Composition containing white poria extract, preparation method and application

Abstract

The invention relates to the technical field of traditional Chinese medicine extracts, and discloses a composition containing a white poria extract, a preparation method and application, the composition comprises the following components by weight: 4-8 parts of a white poria extract, 2-5 parts of ceramide, 1.5-3.5 parts of an artemisia apiacea extract, 1-3 parts of a green tea extract, 0.5-2 parts of a rhodiola rosea extract, 3-7 parts of glycerin, and 6-10 parts of a phospholipid solution. According to the whitening mask, the transdermal amount of the white poria extract is increased by 3 times through the lipidosome and the small-particle-size design, and the whitening mask effectively whitens the skin by combining the synergistic effect of ceramide and lipidosome. Meanwhile, the green tea extract and the artemisia apiacea extract are combined for use to effectively sterilize and resist inflammation. By accurately controlling the formula proportion and process parameters, the composition realizes synergistic interaction in the aspects of moisturizing, anti-inflammation, whitening and the like, and meets the requirements of safety and stability at the same time.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine extract technology, specifically to a composition containing Poria cocos extract, its preparation method, and its application. Background Technology

[0002] Poria cocos extract is a mixture of active ingredients extracted from the traditional Chinese medicinal herb Poria cocos (the white part inside the dried sclerotium of Poria cocos). It mainly contains polysaccharides, triterpenoids (such as pachymic acid), sterols, fatty acids, and trace elements. Currently, taking advantage of its anti-inflammatory and moisturizing properties, Poria cocos extract is added to face masks and lotions.

[0003] For example, an existing Chinese patent (CN108578282A) discloses a method for preparing a whitening and spot-fading emulsion containing Poria cocos extract, including: preparing Poria cocos extract, preparing licorice extract, preparing maca extract, extracting buckwheat starch, preparing granular cold water-soluble buckwheat starch, and preparing the emulsion. This invention uses plant extracts as active ingredients. Poria cocos extract is a high-performance natural whitening additive with whitening and spot-fading effects. Licorice's main active ingredients are glycyrrhizic acid and flavonoids, which have excellent whitening, spot-fading, and anti-aging effects. Maca contains polysaccharides, hyaluronic acid, dextran, biosaccharide gum, etc., which have good moisturizing effects, while maca is rich in various amino acids, possessing excellent whitening effects.

[0004] Existing emulsions and other products containing Poria cocos extract often involve the direct addition of plant extracts, which have large molecular weights and suffer from low transdermal penetration and easy degradation of active ingredients. Summary of the Invention

[0005] The purpose of this invention is to provide a composition containing Poria cocos extract, a preparation method thereof, and its application, in order to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a composition containing Poria cocos extract, comprising the following components in parts by weight: 4-8 parts Poria cocos extract, 2-5 parts ceramide, 1.5-3.5 parts Artemisia annua extract, 1-3 parts green tea extract, 0.5-2 parts Rhodiola rosea extract, 3-7 parts glycerin, 6-10 parts phospholipid solution, 0.5-1.2 parts sodium hyaluronate, 0.8-1.5 parts natural preservative, and the balance being deionized water.

[0007] Preferably, the components include the following parts by weight: 4 parts Poria cocos extract, 2 parts ceramide, 1.5 parts Artemisia annua extract, 1 part green tea extract, 0.5 parts Rhodiola rosea extract, 3 parts glycerin, 6 parts phospholipid solution, 0.5 parts sodium hyaluronate, 0.8 parts natural preservative, and the balance being deionized water.

[0008] Preferably, the components include the following parts by weight: 6 parts Poria cocos extract, 3 parts ceramide, 2.5 parts Artemisia annua extract, 2 parts green tea extract, 1.5 parts Rhodiola rosea extract, 5 parts glycerin, 8 parts phospholipid solution, 0.8 parts sodium hyaluronate, 1.2 parts natural preservative, and the balance being deionized water.

[0009] Preferably, the components include the following parts by weight: 8 parts of Poria cocos extract, 5 parts of ceramide, 3.5 parts of Artemisia annua extract, 3 parts of green tea extract, 2 parts of Rhodiola rosea extract, 7 parts of glycerin, 10 parts of phospholipid solution, 1.2 parts of sodium hyaluronate, 1.5 parts of natural preservative, and the balance being deionized water.

[0010] Preferably, the natural preservative is 1,2-hexanediol and p-hydroxyacetophenone, wherein the weight ratio of 1,2-hexanediol to p-hydroxyacetophenone is 2:1.

[0011] A method for preparing a composition containing Poria cocos extract includes the following steps: Step 1: Dissolve the extract of Poria cocos in a phospholipid solution and prepare a liposome solution with a particle size of less than 80 nm using a high-pressure homogenizer; Step 2: Rotary evaporate the liposome solution from Step 1 to remove ethanol and obtain an aqueous dispersion; Step 3: Heat the ceramide until it melts, then slowly add it to the aqueous dispersion and stir until homogeneous; Step 4: Add glycerin and sodium hyaluronate to deionized water in sequence, and stir at 50-60 degrees Celsius until completely dissolved; Step 5: After cooling the solution from Step 4 to below 40°C, add Artemisia annua extract, green tea extract, and Rhodiola rosea extract, and stir until homogeneous; Step 6: Slowly add the aqueous dispersion obtained in Step 3 to the solution obtained in Step 5, and stir homogenize to obtain the pre-emulsion; Step 7: Ultrasonic stirring of the colostrum to further reduce the particle size to 50-70 nm; Step 8: After the colostrum from Step 7 has cooled to 30°C, add 1,2-hexanediol and p-hydroxyacetophenone, and stir until homogeneous; Step 9: After sterilization by filtration through a microporous membrane, the finished emulsion is obtained.

[0012] Preferably, the phospholipid solution is a mixed solution obtained by adding an appropriate amount of ethanol to hydrogenated lecithin and cholesterol at a molar ratio of 1:1.

[0013] Preferably, during rotary evaporation in step two, the temperature is controlled at 35-40℃, the vacuum degree is greater than or equal to 0.09MPa, and the residual ethanol is detected by gas chromatography after evaporation to ensure that the ethanol content is less than 0.5%.

[0014] Preferably, in step five, when adding Rhodiola rosea extract, the pH value of the solution is between 5 and 7.

[0015] Application of a composition containing Poria cocos extract in skin care products.

[0016] Compared with the prior art, the beneficial effects of the present invention are: This invention utilizes liposomes and small particle size design to increase the transdermal absorption of Poria cocos extract by 3 times. Combined with the synergistic effect of ceramides and liposomes, it effectively whitens the skin. Simultaneously, the combined use of green tea extract and Artemisia annua extract provides effective antibacterial and anti-inflammatory effects. Through precise control of the formulation ratios and process parameters, this composition achieves synergistic effects in moisturizing, anti-inflammatory, and whitening, while meeting safety and stability requirements.

[0017] The parts of the device not covered herein are the same as or can be implemented using existing technologies. Attached Figure Description

[0018] Figure 1 This is a flowchart illustrating a method for preparing a composition containing Poria cocos extract according to the present invention; Detailed Implementation

[0019] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0020] Example 1: This invention provides a technical solution: a composition containing Poria cocos extract, comprising the following components in parts by weight: 4-8 parts Poria cocos extract, 2-5 parts ceramide, 1.5-3.5 parts Artemisia annua extract, 1-3 parts green tea extract, 0.5-2 parts Rhodiola rosea extract, 3-7 parts glycerin, 6-10 parts phospholipid solution, 0.5-1.2 parts sodium hyaluronate, 0.8-1.5 parts natural preservative, and the balance being deionized water.

[0021] The core active ingredients in Poria cocos extract include Poria cocos polysaccharide and Poria cocos acid. The content of Poria cocos acid is ≥10% and the content of Poria cocos polysaccharide is ≥25%. Among them, the main functions of Poria cocos polysaccharide are anti-oxidation and moisturizing, while the main functions of Poria cocos acid are anti-inflammatory and whitening.

[0022] Poria cocos polysaccharides reduce transepidermal water loss by forming a hydration film; experiments show that a 0.5% concentration can reduce TEWL by 20%. Poria cocos acid inhibits tyrosinase activity and melanin production. 4-8 parts ensure sufficient moisturizing to enhance whitening; excessive amounts may affect liposome encapsulation efficiency.

[0023] Ceramides are used to repair the skin barrier and reduce moisture loss. Replenishing ceramides lost in the stratum corneum enhances the lamellar lipid structure; studies show that a 2% concentration can increase barrier repair speed by 30%. Two parts provide basic repair, while five parts are suitable for dry / sensitive skin; melting temperature should be controlled to avoid crystallization.

[0024] Glycerin is used as a humectant moisturizer to provide instant hydration. The three hydroxyl groups in the glycerin molecule form hydrogen bonds with water molecules, allowing it to absorb up to twice its own weight in water even in low humidity conditions. Three parts balance moisturizing and skin feel, while seven parts may result in a sticky feeling, which is synergistically regulated by sodium hyaluronate.

[0025] Artemisinin in Artemisia annua extract contains ≥5% for anti-inflammatory and antibacterial effects. Artemisinin reduces the release of inflammatory factors; a 1% concentration can reduce the erythema index by 25%. 1.5 parts provide basic anti-inflammatory effects, while 3.5 parts are suitable for acne / eczema-prone skin. Low-temperature addition is necessary to prevent artemisinin degradation.

[0026] Green tea extract contains ≥40% tea polyphenols, which are used for anti-oxidation and photoprotection. Tea polyphenols scavenge free radicals and reduce UV-induced DNA damage. One part provides daily antioxidant protection, while three parts enhance photoprotection. pH control is necessary to prevent the oxidation of tea polyphenols under alkaline conditions.

[0027] Rhodiola rosea extract containing ≥3% rhodioloside is used for anti-fatigue and skin brightening. Rhodioloside promotes cellular energy metabolism; studies show that a 0.5% concentration can improve skin radiance by 15%. 0.5 parts is for basic brightening, and 2 parts is suitable for dull skin; pH monitoring is necessary to prevent glycoside hydrolysis.

[0028] Sodium hyaluronate is used for deep moisturizing and lubrication. Large molecules of sodium hyaluronate form a film on the skin surface, while smaller molecules penetrate the dermis to absorb water and swell. 0.5 parts provide basic moisturizing, while 1.2 parts enhance lubrication. Dissolve in stages to prevent clumping.

[0029] Phospholipid solution is used to encapsulate Poria cocos extract to form liposomes, improving transdermal absorption. A stable bilayer is constructed by a 1:1 molar ratio of hydrogenated lecithin to cholesterol, achieving an encapsulation rate of up to 85%. Six parts are sufficient for basic encapsulation, while ten parts are suitable for high-concentration extracts, requiring control of ethanol residue.

[0030] A natural preservative mixture of 1,2-hexanediol and p-hydroxyacetophenone in a 2:1 ratio is used for antibacterial purposes and is non-irritating. 1,2-hexanediol disrupts bacterial cell membranes, while p-hydroxyacetophenone inhibits enzyme activity; the combination increases preservative efficiency by 40%. 0.8 parts provide basic preservative protection, while 1.5 parts are suitable for high-temperature environments and require pre-dissolution to prevent precipitation.

[0031] Deionized water is used as a solvent to adjust viscosity. The conductivity of deionized water is <1 μS / cm to prevent metal ions from catalyzing the oxidation of components. The total weight is dynamically adjusted based on the total amount of other components to ensure a total weight of 100.

[0032] Example 2: The present invention provides a technical solution: a composition containing Poria cocos extract, comprising the following components in parts by weight: 4 parts Poria cocos extract, 2 parts ceramide, 1.5 parts Artemisia annua extract, 1 part green tea extract, 0.5 parts Rhodiola rosea extract, 3 parts glycerin, 6 parts phospholipid solution, 0.5 parts sodium hyaluronate, 0.8 parts natural preservative, and the balance being deionized water.

[0033] The core active ingredients in Poria cocos extract include Poria cocos polysaccharide and Poria cocos acid. The content of Poria cocos acid is ≥10% and the content of Poria cocos polysaccharide is ≥25%. Among them, the main functions of Poria cocos polysaccharide are anti-oxidation and moisturizing, while the main functions of Poria cocos acid are anti-inflammatory and whitening.

[0034] Poria cocos polysaccharides reduce transepidermal water loss by forming a hydration film; experiments show that a 0.5% concentration can reduce TEWL by 20%. Poria cocos acid inhibits tyrosinase activity and melanin production. 4-8 parts ensure sufficient moisturizing to enhance whitening; excessive amounts may affect liposome encapsulation efficiency.

[0035] Ceramides are used to repair the skin barrier and reduce moisture loss. Replenishing ceramides lost in the stratum corneum enhances the lamellar lipid structure; studies show that a 2% concentration can increase barrier repair speed by 30%. Two parts provide basic repair, while five parts are suitable for dry / sensitive skin; melting temperature should be controlled to avoid crystallization.

[0036] Glycerin is used as a humectant moisturizer to provide instant hydration. The three hydroxyl groups in the glycerin molecule form hydrogen bonds with water molecules, allowing it to absorb up to twice its own weight in water even in low humidity conditions. Three parts balance moisturizing and skin feel, while seven parts may result in a sticky feeling, which is synergistically regulated by sodium hyaluronate.

[0037] Artemisinin in Artemisia annua extract contains ≥5% for anti-inflammatory and antibacterial effects. Artemisinin reduces the release of inflammatory factors; a 1% concentration can reduce the erythema index by 25%. 1.5 parts provide basic anti-inflammatory effects, while 3.5 parts are suitable for acne / eczema-prone skin. Low-temperature addition is necessary to prevent artemisinin degradation.

[0038] Green tea extract contains ≥40% tea polyphenols, which are used for anti-oxidation and photoprotection. Tea polyphenols scavenge free radicals and reduce UV-induced DNA damage. One part provides daily antioxidant protection, while three parts enhance photoprotection. pH control is necessary to prevent the oxidation of tea polyphenols under alkaline conditions.

[0039] Rhodiola rosea extract containing ≥3% rhodioloside is used for anti-fatigue and skin brightening. Rhodioloside promotes cellular energy metabolism; studies show that a 0.5% concentration can improve skin radiance by 15%. 0.5 parts is for basic brightening, and 2 parts is suitable for dull skin; pH monitoring is necessary to prevent glycoside hydrolysis.

[0040] Sodium hyaluronate is used for deep moisturizing and lubrication. Large molecules of sodium hyaluronate form a film on the skin surface, while smaller molecules penetrate the dermis to absorb water and swell. 0.5 parts provide basic moisturizing, while 1.2 parts enhance lubrication. Dissolve in stages to prevent clumping.

[0041] Phospholipid solution is used to encapsulate Poria cocos extract to form liposomes, improving transdermal absorption. A stable bilayer is constructed by a 1:1 molar ratio of hydrogenated lecithin to cholesterol, achieving an encapsulation rate of up to 85%. Six parts are sufficient for basic encapsulation, while ten parts are suitable for high-concentration extracts, requiring control of ethanol residue.

[0042] A natural preservative mixture of 1,2-hexanediol and p-hydroxyacetophenone in a 2:1 ratio is used for antibacterial purposes and is non-irritating. 1,2-hexanediol disrupts bacterial cell membranes, while p-hydroxyacetophenone inhibits enzyme activity; the combination increases preservative efficiency by 40%. 0.8 parts provide basic preservative protection, while 1.5 parts are suitable for high-temperature environments and require pre-dissolution to prevent precipitation.

[0043] Deionized water is used as a solvent to adjust viscosity. The conductivity of deionized water is <1 μS / cm to prevent metal ions from catalyzing the oxidation of components. The total weight is dynamically adjusted based on the total amount of other components to ensure a total weight of 100.

[0044] Example 3: The present invention provides a technical solution: a composition containing Poria cocos extract, comprising the following components in parts by weight: 6 parts Poria cocos extract, 3 parts ceramide, 2.5 parts Artemisia annua extract, 2 parts green tea extract, 1.5 parts Rhodiola rosea extract, 5 parts glycerin, 8 parts phospholipid solution, 0.8 parts sodium hyaluronate, 1.2 parts natural preservative, and the balance being deionized water.

[0045] The core active ingredients in Poria cocos extract include Poria cocos polysaccharide and Poria cocos acid. The content of Poria cocos acid is ≥10% and the content of Poria cocos polysaccharide is ≥25%. Among them, the main functions of Poria cocos polysaccharide are anti-oxidation and moisturizing, while the main functions of Poria cocos acid are anti-inflammatory and whitening.

[0046] Poria cocos polysaccharides reduce transepidermal water loss by forming a hydration film; experiments show that a 0.5% concentration can reduce TEWL by 20%. Poria cocos acid inhibits tyrosinase activity and melanin production. 4-8 parts ensure sufficient moisturizing to enhance whitening; excessive amounts may affect liposome encapsulation efficiency.

[0047] Ceramides are used to repair the skin barrier and reduce moisture loss. Replenishing ceramides lost in the stratum corneum enhances the lamellar lipid structure; studies show that a 2% concentration can increase barrier repair speed by 30%. Two parts provide basic repair, while five parts are suitable for dry / sensitive skin; melting temperature should be controlled to avoid crystallization.

[0048] Glycerin is used as a humectant moisturizer to provide instant hydration. The three hydroxyl groups in the glycerin molecule form hydrogen bonds with water molecules, allowing it to absorb up to twice its own weight in water even in low humidity conditions. Three parts balance moisturizing and skin feel, while seven parts may result in a sticky feeling, which is synergistically regulated by sodium hyaluronate.

[0049] Artemisinin in Artemisia annua extract contains ≥5% for anti-inflammatory and antibacterial effects. Artemisinin reduces the release of inflammatory factors; a 1% concentration can reduce the erythema index by 25%. 1.5 parts provide basic anti-inflammatory effects, while 3.5 parts are suitable for acne / eczema-prone skin. Low-temperature addition is necessary to prevent artemisinin degradation.

[0050] Green tea extract contains ≥40% tea polyphenols, which are used for anti-oxidation and photoprotection. Tea polyphenols scavenge free radicals and reduce UV-induced DNA damage. One part provides daily antioxidant protection, while three parts enhance photoprotection. pH control is necessary to prevent the oxidation of tea polyphenols under alkaline conditions.

[0051] Rhodiola rosea extract containing ≥3% rhodioloside is used for anti-fatigue and skin brightening. Rhodioloside promotes cellular energy metabolism; studies show that a 0.5% concentration can improve skin radiance by 15%. 0.5 parts is for basic brightening, and 2 parts is suitable for dull skin; pH monitoring is necessary to prevent glycoside hydrolysis.

[0052] Sodium hyaluronate is used for deep moisturizing and lubrication. Large molecules of sodium hyaluronate form a film on the skin surface, while smaller molecules penetrate the dermis to absorb water and swell. 0.5 parts provide basic moisturizing, while 1.2 parts enhance lubrication. Dissolve in stages to prevent clumping.

[0053] Phospholipid solution is used to encapsulate Poria cocos extract to form liposomes, improving transdermal absorption. A stable bilayer is constructed by a 1:1 molar ratio of hydrogenated lecithin to cholesterol, achieving an encapsulation rate of up to 85%. Six parts are sufficient for basic encapsulation, while ten parts are suitable for high-concentration extracts, requiring control of ethanol residue.

[0054] A natural preservative mixture of 1,2-hexanediol and p-hydroxyacetophenone in a 2:1 ratio is used for antibacterial purposes and is non-irritating. 1,2-hexanediol disrupts bacterial cell membranes, while p-hydroxyacetophenone inhibits enzyme activity; the combination increases preservative efficiency by 40%. 0.8 parts provide basic preservative protection, while 1.5 parts are suitable for high-temperature environments and require pre-dissolution to prevent precipitation.

[0055] Deionized water is used as a solvent to adjust viscosity. The conductivity of deionized water is <1 μS / cm to prevent metal ions from catalyzing the oxidation of components. The total weight is dynamically adjusted based on the total amount of other components to ensure a total weight of 100.

[0056] Example 4: The present invention provides a technical solution: a composition containing Poria cocos extract, comprising the following components in parts by weight: 8 parts Poria cocos extract, 5 parts ceramide, 3.5 parts Artemisia annua extract, 3 parts green tea extract, 2 parts Rhodiola rosea extract, 7 parts glycerin, 10 parts phospholipid solution, 1.2 parts sodium hyaluronate, 1.5 parts natural preservative, and the balance being deionized water.

[0057] The core active ingredients in Poria cocos extract include Poria cocos polysaccharide and Poria cocos acid. The content of Poria cocos acid is ≥10% and the content of Poria cocos polysaccharide is ≥25%. Among them, the main functions of Poria cocos polysaccharide are anti-oxidation and moisturizing, while the main functions of Poria cocos acid are anti-inflammatory and whitening.

[0058] Poria cocos polysaccharides reduce transepidermal water loss by forming a hydration film; experiments show that a 0.5% concentration can reduce TEWL by 20%. Poria cocos acid inhibits tyrosinase activity and melanin production. 4-8 parts ensure sufficient moisturizing to enhance whitening; excessive amounts may affect liposome encapsulation efficiency.

[0059] Ceramides are used to repair the skin barrier and reduce moisture loss. Replenishing ceramides lost in the stratum corneum enhances the lamellar lipid structure; studies show that a 2% concentration can increase barrier repair speed by 30%. Two parts provide basic repair, while five parts are suitable for dry / sensitive skin; melting temperature should be controlled to avoid crystallization.

[0060] Glycerin is used as a humectant moisturizer to provide instant hydration. The three hydroxyl groups in the glycerin molecule form hydrogen bonds with water molecules, allowing it to absorb up to twice its own weight in water even in low humidity conditions. Three parts balance moisturizing and skin feel, while seven parts may result in a sticky feeling, which is synergistically regulated by sodium hyaluronate.

[0061] Artemisinin in Artemisia annua extract contains ≥5% for anti-inflammatory and antibacterial effects. Artemisinin reduces the release of inflammatory factors; a 1% concentration can reduce the erythema index by 25%. 1.5 parts provide basic anti-inflammatory effects, while 3.5 parts are suitable for acne / eczema-prone skin. Low-temperature addition is necessary to prevent artemisinin degradation.

[0062] Green tea extract contains ≥40% tea polyphenols, which are used for anti-oxidation and photoprotection. Tea polyphenols scavenge free radicals and reduce UV-induced DNA damage. One part provides daily antioxidant protection, while three parts enhance photoprotection. pH control is necessary to prevent the oxidation of tea polyphenols under alkaline conditions.

[0063] Rhodiola rosea extract containing ≥3% rhodioloside is used for anti-fatigue and skin brightening. Rhodioloside promotes cellular energy metabolism; studies show that a 0.5% concentration can improve skin radiance by 15%. 0.5 parts is for basic brightening, and 2 parts is suitable for dull skin; pH monitoring is necessary to prevent glycoside hydrolysis.

[0064] Sodium hyaluronate is used for deep moisturizing and lubrication. Large molecules of sodium hyaluronate form a film on the skin surface, while smaller molecules penetrate the dermis to absorb water and swell. 0.5 parts provide basic moisturizing, while 1.2 parts enhance lubrication. Dissolve in stages to prevent clumping.

[0065] Phospholipid solution is used to encapsulate Poria cocos extract to form liposomes, improving transdermal absorption. A stable bilayer is constructed by a 1:1 molar ratio of hydrogenated lecithin to cholesterol, achieving an encapsulation rate of up to 85%. Six parts are sufficient for basic encapsulation, while ten parts are suitable for high-concentration extracts, requiring control of ethanol residue.

[0066] A natural preservative mixture of 1,2-hexanediol and p-hydroxyacetophenone in a 2:1 ratio is used for antibacterial purposes and is non-irritating. 1,2-hexanediol disrupts bacterial cell membranes, while p-hydroxyacetophenone inhibits enzyme activity; the combination increases preservative efficiency by 40%. 0.8 parts provide basic preservative protection, while 1.5 parts are suitable for high-temperature environments and require pre-dissolution to prevent precipitation.

[0067] Deionized water is used as a solvent to adjust viscosity. The conductivity of deionized water is <1 μS / cm to prevent metal ions from catalyzing the oxidation of components. The total weight is dynamically adjusted based on the total amount of other components to ensure a total weight of 100.

[0068] The natural preservatives are 1,2-hexanediol and p-hydroxyacetophenone, with a weight ratio of 2:1 between the two.

[0069] Example 5: Experiments were conducted on the emulsions prepared in Examples 2, 3, and 4 regarding moisturizing and other aspects. Among them: Moisturizing effect: Using a skin moisture meter, an equal amount of the composition was applied to the inner forearm of the subject, and the skin moisture content of the same area was measured 24 hours later to calculate the percentage increase.

[0070] Antioxidant capacity: The DPPH free radical scavenging experiment was used. The composition sample was mixed with DPPH solution, the absorbance of the solution after the reaction was measured, and the free radical scavenging rate was calculated.

[0071] Anti-inflammatory effect: The level of inflammatory factor IL-6 in the cell culture supernatant before and after treatment was detected by ELISA, and the reduction rate was calculated.

[0072] Skin soothing effect: After applying the composition to a simulated erythema model on the subject's face, the change in erythema area was measured using image analysis software, and the reduction rate was calculated.

[0073] Stability: The composition was placed at 4°C and 25°C and its appearance was observed weekly, including layering, precipitation, color change, etc., and quantitative analysis was performed using a colorimeter.

[0074] The experimental results are as follows:

[0075] The experimental results show that as the content of moisturizing ingredients such as Poria cocos extract, ceramide, and sodium hyaluronate increases, the moisturizing effect of the composition is significantly enhanced, and the skin moisture content increase rate increases from 15% to 28% after 24 hours.

[0076] The addition of artemisia annua extract, green tea extract, and rhodiola rosea extract effectively enhances the antioxidant capacity of the composition, increasing the DPPH free radical scavenging rate from 45% to 75%, which helps resist environmental damage to the skin.

[0077] The increase in anti-inflammatory components in the composition significantly reduced the level of the inflammatory factor IL-6, while the reduction rate of erythema area increased, indicating that it has good anti-inflammatory and skin-soothing effects.

[0078] Despite the increased content of each component, the composition exhibited good stability over 4 weeks, with no stratification and minimal color change, ensuring the long-term effectiveness of the product.

[0079] In conclusion, by adjusting the content of each component in the composition containing Poria cocos extract, its moisturizing, antioxidant, anti-inflammatory, and skin-soothing effects can be significantly improved, while maintaining good stability, providing a scientific basis for the development of highly effective and safe skin care products.

[0080] Example 6: Please refer to Figure 1 The present invention provides a technical solution: a method for preparing a composition containing Poria cocos extract, comprising the following steps: Step 1: Dissolve Poria cocos extract in a phospholipid solution and prepare a liposome solution with a particle size of less than 80 nm using a high-pressure homogenizer. The high-pressure homogenizer is set to a pressure of 600-800 bar and cyclically repeated 5-8 times. The particle size ≤80 nm is monitored in real time using a dynamic light scattering instrument. The transdermal absorption rate of small-particle-size liposomes is increased by 3 times.

[0081] Step 2: The liposome solution from Step 1 is subjected to rotary evaporation to remove ethanol, yielding an aqueous dispersion. The rotary evaporator is set to a temperature of 35-40℃ and a vacuum degree ≥0.09MPa. Ethanol residue <0.5% is detected by gas chromatography to avoid skin irritation. Phospholipid oxidation value <1.0 meq / kg is measured by peroxide value to extend shelf life.

[0082] Step 3: Heat the ceramide until melted, then slowly add it to the aqueous dispersion, stirring until homogeneous; use a magnetic stirrer equipped with a temperature control module. Melting temperature: 60℃, stirring speed: 800-1000 rpm. Ceramide particle size D50 ≤ 5μm to avoid crystallization. After mixing with the liposome solution, the barrier repair efficiency is increased by 25%.

[0083] Step 4: Add glycerin and sodium hyaluronate sequentially to deionized water, stirring at 50-60 degrees Celsius until completely dissolved; use a constant temperature water bath equipped with a stirring paddle. Maintain a temperature of 40-45 degrees Celsius and a dissolution time of 20 minutes. Ensure the molecular weight of the sodium hyaluronate is >1000kDa, using a viscosity test to guarantee its moisturizing properties. After complete dissolution of glycerin, the solution should have a transmittance >95% to avoid turbidity.

[0084] Step 5: After cooling the solution from Step 4 to below 40℃, add Artemisia annua extract, green tea extract, and Rhodiola rosea extract, and stir until homogeneous; measure the pH using a pH meter. Rhodiola rosea glycosides exhibit optimal stability at pH 5-7, with a temperature of 30-35℃. Low-temperature addition prevents oxidation of tea polyphenols.

[0085] Step Six: Slowly add the aqueous dispersion obtained in Step Three to the solution obtained in Step Five, and homogenize and stir to obtain the primary emulsion; use a high-shear homogenizer at a pressure of 200-300 bar, and cycle 3 times. The particle size of the primary emulsion, D50, should be ≤100 nm to avoid excessive fragmentation by subsequent ultrasonication. The binding rate of ceramides to liposomes should be >90%, as determined by centrifugation.

[0086] Step 7: Ultrasonically stir the colostrum to further reduce the particle size to 50-70nm; use an ultrasonic cell disruptor. Power 200-300W, pulse mode, on for 3 seconds / off for 2 seconds. This reduces the particle size to 50-70nm (improving transdermal absorption). Cool the mixture in an ice bath to maintain a temperature below 30℃ to prevent the degradation of tea polyphenols.

[0087] Step 8: After cooling the colostrum from Step 7 to 30°C, add 1,2-hexanediol and p-hydroxyacetophenone, and stir until homogeneous; use a magnetic stirrer with a temperature control module. Maintain a temperature of 30°C and a stirring speed of 600-800 rpm. Ensure the preservative is evenly distributed. Pre-dissolve the preservative to prevent precipitation; microscopic observation reveals no crystallization.

[0088] Step 9: After sterilization by filtration through a microporous membrane, the finished emulsion is obtained. Polyethersulfone membrane, pore size 0.22 μm. Pressure ≤ 0.2 MPa. Sterilization rate > 99.99%, total bacterial count detected. Liposome retention rate > 95%, particle size showed no significant change.

[0089] The phospholipid solution is a mixed solution obtained by adding an appropriate amount of ethanol to hydrogenated lecithin and cholesterol at a molar ratio of 1:1.

[0090] In step two, during rotary evaporation, the temperature is controlled at 35-40℃, the vacuum degree is greater than or equal to 0.09 MPa, and the residual ethanol is detected by gas chromatography after evaporation to ensure that the ethanol content is less than 0.5%. In step five, when adding Rhodiola rosea extract, the pH of the solution was tested to be between 5 and 7.

[0091] Example 7: The present invention provides a technical solution: the application of a composition containing Poria cocos extract in skin care products.

[0092] Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

Claims

1. A composition containing Poria cocos extract, characterized in that: The product comprises the following components by weight: 4-8 parts Poria cocos extract, 2-5 parts ceramide, 1.5-3.5 parts Artemisia annua extract, 1-3 parts green tea extract, 0.5-2 parts Rhodiola rosea extract, 3-7 parts glycerin, 6-10 parts phospholipid solution, 0.5-1.2 parts sodium hyaluronate, 0.8-1.5 parts natural preservative, and the balance being deionized water.

2. The composition containing Poria cocos extract according to claim 1, characterized in that: The product comprises the following components by weight: 4 parts Poria cocos extract, 2 parts ceramide, 1.5 parts Artemisia annua extract, 1 part green tea extract, 0.5 parts Rhodiola rosea extract, 3 parts glycerin, 6 parts phospholipid solution, 0.5 parts sodium hyaluronate, 0.8 parts natural preservative, and the balance being deionized water.

3. The composition containing Poria cocos extract according to claim 1, characterized in that: The product comprises the following components by weight: 6 parts Poria cocos extract, 3 parts ceramide, 2.5 parts Artemisia annua extract, 2 parts green tea extract, 1.5 parts Rhodiola rosea extract, 5 parts glycerin, 8 parts phospholipid solution, 0.8 parts sodium hyaluronate, 1.2 parts natural preservative, and the balance being deionized water.

4. The composition containing Poria cocos extract according to claim 1, characterized in that: The product comprises the following components by weight: 8 parts Poria cocos extract, 5 parts ceramide, 3.5 parts Artemisia annua extract, 3 parts green tea extract, 2 parts Rhodiola rosea extract, 7 parts glycerin, 10 parts phospholipid solution, 1.2 parts sodium hyaluronate, 1.5 parts natural preservative, and the balance being deionized water.

5. A composition containing Poria cocos extract according to any one of claims 1-4, characterized in that: The natural preservatives are 1,2-hexanediol and p-hydroxyacetophenone, with a weight ratio of 2:1 between the two.

6. The method for preparing a composition containing Poria cocos extract according to claim 5, characterized in that: Includes the following steps: Step 1: Dissolve the extract of Poria cocos in a phospholipid solution and prepare a liposome solution with a particle size of less than 80 nm using a high-pressure homogenizer; Step 2: Rotary evaporate the liposome solution from Step 1 to remove ethanol and obtain an aqueous dispersion; Step 3: Heat the ceramide until it melts, then slowly add it to the aqueous dispersion and stir until homogeneous; Step 4: Add glycerin and sodium hyaluronate to deionized water in sequence, and stir at 50-60 degrees Celsius until completely dissolved; Step 5: After cooling the solution from Step 4 to below 40°C, add Artemisia annua extract, green tea extract, and Rhodiola rosea extract, and stir until homogeneous; Step 6: Slowly add the aqueous dispersion obtained in Step 3 to the solution obtained in Step 5, and stir homogenize to obtain the pre-emulsion; Step 7: Ultrasonic stirring of the colostrum to further reduce the particle size to 50-70 nm; Step 8: After the colostrum from Step 7 has cooled to 30°C, add 1,2-hexanediol and p-hydroxyacetophenone, and stir until homogeneous; Step 9: After sterilization by filtration through a microporous membrane, the finished emulsion is obtained.

7. The method for preparing a composition containing Poria cocos extract according to claim 6, characterized in that: The phospholipid solution is a mixed solution obtained by adding an appropriate amount of ethanol to hydrogenated lecithin and cholesterol at a molar ratio of 1:

1.

8. A method for preparing a composition containing Poria cocos extract according to claim 6, characterized in that: In step two, during rotary evaporation, the temperature is controlled at 35-40℃, the vacuum degree is greater than or equal to 0.09MPa, and the residual ethanol is detected by gas chromatography after evaporation to ensure that the ethanol content is less than 0.5%.

9. A method for preparing a composition containing Poria cocos extract according to claim 6, characterized in that: In step five, when adding Rhodiola rosea extract, the pH of the solution was tested to be between 5 and 7.

10. The application of a composition containing Poria cocos extract in skin care products.

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