Compound selenium disulfide anti-dandruff agent as well as preparation method and application thereof

Abstract

The invention relates to the technical field of raw materials of shampoo products, and particularly discloses a compound selenium disulfide anti-dandruff agent as well as a preparation method and application thereof. The compound selenium disulfide anti-dandruff agent comprises the following components in parts by mass: 15-18 parts of selenium disulfide; 58-66 parts of a composite plant extract; 10 to 22 parts of a solvent; the composite plant extract is prepared by compounding an artemisia annua extract, a polygonum cuspidatum extract and a peony root bark extract. The anti-dandruff agent has the advantage that the anti-dandruff agent still has a very remarkable anti-dandruff effect under the condition of low-concentration usage amount of selenium disulfide.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of shampoo raw materials, in particular to a compound selenium disulfide antidandruff agent and its preparation method and application. BACKGROUND

[0002] Selenium disulfide is an antifungal agent that can inhibit fungal growth and reduce the excessive keratinization of scalp cells. Therefore, it is often used to treat seborrheic dermatitis, folliculitis, pityriasis versicolor (tinea versicolor) and dandruff and other problems. Selenium disulfide is used in shampoo to directly kill Malassezia, Trichophyton and other pathogenic fungi related to dandruff, folliculitis and seborrheic dermatitis by interfering with the synthesis of fungal cell walls.

[0003] Shampoo with added selenium disulfide has the effects of dandruff removal and oil control. However, in order to have good dandruff removal and oil control effects, the concentration of selenium disulfide in the commonly seen selenium disulfide shampoo on the market is usually 0.3-0.6%. Such a concentration of shampoo can easily inhibit the growth of scalp epidermal cells and excessively remove the natural oil of the scalp after being used for more than 3-4 weeks due to excessive selenium disulfide, which can cause dry scalp, itching, and can easily cause dry and rough hair, easy breakage, and even can cause allergic reactions. However, if the amount of selenium disulfide is reduced in order to alleviate the above problems, the bacteriostatic effect will be significantly reduced, resulting in a significant decrease in dandruff removal effect, which is difficult to meet the use requirements, and therefore there is still room for improvement. SUMMARY

[0004] In order to still have very significant dandruff removal effect at a low concentration of selenium disulfide, the present application provides a compound selenium disulfide antidandruff agent, its preparation method and application.

[0005] In a first aspect, the present application provides a compound selenium disulfide antidandruff agent, which adopts the following technical solution: A compound selenium disulfide antidandruff agent comprises the following components in mass fraction: 15-18 parts of selenium disulfide; 58-66 parts of a composite plant extract; 10-22 parts of a solvent; The composite plant extract is a composite of artemisia annua extract, giant knotweed extract and peony root extract.

[0006] By adopting the technical scheme, the composite plant extract is compounded by adding artemisia annua extract, polygonum cuspidatum extract and peony root bark extract, and the amount of the composite plant extract is higher than that of selenium disulfide, so that after the compound selenium disulfide dandruff remover is added to the shampoo, the content of selenium disulfide is low, but the dandruff removal effect is still very significant, and the soothing effect is also significant, which can significantly relieve the discomfort of the scalp, reduce the itching and redness of the scalp, and also has a good free radical scavenging effect, reduces the aging of the scalp, thereby activates the hair follicle activity, and makes the hair healthier.

[0007] Preferably, the mass ratio of the artemisia annua extract, the polygonum cuspidatum extract and the peony root bark extract is 54-60:2-3:2-3.

[0008] By adopting the technical scheme, the mass ratio of the artemisia annua extract, the polygonum cuspidatum extract and the peony root bark extract is specifically selected, so that the active ingredients are combined in a specific ratio to achieve better synergistic effect, and the effects of dandruff removal, soothing and anti-aging are more significant.

[0009] Preferably, the solvent is butanediol.

[0010] By adopting the technical scheme, the solvent is specifically selected as butanediol, so that the solubility of the composite plant extract in the solvent is higher, and the active ingredients can better synergize to achieve better effects.

[0011] Preferably, the preparation method of the artemisia annua extract is as follows: Step 1), artemisia annua is put into No. 6 solvent oil, and extraction is carried out at 60-64°C, and the filtrate is taken to obtain artemisia annua crude extract liquid; Step 2), the artemisia annua extract liquid is concentrated to a paste, then the paste is dissolved in an ethanol solution, then decolorization treatment is carried out, and finally ethanol and water are removed to obtain artemisia annua extract.

[0012] By adopting the technical scheme, a special extraction process is adopted, and the artemisia annua extract prepared by the process contains special active ingredients, which can better cooperate with the active ingredients of other extracts, and the effects of dandruff removal, soothing and anti-aging are more significant.

[0013] Preferably, the preparation method of the polygonum cuspidatum extract is as follows: Step 01), the polygonum cuspidatum rhizome is put into water, acid cellulase is added, the pH is adjusted to 5-6, and enzyme hydrolysis is carried out to obtain pretreated polygonum cuspidatum rhizome raw material; Step 02), ethanol aqueous solution is added to the pretreated polygonum cuspidatum rhizome raw material, extraction is carried out at 54-56°C, filtration is carried out, and the filtrate is taken to obtain polygonum cuspidatum extract liquid; Step 03), the polygonum cuspidatum extract liquid is concentrated to a paste to obtain polygonum cuspidatum extract.

[0014] By adopting the above technical scheme, through the special extraction process, the active ingredients in the extracted Polygonum cuspidatum are special, which can better play a synergistic effect with other active ingredients, and the effects of dandruff removal, soothing and anti-aging are better.

[0015] Preferably, the preparation method of the peony root bark extract is as follows: Step 001), the peony root bark is soaked in water to obtain wet peony root bark raw material; Step 002), the wet peony root bark raw material is heated and distilled by water vapor, and the condensate is collected; Step 003), the condensate is subjected to oil-water separation, and the upper layer is taken out. After drying the upper layer, the peony root bark extract is obtained.

[0016] By adopting the above technical scheme, through the special extraction process, the active ingredients in the extracted peony root bark are special, which can better improve the effects of dandruff removal, soothing and anti-aging in cooperation with other active ingredients.

[0017] In the second aspect, the application provides a preparation method of a compound selenium disulfide dandruff remover, which adopts the following technical scheme: a preparation method of the compound selenium disulfide dandruff remover described above, comprising the following steps: Step 0001), mix butanediol, Polygonum cuspidatum extract and peony root bark extract at 40-60°C until dissolved to obtain a premix; Step 0002), add Artemisia annua extract to the premix and mix uniformly to obtain a mixture; Step 0003), add selenium disulfide to the mixture and mix uniformly to obtain the compound selenium disulfide dandruff remover.

[0018] By adopting the above technical scheme, the compound selenium disulfide dandruff remover is added to the shampoo product, so that the concentration of selenium disulfide is low, which is not easy to cause adverse phenomena of the scalp and hair, and the compound selenium disulfide dandruff remover has very significant effects of dandruff removal, soothing and anti-aging, which can well care for the scalp and make the scalp and hair healthier.

[0019] In the third aspect, the application provides an application of a compound selenium disulfide dandruff remover, which adopts the following technical scheme: The application of the compound selenium disulfide dandruff remover described above, wherein the compound selenium disulfide dandruff remover is added to the shampoo product formula to prepare a shampoo product with mild dandruff removal effect.

[0020] By adopting the above technical scheme, the prepared shampoo product has significant dandruff removal effect and can well relieve the discomfort of the scalp, so that the hair is healthier.

[0021] In summary, the application has the following beneficial effects: 1. Because this application uses a compound plant extract made by adding Artemisia annua extract, Polygonum cuspidatum extract, and Paeonia suffruticosa root bark extract, and the amount of the compound plant extract is higher than that of selenium disulfide, the content of selenium disulfide is lower when the compound selenium disulfide antidandruff agent is added to the shampoo, but it can still play a very significant antidandruff role and has a significant soothing effect. It can significantly relieve scalp discomfort, reduce scalp itching, redness and swelling, and has a good effect of scavenging free radicals, reducing scalp aging, thereby activating hair follicle activity and making hair healthier.

[0022] 2. In this application, the preferred method is to select the specific mass ratio of Artemisia annua extract, Polygonum cuspidatum extract, and Paeonia suffruticosa root bark extract so that the active ingredients can be combined in a specific ratio to achieve better synergistic effects and more significant effects in removing dandruff, soothing, and anti-aging.

[0023] 3. In this application, a special extraction process is preferably used to enhance the synergistic effect of the active ingredients in Artemisia annua extract, Polygonum cuspidatum extract, and Paeonia suffruticosa root bark extract, resulting in better scalp and hair care. Detailed Implementation

[0024] The present application will be further described in detail below with reference to the embodiments.

[0025] Example 1 A compound selenium disulfide antidandruff agent is prepared as follows: Step 0001): Add 10 kg of butylene glycol, 2 kg of Polygonum cuspidatum extract and 2 kg of Paeonia suffruticosa root bark extract to a stirring vessel, heat to 40°C, rotate at 60 r / min, stir for 10 min, mix until dissolved, and obtain a premix.

[0026] Step 0002): Add 54 kg of Artemisia annua extract to the premix, stir at 60 r / min for 10 min, mix evenly to obtain the mixture.

[0027] Step 0003): Add 15 kg of selenium disulfide to the mixture, stir at 60 r / min for 10 min, mix evenly, and obtain compound selenium disulfide anti-dandruff agent.

[0028] Butylene glycol was purchased from Xinrong Biotechnology (Guangzhou) Co., Ltd., 1,3-Butylene glycol.

[0029] Selenium disulfide was purchased from Toronto Footing Stone Chemicals Company Ltd.

[0030] Artemisia annua extract was prepared in-house, and the preparation method is as follows: Step 1), dry artemisia annua plants are crushed into coarse powder and passed through a 40-mesh sieve to obtain artemisia annua powder. 100 kg of the artemisia annua powder is put into a reaction kettle, followed by 800 kg of No. 6 solvent oil. The mixture is heated to 60°C and extracted for 3 hours. Filtration is performed to obtain a first filtrate and a first residue. The first residue is put into a reaction kettle, followed by 600 kg of No. 6 solvent oil. The mixture is heated to 60°C and extracted for 2 hours. Filtration is performed to obtain a second filtrate. The first filtrate and the second filtrate are combined to obtain a crude artemisia annua extract.

[0031] Step 2), the artemisia annua extract is concentrated by rotary evaporation at 0.1 MPa and 60°C until a paste is obtained. The paste is dissolved in an ethanol aqueous solution with a mass concentration of 95%. The mass of the ethanol aqueous solution is 3 times the mass of the paste. The mixture is heated to 60°C and stirred until the paste is dissolved. Activated carbon is added for decolorization treatment. Filtration is performed to obtain a filtrate. The filtrate is concentrated by rotary evaporation at 0.1 MPa and 60°C to remove ethanol and water. A brownish yellow liquid is obtained, which is the artemisia annua extract.

[0032] The artemisia annua plants are commercially available and are dry products.

[0033] The No. 6 solvent oil is purchased from Guangzhou Huihe Chemical Co., Ltd.

[0034] The ethanol aqueous solution is commercially available.

[0035] The activated carbon is commercially available.

[0036] The polygonum cuspidatum extract is self-prepared according to the following method: Step 01), dry polygonum cuspidatum rhizomes are crushed and passed through a 40-mesh sieve to obtain polygonum cuspidatum rhizome powder. 100 kg of the polygonum cuspidatum rhizome powder is put into a reaction kettle, followed by 300 kg of water, 0.2 kg of acid cellulase, and citric acid to adjust the pH to 5. The mixture is subjected to enzymatic hydrolysis at a sealed state for 20 hours to obtain pretreated polygonum cuspidatum rhizome raw materials.

[0037] Step 02), 2000 kg of an ethanol aqueous solution with a mass concentration of 80% is added to the pretreated polygonum cuspidatum rhizome raw materials. The mixture is extracted at 54°C for 4 hours. Filtration is performed to obtain a filtrate, which is the polygonum cuspidatum extract.

[0038] Step 03), the polygonum cuspidatum extract is subjected to high-speed centrifugation and filtration twice through ceramic membranes with particle sizes of 200 nanometers and 10 nanometers, respectively, to obtain a refined polygonum cuspidatum extract. The refined polygonum cuspidatum extract is concentrated by rotary evaporation at 0.1 MPa and 55°C until a paste is obtained, which is the polygonum cuspidatum extract.

[0039] The polygonum cuspidatum rhizomes are commercially available and are dry products.

[0040] The acid cellulase is purchased from Guangzhou Tianjia Biological Technology Co., Ltd.

[0041] Citric acid was commercially available.

[0042] Ethanol aqueous solution was commercially available.

[0043] Peony root bark extract was self-made, and the preparation method was as follows: Step 001), dry peony root bark was crushed and passed through a 40-mesh sieve to obtain peony root bark powder. 100 kg of the peony root bark powder was put into a reaction kettle, 200 kg of water was added, and the mixture was soaked for 2 h to obtain wet peony root bark raw material.

[0044] Step 002), the wet peony root bark raw material was put into a distillation kettle and heated and distilled by steam to collect the condensate.

[0045] Step 003), the condensate was flowed into an oil-water separator for oil-water separation. After the mixture was separated into layers, the water was at the bottom, and the upper layer was taken. The upper layer was dried by rotary evaporation at 0.1 MPa and 45℃ to obtain peony root bark extract in powder form.

[0046] Peony root bark was commercially available, and was in dry form.

[0047] Example 2 A compound selenium disulfide antidandruff agent was prepared according to the following method: Step 0001), 20 kg of butanediol, 2.5 kg of giant knotweed extract, and 2.5 kg of peony root bark extract were put into a stirring kettle, heated to 50℃, stirred at a speed of 60 r / min for 10 min, mixed until dissolved, and a premix was obtained.

[0048] Step 0002), 57 kg of artemisia annua extract was added to the premix, stirred at a speed of 60 r / min for 10 min, and mixed uniformly to obtain a mixture.

[0049] Step 0003), 16.5 kg of selenium disulfide was added to the mixture, stirred at a speed of 60 r / min for 10 min, and mixed uniformly to obtain a compound selenium disulfide antidandruff agent.

[0050] Butanediol was purchased from Xirong Biotechnology (Guangzhou) Co., Ltd., 1,3-butylene glycol Selenium disulfide was purchased from Toronto Footing Stone Chemicals Company Ltd.

[0051] Artemisia annua extract was self-made, and the preparation method was as follows: Step 1), dry artemisia annua plants are crushed into coarse powder, which is passed through a 40-mesh sieve to obtain artemisia annua powder. 100 kg of the artemisia annua powder is put into a reaction kettle, followed by 800 kg of No. 6 solvent oil. The mixture is heated to 62°C and extracted for 3 hours. Filtration is performed to obtain a first filtrate and a first residue. The first residue is put into a reaction kettle, followed by 600 kg of No. 6 solvent oil. The mixture is heated to 62°C and extracted for 2 hours. Filtration is performed to obtain a second filtrate. The first filtrate and the second filtrate are combined to obtain a crude artemisia annua extract.

[0052] Step 2), the artemisia annua extract is concentrated by rotary evaporation at 0.1 MPa and 60°C until a paste is obtained. The paste is dissolved in an ethanol aqueous solution with a mass concentration of 95%. The mass of the ethanol aqueous solution is 3 times the mass of the paste. The mixture is heated to 60°C and stirred until the paste is dissolved. Activated carbon is then added for decolorization treatment. Filtration is performed to obtain a filtrate. The filtrate is concentrated by rotary evaporation at 0.1 MPa and 60°C to remove ethanol and water. A brownish yellow liquid is obtained, which is the artemisia annua extract.

[0053] The artemisia annua plants are commercially available and are in dry form.

[0054] The No. 6 solvent oil is purchased from Guangzhou Huihe Chemical Co., Ltd.

[0055] The ethanol aqueous solution is commercially available.

[0056] The activated carbon is commercially available.

[0057] The polygonum cuspidatum extract is self-prepared according to the following method: Step 01), dry polygonum cuspidatum rhizomes are crushed and passed through a 40-mesh sieve to obtain polygonum cuspidatum rhizome powder. 100 kg of the polygonum cuspidatum rhizome powder is put into a reaction kettle, followed by 300 kg of water, 0.2 kg of acid cellulase, and citric acid to adjust the pH to 5.5. The mixture is enzymatically hydrolyzed at a sealed state for 20 hours to obtain pretreated polygonum cuspidatum rhizome raw material.

[0058] Step 02), 2000 kg of an ethanol aqueous solution with a mass concentration of 80% is added to the pretreated polygonum cuspidatum rhizome raw material. The mixture is extracted at 55°C for 4 hours. Filtration is performed to obtain a polygonum cuspidatum extract.

[0059] Step 03), the polygonum cuspidatum extract is subjected to high-speed centrifugation and filtration twice using a 200-nanometer ceramic membrane and a 10-nanometer ceramic membrane to obtain a refined polygonum cuspidatum extract. The refined polygonum cuspidatum extract is concentrated by rotary evaporation at 0.1 MPa and 55°C until a paste is obtained, which is the polygonum cuspidatum extract.

[0060] The polygonum cuspidatum rhizomes are commercially available and are in dry form.

[0061] The acid cellulase is purchased from Guangzhou Tianjia Biological Technology Co., Ltd.

[0062] Citric acid was commercially available.

[0063] Ethanol aqueous solution was commercially available.

[0064] Paeonia suffruticosa root bark extract was self-made, and the preparation method was as follows: Step 001), dry Paeonia suffruticosa root bark was crushed and passed through a 40-mesh sieve to obtain Paeonia suffruticosa root bark powder. 100 kg of the Paeonia suffruticosa root bark powder was put into a reaction kettle, 200 kg of water was added, and the mixture was soaked for 2 h to obtain wet Paeonia suffruticosa root bark raw material.

[0065] Step 002), the wet Paeonia suffruticosa root bark raw material was put into a distillation kettle and heated and distilled by steam to collect a condensate.

[0066] Step 003), the condensate was flowed into an oil-water separator for oil-water separation. After the mixture was layered, the water was at the bottom, and the upper layer was taken. The upper layer was dried by rotary evaporation at 0.1 MPa and 45 ℃ to obtain Paeonia suffruticosa root bark extract in powder form.

[0067] Paeonia suffruticosa root bark was commercially available, and was in dry form.

[0068] Example 3 A compound selenium disulfide antidandruff agent was prepared according to the following method: Step 0001), 22 kg of butanediol, 3 kg of Polygonum cuspidatum extract, and 3 kg of Paeonia suffruticosa root bark extract were put into a stirring kettle, heated to 60 ℃, and stirred at a speed of 60 r / min for 10 min until mixed and dissolved to obtain a premix.

[0069] Step 0002), 60 kg of Artemisia annua extract was added to the premix, and the mixture was stirred at a speed of 60 r / min for 10 min until uniformly mixed to obtain a mixture.

[0070] Step 0003), 18 kg of selenium disulfide was added to the mixture, and the mixture was stirred at a speed of 60 r / min for 10 min until uniformly mixed to obtain a compound selenium disulfide antidandruff agent.

[0071] Butanediol was purchased from Xirong Biotechnology (Guangzhou) Co., Ltd., and 1,3-butylene glycol Selenium disulfide was purchased from Toronto Footing Stone Chemicals Company Ltd.

[0072] Artemisia annua extract was self-made, and the preparation method was as follows: Step 1), dry artemisia annua plants are crushed into coarse powder and passed through a 40-mesh sieve to obtain artemisia annua powder. 100 kg of the artemisia annua powder is put into a reaction kettle, followed by 800 kg of No. 6 solvent oil. The mixture is heated to 64°C and extracted for 3 h. Filtration is performed to obtain a first filtrate and a first residue. The first residue is put into a reaction kettle, followed by 600 kg of No. 6 solvent oil. The mixture is heated to 64°C and extracted for 2 h. Filtration is performed to obtain a second filtrate. The first filtrate and the second filtrate are combined to obtain a crude artemisia annua extract.

[0073] Step 2), the artemisia annua extract is concentrated by rotary evaporation at 0.1 MPa and 60°C until a paste is obtained. The paste is dissolved in an ethanol aqueous solution with a mass concentration of 95%. The mass of the ethanol aqueous solution is 3 times the mass of the paste. The mixture is heated to 60°C and stirred until the paste is dissolved. Activated carbon is then added for decolorization treatment. Filtration is performed to obtain a filtrate. The filtrate is concentrated by rotary evaporation at 0.1 MPa and 60°C to remove ethanol and water. A brownish yellow liquid is obtained, which is the artemisia annua extract.

[0074] The artemisia annua plants are commercially available and are in dry form.

[0075] The No. 6 solvent oil is commercially available from Guangzhou Huihe Chemical Co., Ltd.

[0076] The ethanol aqueous solution is commercially available.

[0077] The activated carbon is commercially available.

[0078] The polygonum cuspidatum extract is self-prepared according to the following method: Step 01), dry polygonum cuspidatum rhizomes are crushed and passed through a 40-mesh sieve to obtain polygonum cuspidatum rhizome powder. 100 kg of the polygonum cuspidatum rhizome powder is put into a reaction kettle, followed by 300 kg of water, 0.2 kg of acid cellulase, and citric acid to adjust the pH to 6. The mixture is subjected to enzymatic hydrolysis at a sealed state for 20 h to obtain pretreated polygonum cuspidatum rhizome raw material.

[0079] Step 02), 2000 kg of an ethanol aqueous solution with a mass concentration of 80% is added to the pretreated polygonum cuspidatum rhizome raw material. The mixture is extracted at 56°C for 4 h. Filtration is performed to obtain a filtrate, which is the polygonum cuspidatum extract.

[0080] Step 03), the polygonum cuspidatum extract is subjected to high-speed centrifugation and filtration twice using a 200-nanometer ceramic membrane and a 10-nanometer ceramic membrane to obtain a refined polygonum cuspidatum extract. The refined polygonum cuspidatum extract is concentrated by rotary evaporation at 0.1 MPa and 55°C until a paste is obtained, which is the polygonum cuspidatum extract.

[0081] The polygonum cuspidatum rhizomes are commercially available and are in dry form.

[0082] The acid cellulase is commercially available from Guangzhou Tianjia Biological Technology Co., Ltd.

[0083] Citric acid is commercially available.

[0084] Ethanol aqueous solution is commercially available.

[0085] Paeonia suffruticosa root bark extract is self-made, and the preparation method is as follows: Step 001), dry Paeonia suffruticosa root bark is crushed and passed through a 40-mesh sieve to obtain Paeonia suffruticosa root bark powder. 100 kg of Paeonia suffruticosa root bark powder is put into a reaction kettle, 200 kg of water is added, and the mixture is soaked for 2 h to obtain wet Paeonia suffruticosa root bark raw material.

[0086] Step 002), the wet Paeonia suffruticosa root bark raw material is put into a distillation kettle and heated by steam distillation to collect the condensate.

[0087] Step 003), the condensate is flowed into an oil-water separator for oil-water separation. After layering, the water is at the bottom, and the upper layer is taken out. The upper layer is dried by rotary evaporation at 0.1 MPa and 45°C to obtain powdered Paeonia suffruticosa root bark extract.

[0088] Paeonia suffruticosa root bark is commercially available, and is a dry product.

[0089] Comparative Example 1 A compound selenium disulfide antidandruff agent, which is different from Example 2 only in that: Tea tree essential oil is used to replace artemisia annua extract in an equal amount.

[0090] Tea tree essential oil is purchased from Hubei Langbomwan Biomedicine Co., Ltd.

[0091] Comparative Example 2 A compound selenium disulfide antidandruff agent, which is different from Example 2 only in that: Patchouli essential oil is used to replace giant knotweed extract in an equal amount.

[0092] Patchouli essential oil is purchased from Shandong Luoheng Chemical Product Co., Ltd.

[0093] Comparative Example 3 A compound selenium disulfide antidandruff agent, which is different from Example 2 only in that: Peppermint essential oil is used to replace Paeonia suffruticosa root bark extract in an equal amount.

[0094] Peppermint essential oil is purchased from Guangzhou Puyifeng Biotechnology Co., Ltd.

[0095] Comparative Example 4 A compound selenium disulfide antidandruff agent, which is different from Example 2 only in that: Tea tree essential oil is used to replace artemisia annua extract, patchouli essential oil is used to replace giant knotweed extract, and peppermint essential oil is used to replace Paeonia suffruticosa root bark extract in an equal amount.

[0096] Tea tree essential oil is purchased from Hubei Langbomwan Biomedicine Co., Ltd.

[0097] The broadleaf sage essential oil was purchased from Shandong Luoheng Chemical Product Co., Ltd.

[0098] The peppermint essential oil was purchased from Guangzhou Puyifeng Biological Technology Co., Ltd.

[0099] Experiment 1 According to QB / T 2738-2012 “Evaluation method for antibacterial and bacteriostatic effect of daily chemical products” 7.5 bacteriostatic ring method, the test sample prepared by each example and the control sample was detected, the bacteriostatic ring diameter was used to evaluate the bacteriostatic effect, the larger the bacteriostatic ring diameter, the better the bacteriostatic effect, and the bacteriostatic ring diameter greater than 7 mm was determined to have bacteriostatic effect.

[0100] Test sample: 0.5 g of the antidandruff agent was taken, 99.5 g of deionized water was taken, and the mixture was uniformly mixed to obtain the test sample.

[0101] Control sample: 0.1 g of selenium disulfide was taken, 99.9 g of deionized water was taken, and the mixture was uniformly mixed to obtain the test sample.

[0102] Experiment 2 According to T / JSRH 003-2023 “Cosmetic raw material anti-allergy activity test hyaluronidase inhibition method”, the hyaluronidase inhibition rate (%) of the test sample prepared by each example and the control sample was detected.

[0103] Test sample: 0.5 g of the antidandruff agent was taken, 99.5 g of deionized water was taken, and the mixture was uniformly mixed to obtain the test sample.

[0104] Experiment 3 According to T / SHRH 006-2018 “Cosmetics- free radical (DPPH) scavenging experiment method”, the DPPH free radical scavenging rate (%) of the test sample prepared by each example and the control sample was detected.

[0105] Test sample: 0.5 g of the antidandruff agent was taken, 99.5 g of deionized water was taken, and the mixture was uniformly mixed to obtain the test sample.

[0106] The specific experimental data of experiments 1-3 are shown in Table 1.

[0107] Table 1 According to the data comparison of each example and the control sample in Table 1, the bacteriostatic ring diameter of each example is higher than that of each control sample, it can be seen that the compounding of artemisia annua extract, polygonum cuspidatum extract and peony root extract in each example can better cooperate with low concentration of selenium disulfide, and the bacteriostatic effect on malassezia is more significant, so that the use of low concentration of selenium disulfide still has very significant antidandruff effect.

[0108] The hyaluronidase inhibition rate (%) and DPPH free radical scavenging rate (%) of each embodiment are significantly higher than those of each comparative example, and it can be seen that each embodiment has very significant soothing and anti-aging effects by the cooperation of artemisia extract, giant knotweed extract and peony root bark extract, can significantly relieve scalp discomfort, and can well repair the scalp, make the scalp restore to youth and health, effectively promote hair follicle activity, and improve hair quality.

[0109] The specific embodiments are merely an explanation of the present application, and are not a limitation of the present application. Those skilled in the art can make modifications to the embodiments according to needs after reading the present specification, but as long as the modifications are within the scope of the claims of the present application, they are protected by the Patent Law.

Claims

1. A compound selenium disulfide anti-dandruff agent, characterized in that: The components include the following parts by mass: 15-18 parts of selenium disulfide; 58-66 parts of compound plant extract; Solvent 10-22 parts; The compound plant extract is a combination of Artemisia annua extract, Polygonum cuspidatum extract, and Paeonia suffruticosa root bark extract.

2. The compound selenium disulfide anti-dandruff agent according to claim 1, characterized in that: The mass ratio of Artemisia annua extract, Polygonum cuspidatum extract, and Paeonia suffruticosa root bark extract is 54-60:2-3:2-3.

3. The compound selenium disulfide anti-dandruff agent according to claim 2, characterized in that: The solvent is butanediol.

4. The compound selenium disulfide anti-dandruff agent according to claim 3, characterized in that: The preparation method of the Artemisia annua extract is as follows: Step 1) Add Artemisia annua to solvent oil No. 6 and extract at 60-64℃. Take the filtrate to obtain crude extract of Artemisia annua. Step 2) Concentrate the Artemisia annua extract into a paste, then dissolve the paste in an ethanol solution, decolorize it, and finally remove the ethanol and water to obtain the Artemisia annua extract.

5. A compound selenium disulfide anti-dandruff agent according to claim 4, characterized in that: The preparation method of the Polygonum cuspidatum extract is as follows: Step 01): Put the Polygonum cuspidatum rhizome into water, add acidic cellulase, adjust the pH to 5-6, and carry out enzymatic hydrolysis to obtain pretreated Polygonum cuspidatum rhizome raw material. Step 02): Add an ethanol aqueous solution to the pretreated Polygonum cuspidatum rhizome raw material, extract at 54-56℃, filter, and take the filtrate to obtain Polygonum cuspidatum extract; Step 03) Concentrate the Polygonum cuspidatum extract into a paste to obtain Polygonum cuspidatum extract.

6. The compound selenium disulfide anti-dandruff agent according to claim 5, characterized in that: The preparation method of the peony root bark extract is as follows: Step 001), soak the peony root bark in water to obtain wet peony root bark raw material; Step 002), the wet peony root bark raw material is heated and distilled by steam, and the condensate is collected; Step 003): Separate the condensate into oil and water, take the upper layer, and dry the upper layer to obtain peony root bark extract.

7. A method for preparing a compound selenium disulfide antidandruff agent according to any one of claims 1-6, characterized in that: Includes the following steps: Step 0001): Butylene glycol, Polygonum cuspidatum extract, and Paeonia suffruticosa root bark extract are mixed at 40-60°C until dissolved to obtain a premix. Step 0002): Add Artemisia annua extract to the premix and mix well to obtain a mixture; Step 0003): Add selenium disulfide to the mixture and mix well to obtain compound selenium disulfide anti-dandruff agent.

8. The application of a compound selenium disulfide antidandruff agent according to any one of claims 1-6, characterized in that: The compound selenium disulfide antidandruff agent is added to the shampoo formula to prepare shampoos with mild antidandruff effects.

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