Collagen maintenance liquid dressing with anti-aging function as well as preparation method and application of collagen maintenance liquid dressing

Abstract

The invention discloses a collagen maintenance liquid dressing with an anti-aging function as well as a preparation method and application of the collagen maintenance liquid dressing, and belongs to the technical field of cosmetics. Comprising the following components in parts by volume: 40-60 parts of distilled water, 20-30 parts of skin care product base oil or olive oil, 10-15 parts of recombinant collagen III, 3-8 parts of a pH regulator, 1-5 parts of an antioxidant and 0.5-2 parts of a plant preservative, wherein the pH regulator is a combination of lactic acid and tartaric acid, and the tartaric acid is selected according to the difference of skin types: malic acid for dry skin, citric acid for oily skin and a malic acid and citric acid compound for neutral or mixed skin. The invention aims to realize full dissolution and effective embedding of the components through batch charging and differential process parameters, and improve the stability and efficacy of the product. A nanoscale crystal structure is constructed, and the permeability and the slow-release effect of active ingredients are enhanced. Special maintenance liquid for different skin types is developed, and functional indexes such as moisturizing, water locking and antioxidation are optimized.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a collagen maintenance liquid dressing with anti-aging function, its preparation method, and its application. Background Technology

[0002] Currently, the formulas for skincare products on the market typically consist of: a base serum (deionized water / plant oils) + functional ingredients (such as collagen) + surfactants + preservatives + antioxidants. The production process is simple, mainly involving raw material dissolution → homogenization → packaging, using homogenizing tanks and packaging equipment.

[0003] Existing technological shortcomings: The feeding process is too simple: it is impossible to accurately control the particle size and component distribution of the product, resulting in uneven release of effective ingredients.

[0004] The process steps are crude: there is no clear distinction between the dissolution and homogenization processes, the product texture cannot be optimized, and it is difficult to meet functional requirements (such as nanoscale crystal structures).

[0005] Insufficient adaptability: The formulas and processes are not designed to be differentiated for different skin types (dry, oily, normal, combination, sensitive), resulting in limited effectiveness of general-purpose products.

[0006] Therefore, in response to the above-mentioned technical problems, it is necessary to provide a collagen maintenance dressing with anti-aging function, its preparation method, and its application.

[0007] The information disclosed in this background section is intended only to enhance the understanding of the overall background of the invention and should not be construed as an admission or in any way implying that the information constitutes prior art known to those skilled in the art. Summary of the Invention

[0008] The purpose of this invention is to provide a collagen maintenance liquid dressing with anti-aging function, its preparation method and application, which can solve the above-mentioned problems.

[0009] To achieve the above objectives, a specific embodiment of the present invention provides the following technical solution: Collagen maintenance liquid dressing with anti-aging function comprises the following components by volume: 40-60 parts distilled water, 20-30 parts skincare base oil or olive oil, 10-15 parts recombinant collagen type III, 3-8 parts pH adjuster, 1-5 parts antioxidant, and 0.5-2 parts plant preservative; The pH adjuster is a combination of lactic acid and fruit acid, and the fruit acid is selected differently according to skin type: malic acid for dry skin, citric acid for oily skin, and a complex of malic acid and citric acid for normal or combination skin. The dressing has a nanoscale crystal structure with an average particle size ≤100nm and a total bacterial count ≤100CFU / g.

[0010] In one or more embodiments of the present invention, 2-5 parts of a compound amino acid are added for sensitive skin, wherein the compound amino acid comprises arginine, serine and glycine in a mass ratio of 1:1.5:0.8.

[0011] In one or more embodiments of the present invention, the antioxidant is vitamin C or a derivative thereof, and the plant preservative is grapefruit peel extract.

[0012] In one or more embodiments of the present invention, a collagen maintenance solution dressing specifically for dry skin is provided, said maintenance solution dressing being made of the following components in parts by volume: Malic acid 0.5 parts, complex amino acids 0.3 parts, recombinant collagen type III 1.2 parts, distilled water 4 parts, olive oil 2 parts, vitamin C 0.2 parts, grapefruit peel extract 0.1 parts.

[0013] In one or more embodiments of the present invention, a collagen maintenance solution dressing specifically for oily skin is characterized in that the maintenance solution dressing is made of the following components in parts by volume: Citric acid 0.6 parts, plant fungicide 0.1 parts, recombinant collagen type III 1.0 parts, distilled water 5 parts, base oil 1.8 parts, VC derivative 0.3 parts.

[0014] In one or more embodiments of the present invention, a method for preparing a collagen maintenance liquid dressing with anti-aging function includes the following steps: S1. Raw material premixing: Mix distilled water, base oil / olive oil, and recombinant collagen type III in proportion, stir at a constant temperature of 40-50℃ and 500-800rpm for 20-30 minutes, and then let it stand at 30-40℃ for 15-20 minutes to settle. S2. Add functional ingredients in stages: Add pH adjuster, antioxidant, plant preservative and compound amino acid in sequence. After each ingredient is added, stir for 10-15 minutes at 35-45℃ and 600-1000rpm, and let it stand at 30-40℃ for 10-15 minutes to settle. S3. Multiple premixing and sedimentation: Repeat the premixing operation 8 times. The premixing parameters are: temperature gradient 40-60℃, time gradient 10-20 minutes, and speed gradient 800-1200 rpm. After each round of premixing, perform 10 sedimentation operations. The sedimentation parameters are: temperature 25-35℃ and time 10-30 minutes. S4. Vacuum homogenization: Homogenize three times under a pressure of 10-20MPa, each time for 5-10 minutes, to make the particle size ≤100nm; S5. Filling Classification: Adjust the formula ratio according to skin type and fill aseptic (colony ≤10CFU / g) or non-sterile (colony ≤100CFU / g).

[0015] In one or more embodiments of the present invention, in step S3, the premixing temperature gradient is 45℃→50℃→55℃→60℃ for two cycles, and the precipitation temperature gradient is 30℃→25℃→35℃ for three cycles.

[0016] In one or more embodiments of the present invention, in step S4, the homogeneous pressure gradient is 10MPa→15MPa→20MPa, with each pressure increase being 5MPa.

[0017] In one or more embodiments of the present invention, a nanoscale crystal structure is constructed by staged addition, gradient temperature premixing and multi-stage precipitation process to achieve an active ingredient encapsulation rate of ≥95% and a crystal particle size of ≤100nm.

[0018] In one or more embodiments of the present invention, the application of a collagen maintenance liquid dressing with anti-aging function in the preparation of skin anti-aging care products, wherein the care products are used to improve the skin moisturizing index to ≥6, the water retention index to ≥7, and reduce the adverse reaction rate of sensitive skin to ≥50%.

[0019] Compared with the prior art, the present invention has the following beneficial effects: 1) Refined process: Staged stirring and sedimentation combined with multiple premixing significantly improves the solubility and encapsulation rate of components; 2) Functional optimization: The nano-scale crystal structure enables a moisturizing index ≥6 and a water-locking index ≥7, while also enhancing the antioxidant index; 3) Enhanced adaptability: Specialized formulas are designed for different skin types, improving suitability for sensitive skin; 4) Energy-saving and efficient: By controlling the temperature gradient, energy consumption is reduced and the production cycle is shortened. Attached Figure Description

[0020] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0021] Figure 1 This is a flowchart illustrating a method for preparing an anti-aging collagen maintenance liquid dressing according to an embodiment of the present invention. Detailed Implementation

[0022] To enable those skilled in the art to better understand the technical solutions of this invention, the technical solutions of the embodiments of this invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this invention, and not all embodiments. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of this invention.

[0023] This invention aims to improve product stability and efficacy by achieving full dissolution and effective encapsulation of ingredients through batch feeding and differentiated process parameters. It also involves constructing a nanoscale crystal structure to enhance the permeability and sustained-release effect of active ingredients. Furthermore, it develops specialized maintenance solutions for different skin types, optimizing functional indicators such as moisturizing, water-locking, and antioxidant properties.

[0024] Example 1: Collagen maintenance liquid dressing specifically for dry skin (I) Formula composition (based on a total volume of 100L)

[0025] (II) Preparation process S1. Raw material premixing: Distilled water, olive oil, and recombinant collagen type III are injected into the reaction vessel; Stir at 45℃ (1000 rpm, 25 minutes) → let stand at 30℃ for 18 minutes to settle.

[0026] S2. Add functional ingredients in stages: Malic acid, complex amino acids, vitamin C, and grapefruit peel extract are added in sequence; After each addition of an ingredient: stir at 40°C (800 rpm, 12 minutes) → settle at 35°C (12 minutes).

[0027] S3, Multiple premixing and sedimentation: Premixed cycle 8 times: temperature gradient 45℃→50℃→55℃→60℃→45℃... (5℃ increase per stage), time gradient 12→15→18→20 minutes, speed gradient 1000→1200 rpm; Precipitation cycled 10 times: constant temperature 30℃, 15 minutes each time.

[0028] S4. Vacuum homogenization: Homogenization pressure gradient 10MPa→15MPa→20MPa (increasing by 5MPa each time), 8 minutes each time, 3 cycles.

[0029] S5. Filling: Aseptic filling (colony control ≤10CFU / g).

[0030] (III) Performance Testing

[0031] Testing standards: The moisturizing / water-locking index is based on the "QB / T4256-2011 Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics"; the encapsulation rate is calculated by determining the free collagen content using HPLC.

[0032] Example 2: Collagen maintenance liquid dressing specifically for oily skin (I) Formula composition (based on a total volume of 100L)

[0033] (II) Preparation process S1. Raw material premixing: Distilled water, skin care base oil, and recombinant collagen type III are injected into the reaction vessel; Stir at 50℃ (1200 rpm, 20 minutes) → allow to settle at 25℃ (15 minutes).

[0034] S2. Add functional ingredients in stages: First stage: Add citric acid, then stir at 45℃ and 1000rpm for 15 minutes → let stand at 30℃ for 12 minutes to precipitate; Second stage: Add tea tree oil extract, stir at 40℃ and 900rpm for 12 minutes → let stand at 28℃ for 10 minutes to settle; Third stage: Add VC ethyl ether, stir at 35℃ and 800rpm for 10 minutes → let stand at 25℃ for 10 minutes to precipitate.

[0035] S3, Multiple premixing and sedimentation: Premixed cycle 8 times: Temperature gradient: 50℃ constant temperature (maintain the same temperature each time, without gradient change); Time gradient: 15 minutes each time; Speed ​​gradient: 1200 rpm constant; Precipitation cycled 10 times: constant temperature 25℃, 15 minutes each time.

[0036] S4. Vacuum homogenization: Homogenize under a constant pressure of 20 MPa (without gradient change); each homogenization session lasts 10 minutes, and the cycle is repeated 3 times.

[0037] Filling: Aseptic filling (colony control ≤10 CFU / g).

[0038] (III) Performance Testing

[0039] Testing standards: Particle size detection: Dynamic light scattering (DLS); Encapsulation efficiency: The content of free collagen was determined by HPLC. Antioxidant Index: ORAC method (Oxygen free radical absorption capacity); Nutrient penetration: Franz diffusion cell method (ex vivo skin model).

[0040] Key process comparison (Example 2 vs. Example 1)

[0041] Compared to Example 1, Example 2 has the following advantages: 1. Oil control advantages: Precipitation at 25℃ causes oil molecules to arrange themselves in an orderly manner, increasing the adsorption capacity to 92% (compared to 70% with traditional methods). The first step involves adding citric acid to immediately adjust the pH to 4.5, thereby inhibiting sebaceous gland activity.

[0042] 2. Activity protection: Premixing at a constant temperature of 50℃ avoids thermal decomposition of VC ethyl ether; Adding it in stages prevents citric acid from directly contacting collagen and causing denaturation.

[0043] Instructions for using this anti-aging collagen maintenance liquid dressing: After cleansing your face at night, take 3mL of the dressing and apply it evenly, massaging until absorbed. Use 3-5 times a week. Nanocrystal sustained-release effect: Active ingredients are continuously released for 6-8 hours, covering the golden period of skin metabolism.

[0044] The advantages of this invention are: 1. Refined process: Staged stirring and sedimentation combined with multiple premixing significantly improves the solubility and encapsulation rate of components (experimental data: encapsulation rate ≥95%, while the existing technology is 80%).

[0045] 2. Functional optimization: The nano-scale crystal structure improves the moisturizing index to ≥6, the water-locking index to ≥7 (compared to 4 and 5 in traditional processes), and increases the antioxidant index by 20%.

[0046] 3. Enhanced adaptability: Special formulas are designed for different skin types, increasing suitability for sensitive skin by 50% (clinical test data).

[0047] 4. Energy-saving and efficient: Through temperature gradient control, energy consumption is reduced by 30% and the production cycle is shortened by 25%.

[0048] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0049] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A collagen-maintaining liquid dressing with anti-aging function, characterized in that, The components include the following volume parts: 40-60 parts distilled water, 20-30 parts skincare base oil or olive oil, 10-15 parts recombinant collagen type III, 3-8 parts pH adjuster, 1-5 parts antioxidant, and 0.5-2 parts plant preservative; The pH adjuster is a combination of lactic acid and fruit acid, and the fruit acid is selected differently according to skin type: malic acid for dry skin, citric acid for oily skin, and a complex of malic acid and citric acid for normal or combination skin. The dressing has a nanoscale crystal structure with an average particle size ≤100nm and a total bacterial count ≤100CFU / g.

2. The collagen maintenance liquid dressing with anti-aging function according to claim 1, characterized in that, For sensitive skin, add 2-5 parts of compound amino acids, which include arginine, serine and glycine in a mass ratio of 1:1.5:0.

8.

3. The collagen maintenance liquid dressing with anti-aging function according to claim 2, characterized in that, The antioxidant is vitamin C or a derivative thereof, and the plant preservative is grapefruit peel extract.

4. The collagen maintenance liquid dressing with anti-aging function according to any one of claims 1-3, specifically for dry skin, characterized in that, The maintenance fluid dressing is made from the following components in parts by volume: Malic acid 0.5 parts, complex amino acids 0.3 parts, recombinant collagen type III 1.2 parts, distilled water 4 parts, olive oil 2 parts, vitamin C 0.2 parts, grapefruit peel extract 0.1 parts.

5. The collagen maintenance liquid dressing with anti-aging function according to any one of claims 1-3, specifically for oily skin, characterized in that, The maintenance fluid dressing is made from the following components in parts by volume: Citric acid 0.6 parts, plant fungicide 0.1 parts, recombinant collagen type III 1.0 parts, distilled water 5 parts, base oil 1.8 parts, VC derivative 0.3 parts.

6. A method for preparing a collagen maintenance liquid dressing with anti-aging function as described in any one of claims 1-3, characterized in that, Includes the following steps: S1. Raw material premixing: Mix distilled water, base oil / olive oil, and recombinant collagen type III in proportion, stir at a constant temperature of 40-50℃ and 500-800rpm for 20-30 minutes, and then let it stand at 30-40℃ for 15-20 minutes to settle. S2. Add functional ingredients in stages: Add pH adjuster, antioxidant, plant preservative and compound amino acid in sequence. After each ingredient is added, stir for 10-15 minutes at 35-45℃ and 600-1000rpm, and let it stand at 30-40℃ for 10-15 minutes to settle. S3. Multiple premixing and sedimentation: Repeat the premixing operation 8 times. The premixing parameters are: temperature gradient 40-60℃, time gradient 10-20 minutes, and speed gradient 800-1200 rpm. After each round of premixing, perform 10 sedimentation operations. The sedimentation parameters are: temperature 25-35℃ and time 10-30 minutes. S4. Vacuum homogenization: Homogenize three times under a pressure of 10-20MPa, each time for 5-10 minutes, to make the particle size ≤100nm; S5. Filling Classification: Adjust the formula ratio according to skin type and fill aseptic (colony ≤10CFU / g) or non-sterile (colony ≤100CFU / g).

7. The method for preparing a collagen maintenance liquid dressing with anti-aging function according to claim 6, characterized in that, In S3, the premixing temperature gradient is 45℃→50℃→55℃→60℃ for two cycles, and the precipitation temperature gradient is 30℃→25℃→35℃ for three cycles.

8. The method for preparing a collagen maintenance liquid dressing with anti-aging function according to claim 6, characterized in that, In S4, the homogeneous pressure gradient is 10MPa→15MPa→20MPa, with each pressure increase being 5MPa.

9. A method for preparing a collagen maintenance liquid dressing with anti-aging function according to any one of claims 6-8, characterized in that, The nanoscale crystal structure is constructed by the staged addition, gradient temperature premixing and multi-stage precipitation process described in claims 6-8, achieving an active ingredient encapsulation rate of ≥95% and a crystal particle size of ≤100nm.

10. The application of the collagen maintenance liquid dressing with anti-aging function according to any one of claims 1-3 in the preparation of skin anti-aging care products, characterized in that, The stated care products are designed to improve the skin's hydration index to ≥6, its moisture retention index to ≥7, and reduce the adverse reaction rate of sensitive skin by ≥50%.

Images