Universal antiviral eyedrops and preparation method thereof

Abstract

The invention relates to the field of medicine, in particular to universal antiviral eyedrops and a preparation method thereof. The antiviral eyedrop comprises 5-19% by mass of sodium chloride and 95-81% by mass of pure water, and is a special advanced physiological sodium chloride water-soluble solution prepared by a specific method. The mechanism for preparing the antiviral eyedrops from sodium chloride is as follows: firstly, the content of sodium chloride in a sodium chloride water-soluble liquid is determined to be greater than or equal to 5% for the first time, and the eyedrops have a universal specific medicinal function of resisting eye disease viruses; and secondly, the tolerable safety limit value of the eyes of people to the sodium chloride content of the sodium chloride water-soluble liquid can reach 19% threshold value for the first time. According to the invention, the sodium chloride content ratio threshold value of the 5-19% sodium chloride water-soluble liquid with unified effectiveness and safety is set as a basic technical formula and standard for preparing the novel antiviral eye drops from sodium chloride. Meanwhile, the antiviral eyedrops are designed to be light and thick so as to be suitable for patients in primary clinical treatment.

Description

Technical Field

[0001] The present invention relates to the technical field of eye drops preparation, and in particular to universal antiviral eye drops and a preparation method thereof. Background Art

[0002] Currently, in the field of medical ophthalmology, eye diseases are primarily treated with eye drops. Eye drops containing antibiotics are used for targeted treatment of eye diseases caused by bacterial inflammation. However, for viral eye diseases, existing antiviral eye drops such as acyclovir eye drops, ganciclovir eye drops, ribavirin eye drops, and interferon eye drops can only target specific diseases.

[0003] Acyclovir eye drops are primarily used to treat herpes simplex keratitis and conjunctivitis. Ganciclovir eye drops are indicated for herpes simplex keratitis. Ribavirin eye drops can be used to treat a variety of viral infections, such as herpes simplex keratitis and epidemic hemorrhagic conjunctivitis. Interferon eye drops have broad-spectrum antiviral properties and are commonly used to treat viral corneal ulcers.

[0004] On the one hand, all four categories of antiviral eye drops have a certain probability of adverse reactions and restrict their use in certain populations. For example, caution should be exercised in those with allergic reactions and in pregnant and lactating women. Furthermore, each of these four categories of antiviral eye drops targets a specific type of virus, and their broad-spectrum antiviral effects are relatively poor.

[0005] Viral eye diseases are serious threats to human eye health. They are difficult to treat, prone to infection and recurrence, and in addition to causing pain to patients, can also cause permanent vision loss in severe cases. For example, viral damage to the cornea can leave irreversible scars, effectively leaving patients with lifelong vision impairment. Therefore, a universal antiviral eye drop and its preparation method are urgently needed. Summary of the Invention

[0006] In order to solve the problem that existing eye drops cannot universally treat viral eye diseases, the present invention provides a universal antiviral eye drops and a preparation method thereof, which are applicable to a wide range of people and have obvious antiviral efficacy.

[0007] The present invention provides a universal antiviral eye drops, which is achieved through the following technical solutions: A universal antiviral eye drop comprises at least 5-19 parts by mass of sodium chloride and 81-95 parts by mass of high-purity water, wherein the content of sodium chloride in the universal antiviral eye drop is 5-19wt%.

[0008] Preferably, the content of sodium chloride in the universal antiviral eye drops is 5-11 wt%.

[0009] Preferably, the content of sodium chloride in the universal antiviral eye drops is 11-19 wt %.

[0010] Preferably, the high-purity water complies with EW-I electronic grade water or EW-II electronic grade water specified in GB / T 11446.1-1997.

[0011] Preferably, the sodium chloride is any one of 4N grade, 5N grade and 6N grade.

[0012] The eye drops prepared by the present invention have few impurities, pure raw materials, little eye irritation, are applicable to a wide range of people, and can effectively eliminate viruses and treat eye diseases caused by viruses.

[0013] Preferably, the high-purity water includes EW-I electronic grade water or EW-II electronic grade water, and also includes terahertz water.

[0014] Further preferably, the terahertz water content in the universal antiviral eye drops is 500-2000 ppm.

[0015] Preferably, the universal antiviral eye drops are divided into low-concentration antiviral eye drops and high-concentration antiviral eye drops. The low-concentration antiviral eye drops are composed of 5-11wt% of sodium chloride, 500-2000ppm of terahertz water, and the remainder is EW-I electronic grade water or EW-II electronic grade water; the high-concentration antiviral eye drops are composed of 11-19wt% of sodium chloride, 500-2000ppm of terahertz water, and the remainder is EW-I electronic grade water or EW-II electronic grade water.

[0016] Preferably, the low-concentration antiviral eye drops are composed of 8-9wt% sodium chloride, 80-120ppm terahertz water, and the balance is EW-II electronic grade water; the high-concentration antiviral eye drops are composed of 15-16wt% sodium chloride, 80-120ppm terahertz water, and the balance is EW-II electronic grade water.

[0017] After using the dilute universal antiviral eye drops for 2 to 3 times, switch to concentrated universal antiviral eye drops, which contain 11-19wt% sodium chloride. This allows the patient's eyes to adapt to the higher concentration of special universal antiviral eye drops, thereby achieving better treatment results.

[0018] The present invention provides a method for preparing a universal antiviral eye drops, which is achieved through the following technical solutions: A method for preparing universal antiviral eye drops, comprising the following steps: Step 1: Place the glass reactor in an ISO Class 1 or ISO Class 5 cleanroom. Rinse the reactor multiple times with high-purity water. Then test the cleaning solution for resistivity, 1µm particle count, and total organic carbon. When the cleaning solution's resistivity is less than 14MΩ·cm (25°C), the 1µm particle count is less than 12 particles / mL, and the total organic carbon is less than 110µg / L, the glass reactor is rinsed and dried to remove any water vapor. Step 2: high-purity water is introduced into the glass reactor, and then 4N grade sodium chloride, 5N grade sodium chloride or 6N grade sodium chloride is added to the glass reactor. An ultrasonic oscillator is set up 0.1-0.5 cm from the bottom of the glass reactor. The frequency of the ultrasonic oscillator is 40-80kHz, the power is 600-1200W, the ultrasonic oscillation is performed for 15-30 minutes, and the mixture is allowed to stand for 0.5-24 hours. The universal antiviral eye drops are then filtered through a nanofiltration membrane and filled.

[0019] The eye drops prepared by the above-mentioned universal antiviral eye drops have few impurities, pure raw materials, minimal eye irritation, are suitable for a wide range of people, effectively eliminate viruses, and effectively treat eye diseases caused by viruses. In addition, the preparation method of the present invention is relatively simple, has low operational difficulty, and is easy to implement in large-scale chemical production configuration.

[0020] In summary, the present invention has the following advantages: 1. The eye drops of the present invention have few impurities, pure raw materials, little eye irritation, are suitable for a wide range of people, and can effectively eliminate viruses and treat eye diseases caused by viruses.

[0021] 2. The preparation method of the present invention is relatively simple, has low operational difficulty, and is easy to implement industrial production. DETAILED DESCRIPTION

[0022] In order to further understand the creativity and technical advancement of the present invention, the preferred embodiments of the present invention are discussed in detail below in conjunction with examples and comparative examples. Example

[0023] A universal antiviral eye drop comprises at least 5-19 parts by mass of sodium chloride and 81-95 parts by mass of high-purity water, and the content of sodium chloride in the universal antiviral eye drop is 5-19wt%.

[0024] The sodium chloride may be any of 4N, 5N, and 6N grades.

[0025] The high-purity water complies with EW-I electronic grade water or EW-II electronic grade water specified in GB / T 11446.1-1997. Preferably, the high-purity water complies with EW-II electronic grade water specified in GB / T 11446.1-1997.

[0026] Universal antiviral eye drops are divided into low-concentration antiviral eye drops and high-concentration antiviral eye drops.

[0027] The content of sodium chloride in the low-concentration antiviral eye drops is 5-11wt%.

[0028] The content of sodium chloride in high-concentration antiviral eye drops is 11-19wt%.

[0029] Preferably, the high-purity water includes EW-I electronic grade water or EW-II electronic grade water, and also includes terahertz water, and the terahertz water content is 500-2000 ppm.

[0030] Further preferably, the low-concentration antiviral eye drops are composed of 5-11 wt% sodium chloride, 500-2000 ppm terahertz water, and the remainder is EW-I electronic grade water or EW-II electronic grade water.

[0031] Further preferably, the high-concentration antiviral eye drops are composed of 11-19 wt% sodium chloride, 500-2000 ppm terahertz water, and the remainder is EW-I electronic grade water or EW-II electronic grade water.

[0032] A method for preparing universal antiviral eye drops, comprising the following steps: Step 1: Place the glass reactor in an ISO Class 1 or ISO Class 5 dust-free workshop. Rinse the glass reactor multiple times with EW-II electronic-grade water. Then, test the cleaning solution for resistivity, 1µm particle count, and total organic carbon. When the cleaning solution's resistivity is less than 14MΩ·cm (25°C), the 1µm particle count is less than 12 particles / mL, and the total organic carbon is less than 110µg / L, and the cleaning solution's resistivity, 1µm particle count, and total organic carbon meet the standards after the third rinse, the glass reactor is rinsed and dried to remove water vapor. Step 2: high-purity water is introduced into the glass reactor, and then 4N grade sodium chloride, 5N grade sodium chloride or 6N grade sodium chloride is added to the glass reactor. An ultrasonic oscillator is set up 0.1-0.5 cm from the bottom of the glass reactor. The frequency of the ultrasonic oscillator is 40-80kHz, the power is 600-1200W, the ultrasonic oscillation is performed for 15-30 minutes, and the mixture is allowed to stand for 0.5-24 hours. The universal antiviral eye drops are then filtered through a nanofiltration membrane and filled.

[0033] Example 1: A method for preparing universal antiviral eye drops, comprising the following steps: Step 1: Place the glass reactor in an ISO Class 1 or ISO Class 5 dust-free workshop. Rinse the glass reactor three times with EW-II electronic-grade water. Then, test the resistivity, 1µm particle count, and total organic carbon of the cleaning solution. When the resistivity of the cleaning solution is less than 14MΩ·cm (25°C), the 1µm particle count is less than 12 particles / mL, and the total organic carbon is less than 110µg / L, and the resistivity, 1µm particle count, and total organic carbon of the cleaning solution meet the standards after the third rinse, the glass reactor is rinsed and dried to remove water vapor. Step 2: 4.75 L of EW-II electronic grade water is introduced into the glass reactor, and then 250 g of 6N grade sodium chloride is added to the glass reactor. An ultrasonic oscillator is set up 0.2 cm from the bottom of the glass reactor. The frequency of the ultrasonic oscillator is 60 kHz, the power is 750 W, the ultrasonic oscillation is performed for 30 minutes, and the product is allowed to stand for 2 hours. The product is filtered through a nanofiltration membrane and filled to obtain universal antiviral eye drops.

[0034] The difference between Example 2 and Example 1 is: a method for preparing a universal antiviral eye drops is: step 2, 4.6L of EW-II electronic grade water is introduced into the glass reactor, and then 400g of 6N grade sodium chloride is added to the glass reactor, an ultrasonic oscillator is set up 0.2cm from the bottom of the glass reactor, the frequency of the ultrasonic oscillator is 60kHz, the power is 750W, the ultrasonic oscillation is performed for 30min, and the mixture is allowed to stand for 2h. The universal antiviral eye drops are obtained by filtering through a nanofiltration membrane and filling.

[0035] The difference between Example 3 and Example 1 is: a method for preparing a universal antiviral eye drops is: step 2, 4.45L of EW-II electronic grade water is introduced into the glass reactor, and then 550g of 6N grade sodium chloride is added to the glass reactor, an ultrasonic oscillator is set up 0.2cm from the bottom of the glass reactor, the frequency of the ultrasonic oscillator is 60kHz, the power is 750W, the ultrasonic oscillation is performed for 30min, and the mixture is allowed to stand for 2h. The universal antiviral eye drops are obtained by filtering through a nanofiltration membrane and filling.

[0036] The difference between Example 4 and Example 1 is: a method for preparing a universal antiviral eye drops is: step 2, 4.25L of EW-II electronic grade water is introduced into the glass reactor, and then 750g of 6N grade sodium chloride is added to the glass reactor, an ultrasonic oscillator is set up 0.2cm from the bottom of the glass reactor, the frequency of the ultrasonic oscillator is 60kHz, the power is 750W, the ultrasonic oscillation is performed for 30min, and the mixture is allowed to stand for 2h. The universal antiviral eye drops are obtained by filtering through a nanofiltration membrane and filling.

[0037] The difference between Example 5 and Example 1 is: a method for preparing a universal antiviral eye drops is: step 2, 4.1L of EW-II electronic grade water is introduced into the glass reactor, and then 900g of 6N grade sodium chloride is added to the glass reactor, an ultrasonic oscillator is set up 0.2cm from the bottom of the glass reactor, the frequency of the ultrasonic oscillator is 60kHz, the power is 750W, the ultrasonic oscillation is performed for 30min, and the mixture is allowed to stand for 2h. The universal antiviral eye drops are obtained by filtering through a nanofiltration membrane and filling.

[0038] The difference between Example 6 and Example 1 is: a method for preparing a universal antiviral eye drops is: step 2, 4745g of EW-II electronic grade water and 5g of terahertz water are introduced into the glass reactor, and then 250g of 6N grade sodium chloride is added to the glass reactor, an ultrasonic oscillator is set up 0.2cm at the bottom of the glass reactor, the frequency of the ultrasonic oscillator is 60kHz, the power is 750W, the ultrasonic oscillation is performed for 30min, and the mixture is allowed to stand for 2h. The universal antiviral eye drops can be obtained by filtering through a nanofiltration membrane and filling.

[0039] The difference between Example 7 and Example 1 is: a method for preparing a universal antiviral eye drops is: step 2, 4595g of EW-II electronic grade water and 5g of terahertz water are introduced into the glass reactor, and then 400g of 6N grade sodium chloride is added to the glass reactor, an ultrasonic oscillator is set up 0.2cm from the bottom of the glass reactor, the frequency of the ultrasonic oscillator is 60kHz, the power is 750W, the ultrasonic oscillation is performed for 30min, and the mixture is allowed to stand for 2h. The universal antiviral eye drops can be obtained by filtering through a nanofiltration membrane and filling.

[0040] The difference between Example 8 and Example 1 is: a method for preparing a universal antiviral eye drops is: step 2, 4245g of EW-II electronic grade water and 5g of terahertz water are introduced into the glass reactor, and then 750g of 6N grade sodium chloride is added to the glass reactor, and an ultrasonic oscillator is set up 0.2cm from the bottom of the glass reactor. The frequency of the ultrasonic oscillator is 60kHz, the power is 750W, the ultrasonic oscillation is performed for 30min, and the mixture is allowed to stand for 2h. The universal antiviral eye drops are obtained by filtering through a nanofiltration membrane and filling.

[0041] The difference between Comparative Example 1 and Example 1 is that the preparation method of the eye drops is as follows: Step 2, 4.85L of EW-II electronic grade water is introduced into the glass reactor, and then 150g of 6N grade sodium chloride is added to the glass reactor, and an ultrasonic oscillator is set up 0.2cm from the bottom of the glass reactor. The frequency of the ultrasonic oscillator is 60kHz, the power is 750W, the ultrasonic oscillation is performed for 30min, and the mixture is allowed to stand for 2h. The universal antiviral eye drops can be obtained by filtering through a nanofiltration membrane and filling.

[0042] Comparative Example 2 differs from Example 1 in that the eye drops are prepared in the following manner: Step 2: 4 L of EW-II electronic-grade water is introduced into a glass reactor, followed by 1 kg of 6N sodium chloride. An ultrasonic oscillator is placed 0.2 cm from the bottom of the glass reactor. The ultrasonic oscillator is operated at a frequency of 60 kHz and a power of 750 W for 30 minutes. The product is then allowed to stand for 2 hours. The product is then filtered through a nanofiltration membrane and bottled to obtain the universal antiviral eye drops. Volunteer test feedback: The eye drops in Comparative Example 2 have a high salinity and are irritating to the eye membrane.

[0043] The test method for antiviral rate is as follows: ①Virus strains: herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), influenza virus type A (IAV), and coxsackievirus type B1 (CVB1).

[0044] ②Cell culture: Vero cells, MDCK cells, A549 cells.

[0045] ③Inhibitory effect evaluation: 1. Cytotoxicity assay: The MTT assay was used to determine the cytotoxicity of the virus to cells.

[0046] 2. Determination of antibacterial effect: The plaque reduction method was used to measure the antibacterial effect of eye drops on HSV-1 and HSV-2.

[0047] Determination of antiviral effect: The TCID50 assay was used to determine the antiviral effect of the eye drops on IAV and CVB1.

[0048] The eye drops in Example 1 reduced the tissue culture infectious dose (TCID50) of HSV-1, HSV-2, IAV and CVB1 by 100 times, 100 times, 100 times and 50 times, respectively.

[0049] The eye drops in Example 2 reduced the tissue culture infectious dose (TCID50) of HSV-1, HSV-2, IAV, and CVB1 by 100 times, 100 times, 100 times, and 100 times, respectively.

[0050] The eye drops in Example 3 reduced the tissue culture infectious dose (TCID50) of HSV-1, HSV-2, IAV, and CVB1 by 100 times, 100 times, 100 times, and 100 times, respectively.

[0051] The eye drops in Example 4 reduced the tissue culture infectious dose (TCID50) of HSV-1, HSV-2, IAV, and CVB1 by 100 times, 100 times, 100 times, and 100 times, respectively.

[0052] The eye drops in Example 5 reduced the tissue culture infectious dose (TCID50) of HSV-1, HSV-2, IAV, and CVB1 by 100 times, 100 times, 100 times, and 100 times, respectively.

[0053] The eye drops in Example 6 reduced the tissue culture infectious dose (TCID50) of HSV-1, HSV-2, IAV, and CVB1 by 100 times, 100 times, 100 times, and 100 times, respectively.

[0054] The eye drops in Example 7 reduced the tissue culture infectious dose (TCID50) of HSV-1, HSV-2, IAV, and CVB1 by 100 times, 100 times, 100 times, and 100 times, respectively.

[0055] The eye drops in Example 8 reduced the tissue culture infectious dose (TCID50) of HSV-1, HSV-2, IAV, and CVB1 by 100 times, 100 times, 100 times, and 100 times, respectively.

[0056] The eye drops in Comparative Example 1 reduced the half tissue culture infectious dose (TCID50) of HSV-1, HSV-2, IAV and CVB1 by 50 times, 50 times, 40 times and 20 times respectively.

[0057] The eye drops in Comparative Example 2 reduced the half tissue culture infectious dose (TCID50) of HSV-1, HSV-2, IAV, and CVB1 by 100 times, 100 times, 100 times, and 100 times, respectively.

[0058] Decrease rate P=M 测前 / M 测后 , M 测前 is the number of viruses before testing; M 测后 is the number of viruses before testing.

[0059] The test conclusions are as follows: 1. The eye drops in Examples 1-7 and Comparative Examples 1-2 showed no significant cytotoxicity to Vero cells, MDCK cells, and A549 cells.

[0060] 2. The eye drops in Examples 1-7 and Comparative Example 2 have obvious antibacterial effects on HSV-1, HSV-2, IAV, and CVB1.

[0061] For volunteer testing methods, please refer to: Method ①, Method ②, Method ③.

[0062] Each group of test volunteers consists of 5, with a total of 15 test volunteers. The time it takes for the volunteers to be cured after using the eye drops in method ①, method ②, and method ③, whether the symptoms are relieved, and the number of days to cure are recorded.

[0063] ① Single eye drops method: first use the 5wt% NaCl eye drops in Example 1 and add them once. After 8h, use the 8wt% NaCl eye drops in Example 2 and add them twice, with a single interval of 8h. Then use the 11wt% NaCl eye drops in Example 3 and add them twice, with a single interval of 8h. Then use the 15wt% NaCl eye drops in Example 4 and add them twice, with a single interval of 8h. Then use the 18wt% NaCl eye drops in Example 5 and add them once. Then, every 8h, add the 18wt% NaCl eye drops in Example 5.

[0064] ② Single eye drops addition method: first use the 5wt% NaCl + terahertz water eye drops in Example 6 to add once, and after 8 hours, use the 8wt% NaCl + terahertz water eye drops in Example 7 to add twice, with a single interval of 8 hours, then use the 11wt% NaCl eye drops in Example 3 to add twice, with a single interval of 8 hours, then use the 15wt% NaCl + terahertz water eye drops in Example 8 to add twice, with a single interval of 8 hours, then use the 18wt% NaCl eye drops in Example 5 to add once, and then add 18wt% NaCl eye drops in Example 5 every 8 hours.

[0065] ③ Single-time eye drops addition method: Use the 3 wt% NaCl eye drops in Comparative Example 1 and add once every 8 hours.

[0066] In method ①, the symptoms of the five test volunteers were relieved after 2 days of use, and the symptoms were significantly relieved after 4 days of use. Three volunteers were cured after 6 days of use, and the other two volunteers were cured after 7 days of use.

[0067] In method ②, the symptoms of the five test volunteers were relieved after 2 days of use, and the symptoms were significantly relieved after 3 days of use. Four volunteers were cured after 5 days of use, and another volunteer was cured after 6 days of use.

[0068] In method ③, the symptoms of the five test volunteers were relieved after 3 days of use, and the symptoms were significantly relieved after 7 days of use, but none of the five test volunteers were cured after 7 days of use.

[0069] It can be seen from this that the terahertz water of appropriate concentration in the present invention can assist in improving the virus-disinfecting ability of the sodium chloride aqueous solution of appropriate concentration, shorten the healing time, and improve the therapeutic effect on multiple viral eye diseases.

[0070] In summary, the eye drops of the present invention have few impurities, pure raw materials, little eye irritation, are suitable for a wide range of people, and can effectively eliminate viruses and treat eye diseases caused by viruses.

[0071] It should be noted that this specific embodiment is merely an explanation of the technical solution of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to this embodiment as needed, but as long as they are within the scope of the claims of the present invention, they are protected by patent law.

Claims

1. A universal antiviral eye drops, characterized by: The universal antiviral eye drops contain at least 5-19 parts by mass of sodium chloride and 81-95 parts by mass of high-purity water, wherein the content of sodium chloride in the universal antiviral eye drops is 5-19wt%.

2. The universal antiviral eye drops according to claim 1, characterized in that: The content of sodium chloride in the universal antiviral eye drops is 5-11 wt %.

3. The universal antiviral eye drops according to claim 1, characterized in that: The content of sodium chloride in the universal antiviral eye drops is 11-19 wt %.

4. The universal antiviral eye drops according to claim 1, characterized in that: The high-purity water complies with EW-I electronic grade water or EW-II electronic grade water specified in GB / T11446.1-1997.

5. The universal antiviral eye drops according to claim 1, characterized in that: The sodium chloride is any one of 4N grade, 5N grade and 6N grade.

6. The universal antiviral eye drops according to claim 1, characterized in that: The high-purity water includes EW-I electronic grade water or EW-II electronic grade water, and also includes terahertz water.

7. The universal antiviral eye drops according to claim 6, characterized in that: The terahertz water content in the universal antiviral eye drops is 500-2000 ppm.

8. The universal antiviral eye drops according to claim 6, characterized in that: The universal antiviral eye drops are divided into low-concentration antiviral eye drops and high-concentration antiviral eye drops. The low-concentration antiviral eye drops are composed of 5-11wt% of sodium chloride, 500-2000ppm of terahertz water, and the remainder is EW-I electronic grade water or EW-II electronic grade water; the high-concentration antiviral eye drops are composed of 11-19wt% of sodium chloride, 500-2000ppm of terahertz water, and the remainder is EW-I electronic grade water or EW-II electronic grade water.

9. The method for preparing a universal antiviral eye drops according to claim 8, characterized in that: The low-concentration antiviral eye drops are composed of 8-9wt% sodium chloride, 80-120ppm terahertz water, and the balance is EW-II electronic grade water; the high-concentration antiviral eye drops are composed of 15-16wt% sodium chloride, 80-120ppm terahertz water, and the balance is EW-II electronic grade water.

10. A method for preparing the universal antiviral eye drops according to any one of claims 1 to 9, characterized in that: The following steps are involved: Step 1: Place the glass reactor in an ISO Class 1 or ISO Class 5 cleanroom. Rinse the reactor multiple times with high-purity water. Then test the cleaning solution for resistivity, 1µm particle count, and total organic carbon. When the cleaning solution's resistivity is less than 14MΩ·cm (25°C), the 1µm particle count is less than 12 particles / mL, and the total organic carbon is less than 110µg / L, the glass reactor is rinsed and dried to remove any water vapor. Step 2: high-purity water is introduced into the glass reactor, and then 4N grade sodium chloride, 5N grade sodium chloride or 6N grade sodium chloride is added to the glass reactor. An ultrasonic oscillator is set up 0.1-0.5 cm from the bottom of the glass reactor. The frequency of the ultrasonic oscillator is 40-80kHz, the power is 600-1200W, the ultrasonic oscillation is performed for 15-30 minutes, and the mixture is allowed to stand for 0.5-24 hours. The universal antiviral eye drops are then filtered through a nanofiltration membrane and filled.