Substituted propionate compound as well as preparation method, pharmaceutical composition and application thereof
By developing substituted propionate compounds, the efficacy ceiling and adverse reaction problems of NSAIDs in the treatment of moderate to severe pain and inflammation have been resolved, providing new NSAIDs options, achieving effective treatment and prevention of inflammation, pain and fever, and being suitable for a variety of administration methods and diseases.
Patent Information
- Application Number
- CN202410338035.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-03-22
- Publication Date
- 2025-09-23
AI Technical Summary
Existing nonsteroidal anti-inflammatory drugs (NSAIDs) have a ceiling effect in the treatment of moderate to severe pain, inflammation, and cardiovascular and cerebrovascular diseases. They may cause gastrointestinal bleeding, perforation, and other serious adverse reactions. In addition, there is a lack of breakthroughs in new drugs, and they cannot meet the increasing clinical needs.
A substituted propionate compound has been developed that inhibits cyclooxygenase (COX) to hinder the conversion of arachidonic acid into prostaglandins and thromboxanes. It has good anti-inflammatory activity and is used to prepare a pharmaceutical composition to treat and prevent symptoms such as inflammation, pain, and fever.
This compound effectively treats and prevents inflammation, pain, and fever, reduces adverse reactions, and provides a new NSAIDs option. It is suitable for multiple administration methods, including oral, sublingual, parenteral, transdermal, and inhalation, and is suitable for a variety of diseases such as rheumatoid arthritis and osteoarthritis.
Smart Images
Figure CN120682211A_ABST