Nicotine perfume and preparation method thereof

Abstract

The invention provides nicotine perfume and a preparation method thereof. The nicotine perfume comprises the following components: a nicotine sustained-release agent, an aromatic, a humectant, an antioxidant, a surfactant and a solvent, the aromatic comprises any one or a combination of at least two of balm essential oil, liquorice essential oil or cocoa essential oil. According to the nicotine perfume disclosed by the invention, the nicotine sustained-release agent and the aromatic are combined, so that the nicotine perfume not only can generate a fragrance which can make people have a pleasant mood and is full of gas, but also has a bitter taste of nicotine, and can bring people with pleasant experience and feeling close to cigarettes, and the nicotine sustained-release agent is added into the perfume, so that the nicotine perfume has the advantages that the taste is good; the nicotine perfume has the advantages that the nicotine can be slowly released, the nicotine perfume has the advantage of lasting fragrance, and in addition, the moisturizing agent and the antioxidant are added, so that the nicotine perfume has certain moisturizing and antioxidant effects after being sprayed to the skin.

Description

Technical Field

[0001] The invention belongs to the technical field of perfume products, and particularly relates to a nicotine perfume and a preparation method thereof. Background Art

[0002] Years of research have shown that with the development of the tobacco industry, many smokers have become highly dependent on the nicotine in tobacco products. Nicotine-like chemicals can stimulate the sympathetic nerves, cause damage to the vascular endothelium, and pose certain hazards to people's health. Therefore, as consumers' pursuit of a healthy lifestyle grows, more and more nicotine replacement products have emerged to help smokers alleviate withdrawal symptoms and assist in quitting smoking.

[0003] CN119791324A discloses a flavoring substance, a preparation method thereof, and a nicotine oral product. The nicotine oral product comprises a nicotine mixture comprising nicotine salts and a flavoring substance. The natural ingredients in the flavoring substance impart a unique, natural aroma to the nicotine oral product. These natural ingredients also improve the mouthfeel of the nicotine oral product, making it smoother and less irritating. Extracted from a combination of rooibos tea and agave, the flavoring substance possesses a herbal fragrance and honey flavor, resulting in a refreshing and natural taste. Furthermore, the agave extract contains sugar, which, compared to artificial sweeteners, provides a natural sweetness, further improving the product's taste and increasing its moisturizing properties, making the nicotine oral product more comfortable to use.

[0004] CN119817851A discloses a nicotine oral product that promotes transdermal absorption, relating to the technical field of nicotine oral products. The nicotine oral product contains a transdermal absorption enhancer selected from at least one of peppermint oil, wintergreen oil, menthol, azone and its derivatives, and sucrose monolaurate. This invention incorporates a transdermal absorption enhancer into the oral product to disrupt the phospholipid bilayer structure of the stratum corneum, increasing lipid fluidity and thereby altering the partition coefficient of nicotine in the oral mucosa. This increases the nicotine permeation rate and enhances the nicotine ingestion experience.

[0005] However, since the above-mentioned products are used directly in the oral cavity, they may cause nausea, vomiting, indigestion and other phenomena, which greatly affects the consumer's experience. Summary of the Invention

[0006] In view of the deficiencies in the prior art, the present invention aims to provide a nicotine perfume and a preparation method thereof.

[0007] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0008] In a first aspect, the present invention provides a nicotine perfume, wherein the components of the nicotine perfume include a nicotine sustained-release agent, a fragrance, a moisturizer, an antioxidant, a surfactant, and a solvent;

[0009] The fragrance includes any one of lemon balm essential oil, liquorice essential oil or cocoa essential oil, or a combination of at least two of them.

[0010] The nicotine perfume of the present invention, through the combination of a nicotine sustained-release agent and a fragrance, can not only produce a fragrance that makes people feel happy and full of vitality, but also has the "bitter" taste of nicotine, which can bring people a spiritual pleasure experience and feeling close to cigarettes. In addition, the nicotine sustained-release agent added to the perfume of the present invention can slowly release nicotine, and has the advantage of long-lasting fragrance. In addition, by adding a moisturizer and an antioxidant, the perfume has certain moisturizing and antioxidant effects after being sprayed on the skin.

[0011] Preferably, the components of the nicotine perfume include, by weight, 1-10 parts of a nicotine sustained-release agent, 1-5 parts of a fragrance, 1-5 parts of a moisturizer, 1-3 parts of an antioxidant, 0.1-2 parts of a surfactant, and 60-90 parts of a solvent.

[0012] The amount of the nicotine sustained-release agent added to the nicotine perfume of the present invention can be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts or 9 parts, etc.;

[0013] The amount of the fragrance added can be 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts or 4.5 parts, etc.;

[0014] The amount of the moisturizer added can be 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts or 4.5 parts, etc.;

[0015] The amount of the antioxidant added can be 1.1 parts, 1.3 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.7 parts or 2.9 parts, etc.;

[0016] The amount of the surfactant added can be 0.3 parts, 0.5 parts, 0.8 parts, 1 part, 1.2 parts, 1.5 parts, 1.7 parts or 1.9 parts, etc.;

[0017] The amount of the solvent added can be 65 parts, 70 parts, 75 parts, 80 parts or 85 parts, etc.

[0018] Preferably, the fragrance is a combination of lemon balm essential oil, liquorice essential oil and cocoa essential oil.

[0019] Preferably, the mass ratio of the lemon balm essential oil, liquorice essential oil and cocoa essential oil is (1-3):(0.5-1.5):(2-4).

[0020] Wherein "1-3" can be 1.1, 1.3, 1.5, 1.8, 2, 2.2, 2.5, 2.7 or 2.9, etc.;

[0021] “0.5-1.5” can mean 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3 or 1.4, etc.;

[0022] "2-4" can be 2.1, 2.3, 2.5, 2.8, 3, 3.2, 3.5, 3.7 or 3.9, etc.

[0023] The fragrance of the present invention adopts a combination of lemon balm, liquorice and cocoa essential oils. Through the layered superposition of fresh herbs, sweet herbs and bittersweet woods, it can neutralize the bitter taste of nicotine, thereby forming a complex fragrance characteristic of the perfume that is both energetic and calm.

[0024] Preferably, the moisturizing agent comprises any one of glycerin, butylene glycol, sorbitol, xylitol or polyethylene glycol, or a combination of at least two thereof.

[0025] Preferably, the antioxidant comprises any one of butylated hydroxytoluene, vitamin C, p-hydroxyacetophenone or tea polyphenols, or a combination of at least two thereof.

[0026] Preferably, the surfactant includes any one of cetearyl alcohol, glyceryl stearate, cholesterol, polyglyceryl-4 isostearate, ceteareth-20 or lecithin, or a combination of at least two thereof.

[0027] Preferably, the surfactant is a combination of cetearyl alcohol and cholesterol.

[0028] In the present invention, the surfactant is a combination of cetearyl alcohol and cholesterol. The combination of the two can make the remaining components evenly dispersed in the solvent to form a stable and clear solution, thereby making the perfume system more stable.

[0029] Preferably, the mass ratio of cetearyl alcohol to cholesterol is 1:(0.5-1.5), for example, it can be 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1, 1:1.1, 1:1.2, 1:1.3 or 1:1.4, etc.

[0030] Preferably, the solvent comprises an ethanol aqueous solution.

[0031] Preferably, the concentration of the ethanol aqueous solution is 40-60%, for example, it can be 41%, 43%, 45%, 48%, 50%, 52%, 55%, 57% or 59%.

[0032] Preferably, the nicotine sustained-release agent is prepared by the following method:

[0033] Beta-cyclodextrin is dissolved in water, nicotine and azone are added, the mixture is melted, and the mixture is cooled to obtain the nicotine sustained-release agent.

[0034] The present invention can better achieve the effect of sustained-release of nicotine by coating nicotine with beta-cyclodextrin, and can promote the release of nicotine by using azone, thereby making the perfume have an elegant fragrance and maintaining a long-lasting fragrance.

[0035] Preferably, the mass ratio of the β-cyclodextrin, nicotine and azone is (5-10):(1-3):(0.1-1).

[0036] Where "5-10" can be 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9 or 9.5, etc.;

[0037] "1-3" can be 1.1, 1.3, 1.5, 1.8, 2, 2.2, 2.5, 2.7 or 2.9, etc.;

[0038] “0.1-1” can be 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8 or 0.9, etc.

[0039] Preferably, the material-liquid ratio of the β-cyclodextrin to water is 0.1-0.5 g / mL, for example, 0.15 g / mL, 0.2 g / mL, 0.3 g / mL, 0.4 g / mL or 0.45 g / mL.

[0040] Preferably, the melting temperature is 100-120°C, for example, 102°C, 105°C, 108°C, 110°C, 112°C, 115°C or 118°C.

[0041] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0042] In a second aspect, the present invention provides a method for preparing the nicotine perfume according to the first aspect, the preparation method comprising:

[0043] (1) mixing a fragrance, a moisturizing agent, an antioxidant, a surfactant, and a solvent to obtain a mixed solution;

[0044] (2) After heating, adding nicotine sustained-release agent, and mixing evenly to obtain the nicotine perfume.

[0045] Preferably, the mixing in step (1) is carried out in a stirring manner, the stirring speed is 100-300 rpm (for example, it can be 120 rpm, 150 rpm, 180 rpm, 200 rpm, 220 rpm, 250 rpm or 280 rpm, etc.), and the time is 10-30 min (for example, it can be 12 min, 15 min, 18 min, 20 min, 22 min, 25 min or 28 min, etc.).

[0046] Preferably, the temperature in step (2) is raised to 50-60°C, for example, 51°C, 53°C, 55°C, 57°C or 59°C.

[0047] Preferably, the mixing in step (2) is carried out in a stirring manner, the stirring speed is 300-500 rpm (for example, it can be 320 rpm, 350 rpm, 380 rpm, 400 rpm, 420 rpm, 450 rpm or 480 rpm, etc.), and the time is 10-30 min (for example, it can be 12 min, 15 min, 18 min, 20 min, 22 min, 25 min or 28 min, etc.).

[0048] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0049] Compared with the prior art, the present invention has the following beneficial effects:

[0050] The nicotine perfume of the present invention, through the combination of a nicotine sustained-release agent and a fragrance, can not only produce a fragrance that makes people feel happy and full of vitality, but also has the "bitter" taste of nicotine, which can bring people a spiritual pleasure experience and feeling close to cigarettes. In addition, the nicotine sustained-release agent added to the perfume of the present invention can slowly release nicotine, and has the advantage of long-lasting fragrance. In addition, by adding a moisturizer and an antioxidant, the perfume has certain moisturizing and antioxidant effects after being sprayed on the skin. DETAILED DESCRIPTION

[0051] The technical solution of the present invention is further described below by way of specific embodiments. It should be understood by those skilled in the art that the embodiments are merely to help understand the present invention and should not be regarded as specific limitations of the present invention.

[0052] The raw materials involved in the examples or comparative examples of the present invention can be used as long as they are purchased from regular dealers.

[0053] Example 1

[0054] This embodiment provides a nicotine perfume, the components of which are 8 parts of a nicotine sustained-release agent, 4 parts of a fragrance, 2 parts of glycerin, 2 parts of sorbitol, 2 parts of butylated hydroxytoluene, 1.5 parts of a surfactant, and a solvent (50% ethanol aqueous solution) supplemented to 100 parts;

[0055] The fragrance is lemon balm essential oil, liquorice essential oil and cocoa essential oil in a mass ratio of 2:1:3;

[0056] The surfactant is cetearyl alcohol and cholesterol in a mass ratio of 1:1.

[0057] The preparation method of the nicotine perfume is:

[0058] (1) dissolving β-cyclodextrin in water (solid-liquid ratio of 0.4 g / mL), adding nicotine and azone, wherein the mass ratio of β-cyclodextrin, nicotine and azone is 8:2:0.5, mixing, melting at 110° C., and cooling to obtain the nicotine sustained-release agent;

[0059] (2) mixing the fragrance, glycerin, sorbitol, butylated hydroxytoluene, surfactant, and solvent at 25° C. and 200 rpm for 20 min to obtain a mixed solution;

[0060] (3) After heating to 55° C., a nicotine sustained-release agent was added, and the mixture was mixed at 400 rpm for 20 minutes to obtain the nicotine perfume.

[0061] Example 2

[0062] This embodiment provides a nicotine perfume, the components of which are 9 parts of a nicotine sustained-release agent, 3 parts of a fragrance, 3 parts of glycerin, 2 parts of butylene glycol, 1 part of vitamin C, 2 parts of a surfactant, and a solvent (60% ethanol aqueous solution) supplemented to 100 parts;

[0063] The fragrance is lemon balm essential oil, liquorice essential oil and cocoa essential oil in a mass ratio of 3:0.5:4;

[0064] The surfactant is cetearyl alcohol and cholesterol in a mass ratio of 2:1.

[0065] The preparation method of the nicotine perfume is:

[0066] (1) dissolving β-cyclodextrin in water (solid-liquid ratio of 0.5 g / mL), adding nicotine and azone, wherein the mass ratio of β-cyclodextrin, nicotine and azone is 5:1:1, mixing, melting at 120° C., and cooling to obtain the nicotine sustained-release agent;

[0067] (2) mixing the fragrance, glycerin, butylene glycol, butylated hydroxytoluene, surfactant, and solvent at 25° C. and 100 rpm for 30 min to obtain a mixed solution;

[0068] (3) After heating to 50° C., a nicotine sustained-release agent was added, and the mixture was mixed at 500 rpm for 10 minutes to obtain the nicotine perfume.

[0069] Example 3

[0070] This embodiment provides a nicotine perfume, the components of which are 7 parts of a nicotine sustained-release agent, 5 parts of a fragrance, 1 part of sorbitol, 2 parts of xylitol, 3 parts of tea polyphenols, 1 part of a surfactant, and a solvent (40% ethanol aqueous solution) supplemented to 100 parts;

[0071] The fragrance is lemon balm essential oil, liquorice essential oil and cocoa essential oil in a mass ratio of 2:3:4;

[0072] The surfactant is cetearyl alcohol and cholesterol in a mass ratio of 2:3.

[0073] The preparation method of the nicotine perfume is:

[0074] (1) dissolving β-cyclodextrin in water (solid-liquid ratio of 0.3 g / mL), adding nicotine and azone, wherein the mass ratio of β-cyclodextrin, nicotine and azone is 10:3:0.5, mixing, melting and treating at 120° C., and cooling to obtain the nicotine sustained-release agent;

[0075] (2) mixing the fragrance, xylitol, sorbitol, butylated hydroxytoluene, surfactant, and solvent at 25° C. and 300 rpm for 10 min to obtain a mixed solution;

[0076] (3) After heating to 60° C., a nicotine sustained-release agent was added, and the mixture was mixed at 300 rpm for 30 minutes to obtain the nicotine perfume.

[0077] Example 4

[0078] This embodiment provides a nicotine perfume, which differs from Example 1 only in that the fragrance does not include lemon balm essential oil, and the reduced amount thereof is distributed among licorice essential oil and cocoa essential oil according to a mass ratio. The remaining components and preparation method are the same as those in Example 1.

[0079] Example 5

[0080] This embodiment provides a nicotine perfume, which differs from Example 1 only in that licorice essential oil is not included in the fragrance, and the reduced amount thereof is distributed among lemon balm essential oil and cocoa essential oil according to a mass ratio. The remaining components and preparation method are the same as those in Example 1.

[0081] Example 6

[0082] This embodiment provides a nicotine perfume, which differs from Example 1 only in that the fragrance does not include cocoa essential oil, and the reduced amount thereof is distributed among lemon balm essential oil and licorice essential oil according to a mass ratio. The remaining components and preparation method are the same as those in Example 1.

[0083] Example 7

[0084] This embodiment provides a nicotine perfume, which differs from Example 1 only in that cetearyl alcohol is not included in the surfactant, and the reduced amount is supplemented by cholesterol. The remaining components and preparation method are the same as those in Example 1.

[0085] Example 8

[0086] This embodiment provides a nicotine perfume, which differs from Example 1 only in that cholesterol is not included in the surfactant, and the reduced amount is supplemented by cetearyl alcohol. The remaining components and preparation method are the same as those in Example 1.

[0087] Example 9

[0088] This embodiment provides a nicotine perfume, which differs from embodiment 1 only in the preparation method. In the preparation method, step (1) comprises: dissolving β-cyclodextrin in water (solid-liquid ratio is 0.4 g / mL), adding nicotine, wherein the mass ratio of β-cyclodextrin to nicotine is 4:1, mixing, melting at 110° C., and cooling to obtain the nicotine sustained-release agent;

[0089] The remaining components and preparation methods are the same as those in Example 1.

[0090] Example 10

[0091] This embodiment provides a nicotine perfume, which differs from embodiment 1 only in the preparation method. In the preparation method, step (1) comprises: dissolving sodium alginate in water (solid-to-liquid ratio is 0.4 g / mL), adding nicotine and azone, wherein the mass ratio of sodium alginate, nicotine and azone is 8:2:0.5, mixing, melting at 110° C., and cooling to obtain the nicotine sustained-release agent;

[0092] The remaining components and preparation methods are the same as those in Example 1.

[0093] Comparative Example 1

[0094] This comparative example provides a nicotine perfume, which differs from Example 1 only in that the nicotine sustained-release agent is replaced with nicotine in the components, and the amount of nicotine used is 1 / 6 of the original sustained-release agent. The remaining components and preparation method are the same as those in Example 1.

[0095] Comparative Example 2

[0096] This comparative example provides a nicotine perfume, which differs from Example 1 only in that the components do not include a humectant, and the reduced amount is supplemented by water. The remaining components and preparation method are the same as those of Example 1.

[0097] Comparative Example 3

[0098] This comparative example provides a nicotine perfume, which differs from Example 1 only in that the components do not include an antioxidant, and the reduced amount is supplemented by water. The remaining components and preparation method are the same as those of Example 1.

[0099] Comparative Example 4

[0100] This comparative example provides a nicotine perfume, which differs from Example 1 only in that the components do not include a surfactant, and the reduced amount is supplemented by water. The remaining components and preparation method are consistent with Example 1. Since a uniformly dispersed and clear system could not be formed, it was not tested.

[0101] Test Example 1 Sensory Evaluation

[0102] The evaluation method involved 10 sensory evaluators, each assigned a separate evaluation form. Each evaluator experienced the nicotine perfumes of Examples 1-10 and Comparative Examples 1-3 and scored them in a blind evaluation. The highest and lowest scores were removed, and the average was calculated. The specific definitions of the sensory quality evaluation indicators are shown in Table 1, the scoring criteria are shown in Table 2, and the scoring results are shown in Table 3 (the average of each group was calculated, with one decimal place rounded).

[0103] Table 1

[0104]

[0105] Table 2

[0106]

[0107] Table 3

[0108]

[0109]

[0110] As can be seen from Table 3, the nicotine perfumes obtained in Examples 1-3 of the present invention can bring a sense of nicotine satisfaction after use, and the aroma is harmonious and pleasant, and also has the characteristics of long-lasting fragrance.

[0111] As can be seen from Examples 4-6, when the types of fragrances are not the combination specified in the present invention, the harmony of the perfume is poor;

[0112] It can be seen from Examples 9-10 that only by using the specific raw materials and methods of the present invention to prepare the nicotine sustained-release agent can the sensory experience of the perfume be better and the fragrance last longer.

[0113] As can be seen from Comparative Example 1, when pure nicotine is used instead of the nicotine sustained-release agent of the present invention, the harmony of the perfume is poor.

[0114] Test Example 2 Sustained Release and Stability

[0115] The absorbent tissue paper was soaked in the perfume of Examples 1-3, 7-10 and Comparative Example 1 for 6 hours, and naturally dried in a closed space at a constant temperature of 30°C to prepare a fragrance sheet. The prepared fragrance sheet was placed in a place with good indoor air flow for 10 days, 30 days, and 60 days, respectively, to test its sustained release and stability.

[0116] Sustained-release effect test: Accurately weigh 1.5g of the fragrance tablet into a 100mL conical flask, add 20mL of a methanol solution containing an internal standard, and extract in a thermostatic oscillator at 100rpm for 90 minutes. After extraction, allow the mixture to stand and separate into layers. Filter the supernatant through a 0.22μm organic phase filter. Nicotine content was determined using the following instrumental conditions. The results are shown in Table 4.

[0117] Gas chromatography-thermal conductivity detector (GC-TCD) analysis conditions:

[0118] An HP-INNOWAX capillary column (30 m × 0.32 mm × 0.25 μm) was used; the temperature program was as follows: the initial temperature was 80°C and maintained for 3 min, then increased to 250°C at a rate of 50°C / min and maintained for 5 min; the injection parameters were as follows: the injection volume was 1 μL, the split ratio was 20:1, and the injection port temperature was 250°C; the detector parameters were as follows: the TCD detector temperature was 260°C, high-purity helium (purity ≥99.999%) was used as the carrier gas, and the flow rate was 2.0 mL / min; the auxiliary gas flow rate was: the reference gas was 20 mL / min, and the tail gas was 9 mL / min.

[0119] Stability test: Observe whether the perfume shows any signs of turbidity or stratification. The results are shown in Table 4.

[0120] Table 4

[0121]

[0122]

[0123] As shown in Table 4, the nicotine perfume of the present invention has a long-lasting sustained-release effect (the reason why the nicotine concentration increases over time is that other substances in the perfume are released more quickly, resulting in an increase in the relative nicotine concentration). Furthermore, the choice of surfactant has a significant impact on the stability of the perfume. When the raw materials used to prepare the nicotine sustained-release agent differ from those of the present invention, the sustained-release effect of the perfume is poor. Furthermore, when pure nicotine is used in place of the nicotine sustained-release agent, the sustained-release effect of the perfume is significantly reduced.

[0124] The applicant states that while the above-described embodiments illustrate the nicotine perfume and its preparation method, the present invention is not limited to the aforementioned detailed method. This does not necessarily mean that the present invention must rely on the aforementioned detailed method for implementation. Those skilled in the art will appreciate that any improvements to the present invention, equivalent substitutions for raw materials in the present product, additions of auxiliary ingredients, and selection of specific methods, etc., fall within the scope of protection and disclosure of the present invention.

Claims

1. A nicotine perfume, characterized in that: The components of the nicotine perfume include a nicotine sustained-release agent, a fragrance, a moisturizer, an antioxidant, a surfactant and a solvent; The fragrance includes any one of lemon balm essential oil, liquorice essential oil or cocoa essential oil, or a combination of at least two of them.

2. The nicotine perfume according to claim 1, characterized in that The components of the nicotine perfume include, by weight, 1-10 parts of a nicotine sustained-release agent, 1-5 parts of a fragrance, 1-5 parts of a moisturizer, 1-3 parts of an antioxidant, 0.1-2 parts of a surfactant, and 60-90 parts of a solvent.

3. The nicotine perfume according to claim 1 or 2, characterized in that The fragrance is a combination of lemon balm essential oil, liquorice essential oil and cocoa essential oil.

4. The nicotine perfume according to any one of claims 1 to 3, characterized in that The moisturizing agent includes any one of glycerin, butylene glycol, sorbitol, xylitol or polyethylene glycol, or a combination of at least two thereof; Preferably, the antioxidant comprises any one of butylated hydroxytoluene, vitamin C, p-hydroxyacetophenone or tea polyphenols, or a combination of at least two thereof.

5. The nicotine perfume according to any one of claims 1 to 4, characterized in that The surfactant includes any one of cetearyl alcohol, glyceryl stearate, cholesterol, polyglyceryl-4 isostearate, ceteareth-20 or lecithin, or a combination of at least two of them.

6. The nicotine perfume according to any one of claims 1 to 5, characterized in that The solvent includes an ethanol aqueous solution; Preferably, the concentration of the ethanol aqueous solution is 40-60%.

7. The nicotine perfume according to any one of claims 1 to 6, characterized in that The nicotine sustained-release agent is prepared by the following method: Beta-cyclodextrin is dissolved in water, nicotine and azone are added, the mixture is melted, and the mixture is cooled to obtain the nicotine sustained-release agent.

8. The nicotine perfume according to claim 7, characterized in that The mass ratio of the β-cyclodextrin, nicotine and azone is (5-10):(1-3):(0.1-1); Preferably, the material-liquid ratio of nicotine to water is 0.1-0.5 g / mL; Preferably, the melting temperature is 100-120°C.

9. A method for preparing the nicotine perfume according to any one of claims 1 to 8, characterized in that: The preparation method comprises: (1) mixing a fragrance, a moisturizing agent, an antioxidant, a surfactant, and a solvent to obtain a mixed solution; (2) After heating, adding nicotine sustained-release agent, and mixing evenly to obtain the nicotine perfume.

10. The preparation method according to claim 9, characterized in that The mixing in step (1) is carried out by stirring at a speed of 500-800 rpm for 10-30 min; Preferably, step (2) is heated to 50-60°C; Preferably, the mixing in step (2) is carried out in a stirring manner, the stirring speed is 500-800 rpm, and the stirring time is 10-30 min.

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