A miticidal composition and use thereof

Abstract

The application belongs to the technical field of pesticide mite-killing, and discloses a mite-killing composition and application thereof. The mite-killing composition comprises active ingredient A and active ingredient B. The active ingredient A is a compound shown in formula I. The active ingredient B is selected from the group consisting of a heterocyclic mite-killing agent, a quinone mite-killing agent, a benzoyl acetonitrile mite-killing agent, a propylene nitrile mite-killing agent, an oxazole mite-killing agent, a pyrazole amide mite-killing agent, a biphenyl hydrazine mite-killing agent, an antibiotic mite-killing agent, an organic tin mite-killing agent, a tetrazine mite-killing agent, a thiazolidinone mite-killing agent and the like. The mite-killing composition has obvious synergistic effect, can effectively improve the activity on crop mites with the same amount of drugs, and can be used for preventing and treating mites on fruit trees, cotton, tea trees, ornamental plants, vegetables, cereals and the like.

Description

Technical Field

[0001] This invention belongs to the field of pesticide acaricide technology, and discloses an acaricide composition and its application. Background Technology

[0002] Agricultural mites belong to the phylum Arthropoda, class Arachnida, subclass Acari. Mite infestations and damage are severe in agricultural and forestry production and agricultural product storage, with cotton, fruit trees, vegetables, and tea being the most severely affected. Herbivorous mites are characterized by their small size, rapid reproduction, numerous generations, strong adaptability, and tendency to develop pesticide resistance, making them one of the most difficult pest communities to control. Important agricultural mites are primarily herbivorous, with the superfamily Tetranychoidea being the most important, followed by the superfamilies Eriophyoidea and Tarsonemoidea.

[0003] In recent years, the improper use of pesticides has led to mites rising from secondary pests to major pests, with a trend of increasing spread and severity in my country. With in-depth research on mites and pesticides, chemical control is increasingly emphasizing safety and selectivity while maintaining efficacy. Given the growing severity of mite infestations, the use of chemical agents to control mite outbreaks will remain an important control measure. However, factors such as pesticide resistance, a limited variety of new acaricides, and lagging technological updates in acaricide application have led to pesticide overuse, increased pollution, and greater difficulty in controlling mites. Therefore, there is an urgent need in production for efficient, safe, economical, and easy-to-use green acaricides. Based on the characteristics and development patterns of mites, researchers have continuously developed acaricides with novel mechanisms of action. However, compared to the need for effective mite control, acaricides not only suffer from a limited variety and unsatisfactory efficacy, but most also face problems such as a single mechanism of action, low specificity, easy induction of pesticide resistance in mites, and poor safety. Summary of the Invention

[0004] Based on the above, the purpose of this invention is to provide an acaricidal composition and its application. The acaricidal composition contains a compound of formula I and another acaricide, which can be applied to control mites on fruit trees, cotton, tea trees, ornamental plants, vegetables, and cereal crops. The acaricide has a significant synergistic effect on harmful mites, improves the safety of crops, effectively slows down the development and growth of mite resistance, reduces the amount of pesticides used, and reduces environmental pressure.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: an acaricidal composition, wherein the acaricidal composition comprises active ingredient A and active ingredient B, wherein active ingredient A is a compound represented by formula I: The active ingredient B is selected from any of the following acaricides: heterocyclic acaricides, quaternary ketoacid acaricides, benzoyl acetonitrile acaricides, oxazole acaricides, pyrazoleamide acaricides, bifenazate acaricides, antibiotic acaricides, organotin acaricides, tetrazine acaricides, thiazolidinone acaricides, sulfite acaricides, thiourea acaricides, sulfoxide acaricides, bridged cyclic amine acaricides, quinoline acaricides, quinazoline acaricides, pyridazinone acaricides, benzoylurea acaricides, methoxyacrylate acaricides, benzoate acaricides, pyrazole acaricides, pyrrole acaricides, pyrimidine acaricides, naphthoquinone acaricides, pyridazine acaricides, pyrethroid acaricides, bio-based acaricides, and other acaricides.

[0006] Furthermore, the active ingredient A is a compound represented by Formula I: The active ingredient B is selected from heterocyclic acaricides: pyridaben, azoxystrobin; quaternary ketoacid acaricides: spirotetramat, spirodiclofen, spirodiclofen, spirodiclofen diester, quaternary ketoacid, quaternary ketoacid; benzoyl acetonitrile acaricides: diflufenicol; oxazole acaricides: etoxazole, fluxametamide, isocycloseram, pyridaben; pyrazolamide acaricides: pyridaben, azoxystrobin, pyflubumide, etoxazole, nicofluprole. Bifenazate acaricides: bifenazate; Antibiotic acaricides: abamectin, methyl abamectin benzoate, liuyangmycin, huaguangmycin, imibamectin; Organotin acaricides: triazole tin, fenbutatin; Tetraazine acaricides: tetradifon, flufenoxam; Thiazolidinedion acaricides: thiamethoxam; Sulfite acaricides: propargite; Thiourea acaricides: difenoazone, difenoconazole; Sulfoxide acaricides: flupentiofenox; Bridged cyclic amine acaricides: acynonapyr; Quinoline acaricides Acaricides: floctoquin; Quinazoline acaricides: quinafen; Pyridazinone acaricides: pyridaben; Benzoylurea acaricides: lufenuron, flufenoxuron, flufenoxuron; Methoxyacrylate acaricides: pyrimethanil, flufenoxuron, pyrimethanil; Benzoate acaricides: amidoflumet; Pyrazole acaricides: acetamiprid, vaniliprole, fipronil; Pyrrole acaricides: chlorfenapyr, bromfenoxuron; Pyrimidine acaricides: pyrimethanil; Naphthoquinone acaricides: cypermethrin; Pyridazine acaricides: pyridaben; Pyrethroid acaricides: lambda-cyhalothrin, deltamethrin, cypermethrin, bifenthrin, flufenoxuron, deltamethrin, lambda-cyhalothrin; Bio-derived acaricides: matrine, veratrine, azadirachtin, pyrethroids, rotenone, pine miticide, olive miticide; Other acaricides: any one of the following: profenofos, mivorilaner, modoflaner, tigolaner, umifoxolaner, trifluralin, and fluazinam.

[0007] Furthermore, the active ingredient is selected from heterocyclic acaricides: pyridaben, azoxystrobin; quaternary ketoacid acaricides: spirotetramat, spirodiclofen, spirodiclofen; benzoyl acetonitrile acaricides: dicofol; oxazole acaricides: etoxazole, cyprodinil; pyrazolamide acaricides: azoxystrobin, etoxazole; bifenazate acaricides: bifenazate; antibiotic acaricides: abamectin, methyl abamectin benzoate; organotin acaricides: triazole tin; tetrazine acaricides: tetrazine... Acaricides include: fenpyroxene and flufenoxuron; thiazolidinone acaricides: thiamethoxam; sulfite acaricides: propargite; thiourea acaricides: difenoconazole; quinazoline acaricides: quinfenoxuron; pyridazinone acaricides: pyridaben; benzoylurea acaricides: lufenuron; pyrazole acaricides: acetamiprid; pyrrole acaricides: chlorfenapyr; pyrethroid acaricides: lambda-cyhalothrin, bifenthrin, flufenoxuron; other acaricides: any one of profenofos and fluazinam.

[0008] Furthermore, the mass ratio of active ingredient A to active ingredient B is 1:80 to 80:1;

[0009] Furthermore, the mass ratio of active ingredient A to active ingredient B is 1:75 to 75:1;

[0010] The mass ratio of active ingredient A to active ingredient B is 1:80 to 80:1; preferably, the mass ratio of active ingredient A to active ingredient B is 1:50 to 75:1.

[0011] Further, the active ingredient B is azoxystrobin, and the mass ratio of active ingredient A to active ingredient B is 1:45 to 35:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:12 to 12:1.

[0012] Alternatively, the active ingredient B is spirodiclofen, and the mass ratio of active ingredient A to active ingredient B is 1:50 to 50:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:20 to 50:1.

[0013] Alternatively, the active ingredient B is biphenylhydrazine ester, and the mass ratio of active ingredient A to active ingredient B is 1:25 to 40:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:12 to 35:1.

[0014] Alternatively, the active ingredient B is etoxazole, and the mass ratio of active ingredient A to active ingredient B is 1:36 to 55:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:18 to 45:1.

[0015] Alternatively, the active ingredient B is cypermethrin, and the mass ratio of active ingredient A to active ingredient B is 1:40 to 50:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:20 to 50:1.

[0016] Alternatively, the active ingredient B is avermectin, and the mass ratio of active ingredient A to active ingredient B is 1:10 to 80:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:5 to 70:1.

[0017] Alternatively, the active ingredient B is emamectin benzoate, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 60:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:10 to 50:1.

[0018] Alternatively, the active ingredient B is triazole tin, and the mass ratio of active ingredient A to active ingredient B is 1:45 to 50:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:25 to 40:1.

[0019] Alternatively, the active ingredient B is butyl ether urea, and the mass ratio of the active ingredient A to the active ingredient B is 1:40 to 42:1. Preferably, the mass ratio of the active ingredient A to the active ingredient B is 1:20 to 42:1.

[0020] Alternatively, the active ingredient B is pyridaben, and the mass ratio of active ingredient A to active ingredient B is 1:8 to 75:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:3 to 75:1.

[0021] Alternatively, the active ingredient B is propargite, and the mass ratio of active ingredient A to active ingredient B is 1:35 to 45:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:25 to 15:1.

[0022] Alternatively, the active ingredient B is chlorfenapyr, and the mass ratio of active ingredient A to active ingredient B is 1:36 to 38:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:24 to 22:1.

[0023] Alternatively, the active ingredient B is fluazinam, and the mass ratio of the active ingredient A to the active ingredient B is 1:40 to 40:1. Preferably, the mass ratio of the active ingredient A to the active ingredient B is 1:25 to 40:1.

[0024] Alternatively, the active ingredient B is lufenuron, and the mass ratio of the active ingredient A to the active ingredient B is 1:48 to 50:1. Preferably, the mass ratio of the active ingredient A to the active ingredient B is 1:24 to 50:1.

[0025] Alternatively, the active ingredient B is spirodiclofen, and the mass ratio of active ingredient A to active ingredient B is 1:40 to 30:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:20 to 30:1.

[0026] Alternatively, the active ingredient B is tetradifon, and the mass ratio of the active ingredient A to the active ingredient B is 1:48 to 48:1. Preferably, the mass ratio of the active ingredient A to the active ingredient B is 1:36 to 12:1.

[0027] Alternatively, the active ingredient B is etoxazole, and the mass ratio of active ingredient A to active ingredient B is 1:25 to 55:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:15 to 45:1.

[0028] Alternatively, the active ingredient B is thiamethoxam, and the mass ratio of the active ingredient A to the active ingredient B is 1:25 to 61:1. Preferably, the mass ratio of the active ingredient A to the active ingredient B is 1:6 to 50:1.

[0029] Alternatively, the active ingredient B is spirotetramat, and the mass ratio of active ingredient A to active ingredient B is 1:50 to 50:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:10 to 25:1.

[0030] Alternatively, the active ingredient B is high-efficiency cyhalothrin, and the mass ratio of active ingredient A to active ingredient B is 1:33 to 44:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:25 to 32:1.

[0031] Alternatively, the active ingredient B is fluoroacetate, and the mass ratio of active ingredient A to active ingredient B is 1:40 to 42:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:28 to 35:1.

[0032] Alternatively, the active ingredient B is cypermethrin, and the mass ratio of active ingredient A to active ingredient B is 1:45 to 40:1. Preferably, the mass ratio of active ingredient A to active ingredient B is 1:25 to 30:1.

[0033] Furthermore, the total weight of the acaricide composition is 100 wt%, and the total weight of active ingredient A and active ingredient B accounts for 0.5% to 90% of the total weight of the acaricide composition.

[0034] Furthermore, the total weight of the acaricide composition is 100 wt%, and the total weight of active ingredient A and active ingredient B accounts for 2% to 80% of the total weight of the acaricide composition.

[0035] Furthermore, in addition to the active ingredient, the acaricide composition also includes agriculturally acceptable auxiliary ingredients, which are selected from one or more of the following: wetting agents, dispersants, emulsifiers, thickeners, disintegrants, antifreeze agents, defoamers, solvents, preservatives, stabilizers, synergists, or carriers.

[0036] The wetting agent is selected from one or more of the following: alkylbenzene sulfonates, alkylnaphthalene sulfonates, lignin sulfonates, sodium dodecyl sulfate, sodium dioctyl succinate sulfonate, α-olefin sulfonates, alkylphenol polyoxyethylene ethers, castor oil polyoxyethylene ethers, alkylphenol ethoxylates, fatty alcohol ethoxylates, sodium fatty alcohol polyoxyethylene ether sulfate, silkworm excrement, soapberry powder, soapberry powder, SOPA, detergents, emulsifiers 2000 series, and wetting and penetrating agents F; and / or

[0037] The dispersant is selected from one or more of the following: lignin sulfonates, alkyl naphthalene sulfonates formaldehyde condensates, naphthalene sulfonates, tristyrylphenol ethoxylate phosphates, fatty alcohol ethoxylates, alkylphenol polyoxyethylene ethers, alkylphenol polyoxyethylene ether methyl ether condensates sulfates, fatty amine polyoxyethylene ethers, glycerol fatty acid ester polyoxyethylene ethers, polycarboxylates, polyacrylic acids, phosphates, EO-PO block copolymers, and EO-PO graft copolymers; and / or

[0038] The emulsifier is selected from one or more of the following: calcium dodecylbenzenesulfonate, alkylphenol formaldehyde resin polyoxyethylene ether, phenethylphenol polyoxyethylene polyoxypropylene ether, fatty alcohol ethylene oxide-propylene oxide copolymer, styrene-phenol polyoxyethylene ether, castor oil polyoxyethylene ether, and alkylphenol ether phosphate; and / or

[0039] The thickener is selected from one or more of xanthan gum, organobentonite, gum arabic, sodium alginate, magnesium aluminum silicate, carboxymethyl cellulose, and silica; and / or

[0040] The disintegrant is selected from one or more of sodium sulfate, ammonium sulfate, aluminum chloride, sodium chloride, ammonium chloride, bentonite, glucose, sucrose, starch, cellulose, urea, sodium carbonate, sodium bicarbonate, citric acid, and tartaric acid; and / or

[0041] Antifreeze is selected from one or more of alcohols, alcohol ethers, chlorinated hydrocarbons, and inorganic salts; and / or

[0042] Defoamer selected from C 10 -C 20Saturated fatty acid compounds, silicone oil, silicone compounds, C8-C 10 One or more of the fatty alcohols; and / or

[0043] The solvent is selected from one or more of benzene, toluene, xylene, mesitylene, methanol, ethanol, isopropanol, n-butanol, dimethyl sulfoxide, dimethylformamide, cyclohexanone, hydrocarbon carbonates, diesel oil, solvent oil, vegetable oil, vegetable oil derivatives, and water; and / or

[0044] The preservative is selected from one or more of propionic acid, sodium propionate, sorbic acid, sodium sorbate, potassium sorbate, benzoic acid, sodium benzoate, sodium p-hydroxybenzoate, methyl p-hydroxybenzoate, Kathon, and 1,2-benzisothiazolin-3-one; and / or

[0045] The stabilizer is selected from one or more of the following: disodium hydrogen phosphate, oxalic acid, succinic acid, adipic acid, borax, 2,6-di-tert-butyl-p-cresol, triethanolamine oleate, epoxidized vegetable oil, kaolin, bentonite, attapulgite, silica, talc, montmorillonite, and starch; and / or

[0046] Synergists are selected from synergistic phosphorus, synergistic ether; and / or

[0047] The carrier is selected from one or more of the following: ammonium salts, ground natural minerals, ground artificial minerals, silicates, resins, waxes, solid fertilizers, water, organic solvents, mineral oils, vegetable oils, and vegetable oil derivatives.

[0048] The carrier can be a solid carrier or a liquid carrier;

[0049] The solid carrier includes: minerals, plant materials, synthetic fillers, and inorganic salts;

[0050] The minerals mentioned include silicates, carbonates, sulfates, and oxides.

[0051] The silicates are selected from at least one of kaolin, sepiolite, pearl clay, montmorillonite, mica, vermiculite, pyrophyllite, and talc; the carbonates are selected from calcium carbonate or dolomite; the sulfates are selected from at least one of ammonium sulfate, sodium sulfate, and calcium sulfate; the oxides are selected from at least one of quicklime, magnesium lime, and diatomaceous earth; the plant materials are selected from at least one of citrus pomace, corn cob, rice husk powder, rice husk, soybean straw powder, tobacco powder, walnut shell, and sawdust; the synthetic fillers are selected from at least one of precipitated calcium carbonate hydrate, precipitated calcium carbonate, and silica; and the inorganic salts are selected from potassium chloride or sodium chloride.

[0052] The liquid carrier includes water and an organic solvent;

[0053] The water is preferably deionized water;

[0054] The organic solvent is selected from at least one of aromatic hydrocarbons, chlorinated aliphatic hydrocarbons, aliphatic hydrocarbons, alcohols, ethers, ketones, special solvents, vegetable oils, and methylated vegetable oils;

[0055] The aromatic hydrocarbon is selected from at least one of benzene, xylene, trimethylbenzene, and toluene; the chlorinated aliphatic hydrocarbon is selected from at least one of chloroform, dichloromethane, chloroform, carbon tetrachloride, and polychlorinated ethanes; the aliphatic hydrocarbon is selected from at least one of petroleum fractions, cyclohexane, light mineral oil, and paraffin; the alcohol is selected from at least one of methanol, ethanol, isopropanol, butanol, isobutanol, ethylene glycol, propylene glycol, glycerol, and fatty alcohols; the ether is selected from at least one of propylene glycol ethyl ether, propylene glycol methyl ether, and petroleum ether; the ketone is selected from acetone, At least one of cyclohexanone, isoflurone, N-methylpyrrolidone, and N-octylpyrrolidone; the special solvent is selected from at least one of dimethylformamide, dimethyl sulfoxide, polyethylene glycol, and acetonitrile; the vegetable oil is selected from at least one of peanut oil, soybean oil, linseed oil, castor oil, and rapeseed oil; the methylated vegetable oil is selected from at least one of methyl oleate, methyl oleate, methyl laurate, methyl stearate, methyl myristate, methyl hexadecanoate, methyl octanoate, methyl caprylate, methyl cocoate, and mixed fatty acid methyl esters;

[0056] Furthermore, the acaricidal composition can be prepared into an agriculturally acceptable dosage form, wherein the dosage form is a liquid formulation and / or a solid formulation. The liquid formulation is selected from soluble concentrates, soluble gels, oils, spreading oils, emulsifiable concentrates, latexes, dispersible liquids, ointments, water emulsions, oil emulsions, microemulsions, lipid suspensions, microcapsule suspensions, oil suspensions, dispersible oil suspensions, suspension emulsions, microcapsule suspension-suspension, microcapsule suspension-water emulsions, or microcapsule suspension-suspension emulsions. The solid formulation is selected from powders, granules, balls, tablets, strips, wettable powders, oil-dispersible powders, emulsion powders, water-dispersible granules, emulsion granules, water-dispersible tablets, soluble powders, soluble tablets, or soluble granules.

[0057] Furthermore, the liquid formulation is selected from emulsifiable concentrates, water emulsions, and microemulsions, and the solid formulation is selected from water-dispersible granules;

[0058] The present invention also discloses the use of the acaricidal composition described above for the control of crop mites.

[0059] Furthermore, the crops mentioned are those that harm fruit trees, cotton, tea trees, ornamental plants, vegetables, and cereal crops, and the mites mentioned are mites of the superorder Ephemeroptera, which includes mites of the families Tetranychidae, Eriophyta, and Tardiformes.

[0060] Furthermore, the Tetranychus superfamily includes two-spotted spider mite, carmine spider mite, citrus spider mite, truncate spider mite, citrus spider mite, Kanzawa spider mite, apple spider mite, citrus spider mite and / or wheat spider mite; the Gallia superfamily includes citrus rust mite, wolfberry gall mite, grape gall mite, tea orange gall mite, jujube gall mite, and spiny gall mite; and the Tardiformes superfamily includes rice tardiformes and tea tardiformes.

[0061] The beneficial effects of this invention are:

[0062] 1) The acaricidal composition of the present invention rationally combines compounds with different mechanisms of action, which has a significant synergistic effect on harmful mites, can reduce the amount of pesticides used, reduce production costs, and reduce environmental pressure.

[0063] 2) The acaricidal composition of the present invention has a good control effect on mites at all growth stages and can be widely used for the control of agricultural mites. Detailed Implementation

[0064] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0065] Formulation preparation example

[0066] Preparation Example 1: 28% Compound I·Azoxystrobin aqueous emulsion (1:3)

[0067] Formula: 7% of Formula I compound, 21% of azoxystrobin, 3% of alkylphenol polyoxyethylene ether, 4% of styrene-phenol polyoxyethylene ether, 10% of cyclohexanone, 0.1% of xanthan gum, 5% of ethylene glycol, 0.2% of benzoic acid, 1% of silicone defoamer, and deionized water to make up the balance;

[0068] Preparation method: According to the formulation ratio in the example, the active ingredient is dissolved in the solvent and an emulsifier is added to dissolve it into a homogeneous oil phase. Deionized water and antifreeze are mixed together to form a homogeneous aqueous phase. Under high-speed shearing, the aqueous phase is added to the oil phase to form a well-dispersed water emulsion product.

[0069] Preparation Example 2: 35% Formula I compound pyridaben water-dispersible granules (1:6)

[0070] Formula: 5% of Formula I compound, 30% of abamectin, 5% of sodium lignosulfonate, 3% of alkyl naphthalene sulfonate, 5% of silica, 8% of ammonium sulfate, 8% of corn starch, and diatomaceous earth to make up the balance;

[0071] Preparation method: According to the formulation ratio in the example, add the active ingredient to the carrier, and add surfactants and other functional additives therein, mix, and after air jet pulverization, add 10-25% water, and then knead, granulate, dry and sieve to obtain water-dispersible granules; or spray water, granulate and dry the pulverized powder in a fluidized bed granulator, and then sieve to obtain the product.

[0072] Preparation Example 3: 30% Formula I compound·spirodiclofen water-dispersible granules (1:1)

[0073] Formula: 15% of compound I, 15% of spirodiclofen, 3% of alkylnaphthalene sulfonate formaldehyde condensate, 3% of ammonium sulfate, 4% of alkylnaphthalene sulfonate, 2% of sodium benzoate, 0.1% of sodium sorbate, and kaolin to make up the balance;

[0074] Preparation method: Same as in preparation example 2.

[0075] Preparation Example 4: 20% Compound I·Spirodiclofen EC (4:1)

[0076] Formula: 16% of compound I, 4% of spirodiclofen, 4% of alkyl naphthalene sulfonate formaldehyde condensate, 3% of nonylphenol polyoxyethylene ether, 2% of phenethyl powder polyoxyethylene ether, 10% of dimethyl sulfoxide, and xylene to make up the balance;

[0077] Preparation method: The measured active ingredients, solvent, and co-solvent are added to a mixing tank and stirred to dissolve them. Then, the emulsifier is added, and the remaining solvent is used to make up the balance. The mixture is stirred evenly in a mixing tank and filtered to obtain the emulsifiable oil required by this invention.

[0078] Preparation Example 5: 18% Compound I·Biphenylhydrazine Emulsifiable Concentrate (1:1)

[0079] Formula: 9% of compound I, 9% of biphenylhydrazine ester, 18% of propylene carbonate, 3% of calcium dodecylbenzenesulfonate, 15% of fatty alcohol polyoxyethylene ether, and methyl oleate to make up the balance;

[0080] Preparation method: Same as in preparation example 4.

[0081] Preparation Example 6: 32% Compound I·Biphenylhydrazine water-dispersible granules (3:1)

[0082] Formula: 24% of compound I, 8% of biphenylhydrazine, 8% of sodium dodecylbenzenesulfonate, 5% of sodium polycarboxylate, 3% of sucrose, 10% of silica, and kaolin to make up the balance;

[0083] Preparation method: Same as in preparation example 2.

[0084] Preparation Example 7: 20% Compound I·Ethoxyfenozide Emulsifiable Concentrate (9:1)

[0085] Formula: 18% of compound I, 2% of etoxazole, 15% of propylene carbonate, 5% of calcium dodecylbenzenesulfonate, 10% of fatty alcohol polyoxyethylene ether, 5% of soybean oil, and methyl oleate to make up the balance;

[0086] Preparation method: Same as in preparation example 4.

[0087] Preparation Example 8: 36% Formula I compound·etoxazole water-dispersible granules (3:1)

[0088] Formula: 27% of compound I, 9% of etoxazole, 3% of sodium dodecylbenzenesulfonate, 3% of naphthalenesulfonate formaldehyde condensate, 2% of sodium polycarboxylate, 3% of sodium dodecyl sulfate, 10% of ammonium sulfate, and starch to make up the balance;

[0089] Preparation method: Same as in preparation example 2.

[0090] Preparation Example 9: 35% Compound I of Formula 1·Iridyl acetamiprid water-dispersible granules (4:1)

[0091] Formula: 28% of compound I, 7% of cypermethrin, 3% sodium lignosulfonate, 5% of pyridoxine BX, 1% sodium dodecylbenzenesulfonate, and kaolin to make up the balance;

[0092] Preparation method: Same as in preparation example 2.

[0093] Preparation Example 10: 36% Formula I compound pyridaben water-dispersible granules (1:3)

[0094] Formula: 9% compound I, 27% cypermethrin, 3% sodium lignosulfonate, 3% sodium dodecylbenzenesulfonate, 5% sodium dodecyl sulfate, 20% starch, and kaolin to make up the balance;

[0095] Preparation method: Same as in preparation example 2.

[0096] Preparation Example 11: 4.1% Formula I compound avermectin water-dispersible granules (40:1)

[0097] Formula: 4% of Formula I compound, 0.1% of abamectin, 5% of naphthalene sulfonate formaldehyde condensate, 2% of sodium polycarboxylate, 5% of sodium dodecyl sulfate, and the balance is made up of light calcium carbonate.

[0098] Preparation method: Same as in preparation example 2.

[0099] Preparation Example 12: 2.2% Formula I compound avermectin microemulsion (10:1)

[0100] Formula: 2% of Formula I compound, 0.2% of abamectin, 15% of xylene, 18% of cyclohexanone, 10% of alkylphenol polyoxyethylene ether, 2% of EO-PO block copolymer, 3% of sodium sulfate of fatty alcohol polyoxyethylene ether, 5% of glycerol, 0.05% of silicone defoamer, and deionized water to make up the balance.

[0101] Preparation method: According to the formulation of the preparation example, the active ingredients, solvent, emulsifier, etc. are mixed evenly to obtain the oil phase, the antifreeze and water are mixed evenly to obtain the aqueous phase, the oil phase is added to the aqueous phase under stirring and stirred evenly, and shearing is continued for 10 minutes. Then, silicone oil defoamer is added and stirred evenly to obtain small droplets with oil phase particles of 0.01 to 0.1 micrometers, which is the microemulsion of the present invention.

[0102] Preparation Example 13: 1.8% Formula I compound emamectin benzoate aqueous emulsion (5:1)

[0103] Formula: 1.5% of compound I, 0.3% of emamectin benzoate, 10% of xylene, 10% of cyclohexanone, 4% of calcium dodecylbenzenesulfonate, 5% of ethylene oxide-propylene oxide copolymer, 5% of glycerol, 1% of glycerin, 0.05% of silicone defoamer, 0.2% of xanthan gum, 0.01% of Kathon, and deionized water to make up the balance;

[0104] Preparation method: Same as in preparation example 1.

[0105] Preparation Example 14: 2.2% Formula I compound emamectin benzoate emulsifiable concentrate (10:1)

[0106] Formula: 2% of Formula I compound, 0.2% of emamectin benzoate, 18% of propylene glycol methyl ether, 12% of alkylphenol polyoxyethylene ether, 2% of calcium dodecylbenzenesulfonate, 10% of DMF, and methyl oleate to make up the balance;

[0107] Preparation method: Same as in preparation example 4.

[0108] Preparation Example 15: 21% Compound I Triazole Tin Emulsifiable Concentrate (1:2)

[0109] Formulation: 7% of Formula I compound, 14% of triazole tin, 13% of EO / PO block copolymer, 10% of dimethyl sulfoxide, 10% of propylene glycol methyl ether, 2% of calcium dodecylbenzenesulfonate, and xylene to make up the balance;

[0110] Preparation method: Same as in preparation example 4.

[0111] Preparation Example 16: 30% Formula I compound·triazole tin water-dispersible granules (1:1)

[0112] Formula: 15% of compound I, 15% of triazole tin, 8% of sodium lignosulfonate, 2% of bleaching powder BX, 1% of sodium dodecylbenzenesulfonate, 8% of glucose, and corn starch to make up the balance;

[0113] Preparation method: Same as in preparation example 2.

[0114] Preparation Example 17: 15% Formula I compound butyl ether urea microemulsion (3:2)

[0115] Formula: 9% compound I, 6% butyl ether urea, 12% xylene, 18% cyclohexanone, 8% alkylphenol polyoxyethylene ether, 3% EO-PO block copolymer, 3% sodium sulfate of fatty alcohol polyoxyethylene ether, 5% glycerol, 0.05% silicone defoamer, and deionized water to make up the balance.

[0116] Preparation method: Same as in preparation example 12.

[0117] Preparation Example 18: 25% Formula I compound butyl ether urea water-dispersible granules (4:1)

[0118] Formula: 20% of compound I, 5% of butyl ether urea, 5% of sodium dodecylbenzene sulfonate, 4% of phenethylphenol polyether phosphate salt, 5% of polycarboxylate, 5% of starch, 3% of silica, and kaolin to make up the balance;

[0119] Preparation method: Same as in preparation example 2.

[0120] Preparation Example 19: 43% Compound I·pyridaben microemulsion (42:1)

[0121] Formula: 42% of Formula I compound, 1% of pyridaben, 20% of cyclohexanone, 12% of styrene-phenol polyoxyethylene ether, 1% of alkyl aryl polyoxyethylene ether polyoxypropylene ether, 2% of fatty alcohol polyoxyethylene ether sulfate, 5% of ethylene glycol, 0.1% of Kathon, 0.1% of silicone defoamer, and deionized water to make up the balance;

[0122] Preparation method: Same as in preparation example 12.

[0123] Preparation Example 20: 13% Compound I of Formula 1·pyridaben emulsifiable concentrate (12:1)

[0124] Formula: 12% of Formula I compound, 1% of pyridaben, 20% of propylene carbonate, 8% of polyoxyethylene sorbitan monooleate, 6% of castor oil polyoxyethylene ether ether, 2% of calcium dodecylbenzene sulfonate, and the balance is made up with rosin-based vegetable oil.

[0125] Preparation method: Same as in preparation example 4.

[0126] Preparation Example 21: 24% Compound I·Propylthiazoline Emulsifiable Oil (1:3)

[0127] Formula: 6% of Formula I compound, 18% of propargite, 30% of acetophenone, 8% of castor oil polyoxyethylene ether, 6% of alkylphenol polyoxyethylene ether, 2% of calcium dodecylbenzenesulfonate, and methyl oleate to make up the balance;

[0128] Preparation method: Same as in preparation example 4.

[0129] Preparation Example 22: 18% Formula I compound·propyritin microemulsion (1:8)

[0130] Formula: 2% Compound I, 16% Propyleneone, 15% Cyclohexanone, 5% Xylene, 3% Isothiazol polyoxyethylene ether, 5% Styrene polyoxyethylene ether, 5% Calcium dodecylbenzenesulfonate, 5% Glycerol, 0.1% Benzo[a]isothiazolinone potassium, 0.5% Glycerin, 0.1% Xanthan gum, 0.05% Silicone defoamer, deionized water to make up the balance;

[0131] Preparation method: Same as in preparation example 12.

[0132] Preparation Example 23: 20% Compound I of Formula 1·chlorfenapyr emulsifiable concentrate (3:2)

[0133] Formula: 12% of compound I, 8% of chlorfenapyr, 18% of N-methylpyrrolidone, 10% of fatty alcohol polyoxyethylene ether, 1% of calcium dodecylbenzenesulfonate, 10% of DMF, and methyl oleate to make up the balance;

[0134] Preparation method: Same as in preparation example 4.

[0135] Preparation Example 24: 35% Formula I compound chlorfenapyr water-dispersible granules (2:3)

[0136] Formula: 14% of compound I, 21% of chlorfenapyr, 1% of castor oil polyoxyethylene ether, 3% of sodium dodecylbenzenesulfonate, 5% of tristyrylphenol ethoxylate phosphate, 5% of sodium sulfate, 5% of sodium carboxymethyl cellulose, and kaolin to make up the balance;

[0137] Preparation method: Same as in preparation example 2.

[0138] Preparation Example 25: 24% Formula I compound·fludinamide emulsifiable concentrate (3:1)

[0139] Formulation: 18% of Formula I compound, 6% of fluazinam, 12% of EO / PO block copolymer, 15% of acetophenone, 11% of N-octylpyrrolidone, 1% of polycarboxylate, and the balance is made up with trimethylbenzene;

[0140] Preparation method: Same as in preparation example 4.

[0141] Preparation Example 26: 20% Formula I compound·fludinamide water-dispersible granules (1:3)

[0142] Formula: 5% of Formula I compound, 15% of fluazinam, 6% of sodium dodecylbenzenesulfonate, 3% of fatty alcohol ethoxylate, 3% of alkylphenol polyoxyethylene ether, 4% of calcium lignosulfonate, 3% of sodium sulfate, 3% of sodium carboxymethyl cellulose, 4% of bentonite, and the balance is made up with silica.

[0143] Preparation method: Same as in preparation example 2.

[0144] Preparation Example 27: 10% Compound I of Formula 1·Lufenuron Emulsifiable Concentrate (1:1)

[0145] Formula: 5% of compound I, 5% of lufenuron, 12% of styrene-based phenol polyoxyethylene ether, 15% of acetophenone, 10% of N-octylpyrrolidone, 1% of calcium dodecylbenzenesulfonate, and solvent oil to make up the balance.

[0146] Preparation method: Same as in preparation example 4.

[0147] Preparation Example 28: 20% Compound I Lufenuron Microemulsion (1:4)

[0148] Formula: 4% compound I, 16% lufenuron, 10% xylene, 10% cyclohexanone, 3% calcium dodecylbenzenesulfonate, 3% ethylene oxide-propylene oxide copolymer, 3% alkyl aryl polyoxyethylene ether polyoxypropylene ether, 4% ethylene glycol, 0.5% glycerin, 0.05% silicone defoamer, 0.2% xanthan gum, 0.01% Kathon, deionized water to make up the balance;

[0149] Preparation method: Same as in preparation example 12.

[0150] Preparation Example 29: 21% Formula I compound·spirodiclofen emulsifiable concentrate (4:3)

[0151] Formula: 12% Formula I compound, 9% spirodiclofen, 12% DMF, 10% castor oil polyoxyethylene ether, 1% calcium dodecylbenzenesulfonate, 20% propylene carbonate, and the balance is made up with tricresylbenzene.

[0152] Preparation method: Same as in preparation example 4.

[0153] Preparation Example 30: 24% Formula I compound·spirodiclofen microemulsion (1:5)

[0154] Formula: 4% of compound I, 20% of spirodiclofen, 10% of castor oil polyoxyethylene ether, 4% of EO-PO block copolymer, 1% of sodium fatty alcohol polyoxyethylene ether sulfate, 20% of cyclohexanone, 5% of propylene glycol, 0.1% of silicone defoamer, 1% of glycerin, 0.1% of Kathon, 0.1% of xanthan gum, and deionized water to make up the balance.

[0155] Preparation method: Same as in preparation example 12.

[0156] Preparation Example 31: 32% Formula I compound·tetradamine water-dispersible granules (1:1)

[0157] Formula: 16% of compound I, 16% of tetradifon, 6% sodium dodecylbenzenesulfonate, 8% calcium lignosulfonate, 3% sodium sulfate, 5% sodium carboxymethyl cellulose, and kaolin to make up the balance.

[0158] Preparation method: Same as in preparation example 2.

[0159] Preparation Example 32: 16% Tetradamine Emulsifiable Concentrate (1:3) of Formula I Compound

[0160] Formula: 4% of Formula I compound, 12% of tetradifon, 25% of propylene carbonate, 10% of xylene, 5% of castor oil polyoxyethylene ether, 1% of calcium dodecylbenzene sulfonate, and the balance made up with rosin-based vegetable oil;

[0161] Preparation method: Same as in preparation example 4.

[0162] Preparation Example 33: 11% Formula I compound·etoxazole emulsifiable concentrate (10:1)

[0163] Formula: 10% of compound I, 1% etoxazole, 20% propylene carbonate, 4% calcium dodecylbenzenesulfonate, 3% corn oil, 12% isotridecyl alcohol polyoxyethylene ether, and methyl oleate to make up the balance;

[0164] Preparation method: Same as in preparation example 4.

[0165] Preparation Example 34: 30% Formula I compound·etoxazole water-dispersible granules (5:1)

[0166] Formula: 25% compound I, 5% etoxazole, 8% sodium lignosulfonate, 5% naphthalenesulfonate, 3% sodium dodecylbenzenesulfonate, 4% styrene-based powder BX, 10% ammonium sulfate, and kaolin to make up the balance;

[0167] Preparation method: Same as in preparation example 2.

[0168] Preparation Example 35: 6.8% Formula I compound·thiamethoxam emulsifiable concentrate (33:1)

[0169] Formula: 6.6% of compound I, 0.2% of thiamethoxam, 3% of naphthalene sulfonate formaldehyde condensate, 4% of phenylethyl polyoxyethylene ether, 10% of castor oil polyoxyethylene ether, 1% of calcium dodecylbenzenesulfonate, 20% of propylene carbonate, and xylene to make up the balance.

[0170] Preparation method: Same as in preparation example 4.

[0171] Preparation Example 36: 6.3% Formula I compound·thiamethoxam aqueous emulsion (20:1)

[0172] Formula: 6% of compound I, 0.3% of thiamethoxam, 3% of nonylphenol polyoxyethylene ether, 5% of styrene-phenol polyoxyethylene, 8% of cyclohexanone, 0.1% of xanthan gum, 5% of glycerol, 0.2% of sodium benzoate, 1% of silicone defoamer, and deionized water to make up the balance.

[0173] Preparation method: Same as in preparation example 1.

[0174] Preparation Example 37: 21% Formula I compound·spirotetramat emulsifiable concentrate (2:1)

[0175] Formula: 14% of compound I, 7% of spirotetramat, 15% of propylene carbonate, 3% of sodium lignosulfonate, 3% of phenethyl polyoxyethylene ether, 10% of nonylphenol polyoxyethylene ether, and xylene to make up the balance;

[0176] Preparation method: Same as in preparation example 4.

[0177] Preparation Example 38: 30% Formula I compound·spirotetramat water-dispersible granules (5:1)

[0178] Formula: 25% of compound I, 5% of spirotetramat, 12% of sodium lignosulfonate, 2% of naphthalenesulfonate formaldehyde condensate, 3% of sodium dodecyl sulfate, 5% of silica, and bentonite to make up the balance.

[0179] Preparation method: Same as in preparation example 2.

[0180] Preparation Example 39: 17% Formula I compound·high-efficiency cyhalothrin emulsifiable concentrate (14:3)

[0181] Formula: 14% of compound I, 3% of high-efficiency cyhalothrin, 12% of propylene carbonate, 3% of sodium lignosulfonate, 3% of styrene-phenol polyoxyethylene ether, 10% of alkylphenol polyoxyethylene ether, and the balance is made up with thiol.

[0182] Preparation method: Same as in preparation example 4.

[0183] Preparation Example 40: 16% Formula I compound·high-efficiency cyhalothrin suspension (3:1)

[0184] Formula: 12% of compound I, 4% of high-efficiency cyhalothrin, 1% of sodium dodecylbenzenesulfonate, 2% of naphthalenesulfonate formaldehyde condensate, 1% of triphenylethylphenol polyoxyethylene ether phosphate, 0.2% of xanthan gum, 1% of magnesium aluminum silicate, 5% of propylene glycol, 0.01% of potassium benzisothiazolinone, 0.5% of silicone oil, and deionized water to make up the balance;

[0185] Preparation method: According to the formula ratio, the active ingredients, surfactants and other functional additives are placed in the reaction vessel in sequence, water is added and mixed evenly, and then subjected to high-speed shearing, wet sand milling and finally homogenization filtration to obtain the suspension product.

[0186] Preparation Example 41: 12% Compound I of Formula 1·Cypermethrin EC (5:7)

[0187] Formula: 5% of compound I, 7% of cypermethrin, 20% of N-methylpyrrolidone, 12% of triphenylethylphenol polyoxyethylene ether, 2% of calcium dodecylbenzenesulfonate, 10% of DMF, and methyl oleate to make up the balance.

[0188] Preparation method: Same as in preparation example 4.

[0189] Preparation Example 42: 10% Compound I of Formula 1·Cypermethrin EC (1:4)

[0190] Formula: 2% of Formula I compound, 8% of cypermethrin, 15% of block polyether, 12% of acetophenone, 8% of N-octylpyrrolidone, 1% of calcium dodecylbenzenesulfonate, and the balance is made up with trimethylbenzene.

[0191] Preparation method: Same as in preparation example 4.

[0192] Preparation Example 43: 20% Formula I compound·diflubenzuron suspension (1:1)

[0193] Formula: 10% of Compound I, 10% of fluoroacetate, 1% of fatty alcohol polyoxyethylene ether, 3% of alkyl aryl polyoxyethylene ether polyoxypropylene ether, 2% of tristyrene phenol ethoxylate phosphate, 2% of alkylphenol polyoxyethylene ether sodium phosphate, 2% of magnesium aluminum silicate, 0.2% of carboxyethyl cellulose, 1% of sodium benzoate, 5% of ethylene glycol, 0.5% of silicone oil, and deionized water to make up the balance;

[0194] Preparation method: Same as preparation example 40.

[0195] Preparation Example 44: 18% Formula I compound·diflubenzuron suspension (5:1)

[0196] Formula: 15% of Compound I, 3% of tebufenozide, 1% sodium alkylphenol ether sulfosuccinate, 3% ammonium triphenylphenol polyoxyethylene ether sulfate, 2% alkylaryl polyoxyethylene ether polyoxypropylene ether, 1% lignin sulfonate, 1.5% magnesium aluminum silicate, 0.1% Kathon, 0.1% xanthan gum, 5% ethylene glycol, 0.5% silicone oil, and deionized water to make up the balance;

[0197] Preparation method: Same as preparation example 40.

[0198] Indoor activity test:

[0199] Example 1: Indoor toxicity testing and screening of compound ratios

[0200] The activity of compound I against Tetranychus carmine was determined by rationally combining it with other acaricides.

[0201] Experimental targets: adult mites, nymphs, and eggs of the Tetranychus cinnabarinus.

[0202] Adult and nymph test methods: Indoor testing was conducted according to NY / T 1154.13-2008 "Guidelines for Indoor Bioassay Testing of Pesticides - Insecticides Part 13: Leaf Disc Spraying Method". Uniformly grown broad bean leaves were selected and perforated to create leaf discs. A damp sponge was placed in a petri dish, filter paper was placed on top, and the leaf discs were placed on the filter paper. Each petri dish contained leaf discs, and 15 mites were inoculated onto each leaf disc. The active ingredient was prepared as a stock solution using an organic solvent, and then five series concentrations were prepared using a 0.1% Tween 80 aqueous solution in equal proportions. The spray pressure of the spray tower was adjusted to a stable state. The spray head was cleaned twice with acetone and then twice with distilled water. The petri dish was placed on the bottom of the spray tower for spraying, with a spray volume of 1 mL. After the solution settled for 1 minute, it was removed and transferred to a temperature of (25±1)℃ and a photoperiod of L:D=(16:8)h for rearing and observation. Each treatment was repeated 4 times, and a treatment without the drug (containing all organic solvents and emulsifiers) was set up as a blank control. After 48 hours of drug treatment, the mortality of the test mites was checked, and the total number of mites and the number of dead mites were recorded.

[0203] Mite egg test method: The experiment was conducted according to NY / T 1154.5-2006 "Guidelines for Indoor Bioassay of Pesticides - Insecticides Part 5: Ovicidal Activity Test - Immersion Method". A 30mm × 20mm white hardboard was used, and newly laid eggs were attached to it with double-sided tape to create egg cards, with 30 eggs per card. The egg cards were immersed in the pesticide solution for 5 seconds and then transferred to normal conditions (25±5℃, 16h light / d) for cultivation. Each treatment was repeated 4 times, with a blank control included. After all eggs in the blank control hatched, the number of hatched and unhatched eggs in each treatment were recorded.

[0204] Data statistics and analysis:

[0205] Data processing for adult and nymphal mites: Based on the survey data, calculate the mortality rate for each treatment. Calculate using the following formula:

[0206]

[0207] In the formula:

[0208] P – Mortality rate, expressed as a percentage (%);

[0209] K represents the number of dead insects, in heads;

[0210] N represents the total number of insects treated, in units of heads.

[0211]

[0212] In the formula:

[0213] P1 – Corrected mortality rate, in percentage (%);

[0214] P t —The mortality rate is expressed as a percentage (%).

[0215] P0 – Mortality rate in the blank control group, expressed as a percentage (%).

[0216] If the control mortality rate is <5%, no correction is needed; if the control mortality rate is between 5% and 20%, correction should be performed according to the corrected mortality rate formula; if the control mortality rate is >20%, the trial needs to be repeated.

[0217] Data processing of mite egg survey: Based on the survey data, the egg hatching inhibition rate for each treatment was calculated using the following formula:

[0218]

[0219] In the formula:

[0220] I1—hatching inhibition rate;

[0221] N0 – Number of unhatched eggs;

[0222] N—Total number of eggs processed;

[0223]

[0224] In the formula:

[0225] I2 – Corrected hatching inhibition rate;

[0226] I t —Treatment of hatching inhibition rate;

[0227] I0 – Hatching inhibition rate in the blank control group;

[0228] The obtained experimental data were analyzed using the DPS statistical analysis system to determine the toxicity regression equation, correlation coefficient, and LC. 50 The value is used to evaluate the activity of the test reagent on the biological sample.

[0229] The co-toxicity coefficient (CTC value) of the mixture is calculated using the following formula:

[0230]

[0231] In the formula:

[0232] ATI – Actual Measured Toxicity Index of Mixtures;

[0233] S – LC50 of standard acaricides 50 The unit is milligrams per liter (mg / L);

[0234] M – LC of the mixture 50 The unit is milligrams per liter (mg / L).

[0235] TTI = TI A ×P A +TI B ×P B

[0236] In the formula:

[0237] TTI – Theoretical Toxicity Index of Mixtures;

[0238] TI A —A. Toxicity index of drug A;

[0239] P A —Percentage content of drug A in the mixture, expressed as percentage (%);

[0240] TI B —Toxicity index of drug B;

[0241] P B —Percentage content of agent B in the mixture, expressed as percentage (%).

[0242]

[0243] In the formula:

[0244] CTC – Cotoxicity Coefficient;

[0245] ATI – Actual Measured Toxicity Index of Mixtures;

[0246] TTI – Theoretical Toxicity Index of Mixtures.

[0247] The co-toxicity coefficient of the compound is ≥120, which shows a synergistic effect; CTC≤80 shows an antagonistic effect; and 80<CTC<120 shows an additive effect.

[0248] The experimental results (see Table 1) show that the compound of formula I mixed with azoxystrobin in the range of 1:45 to 35:1 has a good synergistic effect on adult Tetranychus cinnabarinus. The mass ratio of the two is 1:12 to 12:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0249] Table 1. Results of indoor activity assays of compound I mixed with azoxystrobin on adult Tetranychus cinnabarin.

[0250] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.0713 + 1.5966x 0.9969 16.1440 / Azoxystrobin (B) y = 2.2354 + 1.7654x 0.9997 36.8122 / A:B = 1:45 y = 2.7091 + 1.5646x 0.9964 29.1219 122.984 A:B = 1:25 y = 2.5684 + 1.6843x 0.9977 27.7772 126.307 A:B = 1:12 y = 3.1437 + 1.3315x 0.9965 24.7797 135.240 A:B = 1:6 y = 2.9928 + 1.5117x 0.9986 21.2727 146.293 A:B = 1:3 y = 3.1192 + 1.5243x 0.9943 17.1340 162.757 A:B = 1:1 y = 3.2596 + 1.5208x 0.9858 13.9450 160.952 A:B = 3:1 y = 3.5882 + 1.3114x 0.9954 11.9282 157.442 A:B = 6:1 y = 3.5997 + 1.3039x 0.9963 11.8562 148.039 A:B = 12:1 y = 3.5711 + 1.3154x 0.9952 12.1993 138.309 A:B = 25:1 y = 3.6507 + 1.2179x 0.9962 12.8221 128.686 A:B = 35:1 y = 3.6379 + 1.2233x 0.9961 12.9866 126.282

[0251] The experimental results (see Table 2) show that the compound of formula I mixed with spirodiclofen in the range of 1:50 to 50:1 has a good synergistic effect on adult Tetranychus cinnabarinus; when the mass ratio of the two is 1:20 to 50:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0252] Table 2. Results of indoor activity assays of compound I mixed with spirodiclofen against adult Tetranychus cinnabarin.

[0253] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.0713 + 1.5966x 0.9969 16.1440 / Spirodiclofen (B) y = 3.8455 + 1.6190x 0.9942 5.1658 / A:B = 1:50 y = 4.0967 + 1.4487x 0.9991 4.2028 124.574 A:B = 1:20 y = 4.1381 + 1.4127x 0.9993 4.0753 131.001 A:B = 1:10 y = 4.1540 + 1.4361x 0.9978 3.8825 141.821 A:B = 1:8 y = 4.1059 + 1.5973x 0.9958 3.6287 153.995 A:B = 1:5 y = 4.1986 + 1.4584x 0.9921 3.5440 164.394 A:B = 1:1 y = 4.0197 + 1.5107x 0.9947 4.4557 175.664 A:B = 5:1 y = 3.8822 + 1.3159x 0.9916 7.0710 168.597 A:B = 8:1 y = 3.7976 + 1.3441x 0.9976 7.8456 166.464 A:B = 10:1 y = 3.8653 + 1.2021x 0.9890 8.7889 153.945 A:B = 20:1 y = 3.5189 + 1.4510x 0.9851 10.4879 139.784 A:B = 50:1 y = 3.4596 + 1.4319x 0.9995 11.9056 130.176

[0254] The experimental results (see Table 3) show that the mixture of compound I and biphenylhydrazine in the range of 1:25 to 40:1 has a good synergistic effect on adult Tetranychus cinnabarinus; when the mass ratio of the two is 1:12 to 35:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0255] Table 3. Results of indoor activity assays of compound I mixed with biphenylhydrazine on adult Tetranychus cinnabarinus.

[0256] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.0713 + 1.5966x 0.9969 16.1440 / Biphenylhydrazine (B) y = 3.7428 + 2.0362x 0.9974 4.1440 / A:B = 1:25 y = 4.1639 + 1.5576x 0.9961 3.4417 123.949 A:B = 1:20 y = 4.2361 + 1.4644x 0.9979 3.3238 129.252 A:B = 1:12 y = 4.1944 + 1.5844x 0.9918 3.2246 136.306 A:B = 1:7 y = 4.2014 + 1.6110x 0.9892 3.1312 145.902 A:B = 1:3 y = 4.2349 + 1.4328x 0.9914 3.4196 148.843 A:B = 7:1 y = 3.7527 + 1.4788x 0.9908 6.9739 169.968 A:B = 10:1 y = 3.5726 + 1.5833x 0.9967 7.9714 160.320 A:B = 14:1 y = 3.3915 + 1.7341x 0.9981 8.4636 159.881 A:B = 20:1 y = 3.4213 + 1.6132x 0.9985 9.5194 149.039 A:B = 35:1 y = 3.5432 + 1.3944x 0.9992 11.0867 134.775 A:B = 40:1 y = 3.6947 + 1.2102x 0.9989 11.9834 125.832

[0257] The experimental results (see Table 4) show that the compound of formula I mixed with etoxazole in the range of 1:36 to 55:1 has a good synergistic effect on adult Tetranychus cinnabarinus; when the mass ratio of the two is 1:18 to 45:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0258] Table 4. Results of indoor activity assays of compound I mixed with etoxazole and adult Tetranychus cinnabarinus.

[0259]

[0260]

[0261] The experimental results (see Table 5) show that the compound of formula I mixed with cypermethrin in the range of 1:40 to 50:1 has a good synergistic effect on adult Tetranychus cinnabarinus; when the mass ratio of the two is 1:20 to 20:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0262] Table 5. Results of indoor activity assays of compound I mixed with cyproterone and adult Tetranychus cinnabarin.

[0263] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.0713 + 1.5966x 0.9969 16.1440 / Cyclopyralid (B) y = 3.8608 + 1.4480x 0.9920 6.1199 / A:B = 1:40 y = 4.0610 + 1.3327x 0.9974 5.0650 122.685 A:B = 1:20 y = 4.0262 + 1.4959x 0.9957 4.4767 140.871 A:B = 1:12 y = 4.0212 + 1.5763x 0.9996 4.1778 153.834 A:B = 1:6 y = 3.9953 + 1.5856x 0.9979 4.3015 156.122 A:B = 1:3 y = 3.9276 + 1.6222x 0.9992 4.5824 158.093 A:B = 4:1 y = 4.1554 + 0.9845x 0.9936 7.2106 168.646 A:B = 8:1 y = 3.4693 + 1.6430x 0.9902 8.5448 159.843 A:B = 10:1 y = 3.5553 + 1.5187x 0.9972 8.9398 157.181 A:B = 15:1 y = 3.4404 + 1.5534x 0.9984 10.0923 145.108 A:B = 20:1 y = 3.3800 + 1.5528x 0.9965 11.0469 135.567 A:B = 50:1 y = 3.4176 + 1.4637x 0.9987 12.0522 129.782

[0264] The experimental results (see Table 6) show that the compound of Formula I mixed with abamectin in the range of 1:10 to 80:1 has a good synergistic effect on adult Tetranychus carmineus; when the mass ratio of the two is 1:5 to 70:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is significant.

[0265] Table 6. Results of indoor activity assays of compound I mixed with avermectin on adult Tetranychus cinnabarinus.

[0266]

[0267]

[0268] The experimental results (see Table 7) show that the compound of formula I mixed with emamectin benzoate in the range of 1:15 to 60:1 has a good synergistic effect on adult spider mites; when the mass ratio of the two is 1:10 to 50:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0269] Table 7. Results of indoor activity assays of compound I mixed with emamectin benzoate on adult Tetranychus cinnabarinus.

[0270] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.0713 + 1.5966x 0.9969 16.1440 / Emamectin benzoate (B) y = 5.5264 + 1.6878x 0.9897 0.4876 / A:B = 1:15 y = 5.5710 + 1.4709x 0.9976 0.4091 126.879 A:B = 1:10 y = 5.6082 + 1.5402x 0.9986 0.4028 132.757 A:B = 1:5 y = 5.5018 + 1.3714x 0.9958 0.4306 135.069 A:B = 1:1 y = 5.2093 + 1.1796x 0.9981 0.6646 142.433 A:B = 5:1 y = 4.6819 + 1.5057x 0.9935 1.6266 156.262 A:B = 10:1 y = 4.3590 + 1.5973x 0.9966 2.5560 161.166 A:B = 20:1 y = 4.0781 + 1.4999x 0.9974 4.1174 155.038 A:B = 30:1 y = 3.9307 + 1.4770x 0.9974 5.2963 149.730 A:B = 40:1 y = 3.8133 + 1.4584x 0.9849 6.5119 139.032 A:B = 50:1 y = 3.8860 + 1.2789x 0.9990 7.4308 133.321 A:B = 60:1 y = 3.8096 + 1.2674x 0.9978 8.6939 121.656

[0271] The experimental results (see Table 8) show that the compound of formula I mixed with triazole tin in the range of 1:45 to 50:1 has a good synergistic effect on adult Tetranychus cinnabarinus; when the mass ratio of the two is 1:25 to 40:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0272] Table 8. Results of indoor activity assays of compound I mixed with triazole tin on adult Tetranychus cinnabarinus.

[0273]

[0274]

[0275] The experimental results (see Table 9) show that the compound of formula I mixed with pyridaben in the range of 1:8 to 75:1 has a good synergistic effect on adult Tetranychus cinnabarinus; when the mass ratio of the two is 1:3 to 75:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0276] Table 9. Results of indoor activity assays of compound I mixed with pyridaben on adult Tetranychus cinnabarinus.

[0277] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.0713 + 1.5966x 0.9969 16.1440 / Pyridaben (B) y = 6.1550 + 1.6954x 0.9906 0.2082 / A:B = 1:8 y = 6.0959 + 1.5059x 0.9967 0.1872 124.919 A:B = 1:4 y = 6.0709 + 1.5340x 0.9948 0.2004 129.448 A:B = 1:3 y = 6.0170 + 1.5029x 0.9925 0.2105 131.312 A:B = 1:1 y = 5.8595 + 1.5472x 0.9961 0.2783 147.718 A:B = 2:1 y = 5.6338 + 1.6183x 0.9934 0.4059 150.011 A:B = 12:1 y = 4.7240 + 1.5567x 0.9963 1.5042 155.822 A:B = 24:1 y = 4.4247 + 1.5072x 0.9983 2.4081 165.058 A:B = 35:1 y = 4.2645 + 1.5386x 0.9977 3.0065 171.768 A:B = 42:1 y = 4.2195 + 1.5197x 0.9938 3.2630 177.970 A:B = 51:1 y = 4.1675 + 1.3396x 0.9958 4.1828 156.137 A:B = 75:1 y = 4.0925 + 1.2263x 0.9966 5.4959 146.352

[0278] The experimental results (see Table 10) show that the compound of formula I and propargite in a mass ratio of 1:35 to 45:1 have a good synergistic effect on adult Tetranychus carmineus; when the mass ratio of the two is 1:25 to 15:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0279] Table 10 Results of Indoor Activity Determination Tests of Compound I with Proteobacterium cinnabarinum Adult Mites in a Specific Mixture.

[0280] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.0713 + 1.5966x 0.9969 16.1440 / Propylthiazolinone (B) y = 2.5538 + 1.6134x 0.9996 32.8227 / A:B = 1:35 y = 2.9085 + 1.4871x 0.9943 25.4960 125.145 A:B = 1:25 y = 2.9345 + 1.5185x 0.9967 22.9206 137.729 A:B = 1:15 y = 3.2323 + 1.3349x 0.9984 21.0994 146.127 A:B = 1:5 y = 3.1732 + 1.4494x 0.9966 18.2122 153.750 A:B = 4:7 y = 3.3653 + 1.4215x 0.9943 14.1239 168.928 A:B = 1:3 y = 3.1929 + 1.5077x 0.9987 15.7966 165.133 A:B = 7:4 y = 3.6333 + 1.2314x 0.9981 12.8779 153.777 A:B = 5:1 y = 3.6624 + 1.2455x 0.9988 11.8565 148.760 A:B = 15:1 y = 3.5069 + 1.3784x 0.9968 12.1122 137.659 A:B = 25:1 y = 3.6592 + 1.2084x 0.9963 12.8691 127.948 A:B = 45:1 y = 3.6593 + 1.1887x 0.9956 13.4217 121.626

[0281] The experimental results (see Table 11) show that the compound of formula I mixed with chlorfenapyr in the range of 1:26 to 38:1 has a good synergistic effect on adult Tetranychus cinnabarinus; the mass ratio of the two is 1:24 to 22:1, and the co-toxicity coefficient is greater than 130.

[0282] Table 11 Results of indoor activity assays of compound I mixed with chlorfenapyr and adult Tetranychus cinnabarinus.

[0283] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.0713 + 1.5966x 0.9969 16.1440 / Chlorfenapyr (B) y = 2.6214 + 1.6538x 0.9985 27.4323 / A:B = 1:36 y = 2.9180 + 1.5701x 0.9976 21.1868 127.077 A:B = 1:24 y = 2.9607 + 1.5673x 0.9989 20.0069 133.384 A:B = 1:12 y = 3.1545 + 1.4738x 0.9948 17.8728 145.652 A:B = 1:3 y = 3.1813 + 1.5410x 0.9959 15.1424 154.206 A:B = 2:3 y = 3.3959 + 1.4578x 0.9882 12.5998 170.135 A:B = 3:2 y = 3.4492 + 1.4844x 0.9844 11.0854 174.327 A:B = 3:1 y = 3.7399 + 1.2270x 0.9970 10.6406 169.119 A:B = 10:1 y = 3.7709 + 1.1943x 0.9953 10.6934 156.839 A:B = 16:1 y = 3.7557 + 1.1826x 0.9949 11.2755 146.729 A:B = 22:1 y = 3.7307 + 1.1797x 0.9957 11.9118 137.998 A:B = 38:1 y = 3.6907 + 1.1766x 0.9933 12.9644 125.854

[0284] The experimental results (see Table 12) show that the compound of formula I mixed with fluazinam in the range of 1:25 to 20:1 has a good synergistic effect on adult Tetranychus cinnabarinus; when the mass ratio of the two is 1:10 to 20:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0285] Table 12 Results of Indoor Activity Determination of Compound I Mixed with Fluazinam on Adult Tetranychus cinnabarinus

[0286] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.0713 + 1.5966x 0.9969 16.1440 / Fluazinam (B) y = 3.3979 + 1.7060x 0.9855 8.6912 / A:B = 1:40 y = 3.6120 + 1.5641x 0.9957 7.7161 113.920 A:B = 1:25 y = 3.6578 + 1.5553x 0.9961 7.2948 121.296 A:B = 1:10 y = 3.6821 + 1.6121x 0.9979 6.5690 138.102 A:B = 1:5 y = 3.7574 + 1.5383x 0.9971 6.4235 146.581 A:B = 1:3 y = 3.6913 + 1.6401x 0.9993 6.2799 156.454 A:B = 1:1 y = 3.8638 + 1.3461x 0.9913 6.9835 161.801 A:B = 3:1 y = 3.6479 + 1.5092x 0.9933 7.8682 168.959 A:B = 5:1 y = 3.4999 + 1.5572x 0.9987 9.1904 153.696 A:B = 10:1 y = 3.5849 + 1.3605x 0.9999 10.9673 136.556 A:B = 20:1 y = 3.5733 + 1.3261x 0.9988 11.9083 130.251 A:B = 40:1 y = 3.5060 + 1.3304x 0.9989 13.2721 119.147

[0287] The experimental results (see Table 13) show that the compound of formula I mixed with high-efficiency cyhalothrin in the range of 1:33 to 44:1 has a good synergistic effect on adult spider mites; when the mass ratio of the two is 1:25 to 44:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0288] Table 13 Results of Indoor Activity Determination of Compound I Mixed with High-Efficiency Cyfluthrin on Adult Tetranychus cinnabarinus

[0289]

[0290]

[0291] The experimental results (see Table 14) show that the compound of formula I mixed with tebufenozide in the range of 1:40 to 42:1 has a good synergistic effect on adult Tetranychus cinnabarinus; when the mass ratio of the two is 1:28 to 35:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0292] Table 14 Results of Indoor Activity Determination Tests on Adult Tetranychus cinnabarin with Compound I Mixed with Fenflufenicol

[0293] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.0713 + 1.5966x 0.9969 16.1440 / Fenfluroxyfen (B) y = 4.3965 + 1.5597x 0.9991 2.4373 / A:B = 1:40 y = 4.5603 + 1.4909x 0.9922 1.9721 126.202 A:B = 1:28 y = 4.6009 + 1.5579x 0.9955 1.8039 139.188 A:B = 1:14 y = 4.7196 + 1.2069x 0.9936 1.7074 151.314 A:B = 1:7 y = 4.7211 + 1.3563x 0.9996 1.6055 169.834 A:B = 1:1 y = 4.4550 + 1.4389x 0.9841 2.3919 177.064 A:B = 7:1 y = 4.0806 + 1.2918x 0.9938 5.1486 184.126 A:B = 14:1 y = 3.8163 + 1.3908x 0.9956 7.0975 165.436 A:B = 28:1 y = 3.7373 + 1.3163x 0.9997 9.1051 148.508 A:B = 35:1 y = 3.8029 + 1.1881x 0.9837 10.1774 137.194 A:B = 42:1 y = 3.64370 + 1.2992x 0.9968 11.0642 129.036

[0294] The experimental results (see Table 15) show that the compound of formula I mixed with cypermethrin in the range of 1:45 to 40:1 has a good synergistic effect on adult spider mites; when the mass ratio of the two is 1:25 to 30:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0295] Table 15 Results of Indoor Activity Determination of Compound I Mixed with Cypermethrin on Adult Tetranychus cinnabarinus

[0296]

[0297]

[0298] The experimental results (see Table 16) show that the compound of formula I mixed with lufenuron in the range of 1:48 to 50:1 has a good synergistic effect on the nymphs of Tetranychus cinnabarinus; when the mass ratio of the two is 1:24 to 24:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0299] Table 16 Results of Indoor Activity Assays of Compound I and Lufenuron Mixed with Tetranychus cinnabarin Nymphs

[0300] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.8387 + 1.1531x 0.9935 10.1651 / Lufenuron (B) y = 3.2806 + 1.6569x 0.9904 10.9074 / A:B = 1:48 y = 3.5350 + 1.5429x 0.9995 8.9026 122.337 A:B = 1:24 y = 3.6138 + 1.5146x 0.9984 8.2273 132.190 A:B = 1:12 y = 3.7236 + 1.4777x 0.9945 7.3079 148.421 A:B = 1:6 y = 3.7082 + 1.5667x 0.9996 6.6762 161.691 A:B = 1:3 y = 3.7619 + 1.5462x 0.9989 6.3201 169.489 A:B = 1:1 y = 3.8506 + 1.4693x 0.9986 6.0576 173.719 A:B = 3:1 y = 3.8080 + 1.4865x 0.9997 6.3369 163.188 A:B = 6:1 y = 3.8264 + 1.4500x 0.9998 6.4468 159.225 A:B = 12:1 y = 3.8241 + 1.4077x 0.9977 6.8450 149.286 A:B = 24:1 y = 3.8442 + 1.3299x 0.9988 7.3975 137.788 A:B = 50:1 y = 3.8106 + 1.2913x 0.9968 8.3382 122.073

[0301] The experimental results (see Table 17) show that the compound of formula I mixed with spirodiclofen in the range of 1:20 to 30:1 has a good synergistic effect on the nymphs of Tetranychus cinnabarinus; when the mass ratio of the two is 1:12 to 10:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0302] Table 17 Results of indoor activity assays of compound I mixed with spirodiclofen against Tetranychus cinnabarin nymphs.

[0303] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.8387 + 1.1531x 0.9935 10.1651 / Spirodiclofen (B) y = 3.5870 + 1.8071x 0.9832 6.0522 / A:B = 1:40 y = 3.9067 + 1.5192x 0.9969 5.2439 116.564 A:B = 1:20 y = 3.8928 + 1.6020x 0.9929 4.9108 125.664 A:B = 1:10 y = 3.9623 + 1.5168x 0.9938 4.8324 130.025 A:B = 1:5 y = 4.1034 + 1.3897x 0.9881 4.4176 146.909 A:B = 4:3 y = 3.8609 + 1.5694x 0.9951 5.3186 148.015 A:B = 1:1 y = 3.7876 + 1.6785x 0.9956 5.2765 143.791 A:B = 2:1 y = 3.9002 + 1.4199x 0.9991 5.9509 139.269 A:B = 3:4 y = 3.9333 + 1.4523x 0.9988 5.4264 134.930 A:B = 10:1 y = 3.8144 + 1.3747x 0.9923 7.2846 131.423 A:B = 20:1 y = 3.7629 + 1.3823x 0.9996 7.8519 125.402 A:B = 30:1 y = 3.8044 + 1.3270x 0.9966 7.9615 124.939

[0304] The experimental results (see Table 18) show that the compound of formula I mixed with tetradifon in the range of 1:36 to 24:1 has a good synergistic effect on the nymphs of Tetranychus cinnabarinus; when the mass ratio of the two is 1:12 to 24:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0305] Table 18 Results of Indoor Activity Assay of Compound I and Tetrachlor against Tetracarpus cinnabarin Nymphs

[0306] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.8387 + 1.1531x 0.9935 10.1651 / Tetradamine (B) y = 3.7261 + 1.6499x 0.9897 5.9166 / A:B = 1:48 y = 3.8949 + 1.5831x 0.9983 4.9898 119.594 A:B = 1:36 y = 3.9947 + 1.4863x 0.9980 4.7469 126.065 A:B = 1:12 y = 4.0490 + 1.4614x 0.9996 4.4744 136.625 A:B = 1:6 y = 4.0710 + 1.4579x 0.9999 4.3375 145.067 A:B = 1:3 y = 4.0515 + 1.4960x 0.9996 4.3054 153.457 A:B = 1:1 y = 4.0012 + 1.5094x 0.9969 4.5891 162.988 A:B = 3:1 y = 3.8719 + 1.5235x 0.9980 5.5014 156.651 A:B = 6:1 y = 3.9503 + 1.3320x 0.9946 6.1387 150.184 A:B = 12:1 y = 3.8172 + 1.4067x 0.9851 6.9316 138.972 A:B = 24:1 y = 3.8097 + 1.3510x 0.9925 7.6004 130.010 A:B = 48:1 y = 3.8071 + 1.2886x 0.9888 8.4285 118.862

[0307] The experimental results (see Table 19) show that the compound of formula I mixed with butyl urea in the range of 1:40 to 35:1 has a good synergistic effect on the nymphs of Tetranychus cinnabarinus; when the mass ratio of the two is 1:30 to 24:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0308] Table 19 Results of Indoor Activity Assays of Compound I Mixed with Butylephrine on Tetranychus cinnabarinus Nymphs

[0309] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.8387 + 1.1531x 0.9935 10.1651 / Butyl ether urea (B) y = 3.5682 + 1.7667x 0.9996 6.4627 / A:B = 1:40 y = 3.9492 + 1.4481x 0.9978 5.3164 122.651 A:B = 1:30 y = 3.9733 + 1.4734x 0.9959 4.9753 131.440 A:B = 1:15 y = 4.0853 + 1.3975x 0.9960 4.5136 146.518 A:B = 1:5 y = 4.0943 + 1.4052x 0.9997 4.4114 155.968 A:B = 2:3 y = 4.2013 + 1.2702x 0.9937 4.2542 177.820 A:B = 3:2 y = 4.0748 + 1.4065x 0.9977 4.5479 181.842 A:B = 7:1 y = 4.0158 + 1.3082x 0.9969 5.6533 167.792 A:B = 14:1 y = 3.7401 + 1.5654x 0.9991 6.3807 153.449 A:B = 24:1 y = 3.9057 + 1.2624x 0.9945 7.3591 135.035 A:B = 35:1 y = 3.9274 + 1.1940x 0.9990 7.7625 128.900 A:B = 42:1 y = 3.6771 + 1.3976x 0.9905 8.8421 113.451

[0310] The experimental results (see Table 20) show that the compound of formula I mixed with etoxazole in the range of 1:15 to 55:1 has a good synergistic effect on Tetranychus cinnabarinus eggs; when the mass ratio of the two is 1:10 to 45:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0311] Table 20 Results of Indoor Activity Assay for Tetranychus cinnabarinus Eggs with Compound I Mixed with Etoxazole

[0312] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.0105 + 1.4637x 0.9954 22.8673 / Ethoxydazole (B) y = 5.1651 + 1.5971x 0.9924 0.7882 / A:B = 1:25 y = 5.1774 + 1.4521x 0.9981 0.7548 108.452 A:B = 1:15 y = 5.2617 + 1.4235x 0.9991 0.6548 128.103 A:B = 1:10 y = 5.3110 + 1.4650x 0.9992 0.6134 140.861 A:B = 1:5 y = 5.3239 + 1.5342x 0.9984 0.6150 152.742 A:B = 5:1 y = 4.4047 + 1.5348x 0.9981 2.4427 165.144 A:B = 10:1 y = 3.9909 + 1.6104x 0.9941 4.2329 152.328 A:B = 15:1 y = 3.8788 + 1.5022x 0.9941 5.5760 149.087 A:B = 25:1 y = 3.7239 + 1.4504x 0.9967 7.5826 145.171 A:B = 35:1 y = 3.9571 + 1.0713x 0.9907 9.4074 136.706 A:B = 45:1 y = 3.6723 + 1.2840x 0.9969 10.8145 131.421 A:B = 55:1 y = 3.6273 + 1.2455x 0.9988 12.6513 120.483

[0313] The experimental results (see Table 21) show that the compound of formula I mixed with thiamethoxam in the range of 1:25 to 61:1 has a good synergistic effect on Tetranychus cinnabarinus eggs; when the mass ratio of the two is 1:15 to 50:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0314] Table 21 Results of the indoor bioactivity assay of compound I mixed with thiamethoxam and Tetranychus cinnabarin eggs.

[0315] Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg / L)]]> Cotoxicity coefficient Compound (A) of Formula I y = 3.0105 + 1.4637x 0.9954 22.8673 / Thiamethoxam (A) y = 5.4579 + 1.7904x 0.9942 0.5549 / A:B = 1:25 y = 5.5198 + 1.4985x 0.9990 0.4499 128.148 A:B = 1:15 y = 5.5576 + 1.5799x 0.9938 0.4437 133.184 A:B = 1:6 y=5.4775+1.4718x 0.9966 0.4738 136.086 A:B=1:2 y=5.3770+1.4317x 0.9949 0.5454 150.783 A:B=2:1 y=4.9816+1.4992x 0.9961 1.0287 154.335 A:B=12:1 y=4.1460+1.5826x 0.9949 3.4645 161.260 A:B=24:1 y=3.9532+1.4317x 0.9992 5.3847 162.810 A:B=33:1 y=3.8801+1.4291x 0.9996 6.0760 172.431 A:B=48:1 y=3.8227+1.3007x 0.9919 8.0369 156.282 A:B=50:1 y=3.6928+1.3241x 0.9983 9.7114 131.662 A:B=61:1 y=3.6577+1.2965x 0.9975 10.8464 127.888

[0316] The experimental results (see Table 22) show that the compound of formula I mixed with spirotetramat in the range of 1:50 to 50:1 has a good synergistic effect on Tetranychus cinnabarinus eggs; when the mass ratio of the two is 1:10 to 50:1, the co-toxicity coefficient is greater than 130, and the synergistic effect is obvious.

[0317] Table 22 Results of the indoor bioactivity assay of compound I mixed with spirotetramat and Tetranychus cinnabarin eggs.

[0318]

[0319]

[0320] Using the same research process as described above, it was found that, in addition to having a good control effect on Tetranychus carmineus, the compound of Formula I, when properly mixed with the acaricides mentioned above, also has a good control effect on Tetranychus dichotoma, Tetranychus truncatus, and Tetranychus citrusus.

[0321] Field efficacy trials:

[0322] Example 2: Field efficacy test of different acaricide compositions against bean spider mites

[0323] The experiment was conducted in a green bean field in a greenhouse in Xinjiadian Village, Daliutun Town, Xinmin City, Shenyang. The experimental plot was well-managed, the green bean variety was Yunfeng, and the beans showed uniform growth. All experimental plots were cultivated under identical conditions. The experiment used a randomized block design, with each treatment replicated four times. Each experimental plot was 30 m². 2 The application time is when the green beans have 4-5 true leaves. The spider mites are a mixed population of Carmine Spider Mite, Two-spotted Spider Mite, and Truncate Spider Mite. When applying the pesticide, use a sprayer to spray the entire green bean seedling to ensure that both sides of the leaves are evenly covered with the pesticide. A total of 1 application is required.

[0324] During the survey, 20 leaves were taken from each plot, and the number of surviving mites and nymphs was counted 3 days and 14 days after the application of the pesticide.

[0325] Methods for calculating drug efficacy:

[0326]

[0327] Table 23 Results of field efficacy trials of different acaricide compositions against spider mites.

[0328]

[0329]

[0330] The field efficacy results are shown in the above examples. When compound I is rationally combined with various pesticides, the dosage of pesticides can be reduced and the control effect on mites can be improved.

[0331] Example 3: Field efficacy test of different acaricide compositions against citrus red spider mites

[0332] The experimental site was set up in a citrus orchard in Matou Village, Tanxia Town, Lingchuan County, Guangxi Zhuang Autonomous Region. The soil was alluvial mud. The water and fertilizer management in the experimental site was moderate to high. The cultivation management of all experimental plots was relatively uniform and consistent, which was in line with local scientific agricultural practices.

[0333] Experimental target and crop: The experimental crop was citrus (Satsuma mandarin), and the experimental target was citrus red spider mite.

[0334] Experimental Design: The experiment consisted of 28 treatments, with each treatment replicated 4 times. The experimental plots were arranged in a randomized block design, with each plot containing 2 fruit trees.

[0335] Application time and method: The experiment was conducted once on September 13, 2021. The application was carried out using a backpack electric sprayer for conventional spraying. During application, the pesticide was evenly sprayed on both sides of the leaves, ensuring that the pesticide solution was suspended without dripping.

[0336] Experimental survey: Surveys were conducted 3, 7, and 14 days after pesticide application. Two trees were surveyed in each plot. Tender shoots were marked in five directions (east, south, west, north, and center) on each tree, and two leaves were surveyed in each direction. During the survey, the leaves were observed directly using a handheld magnifying glass, and the number of live mites on both sides of the leaves was counted. A total of 20 leaves were surveyed in each plot to count the number of live mites.

[0337] Methods for calculating drug efficacy:

[0338]

[0339] Results of field efficacy trials:

[0340]

[0341]

[0342] The results of indoor biotoxicity tests and field efficacy trials show that the acaricidal composition of the present invention has a good control effect on a variety of harmful mites and can effectively control the growth of harmful mite populations.

[0343] During the application period, irregular observations were conducted, and no adverse effects of the formulations on crop growth were found. No phytotoxic symptoms were observed, and the crops in each treatment were in good condition after application.

[0344] It should be understood that the above embodiments are merely some embodiments of the present invention, provided only to better understand the embodiments of the present invention, and are not all embodiments of the present invention. In practical applications, by adjusting the content of each component and the composition of the components in the present invention, different and numerous embodiments can be obtained, all of which are within the scope of the present invention.

[0345] The embodiments of the present invention have been described above. However, the present invention is not limited to the above embodiments. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A mite-killing composition, characterized in that, The acaricide composition comprises active ingredient A and active ingredient B, wherein active ingredient A is a compound represented by formula I: (I) The active ingredient B is selected from antibiotic acaricides: abamectin, methyl abamectin benzoate; the active ingredient B is abamectin, and the mass ratio of the active ingredient A to the active ingredient B is 1:10~80:1; the active ingredient B is methyl abamectin benzoate, and the mass ratio of the active ingredient A to the active ingredient B is 1:15~60:

1.

2. The acaricide composition according to claim 1, characterized in that, The active ingredient B is avermectin, and the mass ratio of active ingredient A to active ingredient B is 1:5 to 70:1; the active ingredient B is emamectin benzoate, and the mass ratio of active ingredient A to active ingredient B is 1:10 to 50:

1.

3. The acaricide composition according to claim 1, characterized in that, The active ingredient B is avermectin, and the mass ratio of active ingredient A to active ingredient B is 1:10, 1:5, 1:1, 10:1, 20:1, 30:1, 40:1, 50:1, 60:1, 70:1, or 80:1; the active ingredient B is emamectin benzoate, and the mass ratio of active ingredient A to active ingredient B is 1:15, 1:10, 1:5, 1:1, 5:1, 10:1, 20:1, 30:1, 40:1, 50:1, or 60:

1.

4. The acaricide composition according to claim 1, characterized in that, The total weight of the acaricide composition is 100 wt%, and the total weight of active ingredient A and active ingredient B accounts for 0.5% to 90% of the total weight of the acaricide composition.

5. The acaricide composition according to claim 4, characterized in that, The total weight of the acaricide composition is 100 wt%, and the total weight of active ingredient A and active ingredient B accounts for 2% to 80% of the total weight of the acaricide composition.

6. The acaricide composition according to claim 1, characterized in that, The acaricide composition is prepared into an agriculturally acceptable formulation, wherein the formulation is a liquid or solid formulation; the liquid formulation is selected from soluble concentrates, emulsifiable concentrates, water-in-oil emulsions, microemulsions, dispersible oil suspensions or suspensions, and the solid formulation is selected from powders, granules, wettable powders or water-dispersible granules.

7. The use of the acaricidal composition according to any one of claims 1-6 for the control of crop mites, characterized in that, The harmful mite mentioned is the carmine spider mite.

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