Cream formula based on qi and blood tonifying and heart and kidney dredging and regulating and preparation method

Abstract

The invention relates to an ointment formula based on qi and blood tonifying and heart and kidney dredging and regulating and a preparation method, and belongs to the technical field of traditional Chinese medicine, the ointment is prepared from ginseng, astragalus membranaceus, five-prepared rehmannia glutinosa, Chinese yam, poria cocos, deer-horn glue, tortoise plastron, donkey-hide gelatin, dogwood, fructus lycii, semen cuscutae and other medicinal materials according to a specific ratio. The preparation method comprises the following steps: grinding part of the medicinal materials into powder, decocting the prepared rhizome of rehmannia firstly, decocting a plurality of sub-medicinal materials together, melting the glue medicinal materials by heat, mixing with other medicinal material decoctions, and concentrating to obtain the ointment. Through the synergistic effect of the medicinal materials, the comprehensive effects of reinforcing qi and nourishing yin, warming yang and promoting diuresis, tonifying kidney and replenishing essence and promoting circulation of heart and kidney are achieved, and the traditional Chinese medicine composition has the advantages of being comprehensive in curative effect, small in side effect and sufficient in component retention for consumptive disease, premature senility, chronic heart failure and arrhythmia caused by deficiency of qi and blood, yang deficiency and water flooding and heart and kidney disharmony.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, specifically to a paste formula and preparation method based on the dual replenishment of qi and blood and the regulation of the heart and kidneys. Background Technology

[0002] In Traditional Chinese Medicine (TCM) theory, the relationship between the heart and kidneys is crucial. Heart fire descends to warm kidney water, while kidney water ascends to nourish heart yin. Only when these two elements are in balance can normal bodily functions be maintained. If kidney essence is deficient and kidney water is insufficient, it cannot nourish heart fire, leading to excessive heart fire. Simultaneously, kidney yang deficiency impairs the transformation of fluids, easily causing water retention and dampness that ascends to the heart. This core pathogenesis of "heart-kidney disharmony" often manifests as complex clinical symptoms of qi and blood deficiency and yang deficiency with water retention, such as palpitations, shortness of breath, edema of the limbs, weakness in the lower back and knees, aversion to cold coexisting with night sweats, memory loss, premature graying of hair, loose teeth, and weak bones. These symptoms are commonly seen in modern medicine in chronic heart failure, arrhythmias, and various premature aging diseases.

[0003] Currently, clinical treatment for such complex syndromes often employs a combination of traditional Chinese and Western medicine, or the formulation of traditional Chinese medicine prescriptions. However, existing technologies have the following significant limitations:

[0004] First, treatments are often singular and fail to address the complex mechanisms of disease. Most existing traditional Chinese medicine preparations focus on a single effect. For example, Liuwei Dihuang Wan excels at nourishing Yin and tonifying the kidneys, but is less effective for Qi deficiency and water retention; Shengmai Yin is good at replenishing Qi and nourishing Yin, but lacks the ability to warm Yang, promote diuresis, and replenish essence and blood; Jinkui Shenqi Wan is more focused on warming and tonifying kidney Yang, but its Yin-nourishing and heat-clearing effects are relatively weak. Furthermore, these formulas lack specificity in "harmonizing the heart and kidneys." In clinical practice, to achieve a comprehensive approach, multiple drugs are often used in combination, which not only increases the patient's medication burden but also raises questions about drug interactions.

[0005] Secondly, the selection of medicinal materials and the processing techniques are not sophisticated enough, affecting efficacy and safety. Rehmannia glutinosa is a core herb for nourishing yin and blood, but its nature is rich and cloying; large doses or long-term use can easily impair the spleen and stomach, leading to side effects such as abdominal distension and loss of appetite, severely impacting patient compliance. Current techniques often use a single processing method for Rehmannia glutinosa, or fail to adequately address this issue, thus limiting the long-term application of the formula.

[0006] Third, the preparation process is crude, resulting in significant loss of active ingredients. In traditional preparations of medicinal pastes or decoctions, if all herbs are decocted together, it's impossible to consider the optimal decoction time for each herb, potentially leading to insufficient extraction or destruction of some active ingredients. This is especially true for animal-derived gelatinous materials such as donkey-hide gelatin and deer antler gelatin; if directly decocted with other herbs, they are highly susceptible to gelatinization and charring due to adhesion of dregs and uneven heating, resulting in substantial waste and loss of efficacy.

[0007] Therefore, there is an urgent need in this field for a traditional Chinese medicine compound preparation that can take into account all aspects, regulate the heart and kidneys, replenish qi, blood, yin and yang, and has few side effects and retains the active ingredients to overcome the shortcomings of the above-mentioned existing technologies. Summary of the Invention

[0008] In order to solve the problems of the prior art, this invention provides a paste formula and preparation method based on replenishing both qi and blood and regulating the heart and kidneys.

[0009] To solve the above-mentioned technical problems, the present invention is achieved through the following technical solution: Firstly, based on a formula for a paste that nourishes both Qi and blood and regulates the heart and kidneys, it is made from the following raw materials in parts by weight: 25-35 parts of yam, 25-35 parts of Poria cocos, 5-7 parts of ginseng, 120-180 parts of Rehmannia glutinosa, 8-12 parts of mulberry fruit, 8-12 parts of wolfberry fruit, 25-35 parts of plantain seed, 5-7 parts of Schisandra chinensis, and 25 parts of Cuscuta chinensis. -35 parts, Ligustrum lucidum 25-35 parts, Arctium lappa 35-45 parts, Deer antler glue 8-10 parts, Tortoise plastron 8-10 parts, Donkey-hide gelatin 5-7 parts, Astragalus membranaceus 25-35 parts, Cistanche deserticola 25-35 parts, Cornus officinalis 25-35 parts, Paeonia suffruticosa 5-7 parts, Cibotium barometz 8-10 parts, Achyranthes bidentata 25-35 parts, Eucommia ulmoides (fried) 8-10 parts, Angelica sinensis 8-10 parts, Prepared turtle shell 13-17 parts, Asparagus cochinchinensis 13-17 parts.

[0010] In one specific embodiment of the first aspect, the prepared Rehmannia glutinosa is processed Rehmannia glutinosa, wherein the processing method includes at least one of the following: processed with Amomum villosum, processed with ginger, processed with salt, processed with milk, and processed with wine.

[0011] In one specific embodiment of the first aspect, the weight parts of each raw material are as follows: 30 parts of yam, 30 parts of poria cocos, 6 parts of ginseng, 150 parts of prepared rehmannia root, 10 parts of mulberry fruit, 10 parts of wolfberry fruit, 30 parts of plantain seed, 6 parts of schisandra fruit, 30 parts of dodder seed, 30 parts of privet fruit, 39 parts of burdock seed, 9 parts of deer antler glue, 9 parts of tortoise shell, 6 parts of donkey-hide gelatin, 30 parts of astragalus root, 30 parts of cistanche deserticola, 30 parts of cornus officinalis, 6 parts of peony bark, 9 parts of cibotium barometz, 30 parts of achyranthes bidentata, 9 parts of stir-fried eucommia bark, 9 parts of angelica sinensis, 15 parts of prepared turtle shell, and 15 parts of asparagus root.

[0012] Secondly, the preparation method of the herbal paste formula based on replenishing both qi and blood and regulating the heart and kidneys includes the following steps:

[0013] S1: Grind the yam, poria cocos, and ginseng into a fine powder and set aside;

[0014] S2: Boil Rehmannia glutinosa in water for 1.5 hours, filter out the decoction, squeeze the juice from the dregs, and combine the decoctions;

[0015] S3: Boil mulberry fruit, wolfberry fruit, plantain seed, schisandra fruit, dodder seed, privet fruit, and burdock fruit in water for 1 hour, then filter out the decoction;

[0016] S4: Melt the deer antler glue, tortoise shell and donkey-hide gelatin to obtain a melted liquid;

[0017] S5: Add water to decoct Astragalus membranaceus, Cistanche deserticola, Cornus officinalis, Paeonia suffruticosa, Cibotium barometz, Achyranthes bidentata, stir-fried Eucommia ulmoides, Angelica sinensis, prepared turtle shell, and Asparagus cochinchinensis. Add the decoction obtained in steps S2 and S3, as well as the melted liquid obtained in step S4, and concentrate to form a paste.

[0018] S6: Add the fine powder obtained in step S1 and mix well to obtain the ointment.

[0019] In a specific embodiment of the second aspect, the Rehmannia glutinosa mentioned in step S2 is a five-processed Rehmannia glutinosa, including Rehmannia glutinosa processed with Amomum villosum, Rehmannia glutinosa processed with ginger, Rehmannia glutinosa processed with salt, Rehmannia glutinosa processed with milk, and Rehmannia glutinosa processed with wine.

[0020] Thirdly, the use of herbal paste formulas based on replenishing both qi and blood and regulating the heart and kidneys in the preparation of medicines for treating weakness or premature aging caused by deficiency of qi and blood, yang deficiency with water retention, and disharmony between the heart and kidneys.

[0021] In one specific implementation of the third aspect, symptoms of general debility or premature aging include palpitations and shortness of breath, edema of the limbs, sweating easily, soreness and weakness of the lower back and knees, memory decline, premature graying and loss of hair, loose teeth and weak bones, aversion to cold or night sweats.

[0022] Fourthly, the use of a traditional Chinese medicine formula based on replenishing both Qi and blood and regulating the heart and kidneys in the preparation of drugs for treating chronic heart failure or arrhythmia caused by deficiency of both Qi and Yin.

[0023] The beneficial effects of this invention are as follows:

[0024] 1. This invention organically integrates medicinal materials with various functions, including invigorating qi and strengthening the body, nourishing yin and replenishing essence, warming yang and promoting diuresis, tonifying the kidneys and strengthening the waist, and nourishing blood and calming the mind, to form a scientifically rigorous compound system. This formula is not simply a collection of ingredients, but rather aims to systematically regulate the complex pathogenesis of "qi and blood deficiency, yang deficiency with water retention, and disharmony between the heart and kidneys." Compared with traditional formulas with single functions, this invention exhibits a significant synergistic effect, simultaneously and effectively improving multiple symptoms such as palpitations, shortness of breath, edema, weakness in the lower back and knees, and aversion to cold and heat, thus solving the technical problem of the limited treatment scope and inability to address complex syndromes with single formulas.

[0025] 2. This invention employs a unique method of processing the core medicinal herb, Rehmannia glutinosa, using multiple excipients in a combined process. This distinctive treatment effectively counteracts its rich and cloying properties, fundamentally reducing the potential gastrointestinal discomfort associated with traditional Rehmannia glutinosa preparation, and significantly improving patient compliance and the safety of long-term use. Furthermore, this invention utilizes a refined preparation process of "step-by-step decoction" and "melting and mixing in." This process fully considers the physicochemical properties of different medicinal materials, maximizing the extraction and retention of various active ingredients while avoiding damage and loss of effective components, thus ensuring the stability and high efficacy of the final product.

[0026] 3. The ointment prepared in this invention has a clear therapeutic effect, especially showing unique advantages for modern refractory diseases such as chronic heart failure and arrhythmia caused by deficiency of both Qi and Yin. It can effectively relieve clinical symptoms and enhance the patient's physical condition. In addition, the ointment has a high concentration, good taste, and is easy to take and carry, making it very suitable for patients with weakness, premature aging, and chronic diseases who need long-term conditioning. It achieves an organic combination of treatment and conditioning and has broad prospects for clinical promotion and application. Detailed Implementation

[0027] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0028] Example 1: Preparation of Taiyi Yuansui Ointment using Standard Process

[0029] 1. Formula (by weight):

[0030] 30 parts yam, 30 parts Poria cocos, 6 parts ginseng (powdered)

[0031] 30 portions of each of the five processed Rehmannia glutinosa (totaling 150 portions): Rehmannia glutinosa processed with Amomum villosum, Rehmannia glutinosa processed with ginger, Rehmannia glutinosa processed with salt, Rehmannia glutinosa processed with milk, and Rehmannia glutinosa processed with wine.

[0032] 10 parts mulberry fruit, 10 parts wolfberry fruit, 30 parts plantain seed, 6 parts schisandra fruit, 30 parts dodder seed, 30 parts privet fruit, 9 parts burdock fruit.

[0033] 9 parts deer antler glue, 9 parts tortoise shell, 6 parts donkey-hide gelatin

[0034] Astragalus membranaceus 30 parts, Cistanche deserticola 30 parts, Cornus officinalis 30 parts, Paeonia suffruticosa 6 parts, Cibotium barometz 9 parts, Achyranthes bidentata 30 parts, Eucommia ulmoides (fried) 9 parts, Angelica sinensis 9 parts, processed turtle shell 15 parts, Asparagus cochinchinensis 15 parts

[0035] Prepare 30 portions of burdock seeds (for the melting step).

[0036] Honey as needed (as a flavoring agent and auxiliary ingredient).

[0037] 2. Preparation method:

[0038] (1) Pretreatment: Grind the three medicinal materials, yam, poria and ginseng, into fine powder using a grinder, pass them through a 100-mesh sieve, mix them evenly, and seal them for later use.

[0039] (2) Preparation of Rehmannia glutinosa: Take all five types of prepared Rehmannia glutinosa, place them in a decoction pot, add 8 times the amount of drinking water, and soak for 40 minutes. After bringing to a boil over high heat, simmer over low heat for 1.5 hours, and filter the decoction through a 200-mesh sieve. Wrap the dregs in double-layered gauze, squeeze out the juice under pressure, and combine the squeezed juice with the filtrate.

[0040] (3) Decoction of the ingredients: Place mulberry fruit, wolfberry fruit, plantain seed, schisandra fruit, dodder seed, privet fruit and burdock fruit (9 parts) together in another decoction pot, add 6 times the amount of drinking water, and soak for 30 minutes. After bringing to a boil over high heat, simmer over low heat for 1 hour, and filter out the decoction.

[0041] (4) Melting of gelatin: Place deer antler glue, tortoise shell and donkey-hide gelatin in a ceramic bowl, add rice wine (the amount should just submerge the glue blocks) and the remaining 30 parts of burdock seeds, and steam until melted, or stir in a 60℃ water bath until completely melted to obtain a melted liquid.

[0042] (5) Comprehensive decoction and concentration: Place Astragalus membranaceus, Cistanche deserticola, Cornus officinalis, Paeonia suffruticosa, Cibotium barometz, Achyranthes bidentata, stir-fried Eucommia ulmoides, Angelica sinensis, processed turtle shell, and Asparagus cochinchinensis into a decoction pot, add all the decoction obtained in steps (2) and (3), and add water until it covers the surface of the herbs by about 3 cm. After bringing to a boil over high heat, turn to low heat and decoct until the decoction becomes viscous (when scooped up with a spoon and poured down, the decoction flows in sheets).

[0043] (6) Concentrating the paste: Slowly add the melted liquid obtained in step (4) to the concentrated medicinal liquid, stirring constantly to mix it evenly. Continue to simmer over low heat, stirring constantly to prevent sticking to the pot, until the paste reaches the "hanging flag" state (when you dip a bamboo stick into the paste, the paste hangs down in a sheet rather than dripping).

[0044] (7) Mixing powder and forming paste: Remove from heat and wait until the temperature of the paste drops to about 60°C. Add the fine powder of medicinal materials prepared in step (1) and an appropriate amount of honey. Stir vigorously until completely uniform and free of dry powder particles.

[0045] (8) Storage: Dispense the ointment into clean, dry glass jars, seal them, and store them in the refrigerator.

[0046] 3. Product Description:

[0047] The obtained Taiyi Yuansui Ointment is a dark brown, semi-fluid, viscous paste with a slightly fragrant odor and a sweet, slightly bitter taste. It has the effects of invigorating qi and nourishing yin, and harmonizing the heart and kidneys.

[0048] Example 2: Simplified process for preparing Taiyi Yuansui Ointment

[0049] This embodiment aims to illustrate that, while ensuring the core process, some steps can be simplified to adapt to different production conditions.

[0050] 1. Recipe:

[0051] Same as Example 1.

[0052] 2. Preparation method:

[0053] (1) Pretreatment: Same as in Example 1.

[0054] (2) Combined Decoction: To simplify the process, place all the following herbs (except those already powdered and those requiring melting) into a multi-functional extraction tank: Prepared Rehmannia glutinosa, Mulberry fruit, Lycium barbarum, Plantago asiatica, Schisandra chinensis, Cuscuta chinensis, Ligustrum lucidum, Arctium lappa (9 parts), Astragalus membranaceus, Cistanche deserticola, Cornus officinalis, Paeonia suffruticosa, Cibotium barometz, Achyranthes bidentata, Eucommia ulmoides (fried), Angelica sinensis, Prepared turtle shell, and Asparagus cochinchinensis. Add 10 times the amount of drinking water and soak for 1 hour. Decoction twice, the first time for 2 hours and the second time for 1.5 hours. Combine the two decoctions, let them stand to settle, and then take the supernatant and filter.

[0055] (3) Melting of adhesives: Same as in Example 1.

[0056] (4) Concentration and paste formation: Transfer the combined filtrate obtained in step (2) to a vacuum concentration tank and concentrate it at 60°C and -0.08 MPa to a thick paste with a relative density of 1.25 (measured at 60°C). Add the melting solution and continue to concentrate until it reaches the "hanging flag" state.

[0057] (5) Mixing powder and forming paste: Same as in Example 1.

[0058] 3. Product Description:

[0059] The resulting ointment has similar properties and odor to that of Example 1. This method is more suitable for industrial-scale mass production and is more efficient.

[0060] Example 3: Application Example for Patients with Heart Failure of Qi and Yin Deficiency Type

[0061] This embodiment aims to specifically demonstrate the application and effects of the ointment of the present invention in the target indication.

[0062] 1. Ointment preparation:

[0063] Taiyi Yuansui Ointment prepared using the method described in Example 1 or Example 2.

[0064] 2. Clinical Applications:

[0065] Target patients: Patients diagnosed with chronic heart failure of Qi and Yin deficiency type, with clinical manifestations such as palpitations, shortness of breath, sweating with exertion, mild edema of the limbs, soreness and weakness of the lower back and knees, aversion to cold accompanied by hot flashes in the palms and soles at night, and memory loss.

[0066] Dosage: Take 15 grams of the ointment (about one tablespoon) each time, swallowed with warm water, twice a day, once in the morning and once in the evening. A course of treatment consists of three consecutive months of use.

[0067] Observation of efficacy: After one course of treatment, most patients reported significant relief from palpitations and shortness of breath, increased endurance for daily activities, reduced night sweats and hot flashes, and improved mental and sleep conditions. Physical examination showed that patients' 6-minute walk test distance was significantly increased compared to before treatment, and BNP (brain natriuretic peptide) levels decreased, indicating improved cardiac function.

[0068] Conclusion: The Taiyi Yuansui Ointment of the present invention has good clinical efficacy for chronic heart failure of Qi and Yin deficiency type, and can effectively improve patients' symptoms and quality of life.

[0069] Experiment 1: Verification of core efficacy (compared with classic prescriptions).

[0070] Experimental model: A rat model of chronic heart failure induced by coronary artery ligation was used to successfully simulate the pathogenesis of "qi deficiency and blood stasis, yang deficiency and water retention, and heart-kidney disharmony".

[0071] Observation period: 8 weeks after drug intervention.

[0072] Comparison of data parameter table:

[0073] Observation indicators Control group (healthy rats) Model group (no drug administered) Liuwei Dihuang Pills Shengmai Yin Group Jin Kui Shen Qi Wan group The Taiyi Yuansui Ointment of this invention Cardiac function indicators (ultrasound) Left ventricular ejection fraction (LVEF, %) 78.5 ± 3.2 42.3 ± 4.1 46.2 ± 3.8 58.9 ± 4.5 51.4 ± 3.9 67.8 ± 3.6 Left ventricular end-systolic diameter (LVESd, mm) 3.1 ± 0.3 5.8 ± 0.4 5.5 ± 0.3 4.6 ± 0.3 5.1 ± 0.4 3.9 ± 0.3 Cardiac biomarkers Plasma BNP (pg / ml) 125 ± 15 485 ± 35 435 ± 30 320 ± 25 380 ± 28 210 ± 20 Indicators related to "kidney deficiency" Swimming time with added weight (min) 25.5 ± 2.1 11.2 ± 1.5 15.8 ± 1.6 14.3 ± 1.4 17.1 ± 1.8 22.4 ± 1.9 Serum testosterone (ng / ml) 3.5 ± 0.4 1.6 ± 0.2 2.5 ± 0.3 1.8 ± 0.2 2.8 ± 0.3 3.1 ± 0.3 Indicators related to "Yin deficiency / water retention" 24-hour urine output (ml) 15.2 ± 1.2 8.1 ± 0.9 9.5 ± 1.0 11.3 ± 1.1 10.2 ± 1.0 13.8 ± 1.1 Foot edema index (%) 100.0 ± 2.5 135.6 ± 5.8 128.4 ± 4.1 118.5 ± 3.9 125.7 ± 4.5 108.3 ± 3.5

[0074] Synergistic cardiotonic effect: In terms of the core cardiac function indicator LVEF, the present invention group (67.8%) was significantly higher than all positive control groups, especially the "Shengmai Yin" (58.9%) which simply tonifies Qi and nourishes Yin and the "Jinkui Shenqi Wan" (51.4%) which simply warms Yang. This indicates that the present invention produces a synergistic cardiotonic effect through "heart and kidney regulation".

[0075] Comprehensive advantages: This solution is significantly superior to the control formula with a single function in improving "kidney deficiency" indicators (physical strength, testosterone) and "water retention" indicators (diuresis, edema reduction). For example, while Shengmai Yin improves some cardiac function, its improvement on kidney deficiency indicators is limited; Liuwei Dihuang Wan and Jinkui Shenqi Wan focus on nourishing yin and warming yang respectively, but their cardiotonic effects are not as good as this invention.

[0076] Conclusion: The technical advantage of this treatment plan lies in its integrated treatment strategy, which can simultaneously and efficiently improve multiple pathological aspects of the heart, kidneys, qi, yin, and yang, something that no single-effect classic prescription can achieve.

[0077] Experiment 2: Verification of the rationality of the formula (compared with the simplified formula).

[0078] Experimental model: Same as Experiment 1.

[0079] Observation period: 8 weeks after drug intervention.

[0080] Comparison of data parameter tables (focusing on core indicators):

[0081] Observation indicators Model group Complete formula (this invention) Missing Five-Seed Progeny Pill Set Groups lacking glue Special processing group for Rehmannia glutinosa LVEF (%) 42.3 ± 4.1 67.8 ± 3.6 55.2 ± 3.9 58.1 ± 4.0 60.5 ± 3.8 Plasma BNP (pg / ml) 485 ± 35 210 ± 20 295 ± 25 275 ± 22 255 ± 21 Swimming time with added weight (min) 11.2 ± 1.5 22.4 ± 1.9 17.5 ± 1.7 16.8 ± 1.6 19.1 ± 1.8 Incidence of gastrointestinal reactions - 0% 10% 5% 25%

[0082] Formula integrity is crucial: the absence of any key component can lead to a significant decrease in efficacy.

[0083] The group lacking the Five Seeds showed a clear disadvantage in improving physical strength (swimming time), proving that the Five Seeds are irreplaceable in tonifying the kidneys, replenishing essence, and enhancing fundamental vitality.

[0084] In the group with collagen deficiency, the effects on improving cardiac function (LVEF) and energy (BNP, physical strength) were reduced, proving that replenishing essence and blood with "products with affection within the blood" is the core element of the therapeutic effect.

[0085] The ordinary Rehmannia glutinosa group: Although the decline in core indicators was not as drastic as the previous two groups, the incidence of gastrointestinal reactions was as high as 25%, while the complete formula of this regimen was 0%. This illustrates the technical effect of the "five-process Rehmannia glutinosa" processing technique: while retaining the yin-nourishing effects of Rehmannia glutinosa, it reduces its cloying nature through various excipients, significantly reducing the side effects of taking the medicine and improving patient compliance and medication safety.

[0086] Experiment 3: Verification of the superiority of the preparation process.

[0087] Observation method: The content of effective ingredients in finished ointments prepared by different processes was determined.

[0088] Comparison of data parameters (determination of active ingredient content):

[0089] Analyzing components (representative medicinal materials) Standard process group (this invention) Mixed frying group Direct-cooking group of gelatinous products Ginsenoside Rg1 (Ginseng, invigorating qi) 1.52 mg / g 1.05 mg / g (↓31%) 1.38 mg / g (↓9%) Verbascoside (Rehmannia glutinosa, yin-nourishing) 2.85 mg / g 1.78 mg / g (↓38%) 2.61 mg / g (↓8%) Total amino acid content (deer antler glue, aphrodisiac and sperm-replenishing agent) 45.6 mg / g 38.2 mg / g (↓16%) 28.5 mg / g (↓38%) Paste stability (water separation rate after centrifugation) < 3% 8% 12%

[0090] Advantages of step-by-step decoction: The content of all indicators in the "mixed decoction group" decreased significantly, proving that the step-by-step decoction method adopted in this invention (decoct Rehmannia glutinosa first, then Codonopsis pilosula, and then add other herbs) can extract the effective components of different herbs to the greatest extent and avoid component damage or insufficient dissolution caused by improper decoction time.

[0091] The key role of the melting process: The total amino acid content of the "direct decoction group" drops by 38% because direct decoction of gelatinous materials easily sticks to the pot, gelatinizes, and adsorbs with other medicinal residues, resulting in significant losses. The "melting and mixing" process of this invention can almost completely preserve the active ingredients of these expensive and rare medicinal materials, ensuring efficacy. This is the direct technical effect brought about by the process.

[0092] Product physical stability: The ointment of this invention has the best stability, low water separation rate, and is easy to store and take, reflecting the overall maturity of the preparation process.

[0093] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A medicinal paste formula based on the dual replenishment of Qi and blood and the regulation of the heart and kidneys, characterized in that: Made from the following ingredients in parts by weight: 25-35 parts of Dioscorea opposita, 25-35 parts of Poria cocos, 5-7 parts of Ginseng, 120-180 parts of Rehmannia glutinosa, 8-12 parts of Morus alba, 8-12 parts of Lycium barbarum, 25-35 parts of Plantago asiatica, 5-7 parts of Schisandra chinensis, 25-35 parts of Cuscuta chinensis, 25-35 parts of Ligustrum lucidum, 35-45 parts of Arctium lappa, 8-10 parts of Cervi cornu colla, 8-10 parts of tortoise shell, 5-7 parts of donkey-hide gelatin, 25-35 parts of Astragalus membranaceus, 25-35 parts of Cistanche deserticola, 25-35 parts of Cornus officinalis, 5-7 parts of Paeonia suffruticosa, 8-10 parts of Cibotium barometz, 25-35 parts of Achyranthes bidentata, 8-10 parts of Eucommia ulmoides (fried), 8-10 parts of Angelica sinensis, 13-17 parts of processed turtle shell, and 13-17 parts of Asparagus cochinchinensis.

2. The herbal paste formula based on replenishing both Qi and Blood and regulating the Heart and Kidneys according to claim 1, characterized in that: The prepared Rehmannia glutinosa is processed Rehmannia glutinosa, and the processing method includes at least one of the following: processed with Amomum villosum, processed with ginger, processed with salt, processed with milk, and processed with wine.

3. The herbal paste formula based on dual replenishment of Qi and blood and regulation of the heart and kidneys according to claim 1, characterized in that: The weight proportions of each ingredient are as follows: 30 parts yam, 30 parts poria cocos, 6 parts ginseng, 150 parts prepared rehmannia root, 10 parts mulberry fruit, 10 parts wolfberry fruit, 30 parts plantain seed, 6 parts schisandra fruit, 30 parts dodder seed, 30 parts privet fruit, 39 parts burdock seed, 9 parts deer antler glue, 9 parts tortoise shell, 6 parts donkey-hide gelatin, 30 parts astragalus root, 30 parts cistanche deserticola, 30 parts cornus officinalis, 6 parts peony bark, 9 parts cibotium barometz, 30 parts achyranthes bidentata, 9 parts stir-fried eucommia bark, 9 parts angelica sinensis, 15 parts prepared turtle shell, and 15 parts asparagus root.

4. A method for preparing a traditional Chinese medicine paste formula based on the principles of nourishing both Qi and Blood and regulating the heart and kidneys, characterized in that... Includes the following steps: S1: Grind the yam, poria cocos, and ginseng into a fine powder and set aside; S2: Boil Rehmannia glutinosa in water for 1.5 hours, filter out the decoction, squeeze the juice from the dregs, and combine the decoctions; S3: Boil mulberry fruit, wolfberry fruit, plantain seed, schisandra fruit, dodder seed, privet fruit, and burdock fruit in water for 1 hour, then filter out the decoction; S4: Melt the deer antler glue, tortoise shell and donkey-hide gelatin to obtain a melted liquid; S5: Add water to decoct Astragalus membranaceus, Cistanche deserticola, Cornus officinalis, Paeonia suffruticosa, Cibotium barometz, Achyranthes bidentata, stir-fried Eucommia ulmoides, Angelica sinensis, prepared turtle shell, and Asparagus cochinchinensis. Add the decoction obtained in steps S2 and S3, as well as the melted liquid obtained in step S4, and concentrate to form a paste. S6: Add the fine powder obtained in step S1 and mix well to obtain the ointment.

5. The preparation method of the herbal paste formula D based on dual replenishment of qi and blood and regulation of heart and kidney as described in claim 4, characterized in that: The Rehmannia glutinosa mentioned in step S2 is a five-processed Rehmannia glutinosa, including Rehmannia glutinosa processed with Amomum villosum, Rehmannia glutinosa processed with ginger, Rehmannia glutinosa processed with salt, Rehmannia glutinosa processed with milk, and Rehmannia glutinosa processed with wine.

6. The use of herbal paste formulas based on replenishing both Qi and blood and regulating the heart and kidneys in the preparation of medicines for treating weakness or premature aging caused by deficiency of Qi and blood, Yang deficiency with water retention, and disharmony between the heart and kidneys.

7. The use of the herbal paste formula based on replenishing both Qi and Blood and regulating the Heart and Kidneys according to claim 6 in the preparation of a medicine for treating weakness or premature aging caused by deficiency of Qi and Blood, Yang deficiency with water retention, and disharmony between the Heart and Kidneys, characterized in that: The symptoms of general weakness or premature aging include palpitations and shortness of breath, edema of the limbs, sweating easily, soreness and weakness of the lower back and knees, memory decline, premature graying and loss of hair, loose teeth and weak bones, aversion to cold or hot flashes at night.

8. The use of a traditional Chinese medicine formula based on replenishing both Qi and Blood and regulating the heart and kidneys in the preparation of a drug for treating chronic heart failure or arrhythmia caused by deficiency of both Qi and Yin.