Multi-path automatic pipetting system and method for automatic chemical synthesis experiment

Abstract

The invention discloses a multi-path automatic pipetting system for an automatic chemical synthesis experiment. The multi-path automatic pipetting system comprises a mechanical movement mechanism, a multi-path pipetting mechanism, a locking structure and a control system, the mechanical movement mechanism comprises X-axis and Y-axis mechanical arms which are vertically arranged, is driven by a stepping servo push rod motor, and is matched with an X / Y-axis photoelectric switch to calibrate displacement so as to construct a planar movement coordinate system; the multi-path pipetting mechanism is provided with a plurality of pipetting heads, and each channel is connected with a peristaltic pump through a connecting pipeline and is provided with a flow switch for monitoring the liquid flow in real time. The locking structure comprises a pipette fixing head, an inverted trapezoidal pressing ring and a pipette locking head, and the pipette penetrates through the pipette fixing head, the inverted trapezoidal pressing ring and the pipette locking head and is screwed into the pressing ring through threads to realize sealing; the control system is connected with the stepping motor, the peristaltic pump and the flow switch, calculates a movement track and pump parameters after receiving an instruction, synchronously controls the pipetting operation and processes a flow signal; according to the system, multi-channel accurate positioning, stable flow control and leakage prevention are achieved, and the matching precision, safety and automation efficiency of chemical synthesis experiments are remarkably improved.

Description

Technical Field

[0001] The present invention relates to the technical field of chemical experimental equipment, in particular to a multi-channel automatic liquid transfer system and method for automatic chemical synthesis experiments. Background Art

[0002] In the field of chemical synthesis experiments, pipetting is one of the most basic and frequent operations, and its accuracy and efficiency directly affect the reliability and throughput of experimental results. For a long time, this operation has mainly relied on experimenters to manually use pipettes. Manual operation is not only time-consuming and labor-intensive, but also difficult to sustain. More importantly, it is prone to introducing subjective errors. This is especially true when performing multi-step continuous syntheses or handling trace or toxic reagents. The repeatability and safety of the operation face severe challenges. As synthetic chemistry develops towards high-throughput and automation, this traditional method that relies on manpower has gradually become a bottleneck for improving efficiency and precise process control.

[0003] Although some automated pipetting devices have appeared on the market in an attempt to replace manual operations, these existing technologies still have obvious deficiencies in practical applications. For example, when pipetting operations need to be performed on multiple different positions at the same time, existing systems often find it difficult to achieve precise coordinated control of multi-channel pipetting, resulting in inconsistent pipetting volumes or inaccurate positioning in each channel. In addition, during the pipetting process, the liquid delivery stability is poor, and flow fluctuations or even loss of control are prone to occur, affecting the reliability of pipetting accuracy. There are also hidden dangers in the sealing and fixation of the liquid transmission link, which may cause liquid leakage, which not only pollutes the environment, but also brings safety hazards. It is difficult to meet the strict requirements of complex chemical synthesis experiments for precise proportions of multiple reagents, fast and stable pipetting, and safe operation.

[0004] Therefore, there is an urgent need to develop a novel automated pipetting system and method that can effectively overcome the aforementioned difficulties. Specifically, a solution is needed that can achieve high-precision multi-channel parallel pipetting control, ensure stable and reliable liquid delivery throughout the entire process, have an effective leak prevention mechanism, and be easily integrated into automated synthesis experimental processes to truly meet the comprehensive requirements of modern chemical synthesis experiments for automation, high throughput, high precision, and safety. Summary of the Invention

[0005] In response to the above technical problems in the related art, the present invention proposes a multi-channel automatic pipetting system and method for automated chemical synthesis experiments, which can overcome the above-mentioned shortcomings of the prior art.

[0006] To achieve the above technical objectives, the technical solution of the present invention is implemented as follows: According to a first aspect of the present invention, there is provided a multi-channel automatic pipetting system for automated chemical synthesis experiments; The multi-channel automatic pipetting system for automatic chemical synthesis experiments includes a mechanical motion mechanism, a multi-channel pipetting mechanism, a locking structure and a control system; the mechanical motion mechanism includes an X-axis mechanical arm and a Y-axis mechanical arm arranged perpendicular to each other, which form a planar motion coordinate system; the X-axis mechanical arm and the Y-axis mechanical arm are both driven by stepping servo push rod motors and are respectively equipped with an X-axis photoelectric switch and a Y-axis photoelectric switch for displacement calibration; the multi-channel pipetting mechanism includes at least two pipetting heads, each of which independently forms a pipetting channel; each pipetting channel is connected by The pipeline is connected to the peristaltic pump and a flow switch is provided on each pipetting channel for real-time monitoring of liquid flow; the locking structure includes a pipetting fixed head, a pressure ring and a pipetting locking head; the pipette is sequentially passed through the U-shaped hole of the pipetting fixed head, the pressure ring and the pipette locking head, and the pressure ring adopts an inverted trapezoidal design, which tightens the pipette when screwed into the pipetting locking head through a thread; the control system is respectively connected to the stepping servo push rod motor, the peristaltic pump and the flow switch, and is used to receive pipetting instructions, calculate motion trajectory and pump parameters, control pipetting operations and process flow feedback signals.

[0007] Furthermore, it also includes an intelligent liquid level detection unit and a waste liquid recovery unit; the intelligent liquid level detection unit is a non-contact liquid level sensor arranged on the side wall of the reaction solvent barrel for real-time detection of the liquid level and alarm; the waste liquid recovery unit includes a waste liquid collection box arranged below the pipetting head and a waste liquid recovery barrel connected to the waste liquid pipeline, and the waste liquid pipeline is controlled by the control system to transport the waste liquid.

[0008] Furthermore, the X-axis robotic arm and the Y-axis robotic arm adopt a high-precision linear guide rail and slider structure; the peristaltic pump controls the liquid delivery flow by adjusting the rotation speed.

[0009] Furthermore, when the flow switch detects abnormal flow, the control system automatically adjusts the rotation speed of the peristaltic pump or stops the pipetting operation.

[0010] Furthermore, the inverted trapezoidal cone surface of the pressure ring and the internal thread of the pipette locking head form a linear extrusion structure, and the pipette is fixed by a radial locking force; the non-contact liquid level sensor adopts a flexible capacitive liquid level detection method, and the data of the non-contact liquid level sensor is transmitted to the control system in real time, and an audible and visual alarm is triggered when the liquid level is lower than the threshold.

[0011] Furthermore, the waste liquid recovery barrel is arranged on the side of the reaction solvent barrel, and the waste liquid pipeline transportation path is controlled by the control system instructions.

[0012] Furthermore, the step servo push rod motor is connected to the X-axis robotic arm and the Y-axis robotic arm through a transmission mechanism, and the displacement accuracy is calibrated in real time by the X-axis photoelectric switch and the Y-axis photoelectric switch. According to a second aspect of the present invention, a multi-channel automatic pipetting method for automated chemical synthesis experiments is provided; The multi-channel automatic pipetting method for automated chemical synthesis experiments includes the following steps: Step S1: placing the reagent container and the reaction container at designated locations on the laboratory table; Step S2: inputting pipetting parameters through the control system; Step S3: The control system calculates the motion trajectory and controls the robotic arm to move the pipetting head to above the reagent container; Step S4: starting the peristaltic pump to draw the reagent, and the flow switch monitors the flow in real time; Step S5: After the pipetting volume reaches the standard, the peristaltic pump is stopped, and the pipetting head is moved to the top of the reaction container to inject the reagent; Step S6: Repeat steps S3-S5 to complete the multi-channel pipetting operation; Step S7: After the pipetting is completed, the control system drives the peristaltic pump in reverse to recover the residual reagent in the pipetting head to the reagent container.

[0013] Furthermore, when the peristaltic pump draws the reagent, a non-contact liquid level sensor is simultaneously started to monitor the liquid level height of the reaction solvent barrel.

[0014] Furthermore, when the flow switch detects a flow deviation exceeding ±5%, the control system dynamically corrects the peristaltic pump speed; if the deviation persists for 2 seconds, pipetting is terminated.

[0015] The beneficial effects of the present invention are as follows: through the precise control of the mechanical motion mechanism and the coordinated design of the multi-channel pipetting mechanism, the multi-channel pipetting positioning is accurate and the flow rate is stable and reliable, which effectively solves the problems of imprecise multi-channel pipetting control and liquid leakage; combined with intelligent liquid level monitoring and automated recovery mechanism, the comprehensive goal of improving the ratio accuracy, operational safety and automation efficiency of chemical synthesis experiments is achieved. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0017] Figure 1 This is a schematic diagram of the overall structure of a multi-channel automatic pipetting system for automated chemical synthesis experiments according to an embodiment of the present invention; Figure 2 1 is a schematic structural diagram of several pipetting heads and a waste liquid collection box of a multi-channel automatic pipetting system for automated chemical synthesis experiments according to an embodiment of the present invention; Figure 3This is a partial structural diagram of a multi-channel automatic pipetting system for automated chemical synthesis experiments according to an embodiment of the present invention; Figure 4 2 is a schematic structural diagram of a single pipetting head of a multi-channel automatic pipetting system for automated chemical synthesis experiments according to an embodiment of the present invention; Figure 5 This is an exploded view of a single pipetting head of a multi-channel automatic pipetting system for automated chemical synthesis experiments according to an embodiment of the present invention; Figure 6 This is a schematic diagram of the X-axis photoelectric switch arrangement position of a multi-channel automatic pipetting system for automated chemical synthesis experiments according to an embodiment of the present invention; Figure 7 This is a schematic diagram of the Y-axis photoelectric switch arrangement position of a multi-channel automatic pipetting system for automated chemical synthesis experiments according to an embodiment of the present invention; Figure 8 This is a schematic diagram of the location of a non-contact liquid level sensor on a reaction solvent barrel of a multi-channel automatic pipetting system for automated chemical synthesis experiments according to an embodiment of the present invention; Figure 9 This is a liquid inlet principle diagram of a multi-channel automatic pipetting system for automated chemical synthesis experiments according to an embodiment of the present invention; Figure 10 2. It is a schematic diagram of the liquid discharge principle of a multi-channel automatic pipetting system for automated chemical synthesis experiments according to an embodiment of the present invention; In the figure: 1. X-axis robotic arm; 2. Y-axis robotic arm; 3. Pipette head; 4. Waste liquid collection box; 5. Peristaltic pump; 6. Reaction solvent barrel; 7. Liquid level detection switch; 8. Waste liquid recovery barrel; 9. Control system; 10. Pipette fixed head; 11. Pressing ring; 12. Pipette locking head; 13. X-axis photoelectric switch; 14. Y-axis photoelectric switch; 15. Non-contact liquid level sensor; 16. Flow switch; 17. Reaction vessel; 18. Reagent container. DETAILED DESCRIPTION

[0018] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. All other embodiments obtained by ordinary technicians in this field based on the embodiments of the present invention are within the scope of protection of the present invention.

[0019] It should be understood that in the description of the embodiments of the present invention, the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the embodiments of the present invention and simplifying the description, rather than indicating or implying that the devices or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the embodiments of the present invention. In addition, the terms "first" and "second" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the said features. In the description of the embodiments of the present invention, the meaning of "several" is two or more, unless otherwise clearly and specifically defined.

[0020] like Figure 1-10 As shown, a multi-channel automatic pipetting system for automatic chemical synthesis experiments according to an embodiment of the present invention includes a mechanical motion mechanism, a multi-channel pipetting mechanism, a locking structure and a control system 9; the mechanical motion mechanism includes an X-axis robot arm 1 and a Y-axis robot arm 2 arranged perpendicular to each other, and the two constitute a planar motion coordinate system; the X-axis robot arm 1 and the Y-axis robot arm 2 are both driven by stepping servo push rod motors and are respectively equipped with an X-axis photoelectric switch 13 and a Y-axis photoelectric switch 14 for displacement calibration; the multi-channel pipetting mechanism includes at least two pipetting heads 3, each pipetting head 3 independently forming a pipetting channel; each pipetting channel is connected to a plurality of pipetting heads 3, wherein the plurality of pipetting heads 3 are connected to the ... channels are connected to the plurality of pipetting channels 9; The connecting pipe is connected to the peristaltic pump 5 and a flow switch 16 is provided on each pipetting channel for real-time monitoring of the liquid flow; the locking structure includes a pipetting fixed head 10, a pressure ring 11 and a pipetting locking head 12; the pipette is sequentially passed through the U-shaped hole of the pipetting fixed head 10, the pressure ring 11 and the pipetting locking head 12, and the pressure ring 11 adopts an inverted trapezoidal design, which tightens the pipette when screwed into the pipetting locking head 12 by a thread; the control system 9 is respectively connected to the stepping servo push rod motor, the peristaltic pump 5 and the flow switch 16, and is used to receive pipetting instructions, calculate motion trajectory and pump parameters, control pipetting operations and process flow feedback signals.

[0021] According to an embodiment of the present invention, a multi-channel automatic pipetting system for automated chemical synthesis experiments, in a specific embodiment, further includes an intelligent liquid level detection unit and a waste liquid recovery unit; the intelligent liquid level detection unit is a non-contact liquid level sensor 15 arranged on the side wall of the reaction solvent barrel 6 for real-time detection of the liquid level and alarm; the waste liquid recovery unit includes a waste liquid collection box 4 arranged below the pipetting head 3 and a waste liquid recovery barrel 8 connected to a waste liquid pipeline, and the waste liquid pipeline is controlled by a control system 9 to transport waste liquid.

[0022] According to an embodiment of the present invention, a multi-channel automatic pipetting system for automated chemical synthesis experiments, in a specific embodiment, the X-axis robotic arm 1 and the Y-axis robotic arm 2 adopt a high-precision linear guide and slider structure; the peristaltic pump 5 controls the liquid delivery flow by adjusting the rotation speed.

[0023] According to an embodiment of the present invention, a multi-channel automatic pipetting system for automatic chemical synthesis experiments, in a specific embodiment, when the flow switch 16 detects abnormal flow, the control system 9 automatically adjusts the speed of the peristaltic pump 5 or stops the pipetting operation.

[0024] According to an embodiment of the present invention, a multi-channel automatic pipetting system for automated chemical synthesis experiments is described. In a specific embodiment, the inverted trapezoidal cone surface of the pressure ring 11 and the internal thread of the pipette locking head 12 form a linear extrusion structure, and the pipette is fixed by a radial locking force; the non-contact liquid level sensor 15 adopts a flexible capacitive liquid level detection method, and the data of the non-contact liquid level sensor 15 is transmitted to the control system 9 in real time, and an audible and visual alarm is triggered when the liquid level is lower than the threshold.

[0025] According to an embodiment of the present invention, a multi-channel automatic pipetting system for automated chemical synthesis experiments, in a specific embodiment, the waste liquid recovery barrel 8 is arranged on the side of the reaction solvent barrel 6, and the waste liquid pipeline transportation path is controlled by the control system 9 instructions.

[0026] According to an embodiment of the present invention, a multi-channel automatic pipetting system for automated chemical synthesis experiments, in a specific embodiment, the stepping servo push rod motor is connected to the X-axis robotic arm 1 and the Y-axis robotic arm 2 through a transmission mechanism, and the displacement accuracy is calibrated in real time by the X-axis photoelectric switch 13 and the Y-axis photoelectric switch 14.

[0027] On the other hand, a multi-channel automatic pipetting method for automated chemical synthesis experiments according to an embodiment of the present invention specifically comprises the following steps: Step S1: placing the reagent container 18 and the reaction container 17 at designated locations on the laboratory table; Step S2: inputting pipetting parameters through the control system 9; Step S3: the control system 9 calculates the motion trajectory and controls the robotic arm to move the pipetting head 3 to above the reagent container 18; Step S4: starting the peristaltic pump 5 to draw the reagent, and the flow switch 16 monitors the flow in real time; Step S5: After the pipetting volume reaches the standard, the peristaltic pump 5 is stopped, and the pipetting head 3 is moved to the top of the reaction container 17 to inject the reagent; Step S6: Repeat steps S3-S5 to complete the multi-channel pipetting operation; Step S7 : After the pipetting is completed, the control system 9 drives the peristaltic pump 5 in reverse to recover the residual reagent in the pipetting head 3 to the reagent container 18 .

[0028] According to a multi-channel automatic pipetting method for automated chemical synthesis experiments described in an embodiment of the present invention, in a specific embodiment, when the peristaltic pump 5 draws reagents, the non-contact liquid level sensor 15 is synchronously started to monitor the liquid level of the reaction solvent barrel 6.

[0029] According to an embodiment of the present invention, a multi-channel automatic pipetting method for automated chemical synthesis experiments, in a specific embodiment, when the flow switch 16 detects that the flow deviation exceeds ±5%, the control system 9 dynamically corrects the speed of the peristaltic pump 5; if the deviation lasts for 2 seconds, the pipetting is terminated.

[0030] In order to facilitate understanding of the above technical solutions of the present invention, the above technical solutions of the present invention are described in detail below through specific usage methods.

[0031] More specifically, a multi-channel automatic pipetting system for automated chemical synthesis experiments according to the present invention comprises: 1. Mechanical motion mechanism: It consists of an X-axis robot arm 1 and a Y-axis robot arm 2. The X-axis robot arm 1 and the Y-axis robot arm 2 are arranged perpendicular to each other to form a planar motion coordinate system. Both the X-axis robot arm 1 and the Y-axis robot arm 2 use high-precision linear guide rails and slider structures to ensure the smoothness and accuracy of movement. The X-axis robot arm and the Y-axis robot arm 2 are respectively driven by stepper servo push rod motors. The stepper servo push rod motors are connected to the X-axis robot arm and the Y-axis robot arm 2 through a transmission mechanism. They can accurately control the movement distance and speed of the X-axis robot arm and the Y-axis robot arm 2 in the X-axis and Y-axis directions. The X-axis robot arm and the Y-axis robot arm 2 are respectively equipped with high-precision X-axis photoelectric switches 13 and Y-axis photoelectric switches 14 for calibration, thereby achieving precise positioning of the pipette head 3 above the laboratory table.

[0032] 2. Multi-channel pipetting mechanism: It includes several pipetting heads 3, each of which corresponds to one pipetting channel. The pipetting head 3 is connected to the peristaltic pump 5 through a connecting pipe. The peristaltic pump 5 serves as the power source for liquid delivery. It can accurately control the liquid delivery flow rate by adjusting the pump speed, thereby achieving accurate pipetting of different volumes of liquid. Each pipetting channel is provided with a flow switch 16, which is used to monitor the flow state and flow rate of the liquid in real time and feed back the monitoring signal to the control system 9. When the liquid flow is abnormal, the control system 9 can respond in time, adjust the speed of the peristaltic pump 5 or stop the pipetting operation to ensure the accuracy and safety of the pipetting.

[0033] 3. Locking structure: The pipette is inserted into the U-shaped hole in the middle of the pipette fixed head 10 of the pipette head 3. After the pipette passes through the pressure ring 11 of the liquid head 3 and the pipette locking head 12, since the pressure ring 11 adopts an inverted trapezoidal design, when it is screwed into the pipette locking head 12, the pressure ring 11 cooperates with the thread to effectively lock the pipette, ensuring the reliability and stability of the liquid during the pipetting process, and avoiding liquid leakage that affects the experimental results or causes safety hazards.

[0034] 4. Control System: The control system 9 is connected to the stepper servo actuator motors of the X-axis robotic arm 1 and the Y-axis robotic arm 2, the peristaltic pump 5, and the flow switch 16. The control system 9 receives user-inputted pipetting commands, calculates the motion trajectory of the X-axis robotic arm 1 and / or the Y-axis robotic arm 2 and the operating parameters of the peristaltic pump 5 based on the commands, and controls the motion of the X-axis robotic arm 1 and / or the Y-axis robotic arm 2, as well as the start and stop and speed of the peristaltic pump 5, to achieve precise control of multi-channel automated pipetting. Furthermore, the control system 9 processes and analyzes signals fed back by the flow switch, monitoring the pipetting process in real time and ensuring smooth operation.

[0035] 5. Intelligent liquid level detection: A non-contact liquid level sensor 15 is provided on the side wall of the reaction solvent barrel 6. The non-contact liquid level sensor 15 is used to implement an integrated flexible non-contact capacitive liquid level detection method, which can provide real-time feedback on the liquid level positioning accuracy of the reaction solvent barrel 6 and can issue an alarm in the event of abnormal liquid level conditions.

[0036] 6. Waste liquid recovery: A waste liquid collection box for collecting waste liquid is provided under the pipetting head 3; a waste liquid recovery barrel 8 connected to a waste liquid pipeline is provided on the side of the reaction solvent barrel 6. The waste liquid pipeline is used to transport waste liquid and discharge it into the waste liquid recovery barrel 8 under the instruction of the control system 9.

[0037] In specific use, the method for automatic multi-channel automatic pipetting of a multi-channel automatic pipetting system for automatic chemical synthesis experiments according to the present invention specifically includes the following steps: 1. When using the multi-channel automatic pipette for automatic chemical synthesis experiments of the present invention to perform chemical synthesis reaction experiments, first, the reagents to be used are placed in the reagent containers 18 and placed in designated positions on the experimental table, and the reaction container 17 is also placed in the corresponding position.

[0038] 2. The user inputs a pipetting instruction through the operation interface of the control system 9. The pipetting instruction includes information such as the type of reagent to be pipetted, the pipetting volume, and the pipetting target container.

[0039] 3. After receiving the pipetting instruction, the control system 9 calculates the motion trajectory of the X-axis robot 1 and the Y-axis robot 2 and the operating parameters of the stepper servo push rod motor according to the preset algorithm, and controls the X-axis robot 1 and the Y-axis robot 2 to move the pipetting head 3 to the top of the specified reagent container 18.

[0040] 4. When the pipetting head 3 reaches the designated position, the control system 9 activates the corresponding peristaltic pump 5 and adjusts its speed according to the set pipetting volume. The peristaltic pump 5 uses its squeezing action to draw the reagent from the reagent container 18 into the connecting pipe and deliver it to the pipetting head 3. During the liquid delivery process, the flow switch 16 monitors the liquid flow rate in real time and feeds the monitoring signal back to the control system 9.

[0041] 5. When the volume of the transferred liquid reaches the set value, the control system 9 controls the peristaltic pump 5 to stop working, and then controls the X-axis robot 1 and the Y-axis robot 2 to move the pipetting head 3 to above the reaction container 17, and starts the peristaltic pump 5 again to accurately inject the reagent into the reaction container 17.

[0042] 6. Repeat the above steps to complete the pipetting operations of multiple liquids in sequence, and realize the precise ratio and automatic pipetting of multiple reagents in chemical synthesis reaction experiments.

[0043] 7. After the pipetting operation is completed, the liquid recovery process will be started. The control system 9 will control the peristaltic pump 5 to adjust the flow direction and discharge the remaining reagent in the pipetting head 3 into the reagent container 18 in the opposite direction to complete the reagent recovery.

[0044] In summary, with the help of the above-mentioned technical solution of the present invention, through the precise control of the mechanical motion mechanism and the coordinated design of the multi-channel pipetting mechanism, the multi-channel pipetting positioning is accurate and the flow rate is stable and reliable, which effectively solves the problems of inaccurate multi-channel pipetting control and liquid leakage; combined with intelligent liquid level monitoring and automatic recovery mechanism, the comprehensive goal of improving the ratio accuracy, operational safety and automation efficiency of chemical synthesis experiments is achieved.

[0045] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A multi-channel automatic pipetting system for automated chemical synthesis experiments, characterized in that: The invention comprises a mechanical motion mechanism, a multi-channel pipetting mechanism, a locking structure and a control system (9); the mechanical motion mechanism comprises an X-axis mechanical arm (1) and a Y-axis mechanical arm (2) which are arranged perpendicular to each other, and the two constitute a plane motion coordinate system; the X-axis mechanical arm (1) and the Y-axis mechanical arm (2) are driven by stepping servo push rod motors, and are respectively equipped with an X-axis photoelectric switch (13) and a Y-axis photoelectric switch (14) for displacement calibration; the multi-channel pipetting mechanism comprises at least two pipetting heads (3), each pipetting head (3) independently constituting a pipetting channel; each pipetting channel is connected to a peristaltic pump (5) through a connecting pipe, and each pipetting channel has a plurality of pipetting heads (13) and a plurality of pipetting heads (14) on each pipetting channel. A flow switch (16) is provided for real-time monitoring of liquid flow; the locking structure comprises a pipette fixed head (10), a pressure ring (11) and a pipette locking head (12); the pipette is sequentially passed through the U-shaped hole of the pipette fixed head (10), the pressure ring (11) and the pipette locking head (12); the pressure ring (11) adopts an inverted trapezoidal design and presses the pipette when screwed into the pipette locking head (12); the control system (9) is respectively connected to the stepping servo push rod motor, the peristaltic pump (5) and the flow switch (16), and is used to receive pipetting instructions, calculate motion trajectory and pump parameters, control pipetting operations and process flow feedback signals.

2. A multi-channel automatic pipetting system for automated chemical synthesis experiments according to claim 1, characterized in that: It also includes an intelligent liquid level detection unit and a waste liquid recovery unit; the intelligent liquid level detection unit is a non-contact liquid level sensor (15) arranged on the side wall of the reaction solvent barrel (6) for real-time detection of the liquid level and alarm; the waste liquid recovery unit includes a waste liquid collection box (4) arranged below the pipetting head (3) and a waste liquid recovery barrel (8) connected to a waste liquid pipeline, and the waste liquid pipeline is controlled by a control system (9) to transport waste liquid.

3. A multi-channel automatic pipetting system for automatic chemical synthesis experiments according to claim 1, characterized in that: The X-axis robotic arm (1) and the Y-axis robotic arm (2) adopt a high-precision linear guide rail and a slider structure; the peristaltic pump (5) controls the liquid delivery flow rate by adjusting the rotation speed.

4. A multi-channel automatic pipetting system for automated chemical synthesis experiments according to claim 1, characterized in that: The control system (9) automatically adjusts the rotation speed of the peristaltic pump (5) or stops the pipetting operation when the flow switch (16) detects abnormal flow.

5. A multi-channel automatic pipetting system for automatic chemical synthesis experiments according to claim 2, characterized in that: The inverted trapezoidal conical surface of the pressure ring (11) and the internal thread of the pipette locking head (12) form a linear extrusion structure, and the pipette is fixed by a radial locking force; the non-contact liquid level sensor (15) adopts a flexible capacitive liquid level detection method, and the data of the non-contact liquid level sensor (15) is transmitted to the control system (9) in real time, and an audible and visual alarm is triggered when the liquid level is lower than a threshold.

6. A multi-channel automatic pipetting system for automated chemical synthesis experiments according to claim 2, characterized in that: The waste liquid recovery barrel (8) is arranged on the side of the reaction solvent barrel (6), and the waste liquid pipeline transportation path is controlled by the control system (9) instructions.

7. A multi-channel automatic pipetting system for automated chemical synthesis experiments according to claim 1, characterized in that: The step servo push rod motor is connected to the X-axis mechanical arm (1) and the Y-axis mechanical arm (2) through a transmission mechanism, and the displacement accuracy is calibrated in real time by the X-axis photoelectric switch (13) and the Y-axis photoelectric switch (14).

8. A multi-channel automatic pipetting method for automated chemical synthesis experiments, implemented based on a multi-channel automatic pipetting system for automated chemical synthesis experiments according to any one of claims 2 to 7, characterized in that: The following steps are involved: S1: Place the reagent container (18) and the reaction container (17) at the designated location on the laboratory table; S2: Input pipetting parameters through the control system (9); S3: The control system (9) calculates the motion trajectory and controls the robotic arm to move the pipetting head (3) to above the reagent container (18); S4: Start the peristaltic pump (5) to draw the reagent, and the flow switch (16) monitors the flow in real time; S5: After the pipetting volume reaches the standard, the peristaltic pump (5) is stopped, and the pipetting head (3) is moved to the top of the reaction container (17) to inject the reagent; S6: Repeat steps S3-S5 to complete the multi-channel pipetting operation; S7: After the pipetting is completed, the control system (9) drives the peristaltic pump (5) in reverse to recover the residual reagent in the pipetting head (3) to the reagent container (18).

9. A multi-channel automatic pipetting method for automated chemical synthesis experiments according to claim 8, characterized in that: When the peristaltic pump (5) draws the reagent, the non-contact liquid level sensor (15) is simultaneously started to monitor the liquid level height of the reaction solvent barrel (6).

10. A multi-channel automatic pipetting method for automated chemical synthesis experiments according to claim 8, characterized in that: When the flow switch (16) detects that the flow deviation exceeds ±5%, the control system (9) dynamically corrects the speed of the peristaltic pump (5); if the deviation lasts for 2 seconds, the pipetting is terminated.

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