Traditional Chinese medicine compound preparation for treating acne and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine compound preparation for treating acne and a preparation method thereof. The traditional Chinese medicine compound preparation is prepared from 15-30 g of fructus forsythiae, 10-20 g of cortex mori, 15-30 g of dandelion, 30-60 g of semen coicis, 6-15 g of raw ephedra, 30-60 g of phaseolus calcaratus, 10-30 g of honeysuckle, 10-15 g of radix sophorae flavescentis, 15-20 g of pogostemon cablin, 10-15 g of radix angelicae, 10-15 g of rhizoma atractylodis, 3-6 g of stevia rebaudiana leaves, 15-30 g of oldenlandia diffusa and 6-15 g of coptis chinensis. The traditional Chinese medicine is prepared from 15-30 g of folium isatidis, 10-15 g of radix paeoniae rubra, 15-30 g of cortex phellodendri, 30-120 g of radix rehmanniae, 30-120 g of gypsum and 10-15 g of cortex moutan. The technology adopts a compound design of a plurality of traditional Chinese medicine components, and combines medicinal materials with the effects of resisting inflammation, resisting bacteria, clearing away heat and toxic materials, promoting blood circulation to remove blood stasis and the like, such as fructus forsythiae, dandelion, honeysuckle, radix sophorae flavescentis and the like; the medicines act together through multiple ways, effectively aim at multiple pathogens (such as sebaceous gland hypersecretion and the like) of acne, and the curative effect limitation possibly generated by a single component is avoided.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine compound preparation for treating acne and a preparation method thereof; Background Art

[0002] In recent years, with the continuous development of the integration of modern medicine and traditional Chinese medicine, the application of traditional Chinese medicine in the treatment of skin diseases, especially acne, has achieved remarkable results. Acne, as a common skin problem, brings physical and psychological distress to many patients. Traditional Western medicine treatments mainly rely on topical medications or hormones. Although they are effective in the short term, they may cause problems such as drug resistance and hormone dependence. Therefore, the development of a safe, effective treatment with minimal side effects has become an important direction of medical research. Traditional Chinese medicine compound preparations, due to their multi-ingredient and multi-target characteristics, have demonstrated unique advantages in treating skin diseases such as acne. This invention, by rationally combining multiple Chinese herbal ingredients and fully leveraging the synergistic effects of traditional Chinese medicine compound preparations, aims to address the current problems of unstable efficacy and significant side effects in acne treatment. Summary of the Invention

[0003] The purpose of the present invention is to solve the above problems and design a Chinese medicine compound preparation for treating acne and a preparation method thereof; To achieve the above-mentioned purpose, the technical solution of the present invention is to provide a traditional Chinese medicine compound preparation for treating acne and a preparation method thereof, comprising 15-30 grams of forsythia suspensa, 10-20 grams of mulberry bark, 15-30 grams of dandelion, 30-60 grams of coix seed, 6-15 grams of raw ephedra, 30-60 grams of red adzuki bean, 10-30 grams of honeysuckle, 10-15 grams of sophora flavescens, 15-20 grams of patchouli, 10-15 grams of angelica dahurica, 10-15 grams of atractylodes, 3-6 grams of stevia leaf, 15-30 grams of oldenlandia diffusa, 6-15 grams of coptis chinensis, 15-30 grams of isatis indigotica, 10-15 grams of red peony root, 15-30 grams of phellodendron amurense, 30-120 grams of raw rehmannia, 30-120 grams of gypsum, and 10-15 grams of moutan bark. A method for preparing a traditional Chinese medicine compound for treating acne, comprising the following steps S1 Herbal Material Preparation: Weigh the required medicinal materials (Forsythia suspensa, Morus alba bark, Taraxacum mongolicum, Coix seed, Ephedra sinica, Adzuki bean, Honeysuckle, Sophora flavescens, Patchouli, Angelica dahurica, Atractylodes lancea, Stevia rebaudiana leaf, Hedyotis diffusa, Coptis chinensis, Isatis indigotica, Paeonia lactiflora, Phellodendron amurense, Rehmannia glutinosa, Gypsum frutescens, and Cortex moutan) according to the formula to ensure the accurate dosage of each medicinal material; S2 medicinal material processing: First, divide the herbs into two categories: one is hard herbs that need to be decocted first, such as raw earth and gypsum; the other is relatively mild herbs, such as mulberry bark and honeysuckle. Wash these herbs separately, remove impurities, dry them or cut them as needed. For raw ephedra, patchouli, etc., it is best to grind them into fine powder to facilitate the release of medicinal effects; S3 decoction method: Soak the hard herbs (such as gypsum, raw earth, red bean, etc.) in water for 2-3 hours, then put them into a large pot and boil them with water; Add an appropriate amount of water to ensure that the herbs are completely submerged in water during decoction. The recommended decoction time is 30-60 minutes to fully release the medicinal effects. During the second decoction, continue to add water and boil the herbs for 30 minutes to ensure maximum extraction of the medicinal effects; S4 Herbal Mixture: During the second decoction, add other herbs that do not require excessive decoction (such as honeysuckle, sophora flavescens, white flower snake tongue grass, moutan bark, patchouli, etc.) and continue to cook for 10-15 minutes to ensure that the medicinal effects are not over-decomposed; Combine the two decoctions and filter again to remove the residue; S5 Concentration and Drying: The decoction is concentrated to remove excess water and to an appropriate concentration. If necessary, vacuum concentration or low-temperature evaporation can be used to avoid high temperature damage to the active ingredients in the medicinal materials. The concentrated liquid is further dried to obtain the essence of the medicinal material; the drug can be made into powder or granules by using spray drying or vacuum drying techniques; S6 dosage form: The dried Chinese medicine powder or granules are further processed into tablets, capsules, granules, etc. according to the use requirements; If it is a granule, the powder can be mixed with excipients (such as starch, maltodextrin, etc.) and pressed into granules; If it is a capsule, fill the capsule according to the proportion; S7 quality inspection and packaging: Conduct quality testing on the prepared Chinese herbal compound preparations, including testing for active ingredient content, impurity content, and microbial testing, to ensure they meet relevant quality standards; After passing the test, the drugs will be packaged and labeled with relevant information such as dosage form, ingredients, and instructions for use; Furthermore, 40 grams of coix seed; Furthermore, the forsythia suspensa 20g; Furthermore, the raw earth 80 grams; Furthermore, the red peony root 10 grams; Furthermore, the Rhizoma Coptidis 10g; Furthermore, 20 grams of honeysuckle; Furthermore, 20 grams of dandelion; Furthermore, 20 grams of Hedyotis diffusa; The traditional Chinese medicine compound preparation for treating acne prepared using the technical solution of the present invention and its preparation method adopts a compound design of multiple traditional Chinese medicine ingredients, combining herbs with anti-inflammatory, antibacterial, heat-clearing and detoxifying, blood-activating and blood-stasis-removing effects, such as forsythia, dandelion, honeysuckle, and sophora flavescens. These drugs work together through multiple pathways to effectively target the multiple causes of acne (such as excessive sebaceous gland secretion, hair follicle obstruction, bacterial infection, etc.), avoiding the therapeutic limitations that may be caused by a single ingredient. The compound is rationally combined to enable the various ingredients to interact and complement each other; for example, forsythia and honeysuckle have the effect of clearing heat and detoxifying, which helps to inhibit acne caused by internal heat; while raw ephedra and coix seed help to promote diuresis and reduce swelling, reducing the inflammatory response of acne; the overall compound improves the stability of the therapeutic effect through the synergistic effect of the drugs. Unlike traditional treatments, this technology uses a highly targeted Chinese medicine formula that addresses multiple aspects of acne formation, such as clearing away heat and detoxifying, reducing swelling and relieving pain, and promoting blood circulation and removing blood stasis. The targeted effects of different medicinal ingredients can better regulate the body's damp and hot environment and reduce the occurrence of acne. DETAILED DESCRIPTION

[0004] The present invention is described in detail below, a Chinese medicinal compound preparation for treating acne and a preparation method thereof; Example 1 A traditional Chinese medicine compound preparation for treating acne, comprising 15-30 grams of forsythia, 10-20 grams of mulberry bark, 15-30 grams of dandelion, 30-60 grams of coix seed, 6-15 grams of raw ephedra, 30-60 grams of red bean, 10-30 grams of honeysuckle, 10-15 grams of sophora flavescens, 15-20 grams of patchouli, 10-15 grams of angelica dahurica, 10-15 grams of atractylodes, 3-6 grams of stevia leaf, 15-30 grams of oldenlandia diffusa, 6-15 grams of coptis chinensis, 15-30 grams of isatis indigotica, 10-15 grams of red peony root, 15-30 grams of phellodendron amurense, 30-120 grams of raw rehmannia, 30-120 grams of gypsum, and 10-15 grams of moutan bark. Example 2 A method for preparing a traditional Chinese medicine compound for treating acne, comprising the following steps: S1 Preparation of medicinal materials Weigh the required medicinal materials (Forsythia suspensa, Morus alba bark, Taraxacum mongolicum, Coix seed, Ephedra sinica, Adzuki bean, Honeysuckle, Sophora flavescens, Patchouli, Angelica dahurica, Atractylodes lancea, Stevia rebaudiana leaf, Hedyotis diffusa, Coptis chinensis, Isatis indigotica, Paeonia lactiflora, Phellodendron amurense, Rehmannia glutinosa, Gypsum frutescens, and Cortex moutan) according to the formula to ensure the accurate dosage of each medicinal material; S2 medicinal material processing: First, divide the herbs into two categories: one is hard herbs that need to be decocted first, such as raw earth and gypsum; the other is relatively mild herbs, such as mulberry bark and honeysuckle. Wash these herbs separately, remove impurities, dry them or cut them as needed. For raw ephedra, patchouli, etc., it is best to grind them into fine powder to facilitate the release of medicinal effects; S3 decoction method: Soak the hard herbs (such as gypsum, raw earth, red bean, etc.) in water for 2-3 hours, then put them into a large pot and boil them with water; Add an appropriate amount of water to ensure that the herbs are completely submerged in water during decoction. The recommended decoction time is 30-60 minutes to fully release the medicinal effects. During the second decoction, continue to add water and boil the herbs for 30 minutes to ensure maximum extraction of the medicinal effects; S4 Herbal Mixture: During the second decoction, add other herbs that do not require excessive decoction (such as honeysuckle, sophora flavescens, white flower snake tongue grass, moutan bark, patchouli, etc.) and continue to cook for 10-15 minutes to ensure that the medicinal effects are not over-decomposed; Combine the two decoctions and filter again to remove the residue; S5 Concentration and Drying: The decoction is concentrated to remove excess water and to an appropriate concentration. If necessary, vacuum concentration or low-temperature evaporation can be used to avoid high temperature damage to the active ingredients in the medicinal materials. The concentrated liquid is further dried to obtain the essence of the medicinal material; the drug can be made into powder or granules by using spray drying or vacuum drying techniques; S6 dosage form: The dried Chinese medicine powder or granules are further processed into tablets, capsules, granules, etc. according to the use requirements; If it is a granule, the powder can be mixed with excipients (such as starch, maltodextrin, etc.) and pressed into granules; If it is a capsule, fill the capsule according to the proportion; S7 quality inspection and packaging: Conduct quality testing on the prepared Chinese herbal compound preparations, including testing for active ingredient content, impurity content, and microbial testing, to ensure they meet relevant quality standards; After passing the test, the drugs will be packaged and labeled with relevant information such as dosage form, ingredients, and instructions for use; The above technical solutions only reflect the preferred technical solutions of the technical solutions of the present invention. Any changes that may be made to certain parts thereof by those skilled in the art all reflect the principles of the present invention and fall within the scope of protection of the present invention.

Claims

1. A Chinese medicinal compound preparation for treating acne, characterized in that: Including 15-30 grams of Forsythia suspensa, 10-20 grams of Morus alba bark, 15-30 grams of Taraxacum mongolicum, 30-60 grams of Coix seed, 6-15 grams of raw ephedra, 30-60 grams of red bean, 10-30 grams of honeysuckle, 10-15 grams of Sophora flavescens, 15-20 grams of Patchouli, 10-15 grams of Angelica dahurica, 10-15 grams of Atractylodes macrocephala, 3-6 grams of Stevia leaf, 15-30 grams of Hedyotis diffusa, 6-15 grams of Coptis chinensis, 15-30 grams of Isatis indigotica, 10-15 grams of red peony root, 15-30 grams of Phellodendron chinense, 30-120 grams of Rehmannia glutinosa, 30-120 grams of Gypsum, and 10-15 grams of Cortex Moutan.

2. A method for preparing a traditional Chinese medicine compound for treating acne, characterized in that: The following steps are included: S1 Herbal Material Preparation: Weigh the required medicinal materials (Forsythia suspensa, Morus alba bark, Taraxacum mongolicum, Coix seed, Ephedra sinica, Adzuki bean, Honeysuckle, Sophora flavescens, Patchouli, Angelica dahurica, Atractylodes lancea, Stevia rebaudiana leaf, Hedyotis diffusa, Coptis chinensis, Isatis indigotica, Paeonia lactiflora, Phellodendron amurense, Rehmannia glutinosa, Gypsum frutescens, and Cortex moutan) according to the formula to ensure the accurate dosage of each medicinal material; S2 medicinal material processing: First, divide the herbs into two categories: one is hard herbs that need to be decocted first, such as raw earth and gypsum; the other is relatively mild herbs, such as mulberry bark and honeysuckle. Wash these herbs separately, remove impurities, dry them or cut them as needed. For raw ephedra, patchouli, etc., it is best to grind them into fine powder to facilitate the release of medicinal effects; S3 decoction method: Soak the hard herbs (such as gypsum, raw earth, red bean, etc.) in water for 2-3 hours, then put them into a large pot and boil them with water; Add an appropriate amount of water to ensure that the herbs are completely submerged in water during decoction. The recommended decoction time is 30-60 minutes to fully release the medicinal effects. During the second decoction, continue to add water and boil the herbs for 30 minutes to ensure maximum extraction of the medicinal effects; S4 Herbal Mixture: During the second decoction, add other herbs that do not require excessive decoction (such as honeysuckle, sophora flavescens, white flower snake tongue grass, moutan bark, patchouli, etc.) and continue to cook for 10-15 minutes to ensure that the medicinal effects are not over-decomposed; Combine the two decoctions and filter again to remove the residue; S5 Concentration and Drying: The decoction is concentrated to remove excess water and to an appropriate concentration. If necessary, vacuum concentration or low-temperature evaporation can be used to avoid high temperature damage to the active ingredients in the medicinal materials. The concentrated liquid is further dried to obtain the essence of the medicinal material; the drug can be made into powder or granules by using spray drying or vacuum drying techniques; S6 dosage form: The dried Chinese medicine powder or granules are further processed into tablets, capsules, granules, etc. according to the use requirements; If it is a granule, the powder can be mixed with excipients (such as starch, maltodextrin, etc.) and pressed into granules; If it is a capsule, fill the capsule according to the proportion; S7 quality inspection and packaging: Conduct quality testing on the prepared Chinese herbal compound preparations, including testing for active ingredient content, impurity content, and microbial testing, to ensure they meet relevant quality standards; After passing the test, the medicines will be packaged and labeled with relevant information such as dosage form, ingredients, and instructions for use.

3. A Chinese medicinal compound preparation for treating acne according to claim 1, characterized in that: 40 grams of coix seed.

4. A Chinese medicinal compound preparation for treating acne according to claim 1, characterized in that: The forsythia suspensa is 20 grams.

5. A Chinese medicinal compound preparation for treating acne according to claim 1, characterized in that: The raw land is 80 grams.

6. A Chinese medicinal compound preparation for treating acne according to claim 1, characterized in that: 10 grams of red peony root.

7. A Chinese medicinal compound preparation for treating acne according to claim 1, characterized in that: 10 grams of Coptis chinensis.

8. A Chinese medicinal compound preparation for treating acne according to claim 1, characterized in that: 20 grams of the honeysuckle.

9. A Chinese medicinal compound preparation for treating acne according to claim 1, characterized in that: The dandelion is 20 grams.

10. A Chinese medicinal compound preparation for treating acne according to claim 1, characterized in that: 20 grams of the herb.