Three-leaf heart-purging mouthwash and preparation process thereof

Abstract

The invention relates to the technical field of gargle, in particular to a three-leaf heart-purging gargle and a preparation process thereof, and the three-leaf heart-purging gargle is prepared from the following raw materials in parts by weight: 24-36 parts of a basic heat-clearing system; the basic heat clearing system is prepared from the following components in parts by mass: 17-23 parts of radix scutellariae and 17-23 parts of radix et rhizoma rhei; 7 to 13 parts of rheum officinale; 12 to 18 parts of a synergistic anti-inflammatory agent; 9-15 parts of a mucous membrane repairing agent; 0.3 to 0.8 part of a cool and refreshing soothing agent; and 55.1 to 69 parts of an auxiliary additive. The three-leaf heart-purging mouthwash takes natural traditional Chinese medicinal materials such as scutellaria baicalensis and tetrastigma hemsleyanum as core components, avoids side effects of tooth staining, taste change and mucosal lesion caused by chemical antibacterial agents, reduces dependence on preservatives and irritation to the oral cavity through scientific proportioning and process optimization, is suitable for long-term use, and has a good market prospect. The mouthwash is especially suitable for people sensitive to chemical components, and various defects of traditional mouthwash are overcome.

Description

Technical Field

[0001] The invention relates to the technical field of mouthwashes, in particular to a Sanye Xiexin mouthwash and a preparation process thereof. Background Art

[0002] Mouthwash is a daily chemical product that is often used in daily life. Generally, it includes the following types:

[0003] Chemical antibacterial mouthwashes are a mainstream product on the market, primarily relying on chemical antimicrobial agents. Common antimicrobial ingredients include chlorhexidine, cetylpyridinium chloride, and benzalkonium chloride. Chlorhexidine adsorbs on bacterial surfaces, altering cell membrane permeability and allowing bacterial substances to escape, thereby achieving a bactericidal effect. Cetylpyridinium chloride, on the other hand, inhibits bacterial adhesion and growth by reducing surface tension. This type of mouthwash has a broad antimicrobial spectrum, demonstrating significant inhibitory effects against common oral bacteria such as Streptococcus mutans and Staphylococcus aureus. It can effectively reduce dental plaque formation and prevent caries and periodontitis. Herbal extract mouthwashes are made from natural plants, extracting active ingredients with antibacterial, anti-inflammatory, and antioxidant properties. For example, mouthwashes containing tea tree oil, whose terpenoids can disrupt bacterial cell membranes and exert antibacterial effects, can also contain catechins, which have antioxidant and anti-inflammatory properties and can reduce gum inflammation. This type of mouthwash offers consumers a natural and gentle impression, making it suitable for those sensitive to chemical ingredients. Enzyme mouthwashes utilize the specific catalytic action of enzymes to achieve oral care. For example, mouthwashes containing lysozyme can break down the mucopolysaccharides in bacterial cell walls, dissolving and killing the bacteria. Glucanase can break down glucans in dental plaque, inhibiting its formation and progression. Enzyme mouthwashes are gentle and minimally disrupt the oral microbiome.

[0004] However, the above mouthwashes still have the following defects:

[0005] Long-term use of chemical antibacterial mouthwashes, such as chlorhexidine, can lead to drug resistance in oral bacteria, gradually reducing the antibacterial effect. Once use is discontinued, bacteria can easily rebound and proliferate, potentially causing an imbalance in the oral flora, leading to overgrowth of fungi such as Candida albicans and oral candidiasis. Some chemical antibacterial agents can stain teeth and mucous membranes, causing yellowing or brown spots on the tooth surface. They can also affect taste, leading to a decreased or abnormal sense of taste. Long-term use can also damage the oral mucosa, causing dryness, a burning sensation, and other discomfort.

[0006] The active ingredients in natural plant extracts of herbal plant extract mouthwashes are easily degraded by environmental factors such as light and temperature, resulting in a shorter shelf life of the product. More preservatives need to be added to maintain stability, which may increase irritation to the oral cavity. Compared with chemical antibacterial agents, the antibacterial activity of herbal plant extracts is relatively weak. When dealing with severe oral inflammation or a large number of pathogens, it is difficult to control the infection quickly and effectively, and the treatment effect is not ideal.

[0007] The catalytic action of enzymes in enzymatic mouthwashes requires specific conditions such as temperature and pH. The complex and ever-changing environment in the oral cavity may affect the activity of the enzymes, preventing them from fully functioning. For example, various components in saliva may interact with enzymes, reducing their stability and catalytic efficiency. Different enzymes act on specific substrates, and a single enzyme mouthwash is unlikely to fully address multiple oral problems. For example, lysozyme is primarily effective against Gram-positive bacteria, but ineffective against Gram-negative bacteria, making it unable to meet diverse oral care needs.

[0008] Aromatic mouthwashes rely solely on fragrance to mask bad breath, but fail to address the root causes of bad breath, such as the volatile sulfides produced by oral bacteria breaking down food debris. Once the aromatic scent dissipates, the bad breath problem persists. These mouthwashes typically lack antibacterial and anti-inflammatory properties, making them ineffective in preventing and treating oral diseases. Long-term use can delay treatment of oral problems and worsen them.

[0009] Based on this, the present invention provides a Sanye Xiexin mouthwash and a preparation process thereof to solve the above-mentioned technical problems. Summary of the Invention

[0010] The purpose of the present invention is to provide a Sanye Xiexin mouthwash and a preparation process thereof, so as to solve the problems mentioned in the above background technology.

[0011] To achieve the above object, the present invention provides the following technical solutions:

[0012] The present invention provides a Sanye Xiexin mouthwash, which is composed of the following raw materials in parts by weight:

[0013] Basic heat-clearing system: 24-36 servings;

[0014] The basic heat-clearing system is composed of scutellaria baicalensis and rhubarb, and the scutellaria baicalensis and rhubarb are respectively as follows: scutellaria baicalensis: 17-23 parts; rhubarb: 7-13 parts;

[0015] Enhance heat-clearing system: 12-18 parts;

[0016] The enhanced heat-clearing system is composed of dandelion, Senecio radix, Indigo naturalis and Parsley septificata respectively, wherein the dandelion, Senecio radix, Indigo naturalis and Parsley septificata are respectively in the following proportions by weight: dandelion: 5-9 parts; Senecio radix: 4-9 parts; Indigo naturalis: 1-2 parts; Parsley septificata: 1-2 parts;

[0017] Synergistic anti-inflammatory agent: 12-18 parts;

[0018] Mucosal repair agent: 9-15 parts;

[0019] Cooling and soothing agent: 0.3-0.8 parts;

[0020] Auxiliary additives: 55.1-69 parts;

[0021] The auxiliary additives are composed of glycerol, xylitol, polysorbate 80 and sodium benzoate, and the glycerol, xylitol, polysorbate 80 and sodium benzoate are respectively as follows in parts by mass: glycerol: 47-53 parts; xylitol: 7-13 parts; polysorbate 80: 0.8-1.2 parts; sodium benzoate: 0.3-0.8 parts.

[0022] Preferably, the synergistic anti-inflammatory agent is Tripterygium wilfordii.

[0023] Preferably, the mucosal repair agent is licorice.

[0024] Preferably, the cooling and soothing agent is menthol.

[0025] The present invention also provides a preparation process of Sanye Xiexin mouthwash, comprising the following steps:

[0026] S1. Weigh the basic heat-clearing system medicinal materials: Scutellaria baicalensis: 17-23 parts, Rhubarb: 7-13 parts; synergistic anti-inflammatory agent: Tripterygium wilfordii: 12-18 parts; mucosal repair agent: Licorice: 9-15 parts; remove impurities from all medicinal materials, crush them separately, and pass them through a 60-mesh sieve to ensure uniform particles: particle size ≤ 0.3mm; mix the crushed medicinal materials according to the proportion, add 8 times the amount of distilled water, the amount of water calculated based on the total weight of the medicinal materials: the total amount of medicinal materials is 57-87 parts for the basic heat-clearing system plus Tripterygium wilfordii and Licorice, or 456-696 parts of distilled water, soak for 1 hour to allow the medicinal materials to fully absorb water and expand; heat and reflux extraction at 80°C twice, each time for 2 hours; during the extraction process, the active ingredients of baicalin from Scutellaria baicalensis, emodin from Rhubarb, flavonoids from Tripterygium wilfordii, and glycyrrhizic acid from Licorice are fully dissolved; finally, filter and concentrate;

[0027] S2. Dissolving and mixing excipients: weighing excipients: 47-53 parts glycerol, 7-13 parts xylitol, 0.8-1.2 parts polysorbate 80, 0.3-0.8 parts sodium benzoate; dissolving operation: glycerol, xylitol, polysorbate 80, sodium benzoate were added to 200 parts of distilled water in sequence and stirred until completely dissolved to form an excipient mixture; and menthol was processed;

[0028] S3. Preparation of finished product: slowly add 190-290 parts of Chinese medicine concentrate to the auxiliary material mixture, stirring while adding, with a speed ≥500rpm; dilute the volume to 1000 parts, i.e. 1000mL, with distilled water, and continue stirring for 20 minutes to ensure uniformity; after the finished product is tested to have a pH of 5.5-6.5 and no precipitation, it is packaged into sterilized mouthwash bottles, 50-250mL per bottle; sealed and stored in a dark environment below 25°C.

[0029] Preferably, the filtration and concentration operation in step S1 includes:

[0030] Coarse filtration: Filter the extract while hot through double-layer gauze to remove the drug residue;

[0031] Fine filtration: The filtrate is passed through a 0.45 μm microporous filter membrane to obtain a clarified extract;

[0032] Concentration: The refined filtrate is concentrated to 1 / 3 of the original volume using a rotary evaporator at 60°C under reduced pressure. The volume after concentration is 190-290 parts per million and the density is 1.1-1.2 g / mL.

[0033] Preferably, the menthol treatment step S2 is as follows: pre-dissolve 0.3-0.8 parts of the cooling and soothing agent menthol in 1.5-4 parts of 5 times the amount of ethanol, slowly add the auxiliary material mixture, and stir for 10 minutes until uniformly dispersed.

[0034] Compared with the prior art, the present invention has the following beneficial effects:

[0035] The Sanye Xiexin mouthwash of the present invention uses natural Chinese medicinal materials such as Scutellaria baicalensis and Tripterygium wilfordii as core ingredients, avoiding the side effects of tooth staining, taste changes, and mucosal damage caused by chemical antibacterial agents. At the same time, through scientific proportioning and process optimization, it reduces dependence on preservatives and reduces irritation to the oral cavity. It is suitable for long-term use, especially for people who are sensitive to chemical components, and solves various shortcomings of traditional mouthwashes. DETAILED DESCRIPTION

[0036] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts shall fall within the scope of protection of the present invention.

[0037] 1. Process:

[0038] The present invention provides a Sanye Xiexin mouthwash, and the materials are commercially available unless otherwise specified:

[0039] It is composed of the following raw materials in parts by weight:

[0040] Basic heat-clearing system: 24-36 servings;

[0041] The basic heat-clearing system is composed of scutellaria baicalensis and rhubarb, and the scutellaria baicalensis and rhubarb are respectively as follows: scutellaria baicalensis: 17-23 parts; rhubarb: 7-13 parts;

[0042] Enhance heat-clearing system: 12-18 parts;

[0043] The enhanced heat-clearing system is composed of dandelion, Senecio radix, Indigo naturalis and Parsley septificata respectively, wherein the dandelion, Senecio radix, Indigo naturalis and Parsley septificata are respectively in the following proportions by weight: dandelion: 5-9 parts; Senecio radix: 4-9 parts; Indigo naturalis: 1-2 parts; Parsley septificata: 1-2 parts;

[0044] Synergistic anti-inflammatory agent: 12-18 parts;

[0045] Mucosal repair agent: 9-15 parts;

[0046] Cooling and soothing agent: 0.3-0.8 parts;

[0047] Auxiliary additives: 55.1-69 parts;

[0048] The auxiliary additives are composed of glycerol, xylitol, polysorbate 80 and sodium benzoate, and the glycerol, xylitol, polysorbate 80 and sodium benzoate are respectively as follows in parts by mass: glycerol: 47-53 parts; xylitol: 7-13 parts; polysorbate 80: 0.8-1.2 parts; sodium benzoate: 0.3-0.8 parts.

[0049] Among them, it should be noted that the synergistic anti-inflammatory agent is specifically Tripterygium wilfordii.

[0050] Among them, it should be noted that the mucosal repair agent is specifically licorice.

[0051] It should also be noted that the cooling and soothing agent is specifically menthol.

[0052] 2. Process:

[0053] Based on the above formula, the present invention also proposes a preparation process of Sanye Xiexin mouthwash, comprising the following steps:

[0054] S1. Weigh the basic heat-clearing system herbs: Scutellaria baicalensis: 17-23 parts, Rhubarb: 7-13 parts; synergistic anti-inflammatory agent: Tripterygium wilfordii: 12-18 parts; mucosal repair agent: Licorice: 9-15 parts; weigh the enhanced herbs: Taraxacum mongolicum: 5-9 parts; Senecio radix: 4-9 parts; Indigo naturalis: 1-2 parts; Parsley striata: 1-2 parts; remove impurities from all herbs, crush them separately, and pass through a 60-mesh sieve to ensure uniform particles (particle size ≤ 0.3mm); mix the crushed herbs in proportion. Combine, add 8 times the amount of distilled water, the amount of water is calculated according to the total weight of the medicinal materials: the total amount of the medicinal materials is based on the heat-clearing system, plus 57 to 87 parts of Tripterygium wilfordii and licorice, that is, 456 to 696 parts of distilled water, soak for 1 hour to allow the medicinal materials to fully absorb water and swell; heat and reflux extraction at 80°C twice, each time for 2 hours; during the extraction process, the effective components of baicalin in Scutellaria baicalensis, emodin in Rhubarb, flavonoids in Tripterygium wilfordii, and glycyrrhizic acid in Licorice are fully dissolved; finally, filter and concentrate;

[0055] S2. Dissolving and mixing excipients: weighing excipients: 47-53 parts glycerol, 7-13 parts xylitol, 0.8-1.2 parts polysorbate 80, 0.3-0.8 parts sodium benzoate; dissolving operation: glycerol, xylitol, polysorbate 80, sodium benzoate were added to 200 parts of distilled water in sequence and stirred until completely dissolved to form an excipient mixture; and menthol was processed;

[0056] S3. Preparation of finished product: slowly add 190-290 parts of Chinese medicine concentrate to the auxiliary material mixture, stirring while adding, with a speed ≥500rpm; dilute the volume to 1000 parts, i.e. 1000mL, with distilled water, and continue stirring for 20 minutes to ensure uniformity; after the finished product is tested to have a pH of 5.5-6.5 and no precipitation, it is packaged into sterilized mouthwash bottles, 50-250mL per bottle; sealed and stored in a dark environment below 25°C.

[0057] It should be noted that the filtration and concentration operation in step S1 includes:

[0058] Coarse filtration: Filter the extract while hot through double-layer gauze to remove the drug residue;

[0059] Fine filtration: The filtrate is passed through a 0.45 μm microporous filter membrane to obtain a clarified extract;

[0060] Concentration: The refined filtrate is concentrated to 1 / 3 of the original volume using a rotary evaporator at 60°C under reduced pressure. The volume after concentration is 190-290 parts per million and the density is 1.1-1.2 g / mL.

[0061] It should also be noted that step S2 of treating menthol is as follows: pre-dissolve 0.3-0.8 parts of the cooling and soothing agent menthol in 1.5-4 parts of 5 times the amount of ethanol, slowly add the auxiliary material mixture, and stir for 10 minutes until evenly dispersed.

[0062] Example 1: In this example, a preparation process of a Sanye Xiexin mouthwash is provided, and the steps are as follows:

[0063] S1. Traditional Chinese Medicine Extraction: Weigh 20 parts of Scutellaria baicalensis, 10 parts of Rhubarb, and 12 parts of Glycyrrhiza uralensis, and grind through a 60-mesh sieve. Soak the mixed herbs (72 parts total) in 576 parts of distilled water for 1 hour. Refluxing extraction was performed at 80°C twice (2 hours each time), and the combined extracts were subjected to coarse filtration followed by fine filtration through a 0.45 μm filter membrane. The extracts were then concentrated under reduced pressure at 60°C to 240 parts (density 1.15 g / mL).

[0064] S2 excipients dissolved: 50 parts of glycerol, 10 parts of xylitol, 1.0 parts of polysorbate 80, 0.5 parts of sodium benzoate were added to 200 parts of distilled water and stirred to dissolve; 0.5 parts of menthol were pre-dissolved with 2.5 parts of ethanol, and the excipient solution was added and stirred for 10 minutes;

[0065] S3. Preparation of finished product: Add the auxiliary liquid to the concentrate (240 parts) and stir at 500 rpm to mix; distilled water to 1000 mL → dispense into 50 mL sterile bottles.

[0066] Example 2: A Sanye Xiexin mouthwash was prepared according to the formula of each component in Example 2 in Table 1, and the process steps were the same as in Example 1;

[0067] Example 3: A Sanye Xiexin mouthwash was prepared according to the formula of each component in Example 3 in Table 1, and the process steps were the same as in Example 1;

[0068] The material component parameters of Examples 1-3 are shown in Table 1:

[0069] Table 1: Example material component parameters

[0070]

[0071]

[0072] Comparative Example 1: In this comparative example, 10 parts of Scutellaria baicalensis were used, and the other processes and components were the same as in Example 1; Comparative Example 2: In this comparative example, 25 parts of Scutellaria baicalensis were used, and the other processes and components were the same as in Example 1; Comparative Example 3: In this comparative example, 8 parts of Licorice were used, and the other processes and components were the same as in Example 1; the material component parameters of Comparative Examples 1-3 are shown in Table 2:

[0073] Table 2: Comparative Example Material Component Parameters

[0074]

[0075]

[0076] 3. Performance test:

[0077] 1. Sample Preparation:

[0078] Extraction process: Crush the medicinal material and pass it through a 60-mesh sieve (particle size ≤ 0.3 mm) → Soak in 8 times the amount of distilled water for 1 hour → Reflux extraction at 80°C twice (2 hours each time) → Coarse filtration (double-layer gauze) → Fine filtration (0.45 μm filter membrane) → Concentrate under reduced pressure at 60°C to a density of 1.1-1.2 g / mL;

[0079] Mixing of auxiliary materials: dissolve auxiliary materials in 200 parts of distilled water → pre-dissolve menthol in 5 times ethanol and add → stir for 10 minutes;

[0080] Finished product preparation: Add the concentrate to the auxiliary liquid → stir at 500rpm → adjust the volume to 1000mL → aliquot and sterilize;

[0081] 2. Performance testing:

[0082] Inhibition rate (Streptococcus mutans): agar dilution method (37°C, 24 h), calculate the diameter of the inhibition zone (mm);

[0083] Anti-inflammatory activity (TNF-α inhibition rate): LPS induced inflammation in human gingival cells, and ELISA was used to detect the release of TNF-α.

[0084] Mucosal repair rate: scratch test (human oral mucosal cells), percentage of migration area after 24 hours;

[0085] Taste rating: 10 people blind test (0-10 points, cooling sensation + bitterness tolerance);

[0086] The performance parameters of Examples 1-3 are recorded in Table 3:

[0087] Table 3: Performance data of the embodiment

[0088]

[0089]

[0090] The performance parameters of Comparative Examples 1-4 are recorded in Table 4:

[0091] Table 4: Comparative Example Performance Data

[0092] Test items Comparative Example 1 Comparative Example 2 Comparative Example 3 Antibacterial rate (%) 78.5 82.1 83.7 TNF-α inhibition rate (%) 70.2 68.9 72.4 Mucosal repair rate (%) 75.3 74.8 65.2 Taste score 6.8 5.1 7.5

[0093] 4. Analysis Conclusions:

[0094] As shown in Tables 1 to 4, the antibacterial rate of the examples (89.1-96.0%) was significantly higher than that of the comparative examples (65.2-83.7%). Scutellaria baicalensis avoided the excessive bitterness of Parsley; licorice increased the mucosal repair rate to >84.6%, while in Comparative Example 3, 8 parts of licorice only achieved 65.2%; in terms of the balance between stability and taste, 7-13 parts of xylitol gave a taste score of ≥7.2 in the examples, while in Comparative Example 2, the excessive amount of 25 parts of Scutellaria baicalensis resulted in a prominent bitter taste; 0.3-0.8 parts of sodium benzoate ensured a berberine retention rate of >90%, without the risk of insufficient preservation or irritation.

[0095] Furthermore, in Example 1, the antibacterial rate of 95.2%, the TNF-α inhibition rate of 87.5%, and the mucosal repair rate of 91.8% all ranked first among the examples; the taste score of 8.7 points was significantly higher than that of Examples 2 / 3, because Scutellaria 20 balanced the efficacy and bitterness;

[0096] At the same time, the volume of the concentrated liquid and the auxiliary liquid are easy to emulsify to avoid stratification. The comparative example 1 is insufficient, resulting in an extract that is too dilute. In summary, the components of Example 1 of the present invention achieve the optimal balance of efficacy, safety and taste through the combination of monarch, minister, adjuvant and envoy, and are the best embodiment of the present invention.

[0097] In summary, this mouthwash uses natural Chinese medicinal materials such as Scutellaria baicalensis and Tripterygium wilfordii as its core ingredients, avoiding the side effects of chemical antibacterial agents such as tooth staining, taste changes, and mucosal damage. At the same time, through scientific proportions and process optimization, it reduces dependence on preservatives and reduces irritation to the oral cavity. It is suitable for long-term use, especially for people who are sensitive to chemical ingredients.

[0098] The various ingredients in the formula work together to exert antibacterial effects. Rhubarb, Tripterygium wilfordii, etc. have a broad-spectrum inhibitory effect on common oral pathogens and are not prone to drug resistance. Ingredients such as Scutellaria baicalensis and Licorice can effectively inhibit the release of inflammatory factors, reduce inflammatory symptoms such as gum redness and swelling, oral ulcers, etc. Compared with single herbal plant extract mouthwashes, the antibacterial and anti-inflammatory effects are stronger. Glycyrrhizic acid in licorice and anthraquinone components in rhubarb can promote the proliferation of oral mucosal epithelial cells, regulate collagen fiber synthesis, accelerate ulcer healing, and have a good repair effect on problems such as oral ulcers and mucosal damage. It makes up for the lack of substantial care in traditional aromatic mouthwashes. Menthol provides a cool taste and natural aroma, while combined with antibacterial ingredients It can reduce the causes of bad breath from the root, such as inhibiting bacteria from decomposing food residues to produce volatile sulfides, and achieve long-lasting fresh breath. It is more lasting than mouthwashes that simply rely on fragrances to mask odors. Through scientific extraction technology and the addition of auxiliary materials, the stability of the active ingredients of traditional Chinese medicine is improved and the shelf life of the product is extended. At the same time, its mild formula and comprehensive efficacy are suitable for people with a variety of oral problems, including patients with periodontitis, oral ulcers, bad breath and other symptoms, as well as people with daily oral care needs, solving the problem of the narrow application range of enzyme mouthwashes.

[0099] Throughout this specification, references to terms such as "one embodiment," "example," or "specific example" indicate that the specific features, structures, materials, or characteristics described in conjunction with that embodiment or example are included in at least one embodiment or example of the present invention. In this specification, schematic representations of these terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0100] The preferred embodiments of the present invention disclosed above are intended only to help illustrate the present invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the present invention to the specific embodiments described. Obviously, many modifications and variations are possible based on the content of this specification. These embodiments are selected and described in detail in this specification to better explain the principles and practical applications of the present invention, thereby enabling those skilled in the art to better understand and utilize the present invention. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. Sanye Xiexin mouthwash, characterized in that, It is composed of the following raw materials in parts by weight: Basic heat-clearing system: 24-36 servings; The basic heat-clearing system is composed of scutellaria baicalensis and rhubarb, and the scutellaria baicalensis and rhubarb are respectively as follows: scutellaria baicalensis: 17-23 parts; rhubarb: 7-13 parts; Enhance heat-clearing system: 12-18 parts; The enhanced heat-clearing system is composed of dandelion, Senecio radix, Indigo naturalis and Parsley septificata respectively, wherein the dandelion, Senecio radix, Indigo naturalis and Parsley septificata are respectively in the following proportions by weight: dandelion: 5-9 parts; Senecio radix: 4-9 parts; Indigo naturalis: 1-2 parts; Parsley septificata: 1-2 parts; Synergistic anti-inflammatory agent: 12-18 parts; Mucosal repair agent: 9-15 parts; Cooling and soothing agent: 0.3-0.8 parts; Auxiliary additives: 55.1-69 parts; The auxiliary additives are composed of glycerol, xylitol, polysorbate 80 and sodium benzoate, and the glycerol, xylitol, polysorbate 80 and sodium benzoate are respectively as follows in parts by mass: glycerol: 47-53 parts; xylitol: 7-13 parts; polysorbate 80: 0.8-1.2 parts; sodium benzoate: 0.3-0.8 parts.

2. The Sanye Xiexin mouthwash according to claim 1, characterized in that The synergistic anti-inflammatory agent is specifically Tripterygium wilfordii.

3. The Sanye Xiexin mouthwash according to claim 2, characterized in that The mucosal repair agent is specifically licorice.

4. The Sanye Xiexin mouthwash according to claim 1, characterized in that The cooling and soothing agent is specifically menthol.

5. The preparation process of the Sanye Xiexin mouthwash according to any one of claims 1 to 4, characterized in that: The following steps are involved: S1. Weigh the basic heat-clearing system medicinal materials: Scutellaria baicalensis: 17-23 parts, Rhubarb: 7-13 parts; synergistic anti-inflammatory agent: Tripterygium wilfordii: 12-18 parts; mucosal repair agent: Licorice: 9-15 parts; remove impurities from all medicinal materials, crush them separately, and pass them through a 60-mesh sieve to ensure uniform particles: particle size ≤ 0.3mm; mix the crushed medicinal materials according to the proportion, add 8 times the amount of distilled water, the amount of water calculated based on the total weight of the medicinal materials: the total amount of medicinal materials is 57-87 parts for the basic heat-clearing system plus Tripterygium wilfordii and Licorice, or 456-696 parts of distilled water, soak for 1 hour to allow the medicinal materials to fully absorb water and expand; heat and reflux extraction at 80°C twice, each time for 2 hours; during the extraction process, the active ingredients of baicalin from Scutellaria baicalensis, emodin from Rhubarb, flavonoids from Tripterygium wilfordii, and glycyrrhizic acid from Licorice are fully dissolved; finally, filter and concentrate; S2. Dissolving and mixing excipients: weighing excipients: 47-53 parts glycerol, 7-13 parts xylitol, 0.8-1.2 parts polysorbate 80, 0.3-0.8 parts sodium benzoate; dissolving operation: glycerol, xylitol, polysorbate 80, sodium benzoate were added to 200 parts of distilled water in sequence and stirred until completely dissolved to form an excipient mixture; and menthol was processed; S3. Preparation of finished product: slowly add 190-290 parts of Chinese medicine concentrate to the auxiliary material mixture, stirring while adding, with a speed ≥500rpm; dilute the volume to 1000 parts, i.e. 1000mL, with distilled water, and continue stirring for 20 minutes to ensure uniformity; after the finished product is tested to have a pH of 5.5-6.5 and no precipitation, it is packaged into sterilized mouthwash bottles, 50-250mL per bottle; sealed and stored in a dark environment below 25°C.

6. The preparation process of the Sanye Xiexin mouthwash according to claim 5, characterized in that: The filtration and concentration operation in step S1 includes: Coarse filtration: Filter the extract while hot through double-layer gauze to remove the drug residue; Fine filtration: The filtrate is passed through a 0.45 μm microporous filter membrane to obtain a clarified extract; Concentration: The refined filtrate is concentrated to 1 / 3 of the original volume using a rotary evaporator at 60°C under reduced pressure. The volume after concentration is 190-290 parts per million and the density is 1.1-1.2 g / mL.

7. The preparation process of the Sanye Xiexin mouthwash according to claim 6, characterized in that: The step S2 of treating menthol is as follows: pre-dissolve 0.3-0.8 parts of menthol, a cooling and soothing agent, in 1.5-4 parts of 5-fold amount of ethanol, slowly add the auxiliary material mixture, and stir for 10 minutes until uniformly dispersed.

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