High-shear mixing device for preparing atorvastatin calcium

Abstract

The invention relates to the technical field of mixing equipment, and particularly discloses a high-shear mixing device for preparing atorvastatin calcium, the high-shear mixing device comprises an outer silo, an inner silo, a mixing mechanism and a sliding mechanism, the outer silo comprises an outer silo body and a discharge valve communicated with a cavity, the inner silo is provided with a mixing cavity, the inner silo is coaxially arranged in the outer silo body, and the mixing mechanism is arranged in the outer silo body. The top cover covers the top surface of the inner silo, and a protective cover is arranged on the side wall, close to the mixing cavity, of the top cover in an inverted mode. The mixing mechanism comprises a driving motor arranged on the outer surface of the top cover, a rotating shaft arranged in the axis direction of the mixing chamber, and one end of the rotating shaft sequentially penetrates through the protective cover and the top cover to be in transmission connection with the driving motor, impellers are arranged on the rotating shaft at intervals, a plurality of vertical rods are distributed around the rotating shaft, and the two ends of each vertical rod extend to be connected with the inner wall of the top cover and the bottom wall of the inner silo correspondingly; the two ends of the backflow pipeline are connected with the mixing cavity and the bottom of the outer silo respectively, materials are fully mixed, and meanwhile the mixing efficiency of the materials is improved.

Description

Technical Field

[0001] The present application relates to the technical field of mixing equipment, and in particular to a high shear mixing device for preparing atorvastatin calcium. Background Art

[0002] For atorvastatin calcium tablets, in a preparation process, atorvastatin calcium needs to be mixed with excipients such as lactose, microcrystalline cellulose, etc. The mixing equipment in the related art achieves mixing of the raw materials and excipients by fully adding the raw materials and excipients into the equipment and driving the rotating shaft with stirring blades to rotate. However, in order to more fully mix the raw materials and excipients, the rotating shaft is often set in the middle area of ​​the mixing chamber. In this way, under the influence of gravity and centrifugal force, some raw materials and excipients are easily thrown to the side walls and bottom of the mixing chamber and gathered. These materials cannot be fully stirred and mixed, resulting in uneven material mixing and low mixing efficiency. Summary of the Invention

[0003] The present application aims to propose a high shear mixing device for the preparation of atorvastatin calcium, so as to at least solve the problem in the prior art that the raw materials and auxiliary materials accumulated on the side walls and bottom of the mixing chamber of the powder mixing equipment cannot be fully mixed, resulting in uneven material mixing and low mixing efficiency.

[0004] In order to achieve the above-mentioned object, the present invention provides a high shear mixing device for preparing atorvastatin calcium, comprising: an outer silo, the outer silo comprising an outer barrel body and a discharge valve in communication with the cavity; An inner silo having a mixing chamber, the inner silo being coaxially disposed within the outer barrel; A top cover is provided on the top surface of the inner silo, and a protective cover is provided upside down on the top cover near one side wall of the mixing chamber; The mixing mechanism includes a driving motor arranged on the outer surface of the top cover, a rotating shaft distributed along the axial direction of the mixing chamber and one end of which passes through the protective cover and the top cover in sequence and is transmission-connected to the driving motor, a plurality of impellers arranged at intervals on the rotating shaft, and a plurality of vertical rods arranged at intervals around the rotating shaft, wherein the two ends of the vertical rods extend respectively to be connected to the inner wall of the top cover and the bottom wall of the inner silo, and the vertical rods are constructed to cooperate with the impeller to collide with the premixed material in the central area of ​​the mixing chamber to stir during mixing.

[0005] In some embodiments, a first cavity and a second cavity are formed between the outer wall of the inner silo and the inner wall of the outer silo, the first cavity is between the outer wall of the bottom end of the inner silo and the inner wall of the bottom end of the outer silo, and the second cavity is between the outer wall of the inner silo and the inner wall of the outer silo, wherein the first cavity is configured to temporarily store preliminarily mixed materials, and the second cavity is configured to accommodate part of the transmission components, and the bottom wall of the inner silo is radially provided with a plurality of first through grooves connecting the first cavity and the mixing chamber.

[0006] In some embodiments, the mixing mechanism also includes a gear plate, a first transmission rod, a driven roller and a conveyor belt. The gear plate is arranged in the protective cover and is connected to the rotating shaft. One end of the first transmission rod extends into the protective cover and is provided with a bevel gear engaged with the gear plate, and the other end extends to the second cavity and is transmission-connected to one end of the conveyor belt. The driven roller is arranged in the first through groove, and one end extends to the second cavity and is transmission-connected to the conveyor belt.

[0007] In some embodiments, both ends of the first through groove extend close to the rotating shaft and the side wall of the inner silo, respectively, wherein, when the driven roller rotates, the outer contour surface of the driven roller at least partially intermittently protrudes from the first through groove toward the mixing chamber, and the driven roller intermittently isolates the communication between the first cavity and the mixing chamber by cooperating with the first through groove.

[0008] In some embodiments, a partition and a bottom plate connected to the partition are provided in the second cavity, the partitions are spaced apart on both sides of the conveyor belt, and both ends of the bottom plate are respectively connected to the two partitions to isolate the transmission area of ​​the conveyor belt from the first cavity.

[0009] In some embodiments, the device also includes a sliding mechanism, which includes an intermittent disk, a second transmission rod, a strip plate and a cover plate with a material storage cavity. The intermittent disk is arranged on the rotating shaft close to the surface of the protective cover, and the cover plate is snapped onto the inner wall of the outer silo and the opposite end extends into the mixing chamber. One end of the second transmission rod sequentially penetrates the outer silo and the inner silo and extends to the intermittent disk, and the other end penetrates the outer silo and extends to the material storage cavity and is connected to the strip plate, wherein the cover plate is provided with a fourth through hole connecting the mixing chamber and the storage cavity.

[0010] In some embodiments, the circumferential surface of the intermittent disk is provided with raised portions at intervals, the surface of the second transmission rod is provided with a stopper and an elastic member connected to the stopper and the outer silo at both ends respectively, wherein the elastic member is constructed to cooperate with the raised portion to enable the second transmission rod to move periodically along the radial direction of the mixing chamber.

[0011] In some embodiments, a plug rod is provided at intervals on the surface of the strip plate facing the fourth through hole, and when the second transmission rod moves periodically, the plug rod intermittently blocks the fourth through hole.

[0012] In some embodiments, a notch is provided at the bottom of the cover plate, and the notch connects the material receiving cavity and the first cavity.

[0013] In some embodiments, the device further includes a return pipe, one end of which is connected to the first cavity, and the other end passes through the top cover and extends into the mixing chamber, wherein a Venturi powder valve is provided at one end of the return pipe near the first cavity, and a bending portion is provided at the other end, and the bending portion is constructed so that the discharge port of the return pipe faces the impeller.

[0014] Compared with the prior art, the technical solutions provided by the above embodiments of the present application include at least the following beneficial effects or advantages: 1) By arranging a mixing mechanism in the mixing chamber, a plurality of impellers are arranged at intervals on the rotating shaft of the mixing mechanism, and a plurality of vertical rods are arranged circumferentially of the rotating shaft. The intervals between the multiple impellers increase the stirring area in the silo. In this way, more effective mixing of the premixed materials gathered at the bottom is achieved. The vertical rods cooperate with the impellers to collide with the premixed materials stirred in the central area of ​​the mixing chamber. On the one hand, the premixed materials can be broken up to avoid agglomeration. On the other hand, the collided materials are further mixed with the stirred materials by the reaction force, thereby improving the mixing efficiency of the materials.

[0015] 2) A first cavity and a second cavity are formed between the outer silo and the inner silo, and a sliding mechanism is provided on the side wall of the inner silo. The sliding mechanism can intermittently control the connection between the inner wall area of ​​the mixing chamber and the first cavity, so that the premixed material thrown to the side wall of the mixing chamber is intermittently transferred to the first cavity. Then, through the setting of the return pipe, the return pipe transfers the material in the first cavity to the top of the mixing chamber, so that the unevenly mixed materials are stirred and mixed again. The operation of the sliding mechanism is synchronized with the mixing mechanism to achieve sufficient mixing of the materials and improve the mixing efficiency of the materials.

[0016] 3) A first through groove connected to the first cavity is opened at the bottom of the inner silo, and a driven roller is arranged in the first through groove along the length direction of the groove. When the driven roller rotates, at least a part of the outer contour surface of the driven roller intermittently protrudes from the first through groove toward the mixing chamber, and the driven roller cooperates with the first through groove to intermittently cut off the connection between the first cavity and the mixing chamber. In this way, the arrangement of the driven roller can intermittently transfer the premixed material that falls to the bottom of the mixing chamber due to gravity to the first cavity, and then transfer it to the top of the mixing chamber through the reflux pipe for sufficient mixing. In addition, by arranging the surface of the driven roller into an irregular shape, the material can be further fully mixed while controlling the transfer of the premixed material.

[0017] Additional aspects and advantages of the present application will be given in part in the description below, and in part will become obvious from the description below, or will be learned through practice of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0019] Figure 1 is a schematic structural diagram of a mixing device according to an embodiment of the present application; Figure 2 is a front view of a mixing device according to an embodiment of the present application; Figure 3 is based on Figure 2 Cross-sectional view along AA direction; Figure 4 is based on Figure 2 Cross-sectional view along the BB direction; Figure 5 is a top view of a mixing device according to an embodiment of the present application; Figure 6 is based on Figure 5 Cross-sectional view along CC direction; Figure 7 is a structural diagram of a mixing mechanism according to an embodiment of the present application; Figure 8 is a partial cross-sectional view of a first through groove according to an embodiment of the present application; Figure 9 is a structural schematic diagram of a sliding mechanism according to an embodiment of the present application; Figure 10 is a partial structural diagram of a sliding mechanism according to an embodiment of the present application; Figure 112 is a top view of a sliding mechanism according to an embodiment of the present application.

[0020] Reference numerals: 10. Mixing device; 100, outer silo; 110, outer cylinder body; 111, support leg; 112, discharge valve; 113, first through hole; 114, second through hole; 115, first limiting hole; 120, first cavity; 130, second cavity; 140, partition; 141, bottom plate; 150, return pipe; 151, Venturi powder valve; 152, bending portion; 200, inner silo; 210, mixing chamber; 230, first through slot; 240, third through hole; 250, second through slot; 300, top cover; 310, feed valve; 320, protective cover; 321, second limiting hole; 400, mixing mechanism; 410, drive motor; 420, rotating shaft; 430, impeller; 440, vertical rod; 441, third limiting hole; 450, gear plate; 460, first transmission rod; 461, bevel gear; 462, first pulley; 470, driven roller; 471, second pulley; 480, conveyor belt; 500, sliding mechanism; 510, intermittent disk; 511, protrusion; 520, second transmission rod; 521, stopper; 522, elastic member; 530, strip plate; 531, plug rod; 532, limit rod; 540, cover plate; 541, material chamber; 542, fourth through hole; 543, notch. DETAILED DESCRIPTION

[0021] The embodiments of the present application are described in detail below. The embodiments described with reference to the accompanying drawings are exemplary. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0022] It should be noted that when an element is referred to as being “fixed to” another element, it may be directly on the other element or there may be an intermediate element. When an element is referred to as being “connected to” another element, it may be directly connected to the other element or there may be an intermediate element.

[0023] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this application pertains. The terms used herein in the specification of this application are for the purpose of describing specific embodiments only and are not intended to limit this application. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0024] See also Figures 1 to 4The present embodiment provides a high shear mixing device 10 for preparing atorvastatin calcium. The mixing device 10 may include an outer silo 100, an inner silo 200, a top cover 300, a mixing mechanism 400 and a sliding mechanism 500. The outer silo 100 includes an outer cylinder body 110. An inner cavity is provided in the outer cylinder body 110. The inner silo 200 is coaxially arranged in the inner cavity. A space gap is reserved between the outer wall of the inner silo 200 and the inner wall of the outer cylinder body 110. The outer cylinder body 110 may be shaped as a cylindrical cylinder with a conical bottom. Support legs 111 and a discharge valve 112 may be provided on the outer surface of the bottom of the outer cylinder body 110. The discharge valve 112 is connected to the outer cylinder body 110. The inner cavity of the cylinder 110, the top part of the inner silo 200 extends to the outside of the outer silo 100 and is sealed with the top cover 300, the driving part of the mixing mechanism 400 is arranged on the top cover 300 and the stirring part is arranged in the chamber of the inner silo 200, the stirring part is connected with the driving part by transmission, the sliding mechanism 500 is distributed between the outer silo 100 and the inner silo 200, and shares the same driving element with the mixing mechanism 400. Through the arrangement of the mixing mechanism 400 and the sliding mechanism 500, during the mixing process, the materials on the side walls and bottom of the mixing chamber 210 can be further transported to the chamber of the inner silo 200 for mixing, thereby achieving full mixing of the premixed materials and improving the mixing efficiency.

[0025] See also Figures 3 to 6 The inner silo 200 is provided with a mixing chamber 210, which is sealed by a top cover 300. A feed valve 310 connected to the mixing chamber 210 is provided on the top surface of the top cover 300. A first cavity 120 and a second cavity 130 are formed between the outer wall of the inner silo 200 and the inner wall of the outer silo 100. The first cavity 120 is between the outer wall of the bottom end of the inner silo 200 and the inner wall of the bottom end of the outer silo 100, and the second cavity 130 is between the outer wall of the inner silo 200 and the inner wall of the outer silo 100. The first cavity 120 is configured to temporarily store preliminarily mixed materials, and the second cavity 130 is configured to accommodate part of the transmission components.

[0026] In some embodiments, the mixing mechanism 400 includes a drive motor 410, a rotating shaft 420, an impeller 430 and a vertical rod 440. The drive motor 410 is arranged on the outer surface of the top cover 300, the rotating shaft 420 is distributed along the axial direction of the mixing chamber 210 and one end passes through the top cover 300 in sequence and is transmission-connected to the drive motor 410. A plurality of impellers 430 are arranged at intervals on the rotating shaft 420, and a plurality of vertical rods 440 are distributed around the rotating shaft 420, wherein the two ends of the vertical rod 440 extend respectively to connect with the inner wall of the top cover 300 and the bottom wall of the inner silo 200, and the vertical rod 440 is constructed to cooperate with the impeller 430 to collide with the premixed material stirred in the central area of ​​the mixing chamber 210 during mixing.

[0027] Optionally, a protective cover 320 is provided at the rotational connection between the rotating shaft 420 and the top cover 300, and the protective cover 320 is inverted on the inner surface of the top cover 300. One end of the rotating shaft 420 is rotationally connected to the inner surface of the bottom of the mixing chamber 210, and the other end passes through the top cover 300 and the protective cover 320 and is transmission-connected to the output shaft of the drive motor 410. A plurality of impellers 430 are arranged at intervals on the surface of the rotating shaft 420 in the mixing chamber 210. The number of impellers 430 can be four, five or six. The plurality of vertical rods 440 arranged axially on the impeller 430 can be four, three or two arranged at intervals, and the specific selection can be made according to actual needs.

[0028] With such an arrangement, the multiple impellers 430 are arranged at intervals, which increases the stirring area in the silo, and can fully mix the premixed materials in the mixing chamber 210, especially for the premixed materials gathered at the bottom, so as to achieve more effective mixing. The vertical rod 440 cooperates with the impeller 430 to collide with the premixed materials stirred in the central area of ​​the mixing chamber 210. On the one hand, the premixed materials can be broken up to avoid agglomeration. On the other hand, the collided materials are further mixed with the stirred materials by the reaction force, thereby improving the mixing efficiency of the materials.

[0029] Combined diagram Figures 4 to 7 The bottom wall of the inner silo 200 is radially provided with a plurality of first through grooves 230 connecting the first cavity 120 and the mixing chamber 210, and a third through hole 240 is opened through the side wall of the inner silo 200, and the third through hole 240 connects the second cavity 130 and the mixing chamber 210. The mixing mechanism 400 also includes a gear plate 450, a first transmission rod 460, a driven roller 470 and a conveyor belt 480. The gear plate 450 is arranged in the protective cover 320 and is connected to the rotating shaft 420. One end of the first transmission rod 460 extends into the protective cover 320 and is provided with a bevel gear 461 meshing with the gear plate 450, and the other end extends to the second cavity 130 and is transmission-connected to one end of the conveyor belt 480. The driven roller 470 is arranged in the first through groove 230, and one end extends to the second cavity 130 and is transmission-connected to the other end of the conveyor belt 480.

[0030] In this way, through the setting of the gear plate 450, the synchronous rotation of multiple driven rollers 470 based on one driving element is achieved, so that the mixing space of the mixing chamber 210 is maximized, and the first cavity 120 and the second cavity 130 are formed between the outer silo 100 and the inner silo 200. A sliding mechanism 500 is set on the side wall of the inner silo 200. The sliding mechanism 500 can intermittently control the connection between the inner wall area of ​​the mixing chamber 210 and the first cavity 120, so that the premixed material thrown to the side wall of the mixing chamber 210 is intermittently transferred to the first cavity 120, and then through the setting of the return pipe 150, the return pipe 150 transfers the material in the first cavity 120 to the top of the mixing chamber 210, so that the unevenly mixed material is stirred and mixed again. The operation of the sliding mechanism 500 is synchronized with the mixing mechanism 400 to achieve sufficient mixing of the material and improve the mixing efficiency of the material.

[0031] Optionally, the first transmission rod 460 extends into the protective cover 320 through a second limiting hole 321 provided on the protective cover 320, the first through grooves 230 are distributed radially along the mixing chamber 210, and all the first through grooves 230 are arranged to diverge outward from the central axis of the mixing chamber 210. At the same time, a second limiting hole 321 is provided on the protective cover 320, one end of the driven roller 470 extends through the second limiting hole 321 to the second cavity 130 where a second pulley 471 is provided, and the other end of the first transmission rod 460 extends through and extends to the second cavity 130 where a first pulley 462 is provided, and a transmission connection is realized between the first pulley 462 and the second pulley 471 through a conveyor belt 480.

[0032] In this way, the setting of the protective cover 320 can prevent the premixed material from entering the connection between the first transmission rod 460 and the gear plate 450, thereby protecting the transmission stability of the connection. By setting the gear plate 450 near the top of the rotating shaft 420 to control the driven roller 470 at the bottom of the inner silo 200, on the one hand, considering that the closer to the drive motor 410, the more stable the driving force output on the rotating shaft 420, on the other hand, the mixing space of the mixing chamber 210 is maximized. At the same time, the transmission mechanism is set in the second cavity 130, and the mixing space of the mixing chamber 210 is maximized while ensuring the stability of power transmission.

[0033] See also Figure 8The shape of the driven roller 250 can be a semicircular cross-section set on its surface along the rotating axis, and of course it can also be a tri-circular square. When the driven roller 250 rotates, the outer contour surface of the driven roller 250 away from the rotating axis at least partially intermittently protrudes from the first through groove 230 toward the mixing chamber 210, and the driven roller 250 cooperates with the first through groove 230 to intermittently block the connection between the first cavity 120 and the mixing chamber 210. In this way, on the one hand, for the protruding part of the driven roller 250, the incompletely mixed materials at the bottom of the mixing chamber 210 can be further mixed, and on the other hand, it is convenient to intermittently transfer the incompletely mixed materials at the bottom of the mixing chamber 210 to the first cavity 120.

[0034] Optionally, four first through grooves 230 can be arranged at intervals, and the four first through grooves 230 are distributed in a cross shape at the bottom of the mixing chamber 210. The two ends of the first through grooves 230 extend to the vicinity of the rotating shaft 420 and the side wall of the inner silo 200 respectively, and a driven roller 250 is arranged in each first through groove 230. That is, it can be understood that the number of first through grooves 230, driven rollers 250, conveyor belts 480 and first transmission rods 460 is the same. In this way, it is convenient to drop more insufficiently mixed materials accumulated at the bottom of the mixing chamber 210 into the first cavity 120.

[0035] Combine Figure 2 and Figure 6 For the material falling into the first cavity 120, the device is further provided with a return pipe 150. The return pipe 150 is arranged outside the outer silo 100, and one end is connected to the first cavity 120, and the other end passes through the top cover 300 and extends to the mixing chamber 210. Specifically, one end of the return pipe 150 is connected to the first cavity 120, and the other end passes through the top cover 300 and extends into the mixing chamber 210. The return pipe 150 is provided with a Venturi powder valve 151 at one end close to the first cavity 120, and a bending portion 152 at the other end. The bending portion 152 is constructed to make the discharge port of the return pipe 150 face the impeller 430.

[0036] Optionally, the Venturi powder valve 151 can be obtained from the existing technology, and it can also include an air source device connected to the Venturi powder valve 151. The setting of the Venturi powder valve 151 can realize the transfer of powdered material from the first cavity 120 to the mixing chamber 210. The specific structure and related working principle of the Venturi powder valve 151 are not elaborated here.

[0037] In this way, the setting of the return pipe 150 transfers the unevenly mixed materials in the first cavity 120 to the mixing chamber 210 for further thorough mixing. By setting a bending portion 152 at one end of the return pipe 150 in the mixing chamber 210, the insufficiently mixed materials are transferred to the impeller 430 to achieve a better mixing effect.

[0038] Combine Figure 4 and Figure 6 A feed valve 310 connected to the mixing chamber 210 can also be provided on the top cover 300. The feed valve 310 is used to add the raw materials to be mixed into the mixing chamber 210. A partition 140 and a bottom plate 141 connected to the partition 140 are provided in the second cavity 130. The partitions 140 are arranged at intervals on both sides of the conveyor belt 480. The two ends of the bottom plate 141 are respectively connected to the two partitions 140 to isolate the transmission area of ​​the conveyor belt 480 from the first cavity 120. The partition 140, the bottom plate 141, the outer wall of the inner silo 200 and the inner wall of the outer cylinder body 110 jointly isolate the transmission area of ​​the conveyor belt 480 from the first cavity 120, so as to prevent the material in the first cavity 120 from interfering with the transmission of the conveyor belt 480.

[0039] See also Figure 3 、 Figure 4 、 Figures 9 to 11 , as for the sliding mechanism 500, it is used to transfer the material in the mixing chamber 210 near the side wall area of ​​the inner silo 200 to the first cavity 120. The sliding mechanism 500 may include an intermittent disk 510, a second transmission rod 520, a strip plate 530 and a cover plate 540 with a material receiving cavity 541. The intermittent disk 510 is arranged on the rotating shaft 420 near the surface of the protective cover 320, the cover plate 540 is buckled on the inner wall of the outer silo 100 and the opposite end extends into the mixing chamber 210, one end of the second transmission rod 520 sequentially penetrates the outer silo 100 and the inner silo 200 and extends to the intermittent disk 510, and the other end penetrates the outer silo 100 and extends to the material receiving cavity 541 and is connected to the strip plate 530, wherein the cover plate 540 is provided with a fourth through hole 542 connecting the mixing chamber 210 and the receiving cavity 541.

[0040] In some embodiments, a first through hole 113, a second through hole 114 spaced apart from the first through hole 113, and first limiting holes 115 spaced apart on both sides of the second through hole 114 are provided on the surface of the outer cylinder body 110 near the top, the vertical rod 440 is provided with a third limiting hole 441, and the third limiting hole 441 is coaxially arranged with the first through hole 113. One end of the second transmission rod 520 passes through the third limiting hole 441 and the first through hole 113 in sequence to approach the intermittent disk 510, extends to the outside of the outer cylinder body 110 and passes through the second through hole 114 to connect the strip plate 530 in the second cavity 130. The strip plate 530 is located in the cavity formed by the cover plate 540 and the inner wall of the outer cylinder body 110.

[0041] Optionally, a second through slot 250 is provided on the side wall of the inner silo 200, and the second through slot 250 communicates with the mixing chamber 210 and the second cavity 130. The shape of the second through slot 250 matches the shape of the cover plate 540, wherein the cover plate 540 extends into the mixing chamber 210 through a portion of the surface of the second through slot 250, and the cover plate 540 has a material receiving cavity 541 formed by being surrounded by the outer silo 100, and the material receiving cavity 541 is communicated with the mixing chamber 210 through a fourth through hole 542, and a notch portion 543 is provided at the bottom of the cover plate 540, and the notch portion 543 forms the material receiving cavity 541. 541 is connected to the first cavity 120, and a limiting rod 532 is set on the side surface where the strip plate 530 is connected to the second transmission rod 520. The limiting rod 532 cooperates with the first limiting hole 115 to ensure the stability of the periodic reciprocating motion of the strip plate 530 in the cover plate 540. A plurality of plug rods 531 are set on the opposite surface of the strip plate 530 away from the limiting rod 532. The plurality of plug rods 531 are arranged at intervals and cooperate with the fourth through hole 542 of the cover plate 540. When the second transmission rod 520 moves periodically, the plug rod 531 intermittently blocks the fourth through hole 542.

[0042] In some embodiments, protrusions 511 are arranged at intervals on the circumferential surface of the intermittent disk 510, and a stopper 521 is provided on the surface of the second transmission rod 520, as well as an elastic member 522 connected to the stopper 521 and the outer silo 100 at both ends, wherein the elastic member 522 is constructed to cooperate with the protrusion 511 to enable the second transmission rod 520 to move periodically along the radial direction of the mixing chamber 210.

[0043] Optionally, the elastic member 522 can be a spring, a structure made of a highly elastic composite material, etc. The number of protrusions 511 can be set to be the same as the number of the second transmission rod 520, or it can be set to be different. It should be noted that when the number of protrusions 511 is set more, the frequency of the telescopic periodic motion of the second transmission rod 520 is higher. Therefore, it can be selectively designed according to actual needs. At the same time, the protrusion 511 can be a slope structure with two different inclinations or slopes, wherein, when the intermittent disk 510 rotates, the second transmission rod 520 slides from a slope with a lower inclination or slope to the outermost top of the protrusion 511, and then slides off from the protrusion 511, thereby realizing intermittent motion of the second transmission rod 520.

[0044] For example, combined Figure 9 and Figure 11Under normal circumstances at the beginning, the elastic member 522 is in a stretched state, thus ensuring that one end of the second transmission rod 520 contacts the circumferential surface of the intermittent disk 510. When the intermittent disk 510 rotates along the direction a, the protrusion 511 rotates until it contacts and squeezes the second transmission rod 520, causing the second transmission rod 520 to move in the direction b, which is the radial direction of the mixing chamber 210. The second transmission rod 520 drives the strip plate 530 to move away from the cover plate 540, so that the plug rod 531 is pulled out of the fourth through hole 542, so that the material in the mixing chamber 210 that is centrifugally accumulated on the side wall enters the material receiving chamber 541, and then falls from the material receiving chamber 541 into the first cavity 120 through the provided notch 543, and is then transferred to the central area of ​​the mixing chamber 210 through the reflux pipe 150 for further mixing.

[0045] In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation to the invention.

[0046] Throughout this specification, reference to terms such as "one embodiment," "some embodiments," "illustrative embodiments," "example," "specific example," or "some examples" means that a specific feature, structure, material, or characteristic described in conjunction with the embodiment or example is included in at least one embodiment or example of the present application. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example.

[0047] Obviously, the described embodiments are only some of the embodiments of the present application, rather than all of the embodiments. Mentioning "embodiment" in this article means that the specific features, structures or characteristics described in conjunction with the embodiment may be included in at least one embodiment of the present embodiment application. The appearance of this phrase in various positions in the specification does not necessarily mean that they are all the same embodiments, nor are they independent or alternative embodiments that are mutually exclusive with other embodiments. It can be understood explicitly and implicitly by those skilled in the art that the embodiments described herein can be combined with other embodiments. Based on the embodiments in this application, all other embodiments obtained by those of ordinary skill in the art without making creative work are within the scope of protection of this application.

[0048] Although the embodiments of the present application have been shown and described, those skilled in the art will appreciate that various changes, modifications, substitutions, and variations may be made to the embodiments without departing from the principles and intent of the present application, and that the scope of the present application is defined by the claims and their equivalents.

Claims

1. A high shear mixing device for preparing atorvastatin calcium, characterized in that: include: an outer silo, the outer silo comprising an outer barrel body and a discharge valve in communication with the cavity; An inner silo having a mixing chamber, the inner silo being coaxially disposed within the outer barrel; A top cover is provided on the top surface of the inner silo, and a protective cover is provided upside down on the top cover near one side wall of the mixing chamber; The mixing mechanism includes a driving motor arranged on the outer surface of the top cover, a rotating shaft distributed along the axial direction of the mixing chamber and one end of which passes through the protective cover and the top cover in sequence and is transmission-connected to the driving motor, a plurality of impellers arranged at intervals on the rotating shaft, and a plurality of vertical rods arranged at intervals around the rotating shaft, wherein the two ends of the vertical rods extend respectively to be connected to the inner wall of the top cover and the bottom wall of the inner silo, and the vertical rods are constructed to cooperate with the impeller to collide with the premixed material in the central area of ​​the mixing chamber to stir during mixing.

2. The high shear mixing device for preparing atorvastatin calcium according to claim 1, characterized in that: A first cavity and a second cavity are formed between the outer wall of the inner silo and the inner wall of the outer silo, the first cavity is between the outer wall of the bottom end of the inner silo and the inner wall of the bottom end of the outer silo, and the second cavity is between the outer wall of the inner silo and the inner wall of the outer silo, wherein the first cavity is configured to temporarily store preliminarily mixed materials, and the second cavity is configured to accommodate part of the transmission components, and the bottom wall of the inner silo is radially provided with a plurality of first through grooves connecting the first cavity and the mixing chamber.

3. The high shear mixing device for preparing atorvastatin calcium according to claim 2, characterized in that: The mixing mechanism also includes a gear plate, a first transmission rod, a driven roller and a conveyor belt. The gear plate is arranged in the protective cover and is connected to the rotating shaft. One end of the first transmission rod extends into the protective cover and is provided with a bevel gear engaged with the gear plate, and the other end extends to the second cavity and is connected to the conveyor belt. The driven roller is arranged in the first through groove, and one end extends to the second cavity and is connected to the conveyor belt.

4. The high shear mixing device for preparing atorvastatin calcium according to claim 3, characterized in that: The two ends of the first through groove extend respectively to the vicinity of the rotating shaft and the side wall of the inner silo, wherein, when the driven roller rotates, at least a portion of the outer contour surface of the driven roller intermittently protrudes from the first through groove toward the mixing chamber, and the driven roller intermittently blocks the communication between the first cavity and the mixing chamber by cooperating with the first through groove.

5. The high shear mixing device for preparing atorvastatin calcium according to claim 3, characterized in that: A partition and a bottom plate connected to the partition are provided in the second cavity. The partitions are spaced apart on both sides of the conveyor belt, and both ends of the bottom plate are respectively connected to the two partitions to isolate the transmission area of ​​the conveyor belt from the first cavity.

6. The high shear mixing device for preparing atorvastatin calcium according to claim 2, characterized in that: The device also includes a sliding mechanism, which includes an intermittent disk, a second transmission rod, a strip plate and a cover plate with a material storage cavity. The intermittent disk is arranged on the rotating shaft near the surface of the protective cover. The cover plate is buckled on the inner wall of the outer silo and the opposite end extends into the mixing chamber. One end of the second transmission rod sequentially penetrates the outer silo and the inner silo and extends to the intermittent disk, and the other end penetrates the outer silo and extends to the material storage cavity and is connected to the strip plate, wherein the cover plate is provided with a fourth through hole connecting the mixing chamber and the storage cavity.

7. The high shear mixing device for preparing atorvastatin calcium according to claim 6, characterized in that: The circumferential surface of the intermittent disk is provided with raised portions at intervals, and the surface of the second transmission rod is provided with a stopper and an elastic member whose two ends are respectively connected to the stopper and the outer silo, wherein the elastic member is constructed to cooperate with the raised portion to enable the second transmission rod to move periodically along the radial direction of the mixing chamber.

8. The high shear mixing device for preparing atorvastatin calcium according to claim 6, characterized in that: A plug rod is provided at intervals on the surface of the strip plate facing the fourth through hole. When the second transmission rod moves periodically, the plug rod intermittently blocks the fourth through hole.

9. The high shear mixing device for preparing atorvastatin calcium according to claim 6, characterized in that: A notch is provided at the bottom of the cover plate, and the notch communicates with the material receiving cavity and the first cavity.

10. The high shear mixing device for preparing atorvastatin calcium according to claim 2, characterized in that: The device also includes a return pipe, one end of which is connected to the first cavity, and the other end passes through the top cover and extends into the mixing chamber, wherein a Venturi powder valve is provided at one end of the return pipe close to the first cavity, and a bending portion is provided at the other end, and the bending portion is constructed to make the discharge port of the return pipe face the impeller.

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