Experimental animal remote monitoring and data management system

Abstract

The invention relates to the field of experimental animal supervision, in particular to an experimental animal remote monitoring and data management system which comprises a process management subsystem, a cage position management subsystem, an order and feeding management subsystem, an environment monitoring subsystem, a server side and a user side. Each rearing cage is provided with a data acquisition module, and each data acquisition module comprises a smell sensor used for monitoring the smell of the rearing cage and a weight sensor used for monitoring the internal weight of the rearing cage. And the server carries out comparison judgment according to the smell information collected by the smell sensor and a threshold value. The invention aims to realize automation and informatization of the whole process of experimental animals from ethical examination and approval to feeding management, environment monitoring and data analysis, and improve the accuracy and efficiency of experimental animal management.

Description

Technical Field

[0001] The present invention relates to the field of laboratory animal supervision, and in particular to a laboratory animal remote monitoring and data management system. Background Art

[0002] In the field of laboratory animal research, efficient and accurate management of laboratory animals is crucial for the accuracy and reliability of experimental results. Traditional management methods often rely on manual record-keeping and physical identification, such as handwritten logs and paper labels. These methods are not only inefficient but also prone to errors, failing to meet the requirements of modern laboratory animal research for efficient, accurate, and safe management. Advances in science and technology, particularly the rapid development of information technology and sensor technology, have provided new solutions for laboratory animal management.

[0003] However, while some existing laboratory animal management systems have emerged, most of these systems are limited in functionality, primarily focusing on cage management, order processing, or data tracking. They fail to fully automate and inform the entire process, from ethical approval to animal husbandry, environmental monitoring, and data analysis. Furthermore, these systems suffer from confusing cage management and inconvenient application processes, cumbersome and opaque order processing, and severely inadequate data tracking and identification methods. These systems fail to meet the comprehensive requirements of modern laboratory animal research for efficient, accurate, safe, and information-based management.

[0004] Specifically, the existing system often lacks standardization and automation in terms of ethical approval, and the approval process is cumbersome and error-prone, which affects the welfare and ethical compliance of experimental animals. In terms of cage management, there is a lack of flexible and diverse application methods, cage resource allocation is unreasonable, utilization is low, and the number of free cages cannot be displayed in real time, resulting in waste of resources. In terms of order and feeding management, there is a lack of convenient and efficient purchasing and order processing mechanisms, cost calculation is not transparent, order processing efficiency is low, and it is impossible to effectively receive and process feedback from suppliers. In terms of environmental monitoring, there is a lack of real-time monitoring and alarm means, and it is impossible to detect problems in the feeding environment in a timely manner to ensure the health of experimental animals. At the same time, the existing system also lacks data analysis and report generation functions, and cannot provide experimental personnel with a scientific basis for optimizing experimental design and feeding management.

[0005] Therefore, in order to solve the above problems, the present invention proposes a remote monitoring and data management system for experimental animals. Summary of the Invention

[0006] To solve the above problems, the present invention provides a remote monitoring and data management system for experimental animals, which aims to realize the automation and informatization of the entire process of experimental animals from ethical approval to feeding management, environmental monitoring and data analysis, improve the accuracy and efficiency of experimental animal management, ensure the welfare and ethical compliance of experimental animals, optimize cage resource allocation, improve cage utilization, simplify order processing procedures, improve order processing efficiency, enhance data tracking and identification capabilities, timely discover feeding environment problems, and provide scientific basis for experimenters to optimize experimental design and feeding management.

[0007] To achieve the above-mentioned purpose, the technical solution of the present invention is as follows: a remote monitoring and data management system for experimental animals, comprising a process management subsystem for experimental animal ethics approval, a cage management subsystem for experimental animal cage application and management, an order and feeding management subsystem for experimental animal purchase and feeding, an environmental monitoring subsystem for experimental animal environmental monitoring and alarm, a server for processing experimental animal data, and several user terminals for accessing and operating data. The process management subsystem, the cage management subsystem, the order and feeding management subsystem, and the environmental monitoring subsystem are all signal-connected to the server and the user terminals. The environmental monitoring subsystem includes a feeding rack on which several feeding cages are detachably mounted. Each feeding cage is equipped with a data acquisition module. The data acquisition module includes an odor sensor for monitoring the odor of the feeding cage and a weight sensor for monitoring the internal weight of the feeding cage. When the feeding cage is on the feeding rack and the experimental animal is in the feeding cage, the odor information in the feeding cage collected by the odor sensor is marked as the first odor information; when the server determines that the experimental animal has left the feeding cage based on the weight information monitored in real time by the weight sensor, the real-time odor information in the feeding cage collected by the odor sensor at this time is marked as the second odor information; when the experimental animal returns to the feeding cage, the odor information in the feeding cage collected by the odor sensor again is marked as the third odor information; when the feeding cage is placed back on the feeding rack, the odor information collected by the odor sensor is marked as the fourth odor information; When the server compares the first odor information with the fourth odor information, if the comparison result is less than a preset comparison threshold, it is determined that the breeding cage is returned to the breeding rack and the return position is correct; When the server compares the second odor information with a preset odor information threshold, if the second odor information is less than the odor information threshold, it is determined that the distance between the breeding cage and the experimental animal exceeds the preset range, and the server notifies the experimenter through the user terminal; When the server compares the third odor information with the second odor information, if the third odor information is the same as the second odor information and the weight information monitored in real time by the weight sensor remains unchanged, it is determined that the experimental animal is correctly matched with the breeding cage.

[0008] Furthermore, the process management subsystem includes an automatic saving module for automatically saving application information for experimental animal ethics approval; a preliminary review module for performing routine error checks on application information; a review module for supporting review of individual entries; a modification trace module for recording modifications during the approval process and highlighting the modifications; and a review module for specifying review experts to review or setting a threshold to enable multiple experts to review.

[0009] Furthermore, the cage management subsystem includes an instant application module for applying for cage spaces immediately; a queuing reservation module for reserving cage spaces and queuing in order; a cage application module for applying for fixed cage spaces; an idle cage display module for publicly displaying the number of idle cage spaces; a feeding application designation module for specifying cage spaces when applying for feeding; and a cage restriction module for limiting the number of cage spaces according to research groups or units.

[0010] Furthermore, the order and breeding management subsystem includes a shopping cart module for users to operate in a shopping cart manner and purchase experimental animals; a cost calculation module for calculating and counting transportation costs, packaging costs and management fees; an order sending module for sending orders to suppliers with one click; a supplier feedback module for receiving direct feedback from suppliers; an animal receiving module for solving experimental animal reception problems; and a self-breeding animal management module for supporting the sale, inventory display and transfer of self-breeding animals to external suppliers.

[0011] Furthermore, the data acquisition module also includes a temperature sensor for monitoring the temperature in the breeding cage and a humidity sensor for monitoring the humidity in the breeding cage. Both the temperature sensor and the humidity sensor are connected to the server signal. The server issues an over-limit alarm based on the data collected by the temperature sensor and the humidity sensor, and pushes the alarm information through the user end.

[0012] Furthermore, the data acquisition module also includes an RFID reader. An RFID tag is installed on the breeding cage. The RFID reader is used to read the information of the RFID tag on the breeding cage. The information of the RFID tag is used to track and identify the breeding cage and the experimental animals therein.

[0013] Furthermore, the environmental monitoring subsystem also includes a docking module, which is used to dock with the independent ventilation cage host and read the temperature, humidity, pressure difference and air supply data, issue an over-limit alarm, and push the alarm information through the user terminal.

[0014] Furthermore, the server includes a data analysis module, which is used to analyze the experimental animal data uploaded by the user and generate an analysis report on the health status of the experimental animals and the breeding environment.

[0015] Furthermore, the user end includes PC, mobile and large-screen display ends, and the user end is used to support multi-platform access and operation of data.

[0016] Furthermore, it also includes a facility management subsystem, which is used to manage the experimental animal center's infrastructure, facility permissions, entry and exit rules, breeding racks and breeding cages, and the facility management subsystem signal is connected to the access control subsystem, which is used for security management of the experimental animal center.

[0017] The technical principle of the above scheme is as follows: The experimental animal remote monitoring and data management system of the present invention integrates multiple key subsystems, aiming to realize the automation and informatization of the entire process of experimental animals, from ethical approval to feeding management, environmental monitoring and data analysis. The real-time transmission and processing of data between the subsystems are realized through the server and user ends.

[0018] The process management subsystem automates the ethical approval process for experimental animals, from application information storage, initial review, review, modification record keeping, to re-review, ensuring a standardized and efficient approval process. The cage management subsystem offers multiple application methods, including instant cage application, reservation, and cage reservation. It also displays available cages and limits cage availability to meet diverse experimental needs. Users of the order and husbandry management subsystem can purchase experimental animals through a shopping cart. The system automatically calculates costs and sends orders to suppliers. The system also supports animal reception and the management of self-breeding animals. The environmental monitoring subsystem uses data acquisition modules on the cages to monitor the husbandry environment (such as odor, weight, temperature, and humidity) in real time, comparing data with the server and processing alarms. The system can also connect to independent ventilation cage hosts to retrieve relevant environmental data.

[0019] The above scheme has the following beneficial effects: 1. This solution uses odor sensors to collect odor information in the cage and marks and compares it according to different situations (such as when the experimental animal is in the cage, when it leaves the cage, when it returns to the cage, and when the cage is returned). Compared with the existing technology that relies solely on physical identification or manual recording, this solution helps to more accurately and automatically judge the status of the cage, the movement of experimental animals, and the return of the cage, thereby improving the accuracy and efficiency of experimental animal management.

[0020] 2. In this solution, the process management subsystem includes multiple modules such as automatic saving, preliminary review, review, modification record keeping, and re-review. Compared with the cumbersome and error-prone approval process in existing technologies, this solution helps to automate and standardize the ethical approval of experimental animals, improves the efficiency and accuracy of approval, and also helps to improve the welfare and ethical compliance of experimental animals.

[0021] 3. In this solution, the cage management subsystem provides a variety of cage application methods, including immediate application, queue reservation, and cage-package application. Compared with the existing technology with chaotic cage management and inconvenient application, this solution meets the needs of different experiments, helps to optimize cage resource allocation, and improves cage utilization. At the same time, the idle cage display module and cage restriction module also help to optimize cage management and avoid resource waste.

[0022] 4. In this solution, the order and breeding management subsystem supports the purchase of experimental animals in a shopping cart manner, calculates and counts costs, sends orders with one click, and receives supplier feedback. Compared with the existing technology with cumbersome order processing and information opacity, this solution helps to simplify the order processing process, improve order processing efficiency, and at the same time ensure information transparency and traceability.

[0023] 5. In this solution, the data acquisition module also includes a temperature sensor, a humidity sensor, and an RFID reader, which can monitor the environmental parameters and cage information in the cage in real time, and perform over-limit alarms and tracking and identification. Compared with the problem of insufficient environmental monitoring and tracking means in the existing technology, this solution helps to timely discover problems in the breeding environment, ensure the health of experimental animals, and at the same time improve the tracking and identification capabilities of the cages and experimental animals.

[0024] 6. In this solution, the server-side data analysis module analyzes experimental animal data and generates reports on health status and feeding environment. This provides a scientific basis for experimenters and helps optimize experimental design and feeding management. Furthermore, the client-side supports multi-platform access and manipulation of data, improving the convenience and flexibility of data management. Furthermore, the addition of a facility management subsystem and access control subsystem further enhances the safety and management of the laboratory animal center.

[0025] Additional aspects and advantages of the present invention will be set forth in part in the description which follows and, in part, will be obvious from the description which follows, or may be learned by practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 This is a framework diagram of an embodiment of the experimental animal remote monitoring and data management system of the present invention; Figure 2 This is a flow chart of an embodiment of the experimental animal remote monitoring and data management system of the present invention; Figure 3 This is a hardware topology diagram of an embodiment of the experimental animal remote monitoring and data management system of the present invention. DETAILED DESCRIPTION

[0027] The technical solution of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention without making any creative efforts shall fall within the scope of protection of the present invention.

[0028] In the description of the present invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings and are intended solely to facilitate and simplify the description of the present invention. They are not intended to indicate or imply that the devices or components referred to must have, be constructed, or operate in a specific orientation, and therefore should not be construed as limitations on the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0029] The following is further described in detail through specific implementation methods: Example 1:

[0030] As attached Figures 1 to 3 The system depicts a remote monitoring and data management system for experimental animals, including a process management subsystem for ethical approval of experimental animals, a cage management subsystem for cage application and management of experimental animal cages, an order and feeding management subsystem for purchasing and feeding experimental animals, an environmental monitoring subsystem for environmental monitoring and alarms, a server for processing experimental animal data, and several client terminals for accessing and manipulating data. The process management subsystem, cage management subsystem, order and feeding management subsystem, and environmental monitoring subsystem are all connected to the server and client terminals, enabling remote access and manipulation of data through these terminals. The server terminal includes a data analysis module that analyzes experimental animal data uploaded by the client terminals and generates reports analyzing the animal's health status and feeding environment. The client terminals include PCs, mobile terminals (such as smartphones and tablets), and large-screen display terminals. These terminals support multi-platform access and manipulation of data, allowing different roles to access different modules and implement permission management.

[0031] The process management subsystem includes an automatic saving module for automatically saving application information for experimental animal ethics approval to ensure the integrity and traceability of the data; a preliminary review module for performing routine error checks on application information to preliminarily screen out applications that do not meet the requirements; a review module for supporting the review of individual entries to facilitate reviewers to quickly understand the application content; a modification trace module for recording modifications during the approval process and highlighting the modifications to ensure the transparency and fairness of the approval process; and a review module for designating review experts to review or setting thresholds for multiple expert reviews to improve the accuracy and reliability of approvals.

[0032] The cage management subsystem includes an instant application module for applying for cage spaces immediately to meet urgent experimental needs; a queuing reservation module for reserving cage spaces and queuing in order to reasonably allocate resources; a cage application module for applying for fixed cage spaces to meet long-term experimental needs; an idle cage display module for publicly displaying the number of idle cages; a feeding application designation module for specifying cage spaces when applying for feeding; and a cage restriction module for limiting the number of cages according to research groups or units.

[0033] The order and breeding management subsystem includes a shopping cart module for users to operate in a shopping cart manner and purchase experimental animals; a cost calculation module for calculating and counting transportation fees, packaging fees, and management fees; an order sending module for sending orders to suppliers with one click; a supplier feedback module for receiving direct feedback from suppliers; an animal receiving module for solving problems in receiving experimental animals; and a self-breeding animal management module for supporting the sales, inventory display, and transfer of self-bred animals to external suppliers. It supports shopping cart operation and is easy to use; supports self-settlement and system settlement; supports multiple cost calculations (such as transportation fees, packaging fees, management fees, etc.); sends orders to suppliers with one click for fast procurement. It also provides the function of recording experimental information online to reduce manual work; supports cage position verification, cage arrangement, and other operations; supports animal handling, breeding, cage separation, cage transfer, identification, and other operations; supports cage box bedding replacement, cage disinfection, and other operation registration, The environmental monitoring subsystem includes a breeding rack with several removable cages mounted on it. Each cage is equipped with a data acquisition module, which includes an odor sensor for monitoring the cage's odor and a weight sensor for monitoring the cage's internal weight. The data acquisition module also includes a temperature sensor for monitoring the temperature within the cage and a humidity sensor for monitoring the humidity within the cage. Both the temperature sensor and the humidity sensor are connected to the server. The server issues an over-limit alarm based on the data collected by the temperature and humidity sensors, and pushes the alarm information to the user end. The alarm can be sent via email, SMS, WeChat, and mobile devices.

[0034] When the feeding cage is on the feeding rack and the experimental animal is in the feeding cage, the odor information in the feeding cage collected by the odor sensor is marked as the first odor information; when the server determines that the experimental animal has left the feeding cage based on the weight information monitored in real time by the weight sensor, the real-time odor information in the feeding cage collected by the odor sensor at this time is marked as the second odor information; when the experimental animal returns to the feeding cage, the odor information in the feeding cage collected by the odor sensor again is marked as the third odor information; when the feeding cage is placed back on the feeding rack, the odor information collected by the odor sensor is marked as the fourth odor information.

[0035] When the server compares the first odor information with the fourth odor information, if the comparison result is less than the preset comparison threshold, it is judged that the breeding cage is returned to the breeding rack and the return position is correct; when the server compares the second odor information with the preset odor information threshold, if the second odor information is less than the odor information threshold, it is judged that the distance between the breeding cage and the experimental animal exceeds the preset range, and the server notifies the experimenter through the user terminal; when the server compares the third odor information with the second odor information, if the third odor information and the second odor information are the same, and the weight information monitored in real time by the weight sensor remains unchanged, it is judged that the experimental animal and the breeding cage are correctly matched.

[0036] The specific implementation process is as follows: 1. Experimental Animal Ethics Approval (Process Management Subsystem) Application Submission: Experimenters submit applications for ethical review of experimental animal use through the user's PC or mobile app. When submitting an application, they must provide detailed information on the experimental background, purpose, expected outcomes, specific information on the experimental animals (species, number, age, sex, and health status), and experimental methods (including experimental procedures, anesthesia and analgesia methods, and methods of sacrifice). After submitting the application, an automatic save module immediately stores the application information on the server to ensure data security and integrity. The system also generates a unique application number for easy follow-up and tracking.

[0037] Initial Review: The initial review module performs routine error checks on the application information, including but not limited to completeness, logic, and compliance with experimental methods. If the application information is found to be incomplete or contains obvious errors, the initial review module will automatically generate feedback and send it to the experimenter through the user terminal to guide them in making revisions and improvements. After receiving the feedback, the experimenter can modify the application information based on the feedback and resubmit it.

[0038] Review and Modification: Approval personnel review application content (including the rationality of experimental design and ethical compliance) through the review module and make approval decisions. If modifications are required, the reviewer can mark them directly in the system. The modification trace module records and highlights each modification, ensuring the transparency and fairness of the approval process. Experimenters can make further modifications based on the reviewer's comments and resubmit the application.

[0039] Review: The review module conducts a review based on set passing thresholds (such as reviewer scores and consensus) or designated review experts. If the application passes the review, the system automatically generates an ethics approval certificate and sends it to the experimenter via the user interface. This certificate is also stored in the system for easy access and verification. If the application fails the review, the system automatically generates feedback and provides the experimenter with recommended next steps.

[0040] For example, researcher Zhang San submitted an application for a metabolic experiment on mice. After preliminary review, review, modification and re-review, he finally obtained an ethical approval certificate.

[0041] 2. Cage Application and Management (Cage Management Subsystem) Cage Space Request: Based on experimental needs, researchers can quickly request a free cage space using the Instant Application module. For long-term experiments, researchers can use the Queue Reservation module to reserve a cage space, with the system allocating cage spaces based on the order of reservations. For experiments requiring long-term cage space, researchers can request a fixed cage space using the Cage Space Request module, with the system allocating cage spaces based on information in the Cage Space Restriction module (e.g., research group, institution, and experiment type).

[0042] Cage Allocation: The cage management subsystem updates cage occupancy status in real time based on information in the free cage display module. Based on the experimenter's application information and the settings in the cage restriction module, the system automatically assigns a suitable cage to the experimenter. The experimenter can view and confirm the assigned cage information in the breeding application designation module.

[0043] Feeding Application: After confirming the cage allocation, the experimenter needs to fill in the feeding application information in the designated feeding application module, including the type, number, and feeding cycle of the experimental animals. The system will generate a feeding plan based on the feeding application information and notify the experimenter to conduct the feeding experiment according to the plan.

[0044] For example, experimenter Zhang San applied for a ready-to-use cage for a mouse breeding experiment.

[0045] 3. Purchase and breeding of experimental animals (order and breeding management subsystem) Purchasing Laboratory Animals: Experimenters can browse and purchase the required laboratory animals through the shopping cart module. The system will filter and display the animals based on their species, quantity, age, and gender. Experimenters can add the selected laboratory animals to the shopping cart and view the product details and total price.

[0046] Cost Calculation and Settlement: The cost calculation module automatically calculates transportation, packaging, and administrative fees based on factors such as the type and quantity of experimental animals, transportation distance, and packaging requirements. Experimenters can choose to settle their expenses either on their own or through the system. If they choose system settlement, the system automatically deducts payment based on their payment information. If they choose to settle their expenses on their own, they must settle with the supplier according to the system-generated expense list.

[0047] Order Submission and Receipt: The order submission module allows researchers to send orders to suppliers with a single click. The system then generates an order details page, including the order number, laboratory animal information, and a cost list. The supplier feedback module receives direct, real-time feedback from suppliers, including order status (received, shipped, delivered, etc.), shipping time, and estimated arrival time. The animal receiving module records the receipt of laboratory animals, including the time of receipt, receiving personnel, and the animal's condition. If any issues arise during the animal receiving process (such as inconsistent numbers or poor health), researchers can use this module to provide feedback and address the issue.

[0048] Animal Husbandry and Management: Experimenters can record experimental information online in the system, such as mouse feeding records (feeding times, water intake, and weight changes) and health status (disease status and treatment records). The system supports cage verification, allowing real-time monitoring of cage occupancy and animal husbandry status. Experimenters can use the system to perform cage organization operations, such as adjusting cage positions and replacing cage boxes. The system also supports operations such as animal handling (e.g., sacrifice and euthanasia), breeding (e.g., mating plans and breeding records), cage separation and transfer (e.g., grouping and cage relocation), and identification (e.g., genotyping and phenotyping).

[0049] For example, researcher Zhang San purchased 10 mice using the shopping cart module and selected the system to check out. After submitting the order, the supplier quickly provided shipping information. After the mice arrived, researcher Zhang San handled the receipt process using the animal receiving module and began the breeding experiment.

[0050] 4. Environmental monitoring and alarm (environmental monitoring subsystem) The data acquisition module monitors the cage's odor, weight, temperature, and humidity in real time, and uploads the data to the server for processing and analysis. The server then determines if an over-limit alarm is triggered based on preset thresholds (such as temperature and humidity ranges). When the temperature or humidity exceeds a preset threshold, the server issues an alarm and pushes the alarm to the user (via email, SMS, WeChat, or mobile device; experimenters can choose the appropriate alarm method based on their needs). The experimenter then receives the alarm and takes appropriate action.

[0051] When the breeding cage is on the breeding rack, the server marks the odor information collected by the odor sensor as the first odor information; when the experimental animal leaves the breeding cage, it is marked as the second odor information; when the experimental animal returns to the breeding cage, it is marked as the third odor information; when the breeding cage is placed back on the breeding rack, it is marked as the fourth odor information.

[0052] By comparing the first and fourth odor information, the correct cage is determined. If the two differ significantly, it may indicate that the cage has been misplaced or mixed up. By comparing the second odor information with a preset odor threshold, the distance between the cage and the experimental animal is determined to be outside the preset range. If the second odor information is weak or undetectable, it may indicate that the experimental animal has been away from the cage for an extended period of time or at a great distance. By comparing the third and second odor information, the correct match between the experimental animal and the cage is determined. If the two are highly similar, it may indicate that the experimental animal has been correctly returned to the cage.

[0053] For example, during a feeding experiment, the temperature inside a cage exceeded a preset threshold (e.g., 30°C). The server immediately sent an alert to experimenter Zhang San via email and text message. Zhang San quickly took cooling measures (e.g., turning on the air conditioner, adjusting the cage's position), ensuring a safe feeding environment for the mice.

[0054] In addition, during a cage reorganization, experimenter Zhang San moved a cage to another cage rack. Using the odor information comparison function, the server determined that the cage was returned to the incorrect location and notified experimenter Zhang San to correct it.

[0055] In summary, this remote monitoring and data management system for experimental animals allows researchers to more efficiently and safely handle tasks such as ethical approval, cage application and management, purchase and breeding of experimental animals, and environmental monitoring and alarming, providing strong support for scientific research.

[0056] Example 2:

[0057] The difference from Example 1 is that the data acquisition module also includes an RFID reader (RFID (Radio Frequency Identification) technology is a contactless automatic identification technology that uses radio frequency signals and their spatial coupling and transmission characteristics to automatically identify stationary or moving objects). The cages are equipped with RFID tags that store key information such as the cage number, the type and number of experimental animals, and the breeding cycle. The RFID reader is used to read the information on the RFID tags on the cages, which is used to track and identify the cages and the experimental animals therein.

[0058] The specific implementation process is as follows: During the cage manufacturing or assembly process, RFID tags are embedded or attached to the cage in a conspicuous and non-destructive location. Each RFID tag is initialized, with basic cage information such as cage number, size, and material entered, and a unique identifier (UID) assigned. The experimental animal's information (species, number, experimental project, etc.) is associated with the cage's RFID tag to ensure accuracy and consistency. RFID readers are installed at the entrance, exit, or specific area of ​​the cage, ensuring that the reader covers all cages that need to be tracked. The reader's parameters, such as RF frequency, read range, and read speed, are configured to ensure accurate and rapid reading of tag information.

[0059] When a cage passes through the coverage area of ​​an RFID reader, the reader transmits a radio frequency signal and receives the reflected signal from the RFID tag. The reader interprets the information in the tag and transmits it to the server for processing and analysis. The server updates the cage and animal tracking records based on this information and displays them in real time in the system.

[0060] The system uses RFID technology to track and identify cages and the experimental animals within them in real time. Experimenters can view information such as the cage's current location, historical location, and the animal's feeding status. If any anomalies occur with the cage or the experimental animals (such as loss or mix-up), the system immediately issues an alarm and prompts the experimenter to address the situation. For example, consider a cage used for a mouse metabolic experiment. During manufacture, the cage is embedded with an RFID tag and initialized with cage number "001," stainless steel material, and dimensions of "L x W x H = 50 cm x 30 cm x 20 cm." Before the experiment begins, the cage's RFID tag is associated with the experimental project, "Mouse Metabolic Experiment," and the experimental animal information (species: mouse, number: 10).

[0061] An RFID reader was deployed at the entrance to the cages in the feeding area, configured with a read range of 50 cm, a read frequency of once per second, and a wireless LAN data transmission method. When a mouse in cage "001" entered the cage, the reader automatically read the RFID tag and transmitted the data to the server.

[0062] After receiving the RFID tag information from cage "001," the server interprets the cage number as "001," the experimental animals as "mice," and the number as "10." Based on this information, the server updates the occupancy status of cage "001" to "occupied" and records the mice's feeding history. The server also determines whether the cage has been returned correctly by comparing the return location with the odor information. If the cage is returned incorrectly, the server immediately triggers an alarm, notifying the experimenter to correct the situation.

[0063] During a cage relocation process, an experimenter mistakenly placed cage "001" on a different cage rack. The server compared the RFID tag information on cage "001" with the preset cage location information, determining that it had been returned to the incorrect location and immediately triggering an alarm. After receiving the alarm, experimenter Zhang San quickly followed the system's instructions to locate cage "001" and reposition it on the correct rack.

[0064] Example 3:

[0065] The difference from Example 2 is that the environmental monitoring subsystem also includes a docking module, which is used to dock with the independent ventilation cage host (IVC) and read the temperature, humidity, pressure difference and air supply data, issue an over-limit alarm, and push the alarm information through the user terminal.

[0066] The specific implementation process is as follows: Physically connect the docking module to the independent ventilation cage host, configure communication parameters, and verify the interface's communication and data parsing accuracy by sending test data or simulated data. Code is written within the docking module to read real-time data from the independent ventilation cage host and display this data on the user interface, allowing users to understand the cage's environmental conditions in real time.

[0067] Set alarm thresholds for parameters such as temperature, humidity, differential pressure, and air flow in the system. For example, you can set normal ranges for temperature to 20-25°C, humidity to 40%-60%, differential pressure to ±5Pa, and air flow to XXm³ / h. Once data exceeds these ranges, an alarm is triggered.

[0068] When an alarm is triggered, the docking module encapsulates and processes the alarm information (including alarm type, alarm time, and alarm value). This information is then pushed to the user via a pre-defined push method (such as SMS, email, or instant messaging). Alarm history information is also recorded in the system for subsequent analysis and processing.

[0069] Example 4:

[0070] The difference from Example 3 is that it also includes a facility management subsystem, which is used to manage the infrastructure, facility permissions, entry and exit rules, breeding racks and breeding cages of the experimental animal center, and the facility management subsystem signal is connected to the access control subsystem, which is used for security management of the experimental animal center.

[0071] The specific implementation process is as follows: 1. Facilities Management Subsystem Record all infrastructure information for the laboratory animal center, such as housing racks, cages, ventilation equipment, and temperature and humidity control systems, including equipment number, location, model, manufacturer, and maintenance records. Use sensors or manual inspections to monitor the operational status of infrastructure in real time, such as the load-bearing capacity of housing racks, the cleanliness of cages, and the wind speed of ventilation equipment.

[0072] Based on the laboratory animal center's workflow, different roles (such as administrator, laboratory technician, and cleaner) are defined and assigned corresponding permissions. Based on the role division, each employee is assigned specific facility access rights, such as access to breeding racks, movement of breeding cages, and opening of access control doors.

[0073] Establish access rules: Set opening hours for different areas or facilities, such as limiting access to the breeding area at night. Develop employee behavior guidelines within specific facilities, such as cage handling methods and cleaning procedures. Record the specific location of breeding racks and cages within the laboratory animal center to facilitate tracking and location. Record the use of breeding racks and cages, including the type of animals, number of animals, and experimental projects.

[0074] For example, experimenter Zhang San is assigned the authority to access specific breeding racks and mobile breeding cages, but does not have the authority to access the management interface of the access control system.

[0075] The breeding area is closed from 8 PM to 6 AM, and no one is allowed to enter. Furthermore, cages must be transported using a dedicated cart, avoiding manual carrying. The second cage on the third level of cage rack B is currently used to house mice for drug toxicity testing.

[0076] 2. Access Control Subsystem Design and Implementation The facility management subsystem is connected to the access control subsystem via a network or dedicated line, enabling real-time data transmission and synchronization. Whenever permissions are changed in the facility management subsystem, access rules in the access control subsystem are automatically updated. If the access control subsystem detects an abnormality, such as an unauthorized intrusion or equipment failure, an alarm is immediately triggered and sent to the facility management subsystem. Based on the alarm, the facility management subsystem automatically triggers the appropriate emergency response process, such as notifying security personnel and locking down the relevant area.

[0077] Install access control devices, such as access card readers, fingerprint readers, or facial recognition cameras, at the entrances and exits of the laboratory animal center and key areas (such as breeding areas and experimental areas). Based on the permissions assigned in the facility management subsystem, set access rules for the access control devices, such as which employees can access which areas.

[0078] Record the time, person, and area of ​​each access control system opening for easy analysis and tracing. Monitor the status of access control equipment in real time, such as whether it is faulty or has been illegally entered.

[0079] For example, at 8:00 AM, experimenter Zhang San successfully enters the enclosure using an access card. The access control system records this visit. If the access control system detects an attempt to enter the enclosure using an invalid access card, it immediately triggers an alarm and sends the alarm information to the facility management subsystem. Upon receiving the alarm, the facility management subsystem automatically notifies security personnel to respond on-site.

[0080] Obviously, the above embodiments are merely examples for clarity of explanation and are not intended to limit the implementation methods. Those skilled in the art will readily appreciate that other variations or modifications based on the above descriptions are possible. It is not necessary and impossible to enumerate all implementation methods here. Obvious variations or modifications arising therefrom remain within the scope of protection of the present invention.

Claims

1. A remote monitoring and data management system for experimental animals, comprising a process management subsystem for ethical approval of experimental animals, a cage management subsystem for application and management of experimental animal cages, an order and feeding management subsystem for purchasing and feeding experimental animals, an environmental monitoring subsystem for environmental monitoring and alarming of experimental animals, a server for processing experimental animal data, and several user terminals for accessing and manipulating data, wherein the process management subsystem, cage management subsystem, order and feeding management subsystem, and environmental monitoring subsystem are all signal-connected to the server and user terminals, and characterized in that: The environmental monitoring subsystem includes a breeding rack, on which a number of breeding cages are detachably mounted, each of which is equipped with a data acquisition module. The data acquisition module includes an odor sensor for monitoring the odor of the breeding cage and a weight sensor for monitoring the weight inside the breeding cage; When the feeding cage is on the feeding rack and the experimental animal is in the feeding cage, the odor information in the feeding cage collected by the odor sensor is marked as the first odor information; when the server determines that the experimental animal has left the feeding cage based on the weight information monitored in real time by the weight sensor, the real-time odor information in the feeding cage collected by the odor sensor at this time is marked as the second odor information; when the experimental animal returns to the feeding cage, the odor information in the feeding cage collected by the odor sensor again is marked as the third odor information; when the feeding cage is placed back on the feeding rack, the odor information collected by the odor sensor is marked as the fourth odor information; When the server compares the first odor information with the fourth odor information, if the comparison result is less than a preset comparison threshold, it is determined that the breeding cage is returned to the breeding rack and the return position is correct; When the server compares the second odor information with a preset odor information threshold, if the second odor information is less than the odor information threshold, it is determined that the distance between the breeding cage and the experimental animal exceeds the preset range, and the server notifies the experimenter through the user terminal; When the server compares the third odor information with the second odor information, if the third odor information is the same as the second odor information and the weight information monitored in real time by the weight sensor remains unchanged, it is determined that the experimental animal is correctly matched with the breeding cage.

2. The experimental animal remote monitoring and data management system according to claim 1, characterized in that: The process management subsystem includes an automatic saving module for automatically saving application information for experimental animal ethics approval; a preliminary review module for performing routine error checks on application information; a review module for supporting review of individual entries; a modification trace module for recording modifications during the approval process and highlighting the modifications; and a review module for specifying review experts to review or setting a threshold to enable multiple experts to review.

3. The remote monitoring and data management system for experimental animals according to claim 2, characterized in that: The cage management subsystem includes an instant application module for applying for cage spaces immediately; a queuing reservation module for reserving cage spaces and queuing in order; a cage application module for applying for fixed cage spaces; an idle cage display module for publicly displaying the number of idle cages; a feeding application designation module for specifying cage spaces when applying for feeding; and a cage restriction module for limiting the number of cages according to research groups or units.

4. The remote monitoring and data management system for experimental animals according to claim 3, characterized in that: The order and breeding management subsystem includes a shopping cart module for users to operate in a shopping cart manner and purchase experimental animals; a cost calculation module for calculating and statistic transportation costs, packaging costs and management fees; and an order sending module for sending orders to suppliers with one click; The supplier feedback module is used to receive direct feedback from suppliers; the animal reception module is used to solve the problems of receiving experimental animals; and the self-breeding animal management module is used to support the sale, inventory display and transfer of self-breeding animals to external suppliers.

5. The experimental animal remote monitoring and data management system according to claim 4, characterized in that: The data acquisition module also includes a temperature sensor for monitoring the temperature in the breeding cage and a humidity sensor for monitoring the humidity in the breeding cage. Both the temperature sensor and the humidity sensor are connected to the server signal. The server issues an over-limit alarm based on the data collected by the temperature sensor and the humidity sensor, and pushes the alarm information through the user end.

6. The experimental animal remote monitoring and data management system according to claim 5, characterized in that: The data acquisition module also includes an RFID reader. An RFID tag is installed on the breeding cage. The RFID reader is used to read the information of the RFID tag on the breeding cage. The information of the RFID tag is used to track and identify the breeding cage and the experimental animals therein.

7. The remote monitoring and data management system for experimental animals according to claim 6, characterized in that: The environmental monitoring subsystem also includes a docking module, which is used to dock with the independent ventilation cage host and read the temperature, humidity, pressure difference and air supply data, issue an over-limit alarm, and push the alarm information through the user end.

8. The experimental animal remote monitoring and data management system according to claim 7, characterized in that: The server includes a data analysis module, which is used to analyze the experimental animal data uploaded by the user and generate an analysis report on the health status of the experimental animals and the breeding environment.

9. The experimental animal remote monitoring and data management system according to claim 8, characterized in that: The user end includes PC, mobile and large-screen display ends, and is used to support multi-platform access and data operation.

10. The remote monitoring and data management system for experimental animals according to claim 9, characterized in that: It also includes a facility management subsystem, which is used to manage the experimental animal center's infrastructure, facility permissions, entry and exit rules, breeding racks and cages. The facility management subsystem signal is connected to the access control subsystem, which is used for security management of the experimental animal center.

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