Solid preparation for reducing uric acid as well as preparation method and application of solid preparation

Abstract

The invention relates to a solid preparation for reducing uric acid. The solid preparation is prepared from the following raw materials in parts by weight: 0.125 to 0.225 part of maca extract powder, 0.05 to 0.15 part of sweet orange extract powder, 0.015 to 0.035 part of fish collagen and 0.08 to 0.16 part of pomegranate powder. The solid preparation for reducing uric acid can inhibit the activity of xanthine oxidase, the inhibition rate is 89%, and the effect of reducing uric acid is achieved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of uric acid-lowering preparations, in particular to the application of a uric acid-lowering solid preparation. BACKGROUND

[0002] Current uric acid-lowering drugs are mainly divided into two categories, namely drugs that inhibit uric acid production and drugs that promote uric acid excretion. However, existing uric acid-lowering drugs have limitations in terms of bioavailability, drug stability and side effect control. In particular, during long-term use, some drugs can cause gastrointestinal discomfort, liver and kidney function damage and other adverse reactions.

[0003] Currently, single inhibition of uric acid synthesis or single promotion of uric acid excretion is usually used to lower uric acid on the market, and the therapeutic effect is mediocre, and it is only a palliative treatment. According to the cause of high uric acid, when lowering uric acid, the problem of excessive production and insufficient excretion of uric acid needs to be solved, and both pipes are connected, and the target is hit, so as to quickly and effectively lower uric acid. SUMMARY

[0004] In view of the above prior art, the present application provides a solid preparation for lowering uric acid. The whole fruit and vegetable food can not only inhibit the production of uric acid, but also promote the excretion of uric acid, and is efficient, safe and has no side effects.

[0005] In a first aspect of the present application, the present application provides a solid preparation for lowering uric acid, which is composed of the following raw materials by weight: maca extract powder 0.125-0.225 parts, sweet orange extract powder 0.05-0.15 parts, fish collagen 0.015-0.035 parts, and pomegranate powder 0.08-0.16 parts.

[0006] By adopting the above technical scheme, the present application provides a solid preparation for lowering uric acid. Vitamin C in sweet orange extract powder can competitively inhibit the reabsorption of uric acid by renal tubules, promote the excretion of uric acid from urine, and flavonoids such as hesperidin have strong anti-inflammatory and antioxidant effects, which can alleviate the oxidative stress and inflammatory response caused by hyperuricemia; Maca extract powder may mainly act on the whole body to improve metabolism and anti-inflammatory, and the two intervene from two different aspects of "excretion" and "metabolism", realize the inhibition of xanthine oxidase activity, the inhibition rate is 89%, achieve the effect of lowering uric acid, and then can alleviate and improve a series of disease symptoms such as gout caused by high uric acid. Prevent the occurrence of chronic diseases such as cardiovascular disease and diabetes induced by high uric acid.

[0007] Optionally, the mass ratio of the maca extract powder and the sweet orange extract powder is (0.83-4.5):1.

[0008] By adopting the technical scheme, the quality ratio of the maca extract powder and the sweet orange extract powder is controlled, and when the quality ratio of the maca extract powder and the sweet orange extract powder is (0.83-4.5):1, the solid preparation for reducing uric acid can achieve a good effect of reducing uric acid.

[0009] Optionally, the preparation method of the maca extract powder comprises the following steps: a1: pretreatment: removing leaves and root hairs of fresh maca, washing, and slicing; a2: grinding: grinding the sliced maca to obtain maca powder; a3: taking a composite enzyme, preparing a composite enzyme aqueous solution, adding the maca powder, and enzymolysis to obtain an enzymolysis raw material; a4: separation: centrifugation, removal of precipitate, collection of the enzymolysis solution, and homogenization; a5: drying: concentrating and drying the homogenized enzymolysis solution to obtain the maca extract powder.

[0010] Optionally, in step a3, the composite enzyme is composed of pectinase and acid protease, and the mass ratio of the pectinase to the acid protease is 1:(1-1.2).

[0011] By adopting the technical scheme, the pectinase can destroy the cell wall and intercellular layer, so that the acid protease can enter the inside and destroy the protein network, and finally the active ingredients in the maca are efficiently and comprehensively released, and the maca extract powder contains more active ingredients, which is more conducive to achieving the effect of reducing uric acid.

[0012] Optionally, in step a3, the mass of the composite enzyme is 0.8% of the mass of the maca powder, the enzymolysis temperature is controlled at 45-55 DEG C, the pH is controlled at 3-4, and the enzymolysis time is 2-3 hours.

[0013] Optionally, in step a5, the drying is spray drying.

[0014] Optionally, the preparation method of the sweet orange extract powder comprises the following steps: b1: grinding the dried sweet orange peel with a grinder to obtain sweet orange peel dry powder; b2: using an edible ethanol solution with a concentration of 60-70 (V / V)% as an extraction solvent, the use amount ratio of the sweet orange peel powder to the extraction solvent is 1g:(10-15)mL, reflux extraction is performed 2-4 times, each time for 2-3 hours, and the extraction solutions are combined; b3: concentrating the combined extraction solutions to obtain concentrated extract; b4: drying the concentrated extract to obtain the sweet orange extract powder.

[0015] Optionally, the one solid preparation for reducing uric acid further comprises the following raw materials in parts by weight: strawberry powder 0.005-0.015 parts, cherry powder 0.05-0.15 parts, inulin 0.05-0.15 parts, mixed vegetable powder 0.002-0.004 parts, carrot powder 0.02-0.04 parts, orange powder essence 0.005-0.015 parts, potassium citrate 0.01-0.03 parts, polydextrose 0.16-0.28 parts, lactose 0.065-0.105 parts, sucralose 0.001-0.003 parts.

[0016] By adopting the technical scheme, the formula of the whole fruit and vegetable food can achieve the effect of reducing uric acid, reject the secondary damage of the medicine to the human body, and also soften blood vessels and improve blood vessel elasticity.

[0017] In the second aspect of the present application, a preparation method of the solid preparation for reducing uric acid in the first aspect of the present application is provided, comprising the following steps: S1: according to the weight ratio of each component, the maca extract powder, sweet orange extract powder, fish collagen, strawberry powder, polydextrose, pomegranate powder, cherry powder, inulin, lactose, mixed vegetable powder, sweet orange powder essence, potassium citrate, carrot powder, sucralose are weighed and mixed uniformly; S2: sealed packaging.

[0018] In the third aspect of the present application, the solid preparation for reducing uric acid in the first aspect of the present application is applied to the preparation of a medicine for preventing and / or treating hyperuricemia.

[0019] Optionally, the mass ratio of the maca extract powder and the sweet orange extract powder is (0.83-4.5):1.

[0020] In summary, the present application has at least one of the following beneficial technical effects: 1. The present application provides a solid preparation for reducing uric acid, vitamin C in the sweet orange extract powder can inhibit the reabsorption of uric acid in the renal tubule by competition, promote the excretion of uric acid from urine, flavonoids such as hesperidin have strong anti-inflammatory and antioxidant effects, and can relieve oxidative stress and inflammatory response caused by hyperuricemia; the maca extract powder may mainly act on the whole body to improve metabolism and anti-inflammatory, both of which intervene from two different aspects of "excretion" and "metabolism", realize the inhibition of xanthine oxidase activity, the inhibition rate is 89%, achieve the effect of reducing uric acid, and then can relieve and improve a series of disease symptoms such as gout caused by hyperuricemia; prevent the occurrence of chronic diseases such as cardiovascular disease and diabetes induced by hyperuricemia.

[0021] 2.The application provides a solid preparation for reducing uric acid, and the formula of the whole fruit and vegetable food can achieve the efficacy of uric acid-lowering drugs, reject the secondary damage of the drugs to the human body, and also soften blood vessels and improve blood vessel elasticity. Due to the superfine powder type, the preparation can be more finely absorbed and have a faster effect.

[0022] 3.The application provides an application of the solid preparation for reducing uric acid in the preparation of a medicine for preventing and / or treating hyperuricemia. DETAILED DESCRIPTION

[0023] The embodiments of the application will be described in detail below with reference to examples, but those skilled in the art will understand that the following examples are only used to illustrate the application and should not be regarded as limiting the scope of the application. The specific conditions not mentioned in the examples are carried out according to the conventional conditions or the conditions recommended by the manufacturer. The reagents or instruments not mentioned by the manufacturer are conventional products that can be purchased on the market.

[0024] Pectinase is purchased from Jiangsu Yuanzhiyuan Biotechnology Co., Ltd., acid protease is purchased from Shandong Yatu Biotechnology Co., Ltd., fish collagen protein is purchased from Shandong Runxin Biotechnology Co., Ltd., strawberry powder is purchased from Tianjin Jianfeng Natural Product Research and Development Co., Ltd., pomegranate powder is purchased from Tianjin Jianfeng Natural Product Research and Development Co., Ltd., cherry powder is purchased from Shaanxi Jiahe Biological Technology Co., Ltd., inulin powder is purchased from Inner Mongolia Weinihao Biological Technology Co., Ltd., mixed vegetable powder is purchased from Shanghai Gexin Foodstuff Technology Co., Ltd., carrot powder is purchased from Tianjin Xiugu Biological Technology Development Co., Ltd., polydextrose is purchased from Tate & Lyle Food Ingredients (Nantong) Co., Ltd., lactose is purchased from Denmark Arla Foods Ingredients, sweet orange powder essence is purchased from Suzhou Gaotian Spice Co., Ltd., potassium citrate is purchased from Jiangsu Jichao Biotechnology Co., Ltd., and sucralose is purchased from Shandong Kangbao Biochemical Technology Co., Ltd.

[0025] Preparation Example 1 Preparation of maca extract powder a1: pretreatment: remove the leaves and root hairs of fresh maca, wash clean, and cut into slices by a slicing machine; a2: grinding: grind the sliced maca through a grinder, and pass through a 60-mesh sieve to obtain maca powder; a3: take 0.8% of the mass of the composite enzyme of the maca powder (500g), add 10 times the mass of the maca powder to the composite enzyme to obtain a composite enzyme aqueous solution, and stir uniformly, wherein the composite enzyme is composed of pectinase and acid protease, and the mass ratio of the pectinase to the acid protease is 1:1.1; then add the composite enzyme aqueous solution to the maca powder (500g) to enzymatically hydrolyze the maca powder; the enzymatic hydrolysis temperature is controlled at 50℃, the pH is controlled at 3.5, and the enzymatic hydrolysis time is 2.5 hours to obtain an enzymatically hydrolyzed raw material; a4: separation: separation and collection of the enzymatic solution: after the enzymatic process is completed, 1 times the volume of the enzymatic raw material of pure water is added to the enzymatic raw material, stirred for 40 minutes, then centrifuged by a centrifuge to remove the precipitate, and the enzymatic solution is collected; a5: homogenization: the enzymatic solution is homogenized by a homogenizer to make the effective components of the enzymolysis more uniformly mixed with each other; a6: drying: the homogenized enzymatic solution is concentrated and then spray dried, the drying conditions are: inlet air temperature 220℃, liquid temperature 56℃, liquid flow rate 17.46ml / min, inlet air flow rate 5m 3 / min, to obtain the enzymatic maca extract powder; a7: screening: the dried enzymatic maca extract powder is screened through an 80-mesh sieve to obtain the maca extract powder.

[0026] Preparation Example 2 The preparation of the maca extract powder is different from that of Preparation Example 1 in that the preparation step a3 is different, and the mass of the pectinase in a3 is replaced by acid protease.

[0027] Specifically, 0.8% of the mass of the maca powder (500g) of acid protease is taken, 10 times the mass of the maca powder of pure water is added to the acid protease and stirred uniformly to obtain an acid protease aqueous solution, and then the acid protease aqueous solution is added to the maca powder (500g) to make the maca powder enzymolysis; the enzymolysis temperature is controlled at 50℃, the pH is controlled at 3.5, and the enzymolysis time is 2.5 hours to obtain the enzymatic raw material.

[0028] Preparation Example 3 The preparation of the maca extract powder is different from that of Preparation Example 1 in that the preparation step a3 is different, and the mass of the acid protease in a3 is replaced by pectinase.

[0029] Specifically, 0.8% of the mass of the maca powder (500g) of pectinase is taken, 1 times the mass of the maca powder of pure water is added to the pectinase and stirred uniformly to obtain a pectinase aqueous solution, and then the pectinase aqueous solution is added to the maca powder (500g) to make the maca powder enzymolysis; the enzymolysis temperature is controlled at 50℃, the pH is controlled at 3.5, and the enzymolysis time is 2.5 hours to obtain the enzymatic raw material.

[0030] Preparation Example 4 Preparation of sweet orange extract powder b1: 500g of dried sweet orange peel is crushed by a crusher and screened through a 60-mesh sieve to obtain sweet orange peel dry powder; b2: a 65(V / V)% concentration of edible ethanol solution is used as the extraction solvent, and the ratio of the amount of sweet orange peel powder to the amount of extraction solvent is 1g:10ml, which is added to a reflux extraction tank, heated, and reflux extracted for 3 times, each time for 2.5h, and the extraction liquid is combined; b3: The combined extract was recovered by rotary evaporator at 55°C under reduced pressure of -0.1 MPa to obtain a concentrated extract; b4: The concentrated extract was dried by a spray drying tower, inlet temperature: 180°C, outlet temperature 85°C, the powder in the drying tower was collected and sieved through an 80-mesh sieve to obtain sweet orange extract powder.

[0031] Example 1 A preparation method of a uric acid-lowering solid preparation, comprising the following steps: S1: The fish collagen, strawberry powder, pomegranate powder, cherry powder, chrysanthemum powder, mixed vegetable powder, carrot powder, polydextrose, lactose, sweet orange powder essence, potassium citrate, sucralose were pre-sieved through an 80-mesh sieve; S2: 175 g of the maca extract powder prepared in Preparation Example 1, 100 g of the sweet orange extract powder prepared in Preparation Example 4, 25 g of fish collagen, 10 g of strawberry powder, 220 g of polydextrose, 120 g of pomegranate powder, 100 g of cherry powder, 100 g of chrysanthemum powder, 85 g of lactose, 3 g of mixed vegetable powder, 10 g of sweet orange powder essence, 20 g of potassium citrate, 30 g of carrot powder, and 2 g of sucralose were weighed, and the above materials were put into a mixer and mixed for 25 minutes until completely uniform; S3: The mixed product was sieved through an 80-mesh sieve and immediately sealed and packaged, 7 g / bag; The mass ratio of the maca extract powder to the sweet orange extract powder was 1.75:1.

[0032] Example 2 A preparation method of a uric acid-lowering solid preparation, which is different from Example 1 in that in step S2, the total mass of the maca extract powder and the sweet orange extract powder is unchanged, and the mass ratio of the maca extract powder to the sweet orange extract powder is 4.5:1.

[0033] Specifically, step S2 is different, specifically, 225 g of the maca extract powder prepared in Preparation Example 1, 50 g of the sweet orange extract powder prepared in Preparation Example 4, 25 g of fish collagen, 10 g of strawberry powder, 220 g of polydextrose, 120 g of pomegranate powder, 100 g of cherry powder, 100 g of chrysanthemum powder, 85 g of lactose, 3 g of mixed vegetable powder, 10 g of sweet orange powder essence, 20 g of potassium citrate, 30 g of carrot powder, and 2 g of sucralose were weighed, and the above materials were put into a mixer and mixed for 25 minutes until completely uniform.

[0034] Example 3 A preparation method of a uric acid-lowering solid preparation, different from example 1 is that in step S2, the total mass of the maca extract powder and the sweet orange extract powder remains unchanged, and the mass ratio of the maca extract powder to the sweet orange extract powder is 0.83:1.

[0035] Specifically, step S2 is different, specifically, 125g of the maca extract powder prepared in preparation example 1, 150g of the sweet orange extract powder prepared in preparation example 4, 25g of fish collagen, 10g of strawberry powder, 220g of polydextrose, 120g of pomegranate powder, 100g of cherry powder, 100g of chrysanthemum powder, 85g of lactose, 3g of mixed vegetable powder, 10g of sweet orange powder essence, 20g of potassium citrate, 30g of carrot powder, and 2g of sucralose are weighed, and the above materials are put into a mixer and mixed for 25 minutes until completely uniform.

[0036] Example 4 A preparation method of a uric acid-lowering solid preparation, different from example 1 is that in step S2, the maca extract powder is the maca extract powder prepared by the preparation method of preparation example 2.

[0037] Example 5 A preparation method of a uric acid-lowering solid preparation, different from example 1 is that in step S2, the maca extract powder is the maca extract powder prepared by the preparation method of preparation example 3.

[0038] Comparative example 1 A preparation method of a uric acid-lowering solid preparation, different from example 1 is that in step S2, 175g of the maca extract powder prepared in preparation example 1 is replaced by an equal amount of the sweet orange extract powder prepared in preparation example 4.

[0039] Specifically, step S2 is different, specifically, 275g of the sweet orange extract powder prepared in preparation example 4, 25g of fish collagen, 10g of strawberry powder, 220g of polydextrose, 120g of pomegranate powder, 100g of cherry powder, 100g of chrysanthemum powder, 85g of lactose, 3g of mixed vegetable powder, 10g of sweet orange powder essence, 20g of potassium citrate, 30g of carrot powder, and 2g of sucralose are weighed, and the above materials are put into a mixer and mixed for 25 minutes until completely uniform.

[0040] Comparative example 2 A preparation method of a uric acid-lowering solid preparation, different from example 1 is that in step S2, 100g of the sweet orange extract powder prepared in preparation example 4 is replaced by an equal amount of the maca extract powder prepared in preparation example 1.

[0041] Specifically, step S2 is different, specifically, 275 g of the maca extract powder prepared in Preparation Example 1, 25 g of fish collagen, 10 g of strawberry powder, 220 g of polydextrose, 120 g of pomegranate powder, 100 g of cherry powder, 100 g of dandelion powder, 85 g of lactose, 3 g of mixed vegetable powder, 10 g of sweet orange powder essence, 20 g of potassium citrate, 30 g of carrot powder, and 2 g of sucralose are weighed, and the above materials are put into a mixer and mixed for 25 minutes until completely uniform.

[0042] Comparative Example 3 A preparation method of a uric acid-lowering solid preparation, which is different from Example 1 in that fish collagen is not added in step S2.

[0043] Comparative Example 4 A preparation method of a uric acid-lowering solid preparation, which is different from Example 1 in that pomegranate powder is not added in step S2.

[0044] Test Example 1: Inhibition of xanthine oxidase activity in vitro 1. Test method: The compositions prepared in Examples 1-5 and Comparative Examples 1-4 are dissolved in DMSO to prepare a 2 mg / mL solution, which is then diluted 10 times (0.2 mg / mL) with PBS buffer to obtain a sample solution to be tested.

[0045] 1 mg allopurinol is dissolved in 1 mL DMSO, and then diluted 180 times with PBS buffer to obtain an allopurinol solution as a positive control solution.

[0046] A 96-well plate is used for enzyme reaction, and 35 μL of 70 mM phosphate buffer, 50 μL of sample solution to be tested, and 50 μL of xanthine oxidase solution (0.01 U / mL) are sequentially taken and added to a reaction pool, and allopurinol solution is added to the positive control; the enzyme reaction compound is incubated at 37°C for 15 minutes, and then 50 μL of xanthine substrate solution (0.3 mM) is added and reacted at 25°C for 30 minutes, and then 25 μL of 1N HCl is added to terminate the reaction. The absorbance data of the solution in each reaction pool at 295 nm is read on a Bio-Tek enzyme reader. The inhibition rate of each sample is calculated.

[0047] Inhibition rate (%) = [(E 标准品 -E 样品 )] / E 标准品 × 100%.

[0048] Wherein, E 标准品 , E 样品 represents absorbance.

[0049] 2. Test results: The test results are shown in Table 1 Table 1: Inhibition of xanthine oxidase activity in vitro (enzyme labeling method) Group Inhibition rate (%) Example 1 89 Example 2 80 Example 3 85 Example 4 76 Example 5 78 Comparative Example 1 51 Comparative Example 2 46 Comparative Example 3 53 Comparative Example 4 58 Positive control solution 95 Test Example 2: Animal efficacy verification test for reducing uric acid 1. Test method: Healthy male SD rats weighing 180-200 g were observed for 3 days under normal feeding in the experimental environment, and then the test animals were randomly divided by weight into: blank control group, model control group, test groups 1-9, and positive drug group (benzbromarone); 10 rats in each group, with similar body weight distribution.

[0050] The blank control group was given distilled water 5.0 mL / kg by gavage in the morning every day, and the rest of the groups were given potassium oxonate 1.0 g / kg by gavage in the morning every day; the model control group was given distilled water by gavage in the afternoon, the positive drug group was given benzbromarone 14 mg / kg by gavage in the afternoon, and the test groups 1-9 were given the compositions of Example 1 to Example 5 and Comparative Examples 1-4 8.0 mg / kg by gavage in the afternoon, respectively. Once a day for 30 consecutive days.

[0051] Fasting for 12 hours (fasting without water restriction) before the formal test, and about 1 mL of blood was taken from the orbital venous plexus with a glass capillary before administration, and the serum was separated for detection of pre-drug serum uric acid level; blood was taken on the 30th day of administration, serum was separated to determine uric acid indicators, and the percentage of uric acid reduction was calculated.

[0052] 2. Test results: The test results are shown in Table 2.

[0053] Table 2: Serum uric acid levels in rats after 30 days of administration Group Uric acid level (μmol / L) Percentage of uric acid reduction (%) Blank control group 85.2±13.8 / Model control group 176.1±17.2 / Test 1 group (Example 1) 100.9±11.9 42.70 Test 2 group (Example 2) 121.6±14.2 30.95 Test 3 group (Example 3) 113.2±12.8 35.72 Test 4 group (Example 4) 132.1±16.1 24.98 Test 5 group (Example 5) 128.3±15.4 27.14 Test 6 group (Comparative Example 1) 140.7±17.6 20.10 Test 7 group (Comparative Example 2) 146.2±18.8 16.98 Test 8 group (Comparative Example 3) 138.1±20.3 21.58 Test 9 group (Comparative Example 4) 135.7±19.2 22.94 Positive drug group 113.6±19.7 35.49 Test Example 3: Case verification test for uric acid reduction efficacy 1. Test method: Test subjects with uric acid content greater than 420 μmol / L were tested as follows: Without taking other uric acid-lowering drugs, take the uric acid-lowering solid preparation prepared by the preparation method of Example 1 twice a day, empty stomach, morning and evening each time, 1 bag (7 g) each time, for 30 consecutive days.

[0054] 2. Test results: The test results are shown in Table 3.

[0055] Table 3: Serum uric acid levels in test subjects after 30 days of administration Results analysis and summary In combination with Examples 1-3 and Tables 1, 2, it can be seen that the mass ratio of the Maca extract powder to the sweet orange extract powder is different in Examples 1-3, the in vitro activity inhibition of xanthine oxidase is best in Example 1, the uric acid level is lowest in Example 1, and the percentage of lowering uric acid is also better than that in Examples 2-3.

[0056] In combination with Examples 1, 4-5 and Tables 1, 2, it can be seen that the in vitro activity inhibition of xanthine oxidase is lower than that in Example 1 in Examples 4-5, the uric acid level is higher than that in Example 1, and the percentage of lowering uric acid is also lower than that in Example 1. From the above, it can be seen that the effect of using pectinase and acid protease simultaneously to extract active substances from Maca is better than that of using pectinase or acid protease alone.

[0057] In combination with Example 1, Comparative Examples 1-2 and Tables 1, 2, it can be seen that the in vitro activity inhibition of xanthine oxidase is better, the uric acid level is lower, and the percentage of lowering uric acid is higher when the uric acid-lowering solid preparation contains both Maca extract powder and sweet orange extract powder than when it contains only Maca extract powder or only sweet orange extract powder.

[0058] In combination with Example 1, Comparative Examples 3-4 and Tables 1, 2, it can be seen that the in vitro activity inhibition of xanthine oxidase is poorer, the uric acid level is higher, and the percentage of lowering uric acid is lower when the uric acid-lowering solid preparation lacks fish collagen component or lacks pomegranate powder component.

[0059] In combination with Example 1 and Table 3, it can be seen that the uric acid-lowering solid preparation prepared by the preparation method of Example 1 has the efficacy of lowering uric acid.

[0060] The above are preferred embodiments of the present application, and do not limit the protection scope of the present application, so: any equivalent changes made according to the products, methods, principles of the present application should be covered within the protection scope of the present application.

Claims

1. A solid preparation for lowering uric acid, characterized in that: The invention is composed of the following raw materials in parts by weight: 0.125-0.225 parts of maca extract powder, 0.05-0.15 parts of sweet orange extract powder, 0.015-0.035 parts of fish collagen and 0.08-0.16 parts of pomegranate powder.

2. A uric acid-lowering solid preparation according to claim 1, characterized in that: The mass ratio of the maca extract powder to the sweet orange extract powder is (0.83-4.5):

1.

3. A uric acid-lowering solid preparation according to claim 1, characterized in that: The preparation method of the maca extract powder comprises the following preparation steps: a1： Pre-processing: remove the leaves and roots of fresh maca, wash and slice; a2: Grinding: Grind the flakes of maca into maca powder; a3: Take a complex enzyme, prepare a complex enzyme aqueous solution, add maca powder, and perform enzymolysis to obtain an enzymolysis raw material; a4: Separation: centrifugation, removal of precipitate, collection of enzymatic solution, homogenization; a5: Drying: Concentrate and dry the homogenized enzymatic solution to obtain the maca extract powder.

4. A uric acid-lowering solid preparation according to claim 3, characterized in that: In the step a3, the complex enzyme consists of pectinase and acid protease, and the mass ratio of pectinase to acid protease is 1:(1-1.2).

5. A uric acid-lowering solid preparation according to claim 3, characterized in that: In step a3, the mass of the complex enzyme is 0.8% of the mass of the maca powder, the enzymatic hydrolysis temperature is controlled at 45-55° C., the pH is controlled at 3-4, and the enzymatic hydrolysis time is 2-3 hours.

6. A uric acid-lowering solid preparation according to claim 3, characterized in that: In the step a5, the drying is spray drying.

7. The uric acid-lowering solid preparation according to claim 1, characterized in that: The preparation method of the sweet orange extract powder comprises the following preparation steps: b1: Grinding the dried sweet orange peel with a grinder to obtain sweet orange peel dry powder; b2: Use 60-70 (V / V)% edible ethanol solution as the extraction solvent, the ratio of sweet orange peel powder to extraction solvent is 1g: (10-15)mL, reflux extraction 2-4 times, each extraction time 2-3h, and combine the extracts; b3: concentrating the combined extracts to obtain a concentrated extract; b4: drying the concentrated extract to obtain the sweet orange extract powder.

8. The uric acid-lowering solid preparation according to claim 1, characterized in that: It also includes the following raw materials in parts by weight: 0.005-0.015 parts of strawberry powder, 0.05-0.15 parts of cherry powder, 0.05-0.15 parts of inulin, 0.002-0.004 parts of mixed vegetable powder, 0.02-0.04 parts of carrot powder, 0.005-0.015 parts of orange powder flavor, 0.01-0.03 parts of potassium citrate, 0.16-0.28 parts of polydextrose, 0.065-0.105 parts of lactose, and 0.001-0.003 parts of sucralose.

9. A method for preparing a uric acid-lowering solid preparation according to any one of claims 1 to 8, characterized in that: The method comprises the following preparation steps: S1: According to the weight ratio of each component, weigh maca extract powder, sweet orange extract powder, fish collagen, strawberry powder, polydextrose, pomegranate powder, cherry powder, inulin, lactose, mixed vegetable powder, sweet orange powder flavor, potassium citrate, carrot powder, and sucralose, and mix well; S2: Sealed packaging.

10. Use of the uric acid-lowering solid preparation according to claims 1 to 8 in the preparation of a medicament for preventing and / or treating hyperuricemia.

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