Three-hemorrhoid-in-one hemorrhoid-preventing self-dissolving administration therapeutic patch capable of being used in broad-spectrum underpants

Abstract

The invention relates to a three-in-one hemorrhoid-preventing self-dissolving drug delivery treatment patch capable of being used in broad-spectrum underpants, and belongs to the technical field of medical care. The patch comprises a detachable adhesion layer, a temperature-sensitive slow-release layer and a core medicine layer, the core medicine layer is formed by compounding nanocarbon, marine active substances (algal polysaccharides and chitin), dragon's blood, borneol, gallnut, coptis chinensis and the like, and the targeting property is enhanced through a nanotechnology; and the temperature-sensitive slow-release layer adopts a compound of poly (N-isopropylacrylamide) (PNIPAM) and chitosan, and continuously releases drugs under the triggering of body temperature. The patch can be adhered to the crotch of a pair of underpants like a sanitary towel, can be self-dissolved for administration after being in contact with a focus, and is effective for internal and external hemorrhoids and mixed hemorrhoids. Clinical data show that the total effective rate reaches 95.8%, and no skin irritation is caused. The product integrates traditional Chinese medicines, nanotechnology and intelligent materials, and solves the problems of uncontrollable drug release and poor adaptability of the existing hemorrhoid patch.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of healthcare technology, in particular to a hemorrhoid treatment patch integrating nano-traditional Chinese medicine, temperature-sensitive material and detachable design, which is suitable for the prevention and treatment of internal hemorrhoids, external hemorrhoids and mixed hemorrhoids. BACKGROUND

[0002] The existing hemorrhoid treatment has the following problems: 1. Traditional suppositories / ointments (such as CN1810281A): manual administration is required, drug release is uncontrollable, and clothes are easily contaminated; 2. Fixed drug patch (such as CN109925367A): cannot adapt to different types of hemorrhoids, and has no temperature-sensitive trigger function; 3. Intelligent hemorrhoid pants (such as Zhizhi Zhizhi pants): focus on physical pressure, and the current trial product series still lacks drug and device collaborative design.

[0003] In addition, the application of marine active ingredients in existing products has not been reported except for the "Baina Zhikang" and "Haina Zhikang" series products of Tianjin Bainabiological Technology Co., Ltd., and seaweed polysaccharide and chitin have significant anti-inflammatory and tissue repair effects. SUMMARY

[0004] The present application proposes the following innovative solutions: 1. Core drug layer: improve drug penetration through nano-carrier, enhance antibacterial and anti-inflammatory effects by compounding marine active substances, and components comply with the hemorrhoid treatment principle recorded in "Compendium of Materia Medica" (such as blood stasis, astringency of gallnut); 2. Temperature-sensitive sustained-release layer: body temperature triggers self-dissolution to achieve continuous drug delivery; 3. Detachable design: similar to sanitary napkin attachment, suitable for any underpants. DETAILED DESCRIPTION

[0005] Example 1 - Patch Preparation: 1. Mix 6g of nano-carbon, 12g of seaweed polysaccharide, 10g of chitin, and other traditional Chinese medicine components, then super-micro powder them, and make an ointment with vaseline; 2. Dissolve PNIPAM and chitosan (ratio 7:3) in water, cross-link to form a temperature-sensitive gel layer; 3. Stack the detachable adhesive layer, temperature-sensitive sustained-release layer, and core drug layer in order, and cut into 40mm x 80mm patches.

[0006] Example 2 - Clinical Use: Attach the patch to the crotch of the underpants, and after contacting the anus, the temperature-sensitive layer liquefies, and the drug is continuously released for 6-8 hours, replaced daily. Clinical Trials

[0007] In Shanxi Tongwen Vocational and Technical College supporting cooperative resource hospital to carry out test: - Group: experimental group (this product) 100 cases, control group (traditional hemorrhoids suppository) 100 cases; - Results: experimental group 7 days pain relief rate 94% (control group 68%), 14 days cure rate 89% (control group 55%), no skin allergy. BRIEF DESCRIPTION OF DRAWINGS

[0008] Figures 1-3 The schematic diagram is to show the layered structure of the patch, pant adaptation and temperature-sensitive release process.

Claims

1. A three hemorrhoid in one anti-hemorrhoid self-dissolving adhesive treatment patch, characterized in that Comprise the following structures: - detachable adhesive layer (1): using medical pressure-sensitive adhesive, can be pasted in the crotch of underpants; - temperature-sensitive sustained-release layer (2): made of poly-N-isopropyl acrylamide (PNIPAM) and chitosan complex, the phase transition temperature is 32-36℃; - core drug layer (3): composed of the following components by weight percentage: nano-carbon 5-8%, alginate 10-15%, chitin 8-12%, dragon's blood 8-10%, borneol 6-8%, gallnut 5-7%, Coptis 4-6%, Cortex Phellodendri 4-6%, olibanum 5-7%, myrrh 5-7%, calamine 3-5%, copper vitriol 3-5%, aloe 15-20%.

2. The drug delivery treatment patch according to claim 1, characterized in that: - the marine active substance is sulfated polysaccharide extracted from deep-sea brown algae, with a molecular weight of 10-50kDa; - the nano-carbon is carboxylated multi-walled carbon nanotube with a particle size of 20-50nm.

3. The drug delivery treatment patch according to claim 1, characterized in that: - the temperature-sensitive sustained-release layer (2) liquefies under body temperature triggering, releasing the active ingredients in the core drug layer (3); - the detachable adhesive layer (1) has an adhesion force of 5-10N / 25mm to the underpants, and no residue is left when peeled off.

4. The drug delivery treatment patch according to claim 1, characterized in that: - the core drug layer (3) further comprises pH-responsive microcapsules (4) encapsulating hemostatic components (such as Yunnan Baiyao extract) inside.

5. A broad-spectrum underpants, characterized in that: - the crotch of the underpants is provided with a special pasting area, which is adapted to the drug delivery treatment patch of claims 1-4; - the pasting area is made of breathable and antibacterial fabric containing graphene blended fiber.

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