Composition with effects of tonifying kidney, strengthening essence and resisting oxidation as well as preparation method and application of composition

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a composition with the effects of tonifying kidney, strengthening essence and resisting oxidation as well as a preparation method and application thereof. According to the composition disclosed by the invention, the zinc-selenium composition, the compound yeast extract, the L-carnitine and the specific traditional Chinese medicine extract are combined in pairs, or three or four of the zinc-selenium composition, the compound yeast extract, the L-carnitine and the specific traditional Chinese medicine extract. Experiments show that the composition can generate a synergistic effect under a specific ratio, and the synergistic effect of four combinations is more obvious. The components of the composition are medicinal and edible components, and the composition has the effects of multiple antioxidation, kidney tonifying, essence strengthening and sperm motility improvement, is good in taste and high in compliance, and has a better effect on improving the symptoms of asthenospermia, insufficient sperm quantity, male function decline and sex hormone reduction.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a composition with the effects of tonifying kidney and benefiting essence and antioxidation, and a preparation method and application thereof. BACKGROUND

[0002] With the increasing work pressure and bad living habits, more and more male sperm activity is reduced, and oligoasthenospermia has become one of the common diseases of men in recent years, which seriously affects the fertility of patients and families. At present, for oligoasthenospermia, drug treatment is the most commonly used treatment, including specific treatment, non-specific treatment (empirical treatment) and traditional Chinese medicine treatment. For patients with clear causes, specific treatment has good effect; patients who cannot be clear about specific causes or pathogenesis can use non-specific treatment. Conventional western medicine such as levocarnitine and testosterone is often used in clinical treatment, and traditional Chinese medicine believes that oligospermia is mainly kidney deficiency type and is classified into the category of 'little essence', so the treatment should be mainly based on tonifying kidney and benefiting essence. However, the effect of western medicine treatment or traditional Chinese medicine treatment alone is poor for some patients, and the effect is single, so it is urgent to combine the treatment to improve the treatment effect. Therefore, it is particularly urgent to develop a functional food based on the basic concept of combination of western medicine and traditional Chinese medicine nutrition food therapy as an auxiliary treatment for oligoasthenospermia drug treatment, and improve the effect of drug treatment. SUMMARY

[0003] Therefore, the present application provides a composition with the effects of tonifying kidney and benefiting essence and antioxidation, and a preparation method and application thereof.

[0004] The composition provided by the present application is prepared from two or more than two kinds of components in the following weight parts:

[0005] The composition is prepared from at least two raw materials:

[0006]

[0007] The traditional Chinese medicine extract is prepared from the following raw materials in the following mass parts:

[0008] 5-15 parts of dried ginger, 5-15 parts of cassia, 50-250 parts of polygonatum.

[0009] The zinc-selenium composition is prepared from the following raw materials in the following mass parts:

[0010] 0.05-0.3 parts of zinc gluconate and 0.4-1 part of selenium-rich protein powder;

[0011] The compound yeast extract is prepared from the following raw materials in the following mass parts:

[0012] Yeast extract 0.5-3.5 parts, bamboo leaf flavone 0.1-2.5 parts, mussel polysaccharide 0.1-2.5 parts, kale extract 1-5 parts.

[0013] In the present application, the traditional Chinese medicine extract is composed of dried ginger, cassia and polygonatum. Each component is optimized by scientific matching and ratio, and each component is reasonably matched, which has excellent multiple antioxidant, kidney-tonifying and essence-nourishing effects to improve sperm motility. Among them, polygonatum is the monarch drug, dried ginger and cassia are the auxiliary drugs, polygonatum assists in nourishing yin at a small dose, and fills the meridians at a large dose, tonifies the spleen, and is used for improving the symptoms of food intake, fatigue, and solving yin deficiency and qi deficiency. Dried ginger and cassia are both hot drugs, and a small amount of yang-warming drugs can slightly stimulate yang qi, promote the transportation and absorption of yin-nourishing drugs such as polygonatum, and embody the theory of seeking yang in yang in traditional Chinese medicine. The reasonable matching of the three can achieve the effects of nourishing yin and tonifying qi, improving the symptoms of qi deficiency, and is beneficial to tonifying the kidney and essence, and improving sperm quality. On this basis, the traditional Chinese medicine extract can be used in combination with zinc selenium composition, compound yeast extract and L-carnitine to produce synergistic effect.

[0014] In the present application, the 25-45 parts of traditional Chinese medicine extract are prepared from 5-15 parts of dried ginger, 5-15 parts of cassia and 50-250 parts of polygonatum. Among them, the mass represented by "parts" in the same scene is the same.

[0015] In some embodiments, the composition is prepared from the following mass parts of raw materials:

[0016]

[0017] In some specific embodiments, the composition is prepared from the following mass parts of raw materials:

[0018] Compound yeast extract 6.5 parts, L-carnitine 2.5 parts, zinc selenium composition 0.85 parts, traditional Chinese medicine extract 35 parts. Among them, the 35 parts of traditional Chinese medicine extract are prepared by extracting 15 parts of dried ginger, 15 parts of cassia and 150 parts of polygonatum.

[0019] In the composition of the present application, the preparation method of the traditional Chinese medicine extract includes three methods, namely, percolation method, heating reflux extraction method and water decoction method, and the extracts prepared by the three methods all have good multiple antioxidant, kidney-tonifying and essence-nourishing effects to improve sperm motility.

[0020] Among them, the percolation method specifically includes: the polygonatum, cassia and dried ginger are wetted and soaked with 45%-85% ethanol water solution, and then percolated, the extract is concentrated, dried and pulverized to obtain the traditional Chinese medicine extract.

[0021] In this method, the volume fraction of ethanol in the aqueous ethanol solution is 75%. Preferably, the method includes: wetting Polygonatum sibiricum, cinnamon, and dried ginger with 1.5 times their mass of 75% ethanol aqueous solution for 30 minutes, then adding 75% ethanol aqueous solution until the herbs are completely submerged, soaking for 24 hours, and then performing percolation extraction at a rate of 1.5 ml / 1000g, using a total of 6 times the mass of the herbs in 75% ethanol. In this method, the collection of the percolate is divided into two parts: the first part collects the percolate equivalent to 85% of the mass of the herbs, and the second part is the remaining percolate. The second part of the percolate was concentrated under low temperature and reduced pressure at 50℃~65℃ and a vacuum degree of 0.07Mpa~0.08MPa to a relative density of 1.150~1.160. Then it was combined with the first part of the percolate and concentrated again under low temperature and reduced pressure at 50℃~65℃ and a vacuum degree of 0.07Mpa~0.08MPa to a relative density of 1.300 to obtain an extract. After drying and pulverizing, it was passed through a 100-mesh sieve to obtain the Chinese herbal extract.

[0022] The heating reflux extraction method specifically includes: extracting Polygonatum sibiricum, cinnamon, and dried ginger by reflux with 55%–85% ethanol aqueous solution, concentrating, drying, and pulverizing the extract, and then mixing it with donkey-hide gelatin peptide to obtain the Chinese herbal extract.

[0023] In this method, the mixed powders of Polygonatum sibiricum, cinnamon, and dried ginger are added to a container, 8 times the amount of 75% ethanol is added, and the mixture is refluxed for 3 hours. After filtration, the filtrate is concentrated under low temperature and reduced pressure at 50℃~65℃ and a vacuum degree of 0.07Mpa~0.08MPa to a relative density of 1.200~1.250. After drying, the extract is pulverized into a 100-mesh fine powder.

[0024] The water decoction extraction includes: extracting Polygonatum sibiricum, cinnamon and dried ginger by water decoction, and then filtering, concentrating, drying and pulverizing the extract to obtain the Chinese herbal extract.

[0025] In this method, the herbs are soaked in 9 times their weight of water for 24 hours before decoction. The decoction is performed twice. The first decoction uses 9 times the combined weight of the herbs (Polygonatum sibiricum, cinnamon, and dried ginger) and is decocted for 2 hours. The second decoction uses 6 times the combined weight of the herbs and is decocted for 1.5 hours. The decoctions are combined and concentrated under low-temperature reduced pressure at 65℃~75℃ and a vacuum of 0.07Mpa~0.08MPa to a relative density of 1.200~1.240. After drying and pulverizing, the extract is passed through a 100-mesh sieve to obtain the herbal extract.

[0026] The present application attempts to combine zinc selenium composition, composite yeast extract, L-carnitine and specific traditional Chinese medicine extract two by two, or three, or four together, and finds that the effect of each component combination is better than that of single use, and can produce significant synergistic effect under specific ratio.

[0027] The present application finds that the following combinations can produce synergistic effect, as follows:

[0028] Zinc selenium composition and composite yeast extract can produce synergistic effect at a ratio of 3:6.5.

[0029] Traditional Chinese medicine extract and L-carnitine combination can produce synergistic effect at a ratio of 35:2.5.

[0030] L-carnitine and zinc selenium composition combination can produce synergistic effect at a ratio of 2.5:0.85.

[0031] Zinc selenium composition and traditional Chinese medicine extract combination can produce synergistic effect at a ratio of 0.85:35.

[0032] Composite yeast extract and traditional Chinese medicine extract combination can produce synergistic effect at a ratio of 6.5:35.

[0033] Composite yeast extract and L-carnitine combination can produce synergistic effect at a ratio of 6.5:2.5.

[0034] Therefore, the present application provides a composition consisting of zinc selenium composition and composite yeast extract, traditional Chinese medicine extract and L-carnitine, L-carnitine and zinc selenium composition, zinc selenium composition and traditional Chinese medicine extract, composite yeast extract and traditional Chinese medicine extract, and composite yeast extract and L-carnitine.

[0035] Alternatively, the present application provides a composition consisting of any three of zinc selenium composition, L-carnitine, composite yeast extract and traditional Chinese medicine extract, for example, consisting of zinc selenium composition, L-carnitine and traditional Chinese medicine extract, or L-carnitine, composite yeast extract and traditional Chinese medicine extract, or zinc selenium composition, composite yeast extract and traditional Chinese medicine extract, or zinc selenium composition, L-carnitine, composite yeast extract.

[0036] Alternatively, the present application provides a composition consisting of zinc selenium composition, L-carnitine, composite yeast extract and traditional Chinese medicine extract.

[0037] In some specific embodiments, the composition consists of the following components by weight:

[0038]

[0039] In the present application, the traditional Chinese medicine extract is prepared from raw materials in the following mass ratio: Huangjing: Rougui: Ganjiang = 150:7.5:7.5, that is, 35 parts of traditional Chinese medicine extract is prepared from 15 parts of Ganjiang, 15 parts of Rougui and 150 parts of Huangjing by extraction.

[0040] In the zinc-selenium composition, the mass ratio of the raw material selenium-rich protein powder and zinc gluconate is 0.7:0.15.

[0041] In the composite yeast extract, the mass ratio of each raw material is: yeast extract: bamboo leaf flavone: clam polysaccharide: kale extract = 1.5:1:1:3.

[0042] Further, the present application provides the use of the composition as described above in the preparation of a product with multiple antioxidant, kidney-tonifying and essence-nourishing effects to improve sperm motility.

[0043] In the present application, the kidney-tonifying and essence-nourishing effects to improve sperm motility include improving male sperm motility or male sperm count, improving male sexual function decline and / or improving sexual hormone reduction.

[0044] Further, the present application also provides a product with multiple antioxidant, kidney-tonifying and essence-nourishing effects to improve sperm motility, comprising excipients and the composition as described above.

[0045] In the present application, the mass fraction of the composition as described above in the product with multiple antioxidant, kidney-tonifying and essence-nourishing effects to improve sperm motility is 25-75%, preferably 40-60%, further preferably 50-55%, and specifically can be 50%, 52.9%, 53.4% and the like.

[0046] In the present application, the product includes drugs, health products and health foods. The dosage form of the product described in the present application is tablet, capsule, granule, powder, oral liquid, soft capsule, pill, ointment, tea, wine, beverage, chewable tablet, buccal tablet, effervescent tablet, drop, syrup or powder.

[0047] In the present application, the excipients include but are not limited to at least one of sweeteners, flavoring agents and antioxidants. Other types of excipients can be appropriately added according to actual needs in the art.

[0048] As a preferred, the sweetener is selected from at least one of glucose, white sugar, sucralose, fructose, maltose, lactose, xylitol, sorbitol, maltitol, mannitol, erythritol, stevioside, mogroside, aspartame, acesulfame, neotame, alitame, isomaltulose, thaumatin or ammonium glycyrrhizinate.

[0049] As a preference, the flavoring agent is selected from at least one of cherry powder, orange powder, strawberry powder, lemon powder, apple powder, banana powder, instant coffee powder, blueberry powder or mint essence.

[0050] As a preference, the antioxidant is selected from at least one of natural or biosynthetic vitamin C and its derivatives, natural or synthetic vitamin E and its derivatives, beta-carotene and its derivatives, lycopene, astaxanthin microcapsule powder, lutein, coenzyme Q10, glutathione.

[0051] In some embodiments, the adjuvant includes sweeteners, flavoring agents, antioxidants. In specific embodiments, the adjuvant includes isomaltulose, cherry powder, instant coffee powder, vitamin C, natural vitamin E, astaxanthin microcapsule powder.

[0052] More specifically, the product is prepared from the following ingredients in the following amounts:

[0053] isomaltulose 25 parts, cherry powder 6 parts, yeast extract 1.5 parts, bamboo leaf flavonoids 1 part, mussel polysaccharide 1 part, kale extract 3 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, natural vitamin E 0.05 parts, zinc gluconate 0.15 parts, L-carnitine 2.5 parts, astaxanthin microcapsule powder 2 parts, selenium-rich protein powder 0.7 parts, dried ginger 15 parts, cassia 15 parts, and rhizoma polygonati 150 parts. Among them, the traditional Chinese medicine extract 35 parts is prepared from dried ginger 15 parts, cassia 15 parts, and rhizoma polygonati 150 parts. Therefore, the above formula can also be expressed as: isomaltulose 25 parts, cherry powder 6 parts, yeast extract 1.5 parts, bamboo leaf flavonoids 1 part, mussel polysaccharide 1 part, kale extract 3 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, natural vitamin E 0.05 parts, zinc gluconate 0.15 parts, L-carnitine 2.5 parts, astaxanthin microcapsule powder 2 parts, selenium-rich protein powder 0.7 parts, and traditional Chinese medicine extract 35 parts.

[0054] Further, the preparation method of the composition of the present application comprises:

[0055] S1, sieve the zinc gluconate and selenium-rich protein powder, mix well to obtain a zinc-selenium composition;

[0056] S2, mix the kale extract, yeast extract, bamboo leaf flavonoids, and mussel polysaccharide, sieve, and then mix with the traditional Chinese medicine extract;

[0057] S3, mix the antioxidant, flavoring agent, sweetener, and L-carnitine, sieve, and then mix with the zinc-selenium composition, the complex yeast extract, and the traditional Chinese medicine extract, granulate, and dry.

[0058] In steps S1-S3 of the present application, the sieving is through a 100-mesh sieve. The number of times of sieving is 2-4, specifically 2, 3 or 4 times.

[0059] In the present application, the drying comprises: sequentially drying the granules obtained in the granulation under non-heating and heating conditions. The time of non-heating drying is 15-20 minutes, specifically 15 minutes, 18 minutes or 20 minutes. The time of heating drying is 20-30 minutes, specifically 20 minutes, 25 minutes or 30 minutes.

[0060] In the present application, after the drying, there is further a step of drying the dried granules to a moisture content of ≤4.0%. In the present application, the temperature of drying is 75-80℃, specifically 75℃, 78℃ or 80℃. The time of drying is 1-2 hours.

[0061] In some embodiments of the present application, after the above drying, there is further a step of sieving and filling the dried granules. The sieving is through a 16-mesh sieve.

[0062] In some specific embodiments, the method for preparing the composition of the present application comprises the following steps:

[0063] The zinc gluconate and selenium-rich protein powder are sieved through a 100-mesh sieve for three times, and then mixed uniformly to obtain a zinc-selenium composition. The yeast extract, bamboo leaf flavone, mussel polysaccharide and kale extract are mixed, sieved through a 100-mesh sieve for three times, and then mixed uniformly. Then, the mixture is mixed with the traditional Chinese medicine extract, sieved through a 100-mesh sieve for three times, and then uniformly mixed for standby use.

[0064] The antioxidant, flavoring agent, sweetening agent and L-carnitine are mixed uniformly, sieved through a 100-mesh sieve for three times, and then mixed with the zinc-selenium composition, the compound yeast extract and the traditional Chinese medicine extract mixture in a high-speed mixing granulator to perform granulation. The granules are dried in a fluidized bed dryer for 15-20 minutes without heating, and then dried for 20-30 minutes with heating. Then, the granules are dried in a drying oven at 75-80℃ for 1-2 hours until the moisture content is ≤4.0%. Finally, the dried granules are sieved through a 16-mesh sieve and then filled.

[0065] Further, the present application further provides a method for multiple antioxidation, kidney-tonifying and essence-boosting and improving sperm activity, which comprises administering the composition or product as described above.

[0066] In the present application, the subject to be administered includes a human or a mammal, and the mammal includes a bovine, equine, ovine, porcine, canine, feline, rodent and primate.

[0067] The zinc selenium composition, the complex yeast extract, the L-carnitine and the specific traditional Chinese medicine extract are combined in pairs, or combined in three or four, and the synergistic effect can be produced under the specific ratio. The components of the composition are from the components for both medicine and food, have the effects of multiple antioxidant, kidney tonifying and essence benefiting and sperm activity improving, and good taste and high compliance, and have good effects on improving the symptoms of oligospermia, insufficient sperm, male function decline and sex hormone reduction. DETAILED DESCRIPTION

[0068] The application provides a composition with the effects of kidney tonifying and essence benefiting and antioxidation and a preparation method and application thereof, and those skilled in the art can refer to the content herein, and appropriately improve process parameters to realize. It is particularly pointed out that all similar replacements and changes are obvious to those skilled in the art, and they are regarded as being included in the application. The method and application of the application have been described through the preferred embodiments, and relevant personnel can obviously change or appropriately change and combine the method and application herein without departing from the content, spirit and scope of the application, to realize and apply the technical solution of the application.

[0069] The terms "comprise", "contain" and "have" are used interchangeably in this text, and are intended to mean the inclusivity of the scheme, meaning that the scheme can have other elements in addition to the listed elements. It should also be understood that the description using "comprise", "contain" and "have" in this text also provides a "consist of" scheme.

[0070] The numerical ranges and parameters involving in the application have been presented as precisely as possible in the specific embodiments. However, any numerical value inevitably contains a standard deviation caused by individual test methods in nature. Therefore, unless otherwise explicitly stated, it should be understood that all numerical ranges or specific data used in the disclosure can have a certain reasonable deviation within a certain range, for example: ±10%, ±5%, ±1% or ±0.5%.

[0071] Some cases are described in the examples and comparative examples of the application. Among them, the examples show some implementation manners of the application. However, this does not mean that the effect of the application can only be achieved in these cases. In fact, any concentration of each component between the two end point values shown in the examples can achieve good effect of relieving stomach pain, and the best cases are examples 10-12. In addition, many attempts have been made during the development process, such as using different ratios, extraction processes or extraction parameters, but the effects of these attempts are all inferior to the effects of examples 10-12, which will not be described here.

[0072] It should be understood that the size of the sequence number of the above processes in various embodiments of the present application does not mean the order of execution, and part or all of the steps can be executed in parallel or in sequence, and the execution order of the processes should be determined according to their functions and internal logic, and should not constitute any limitation on the implementation process of the embodiments of the present application.

[0073] The test materials used in the present application are all ordinary commercially available products and can be purchased in the market.

[0074] The present application will be further described below in conjunction with examples:

[0075] Example 1

[0076] The prescription is:

[0077] Isomalt 25 parts, needle cherry powder 6 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, astaxanthin microcapsule powder 2 parts, natural vitamin E 0.05 parts;

[0078] Compound yeast extract 6.5 parts (mass ratio of yeast extract, bamboo leaf flavone, conch polysaccharide, kale extract is 1.5:1:1:3), L-carnitine 2.5 parts.

[0079] The preparation method comprises the following steps:

[0080] The isomalt, needle cherry powder, instant coffee powder, vitamin C, natural vitamin E, astaxanthin microcapsule powder, compound yeast extract and L-carnitine are passed through a 100-mesh stainless steel sieve three times, mixed and granulated in a high-speed mixing granulator, the granules are dried in a boiling drying machine without heating for 15-20 minutes, heated and dried for 20-30 minutes, and then baked in a drying oven at 75-80℃ for 1-2 hours until the moisture content is ≤4.0%, and the dried granules are filled after passing through a 16-mesh sieve.

[0081] Example 2

[0082] The prescription is:

[0083] Isomalt 25 parts, needle cherry powder 6 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, astaxanthin microcapsule powder 2 parts, natural vitamin E 0.05 parts;

[0084] Huangji 150 parts, dried ginger 7.5 parts, cinnamon 7.5 parts;

[0085] Zinc selenium composition 0.85 parts (mass ratio of selenium-rich protein powder and zinc gluconate is 0.7:0.15).

[0086] The preparation method comprises the following steps:

[0087] Step 1 and step 2 are the same as those of comparative example 1,

[0088] Step 3: The isomaltulose, needle cherry powder, instant coffee powder, vitamin C, astaxanthin microcapsule powder, natural vitamin E, zinc-selenium composition, and traditional Chinese medicine extract are passed through a 100-mesh stainless steel sieve three times, mixed and granulated in a high-speed mixer, and then dried in a fluidized bed dryer for 15-20 minutes without heating, 20-30 minutes with heating, and 1-2 hours in a drying oven at 75-80°C until the moisture content is less than or equal to 4.0%. The dried granules are sieved through a 16-mesh sieve and then filled.

[0089] Example 3

[0090] The prescription is as follows:

[0091] Isomaltulose 25 parts, needle cherry powder 6 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, astaxanthin microcapsule powder 2 parts, and natural vitamin E 0.05 parts.

[0092] Zinc-selenium composition 0.85 parts (mass ratio of selenium-rich protein powder to zinc gluconate is 0.7:0.15), and compound yeast extract 6.5 parts (mass ratio of yeast extract, bamboo leaf flavone, conch polysaccharide, and kale extract is 1.5:1:1:3).

[0093] The preparation method comprises the following steps:

[0094] The isomaltulose, needle cherry powder, instant coffee powder, vitamin C, natural vitamin E, astaxanthin microcapsule powder, compound yeast extract, and zinc-selenium composition are passed through a 100-mesh stainless steel sieve three times, mixed and granulated in a high-speed mixer, and then dried in a fluidized bed dryer for 15-20 minutes without heating, 20-30 minutes with heating, and 1-2 hours in a drying oven at 75-80°C until the moisture content is less than or equal to 4.0%. The dried granules are sieved through a 16-mesh sieve and then filled.

[0095] Example 4

[0096] The prescription is as follows:

[0097] Isomaltulose 25 parts, needle cherry powder 6 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, astaxanthin microcapsule powder 2 parts, and natural vitamin E 0.05 parts.

[0098] Zinc-selenium composition 0.85 parts (mass ratio of selenium-rich protein powder to zinc gluconate is 0.7:0.15), and L-carnitine 2.5 parts.

[0099] The preparation method comprises the following steps:

[0100] The isomaltulose, needle cherry powder, instant coffee powder, vitamin C, astaxanthin microcapsule powder, natural vitamin E, zinc selenium composition, and L-carnitine are passed through a 100-mesh stainless steel sieve three times, mixed and granulated in a high-speed mixing granulator, the granules are dried in a fluidized bed dryer without heating for 15-20 minutes, heated for 20-30 minutes, and then dried in an oven at 75-80°C for 1-2 hours until the moisture content is ≤4.0%, the dried granules are passed through a 16-mesh sieve, and then filled.

[0101] Example 5

[0102] The prescription is as follows:

[0103] Isomaltulose 25 parts, needle cherry powder 6 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, astaxanthin microcapsule powder 2 parts, and natural vitamin E 0.05 parts.

[0104] Huangji 150 parts, dried ginger 7.5 parts, and cinnamon 7.5 parts.

[0105] Compound yeast extract 6.5 parts (mass ratio of yeast extract, bamboo leaf flavone, conch polysaccharide, and kale extract is 1.5:1:1:3).

[0106] The preparation method comprises the following steps:

[0107] Steps 1 and 2 are the same as those in Comparative Example 1,

[0108] Step 3: The isomaltulose, needle cherry powder, instant coffee powder, vitamin C, natural vitamin E, traditional Chinese medicine extract, astaxanthin microcapsule powder, and compound yeast extract are passed through a 100-mesh stainless steel sieve three times, mixed and granulated in a high-speed mixing granulator, the granules are dried in a fluidized bed dryer without heating for 15-20 minutes, heated for 20-30 minutes, and then dried in an oven at 75-80°C for 1-2 hours until the moisture content is ≤4.0%, the dried granules are passed through a 16-mesh sieve, and then filled.

[0109] Example 6

[0110] The prescription is as follows:

[0111] Isomaltulose 25 parts, needle cherry powder 6 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, astaxanthin microcapsule powder 2 parts, and natural vitamin E 0.05 parts.

[0112] Huangji 150 parts, dried ginger 7.5 parts, and cinnamon 7.5 parts.

[0113] L-carnitine 2.5 parts.

[0114] The preparation method comprises the following steps:

[0115] Steps 1 and 2 are the same as those in Comparative Example 1,

[0116] Step 3: The isomalt, needle leaf cherry powder, instant coffee powder, vitamin C astaxanthin microcapsule powder, natural vitamin E, L-carnitine, and traditional Chinese medicine extract are passed through a 100-mesh stainless steel sieve three times, mixed and granulated in a high-speed mixer, and the granules are dried in a fluidized bed dryer for 15-20 minutes without heating, dried for 20-30 minutes with heating, and then dried in an oven at 75-80°C for 1-2 hours until the moisture content is ≤4.0%. The dried granules are sieved through a 16-mesh sieve and then filled.

[0117] Example 7

[0118] Prescription:

[0119] Isomalt 25 parts, needle leaf cherry powder 6 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, astaxanthin microcapsule powder 2 parts, natural vitamin E 0.05 parts;

[0120] Huangji 150 parts, dried ginger 7.5 parts, cinnamon 7.5 parts;

[0121] L-carnitine 2.5 parts, zinc-selenium composition 0.85 parts (mass ratio of selenium-rich protein powder to zinc gluconate is 0.7:0.15).

[0122] The preparation method comprises the following steps:

[0123] Steps 1 and 2 are the same as those of Comparative Example 1,

[0124] Step 3: The isomalt, needle leaf cherry powder, instant coffee powder, vitamin C astaxanthin microcapsule powder, natural vitamin E, L-carnitine, and traditional Chinese medicine extract are passed through a 100-mesh stainless steel sieve three times, mixed and granulated in a high-speed mixer, and the granules are dried in a fluidized bed dryer for 15-20 minutes without heating, dried for 20-30 minutes with heating, and then dried in an oven at 75-80°C for 1-2 hours until the moisture content is ≤4.0%. The dried granules are sieved through a 16-mesh sieve and then filled.

[0125] Example 8

[0126] Prescription:

[0127] Isomalt 25 parts, needle leaf cherry powder 6 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, astaxanthin microcapsule powder 2 parts, natural vitamin E 0.05 parts;

[0128] Huangji 150 parts, dried ginger 7.5 parts, cinnamon 7.5 parts;

[0129] L-carnitine 2.5 parts, compound yeast extract 6.5 parts (mass ratio of yeast extract, bamboo leaf flavone, conch polysaccharide, and sylvestre extract is 1.5:1:1:3).

[0130] The preparation method comprises the following steps:

[0131] Step 1 and Step 2 are the same as those in Comparative Example 1,

[0132] Step 3: The isomaltulose, needle cherry powder, instant coffee powder, vitamin C, natural vitamin E, astaxanthin microcapsule powder, traditional Chinese medicine extract, L-carnitine, and compound yeast extract are passed through a 100-mesh stainless steel sieve three times, and then mixed and granulated in a high-speed mixer-granulator. The granules are dried in a fluidized bed dryer for 15-20 minutes without heating, dried for 20-30 minutes with heating, and then dried in an oven at 75-80°C for 1-2 hours until the moisture content is less than or equal to 4.0%. After the dried granules are passed through a 16-mesh sieve, they are filled.

[0133] Example 9

[0134] Prescription:

[0135] Isomaltulose 25 parts, needle cherry powder 6 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, astaxanthin microcapsule powder 2 parts, and natural vitamin E 0.05 parts;

[0136] Huangjing 150 parts, dried ginger 7.5 parts, and cinnamon 7.5 parts;

[0137] Zinc-selenium composition 0.85 parts (mass ratio of selenium-rich protein powder to zinc gluconate is 0.7:0.15), and compound yeast extract 6.5 parts (mass ratio of yeast extract, bamboo leaf flavone, conch polysaccharide, and kale extract is 1.5:1:1:3).

[0138] The preparation method comprises the following steps:

[0139] Step 1 and Step 2 are the same as those in Comparative Example 1,

[0140] Step 3: The isomaltulose, needle cherry powder, instant coffee powder, vitamin C, astaxanthin microcapsule powder, natural vitamin E, traditional Chinese medicine extract, zinc-selenium composition, and compound yeast extract are passed through a 100-mesh stainless steel sieve three times, and then mixed and granulated in a high-speed mixer-granulator. The granules are dried in a fluidized bed dryer for 15-20 minutes without heating, dried for 20-30 minutes with heating, and then dried in an oven at 75-80°C for 1-2 hours until the moisture content is less than or equal to 4.0%. After the dried granules are passed through a 16-mesh sieve, they are filled.

[0141] Example 10

[0142] Prescription:

[0143] Isomaltulose 25 parts, needle cherry powder 6 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, astaxanthin microcapsule powder 2 parts, and natural vitamin E 0.05 parts;

[0144] Huang- jing 150 parts, dried ginger 7.5 parts, cassia 7.5 parts;

[0145] Zinc selenium composition 0.85 parts (mass ratio of selenium-rich protein powder and zinc gluconate is 0.7:0.15), complex yeast extract 6.5 parts (mass ratio of yeast extract, bamboo leaf flavone, concha-pernicum polysaccharide and kale extract is 1.5:1:1:3), L-carnitine 2.5 parts.

[0146] The preparation method comprises the following steps:

[0147] Step 1: Huang- jing, dried ginger and cassia are mixed and then crushed by a high-speed crusher to obtain a mixed powder of Huang- jing, dried ginger and cassia.

[0148] Step 2: the mixed powder of Huang- jing, dried ginger and cassia is added into a container, 1.5 times of 75% ethanol aqueous solution is used to wet the mixed powder for 30 min, then 75% ethanol aqueous solution is added until the mixed powder is immersed, the mixed powder is soaked for 24 h, then the percolation extraction is carried out, the percolation speed is 1.5 ml / 1000 g, the total amount of 75% ethanol is 6 times of the amount of the mixed powder, the percolation liquid is collected in two parts, the first part is the percolation liquid corresponding to 85% of the amount of the mixed powder, and the second part is the remaining percolation liquid; the second part of the percolation liquid is concentrated under the conditions of 50-65 ℃ and 0.07-0.08 MPa to the relative density of 1.150-1.160, then the first part of the percolation liquid is combined with the second part, and the combined percolation liquid is concentrated again under the conditions of 50-65 ℃ and 0.07-0.08 MPa to the relative density of 1.300, the extract is dried and crushed to obtain the traditional Chinese medicine extract 100-mesh fine powder 35 parts.

[0149] Step 3: the isomaltulose, needle cherry powder, astaxanthin microcapsule powder, instant coffee powder, vitamin C, natural vitamin E, traditional Chinese medicine extract, zinc selenium composition, L-carnitine and complex yeast extract are passed through a 100-mesh stainless steel sieve for three times, then the mixture is granulated in a high-speed mixing granulator, the granules are dried in a fluidized bed dryer without heating for 15-20 min, dried with heating for 20-30 min, and then dried in a drying oven at 75-80 ℃ for 1-2 h until the moisture content is less than or equal to 4.0%, and finally the dried granules are filled into bottles after being passed through a 16-mesh sieve.

[0150] Example 11

[0151] The prescription is the same as that in Example 10:

[0152] Isomaltulose 25 parts, needle cherry powder 6 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, astaxanthin microcapsule powder 2 parts, natural vitamin E 0.05 parts;

[0153] Huang- jing 150 parts, dried ginger 7.5 parts, cassia 7.5 parts;

[0154] Zinc selenium composition 0.85 parts (mass ratio of selenium-rich protein powder and zinc gluconate is 0.7:0.15), complex yeast extract 6.5 parts (mass ratio of yeast extract, bamboo leaf flavone, mussel polysaccharide, kale extract is 1.5:1:1:3), L-carnitine 2.5 parts.

[0155] The preparation method comprises the following steps:

[0156] Step 1: mix the rhizoma polygonati, cassia bark and dried ginger, and then crush them with a high-speed crusher to obtain a mixed powder of cassia bark, dried ginger and rhizoma polygonati.

[0157] Step 2: add the mixed powder of rhizoma polygonati, cassia bark and dried ginger into a container, add 8 times of 75% ethanol, reflux extract for 3 hours, filter, and concentrate the filtrate to a relative density of 1.200-1.250 under the conditions of 50-65℃ and a vacuum degree of 0.07-0.08 MPa, and then dry and crush the concentrated filtrate into 100-mesh fine powder to obtain 35 parts of traditional Chinese medicine extract.

[0158] Step 3: pass the isomaltulose, needle leaf cherry powder, instant coffee powder, vitamin C, astaxanthin microcapsule powder, natural vitamin E, traditional Chinese medicine extract, L-carnitine, zinc selenium composition and complex yeast extract through a 100-mesh stainless steel sieve three times, mix and granulate them in a high-speed mixing granulator, dry the granules in a fluidized bed dryer without heating for 15-20 minutes, dry the granules in the fluidized bed dryer with heating for 20-30 minutes, and then dry the granules in a drying oven at 75-80℃ for 1-2 hours until the moisture content is less than or equal to 4.0%, and then fill the dried granules into containers after passing them through a 16-mesh sieve.

[0159] Example 12

[0160] The prescription is the same as that in Example 10:

[0161] Isomaltulose 25 parts, needle leaf cherry powder 6 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, astaxanthin microcapsule powder 2 parts, natural vitamin E 0.05 parts;

[0162] Rhizoma polygonati 150 parts, dried ginger 7.5 parts, cassia bark 7.5 parts;

[0163] Zinc selenium composition 0.85 parts, complex yeast extract 6.5 parts, L-carnitine 2.5 parts.

[0164] The preparation method comprises the following steps:

[0165] Step 1: Before decocting, the rhizoma polygonati, cinnamomum cassia bark and zingiber officinale are soaked in 9 times the mass of water for 24 hours. The decoction is performed twice. The first time, the mass of water is 9 times the mass of the rhizoma polygonati, cinnamomum cassia bark and zingiber officinale combined. The decoction is performed for 2 hours. The second time, the mass of water is 6 times the mass of the rhizoma polygonati, cinnamomum cassia bark and zingiber officinale combined. The decoction is performed for 1.5 hours. The decoctions are combined and concentrated to a relative density of 1.200-1.240 at 65-75°C and a vacuum of 0.07-0.08 MPa. The concentrate is dried, pulverized and passed through a 100-mesh screen to produce 35 parts of the extract of traditional Chinese medicine.

[0166] Step 2: The isomaltulose, needle cherry powder, astaxanthin microcapsule powder, instant coffee powder, vitamin C, natural vitamin E, extract of traditional Chinese medicine, L-carnitine, zinc-selenium composition and compound yeast extract are passed through a 100-mesh stainless steel screen three times and mixed and granulated in a high-speed mixer. The granules are dried in a fluidized bed dryer without heating for 15-20 minutes, with heating for 20-30 minutes and then in an oven at 75-80°C for 1-2 hours until the moisture content is ≤4.0%. The dried granules are passed through a 16-mesh screen and filled into containers.

[0167] Comparative Example 1

[0168] The prescription is:

[0169] Isomaltulose 25 parts, needle cherry powder 6 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, natural vitamin E 0.05 parts, astaxanthin microcapsule powder 2 parts.

[0170] Zingiber officinale 15 parts, cinnamomum cassia bark 15 parts, rhizoma polygonati 150 parts.

[0171] The preparation method comprises the following steps:

[0172] Step 1: The rhizoma polygonati, cinnamomum cassia bark and zingiber officinale are mixed and pulverized in a high-speed pulverizer to obtain a mixture of rhizoma polygonati, cinnamomum cassia bark and zingiber officinale powder.

[0173] Step 2: Add the mixed powders of Polygonatum sibiricum, dried ginger, and cinnamon to a container, moisten with 1.5 times their weight of 75% ethanol aqueous solution for 30 minutes, then add 75% ethanol aqueous solution until the herbs are completely submerged. After soaking for 24 hours, perform percolation extraction at a rate of 1.5 ml / 1000g, using a total of 6 times the weight of the herbs in 75% ethanol. The percolate is collected in two parts: the first part is the percolate equivalent to 85% of the weight of the herbs, and the second part is the remaining percolate. The second part of the percolate is concentrated under low-temperature reduced pressure at 50℃~65℃ and a vacuum of 0.07Mpa~0.08MPa to a relative density of 1.150~1.160. Then, it is combined with the first part of the percolate and concentrated again under low-temperature reduced pressure at 50℃~65℃ and a vacuum of 0.07Mpa~0.08MPa to a relative density of 1.300 to obtain an extract. After drying and pulverizing, 35 parts of the 100-mesh fine powder of the herbal extract are obtained.

[0174] Step 3: The isomaltulose, acerola cherry powder, instant coffee powder, vitamin C, astaxanthin microcapsule powder, and natural vitamin E are passed through a 100-mesh stainless steel sieve three times and mixed evenly. Then, fine powders of traditional Chinese medicine extracts obtained from Polygonatum sibiricum, cinnamon, and dried ginger are added. The mixture is then placed in a high-speed mixing granulator for granulation. The granules are dried in a fluidized bed dryer without heating for 15-20 minutes, then heated and dried for 20-30 minutes. Finally, they are dried in a drying oven at 75-80℃ for 1-2 hours until the moisture content is ≤4.0%. The dried granules are then passed through a 16-mesh sieve and packaged.

[0175] Comparative Example 2

[0176] The prescription is:

[0177] 25 parts isomaltulose, 6 parts acerola cherry powder, 6.5 parts instant coffee powder, 2 parts astaxanthin microcapsule powder, 0.35 parts vitamin C, and 0.05 parts natural vitamin E;

[0178] 6.5 parts of compound yeast extract (the mass ratio of yeast extract, bamboo leaf flavonoids, mussel polysaccharide, and kale extract was 1.5:1:1:3).

[0179] The preparation method includes the following steps:

[0180] The isomaltulose, acerola cherry powder, instant coffee powder, vitamin C, natural vitamin E, astaxanthin microcapsule powder, and compound yeast extract are passed through a 100-mesh stainless steel sieve three times, mixed and granulated in a high-speed mixing granulator, and the granules are dried in a fluidized bed dryer without heating for 15-20 minutes, then heated and dried for 20-30 minutes, and then dried in a drying oven at 75-80℃ for 1-2 hours until the moisture content is ≤4.0%. The dried granules are then passed through a 16-mesh sieve and packaged.

[0181] Comparative Example 3

[0182] The prescription is as follows:

[0183] Isomalt 25 parts, acerola cherry powder 6 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, astaxanthin microcapsule powder 2 parts, natural vitamin E 0.05 parts;

[0184] L-carnitine 2.5 parts.

[0185] The preparation method comprises the following steps:

[0186] The isomalt, acerola cherry powder, instant coffee powder, vitamin C, astaxanthin microcapsule powder, natural vitamin E and L-carnitine are sieved through a 100-mesh stainless steel screen three times, mixed and granulated in a high-speed mixing granulator, the granules are dried in a fluidized bed dryer for 15-20 minutes without heating, dried for 20-30 minutes with heating, and then dried in a drying oven at 75-80°C for 1-2 hours until the moisture content is less than or equal to 4.0%, and the dried granules are sieved through a 16-mesh screen and then filled.

[0187] Comparative Example 4

[0188] The prescription is as follows:

[0189] Isomalt 25 parts, acerola cherry powder 6 parts, instant coffee powder 6.5 parts, vitamin C 0.35 parts, astaxanthin microcapsule powder 2 parts, natural vitamin E 0.05 parts;

[0190] Zinc-selenium composition 0.85 parts (the mass ratio of selenium-rich protein powder to zinc gluconate is 0.7:0.15).

[0191] The preparation method comprises the following steps:

[0192] The isomalt, acerola cherry powder, instant coffee powder, vitamin C, astaxanthin microcapsule powder, natural vitamin E and L-carnitine are sieved through a 100-mesh stainless steel screen three times, mixed and granulated in a high-speed mixing granulator, the granules are dried in a fluidized bed dryer for 15-20 minutes without heating, dried for 20-30 minutes with heating, and then dried in a drying oven at 75-80°C for 1-2 hours until the moisture content is less than or equal to 4.0%, and the dried granules are sieved through a 16-mesh screen and then filled.

[0193] Verification of efficacy

[0194] The composition described in the foregoing examples or comparative examples is verified for efficacy in two parts of animal experiments and human experiments:

[0195] I. Animal experiments

[0196] 1. Experimental animals:

[0197] Kunming male rats are used for verification, and the rats are randomly divided into groups, with 15 rats in each group.

[0198] Model animal preparation: Kunming male rats were divided into normal group and model group by random number table method. Except for the normal group, the rats in the other groups were given reference literature method of pouring leigongtengdujia tablets 20 mg / (kg·d) for 5 weeks, to establish asthenospermia model.

[0199] 2. Experimental grouping:

[0200] After the success of modeling, the model group was given products of examples 1-12 and comparative examples 1-4. One bag of product was dissolved with 60 ml of warm water, and the weight was determined every day and given 1 ml / 100 g·d) by gavage, twice a day, for a total of 5 weeks. The normal group and the model group were normally fed.

[0201] 3. Experimental results:

[0202] The sperm density and sperm motility of each group of mice were detected:

[0203] Table 1 Zinc selenium composition and L-carnitine

[0204]

[0205] Table 2 Compound yeast extract and traditional Chinese medicine group

[0206]

[0207] Table 3 Zinc selenium composition and traditional Chinese medicine group

[0208]

[0209] Table 4 Compound yeast extract and L-carnitine

[0210]

[0211] Table 5 L-carnitine and traditional Chinese medicine group

[0212]

[0213] Table 6 Zinc selenium composition and compound yeast extract

[0214]

[0215] Table 7 Example 10 and example 3 / 6 group

[0216]

[0217] Note: The level in the table shows improvement after use.

[0218] The results show that each group of test objects can restore sperm parameters to different degrees. Among them, the product group of example 10 has the best effect.

[0219] 4. Evaluate the interaction effect between subjects:

[0220] According to the article "Evaluation of Drug Combination Effect Research Methods" by Guo Jianyou, Huo Haier and Jiang Tingliang, the evaluation methods of drug combination include simple algebra and addition method, isobologram method evaluation, etc. The present application uses simple algebra and addition method for evaluation as follows:

[0221] Simple algebra and addition method: E A+B = E A + E B

[0222] Wherein, E A is the utility of drug A produced by single use at a dose, E B is the utility of drug B produced by single use at a dose. When A drug and B drug are used in combination at the dose of single use respectively, the combined effect is the algebraic sum of the individual effects. After transformation, the formula for judging the combination effect is q = (E A+B -E A ) / EB but E A = E B , so that E A , E B are not interchanged, and the q value changes greatly. The meaning of q value is: q = 1 is additive effect, q > 1 is synergistic effect, and q < 1 is antagonistic effect.

[0223] Table 8

[0224]

[0225]

[0226] The experimental results show that each component in the composition provided by the present application is indispensable and jointly plays a good synergistic effect. And it has been verified that no matter how the groups are divided, the q value of each group can be greater than 1, showing synergistic effect. Among them, the q value of the product of example 10 is greater than 1.2, and the synergistic effect is more obvious than other groups.

[0227] II. Human experiment

[0228] Selected candidates must meet the Western medical diagnostic criteria for male infertility, be classified as mild to moderate oligospermia, asthenospermia, or non-severe teratospermia, and meet the TCM syndrome differentiation criteria for kidney essence deficiency. Candidates must be between 22 and 45 years old, have two consecutive abnormal semen analysis results, and have not received similar drug treatments or other therapies within half a month prior to participation. Candidates whose partners have infertility or are taking medications affecting sperm quality must be excluded. Congenital malformations, obstruction of the vas deferens, testicular atrophy, severe cardiovascular or cerebrovascular diseases, liver or kidney dysfunction, hematopoietic system diseases, mental illness, allergies, or allergies to multiple drugs are also excluded.

[0229] 420 eligible males were selected as subjects. The subjects were randomly divided into 7 groups of 60 each:

[0230] Experimental groups 7-12 took the samples from Examples 7-12, three times a day, one sachet each time, and their semen parameters were measured after 75 days.

[0231] The control group took Wuzi Yanzong Wan three times a day, 9g each time, for 75 consecutive days, and their semen parameters were measured. The main effects of Wuzi Yanzong Wan are: impotence, infertility, seminal emission, premature ejaculation, lower back pain, and dribbling after urination caused by kidney deficiency and essence depletion. Its ingredients include: wolfberry and dodder seed, which tonify kidney essence, strengthen yang, and boost spirits; raspberry, which nourishes true yin, strengthens the essence gate, and treats impotence; schisandra fruit, which tonifies kidney water, benefits lung qi, and stops seminal emission; and plantain seed, which promotes urination. Combined with the above four seeds, it tonifies while simultaneously purging, providing nourishment without being cloying.

[0232] The changes in semen parameters in the subjects were statistically analyzed. The results are shown in the table below:

[0233] Table 9. Changes in sperm parameters (Units: semen volume (ml), sperm density (millions / ml), grade a (a+b): %)

[0234]

[0235] Experimental results show that the compositions provided in each embodiment of the present invention have good effects of multiple antioxidants, tonifying the kidneys and replenishing essence, and improving sperm motility.

[0236] The above are merely preferred embodiments of the present invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A composition, characterized in that, It is made from at least two of the following raw materials in parts by weight: The herbal extract is prepared from the following raw materials in parts by weight: 5 to 15 parts dried ginger, 5 to 15 parts cinnamon, 50 to 250 parts polygonatum; The zinc-selenium composition is prepared from the following raw materials in parts by weight: Zinc gluconate 0.05–0.3 parts, selenium-enriched protein powder 0.4–1 part; The compound yeast extract is prepared from the following raw materials in parts by weight: Yeast extract 0.5–3.5 parts, bamboo leaf flavonoids 0.1–2.5 parts, clam polysaccharide 0.1–2.5 parts, and kale extract 1–5 parts.

2. The composition according to claim 1, characterized in that, The composition is prepared from the following raw materials in parts by weight: Preferably, the composition is prepared from the following raw materials in parts by weight: The compound yeast extract contains 6.5 parts, L-carnitine contains 2.5 parts, zinc-selenium composition contains 0.85 parts, and traditional Chinese medicine extract contains 35 parts.

3. The composition according to any one of claims 1 to 2, characterized in that, In the preparation of the traditional Chinese medicine extract, the mass ratio of Polygonatum sibiricum, cinnamon and dried ginger is 150:15:

15. And / or, in the zinc-selenium composition, the mass ratio of selenium-enriched protein powder to zinc gluconate is 0.7:0.15; And / or, in the compound yeast extract, the mass ratio of yeast extract, bamboo leaf flavonoids, mussel polysaccharide and kale extract is 1.5:1:1:

3.

4. The composition according to any one of claims 1 to 3, characterized in that, The preparation method of the traditional Chinese medicine extract includes: Dried ginger, cinnamon, and polygonatum were moistened and soaked in a 55%–85% ethanol aqueous solution, and then percolated. The extract was concentrated, dried, and pulverized to obtain the Chinese herbal extract. Alternatively, dried ginger, cinnamon, and polygonatum can be extracted by reflux with a 55%–85% ethanol aqueous solution, and the extract can be concentrated, dried, and pulverized to obtain the Chinese herbal extract. Alternatively, dried ginger, cinnamon, and polygonatum can be decocted in water to extract the herbal extract. The extract is then filtered, concentrated, dried, and pulverized to obtain the herbal extract.

5. Use of the composition according to any one of claims 1 to 4 in the preparation of antioxidant products.

6. The application according to claim 5, characterized in that, The kidney-tonifying and sperm-boosting effects include improving sperm motility, increasing sperm count, improving male sexual dysfunction, and / or increasing sex hormone secretion.

7. A product with antioxidant and kidney-tonifying effects, characterized in that, The product comprises the composition and excipients according to any one of claims 1 to 4; preferably, the composition accounts for 25% to 75% of the product by mass.

8. The product according to claim 7, characterized in that, The excipients include at least one of sweeteners, flavoring agents, and antioxidants; The sweetener is selected from at least one of glucose, white sugar, sucralose, fructose, maltose, lactose, xylitol, sorbitol, maltitol, mannitol, erythritol, steviol glycosides, mogrosides, aspartame, acesulfame potassium, neotame, alitame, isomaltulose, sematose, or ammonium glycyrrhizate; The flavoring agent is selected from at least one of acerola cherry powder, sweet orange powder, strawberry powder, lemon powder, apple powder, banana powder, instant coffee powder, blueberry powder, or mint flavoring; The antioxidant is selected from at least one of natural or biosynthetic vitamin C and its derivatives, natural or synthetic vitamin E and its derivatives, β-carotene and its derivatives, lycopene, astaxanthin microcapsule powder, lutein, coenzyme Q10, and glutathione.

9. The product according to any one of claims 7 to 8, characterized in that, It is made from the following parts by weight of raw materials: 25 parts isomaltulose, 6 parts acerola cherry powder, 1.5 parts yeast extract, 1 part bamboo leaf flavonoids, 1 part mussel polysaccharide, 3 parts kale extract, 6.5 parts instant coffee powder, 0.35 parts vitamin C, 0.05 parts natural vitamin E, 0.15 parts zinc gluconate, 2.5 parts L-carnitine, 2 parts astaxanthin microcapsule powder, 0.7 parts selenium-enriched protein powder, 15 parts dried ginger, 15 parts cinnamon, and 150 parts polygonatum.

10. A method for preparing the product according to any one of claims 7 to 9, comprising: S1. Sift zinc gluconate and selenium-enriched protein powder, mix well, and obtain a zinc-selenium composition. S2. Mix and sieve the kale extract, yeast extract, bamboo leaf flavonoids, and clam polysaccharide, and then mix with the traditional Chinese medicine extract. S3. After mixing and sieving the antioxidant, flavoring agent, sweetener and L-carnitine, mix them with the zinc-selenium composition, compound yeast extract and traditional Chinese medicine extract, granulate and dry.

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