Double-jade sugar granules and preparation process thereof

Abstract

The invention provides double-jade sugar granules and a preparation process thereof, belongs to the technical field of sugar product preparation, and solves the technical problems that the existing double-jade sugar granules are low in preparation efficiency, cannot effectively reduce blood sugar and the like. The preparation process of the double-jade sugar granules comprises the following preparation steps: taking and adding materials; soaking raw materials; decocting for the first time; filtering for the first time and taking liquid; decocting for the second time; filtering for the second time and taking liquid; combining and concentrating; performing primary sieving; measuring the content; secondary charging and sieving; performing spray drying; granulating and finishing the granules; and packaging. The double-jade sugar granules are prepared by the preparation process. According to the process, the utilization rate of raw materials can be increased, the transfer rate of effective components of double decoction is high, the production energy consumption is low, the whole line is designed in a modularized mode, continuous production is supported, the production efficiency is high, the double-jade sugar granules can remarkably reduce postprandial blood sugar, improve traditional Chinese medicine syndromes, play a role in reducing blood sugar by adjusting the pancreas islet function, sugar absorption and metabolism utilization rate through multiple targets, and have a good application prospect. Especially, the effect on islet injury type diabetes mellitus is obvious.

Description

Technical Field

[0001] This invention belongs to the field of sugar product preparation technology, and relates to a double-jade sugar granule, and more particularly to a preparation process of double-jade sugar granules. Background Technology

[0002] Common bottlenecks in traditional Chinese medicine preparation production include: low extraction efficiency (only 55%-60% of the effective components are transferred in a single decoction, and high temperatures damage heat-sensitive components (such as polysaccharides and flavonoids); severe energy consumption and pollution (40% of the energy consumption of atmospheric pressure concentration, and wastewater COD (chemical oxygen demand) exceeding 5000 mg / L (10 times higher than the national standard); and low continuity (more than 50% equipment idle rate due to independent tank operation, with a single batch cycle of up to 12 hours).

[0003] In response to the stringent requirements of the 2020 edition of the Chinese Pharmacopoeia for the transfer rate and moisture content of granule components, this product integrates core technologies such as precise feeding with weighing sensors, two-stage filtration purification, and low-temperature spray drying, meeting GMP / ISO14001 standards. Through dry granulation and solvent recovery systems, it achieves the goal of green pharmaceutical manufacturing.

[0004] Existing production equipment lacks intelligent control, modular expansion, and closed-loop production, resulting in low production efficiency, high energy consumption, and an inability to effectively form a modular design for the entire production line.

[0005] Existing sugar-free granules are not effective in lowering blood sugar.

[0006] Based on this, we propose a double-corn sugar granule and its preparation process. Summary of the Invention

[0007] The purpose of this invention is to address the aforementioned problems in existing technologies by proposing a Shuangyutangke granule and its preparation process. The technical problem to be solved by this invention is: how to achieve efficient, stable, and low-energy production of Shuangyutangke granules, and ensure that Shuangyutangke granules can effectively lower blood sugar.

[0008] The objective of this invention can be achieved through the following technical solutions:

[0009] A type of double-codone granule and its preparation process, comprising the following preparation steps:

[0010] Step 1, Add ingredients: Add 20-30 parts by weight of yam, 20-30 parts by weight of kudzu root, 20-30 parts by weight of corn silk, 1-8 parts by weight of mulberry leaves, 10-15 parts by weight of Solomon's seal and 5-10 parts by weight of glutinous rice root to the first extraction tank;

[0011] Step 2, raw material soaking: Pour 12 times the total weight of all raw materials into the first extraction tank at room temperature and soak for 30 minutes to obtain the soaking mixture;

[0012] Step 3, initial decoction: Add all the soaked mixture from Step 2 to the second extraction tank, heat and decoct for 1.5 hours to obtain the initial decoction mixture;

[0013] Step 4, primary filtration and liquid extraction: The primary decoction mixture inside the second extraction tank is filtered to obtain primary filter residue and primary decoction liquid. The mixture is then filtered through a 100-mesh inclined sieve, and the output of the primary decoction liquid is recorded. The primary decoction liquid is injected into a single-effect concentrator, while the primary filter residue is left in the second extraction tank.

[0014] Step 5, Second decoction: Add 8 times the total weight of all raw materials to the second extraction tank and decoct the first filtered residue for 1 hour to obtain the second decoction mixture.

[0015] Step 6, secondary filtration and liquid extraction: The secondary decoction mixture inside the second extraction tank is filtered to obtain secondary filter residue and secondary decoction liquid. The mixture is filtered through a 100-mesh inclined screen, and the output of the secondary decoction liquid is recorded. The secondary decoction liquid is injected into a single-effect concentrator, and the secondary filter residue is placed in the second extraction tank. Then the secondary filter residue is discharged and the second extraction tank is cleaned.

[0016] Step 7, Concentration: The first and second decoctions are concentrated in a single-effect concentrator at 60-80℃ under reduced pressure to a relative density of 1.02-1.07. The relative density is measured at 60℃-65℃ to obtain the concentrated medicinal solution. After concentration, the volume or weight of the medicinal solution and the relative density are recorded.

[0017] Step 8, First sieving: Place the concentrated medicine solution in a metering filter and filter it through a 200-mesh inclined screen to obtain the first-filtered medicine solution and the first-filtered medicine residue remaining in the metering filter. During the first filtration process of the metering filter, the following data can be recorded: the volume or weight of the concentrated medicine solution entering, the volume or weight of the first-filtered medicine solution, and the weight of the first-filtered medicine residue calculated.

[0018] Step 9: Content determination: Take samples of the filtered liquid and determine its solid content and active ingredient content, and calculate the solid extraction rate and active ingredient transfer rate;

[0019] Step 10, Secondary Feeding and Sieving: Take 1 / 4 of the weight of the total solids in the first filtration solution of maltodextrin, 1-4 parts by weight of sucralose, and 6 times the weight of the sum of the weights of maltodextrin and sucralose in room temperature water into the third extraction tank. After stirring and dissolving, add the first filtration solution into the third extraction tank, stir well, and filter through a 200-mesh inclined sieve to obtain the second filtration solution and the second filtration residue remaining in the third extraction tank.

[0020] Step 11, spray drying: The secondary filtered drug solution is introduced into a spray dryer for spray drying. The inlet air temperature is 140-150℃, the outlet air temperature is 86-90℃, and the spray speed is 50-60 rpm. After spraying, a dry extract powder is obtained. The dry extract powder is weighed and the weight is recorded. Samples are taken to measure the content of active ingredients and the moisture content. The yield of the dry extract and the transfer rate of active ingredients are calculated.

[0021] Step 12, Granulation and Sizing: Add the dry paste powder and maltodextrin (1 / 4 the weight of the dry paste powder) to a mixer and mix well to obtain a mixed dry material. Then, feed the mixed dry material into a dry granulator for dry granulation. The extrusion pressure is 28-30 MPa, the extrusion speed is 8 r / min, and the material transfer speed is 15 r / min to obtain sugar granules. Then, place the sugar granules into a granulator for granulation to obtain the finished Shuangyu sugar granules.

[0022] Step 13, Packaging: The finished sugar granules are fed into the packaging machine and packaged into bags.

[0023] The equipment used in steps one through eleven includes a single-effect concentrator, a metering filter, and a spray dryer arranged sequentially. The single-effect concentrator and the metering filter have extraction supports on their sides. The extraction supports have three equally spaced extraction tanks and two equally spaced liquid pumps. The three extraction tanks are respectively designated as the first extraction tank, the second extraction tank, and the third extraction tank. The extraction supports also have three transfer pump stations located below the extraction tanks. The first liquid pump is connected to both the second extraction tank and the single-effect concentrator, and the second liquid pump is connected to both the third extraction tank and the spray dryer. The single-effect concentrator and the metering filter are connected via pipes, and the metering filter and the third extraction tank are connected via pipes.

[0024] Using the above structure, the following steps are performed: Add 20-30 parts by weight of yam, 20-30 parts by weight of kudzu root, 20-30 parts by weight of corn silk, 1-8 parts by weight of mulberry leaf, 10-15 parts by weight of Solomon's seal and 5-10 parts by weight of glutinous rice root to the first extraction tank.

[0025] Raw material soaking: Pour 12 times the total weight of all raw materials into the first extraction tank at room temperature and soak for 30 minutes to obtain the soaking mixture;

[0026] First decoction: Open the first extraction tank, and the soaking mixture falls into the transfer pump station below the first extraction tank. The transfer pump station 2 pumps all the soaking mixture into the second extraction tank, heats and decocts for 1.5 hours to obtain the first decoction mixture;

[0027] First filtration and liquid extraction: The first decoction mixture inside the second extraction tank is filtered to obtain the first filter residue and the first decoction liquid. The mixture is filtered through a 100-mesh inclined screen, and the output of the first decoction liquid is recorded. The first pump injects the first decoction liquid into the single-effect concentrator, and the first filter residue is left in the second extraction tank.

[0028] Secondary decoction: Add 8 times the total weight of all raw materials to the second extraction tank and decoct the first-filtered residue for 1 hour to obtain the secondary decoction mixture.

[0029] Secondary filtration and liquid extraction: The secondary decoction mixture inside the second extraction tank is filtered to obtain secondary filter residue and secondary decoction liquid. The mixture is filtered through a 100-mesh inclined screen, and the output of the secondary decoction liquid is recorded. The first pump injects the secondary decoction liquid into the single-effect concentrator. The secondary filter residue is placed in the second extraction tank. Then the secondary filter residue is discharged and the second extraction tank is cleaned.

[0030] Combined concentration: The first decoction and the second decoction are concentrated in a single-effect concentrator at 60-80℃ under reduced pressure to a relative density of 1.02-1.07. The relative density is measured at 60℃-65℃ to obtain the concentrated medicine. After the concentration is completed, the volume or weight of the medicine and the relative density are recorded.

[0031] One-time sieving: By placing the concentrated medicine solution in a metering filter and filtering it through a 200-mesh inclined screen, a first-time filtered medicine solution and a first-time filtered medicine residue remaining in the metering filter are obtained. During the first-time filtration process of the metering filter, the following data can be recorded: the volume or weight of the concentrated medicine solution entering, the volume or weight of the first-time filtered medicine solution, and the weight of the first-time filtered medicine residue calculated.

[0032] Content determination: Samples of the filtered liquid were taken and tested to determine the solid content and active ingredient content, and the solid extraction rate and active ingredient transfer rate were calculated.

[0033] Secondary feeding and sieving: Take 1 / 4 of the weight of the total solids of the first filtration solution, 1-4 parts by weight of sucralose, and 6 times the weight of the sum of the weights of maltodextrin and sucralose, and add them to the third extraction tank. Stir to dissolve, then add the first filtration solution to the third extraction tank, stir well, and filter through a 200-mesh inclined sieve to obtain the second filtration solution and the second filtration residue remaining in the third extraction tank.

[0034] Spray drying: The second pump draws the secondary filtered liquid into the spray dryer for spray drying. The inlet air temperature is 140-150℃, the outlet air temperature is 86-90℃, and the spray speed is 50-60 rpm. After spraying, a dry powder is obtained. The dry powder is weighed and the weight is recorded. Samples are taken to measure the content of active ingredients and the moisture content. The yield of the dry powder and the transfer rate of active ingredients are calculated.

[0035] The upper end of the extraction bracket has three equally spaced clearance holes. The extraction bracket is equipped with three sets of circumferentially distributed weighing sensors, with four weighing sensors in each set. The upper end of the extraction bracket is equipped with a guardrail.

[0036] With the above structure, the clearance hole facilitates the installation and connection of the extraction tank, the weighing sensor is used to install the extraction tank and measure the weight of the material inside the extraction tank, and the guardrail forms a physical barrier at the top of the extraction support to prevent operators, small tools or parts from accidentally falling from the top of the extraction support.

[0037] The extraction tank includes an extraction tank body. A stirring frame is rotatably mounted inside the extraction tank body. A stirring motor is fixed to the upper end of the extraction tank body, and the output shaft of the stirring motor is fixedly connected to the rotating shaft of the stirring frame. Several feeding cylinders and injection pipes are provided at the upper end of the extraction tank body. An insulation layer is provided on the outside of the extraction tank body. Several circulation pipes are provided on the outside of both the extraction tank body and the insulation layer. Several circulation pipes connected to the extraction tank body penetrate the insulation layer. Four circumferentially distributed mounting seats are fixed to the upper part of the outer side of the insulation layer. The mounting seats are fixed to the upper ends of corresponding weighing sensors. Two symmetrically arranged hinged seats are fixed to the lower part of the outer side of the insulation layer. A flip-top seat is fixed to the lower end of the insulation layer. A bottom flip-top is hinged to the flip-top seat. Symmetrically arranged bases are fixed to both sides of the bottom flip-top. A flip-top electric push rod is hinged between the base and the hinged seat on the same side. A sealing ring and a locking ring are rotatably mounted at the lower end of the insulation layer. On the inner side of the locking ring, several circumferentially distributed locking grooves are provided. Two symmetrically arranged rotating electric push rods are provided at the bottom of the outer side of the insulation layer. The telescopic ends of the rotating electric push rods are hinged to the locking ring. Both ends of the rotating shaft of the flip cover seat and the bottom flip cover are provided with liquid extraction pipes. The liquid inlet end of the liquid extraction pipe is connected to the bottom of the bottom flip cover, and the liquid outlet end of the liquid extraction pipe is connected to the liquid extraction pump. An inclined screen is fixed at the upper end of the bottom flip cover. A baffle ring plate with a notch on one side is fixed at the upper end of the bottom flip cover. The inclined screen is located inside the baffle ring plate. A semi-circular spray ring is fixed at the top side of the inclined screen. Several evenly distributed nozzles are provided on the inner side of the spray ring. The nozzles are directly opposite the notch. A high-pressure inlet pipe is connected to the lower end of the spray ring. The high-pressure inlet pipe extends through and out of the bottom flip cover. A ring of evenly distributed locking rod wheels is provided on the outside of the bottom flip cover. The position and number of locking rod wheels correspond to the locking grooves.

[0038] Using the above structure, the insulation layer wraps around the main body of the extraction tank to maintain a stable internal temperature; the circulation pipe runs through the insulation layer and connects to the tank body, connecting the external circulation system with the energy exchange of the material inside the tank; the main body of the extraction tank is fixed to the weighing sensor by four evenly distributed mounting seats around the circumference, monitoring the weight of the material in real time; the lower hinge seat is connected to the electric push rod of the flip cover, controlling the opening and closing of the bottom flip cover. The electric push rod of the flip cover pushes the bottom flip cover to rotate around the flip cover seat, realizing the opening and closing; the rotating electric push rod pushes out to drive the locking ring to rotate, and the locking groove on it meshes with the locking rod wheel of the bottom flip cover, mechanically locking the bottom flip cover through the inclined surface; when draining, the rotating electric push rod retracts to drive the locking ring to rotate in the opposite direction, unlocking the lock; the sealing ring is located inside the locking ring, ensuring... Ensures a tight seal when the bottom flap is closed; Feeding: Materials and solvents are added through the top feeding cylinder and injection pipe. The output shaft of the stirring motor drives the rotating shaft of the stirring frame to rotate, and the stirring frame stirs the materials inside the extraction tank; Solid-liquid separation: The inclined screen filters the materials, and the liquid flows into the bottom flap through the screen holes. The liquid is then pumped out by the corresponding pump through the liquid extraction pipe of the bottom flap. The baffle ring restricts the material range, and its opening facilitates the directional discharge of residue; Residue cleaning: The high-pressure inlet pipe is connected to an external air pump or water pump. Air is sprayed or liquid is supplied through the high-pressure inlet pipe. The high-pressure spray ring sprays high-pressure air or cleaning liquid through the nozzle. The high-pressure air spray discharges the residue from the opening, or the cleaning liquid sprays to flush the inclined screen to prevent clogging.

[0039] The inclined screens inside the second and third extraction tanks have apertures of 100 mesh and 200 mesh, respectively.

[0040] Using the above structure, inclined screens with different aperture sizes are used to screen the required particle size, meeting the process requirements of the preparation.

[0041] The transfer pump station includes a supporting receiving cylinder, a transfer pump, and a pump box. A connecting pipe connects the inlet end of the supporting receiving cylinder and the pump box. The supporting receiving cylinder is located directly below the main body of the extraction tank. The outlet end of the pump box is connected to the inlet end of the transfer pump. The transfer pump is connected to the feeding cylinder at the corresponding position.

[0042] With the above structure, the material receiving and temporary storage are achieved by supporting the receiving cylinder, which is located directly below the main body of the extraction tank. It directly receives the residue or slurry discharged from the extraction tank. The main body of the extraction tank discharges the material through the bottom flap. After the material falls into the supporting receiving cylinder by gravity, it flows into the pump box for temporary storage through the connecting pipe. Pumping and transfer: The transfer pump draws the material from the discharge end of the pump box, pressurizes it and transports it to the feeding cylinder at the top of the corresponding extraction tank.

[0043] The single-effect concentrator includes a concentrator support, on which a heater, an evaporation chamber, a cooler, and a concentrator condenser are connected in sequence. Both the heater and the evaporation chamber are provided with heat insulation layers. A filter screen is provided at the connection between the evaporation chamber and the cooler. A filter connector is provided between the cooler and the concentrator condenser.

[0044] Using the above structure, the heating and evaporation process is as follows: The material first enters the heater and is heated to its boiling point by heat transfer oil, initially evaporating some of the solvent; the high-temperature material then enters the evaporation chamber, where it evaporates violently under low or normal pressure, and the solvent vaporizes and separates; gas-liquid separation and filtration: The evaporated gas-liquid mixture passes through a primary filter screen at the outlet of the evaporation chamber to intercept entrained solid impurities or foam; the steam enters the cooler for pre-condensation and is further filtered through a filter connector to remove trace residual impurities; condensation and collection: The purified steam enters the concentrator and condenser to be completely condensed into a liquid, achieving the final separation of the solute and solvent; the concentrated high-purity solute solution is discharged from the bottom of the concentrator and condenser.

[0045] The metering filter includes a filter frame, an electrical control box, a filter cylinder, and a filter pump. A metering valve is provided between the inlet end of the filter pump and the filter cylinder. The electrical control box is electrically connected to the filter pump and the metering valve respectively. The filter screen inside the filter cylinder has a mesh size of 200 mesh.

[0046] Using the above structure, precision filtration is achieved: the concentrated medicine first enters the filter cartridge, where the internal filter screen intercepts solid particles or impurities, achieving fine purification of the liquid; metering control: the filtered liquid has its flow rate regulated by a metering valve and is pressurized and output by a filter pump to ensure delivery accuracy; intelligent regulation: the electrical control box monitors the system in real time: it adjusts the start / stop / speed of the filter pump to control the output pressure; and it dynamically controls the opening of the metering valve to precisely manage the flow rate.

[0047] The spray dryer includes a platform frame, an electrically heated thermal oil furnace, a chiller box, an exhaust fan, a storage tank, and a collection tank. A ladder is provided on the side of the platform frame. A spray drying cylinder, an expansion tank, a high-temperature high-efficiency filter, a steam fan, and primary and secondary efficiency filters are fixed on the platform frame. The air inlet of the steam fan is connected to the primary and secondary efficiency filters, and the air outlet of the steam fan is equipped with a steam heater. The oil outlet of the steam heater and its corresponding circulation pipe are connected to the oil return end of the electrically heated thermal oil furnace via oil pipes. An oil pump is connected to the oil outlet of the electrically heated thermal oil furnace, and the oil pump is connected to the oil inlet of the steam heater and its corresponding circulation pipe. The circulating pipes at each location are connected by oil pipes. Both oil pipes are connected to the expansion tank via pipelines. The high-temperature high-efficiency filter is connected to the upper end of the steam heater. The high-temperature high-efficiency filter is connected to the spray drying cylinder via a pipeline. The collection tank is connected to the lower end of the spray drying cylinder. The chiller box is connected to the drying condenser via a pipeline. The air inlet of the exhaust fan is connected to the storage tank. The air outlet of the exhaust fan is connected to an exhaust pipe. The drying condenser is connected to the storage tank. A spiral settling device is installed between the drying condenser and the spray drying cylinder. The lower discharge end of the spiral settling device is connected to the collection tank.

[0048] Using the above structure, the hot air system consists of: an electrically heated thermal oil furnace generating high-temperature thermal oil, which is circulated to a steam heater via an oil pump to heat the steam heater and also enters the insulation layer through the corresponding circulation pipe for boiling treatment; air, after being purified by a primary and secondary efficiency filter, enters and is sent to the steam heater by a steam blower for heating; an expansion tank regulates the volume change of the thermal oil to stabilize the system pressure; the heated air undergoes deep dust removal through a high-temperature high-efficiency filter to form sterile high-temperature hot air, which is then introduced into the spray drying cylinder; the atomized drying liquid is sprayed into the spray drying cylinder through an atomizer, and instantly dehydrated upon contact with the hot air to form powder; heavier particles fall into the collection tank through the spray drying cylinder, while lighter powder is carried by the drying airflow into a spiral settling device; large powder particles settle directly into the collection tank due to gravity; fine powder enters the drying condenser with the airflow, and after condensation and dehumidification, falls into the storage tank; exhaust gas treatment: the drying exhaust gas is drawn in by an exhaust fan and discharged through an exhaust pipe, meeting environmental protection requirements.

[0049] A finished sugar granule product prepared using a double-jaw sugar granule preparation process.

[0050] Compared with existing technologies, this Shuangyutang granule has the following advantages:

[0051] It can significantly reduce postprandial blood glucose and improve TCM syndrome, but its effect on HbA1c needs to be verified by a longer course of treatment; it exerts its hypoglycemic effect by regulating pancreatic function, glucose absorption and metabolic utilization through multiple targets, and is particularly effective for pancreatic islet damage type diabetes.

[0052] The preparation process of this Shuangyutang granule has the following advantages:

[0053] Gradient extraction for high efficiency and material savings: Employing a single initial decoction followed by a second deep decoction enhances the transfer rate of effective components from both decoctions; combined with graded filtration using inclined screens, it maximizes the retention of active substances and improves raw material utilization; Low-temperature energy saving and strict quality control: Reduced pressure concentration protects heat-sensitive components and reduces energy consumption; Four-level quality control nodes: decoction volume → concentrated density → solids detection → moisture content of dried extract, ensuring minimal deviation of effective components and batch consistency; Solvent recovery system and spray drying exhaust gas purification: Primary and secondary efficiency + high-temperature high-efficiency dual-stage filtration reduces wastewater emissions and promotes low-carbon environmental protection.

[0054] The extraction section is intelligent and reliable: a weighing sensor group monitors the feeding in real time with minimal error; a mechanical locking system for the inclined chute allows for fast opening and closing; three tanks with separate functions (soaking, boiling, and mixing) support continuous production; dual-stage protection for concentration and purification: a coarse filter in the evaporation chamber plus a fine filter connector provides dual-stage interception, reducing the failure rate; stepped thermal management: heating-evaporation-cooling-condensation improves thermal energy utilization; a spiral settler collects coarse powder and condensation captures fine powder, resulting in a high total powder yield; modular expansion and convenient operation and maintenance: flexible series connection of transfer pump stations increases production capacity; the modular design of the entire line supports rapid production changeover and improves overall capacity. Attached Figure Description

[0055] Figure 1 This is a schematic diagram showing the process details of the present invention.

[0056] Figure 2 This is a schematic diagram of the process flow of the present invention.

[0057] Figure 3 This is a schematic diagram of the preparation equipment in this invention.

[0058] Figure 4 This is a schematic diagram of the structure of some components in the preparation equipment of the present invention.

[0059] Figure 5 This is a schematic diagram of the upper three-dimensional structure of the extraction tank in this invention.

[0060] Figure 6 This is a schematic diagram of the lower three-dimensional structure of the extraction tank in this invention.

[0061] Figure 7 This is a schematic diagram of the material transfer pump assembly in this invention.

[0062] Figure 8 This is a schematic diagram of the single-effect concentrator in this invention.

[0063] Figure 9 This is a schematic diagram of the metering filter in this invention.

[0064] Figure 10 This is a three-dimensional structural diagram of the spray dryer in this invention.

[0065] Figure 11 This is a three-dimensional structural diagram of the spray dryer in this invention on the right side.

[0066] Figure 12 This is the medical evaluation and testing form for the Shuangyutangke granules of the present invention.

[0067] Figure 13 This is a test table for evaluating the hypoglycemic effect of the animal model of the present invention.

[0068] In the diagram, 1. Extraction support; 2. Transfer pump station; 3. Extraction tank; 4. Single-effect concentrator; 5. Metering filter; 6. Spray dryer; 7. Liquid pump; 8. Guardrail; 9. Clearance hole; 10. Weighing sensor; 11. Insulation layer; 12. Extraction tank body; 13. Circulation pipe; 14. Mounting base; 15. Feeding cylinder; 16. Hinge base; 17. Flip-top electric push rod; 18. Locking ring; 19. Locking groove; 20. Material baffle plate; 21. Base; 22. Bottom flip-top; 23. Liquid extraction pipe; 24. Rotary electric push rod; 25. High-pressure inlet pipe; 26. Flip-top base; 27. Locking rod wheel; 28. Inclined screen; 29. ​​Spray ring; 30. Support 31. Feeding cylinder; 32. Splash guard; 33. Connecting pipe; 34. Transfer pump; 35. Pump box; 36. Concentrator support; 37. Heater; 38. Evaporation chamber; 39. Cooler; 40. Concentrator condenser; 41. Filter connector; 42. Filter rack; 43. Electrical control box; 44. Filter cartridge; 45. Filter pump; 46. Ladder; 47. Platform frame; 48. Spray drying cylinder; 49. Drying condenser; 50. Exhaust pipe; 51. Expansion tank; 52. High-temperature high-efficiency filter; 53. Electric heating thermal oil furnace; 54. Steam fan; 55. Primary and secondary filters; 56. Chiller box; 57. Exhaust fan; 58. Storage tank; 59. Collection tank. Detailed Implementation

[0069] The following are specific embodiments of the present invention, which are described in conjunction with the accompanying drawings. However, the present invention is not limited to these embodiments.

[0070] like Figure 1-Figure 2 As shown, the preparation process of this double-coated sugar granules includes the following steps:

[0071] Step 1, Add ingredients: Add 20-30 parts by weight of yam, 20-30 parts by weight of kudzu root, 20-30 parts by weight of corn silk, 1-8 parts by weight of mulberry leaves, 10-15 parts by weight of Solomon's seal and 5-10 parts by weight of glutinous rice root to the first extraction tank;

[0072] Step 2, raw material soaking: Pour 12 times the total weight of all raw materials into the first extraction tank at room temperature and soak for 30 minutes to obtain the soaking mixture;

[0073] Step 3, initial decoction: Add all the soaked mixture from Step 2 to the second extraction tank, heat and decoct for 1.5 hours to obtain the initial decoction mixture;

[0074] Step 4, primary filtration and liquid extraction: The primary decoction mixture inside the second extraction tank is filtered to obtain primary filter residue and primary decoction liquid. The mixture is then filtered through a 100-mesh inclined sieve, and the output of the primary decoction liquid is recorded. The primary decoction liquid is injected into a single-effect concentrator, while the primary filter residue is left in the second extraction tank.

[0075] Step 5, Second decoction: Add 8 times the total weight of all raw materials to the second extraction tank and decoct the first filtered residue for 1 hour to obtain the second decoction mixture.

[0076] Step 6, secondary filtration and liquid extraction: The secondary decoction mixture inside the second extraction tank is filtered to obtain secondary filter residue and secondary decoction liquid. The mixture is filtered through a 100-mesh inclined screen, and the output of the secondary decoction liquid is recorded. The secondary decoction liquid is injected into a single-effect concentrator, and the secondary filter residue is placed in the second extraction tank. Then the secondary filter residue is discharged and the second extraction tank is cleaned.

[0077] Step 7, Concentration: The first and second decoctions are concentrated in a single-effect concentrator at 60-80℃ under reduced pressure to a relative density of 1.02-1.07. The relative density is measured at 60℃-65℃ to obtain the concentrated medicinal solution. After concentration, the volume or weight of the medicinal solution and the relative density are recorded.

[0078] Step 8, First sieving: Place the concentrated medicine solution in a metering filter and filter it through a 200-mesh inclined screen to obtain the first-filtered medicine solution and the first-filtered medicine residue remaining in the metering filter. During the first filtration process of the metering filter, the following data can be recorded: the volume or weight of the concentrated medicine solution entering, the volume or weight of the first-filtered medicine solution, and the weight of the first-filtered medicine residue calculated.

[0079] Step 9: Content determination: Take samples of the filtered liquid and determine its solid content and active ingredient content, and calculate the solid extraction rate and active ingredient transfer rate;

[0080] Step 10, Secondary Feeding and Sieving: Take 1 / 4 of the weight of the total solids in the first filtration solution of maltodextrin, 2 parts by weight of sucralose, and 6 times the weight of the sum of the weights of maltodextrin and sucralose in room temperature water into the third extraction tank. After stirring and dissolving, add the first filtration solution into the third extraction tank, stir well, and filter through a 200-mesh inclined sieve to obtain the second filtration solution and the second filtration residue remaining in the third extraction tank.

[0081] Step 11, spray drying: The secondary filtered drug solution is introduced into a spray dryer for spray drying. The inlet air temperature is 140-150℃, the outlet air temperature is 86-90℃, and the spray speed is 50-60 rpm. After spraying, a dry extract powder is obtained. The dry extract powder is weighed and the weight is recorded. Samples are taken to measure the content of active ingredients and the moisture content. The yield of the dry extract and the transfer rate of active ingredients are calculated.

[0082] Step 12, Granulation and Sizing: Add the dry paste powder and maltodextrin (1 / 4 the weight of the dry paste powder) to a mixer and mix well to obtain a mixed dry material. Then, feed the mixed dry material into a dry granulator for dry granulation. The extrusion pressure is 28-30 MPa, the extrusion speed is 8 r / min, and the material transfer speed is 15 r / min to obtain sugar granules. Then, place the sugar granules into a granulator for granulation to obtain the finished Shuangyu sugar granules.

[0083] Step 13, Packaging: The finished sugar granules are fed into the packaging machine and packaged into bags.

[0084] like Figures 3-11 As shown, the preparation process of this Shuangyutangke granules includes, in steps one through eleven, a single-effect concentrator 4, a metering filter 5, and a spray dryer 6 arranged sequentially. An extraction support 1 is provided on the side of the single-effect concentrator 4 and the metering filter 5. The extraction support 1 has three equally spaced extraction tanks 3 and two equally spaced liquid pumps 7. The three extraction tanks 3 are respectively designated as the first extraction tank, the second extraction tank, and the third extraction tank. Three transfer pump stations 2 are provided on the side of the extraction support 1, located below the extraction tanks 3. The first liquid pump 7 is connected to the second extraction tank and the single-effect concentrator 4, and the second liquid pump 7 is connected to the third extraction tank and the spray dryer 6. The single-effect concentrator 4 and the metering filter 5 are connected via pipes, and the metering filter 5 and the third extraction tank are connected via pipes.

[0085] Material preparation: Add 20-30 parts by weight of yam, 20-30 parts by weight of kudzu root, 20-30 parts by weight of corn silk, 1-8 parts by weight of mulberry leaves, 10-15 parts by weight of Solomon's seal, and 5-10 parts by weight of glutinous rice root to the first extraction tank; Raw material soaking: Pour 12 times the total weight of all raw materials into the first extraction tank at room temperature and soak for 30 minutes to obtain a soaked mixture; First decoction: Open the first extraction tank, and the soaked mixture falls into the transfer pump station 2 below the first extraction tank. The transfer pump station 2 pumps all the soaked mixture into the second extraction tank, heats and decocts for 1.5 hours to obtain a first decoction mixture; First filtration and liquid collection: Filter the first decoction mixture inside the second extraction tank to obtain a first-filtered residue and a first-decoction liquid. Filter through a 100-mesh inclined sieve and record the output volume of the first decoction liquid. A pump 7 injects the primary decoction into a single-effect concentrator 4, leaving the primary filter residue in a second extraction tank. Secondary decoction: Add 8 times the total weight of all raw materials to the second extraction tank at room temperature, and decoct the primary filter residue for 1 hour to obtain a secondary decoction mixture. Secondary filtration and extraction: Filter the secondary decoction mixture inside the second extraction tank to obtain secondary filter residue and secondary decoction liquid. Filter through a 100-mesh inclined sieve, record the output of the secondary decoction liquid, and the first pump 7 injects the secondary decoction liquid into the single-effect concentrator 4. Place the secondary filter residue in the second extraction tank, then discharge the secondary filter residue and clean the second extraction tank. Concentration and merging: Concentrate the primary and secondary decoction liquids in the single-effect concentrator 4 under reduced pressure at 60-80℃ to a relative density of 1.02-1.07. The relative density is measured at 60℃-65℃ to obtain a concentrated medicinal solution. After concentration, the volume or weight of the medicinal solution and the relative density are recorded. First sieving: The concentrated medicinal solution is placed in a metering filter 5 and filtered through a 200-mesh inclined screen to obtain a first-filtered medicinal solution and a first-filtered residue remaining in the metering filter 5. During the first filtration process in the metering filter 5, the following data can be recorded: the volume or weight of the entering concentrated medicinal solution, the volume or weight of the first-filtered medicinal solution, and the weight of the first-filtered residue calculated. Content determination: A sample of the first-filtered medicinal solution is taken to determine its solid content and active ingredient content, and the solid extraction rate and active ingredient transfer rate are calculated. Secondary feeding and sieving: A weight portion is taken as the total solid content of the first-filtered medicinal solution. Add 1 / 4 of the weight of maltodextrin, 2 parts by weight of sucralose, and 6 times the weight of the sum of the weights of maltodextrin and sucralose to the third extraction tank at room temperature. After stirring and dissolving, add the first-filtered solution to the third extraction tank, stir well, and filter through a 200-mesh inclined sieve to obtain a second-filtered solution and the second-filtered residue remaining in the third extraction tank. Spray drying: The second pump 7 introduces the second-filtered solution into the spray dryer 6 for spray drying. The inlet air temperature is 140-150℃, the outlet air temperature is 86-90℃, and the spray speed is 50-60 rpm. After spraying, a dry powder is obtained. Weigh the dry powder, record the weight, and take samples to determine the content of active ingredients and moisture content. Calculate the yield of the dry powder and the transfer rate of active ingredients.

[0086] The upper end of the extraction support 1 has three equidistant clearance holes 9. The extraction support 1 is equipped with three sets of circumferentially distributed load cells 10, with four load cells in each set. A guardrail 8 is located at the upper end of the extraction support 1. The clearance holes 9 facilitate the installation and connection of the extraction tank 3. The load cells 10 are used to install the extraction tank 3 and measure the weight of the material inside the extraction tank 3. The guardrail 8 forms a physical barrier at the upper end of the extraction support 1 to prevent operators, small tools, or parts from accidentally falling from the upper end of the extraction support 1.

[0087] The extraction tank 3 includes an extraction tank body 12. A stirring rack is rotatably mounted inside the extraction tank body 12. A stirring motor is fixed to the upper end of the extraction tank body 12, and the output shaft of the stirring motor is fixedly connected to the rotating shaft of the stirring rack. Several feeding cylinders 15 and liquid injection pipes are provided at the upper end of the extraction tank body 12. An insulation layer 11 is provided on the outside of the extraction tank body 12. Several circulation pipes 13 are provided on the outside of both the extraction tank body 12 and the insulation layer 11. These circulation pipes 13, connected to the extraction tank body 12, penetrate the insulation layer 11. The outer side of the insulation layer 11... Four circumferentially distributed mounting bases 14 are fixed to the upper part, and the mounting bases 14 are fixed to the upper ends of the corresponding weighing sensors 10. Two symmetrically arranged hinged seats 16 are fixed to the lower outer side of the insulation layer 11. A flip cover seat 26 is fixed to the lower end of the insulation layer 11. A bottom flip cover 22 is hinged to the flip cover seat 26. A symmetrically arranged base 21 is fixed to both sides of the bottom flip cover 22. A flip cover electric push rod 17 is hinged between the base 21 and the hinged seat 16 on the same side. A sealing ring and a locking ring 18 are rotatably provided at the lower end of the insulation layer 11. The sealing ring is located at... On the inner side of the locking ring 18, several circumferentially distributed locking grooves 19 are provided. Two symmetrically arranged rotating electric push rods 24 are rotatably arranged at the bottom outer side of the insulation layer 11. The telescopic ends of the rotating electric push rods 24 are hinged to the locking ring 18. Both ends of the rotating shafts of the flip cover base 26 and the bottom flip cover 22 are provided with liquid extraction pipes 23. The inlet end of the liquid extraction pipe 23 is connected to the bottom of the bottom flip cover 22, and the outlet end of the liquid extraction pipe 23 is connected to a liquid extraction pump 7. An inclined screen 28 is fixed to the upper end of the bottom flip cover 22. The upper end of 2 is fixed with a baffle ring plate 20 with a notch on one side. The inclined screen 28 is located inside the baffle ring plate 20. The top side of the inclined screen 28 is fixed with a semi-circular spray ring 29. The inner side of the spray ring 29 is provided with several equally spaced nozzles. The nozzles are directly opposite the notch. The lower end of the spray ring 29 is provided with a high pressure inlet pipe 25 connected to it. The high pressure inlet pipe 25 extends through and out of the bottom flip cover 22. The outer side of the bottom flip cover 22 is provided with a ring of evenly distributed locking rods 27. The position and number of locking rods 27 correspond to the locking groove 19.

[0088] Using the above structure, the insulation layer 11 wraps around the extraction tank body 12 to maintain a stable internal temperature; the circulation pipe 13 penetrates the insulation layer and connects to the tank body, connecting the external circulation system (such as heating / cooling medium) to exchange energy with the material inside the tank; the extraction tank body 12 is fixed to the weighing sensor 10 by four circumferentially distributed mounting seats 14 to monitor the material weight in real time; the lower hinge seat 16 is connected to the flip-top electric push rod 17 to control the opening and closing of the bottom flip-top 22. The flip-top electric push rod 17 pushes the bottom flip-top 22 to rotate around the flip-top seat 26 to achieve opening and closing; the rotating electric push rod 24 pushes out to drive the locking ring 18 to rotate, and the locking groove 19 on it engages with the locking lever wheel 27 of the bottom flip-top 22, mechanically locking the bottom flip-top 22 through the inclined surface; when draining, the rotating electric push rod 24 retracts to drive the locking ring 18 to rotate in the opposite direction, unlocking and locking; The sealing ring is located inside the locking ring 18 to ensure the sealing performance when the bottom flap 22 is closed; Feeding: Materials and solvents are added through the top feeding cylinder 15 and the liquid injection pipe. The output shaft of the stirring motor drives the rotating shaft of the stirring frame to rotate, and the stirring frame stirs the materials inside the extraction tank body 12; Solid-liquid separation: The inclined screen 28 filters the materials, and the liquid flows into the bottom flap 22 through the screen holes. The liquid is drawn out by the corresponding liquid pump 7 through the liquid extraction pipe 23 of the bottom flap 22. The baffle ring 20 restricts the range of materials, and its notch facilitates the directional discharge of residues; Residue cleaning: The high-pressure inlet pipe 25 is connected to an external air pump or water pump. Air is sprayed or liquid is supplied through the high-pressure inlet pipe 25. The high-pressure spray ring 29 sprays high-pressure air or cleaning liquid through the nozzle. The high-pressure air spray discharges the residues from the notch, or the cleaning liquid sprays to flush the inclined screen 28 to prevent blockage.

[0089] The inclined screens 28 inside the second and third extraction tanks have apertures of 100 mesh and 200 mesh, respectively. These inclined screens 28 with different aperture sizes are used to screen the particles to the required size, meeting the process requirements of the preparation.

[0090] The transfer pump station 2 includes a support receiving cylinder 30, a transfer pump 33, and a pump box 34. A connecting pipe 32 connects the inlet end of the support receiving cylinder 30 and the pump box 34. The support receiving cylinder 30 is located directly below the extraction tank body 12. The outlet end of the pump box 34 is connected to the inlet end of the transfer pump 33. The transfer pump 33 is connected to the feeding cylinder 15 at the corresponding position.

[0091] Material receiving and temporary storage: The supporting receiving cylinder 30 is located directly below the main body 12 of the extraction tank, directly receiving the residue or slurry discharged from the extraction tank. The main body 12 of the extraction tank discharges the material through the bottom flip cover 22. After the material falls into the supporting receiving cylinder 30 by gravity, it flows into the pump box 34 for temporary storage through the connecting pipe 32. Pumping and material transfer: The transfer pump 33 draws the material from the discharge end of the pump box 34, pressurizes it and transports it to the feeding cylinder 15 at the upper end of the corresponding extraction tank 3.

[0092] The single-effect concentrator 4 includes a concentrator support 35, on which a heater 36, an evaporation chamber 37, a cooler 38, and a concentrator condenser 39 are connected in sequence. Both the heater 36 and the evaporation chamber 37 are provided with heat insulation layers. A filter screen is provided at the connection between the evaporation chamber 37 and the cooler 38. A filter connector 40 is provided between the cooler 38 and the concentrator condenser 39.

[0093] Heating and Evaporation: The material first enters heater 36 (with heat insulation layer) and is heated to boiling point by heat transfer oil, initially evaporating some of the solvent; the high-temperature material then enters evaporation chamber 37 (with heat insulation layer) and evaporates violently under low or normal pressure, with solvent vaporization and separation; Gas-Liquid Separation and Filtration: The evaporated gas-liquid mixture passes through a primary filter screen at the outlet of evaporation chamber 37 to intercept entrained solid impurities or foam; the steam enters cooler 38 for pre-condensation and further passes through filter connector 40 (secondary filtration) to remove trace residual impurities; Condensation and Collection: The purified steam enters concentrator condenser 39 and is completely condensed into liquid (solvent), achieving the final separation of solute and solvent; the concentrated high-purity solute solution is discharged from the bottom of concentrator condenser 39.

[0094] The metering filter 5 includes a filter frame 41, on which an electrical control box 42, a filter cylinder 43, and a filter pump 44 are mounted. A metering valve is provided between the inlet end of the filter pump 44 and the filter cylinder 43. The electrical control box 42 is electrically connected to the filter pump 44 and the metering valve respectively. The filter screen inside the filter cylinder 43 has a mesh size of 200 mesh.

[0095] Precision filtration: The concentrated liquid first enters the filter cartridge 43, where the internal filter screen intercepts solid particles or impurities, achieving fine purification of the liquid; Metering control: The filtered liquid is regulated by a metering valve and pressurized by a filter pump 44 to ensure delivery accuracy; Intelligent control: The electrical control box 42 monitors the system in real time: it regulates the start / stop / speed of the filter pump and controls the output pressure; it dynamically controls the opening of the metering valve to accurately manage the flow rate (such as liters / minute or total batch volume).

[0096] The spray dryer 6 includes a platform frame 46, an electric heating thermal oil furnace 52, a chiller box 55, an exhaust fan 56, a storage tank 57, and a collection tank 58. A ladder 45 is provided on the side of the platform frame 46. A spray drying cylinder 47, an expansion tank 50, a high-temperature high-efficiency filter 51, a steam fan 53, and a primary and secondary efficiency filter 54 are fixed on the platform frame 46. The air inlet of the steam fan 53 is connected to the primary and secondary efficiency filter 54, and the air outlet of the steam fan 53 is equipped with a steam heater. The oil outlet of the steam heater and its corresponding circulation pipe 13 are connected to the oil return end of the electric heating thermal oil furnace 52 via oil pipes. An oil pump is connected to the oil outlet of the electric heating thermal oil furnace 52, and the oil pump is connected to the oil inlet of the steam heater and... The corresponding circulation pipes 13 are connected by oil pipes. Both oil pipes are connected to the expansion tank 50 by pipes. The high-temperature high-efficiency filter 51 is connected to the upper end of the steam heater. The high-temperature high-efficiency filter 51 is connected to the spray drying cylinder 47 by pipes. The collection tank 58 is connected to the lower end of the spray drying cylinder 47. The chiller box 55 is connected to the drying condenser 48 by pipes. The air inlet of the exhaust fan 56 is connected to the storage tank 57. The air outlet of the exhaust fan 56 is connected to the exhaust pipe 49. The drying condenser 48 is connected to the storage tank 57. A spiral setter is provided between the drying condenser 48 and the spray drying cylinder 47. The lower discharge end of the spiral setter is connected to the collection tank 58.

[0097] Hot air system: The electric heating thermal oil furnace 52 generates high-temperature thermal oil, which is circulated to the steam heater by the oil pump to heat the steam heater (up to 150~300℃). It also enters the insulation layer 11 through the corresponding circulation pipe 13 for boiling treatment. Air is purified by the primary and secondary efficiency filters 54 before entering and is sent to the steam heater by the steam blower 53 for heating. The expansion tank 50 regulates the volume change of the thermal oil to stabilize the system pressure. The heated air is deeply dusted by the high-temperature high-efficiency filter 51 to form sterile high-temperature hot air, which is then introduced into the spray drying cylinder 47. The atomized drying liquid (from the preceding equipment) is sprayed into the spray drying cylinder 47 through the atomizer. After contact with hot air, it is instantly dehydrated to form powder. Heavier particles fall into the collection tank 58 through the spray drying cylinder 47, while lighter powder is carried into the spiral settling tank by the drying airflow. Large powder particles settle directly into the collection tank 58 due to gravity. Fine powder enters the drying condenser 48 (cooled by the chiller box 55) with the airflow, and after condensation and dehumidification, it falls into the storage tank 57. Waste gas treatment: The drying exhaust gas is drawn by the exhaust fan 56 and discharged through the exhaust pipe 49, which meets environmental protection requirements.

[0098] This Shuangyutangke granule is a finished granule product prepared using the Shuangyutangke granule preparation process.

[0099] Example 1

[0100] Step 1, feeding and adding materials: Add 25 parts of yam, 25 parts of kudzu root, 25 parts of corn silk, 5 parts of mulberry leaves, 12.5 parts of Solomon's seal and 7.5 parts of glutinous rice root to the extraction tank body 12 of the first extraction tank through the feeding cylinder 15. The extraction tank body 12 is fixed to the weighing sensor 10 by four evenly distributed mounting bases 14 to monitor the weight of the added materials in real time.

[0101] Step 2, raw material soaking: 12 times the total weight of all raw materials is added to the main body 12 of the first extraction tank through the injection pipe of the first extraction tank. Soak for 30 minutes to obtain a soaking mixture. The output shaft of the stirring motor drives the rotating shaft of the stirring rack to rotate. The stirring rack stirs the material inside the main body 12 of the extraction tank to accelerate the soaking effect. The main body 12 of the extraction tank is fixed to the weighing sensor 10 by four circumferentially distributed mounting seats 14 to monitor the weight of water added in real time.

[0102] Step 3, initial decoction: The rotating electric push rod 24 of the first extraction tank retracts, driving the locking ring 18 to rotate in the opposite direction, unlocking and locking. The flip-top electric push rod 17 pushes the bottom flip-top 22 to rotate around the flip-top seat 26 and open. The high-pressure inlet pipe 25 is connected to an external air pump, and air is sprayed from the high-pressure inlet pipe 25. The high-pressure spray ring 29 sprays high-pressure air through the nozzle, and the high-pressure air discharges all the material on the inclined screen 28. (After the material is discharged, the high-pressure inlet pipe 25 is switched to connect to an external water pump, and liquid is supplied from the high-pressure inlet pipe 25. The high-pressure spray ring 29 sprays cleaning liquid through the nozzle, and the cleaning liquid washes the inclined screen 28 for cleaning. The waste residue and waste liquid fall into the support receiving cylinder 30 by gravity and then flow into the pump box 34 through the connecting pipe 32 for temporary storage. The transfer pump 33 draws the waste residue and waste liquid from the discharge end of the pump box 34 and pressurizes it for waste discharge treatment.) The soaking mixture is then removed. All the material falls into the support receiving cylinder 30. After falling into the support receiving cylinder 30 by gravity, the material flows into the pump box 34 through the connecting pipe 32 for temporary storage. The transfer pump 33 draws the material from the discharge end of the pump box 34, pressurizes and transports it to the feeding cylinder 15 at the upper end of the corresponding second extraction tank, and adds it all into the extraction tank body 12 of the second extraction tank. The electric heating heat transfer oil furnace 52 generates high temperature heat transfer oil, which is injected into the insulation layer 11 of the first extraction tank through the circulation pipe 13 at the corresponding position by the oil pump for decocting. The heating and decocting is carried out for 1.5 hours to obtain a decocted mixture. The output shaft of the stirring motor drives the rotating shaft of the stirring rack to rotate. The stirring rack stirs the material inside the extraction tank body 12 to accelerate the decocting effect. The extraction tank body 12 is fixed on the weighing sensor 10 by four circumferentially distributed mounting seats 14 to monitor the total weight in real time.

[0103] Step 4, primary filtration and liquid extraction: The primary decoction mixture is filtered through the inclined screen 28 of the second extraction tank, and the primary filter residue is placed on the upper part of the inclined screen 28. The primary decoction liquid is extracted and discharged by the corresponding pump 7 through the extraction pipe 23 of the bottom flip cover 22 and injected into the heater 36 of the single-effect concentrator 4. The main body 12 of the extraction tank is fixed on the weighing sensor 10 by four circumferentially distributed mounting seats 14 to monitor and record the output of the primary decoction liquid in real time.

[0104] Step 5, Secondary Decoction: Add room temperature water equal to 8 times the total weight of all raw materials to the extraction tank body 12 of the second extraction tank through the injection pipe of the second extraction tank. The extraction tank body 12 is fixed to the weighing sensor 10 by four evenly distributed mounting bases 14, which monitor the weight of water added in real time. The electric heating heat transfer oil furnace 52 generates high temperature heat transfer oil, which is circulated into the insulation layer 11 of the second extraction tank through the corresponding circulation pipe 13 via the oil pump for decoction. The first-filtered residue is decocted for 1 hour to obtain the secondary decoction mixture. The output shaft of the stirring motor drives the rotating shaft of the stirring rack to rotate, and the stirring rack stirs the material inside the extraction tank body 12 to accelerate the decoction effect.

[0105] Step Six, Secondary Filtration and Liquid Extraction: The secondary decoction mixture is filtered through the inclined screen 28 of the second extraction tank, and the resulting primary filter residue is placed on the upper part of the inclined screen 28. The secondary decoction liquid is drawn out by the first pump 7 at the corresponding position through the suction pipe 23 of the bottom flap 22 and injected into the heater 36 of the single-effect concentrator 4. The extraction tank body 12 is fixed to the weighing sensor 10 by four circumferentially distributed mounting seats 14 to monitor and record the output of the secondary decoction liquid in real time and to clean the second extraction tank. That is, the flip-top electric push rod 17 pushes the bottom flap 22 to rotate around the flap seat 26 to open. The high-pressure inlet pipe 25 is connected to an external air pump. Air is sprayed from the high-pressure inlet pipe 25, and the high-pressure spray ring 29 sprays high-pressure air through the nozzle. The high-pressure air sprays all the material on the inclined screen 28. Then, the high-pressure inlet pipe 25 is switched to connect to an external water pump. Liquid is supplied from the high-pressure inlet pipe 25, and the high-pressure spray ring 29 sprays cleaning liquid through the nozzle. The cleaning liquid washes the inclined screen 28 and cleans it. The waste residue and waste liquid fall into the support collection cylinder 30 by gravity and then flow into the pump box 34 through the connecting pipe 32 for temporary storage. The transfer pump 33 draws the waste residue and waste liquid from the discharge end of the pump box 34 and pressurizes it for waste discharge treatment.

[0106] Step 7, Concentration and Combination: The primary and secondary decoctions are concentrated in a single-effect concentrator 4. First, the decoction enters heater 36 (with insulation) and is heated to its boiling point by heat transfer oil, initially evaporating some of the solvent. The high-temperature material then enters evaporation chamber 37 (with insulation) for vigorous evaporation under low or normal pressure, resulting in solvent vaporization and separation. The evaporated gas-liquid mixture passes through a primary filter at the outlet of evaporation chamber 37 to intercept entrained solid impurities or foam. The steam enters cooler 38 for pre-condensation and further passes through filter connector 40 (secondary filtration) to remove trace residual impurities. The purified steam enters concentrator condenser 39 and is completely condensed into liquid (solvent), achieving final separation of solute and solvent. The concentrated high-purity solute solution is discharged from the bottom of concentrator condenser 39 and concentrated under reduced pressure at 60-80℃ to a relative density of 1.02-1.07. The relative density is measured at 60℃-65℃ to obtain the concentrated solution. After concentration, the volume or weight of the solution and the relative density are recorded (for testing).

[0107] Step 8, Primary Filtration: The first pump 7 pumps the concentrated medicine into the filter cylinder 43. The internal filter screen intercepts solid particles or impurities, achieving fine purification of the liquid, resulting in primary filtered medicine and primary filtered residue remaining in the metering filter. The flow rate of the primary filtered medicine is regulated by the metering valve and pressurized by the filter pump 44 for output. During the primary filtration process of the metering filter, the following data can be recorded through the metering valve: the volume or weight of the entering concentrated medicine, the volume or weight of the primary filtered medicine, and the weight of the primary filtered residue calculated by calculation.

[0108] Step 9: Content determination: Take samples of the filtered liquid and determine its solid content and active ingredient content, and calculate the solid extraction rate and active ingredient transfer rate;

[0109] Step 10, Secondary Feeding and Sieving: Take 1 / 4 of the total solids weight of the first-filtered liquid maltodextrin, 2 parts of sucralose, and 6 times the weight of the sum of maltodextrin and sucralose in room temperature water, respectively, and feed them into the extraction tank body 12 of the third extraction tank through the corresponding feeding cylinder 15 and injection pipe. After stirring and dissolving, the filtration pump 44 adds the first-filtered liquid to the third extraction tank. The output shaft of the stirring motor drives the rotating shaft of the stirring frame to rotate. The stirring frame stirs the material inside the extraction tank body 12. Filter it through a 200-mesh inclined screen 28 to obtain the secondary filtered liquid and the secondary filtered residue remaining in the third extraction tank. The secondary filtered liquid is drawn out by the second pump 7 at the corresponding position through the extraction pipe 23 of the bottom flap 22 and injected into the atomizer of the spray dryer 6.

[0110] Step 11, Spray Drying: The electrically heated thermal oil furnace 52 generates high-temperature thermal oil, which is circulated to the steam heater via an oil pump to raise the temperature of the steam heater (up to 150~300℃). It also enters the insulation layer 11 through the corresponding circulation pipe 13 for decoction treatment. Air, purified by the primary and secondary efficiency filters 54, enters and is sent to the steam heater by the steam blower 53 for heating. The expansion tank 50 regulates the volume change of the thermal oil to stabilize the system pressure. The heated air undergoes deep dust removal through the high-temperature high-efficiency filter 51, forming sterile high-temperature hot air, which is then introduced into the spray drying cylinder 47. The second liquid pump 7 guides the secondary filtered liquid into the atomizer of the spray dryer, spraying it into the spray drying cylinder 47 through the atomizer. Upon contact with the hot air, the liquid instantly... Dehydration is carried out to form powder. The inlet air temperature is 140-150℃, the outlet air temperature is 86-90℃, and the spray speed is 50-60 rpm. After spraying, dry powder is obtained. Heavier particles fall into the collection tank 58 through the spray drying cylinder 47. Lighter powder is carried into the spiral settling tank by the drying airflow. Large powder particles settle directly into the collection tank 58 due to gravity. Fine powder enters the drying condenser 48 (cooled by the chiller box 55) with the airflow. After condensation and dehumidification, it falls into the storage tank 57. Waste gas treatment: The drying exhaust gas is drawn by the exhaust fan 56 and discharged through the exhaust pipe 49, which meets environmental protection requirements. The dry powder is weighed, the weight is recorded, and samples are taken to measure the content of effective ingredients and moisture content. The dry powder yield and effective ingredient transfer rate are calculated.

[0111] Step 12, Granulation and Sizing: Add the dry paste powder and maltodextrin (1 / 4 the weight of the dry paste powder) to a mixer and mix well to obtain a mixed dry material. Then, feed the mixed dry material into a dry granulator for dry granulation. The extrusion pressure is 28-30 MPa, the extrusion speed is 8 r / min, and the material transfer speed is 15 r / min to obtain sugar granules. Then, place the sugar granules into a granulator for granulation to obtain the finished Shuangyu sugar granules.

[0112] Step 13, Packaging: The finished sugar granules are fed into the packaging machine and packaged into bags.

[0113] Example 2: The difference between Example 2 and Example 1 is that the weight parts of the raw materials are: 20 parts of yam, 20 parts of kudzu root, 20 parts of corn silk, 1 part of mulberry leaf, 10 parts of Solomon's seal and 5 parts of glutinous rice root.

[0114] Example 3; The difference between Example 3 and Example 1 is that the weight parts of the raw materials are: 30 parts of yam, 30 parts of kudzu root, 30 parts of corn silk, 8 parts of mulberry leaves, 15 parts of Solomon's seal, and 10 parts of glutinous rice root.

[0115] Comparative Example 1: The difference between Comparative Example 1 and Example 1 is that the weight parts of the raw materials used in the preparation are: 25 parts of yam, 25 parts of kudzu root, 0 parts of corn silk, 5 parts of mulberry leaves, 12.5 parts of Solomon's seal rhizome, and 7.5 parts of glutinous rice root.

[0116] Comparative Example 2: The difference between Comparative Example 2 and Example 1 is that the weight parts of the raw materials used in the preparation are as follows: 25 parts of yam, 25 parts of kudzu root, 25 parts of corn silk, 5 parts of mulberry leaves, 0 parts of Solomon's seal, and 7.5 parts of glutinous rice root.

[0117] Comparative Example 3: Blank control, no medication was administered.

[0118] (1) Medical evaluation test on the use of Shuangyutangke granules. Subjects: a total of 30 people, 15 males and 15 females, aged 22 to 53 years, with an average age of 30.5 years; meeting the subject voluntary inclusion criteria.

[0119] The Shuangyutangke granules prepared in Examples 1-3 and Comparative Examples 1-2 were subjected to performance testing. Clinical hypoglycemic effects were assessed by measuring fasting plasma glucose (FPG), 2-hour postprandial glucose (2hPG), glycated hemoglobin (HbA1c), and the improvement rate of TCM syndromes. The average values ​​were taken, and the test data are shown in the table below. Figure 12 As shown.

[0120] from Figure 12 As can be seen from the above, the Shuangyutangke granules of the present invention significantly reduce postprandial blood glucose and improve TCM syndrome, but the effect on HbA1c needs to be verified by a longer course of treatment.

[0121] (2) The hypoglycemic effect was evaluated in animal models. Subjects included: several alloxan-induced diabetic rats, several streptozotocin (STZ)-induced diabetic mice, several diabetic rats with hyperviscosity syndrome, and several Yin-deficiency model mice. The hypoglycemic effect was tested and the average value was taken. The test data is shown in the table below. Figure 13 As shown.

[0122] from Figure 13 As can be seen from the above, the Shuangyutangke granules of the present invention exert a hypoglycemic effect by regulating pancreatic function, sugar absorption and metabolic utilization through multiple targets, and have a significant effect on pancreatic islet damage type diabetes.

[0123] In summary, the advantages of the preparation process include: gradient extraction for high efficiency and material savings: employing a single initial decoction followed by a second deep decoction enhances the transfer rate of effective components from both decoctions; combined with graded filtration using inclined screens, it maximizes the retention of active substances and improves raw material utilization; low-temperature energy saving and strict quality control: reduced pressure concentration protects heat-sensitive components and reduces energy consumption; four-level quality control nodes: decoction volume → concentrated density → solids detection → moisture content of dried extract, ensuring minimal deviation of effective components and batch consistency; solvent recovery system and spray drying exhaust gas purification: primary and secondary efficiency + high-temperature high-efficiency dual-stage filtration reduces wastewater emissions and promotes low-carbon environmental protection.

[0124] Advantages of the equipment system: Intelligent and reliable extraction section: Weighing sensor group monitors feeding in real time with small error; inclined chute mechanical locking system for fast opening and closing speed; three tanks with separate functions (soaking, boiling, mixing) support continuous production; dual-stage protection for concentration and purification: coarse filtration in the evaporation chamber plus fine filtration connector for dual-stage interception, reducing failure rate; stepped thermal management: heating-evaporation-cooling-condensation to improve thermal energy utilization; spiral settler collects coarse powder and condenser captures fine powder, resulting in high total powder yield; modular expansion and convenient operation and maintenance: flexible series connection of transfer pump stations to increase production capacity; modular design of the entire line supports rapid production changeover and increases production capacity.

[0125] The specific embodiments described herein are merely illustrative of the spirit of the invention. Those skilled in the art to which this invention pertains may make various modifications or additions to the described specific embodiments or use similar methods to substitute them, without departing from the spirit of the invention or exceeding the scope defined by the appended claims.

Claims

1. A preparation process for double-coated sugar granules, characterized in that, The preparation steps include the following: Step 1, Add ingredients: Add 20-30 parts by weight of yam, 20-30 parts by weight of kudzu root, 20-30 parts by weight of corn silk, 1-8 parts by weight of mulberry leaves, 10-15 parts by weight of Solomon's seal and 5-10 parts by weight of glutinous rice root to the first extraction tank; Step 2, raw material soaking: Pour 12 times the total weight of all raw materials into the first extraction tank at room temperature and soak for 30 minutes to obtain the soaking mixture; Step 3, initial decoction: Add all the soaked mixture from Step 2 to the second extraction tank, heat and decoct for 1.5 hours to obtain the initial decoction mixture; Step 4, primary filtration and liquid extraction: The primary decoction mixture inside the second extraction tank is filtered to obtain primary filter residue and primary decoction liquid. The mixture is then filtered through a 100-mesh inclined sieve, and the output of the primary decoction liquid is recorded. The primary decoction liquid is injected into a single-effect concentrator, while the primary filter residue is left in the second extraction tank. Step 5, Second decoction: Add 8 times the total weight of all raw materials to the second extraction tank and decoct the first filtered residue for 1 hour to obtain the second decoction mixture. Step 6, secondary filtration and liquid extraction: The secondary decoction mixture inside the second extraction tank is filtered to obtain secondary filter residue and secondary decoction liquid. The mixture is filtered through a 100-mesh inclined screen, and the output of the secondary decoction liquid is recorded. The secondary decoction liquid is injected into a single-effect concentrator, and the secondary filter residue is placed in the second extraction tank. Then the secondary filter residue is discharged and the second extraction tank is cleaned. Step 7, Concentration: The first and second decoctions are concentrated in a single-effect concentrator at 60-80℃ under reduced pressure to a relative density of 1.02-1.

07. The relative density is measured at 60℃-65℃ to obtain the concentrated medicinal solution. After concentration, the volume or weight of the medicinal solution and the relative density are recorded. Step 8, First sieving: Place the concentrated medicine solution in a metering filter and filter it through a 200-mesh inclined screen to obtain the first-filtered medicine solution and the first-filtered medicine residue remaining in the metering filter. During the first filtration process of the metering filter, the following data can be recorded: the volume or weight of the concentrated medicine solution entering, the volume or weight of the first-filtered medicine solution, and the weight of the first-filtered medicine residue calculated. Step 9: Content determination: Take samples of the filtered liquid and determine its solid content and active ingredient content, and calculate the solid extraction rate and active ingredient transfer rate; Step 10, Secondary Feeding and Sieving: Take 1 / 4 of the weight of the total solids in the first filtration solution of maltodextrin, 1-4 parts by weight of sucralose, and 6 times the weight of the sum of the weights of maltodextrin and sucralose in room temperature water into the third extraction tank. After stirring and dissolving, add the first filtration solution into the third extraction tank, stir well, and filter through a 200-mesh inclined sieve to obtain the second filtration solution and the second filtration residue remaining in the third extraction tank. Step 11, spray drying: The secondary filtered drug solution is introduced into a spray dryer for spray drying. The inlet air temperature is 140-150℃, the outlet air temperature is 86-90℃, and the spray speed is 50-60 rpm. After spraying, a dry extract powder is obtained. The dry extract powder is weighed and the weight is recorded. Samples are taken to measure the content of active ingredients and the moisture content. The yield of the dry extract and the transfer rate of active ingredients are calculated. Step 12, Granulation and Sizing: Add the dry paste powder and maltodextrin (1 / 4 the weight of the dry paste powder) to a mixer and mix well to obtain a mixed dry material. Then, feed the mixed dry material into a dry granulator for dry granulation. The extrusion pressure is 28-30 MPa, the extrusion speed is 8 r / min, and the material transfer speed is 15 r / min to obtain sugar granules. Then, place the sugar granules into a granulator for granulation to obtain the finished Shuangyu sugar granules. Step 13, Packaging: The finished sugar granules are fed into the packaging machine and packaged into bags.

2. The preparation process of the double-corn sugar granules according to claim 1, characterized in that, The equipment used in steps one through eleven includes a single-effect concentrator (4), a metering filter (5), and a spray dryer (6) arranged in sequence. The single-effect concentrator (4) and the metering filter (5) are provided with an extraction support (1) on their sides. The extraction support (1) is provided with three equally spaced extraction tanks (3) and two equally spaced liquid pumps (7). The three extraction tanks (3) are respectively referred to as the first extraction tank, the second extraction tank, and the third extraction tank. The extraction support (1) is provided with three transfer pump stations (2) on its side. The transfer pump stations (2) are located below the extraction tanks (3). The first liquid pump (7) is connected to the second extraction tank and the single-effect concentrator (4) respectively. The second liquid pump (7) is connected to the third extraction tank and the spray dryer (6) respectively. The single-effect concentrator (4) and the metering filter (5) are connected by a pipe. The metering filter (5) and the third extraction tank are connected by a pipe.

3. The preparation process of the double-corn sugar granules according to claim 2, characterized in that, The upper end of the extraction bracket (1) is provided with three equally spaced clearance holes (9), and the extraction bracket (1) is provided with three sets of circumferentially distributed weighing sensors (10), each set of weighing sensors (10) has four sensors, and the upper end of the extraction bracket (1) is provided with a guardrail (8).

4. The preparation process of the double-corn sugar granules according to claim 3, characterized in that, The extraction tank (3) includes an extraction tank body (12). A stirring rack is rotatably installed inside the extraction tank body (12). A stirring motor is fixed at the upper end of the extraction tank body (12). The output shaft of the stirring motor is fixedly connected to the rotating shaft of the stirring rack. Several feeding cylinders (15) and liquid injection pipes are provided at the upper end of the extraction tank body (12). An insulation layer (11) is provided on the outside of the extraction tank body (12). Several circulation pipes (13) are provided on the outside of both the extraction tank body (12) and the insulation layer (11). Several circulation pipes (13) connected to the extraction tank body (12) penetrate the insulation layer (11). The insulation layer (11) is located outside the... Four circumferentially distributed mounting seats (14) are fixed on the upper side. The mounting seats (14) are fixed on the upper end of the corresponding weighing sensor (10). Two symmetrically arranged hinge seats (16) are fixed on the lower outer side of the insulation layer (11). A flip cover seat (26) is fixed on the lower end of the insulation layer (11). A bottom flip cover (22) is hinged on the flip cover seat (26). A symmetrically arranged base (21) is fixed on both sides of the bottom flip cover (22). A flip cover electric push rod (17) is hinged between the base (21) and the hinge seat (16) on the same side. A sealing ring and a locking ring (18) are rotatably provided on the lower end of the insulation layer (11). On the inner side of the locking ring (18), several circumferentially distributed locking grooves (19) are provided on the locking ring (18). Two symmetrically arranged rotating electric push rods (24) are provided at the bottom of the outer side of the insulation layer (11). The telescopic ends of the rotating electric push rods (24) are hinged to the locking ring (18). Both ends of the rotating shaft of the flip cover seat (26) and the bottom flip cover (22) are provided with liquid suction pipes (23). The liquid inlet end of the liquid suction pipe (23) is connected to the bottom of the bottom flip cover (22), and the liquid outlet end of the liquid suction pipe (23) is connected to the liquid suction pump (7). An inclined screen (28) is fixed at the upper end of the bottom flip cover (22). The upper end of the cover (22) is fixed with a baffle ring plate (20) with a notch on one side. The inclined screen (28) is located inside the baffle ring plate (20). The top side of the inclined screen (28) is fixed with a semi-circular spray ring (29). The inner side of the spray ring (29) is provided with several equally spaced nozzles. The nozzles are directly opposite the notch. The lower end of the spray ring (29) is provided with a high-pressure inlet pipe (25) connected to it. The high-pressure inlet pipe (25) extends through the bottom flip cover (22). The outside of the bottom flip cover (22) is provided with a ring of evenly distributed locking rods (27). The position and number of locking rods (27) correspond to the locking groove (19).

5. The preparation process of a double-corn sugar granule according to claim 4, characterized in that, The inclined screens (28) inside the second and third extraction tanks have apertures of 100 mesh and 200 mesh, respectively.

6. The preparation process of a double-corn sugar granule according to claim 5, characterized in that, The transfer pump station (2) includes a support receiving cylinder (30), a transfer pump (33) and a pump box (34). A connecting pipe (32) is connected between the inlet end of the support receiving cylinder (30) and the pump box (34). The support receiving cylinder (30) is located directly below the main body (12) of the extraction tank. The outlet end of the pump box (34) is connected to the inlet end of the transfer pump (33). The transfer pump (33) is connected to the feeding cylinder (15) at the corresponding position.

7. The preparation process of a double-corn sugar granule according to claim 6, characterized in that, The single-effect concentrator (4) includes a concentrator support (35), on which a heater (36), an evaporation chamber (37), a cooler (38) and a concentrator condenser (39) are connected in sequence. The heater (36) and the evaporation chamber (37) are both provided with heat insulation layers. A filter screen is provided at the connection between the evaporation chamber (37) and the cooler (38). A filter connector (40) is provided between the cooler (38) and the concentrator condenser (39).

8. The preparation process of a double-corn sugar granule according to claim 7, characterized in that, The metering filter (5) includes a filter frame (41), an electrical control box (42), a filter cartridge (43) and a filter pump (44) are provided on the filter frame (41). A metering valve is provided between the liquid inlet end of the filter pump (44) and the filter cartridge (43). The electrical control box (42) is electrically connected to the filter pump (44) and the metering valve respectively. The filter screen inside the filter cartridge (43) has a mesh size of 200 mesh.

9. The preparation process of a double-corn sugar granule according to claim 8, characterized in that, The spray dryer (6) includes a platform frame (46), an electric heating thermal oil furnace (52), a chiller box (55), an exhaust fan (56), a storage tank (57), and a collection tank (58). A ladder (45) is provided on the side of the platform frame (46). A spray drying cylinder (47), an expansion tank (50), a high-temperature high-efficiency filter (51), a steam blower (53), and a primary and secondary efficiency filter (54) are fixed on the platform frame (46). The air inlet of the steam blower (53) is connected to the primary and secondary efficiency filter (54). A steam heater is provided at the air outlet of the steam blower (53). The oil outlet of the steam heater and its corresponding circulation pipe (13) are connected to the oil return end of the electric heating thermal oil furnace (52) via an oil pipe. An oil pump is connected to the oil outlet of the electric heating thermal oil furnace (52). The oil pump is connected to the steam heater... The oil inlet and the corresponding circulation pipe (13) are connected by an oil pipe. Both oil pipes are connected to the expansion tank (50) by a pipe. The high temperature and high efficiency filter (51) is connected to the upper end of the steam heater. The high temperature and high efficiency filter (51) is connected to the spray drying cylinder (47) by a pipe. The collection tank (58) is connected to the lower end of the spray drying cylinder (47). The chiller box (55) is connected to the dryer condenser (48) by a pipe. The air inlet of the exhaust fan (56) is connected to the storage tank (57). The air outlet of the exhaust fan (56) is connected to the exhaust pipe (49). The dryer condenser (48) is connected to the storage tank (57). A spiral settling device is provided between the dryer condenser (48) and the spray drying cylinder (47). The lower discharge end of the spiral settling device is connected to the collection tank (58).

10. A finished sugar granule product prepared using the preparation process of double sugar granules as described in any one of 1-9.

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