Anti-aging and anti-fatigue traditional Chinese medicine formula and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses an anti-aging and anti-fatigue traditional Chinese medicine formula and a preparation method thereof. The traditional Chinese medicine formula comprises the following raw materials in parts by weight: 10-12 parts of ginseng, 10-15 parts of rhodiola rosea, 8-10 parts of dendrobium officinale, 5-6 parts of turmeric, 5-8 parts of cordyceps militaris, 8-10 parts of radix puerariae, 6-10 parts of schisandra chinensis, 1-3 parts of liquorice, 8-10 parts of lycium ruthenicum, 8-10 parts of cistanche, 10-12 parts of acanthopanax and 8-10 parts of phellinus igniarius. The adaptive capacity of an organism to an anoxic environment is improved, fatigue is effectively relieved, and various active ingredients contained in the health-care food contribute to delaying the senescence process.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine formula for anti-aging and anti-fatigue and its preparation method. Background Technology

[0002] In today's fast-paced life, people face pressure from work, life, and other aspects, making fatigue and aging issues increasingly prominent. Prolonged fatigue not only reduces work efficiency and affects quality of life, but can also trigger a series of health problems, such as weakened immunity and increased risk of cardiovascular disease. Furthermore, as people age, various physiological functions gradually decline, and the physical changes associated with aging, such as sagging skin, memory loss, and decreased bodily functions, also bring many challenges to people's lives.

[0003] Currently, there are various anti-fatigue and anti-aging products on the market. Common anti-fatigue products include functional beverages and health supplements. Functional beverages mainly stimulate the central nervous system by adding ingredients such as caffeine and taurine to achieve a refreshing effect; however, long-term, excessive consumption may lead to side effects such as palpitations and insomnia. Health supplements, on the other hand, are mostly based on single ingredients or simple formulas, with limited anti-fatigue effects, and some products may have inconsistent quality.

[0004] In the field of anti-aging, while chemically synthesized anti-aging drugs can improve aging symptoms to some extent, they are often accompanied by serious adverse reactions. Skincare products, on the other hand, primarily act on the skin's surface and cannot fundamentally address the aging problems within the body.

[0005] Traditional Chinese medicine (TCM), a treasure of my country's traditional medicine, possesses unique advantages in combating fatigue and aging. Most TCM herbs are natural plants, animals, or minerals, with relatively few side effects. Furthermore, their compound preparations can exert their effects through multiple targets and pathways, comprehensively regulating the body's physiological functions. However, existing TCM formulas for combating fatigue and aging often suffer from problems such as unreasonable formulations and outdated preparation processes, resulting in the inability of their effective components to fully exert their effects, making it difficult to guarantee the efficacy and quality of the products. Summary of the Invention

[0006] The purpose of this invention is to provide a traditional Chinese medicine formula for anti-aging and anti-fatigue and its preparation method, so as to solve the problems mentioned in the background art.

[0007] To achieve the above objectives, the present invention provides the following technical solution:

[0008] A traditional Chinese medicine formula for anti-aging and anti-fatigue includes the following ingredients in parts by weight: ginseng 10-12 parts, rhodiola rosea 10-15 parts, dendrobium officinale 8-10 parts, turmeric 5-6 parts, cordyceps militaris 5-8 parts, kudzu root 8-10 parts, schisandra chinensis 6-10 parts, licorice 1-3 parts, black goji berries 8-10 parts, cistanche deserticola 8-10 parts, eleutherococcus senticosus 10-12 parts, and mulberry fungus 8-10 parts.

[0009] The preferred ingredients are: 12 parts ginseng, 15 parts rhodiola rosea, 10 parts dendrobium officinale, 6 parts turmeric, 8 parts cordyceps militaris, 10 parts kudzu root, 6 parts schisandra chinensis, 3 parts licorice, 10 parts black goji berries, 10 parts cistanche deserticola, 10 parts eleutherococcus senticosus, and 8 parts mulberry fungus.

[0010] A method for preparing a traditional Chinese medicine formula for anti-aging and anti-fatigue includes the following steps:

[0011] S1. Preprocessing:

[0012] Rinse the ginseng, rhodiola rosea, dendrobium officinale, turmeric, cordyceps militaris, kudzu root, schisandra chinensis, licorice, black goji berries, cistanche deserticola, eleutherococcus senticosus, and mulberry fungus with clean water to remove dust, mud, and other impurities from the surface. Use a slicer to cut the washed herbs into thin slices with a thickness of 2-3 mm.

[0013] After washing and slicing the medicinal materials, place them in an environment with a room temperature of 20-25℃ and a relative humidity of 40%-60% to air dry naturally for 2-3 days;

[0014] S2, Crushing:

[0015] The dried medicinal materials are placed into an ultra-fine pulverizer in batches. The pulverizer speed is set to 20,000-30,000 rpm and the pulverizing time is 30-60 minutes until the medicinal materials are pulverized into ultra-fine powder with a particle size of 5-10 micrometers. After each batch is pulverized, it is screened through a 1000-1500 mesh sieve. Coarse powder that does not meet the particle size requirements is put back into the pulverizer for pulverization again.

[0016] S3, Mixing:

[0017] Accurately weigh each type of ultrafine powder using an electronic balance, and pour the weighed ultrafine powder into the three-dimensional mixer in sequence. Set the mixer's revolution speed to 10-15 rpm, its rotation speed to 20-30 rpm, and the mixing time to 40-60 minutes.

[0018] S4. Extraction:

[0019] Ginseng, Rhodiola rosea, Dendrobium officinale, turmeric, Cordyceps militaris, kudzu root, Schisandra chinensis, licorice, black goji berries, Cistanche deserticola, Acanthopanax senticosus, and Phellinus linteus are mixed with 70% ethanol at a mass-to-volume ratio of 1:8. The mixed ultrafine powder is added to the extraction tank, followed by the addition of 70% ethanol. The extraction temperature is controlled at 40-50℃. The extraction is repeated 2-3 times. After each extraction, the extract and residue are separated by a 200-300 mesh filter.

[0020] S5, Concentrated:

[0021] Combine the extracted liquids and transfer them to a vacuum concentrator. Turn on the vacuum pump to maintain the pressure inside the concentrator at -0.08 to -0.09 MPa. Control the concentration temperature at 40 to 50°C. Stop the concentration when the relative density reaches 1.2 to 1.3.

[0022] S6, Preparation:

[0023] Add purified water to the concentrate, add flavoring agents including cyclamate and sucrose, with cyclamate added at 0.05%-0.1% and sucrose added at 5%-10%, add preservatives including potassium sorbate, with an addition amount of 0.05%-0.1%, and stir thoroughly to ensure that all components are mixed evenly.

[0024] S7, Fine Filtration:

[0025] The prepared medicine solution is initially filtered through a plate and frame filter press to remove larger particles of impurities, and then finely filtered through a 0.45μm microporous membrane.

[0026] S8, Canned:

[0027] The filtered medicine is quantitatively filled into clean and sterilized oral liquid bottles using a filling machine. The filled oral liquid is then sterilized in 100°C steam for 30 minutes. After sterilization, the oral liquid is cooled to room temperature, labeled, and packaged as a finished product.

[0028] Compared with the prior art, the beneficial effects of the present invention are:

[0029] This invention's oral liquid contains 12 carefully selected medicinal herbs, including ginseng, rhodiola rosea, and dendrobium officinale. Ginseng greatly replenishes vital energy, significantly enhancing bodily vitality and boosting immunity; rhodiola rosea invigorates qi and blood circulation, improving the body's adaptability to hypoxic environments and effectively relieving fatigue; dendrobium officinale nourishes yin and clears heat, and its various active ingredients help slow down the aging process. The synergistic effect of these herbs in combating fatigue and aging is more comprehensive and significant than products with single ingredients or simple formulas.

[0030] Meanwhile, the preparation process of this invention adopts ultra-micro pulverization technology to pulverize the medicinal materials into ultra-micro powder with a particle size of 5-10 micrometers, thereby breaking the cell wall and greatly improving the dissolution rate of the effective ingredients. In addition, the medicinal materials used in the oral liquid of this invention are all natural ingredients. Compared with chemically synthesized anti-fatigue and anti-aging products, it avoids the side effects such as palpitations, insomnia, and increased cancer risk caused by chemical ingredients, providing consumers with a safe choice. Detailed Implementation

[0031] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0032] Example 1:

[0033] A traditional Chinese medicine formula for anti-aging and anti-fatigue:

[0034] Preparation method: Accurately weigh 1.2kg of ginseng, 1.5kg of rhodiola rosea, 1kg of dendrobium officinale, 0.6kg of turmeric, 0.8kg of cordyceps militaris, 1kg of kudzu root, 0.6kg of schisandra chinensis, 0.3kg of licorice, 1kg of black goji berries, 1kg of cistanche deserticola, 1kg of eleutherococcus senticosus, and 0.8kg of mulberry fungus.

[0035] Using a Shanghai-made XD-100 cleaning machine, place the above-mentioned medicinal materials into it and rinse for 5 minutes with a water flow rate of 50L / min to remove dust, mud and other impurities adhering to the surface.

[0036] Using a DW-200 slicer, cut hard medicinal materials such as ginseng, dendrobium officinale, and mulberry fungus into thin slices with a thickness of about 2-3 mm; for smaller block-shaped medicinal materials, cut them into small pieces with a side length of about 3-5 mm.

[0037] Spread all the medicinal materials evenly on a ventilated drying rack and air dry naturally for 2 days at a room temperature of 23℃ and a relative humidity of 50%.

[0038] Ultrafine grinding:

[0039] A JM-300 ultrafine pulverizer was used, with no more than 15 kg of dried medicinal materials placed inside each time. The rotation speed was set to 25,000 rpm, and the pulverizing time was 45 minutes, until the medicinal materials were pulverized into ultrafine powder with a particle size of about 5-10 micrometers.

[0040] After each batch is pulverized, the ultrafine powder is screened using a 1200-mesh sieve (model: SS-1200), and the coarse powder that does not meet the particle size requirements is put back into the pulverizer for pulverization again.

[0041] mix:

[0042] Using a Mettler Toledo AB204-S high-precision electronic balance, each type of ultrafine powder was accurately weighed according to the formula ratio, with the weighing error controlled within ±0.01g.

[0043] The weighed ultrafine powder was poured sequentially into a three-dimensional mixer of model SHR-500, with the mixer loading controlled at 70%. The revolution speed was set to 12 rpm, the rotation speed to 25 rpm, and the mixing time to 50 minutes to ensure that all components were fully and evenly mixed.

[0044] extract:

[0045] According to the ratio of medicinal materials to 70% ethanol solvent of 1:8 (mass-volume ratio), the uniformly mixed ultrafine powder is added into the YJ-1000 jacketed extraction tank, and then the corresponding amount of 70% ethanol is added.

[0046] Turn on the KQ-500DE ultrasonic generator and set the ultrasonic frequency to 50kHz. Simultaneously turn on the jacketed circulating water and control the extraction temperature at 45℃. Install a stirring paddle inside the extraction tank. The extraction time is 1.5 hours. Stir every 20 minutes during the extraction process at a speed of 60 rpm to ensure full contact between the medicinal materials and the solvent, allowing the active ingredients to dissolve completely.

[0047] The extraction was repeated three times. After each extraction, the extract and residue were separated by a GL-200 filter (250 mesh filter).

[0048] concentrate:

[0049] The extracts obtained from multiple extractions were combined and transferred to a vacuum concentrator of model SZ-500.

[0050] Turn on the vacuum pump (model: 2XZ-4) to maintain the pressure inside the concentrator at -0.085MPa, and at the same time turn on the heating device to control the concentration temperature at 45℃.

[0051] During the concentration process, continuously observe the relative density of the concentrate. When the relative density reaches 1.25 (measured at 60℃), stop the concentration.

[0052] Preparation:

[0053] Add an appropriate amount of purified water to the concentrate and dilute to a final volume of 100L.

[0054] Add 50-100g of cyclamate and 5-10kg of sucrose to improve the taste of the oral liquid.

[0055] Add 50-100g of potassium sorbate as a preservative to prevent microbial contamination and extend the shelf life of the oral liquid.

[0056] Use a JJ-500 mixer to thoroughly mix all ingredients.

[0057] Fine filtration:

[0058] The prepared medicine solution is initially filtered through a BBA-10 plate and frame filter press to remove larger particles of impurities.

[0059] Then, it is further filtered through a 0.45μm microporous membrane (model: MF-045) to remove tiny particles and microorganisms, ensuring the clarity and quality of the oral liquid.

[0060] Canning and sterilization:

[0061] The filtered medicine solution is quantitatively filled into clean and sterilized oral liquid bottles using a GF-100 filling machine. Each bottle is filled with 100ml, with an error controlled within ±1ml.

[0062] The high-pressure steam sterilizer, model YXQ-LS-50SII, is used to sterilize the filled oral liquid in 100℃ steam for 30 minutes to kill any microorganisms that may be present, ensuring the safety and stability of the product.

[0063] After sterilization, the oral liquid is cooled to room temperature, labeled, and packaged as a finished product.

[0064] Example 2:

[0065] 30L oral liquid finished product,

[0066] Weigh the medicinal materials: ginseng 0.6kg, rhodiola rosea 0.8kg, dendrobium officinale 0.6kg, turmeric 0.4kg, cordyceps militaris 0.5kg, kudzu root 0.7kg, schisandra chinensis 0.6kg, licorice 0.2kg, black goji berries 0.7kg, cistanche deserticola 0.7kg, eleutherococcus senticosus 0.8kg, and mulberry fungus 0.6kg.

[0067] A Shanghai-made SC-60 cleaning machine was used to rinse the medicinal materials for 8 minutes at a water flow rate of 25L / min to remove surface impurities.

[0068] Using a DP-120 slicer, hard medicinal materials are sliced ​​into 2-3 mm thin slices, and small pieces of medicinal materials are cut into 3-5 mm small pieces.

[0069] Spread the processed medicinal materials evenly on a ventilated drying rack and air dry naturally for 2 days at a room temperature of 21℃ and a relative humidity of 48%.

[0070] Ultrafine grinding:

[0071] Use an HF-150 ultrafine pulverizer, feeding no more than 8 kg of dried medicinal materials each time. Set the rotation speed to 23,000 rpm and the pulverizing time to 40 minutes, until the medicinal materials are pulverized into ultrafine powder with a particle size of 5-10 micrometers.

[0072] After each batch is crushed, it is screened with a 1300-mesh sieve (model: SW-1300), and coarse powder that does not meet the particle size requirements is crushed again.

[0073] mix:

[0074] Using a Sartorius BSA224S-CW high-precision electronic balance, each type of ultrafine powder was accurately weighed according to the formula, with the weighing error controlled within ±0.01g.

[0075] The weighed ultrafine powder was poured sequentially into a SH-200 three-dimensional mixer, with the loading volume controlled at 60%. The revolution speed was set to 12 revolutions per minute, the rotation speed to 22 revolutions per minute, and the mixing time to 45 minutes to ensure that the components were fully mixed.

[0076] extract:

[0077] According to the mass-volume ratio of medicinal materials to 70% ethanol solvent of 1:9, the mixed ultrafine powder was added to a jacketed extraction tank of model YT-350, and then the corresponding amount of 70% ethanol was added.

[0078] Turn on the KS-300 ultrasonic generator, set the ultrasonic frequency to 42kHz, and simultaneously turn on the jacket circulating water to control the extraction temperature at 43℃. Install the stirring paddle, extract for 1.5 hours, stirring every 15 minutes at a speed of 55 rpm to promote full contact between the medicinal materials and the solvent, ensuring complete dissolution of the active ingredients.

[0079] The extraction was repeated twice. After each extraction, the extract and residue were separated using a GL-120 filter (230 mesh filter) to ensure that the extraction conditions were consistent each time.

[0080] concentrate:

[0081] The extracts from multiple extractions were combined and transferred to a vacuum concentrator of model NZ-200.

[0082] Turn on the vacuum pump (model: 2XZ-1) to maintain the pressure inside the concentrator at -0.082MPa, and at the same time turn on the heating device to control the concentration temperature at 43℃.

[0083] Observe the relative density of the concentrate; stop concentration when it reaches 1.22 (measured at 60℃).

[0084] Preparation:

[0085] Add an appropriate amount of purified water to the concentrate and dilute to 30L.

[0086] Add 20-30g of cyclamate and 2-3kg of sucrose to improve the taste.

[0087] Add 20-30g of potassium sorbate as a preservative to prevent microbial contamination.

[0088] Use a JB-200 mixer to mix thoroughly.

[0089] Fine filtration:

[0090] The prepared medicine solution is initially filtered through a BBA-6 plate and frame filter press to remove large particulate impurities.

[0091] The oral liquid is then further filtered through a 0.45μm microporous membrane (model: MF-045-N) to ensure its clarity and quality.

[0092] Canning and sterilization:

[0093] Using a GF-40 filling machine, the filtered medicine is quantitatively filled into cleaned and sterilized oral liquid bottles, with each bottle containing 100ml and the error controlled within ±1ml.

[0094] The autoclave, model YXQ-LS-20SII, was used for sterilization in 100℃ steam for 25 minutes.

[0095] After sterilization, cool to room temperature, check the quality, remove unqualified products, affix labels, and package the finished products.

[0096] Experimental methods:

[0097] Animal grouping: Sixty mice were randomly divided into three groups of 20 each. The experimental group (administered traditional Chinese medicine oral liquid), the positive control group (administered ginsenoside Rg1 injection), and the negative control group (administered physiological saline).

[0098] Administration: Mice in the experimental group were administered the traditional Chinese medicine oral liquid by gavage daily at a dose of 0.2 ml / 10 g body weight; mice in the positive control group were administered ginsenoside Rg1 injection intraperitoneally daily at a dose of 5 mg / kg body weight; mice in the negative control group were administered physiological saline by gavage daily at a dose of 0.2 ml / 10 g body weight. Administration continued for 30 days.

[0099] Anti-fatigue effect test:

[0100] Swimming exhaustion test: On the 30th day after drug administration, mice were placed in a swimming tank with a water depth of 30 cm and a water temperature of 25 ± 1 ℃. The mice were loaded with lead weights of 5% of their body weight on their tails. The time from entering the water to exhaustion (sinking to the bottom and not being able to float to the surface for 10 seconds) was recorded as the swimming exhaustion time of the mice. The longer the swimming exhaustion time, the stronger the anti-fatigue ability.

[0101] Serum lactate and urea nitrogen levels were measured immediately after the exhaustive swimming test, by enucleation of the eyeballs and centrifugation at 3000 rpm for 10 minutes to separate the serum. The levels of lactate and urea nitrogen in the serum were measured using an ELISA reader according to the kit instructions. Increased serum lactate and urea nitrogen levels after exercise, coupled with the ability of the drug to reduce these levels, indicate an anti-fatigue effect.

[0102] The results are shown in Table 1:

[0103]

[0104]

[0105] In the exhaustive swimming experiment, the experimental group mice had a significantly longer exhaustion time than the negative control group (P<0.05), and also showed a slight advantage compared to the positive control group, indicating that the traditional Chinese medicine oral liquid can effectively improve the endurance of mice and enhance their anti-fatigue ability. Regarding serum lactate and urea nitrogen levels, the experimental group's levels were significantly lower than the negative control group (P<0.05), and similar to the positive control group. Increased serum lactate and urea nitrogen levels after exercise indicate fatigue accumulation; the lower levels in the experimental group suggest that the traditional Chinese medicine oral liquid can effectively reduce the accumulation of lactate and urea nitrogen in the body after exercise, alleviate fatigue, and has a significant anti-fatigue effect.

[0106] Anti-aging effect test:

[0107] Antioxidant index determination: On day 30 of drug administration, mice were sacrificed and liver tissue was collected. A 10% liver homogenate was prepared with physiological saline, centrifuged at 3000 rpm for 10 min, and the supernatant was collected. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), as well as the content of malondialdehyde (MDA), in the liver homogenate were measured using an enzyme-linked immunosorbent assay (ELISA) reader. Higher SOD and GSH-Px activities and lower MDA content indicated stronger antioxidant capacity and better anti-aging effects.

[0108] The experimental table is as follows:

[0109]

[0110] In the determination of antioxidant indicators, the SOD activity in the liver homogenate of mice in the experimental group was significantly higher than that in the negative control group (P<0.05), and also showed a certain degree of improvement compared to the positive control group, indicating that the traditional Chinese medicine oral liquid can effectively enhance the body's ability to scavenge superoxide anion free radicals. Regarding GSH-Px activity, the experimental group was also significantly higher than the negative control group (P<0.05), and superior to the positive control group, demonstrating the positive effect of the traditional Chinese medicine oral liquid in promoting glutathione participation in the antioxidant defense system. As for MDA content, the experimental group was significantly lower than the negative control group (P<0.05), and also lower than the positive control group, indicating that the traditional Chinese medicine oral liquid can effectively reduce lipid peroxidation and reduce oxidative damage in the body. In summary, the experimental group performed excellently in various antioxidant indicators, fully demonstrating that the administration of the traditional Chinese medicine oral liquid has significant antioxidant and anti-aging effects.

[0111] It should be understood that numerous specific implementation decisions can be made during the development of any practical implementation, such as in any engineering or design project. Such development efforts may be complex and time-consuming, but for those skilled in the art who benefit from this disclosure, the development effort will be a routine work of design, manufacturing, and production without requiring much experimentation.

[0112] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A traditional Chinese medicine formula for anti-aging and anti-fatigue, characterized in that, The ingredients include the following parts by weight: ginseng 10-12 parts, rhodiola rosea 10-15 parts, dendrobium officinale 8-10 parts, turmeric 5-6 parts, cordyceps militaris 5-8 parts, kudzu root 8-10 parts, schisandra chinensis 6-10 parts, licorice 1-3 parts, black goji berries 8-10 parts, cistanche deserticola 8-10 parts, eleutherococcus senticosus 10-12 parts, and mulberry fungus 8-10 parts.

2. The traditional Chinese medicine formula for anti-aging and anti-fatigue according to claim 1, characterized in that: Ginseng 12 parts, Rhodiola rosea 15 parts, Dendrobium officinale 10 parts, Curcuma longa 6 parts, Cordyceps militaris 8 parts, Pueraria lobata 10 parts, Schisandra chinensis 6 parts, Glycyrrhiza uralensis 3 parts, black goji berries 10 parts, Cistanche deserticola 10 parts, Acanthopanax senticosus 10 parts, Phellinus linteus 8 parts.

3. The method for preparing a traditional Chinese medicine formula for anti-aging and anti-fatigue according to claim 1, characterized in that: Includes the following steps: S1. Preprocessing: Rinse the ginseng, rhodiola rosea, dendrobium officinale, turmeric, cordyceps militaris, kudzu root, schisandra chinensis, licorice, black goji berries, cistanche deserticola, eleutherococcus senticosus, and mulberry fungus with clean water to remove dust, mud, and other impurities from the surface. Use a slicer to cut the washed herbs into thin slices with a thickness of 2-3 mm. After washing and slicing the medicinal materials, place them in an environment with a room temperature of 20-25℃ and a relative humidity of 40%-60% to air dry naturally for 2-3 days; S2, Crushing: The dried medicinal materials are placed into an ultra-fine pulverizer in batches. The pulverizer speed is set to 20,000-30,000 rpm and the pulverizing time is 30-60 minutes until the medicinal materials are pulverized into ultra-fine powder with a particle size of 5-10 micrometers. After each batch is pulverized, it is screened through a 1000-1500 mesh sieve. Coarse powder that does not meet the particle size requirements is put back into the pulverizer for pulverization again. S3, Mixing: Accurately weigh each type of ultrafine powder using an electronic balance, and pour the weighed ultrafine powder into the three-dimensional mixer in sequence. Set the mixer's revolution speed to 10-15 rpm, its rotation speed to 20-30 rpm, and the mixing time to 40-60 minutes. S4. Extraction: Ginseng, Rhodiola rosea, Dendrobium officinale, turmeric, Cordyceps militaris, kudzu root, Schisandra chinensis, licorice, black goji berries, Cistanche deserticola, Acanthopanax senticosus, and Phellinus linteus are mixed with 70% ethanol at a mass-to-volume ratio of 1:

8. The mixed ultrafine powder is added to the extraction tank, followed by the addition of 70% ethanol. The extraction temperature is controlled at 40-50℃. The extraction is repeated 2-3 times. After each extraction, the extract and residue are separated by a 200-300 mesh filter. S5, Concentrated: Combine the extracted liquids and transfer them to a vacuum concentrator. Turn on the vacuum pump to maintain the pressure inside the concentrator at -0.08 to -0.09 MPa. Control the concentration temperature at 40 to 50°C. Stop the concentration when the relative density reaches 1.2 to 1.

3. S6, Preparation: Add purified water to the concentrate, add flavoring agents including cyclamate and sucrose, with cyclamate added at 0.05%-0.1% and sucrose added at 5%-10%, add preservatives including potassium sorbate, with an addition amount of 0.05%-0.1%, and stir thoroughly to ensure that all components are mixed evenly. S7, Fine Filtration: The prepared medicine solution is initially filtered through a plate and frame filter press to remove larger particles of impurities, and then finely filtered through a 0.45μm microporous membrane. S8, Canned: The filtered medicine is quantitatively filled into clean and sterilized oral liquid bottles using a filling machine. The filled oral liquid is then sterilized in 100°C steam for 30 minutes. After sterilization, the oral liquid is cooled to room temperature, labeled, and packaged as a finished product.

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