the microcontroller arrives, it outputs the second PWM wave to the motor driver, which amplifies the power of the second PWM wave and drives the light control module to generate a flash of a specific frequency.

[0017] At least one of the above technical solutions adopted in the embodiments of the present application can achieve the following beneficial effects: The device provided by the present invention can conveniently adjust the output of 40Hz frequency light or 40Hz frequency audio by simply adjusting the high level duration within each cycle, realize and control the principle and precise control of the 40Hz frequency sound and light stimulation method, and generate sound of a specific frequency by playing a recorded audio amplifier, so that the elderly can easily obtain 40Hz sound stimulation to promote brain Y nerve oscillation, relieve anxiety, depression and irritability of Alzheimer's patients, thereby inhibiting and reducing the aggravation of Alzheimer's disease, and is used for the prevention and conditioning of Alzheimer's disease.

[0018] The present invention has the advantages of simple structure and portability, and is more convenient to use than large equipment in traditional hospitals. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The drawings described herein are used to provide a further understanding of the present application and constitute a part of the present application. The illustrative embodiments of the present application and their descriptions are used to explain the present application and do not constitute an improper limitation on the present application. In the drawings: Figure 1 This is a hardware structure model diagram of the device for preventing and regulating sound and light stimulation of the present invention: Figure 2 This is a block diagram of the hardware configuration of the 40Hz sound stimulation method; Figure 3 This is a block diagram of the hardware configuration of the 40Hz flash stimulation method; Figure 4 This is a block diagram of the 40Hz flash control PWM principle. DETAILED DESCRIPTION

[0020] To make the purpose, technical solutions, and advantages of this application more clear, the technical solutions of this application will be clearly and completely described below in conjunction with the specific embodiments of this application and the corresponding drawings. Obviously, the embodiments described are only part of the embodiments of this application, not all of them. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0021] Patients receive sound and light stimulation for a certain period of time every day through a special device, and the frequency of the sound and light stimulation is set to 40 Hz. To this end, this application proposes a 40Hz sound and light audio player for the prevention and treatment of Alzheimer's disease in the elderly. The method of using physical factors to treat Alzheimer's disease is mainly a sound and light stimulation method. It mainly consists of an LED active light source as a light-emitting module and a speaker. Driven by a controller, it generates a fixed-frequency stroboscopic light signal and sound signal. After being transmitted to the brain through the optic nerve and auditory nerve, it stimulates the visual cortex, auditory cortex, hippocampus and other areas respectively, so that the gamma wave is ordered, the beta protein and tau protein are reduced, and the brain memory and cognition are enhanced.

[0022] The following describes in detail the technical solutions provided by various embodiments of the present application in conjunction with the accompanying drawings.

[0023] Reference Figure 2 The first embodiment of this application provides an acoustic and optical stimulation device for preventing and treating Alzheimer's disease. The device is used to generate sound of a specific frequency and includes a microcontroller, a power supply, and a voice module (including an audio amplifier). The power supply supplies power to the microcontroller, voice module (including the audio amplifier module), speaker, and storage module. The storage module is used to store 40Hz audio. The microcontroller controls the voice module to play the 40Hz audio stored in the storage module through the speaker.

[0024] Reference Figure 3 The second embodiment of the present application provides an acoustic and light stimulation device for preventing and treating Alzheimer's disease. The acoustic and light stimulation device can also be used to generate flashes of a specific frequency. The device includes a microcontroller, a power supply, a light control module and an LED lamp. The power supply supplies power to the microcontroller, the light control module and the LED lamp. The microcontroller is used to generate a PWM wave with a certain frequency and duty cycle. The light control module controls the flashing frequency of the LED lamp according to the PWM wave generated by the microcontroller.

[0025] Reference Figure 4 The third embodiment of the present application provides an acoustic and light stimulation device for preventing and treating Alzheimer's disease. The acoustic and light stimulation device can also be used to generate flashes of a specific frequency. The device includes a microcontroller, a power supply, a motor drive module and an LED lamp. The power supply supplies power to the microcontroller, the light control module and the LED lamp. The microcontroller is used to control the motor drive module to generate a PWM wave with a certain frequency and duty cycle. The motor drive module controls the flashing frequency of the LED lamp according to the generated PWM wave.

[0026] The microcontroller used in the first, second and third embodiments of the present application may be a microcontroller (MCU) or a programmable logic FPGA, or an LED driver control chip such as PCA9685, as well as control chips for various power supplies. The microcontroller has a PWM circuit and can generate a PWM waveform. For example, the PWM generating circuit in the timer is directly used. A dedicated PWM generating circuit has been integrated in the timer module. The user only needs to configure the registers of the module and configure the PWM frequency and duty cycle in the registers. After the software enables this function, a precise PWM waveform can be output.

[0027] The sound and light stimulation device of the present application can be used to generate sound of a specific frequency alone or to generate flashes of a specific frequency alone, or can generate sound of a specific frequency and flashes of a specific frequency simultaneously.

[0028] Reference Figure 1 The fourth embodiment of the present application provides an acousto-optic stimulation device that can simultaneously generate sound and flashes of a specific frequency. The acousto-optic stimulation device includes a microcontroller, a motor driver, a power supply, a light control module, and an audio amplifier. The power supply supplies power to the microcontroller, the motor driver, the light control module, and the audio amplifier. The difference between this embodiment and the first and second embodiments is that The microcontroller has a first timer and a second timer, the first timer is integrated with a first PWM generating circuit, and the second timer is integrated with a second PWM generating circuit. The first timer interrupt in the microcontroller is started according to the program setting to output a first PWM wave, and the second timer interrupt in the microcontroller is started according to the program setting to output a second PWM wave.

[0029] The first PWM wave controls the sound of a specific frequency. When the first timer interrupt in the microcontroller arrives, the first PWM wave is output to the motor driver. The motor driver amplifies the power of the first PWM wave and drives the audio amplifier to generate the sound of the specific frequency.

[0030] The second PWM wave controls the flash of a specific frequency. When the second timer interrupt in the microcontroller arrives, the second PWM wave is output to the motor driver. The motor driver amplifies the power of the second PWM wave and drives the light control module to generate a flash of a specific frequency.

[0031] In this embodiment, the motor driver is connected to the microcontroller and is used to amplify the power of the PWM wave, drive the audio amplifier to produce sound of a specific frequency or drive the lighting control module to output 40Hz flashes. In this application, the audio amplifier is, for example, a speaker.

[0032] In the embodiment of the present application, the microcontroller is an embedded circuit with an MCU as the core, and two timers are provided inside. The microcontroller is used to output a fixed frequency and duty cycle, and controls the average voltage or power level of the output signal by changing the duty cycle of the pulse signal, so as to achieve precise control and regulation of the output of 40Hz flashes or 40Hz frequency audio by relying solely on DC power supply, stimulating and promoting the brain's Y nerve oscillation, which is used to prevent and treat Alzheimer's disease.

[0033] Specifically, a microcontroller generates high and low level signals by changing the state of its I / O ports. When the I / O port is high, the power supply output voltage turns on, marking the beginning of a PWM cycle. When the I / O port is low, the power supply output voltage turns off, marking the end of a PWM cycle. A PWM cycle is defined as the time from one high level to the next high level. The ratio of the duration of the pulse to the total duration of a continuous operating period is the duty cycle. The longer the high level lasts, the higher the duty cycle, resulting in a higher output frequency and power.

[0034] The device provided by the present invention can conveniently adjust the output of 40Hz frequency light or 40Hz frequency audio by simply adjusting the high level duration within each cycle, realize and control the principle and precise control of the 40Hz frequency sound and light stimulation method, and generate sound of a specific frequency by playing a recorded audio amplifier, so that the elderly can easily obtain 40Hz sound stimulation to promote brain Y nerve oscillation, relieve anxiety, depression and irritability of Alzheimer's patients, thereby inhibiting and reducing the aggravation of Alzheimer's disease, and is used for the prevention and conditioning of Alzheimer's disease.

[0035] The fifth embodiment of the present application further provides a method for preventing and treating Alzheimer's disease through sound and light stimulation, the method comprising: Configure the frequency and duty cycle of the PWM wave to be output; Controlling the first timer or the second timer in the microprocessor through a program; When the first timer interrupt in the microcontroller arrives, the first PWM wave is output to the motor driver, and the motor driver amplifies the power of the first PWM wave and drives the audio amplifier to generate sound of a specific frequency; When the second timer interrupt in the microcontroller arrives, it outputs the second PWM wave to the motor driver, which amplifies the power of the second PWM wave and drives the light control module to generate a flash of a specific frequency.

[0036] The present invention is based on PWM photobiological neuromodulation therapy and customized small speaker with low frequency extension to 40Hz auditory sensory stimulation therapy. It is an integrated sound and light luminous audio player that is light, portable and easy to operate.

[0037] like Figure 4 As shown, the operation process of the device is as follows: configure the PWM channel, set the timer time, set the duty cycle, the counter starts counting, outputs the PWM wave, delays, determines whether to change the duty cycle, if so, resets the duty cycle, if not, continues to output the PWM wave.

[0038] The device uses sound and light stimulation with specific bands and frequencies to stimulate energy intensity. The MP3 player emits 40Hz audio and the light control module induces gama waves with a 40Hz frequency intensity. Auditory and visual stimulation induces neural oscillation waves. Non-invasive sensory stimulation is used to improve pathology and behavioral manifestations of neurodegenerative diseases, thereby manipulating the expression and precipitation removal of amyloid proteins, preventing and improving the symptoms of impaired gamma oscillations in patients, and enhancing cognition and memory, so as to alleviate and delay the progression of Alzheimer's disease.

[0039] The present invention does not require expensive costs, does not require a designated space or an appointment time, and is not restricted by time and space; patients can use it at home anytime and anywhere for prevention and conditioning, truly achieving the possibility and convenience of anytime and anywhere.

[0040] The foregoing is merely an embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various changes and variations. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present application should all be included within the scope of the claims of the present application.

Claims

1. An acoustic and optical stimulation device for preventing and treating Alzheimer's disease, characterized in that: The device is used to generate sound of a specific frequency. The device includes a microcontroller, a power supply, a voice module, a speaker and a storage module. The power supply supplies power to the microcontroller, voice module, speaker and storage module. The storage module is used to store audio with a frequency of 40Hz. The microcontroller is used to control the voice module to play the audio with a frequency of 40Hz stored in the storage module and play it through the speaker.

2. An acoustic and optical stimulation device for preventing and treating Alzheimer's disease, characterized in that: The device is used to generate flashes of a specific frequency. The device includes a microcontroller, a power supply, a light control module and an LED lamp. The power supply supplies power to the microcontroller, the light control module and the LED lamp. The microcontroller is used to generate a PWM wave with a certain frequency and duty cycle. The light control module controls the flashing frequency of the LED lamp according to the PWM wave generated by the microcontroller.

3. An acoustic and optical stimulation device for preventing and treating Alzheimer's disease, characterized in that: The device is used to generate flashes of a specific frequency. The device includes a microcontroller, a power supply, a motor drive module and an LED lamp. The power supply supplies power to the microcontroller, the light control module and the LED lamp. The microcontroller is used to control the motor drive module to generate a PWM wave with a certain frequency and duty cycle. The motor drive module controls the flashing frequency of the LED lamp based on the generated PWM wave.

4. An acoustic and optical stimulation device for preventing and treating Alzheimer's disease, characterized in that: Used to generate sound and flash of specific frequency, the sound and light stimulation device includes a microcontroller, a motor driver, a power supply, a light control module, and an audio amplifier; The power supply is used to power the microcontroller, motor driver, lighting control module and audio amplifier; The input end of the motor driver is connected to the microcontroller for power amplification of the PWM wave; The output end of the motor driver is connected to a driving audio amplifier or an audio amplifier, and is used to drive the audio amplifier to generate a sound of a specific frequency or drive the light control module to output a flash of a specific frequency.

5. The sound and light stimulation device for preventing and treating Alzheimer's disease according to any one of claims 1 to 4, characterized in that: The microcontroller is an embedded circuit with MCU as the core, which is internally provided with a timer and a PWM circuit. By setting the interrupt interval of the timer, the PWM circuit is controlled to output a PWM wave.

6. The sound and light stimulation device for preventing and treating Alzheimer's disease according to claim 4, characterized in that: The microcontroller has a first timer and a second timer, the first timer is integrated with a first PWM generating circuit, and the second timer is integrated with a second PWM generating circuit. The first timer interrupt in the microcontroller is started according to the program setting to output a first PWM wave, and the second timer interrupt in the microcontroller is started according to the program setting to output a second PWM wave.

7. The sound and light stimulation device for preventing and treating Alzheimer's disease according to claim 6, characterized in that: When a first timer interrupt occurs in the microcontroller, the microcontroller outputs a first PWM wave to the motor driver, and the motor driver amplifies the power of the first PWM wave and drives the audio amplifier to generate a sound of a specific frequency; When the second timer interrupt in the microcontroller arrives, the second PWM wave is output to the motor driver, and the motor driver amplifies the power of the second PWM wave to drive the light control module to generate a flash of a specific frequency.

8. The sound and light stimulation device for preventing and treating Alzheimer's disease according to claim 1, characterized in that: By adjusting the duty cycle of the PWM wave, a 40Hz frequency audio frequency is obtained.

9. The sound and light stimulation device for preventing and treating Alzheimer's disease according to any one of claims 2 to 4, characterized in that: By adjusting the duty cycle of the PWM wave, a flash frequency of 40Hz is obtained.

10. The sound and light stimulation device for preventing and treating Alzheimer's disease according to claim 4, characterized in that: By adjusting the duty cycle of the PWM wave, a 40Hz flash or a 40Hz audio frequency can be obtained.

11. A method for preventing and treating Alzheimer's disease using sound and light stimulation, the method comprising: Configure the frequency and duty cycle of the PWM wave to be output; control the first timer or the second timer in the microprocessor through the program; when the first timer interrupt in the microcontroller arrives, output the first PWM wave to the motor driver, the motor driver amplifies the power of the first PWM wave, and drives the audio amplifier to produce sound of a specific frequency; when the second timer interrupt in the microcontroller arrives, output the second PWM wave to the motor driver, the motor driver amplifies the power of the second PWM wave, and drives the light control module to produce flashes of a specific frequency.

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