Kit for carbon dioxide air bag

Abstract

The purpose of the present invention is to provide a kit for a carbon dioxide airbag, which is not susceptible to liquid dripping and which enables the generated carbon dioxide gas to effectively reach the skin. Specifically disclosed is a carbon dioxide airbag kit which is characterized by comprising a viscous composition (A) that contains a carbonate, a thickener, water, a gelling agent that is gelled by calcium ions, and a water-insoluble calcium salt, a carbon dioxide aid (B) that contains an acid and / or a substance that generates an acid by hydrolysis, and a sheet (C) that is formed by a sheet material (C) that is formed by a sheet material (C) that is formed by a sheet material (C) that is formed by a sheet material (C) that is formed by a sheet material (C) and a sheet material (C) that is formed by a sheet material (C) and a sheet material (C) that is formed by a sheet material (C). And a calcium salt which is easily soluble in water is attached to the sheet (C).

Description

Technical Field

[0001] This invention relates to a kit for a carbon dioxide gas bag that generates carbon dioxide gas. Background Technology

[0002] Carbon dioxide gas is known to promote blood circulation in the skin, subcutaneous tissue, and muscles and activate metabolism through transdermal (mucous membrane) absorption. Therefore, in recent years, topical agents that generate carbon dioxide gas (hereinafter referred to as "carbon dioxide gas bags") have attracted attention in the beauty and medical fields. These carbon dioxide gas bags are designed to generate carbon dioxide gas and are applied to the skin. Carbon dioxide is generated within the carbon dioxide gas bag applied to the skin, and the generated carbon dioxide is released through the contact surface with the skin and absorbed transdermally.

[0003] Carbon dioxide gas bags require a continuous generation of carbon dioxide gas, and the generated carbon dioxide gas must be able to move to the outer surface of the bag to allow for transdermal absorption. Therefore, carbon dioxide gas bags typically use a viscous material that exhibits flowability. However, carbon dioxide gas bags made with viscous materials that exhibit flowability sometimes drip inside the bag, and there is also the issue of needing to wipe and clean them after filling.

[0004] Therefore, gelled carbon dioxide gas bags have been developed. For example, Patent Document 1 discloses a composition for preparing a carbon dioxide topical agent (hereinafter also referred to as "the carbon dioxide gas bag of Patent Document 1"), which contains a substance that hydrolyzes to produce acid, a carbonate, a thickener, water, a gelling agent that gels via calcium ions, and a calcium salt that is sparingly soluble in water. In the carbon dioxide gas bag of Patent Document 1, calcium ions generated from the water-sparing calcium salt act on the gelling agent, thereby causing the carbon dioxide gas bag to gel.

[0005] Existing technical documents

[0006] Patent documents

[0007] Patent Document 1: International Publication No. 2006 / 080398. Summary of the Invention

[0008] Technical problems to be solved

[0009] If the carbon dioxide gas bag gels, the movement of the generated carbon dioxide gas is blocked by the gel, making it difficult for the carbon dioxide gas to reach the skin. Therefore, even gelled carbon dioxide gas bags are required to remain gelled during the transdermal absorption of carbon dioxide.

[0010] In the carbon dioxide gas bag of Patent Document 1, the rate of gelation is reduced by using a water-insoluble calcium salt as a source of calcium ions that act on the gelling agent. Compared to water-soluble calcium salts, the water-insoluble calcium salt has lower solubility in water and generates calcium ions through reaction with acid, thus slowing down the gelation reaction. Therefore, the carbon dioxide gas bag of Patent Document 1 aims to achieve both gelation and the delivery of carbon dioxide to the skin.

[0011] However, the carbon dioxide gas bag in Patent Document 1 exhibits fluidity (viscousness) before gelation. Therefore, even the carbon dioxide gas bag in Patent Document 1 still has the problem of dripping easily during the period before gelation.

[0012] Furthermore, in the carbon dioxide gas bag of Patent Document 1, the generated carbon dioxide gas can move to the skin-contact surface by being pre-set to a fluid, viscous state until gelation. However, the carbon dioxide gas generated in the packaging diffuses in all directions, thus being released not only from the skin-contact surface but also from the outer surface outside the skin-contact surface. In other words, the carbon dioxide gas bag of Patent Document 1 also has the problem of not being able to effectively deliver the generated carbon dioxide gas to the skin.

[0013] This invention was made to solve the above-mentioned problems, and its purpose is to provide a carbon dioxide bag kit that is less prone to liquid dripping and allows the generated carbon dioxide gas to effectively reach the skin.

[0014] Technical solution

[0015] The main points of this invention are as follows.

[0016] [1]. A kit for a carbon dioxide gas bag, characterized in that it comprises an adhesive composition (A), a carbon dioxide additive (B), and a sheet (C), wherein the adhesive composition (A) comprises a carbonate, a thickener, water, a gelling agent that gels via calcium ions, and a calcium salt that is poorly soluble in water, the carbon dioxide additive (B) comprises at least one of an acid and a substance that produces an acid through hydrolysis, and the sheet (C) is coated with a calcium salt that is readily soluble in water.

[0017] [2]. The carbon dioxide gas bag kit according to [1], wherein the sheet (C) is a fiber sheet made of fibers.

[0018] [3]. The carbon dioxide gas bag kit according to [1] or [2], wherein the amount of water-soluble calcium salt adhering to the sheet (C) is 1.0-100 g / m². 2 .

[0019] [4]. A carbon dioxide gas bag kit according to any one of [1] to [3], wherein the water-soluble calcium salt is a calcium salt with a solubility of more than 10.0 g / 100 ml in water at 20°C and pH 7.0.

[0020] [5]. A sheet (C) is characterized in that it is used to contact a mixture of an adhesive composition (A) and a carbon dioxide additive (B), wherein the adhesive composition (A) comprises a carbonate, a thickener, water, a gelling agent that gels via calcium ions, and a calcium salt that is poorly soluble in water, wherein the carbon dioxide additive (B) comprises at least one of an acid and a substance that produces an acid through hydrolysis, and wherein the sheet (C) is coated with a calcium salt that is readily soluble in water.

[0021] [6]. The sheet (C) according to [5] is a fiber sheet made of fibers.

[0022] [7]. The sheet (C) according to [5] or [6], wherein the amount of water-soluble calcium salt attached is 1.0-100 g / m². 2 .

[0023] [8]. Sheet (C) according to any one of [5] to [7], wherein the water-soluble calcium salt is a calcium salt with a solubility of more than 10.0 g / 100 ml in water at 20°C and pH 7.0.

[0024] Beneficial effects

[0025] According to the present invention, a carbon dioxide bag kit is provided that is less prone to liquid dripping and allows the generated carbon dioxide gas to effectively reach the skin. Detailed Implementation

[0026] Hereinafter, one embodiment of the present invention will be described.

[0027] This embodiment is a kit for a carbon dioxide bag comprising an adhesive composition (A), a carbon dioxide additive (B), and a sheet (C). First, the adhesive composition (A) will be described in the context of the adhesive composition (A), the carbon dioxide additive (B), and the sheet (C).

[0028] The viscous composition (A) is a composition comprising at least a carbonate, a thickener, water, a gelling agent that gels via calcium ions, and a calcium salt that is poorly soluble in water.

[0029] The carbonate contained in the viscous composition (A) is a source of carbon dioxide gas, producing carbon dioxide (carbon dioxide gas) through reaction with an acid. Any carbonate that reacts with an acid to produce carbon dioxide can be used; examples include ammonium carbonate, ammonium bicarbonate, potassium carbonate, potassium bicarbonate, sesquicarbonate, sodium carbonate, sodium bicarbonate, sesquicarbonate, lithium carbonate, lithium bicarbonate, lithium sesquicarbonate, cesium carbonate, cesium bicarbonate, cesium sesquicarbonate, magnesium carbonate, magnesium bicarbonate, calcium bicarbonate, calcium carbonate, basic magnesium carbonate, and barium carbonate. One or more of these can be used. Among the above-mentioned carbonates, water-soluble carbonates such as sodium bicarbonate and sodium carbonate are preferred.

[0030] The content of carbonates is not particularly limited. For example, it can be set to 0.1-10% by mass relative to 100% by mass of the viscous composition (A), preferably 0.1-5% by mass. When the viscous composition (A) contains two or more carbonates, the above-mentioned carbonate content refers to the total amount of carbonates contained.

[0031] It should be noted that the aforementioned carbonates also include calcium salts such as calcium carbonate, which are sparingly soluble in water. Regarding substances that are both carbonates and sparingly soluble calcium salts, their presence can be considered as the presence of both carbonates and sparingly soluble calcium salts in the viscous composition (A). In the viscous composition (A), in addition to substances that are both carbonates and sparingly soluble calcium salts, it may further contain carbonates different from these substances, or it may further contain sparingly soluble calcium salts different from these substances.

[0032] The thickener contained in the viscous composition (A) is not particularly limited, and one or more selected from natural polymers, semi-synthetic polymers, synthetic polymers, and inorganic substances may be used. In addition, the thickener may have any properties of acidity, neutrality, or alkalinity, but from the viewpoint of timely generation of carbon dioxide gas, neutrality or alkalinity is preferred.

[0033] Examples of substances that can be used as neutral or alkaline thickeners include the following.

[0034] Examples of natural polymers (neutral or alkaline thickeners) include plant-based polymers such as gum arabic, carrageenan, galactomannan, agar, quince seed, guar gum, tragacanth gum, mannan, locust bean gum, wheat starch, rice starch, tara gum, corn starch, and potato starch; microbial polymers such as gel polysaccharides, xanthan gum, succinyl dextran, dextran, and pullulan; and protein polymers such as albumin, casein, collagen, gelatin, and silk protein. One or more of these can be used.

[0035] As a semi-synthetic polymer (neutral or alkaline thickener), examples include ethyl cellulose, carboxymethyl cellulose and its salts, carboxymethyl ethyl cellulose and its salts, carboxymethyl starch and its salts, cross-linked carboxymethyl cellulose and its salts, crystalline cellulose, cellulose acetate, cellulose acetate phthalate, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl methyl cellulose phthalate, methyl cellulose, methyl hydroxypropyl cellulose, and other cellulose-based polymers; α-starch, partially α-starch, carboxymethyl starch, dextrin, methyl starch, and other starch-based polymers; sodium alginate, potassium alginate, ammonium alginate, propylene glycol alginate, and other alginate-based polymers; sodium chondroitin sulfate, sodium hyaluronate, and other polysaccharide-based polymers. One or more of these can be used.

[0036] Examples of synthetic polymers (neutral or alkaline thickeners) include sodium polyacrylate, polyvinyl acetal diethylaminoacetate, polyvinyl alcohol, polyvinylpyrrolidone, methacrylate-ethyl acrylate copolymer, methacrylate-ethyl methacrylate copolymer, ethyl methacrylate-trimethylammonium methacrylate copolymer, and dimethylaminoethyl methacrylate-methyl methacrylate copolymer. One or more of these may be used.

[0037] Examples of inorganic (neutral or alkaline) thickeners include hydrated silica, colloidal alumina, bentonite, and pyrolusite; one or more of these may be used.

[0038] Examples of acidic thickeners include the following substances.

[0039] Examples of natural polymers (acidic thickeners) include alginic acid, pectin, and hyaluronic acid; examples of semi-synthetic polymers (acidic thickeners) include carboxyvinyl polymers; and examples of inorganic substances (acidic thickeners) include light silicic anhydride. One or more of these substances may be used.

[0040] The content of the thickener is not particularly limited. For example, it can be set to 0.5-20% by mass relative to 100% by mass of the viscous composition (A), preferably 1.0-10% by mass. When the viscous composition (A) contains two or more thickeners, the above-mentioned content of the thickener refers to the total amount of the thickeners contained.

[0041] The aforementioned thickener also includes a gelling agent such as sodium alginate that gels via calcium ions. Regarding a substance that serves as both a thickener and a gelling agent that gels via calcium ions, by containing such a substance, the viscous composition (A) can be considered to contain both a thickener and a gelling agent that gels via calcium ions. In addition to a substance that serves as a thickener and a gelling agent that gels via calcium ions, the viscous composition (A) may also contain a thickener different from that substance, or it may also contain a gelling agent that gels via calcium ions different from that substance.

[0042] The water content in the viscous composition (A) is not particularly limited, and natural water, tap water, distilled water, purified water, etc. can be used.

[0043] The water content is not particularly limited; for example, it can be set to 40-95% by mass relative to 100% by mass of the viscous composition (A).

[0044] The gelling agent contained in the viscous composition (A) that gels via calcium ions is any substance that gels via calcium ions and is not particularly limited. Examples include sodium alginate, carrageenan, tara gum, and locust bean gum, and one or more of these can be used. Among the above-mentioned gelling agents, sodium alginate is preferred as the gelling agent that gels via calcium ions. It should be noted that, in this specification, a gel refers to a gel in which molecules are interconnected to form a three-dimensional mesh structure, and its interior is filled with a solvent such as water.

[0045] The content of the gelling agent that gels via calcium ions is not particularly limited. For example, it can be set to 0.5-10% by mass relative to 100% by mass of the viscous composition (A), preferably 1.0-5.0% by mass. When the viscous composition (A) contains two or more gelling agents, the above-mentioned content of gelling agents refers to the total amount of the gelling agents contained.

[0046] The water-insoluble calcium salt contained in the viscous composition (A) is a calcium salt with a solubility of less than 3.7 g / 100 ml in water at 25°C and pH 7.0. Examples of water-insoluble calcium salts contained in the viscous composition (A) include calcium carbonate, calcium sulfate, calcium alginate, calcium pyrophosphate, calcium dihydrogen phosphate, calcium hydrogen phosphate, calcium silicate, calcium gluconate, and calcium benzoate; one or more of these may be used. Among the above-mentioned water-insoluble calcium salts, calcium carbonate is preferred.

[0047] The content of water-insoluble calcium salts is not particularly limited. For example, it can be set to 0.1-5% by mass relative to 100% by mass of the viscous composition (A), preferably 0.3-3.0% by mass. When the viscous composition (A) contains two or more water-insoluble calcium salts, the above-mentioned content of water-insoluble calcium salts refers to the total amount of water-insoluble calcium salts contained therein.

[0048] The viscous composition (A) may consist solely of the aforementioned carbonates, thickeners, water, gelling agents that gel via calcium ions, and water-insoluble calcium salts, but may also contain other components besides these. Examples of such other components include known topical agents and ingredients found in cosmetics; specifically, examples include fragrances, pigments, surfactants, oils, moisturizers, alcohols, preservatives, antioxidants, pH adjusters, dispersants, metal ion chelating agents, anti-staining agents, ultraviolet absorbers / scatterers, vitamins, amino acids, arbutin, kojic acid, nutrients, anti-inflammatory agents, vasodilators, hormones, astringents, antihistamines, bactericides, sebum inhibitors, keratolytic / exfoliating agents, anti-seborrheic agents, and antipruritic agents; it may contain one or more of these.

[0049] The viscous composition (A) is a viscous substance with a viscosity higher than that of water; more specifically, it is a viscous substance (sol) exhibiting fluidity. There is no particular limitation on the viscosity of the viscous composition (A), but examples can be given as 20,000-1,100,000 mPa·s, preferably 50,000-1,100,000 mPa·s. It should be noted that the viscosity refers to that measured using a Type B viscometer at 25°C, a rotation speed of 0.5 rpm, and a spindle number...

[0050] Viscosity measured at LV4.

[0051] From the viewpoint of application to the skin, the pH of the viscous composition (A) is preferably weakly alkaline to weakly acidic (e.g., 4-9), and from the viewpoint of timely generation of carbon dioxide, it is preferably weakly alkaline to neutral (e.g., 7-9).

[0052] The viscous composition (A) can be manufactured by appropriately mixing carbonates, thickeners, water, gelling agents that gel via calcium ions, and water-insoluble calcium salts with other ingredients as needed.

[0053] Next, the carbon dioxide additive (B) contained in the carbon dioxide bag kit of this embodiment will be described.

[0054] The carbon dioxide auxiliary agent (B) is an agent used to generate carbon dioxide in the viscous composition (A) by mixing with it, and includes at least one of an acid and a substance that hydrolyzes to produce an acid.

[0055] The carbon dioxide additive (B) may contain any of the following acids: organic acids and inorganic acids, and may use one or more of them. The acid may be in the form of a salt.

[0056] As organic acids, examples include: straight-chain fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, and valeric acid; dicarboxylic acids such as oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid, and terephthalic acid; acidic amino acids such as glutamic acid and aspartic acid; and hydroxy acids such as glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-hydroxybutyric acid, glyceric acid, malonic acid, salicylic acid, gallic acid, troponic acid, ascorbic acid, and gluconic acid. One or more of these can be used.

[0057] Examples of inorganic acids include phosphoric acid, potassium dihydrogen phosphate, sodium dihydrogen phosphate, sodium sulfite, potassium sulfite, sodium metabisulfite, potassium metabisulfite, acidic sodium hexametaphosphate, acidic potassium hexametaphosphate, acidic sodium pyrophosphate, acidic potassium pyrophosphate, and aminosulfonic acid. One or more of these inorganic acids may be used.

[0058] The carbon dioxide additive (B) may contain any substance that hydrolyzes to produce acid, as long as it is a substance that hydrolyzes to produce acid through contact with water, without particular limitation. Examples include lactones and cyclic dimers of organic acids, and one or more such substances may be used. The substance that hydrolyzes to produce acid is preferably a cyclic dimer of lactones and / or organic acids in a crystalline state, preferably at least one selected from gluconic acid δ-lactone, pantothenic acid, D,L- or L-lactide (3,6-dimethyl-1,4-dioxane-2,5-dione), and D,L- or L-glycolic acid.

[0059] The acid content and the content of substances that produce acid through hydrolysis in the carbon dioxide additive (B) can be appropriately set considering the amount of carbon dioxide gas produced and the time until gelation. From the viewpoint of maximizing the transdermal absorption of carbon dioxide gas, the acid content is preferably 1-100 times (1-100 times by mass) relative to the carbonate content contained in the viscous composition (A), more preferably 1-50 times (1-50 times by mass), and even more preferably 1-10 times (1-10 times by mass). On the other hand, from the viewpoint of ensuring sufficient transdermal absorption of carbon dioxide gas, the acid content in the carbon dioxide additive (B) is preferably 1-500 times (1-500 times by mass) relative to the content of water-insoluble calcium salts contained in the viscous composition (A), more preferably 5-400 times (5-400 times by mass), and even more preferably 8-20 times (8-20 times by mass). It should be noted that when the carbon dioxide additive (B) contains both acid and a substance that produces acid through hydrolysis, the aforementioned content refers to the total content of both. When the carbon dioxide additive (B) contains only either acid or a substance that produces acid through hydrolysis, the aforementioned content refers to the content of only one of them.

[0060] Carbon dioxide additive (B) may consist solely of the aforementioned acids and substances that produce acids through hydrolysis, or it may contain other components besides these. Examples of other components include well-known topical agents and ingredients found in cosmetics, such as fragrances, pigments, surfactants, oils, moisturizers, alcohols, preservatives, antioxidants, pH adjusters, dispersants, metal ion chelating agents, anti-staining agents, ultraviolet absorbers / scatterers, excipients, adhesives, stabilizers, disintegrants, lubricants, dispersion media, vitamins, amino acids, arbutin, kojic acid, nutrients, anti-inflammatory agents, vasodilators, hormones, astringents, antihistamines, bactericides, sebum inhibitors, keratolytic / exfoliating agents, anti-seborrheic agents, and antipruritic agents; it may contain one or more of these.

[0061] The form of the carbon dioxide additive (B) is not particularly limited and can be any form, including liquid and solid, preferably solid, and more preferably granular, fine, or powdered material.

[0062] Carbon dioxide additive (B) can be manufactured by appropriately mixing the aforementioned acid, the substance that produces acid through hydrolysis, and other components as needed. Furthermore, when the carbon dioxide additive (B) is in granular form, granulation methods commonly used in the manufacture of pharmaceuticals, etc., such as compression molding, extrusion granulation, rotary granulation, spray granulation, and stirred granulation, can be used to achieve this granular form. When the carbon dioxide additive (B) is in granular form, its particle size is not particularly limited; for example, it can be set to 1μm-1000μm, preferably 5μm-600μm. It should be noted that the particle size refers to the particle size determined by sieving using a sieve.

[0063] Next, the sheet (C) included in the carbon dioxide bag kit of this embodiment will be described.

[0064] The sheet (C) is a sheet covered on the skin by contact with a mixture of carbon dioxide additive (B) and adhesive composition (A) (hereinafter also referred to as "mixture (A)(B)") applied to the skin, and is at least attached with water-soluble calcium salts.

[0065] The water-soluble calcium salts adhering to the sheet (C) are calcium salts with a solubility of 3.7 g / 100 ml or more in water at 25°C and pH 7.0. Examples of water-soluble calcium salts include calcium chloride, calcium chlorate, calcium perchlorate, calcium permanganate, calcium formate, calcium glycerophosphate, calcium glutamate, calcium acetate, calcium salicylate, calcium hypochlorite, calcium bromide, calcium bromate, calcium nitrate, calcium lactate, calcium pantothenate, calcium propionate, and calcium phosphorylated oligosaccharides; one or more of these may be used.

[0066] From the viewpoint of enabling the generated carbon dioxide gas to reach the skin more effectively, among the water-soluble calcium salts mentioned above, the preferred calcium salts are those with a solubility of 10.0 g / 100 ml or more in water at 20°C and pH 7.0, more preferably calcium salts with a solubility of 30.0 g / 100 ml or more in water at 20°C and pH 7.0, even more preferably calcium salts with a solubility of 50.0 g / 100 ml or more in water at 20°C and pH 7.0, and particularly preferably calcium chloride.

[0067] There is no particular limitation on the amount of water-soluble calcium salts adhering to the skin, but from the viewpoint of enabling the generated carbon dioxide gas to reach the skin more effectively, 1.0-100 g / m² is preferred. 2 More preferably, it is 1.5-80.0 g / m 2 More preferably, it is 2.3-55.8 g / m³. 2 It should be noted that the aforementioned amount of water-soluble calcium salts adhering (g / m³) 2The mass of water-soluble calcium per unit area of ​​the sheet is calculated by dividing the mass (g) of water-soluble calcium salts adhering to the sheet by the area (m²) of the sheet. 2 The area of ​​a sheet is calculated by referring to the projected area along its thickness (the area of ​​the upper or lower surface of the sheet), without considering the area of ​​the fine gaps and pores formed between the raw materials (e.g., fibers) constituting the sheet. Furthermore, when the sheet has openings, the area of ​​the openings is not considered within the sheet area (it is not included in the sheet area).

[0068] As long as the aforementioned water-soluble calcium salt is attached to the sheet (C), other components besides the water-soluble calcium salt may also be attached. Examples of such other components include, for example, ascorbate glucoside, 3-O-ethyl ascorbic acid, arbutin, sodium hyaluronate, hydrolyzed hyaluronic acid, hydrolyzed sodium hyaluronate, acetyl sodium hyaluronate, carboxymethyl sodium hyaluronate, hydrolyzed alkyl (C12-13) glycerides of hyaluronic acid, hydrolyzed collagen, nicotinamide, and dipotassium glycyrrhizate; one or more of these may be used.

[0069] The sheet (C) can be made of any material as long as it can adhere to water-soluble calcium salts, such as membranes, porous bodies, foams, nonwoven fabrics, woven fabrics, and paper.

[0070] Materials used as membranes, porous bodies, and foams include, for example, polyolefin resins (polyethylene, polypropylene, etc.), acrylic resins (polymethyl methacrylate, etc.), polyester resins (polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, etc.), polyvinyl alcohol, ethylene-vinyl alcohol copolymers, polyvinyl chloride, polyvinylidene chloride, polystyrene, polyurethane resins, polyacrylonitrile, fluorinated resins, styrene-isoprene-styrene block copolymers, styrene-butadiene-styrene block copolymers, and styrene-ethylene-propylene-styrene block copolymers.

[0071] Styrene-butadiene rubber, ethylene-vinyl acetate copolymer, polyamide, polysulfone, polyester, and thermoplastic elastomers such as styrene-based, polyester-based or copolymer rubbers may be used, and one or more of them may be used.

[0072] As materials for non-woven fabrics, woven fabrics, and paper, examples include rayon, polyamide, polyethylene, polyester resins such as polyethylene terephthalate, polyolefin resins such as polypropylene, polyester ether, polyurethane resins, acrylic resins, polyvinyl alcohol, polystyrene resins, cotton, linen, etc., and one or more of them can be used.

[0073] In the above materials, the sheet (C) is preferably a fiber sheet composed of fibers such as nonwoven fabric, woven fabric, or paper. When the sheet (C) is a fiber sheet, if the mixture (A) and (B) come into contact with the sheet (C), the water contained in the mixture (A) and (B) easily moves into the fine gaps between the fibers constituting the sheet (C) through capillary action. As a result, calcium ions are easily generated from the water-soluble calcium salts attached to the sheet (C), enabling the outer surface of the mixture (A) and (B) in contact with the sheet (C) to gel more quickly. The basis weight of the fiber sheet is not particularly limited, but can be exemplified as 10-120 g / m³. 2 .

[0074] The shape of the sheet (C) is not particularly limited and can be appropriately set according to the areas where the coating mixture (A) and (B) are applied. Alternatively, holes (openings) can be provided in the sheet (C) in a way that does not cover eyes, noses, etc., or cuts can be provided in a way that allows it to deform into a shape that follows a bend.

[0075] The sheet (C) can be manufactured by attaching (fixing) a water-soluble calcium salt to a sheet substrate. The method for attaching the water-soluble calcium salt is not particularly limited, and conventionally known methods can be used. For example, a method of coating a sheet substrate with a solution containing a water-soluble calcium salt and then drying it can be exemplified. The solution containing the water-soluble calcium salt is not particularly limited, and water or alcohol can be exemplified.

[0076] The carbon dioxide gas bag kit of this embodiment may consist only of the adhesive composition (A), carbon dioxide additive (B), and sheet (C) described above, or it may include other items besides these. For example, in addition to the adhesive composition (A), carbon dioxide additive (B), and sheet (C), the carbon dioxide gas sealing kit of this embodiment may also include a scraper (spreader) for mixing the adhesive composition (A) and the carbon dioxide additive (B).

[0077] Next, the method of using the carbon dioxide bag kit of this embodiment, which includes an adhesive composition (A), a carbon dioxide additive (B), and a sheet (C), will be described. The method of using the carbon dioxide bag kit of this embodiment includes at least three steps: a mixing step, a coating step, and a covering step.

[0078] The mixing process involves combining the viscous composition (A) with the carbon dioxide additive (B). By mixing the viscous composition (A) and the carbon dioxide additive (B), an external agent that generates carbon dioxide gas (carbon dioxide gas bag) is obtained. The mixing of the viscous composition (A) and the carbon dioxide additive (B) can be carried out in a way that the acid contained in the carbon dioxide additive (B) or substances that produce acid through hydrolysis are not predominantly present in the viscous composition (A) (a uniform mixing method), and there are no particular limitations on the mixing method.

[0079] When the carbon dioxide additive (B) contains an acid, during the mixing process, if the viscous composition (A) is mixed with the carbon dioxide additive (B), the acid in the carbon dioxide additive (B) reacts with the carbonate in the viscous composition (A) to produce carbon dioxide. Additionally, the acid in the carbon dioxide additive (B) also reacts with the water-insoluble calcium salt in the viscous composition (A) to produce calcium ions. These calcium ions then react with the gelling agent in the viscous composition (A) to undergo a gelation reaction.

[0080] Furthermore, if the carbon dioxide additive (B) contains a substance that hydrolyzes to produce acid, during the mixing process, if the viscous composition (A) is mixed with the carbon dioxide additive (B), the substance in the carbon dioxide additive (B) that hydrolyzes to produce acid reacts with the water contained in the viscous composition (A) to produce acid. Moreover, the produced acid reacts with the carbonate contained in the viscous composition (A) to produce carbon dioxide gas. Additionally, the produced acid also reacts with the water-insoluble calcium salt contained in the viscous composition (A) to produce calcium ions. The produced calcium ions react with the gelling agent contained in the viscous composition (A) to undergo a gelation reaction.

[0081] The coating process involves applying a mixture of the viscous composition (A) and the carbon dioxide auxiliary (B) (i.e., mixture (A)(B)) to the skin. The method of coating mixture (A)(B) is not particularly limited, but from the viewpoint that the generated carbon dioxide is more easily absorbed transdermally, it is preferable to coat mixture (A)(B) to the skin with a thickness of 0.2 mm to 50.0 mm. It should be noted that if mixture (A)(B) gels, carbon dioxide gas is difficult to absorb transdermally; therefore, the coating process is preferably performed immediately after the mixing process.

[0082] In the coating process, by applying mixture (A) and (B) to the skin, a portion of the carbon dioxide generated in mixture (A) and (B) is released from the contact surface with the skin. As a result, carbon dioxide gas can be absorbed through the skin.

[0083] The coating process is a process in which the sheet (C) is applied to the skin in a manner that brings the mixture (A) and (B) to contact with the skin. When the sheet (C) is applied to the skin, only the parts of the sheet (C) with water-soluble calcium salts attached need to come into contact with the mixture (A) and (B), and the entire surface of the sheet (C) may not need to come into contact with the mixture (A) and (B).

[0084] In the coating process, by bringing the sheet (C) into contact with the mixture (A) and (B) applied to the skin, the water-soluble calcium salts adhering to the sheet (C) dissolve in the water contained in the mixture (A) and (B), generating calcium ions. These calcium ions react with the gelling agent (a gelling agent that gels via calcium ions) contained in the mixture (A) and (B), promoting the gelation reaction that occurs in the mixture (A) and (B). This promotion of the gelation reaction occurs at the contact surface (and its periphery) of the sheet (C) with the adhering water-soluble calcium salts, so the contact surface (and its periphery) of the mixture (A) and (B) with the sheet (C) gels faster than the areas other than the contact surface (and its periphery) of the sheet (C) (hereinafter referred to as "other areas"). Therefore, the mixture (A) and (B) applied to the skin is less likely to drip.

[0085] Furthermore, the gelation reaction is promoted at the contact surface (and its periphery) with the sheet (C) in mixtures (A) and (B), so even if the contact surface (and its periphery) with the sheet (C) gels, other areas can remain viscous (flowable). Therefore, carbon dioxide gas is allowed to move towards the contact surface with the skin, thus allowing carbon dioxide to be released from the contact surface. Additionally, because the contact surface with the sheet (C) gels, the movement of carbon dioxide towards the contact surface with the sheet (C) is inhibited, thus increasing the amount of carbon dioxide towards the contact surface with the skin, and more carbon dioxide gas is easily released from the contact surface with the skin. As a result, the carbon dioxide gas generated in mixtures (A) and (B) can more effectively reach the skin.

[0086] From the viewpoint of suppressing the dripping of mixtures (A) and (B) earlier, or enabling the carbon dioxide gas generated in mixtures (A) and (B) to reach the skin more effectively, the coating process is preferably performed immediately after the coating process is completed. Furthermore, during the coating process, the sheet (C) coated with mixtures (A) and (B) can be peeled off from the mixtures (A) and (B) after gelation at the contact surface with the sheet (C).

[0087] The carbon dioxide gas bag kit of this embodiment can be used by the method described above, which includes a mixing process, a coating process, and a covering process. In addition to these processes, in order to absorb more carbon dioxide gas through the skin, it may also include a placement process in which the mixture (A) and (B) that generates carbon dioxide gas are placed on the skin for a specified period of time, and a removal process in which the gelled mixture (A) and (B) are removed from the skin after the mixture (A) and (B) have gelled as a whole.

[0088] The carbon dioxide gas encapsulation kit of this embodiment, as described above, can induce a first gelation (gelation of the contact surface with the sheet (C) and its periphery) and a second gelation (gelation of other areas) when coated on the skin in the mixture (A) and (B). Therefore, according to the carbon dioxide gas bag kit of this embodiment, the carbon dioxide gas bag (i.e., the mixture (A) and (B)) is less prone to dripping, and the carbon dioxide gas generated in the carbon dioxide gas bag (i.e., the mixture (A) and (B)) can effectively reach the skin.

[0089] Example

[0090] The present invention will be described in more detail below through embodiments, but the present invention is not limited to these embodiments.

[0091] (Adhesive Composition (A))

[0092] Prepare the components shown in Table 1 below, mix them to obtain viscous composition a. Use this as viscous composition (A).

[0093] [Table 1]

[0094] Adhesive composition a Content (mass%) Sodium bicarbonate (carbonate) 1.0 Calcium carbonate (a calcium salt that is sparingly soluble in water) 0.7 Cellulose gum (thickener) 1.2 Sodium alginate (thickener, gelling agent) 2.3 water 84.8 1,3-Butanediol 10.0 100 (Total)

[0095] (Carbon Dioxide Additive (B))

[0096] Prepare gluconolactone (particle size 10-500 μm) as carbon dioxide auxiliary agent b. Use carbon dioxide auxiliary agent b in an amount 9 times that of calcium carbonate contained in the viscous composition (A) as carbon dioxide auxiliary agent (B).

[0097] [Table 2]

[0098]

[0099] (Sheet (C))

[0100] Prepare a 20% by mass calcium chloride aqueous solution, spray it onto a nonwoven fabric sheet made of cotton (basis weight 40 g / m2) and allow it to dry, thereby obtaining nonwoven fabric sheets c1-c10 in Table 3 below with calcium chloride (solubility in water at 20°C and pH 7.0: 74.5 g / 100 mL). These nonwoven fabric sheets are used as sheet (C).

[0101] [Table 3]

[0102] Non-woven sheet c <![CDATA[Calcium chloride adhesion amount (g / m 2 )]]> c1 3.9 c2 8.0 c3 12.4 c4 17.0 c5 27.2 c6 38.6 c7 42.9 c8 47.2 c9 51.5 c10 55.8

[0103] [Examples and Comparative Examples]

[0104] The adhesive composition (A), carbon dioxide additive (B), and sheet (C) were combined as shown in Table 4 below to obtain the carbon dioxide gas bag kits of Examples 1-10 and Comparative Example 1. It should be noted that in Table 4 below, a represents the adhesive composition, b represents the carbon dioxide additive, and c1-c10 represent the nonwoven sheets c1-c10, respectively.

[0105] [Table 4]

[0106]

[0107] [Evaluation 1 (Gelization Confirmation Test on Outer Surfaces Other Than Skin Contact Surface)]

[0108] For the carbon dioxide bag kits of each embodiment and comparative example, a carbon dioxide additive (B) is added to the adhesive composition (A), and the adhesive composition (A) and carbon dioxide additive (B) are mixed. A measuring spoonful (about 5g) of the resulting mixture (A) and (B) is taken and applied to the skin. Regarding Example 1, after applying the mixture (A) and (B) to the skin, a sheet (C) is immediately placed over the mixture (A) and (B) in such a way that the sheet (C) is in contact with the mixture (A) and (B). On the other hand, for the comparative example, the mixture (A) and (B) are left in place after being applied to the skin.

[0109] It should be noted that, in order to ensure that the mixing time is consistent between the examples and comparative examples, the mixing of the adhesive composition (A) and the carbon dioxide additive (B) is set to 30 seconds from the time the carbon dioxide additive (B) is added to the adhesive composition (A). Furthermore, in order to ensure that the area of ​​the coating is consistent between the examples and comparative examples, mixtures (A) and (B) are applied to the same area on a pre-marked skin surface. It should be noted that the thickness of mixtures (A) and (B) applied to the skin is approximately 5 mm.

[0110] For each embodiment, after applying mixtures (A) and (B) to the skin for 3 minutes, the covering sheet (C) was peeled off from mixtures (A) and (B). Then, for each embodiment and comparative example, the outer surface (the side not in contact with the skin) of mixtures (A) and (B) was touched with a finger. If mixtures (A) and (B) remained attached to the finger even after the finger was released, it was judged as not gelled (evaluation: ×), and if mixtures (A) and (B) did not adhere to the finger, it was judged as gelled (evaluation: 〇). Furthermore, in cases where mixtures (A) and (B) did not adhere to the finger, if the thickness of the gelled portion was 0.5 mm or more, it was evaluated as ◎. The results are shown in Table 5.

[0111] [Evaluation 2 (Gelization Confirmation Test at Skin Contact Surface)]

[0112] Using the same method as in Evaluation 1, mixtures (A) and (B) were applied to the skin, and a sheet (C) was placed over them (the use of sheet (C) was only in Example 1). In Example 1, after applying mixtures (A) and (B) to the skin for 10 minutes, the sheet (C) was peeled off from the mixtures (A) and (B). Then, in both the Example and Comparative Examples, the surface portion of mixtures (A) and (B) applied to the skin was removed with a scraper, ensuring the thickness of the mixtures (A) and (B) applied to the skin was less than 2 mm. The mixtures (A) and (B) remaining on the skin were touched with a finger and separated. If the mixtures (A) and (B) adhered to the finger and did not separate, it was judged as not gelled (evaluation: ×), and if the mixtures (A) and (B) did not adhere to the finger, it was judged as gelled (evaluation: 〇). The results are shown in Table 2.

[0113] [Table 5]

[0114]

[0115] As shown in Table 2, in Examples 1-10, after 3 minutes of application to the skin, gelation occurred on the outer surface (the surface in contact with the sheet (C)) other than the surface in contact with the skin, but no gelation occurred on the surface in contact with the skin after 10 minutes. On the other hand, in Comparative Example 1, after 3 minutes of application to the skin, neither the outer surface (the surface in contact with the skin) nor the surface in contact with the skin of the mixtures (A) and (B) gelled. From these results, it can be understood that the carbon dioxide gas bag kits according to Examples 1-10 do not easily drip from the carbon dioxide gas bag (i.e., mixtures (A) and (B)) and allow the carbon dioxide gas generated in the carbon dioxide gas bag (i.e., mixtures (A) and (B)) to effectively reach the skin.

[0116] It should be noted that in both Example 1 and Comparative Example 1, it was confirmed that the mixture (A) and (B) gelled as a whole 30 minutes after being applied to the skin.

Claims

1. A kit for a carbon dioxide gas bag, characterized in that, It comprises an adhesive composition (A), a carbon dioxide additive (B), and a sheet (C). The viscous composition (A) comprises carbonate, thickener, water, gelling agent that gels via calcium ions, and calcium salt that is poorly soluble in water. The carbon dioxide additive (B) comprises at least one of an acid and a substance that produces an acid upon hydrolysis. The sheet (C) is coated with water-soluble calcium salts.

2. The carbon dioxide gas bag kit according to claim 1, wherein, The sheet (C) is a fiber sheet made of fibers.

3. The carbon dioxide gas bag kit according to claim 1, wherein, The amount of water-soluble calcium salt adhering to the sheet (C) is 1.0-100 g / m². 2 .

4. The kit for a carbon dioxide gas bag according to claim 1, wherein, The water-soluble calcium salt is a calcium salt with a solubility of more than 10.0 g / 100 ml in water at 20°C and pH 7.

0.

5. A sheet material (C), characterized in that, For contact with a mixture of viscous composition (A) and carbon dioxide additive (B), The viscous composition (A) comprises carbonate, thickener, water, gelling agent that gels via calcium ions, and calcium salt that is poorly soluble in water. The carbon dioxide additive (B) comprises at least one of an acid and a substance that produces an acid upon hydrolysis. The sheet (C) is coated with water-soluble calcium salts.

6. The sheet (C) according to claim 5, wherein it is a fiber sheet composed of fibers.

7. The sheet (C) according to claim 5, wherein, The amount of water-soluble calcium salt attached is 1.0-100 g / m³. 2 .

8. The sheet (C) according to claim 5, wherein the water-soluble calcium salt is a calcium salt with a solubility of more than 10.0 g / 100 ml in water at 20°C and pH 7.0.

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