Automatic calibration method for radiopharmaceutical dose

Abstract

The invention discloses a radiopharmaceutical dose automatic calibration method, which comprises the following steps of: performing charge state analysis on an iodine-131 radiopharmaceutical solution to determine the polarity and the intensity of an electrostatic charge required to be applied by a needle; before injection, static charges are applied to the needle head through the micro-current generating device, so that medicine can be effectively separated from the needle head after injection is completed, and residues are reduced; a high-precision micro-injection pump is combined with a pressure sensor to control the injection speed and dose output, and the fluid flowing state is monitored in real time to avoid abnormal conditions; after injection, a laser scattering detection module and an image recognition algorithm are used for capturing and evaluating the volume of residual liquid drops at the tail end of a needle head in real time, the dose needing to be additionally supplemented is calculated according to the volume, and it is ensured that a patient receives the accurate target dose; no needle residue is confirmed again after dose supplementation, so that the accuracy of the final administration dose is ensured; the whole system is flexible and high in adaptability, and can be adjusted according to the characteristics of different types of radiopharmaceuticals.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of radiopharmaceuticals, and particularly relates to a method for automatically calibrating the dose of a radiopharmaceutical. BACKGROUND

[0002] In the treatment of radiopharmaceuticals, accurate control of the administered dose is crucial to ensure therapeutic efficacy and reduce side effects. However, traditional injection methods have several limitations and challenges that limit the improvement of dose accuracy.

[0003] Firstly, during the injection of radiopharmaceuticals, drug residues often occur at the tip of the needle, mainly due to the adhesion between droplets and the needle surface. The presence of residual droplets means that the actual dose administered to the patient is lower than the prescribed requirement, which may lead to poor treatment results or the need for additional supplementary injections, increasing the inconvenience and risk to the patient.

[0004] Secondly, traditional injection devices have difficulty in achieving precise control of injection speed and dose. Even if a micro-injection pump is used, problems such as blockage and air bubbles may still occur, which not only affect the accuracy of the injection but also may cause medical accidents. In addition, the lack of real-time monitoring and feedback mechanisms makes it difficult for operators to discover and address these issues in a timely manner, further reducing dose accuracy.

[0005] Therefore, it is necessary to provide a method for automatically calibrating the dose of a radiopharmaceutical to solve the above technical problems. SUMMARY

[0006] The present application overcomes the shortcomings of the prior art and provides a method for automatically calibrating the dose of a radiopharmaceutical.

[0007] To achieve the above-mentioned purposes, the technical solution adopted by the present application is as follows: a method for automatically calibrating the dose of a radiopharmaceutical, comprising the following steps:

[0008] Performing charge state analysis on the iodine-131 radiopharmaceutical solution;

[0009] Applying an electrostatic charge to the needle before injection through a built-in micro-current generating device to facilitate the separation of the drug from the needle after injection is completed;

[0010] Using a micro-injection pump in combination with a pressure sensor to control the injection speed and dose output;

[0011] Combining a laser scattering detection module to capture in real time whether there are residual droplets at the tip of the needle and determine their volume size through image recognition algorithms;

[0012] Based on the volume estimation result of the residual droplets, the system calculates the additional dose that should be supplemented to ensure that the target dose received by the patient meets the prescription requirements.

[0013] In a preferred embodiment of the present invention, the method for charge state analysis is as follows:

[0014] To detect the ion concentration, pH value, and conductivity in radiopharmaceutical solutions;

[0015] Determine its overall charge state based on the electrochemical properties of the solution;

[0016] Select the matching static charge polarity and intensity based on the charge state to optimize the electric field distribution on the needle surface.

[0017] In a preferred embodiment of the present invention, the method of applying electrostatic charge to the needle before injection using a microcurrent generator is as follows:

[0018] During the injection preparation stage, the microcurrent generator is activated and the DC microcurrent is transmitted to the metal needle through the conductive connector.

[0019] The control system selects to apply either a positive or negative charge based on the charge state analysis results of the radiopharmaceutical solution;

[0020] This causes a localized electrostatic field to form on the surface of the needle due to the accumulation of charge. The direction of this electrostatic field is opposite to the polarity of the charge carried by the charged particles in the solution.

[0021] In a preferred embodiment of the present invention, the method for controlling the injection speed and dosage output by a micro-injection pump in conjunction with a pressure sensor is as follows:

[0022] Micro-injection pumps use high-precision stepper motors to drive the syringe piston, precisely controlling the speed and volume of drug injection;

[0023] The system sets the motor operating parameters according to the predetermined dosage and speed, and adjusts them through real-time feedback to ensure accuracy;

[0024] Pressure sensors installed in the injection channel monitor fluid flow and help detect abnormalities such as blockages or air bubbles, allowing for timely adjustments to injection parameters.

[0025] In a preferred embodiment of the present invention, the method for the laser scattering detection module to detect in real time whether there are residual droplets at the tip of the needle is as follows:

[0026] After the injection is completed, the laser scattering detection module is activated when it is necessary to detect whether there are residual droplets at the tip of the needle.

[0027] The transmitter emits a narrow laser beam that passes through the space at the tip of the needle;

[0028] If residual droplets are present, the laser beam will be scattered as it passes through the droplets;

[0029] The receiver is responsible for capturing these changes in scattered light caused by the droplets.

[0030] In a preferred embodiment of the present invention, the laser scattering detection module includes a transmitter and a receiver, located on both sides of the needle tip.

[0031] In a preferred embodiment of the present invention, a method for determining the volume of residual droplets at the tip of a needle using an image recognition algorithm is provided.

[0032] The images of the needle tip captured by the high-speed camera are processed using image recognition algorithms;

[0033] Extract the contour information of the residual droplets and calculate their projected area by combining the pixel scale factor;

[0034] The droplet volume is estimated based on empirical formulas to determine whether a supplemental dose is needed to ensure that the patient receives the accurate amount of medication.

[0035] In a preferred embodiment of the present invention, the system calculates the additional dose that should be supplemented:

[0036] The volume of residual droplets at the tip of the needle was determined using laser scattering detection and image recognition technology;

[0037] Based on the volume of the residual droplets and the characteristics of the radiopharmaceutical, the required supplemental dose is calculated using a built-in algorithm.

[0038] Adjust the parameters of the microinfusion pump to ensure accurate delivery of the required dose;

[0039] After replenishment, the tip of the needle is checked again to confirm that there is no residue and to ensure dosage accuracy.

[0040] In a preferred embodiment of the present invention, the characteristics of the radiopharmaceutical include, but are not limited to, half-life, electrochemical properties, etc.

[0041] This invention provides an automatic radiopharmaceutical dosage calibration method, which, based on the aforementioned automatic radiopharmaceutical dosage calibration method, includes:

[0042] The drug preparation and analysis module is used to perform charge state analysis on iodine-131 radiopharmaceutical solutions and determine the polarity and intensity of the static charge.

[0043] The electrostatic charge application module applies an optimized electrostatic charge to the needle before injection via a microcurrent generator to promote complete drug detachment from the needle.

[0044] The precision injection control module uses a combination of a micro-injection pump and a pressure sensor to precisely control the injection speed and dosage output, while monitoring abnormal situations during the injection process.

[0045] The residue detection module includes laser scattering detection and image recognition algorithms, which are used to capture and evaluate the volume of residual droplets at the tip of the needle in real time;

[0046] The dose correction module calculates the additional dose that needs to be supplemented based on the estimated results of residual droplets, ensuring that the patient receives the accurate target dose;

[0047] The feedback and adjustment mechanism is used to reconfirm that there are no residual droplets at the tip of the needle after supplementing the dose, ensuring the accuracy of the final dosage.

[0048] This invention addresses the shortcomings of the prior art and has the following beneficial effects:

[0049] (1) This invention provides an automatic calibration method for radiopharmaceutical dosage. By combining laser scattering detection technology and image recognition algorithm to capture residual droplets at the tip of the needle in real time, and estimating the additional dose required based on their size, this method can significantly improve the accuracy of the radiopharmaceutical dosage received by the patient. This not only ensures the effectiveness of the treatment, but also reduces the risk of side effects that may be caused by inaccurate dosage.

[0050] (2) This invention provides an automatic calibration method for radiopharmaceutical dosage, a method of applying static charge to the needle before injection, and a technique of using a micro-injection pump and pressure sensor to precisely control the injection speed and dose output, making the entire injection process safer and more efficient. This method can effectively avoid injection failures caused by abnormal conditions such as syringe blockage or air bubbles, while improving the consistency and stability of drug delivery.

[0051] (3) The present invention provides an automatic calibration method for radiopharmaceutical dosage. The system is designed to include multiple functional units such as a drug preparation and analysis module, a static charge application module, a precise injection control module, a residual detection module, and a dosage correction module. It can be adjusted according to the different characteristics of radiopharmaceuticals. This flexible design allows for personalized processing of different types of radiopharmaceuticals, greatly enhancing the applicability and operational flexibility of the system and providing strong support for clinical applications. Attached Figure Description

[0052] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0053] Figure 1 This is a schematic flowchart of a preferred embodiment of the present invention. Detailed Implementation

[0054] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0055] Many specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention can also be practiced in other ways different from those described herein. Therefore, the scope of protection of the invention is not limited to the specific embodiments disclosed below.

[0056] Figure 1 The illustration shows a flowchart of a machine learning-based radio signal identification method according to an embodiment of this application.

[0057] An automatic calibration method for radiopharmaceutical dosage according to an embodiment of this application includes the following steps:

[0058] Step S1: Perform charge state analysis on the iodine-131 radiopharmaceutical solution;

[0059] Step S2: Apply static charge to the needle before injection using the built-in microcurrent generator to cause the drug to detach from the needle after injection.

[0060] Step S3: Use a micro-injection pump in conjunction with a pressure sensor to control the injection speed and dosage output;

[0061] Step S4: Combine the laser scattering detection module to capture in real time whether there are residual droplets at the tip of the needle, and determine their size through image recognition algorithm;

[0062] Step S5: Based on the volume estimation of the residual droplets, the system calculates the additional dose that should be supplemented to ensure that the patient receives the target dose required by the prescription.

[0063] The following will describe each step in detail.

[0064] In step S1, the iodine-131 radiopharmaceutical solution is subjected to charge state analysis, including the detection of ion concentration, pH value and conductivity, and the polarity and intensity of the static charge to be applied by the needle are determined based on these parameters in order to optimize the injection process and reduce drug residue.

[0065] The method for charge state analysis is as follows: first, the ion concentration, pH value, and conductivity in the radiopharmaceutical solution are measured;

[0066] Then, the overall charge state is determined based on the electrochemical properties of the solution;

[0067] For example, high conductivity may indicate a high concentration of freely moving ions in the solution, while pH can help determine the concentration of hydrogen or hydroxide ions. Combining ion concentration information, it's possible to further infer whether the solution as a whole tends to be positively or negatively charged. Based on this understanding of the solution's charge state, appropriate electrostatic polarity and intensity can be applied to the needle to optimize the electric field distribution on the needle surface, ensuring that the drug detaches more effectively from the needle during injection, thereby reducing post-injection residue.

[0068] Finally, based on the determined charge state, a matching electrostatic charge polarity and intensity are selected to optimize the electric field distribution on the needle surface, ensuring that the drug can be more effectively removed from the needle and reducing post-injection residue.

[0069] In step S2, a built-in microcurrent generator applies a static charge to the needle before injection, causing the drug to detach from the needle after injection. Specifically, this includes:

[0070] During the injection preparation stage, the microcurrent generator is activated and the DC microcurrent is transmitted to the metal needle through the conductive connector.

[0071] Conductive connectors can be conductive spring sheets, metal contacts, or conductive coatings, etc.

[0072] The control system selects to apply either a positive or negative charge based on the charge state analysis results of the radiopharmaceutical solution;

[0073] Based on the charge state analysis results of the radiopharmaceutical solution obtained in step S1, the control system determines whether to apply a positive or negative charge to the needle.

[0074] For example:

[0075] If the solution as a whole is negatively charged, then apply a positive charge to the needle.

[0076] If the solution as a whole is positively charged, then apply a negative charge to the needle.

[0077] Once the desired charge polarity is determined, the microcurrent generator outputs a DC microcurrent of the corresponding polarity to the needle tip, causing charge to gradually accumulate on the needle tip surface, thereby creating a local electrostatic field at and near the tip.

[0078] The direction of this electrostatic field is opposite to the polarity of the charge carried by the charged particles in the solution;

[0079] For example:

[0080] If the ions in the solution are predominantly negatively charged, then a positive charge is applied to the needle, and the resulting electrostatic field is directed toward the inside of the needle.

[0081] This reverse electric field helps reduce the adhesion between the drug droplet and the needle, promoting rapid detachment of the drug from the needle after injection.

[0082] In step S3, a micro-injection pump is used in conjunction with a pressure sensor to control the injection speed and dose output;

[0083] The method for controlling the injection speed and dosage output using a micro-injection pump and a pressure sensor is as follows:

[0084] Micro-injection pumps use high-precision stepper motors to drive the syringe piston, precisely controlling the speed and volume of drug injection;

[0085] The system sets the motor operating parameters according to the predetermined dosage and speed, and adjusts them through real-time feedback to ensure accuracy;

[0086] Pressure sensors installed in the injection channel monitor fluid flow and help detect abnormalities such as blockages or air bubbles, allowing for timely adjustments to injection parameters.

[0087] Specific implementation methods and algorithm examples:

[0088] The algorithm for controlling injection speed and dosage is as follows:

[0089] V target Target injection volume (unit: mL);

[0090] t total Total injection time (unit: seconds);

[0091] υ target Target injection rate (unit: mL / s);

[0092]

[0093] θ: Stepper motor angular position (unit: °)

[0094] K υol Volume per revolution coefficient (unit: mL / rev): This indicates the volume of liquid medicine propelled by the motor per revolution.

[0095] N: Current number of steps for the stepper motor

[0096] but:

[0097] The current estimated injection volume is:

[0098]

[0099] The actual injection rate is calculated from the volume difference between adjacent time points:

[0100]

[0101] The control system adjusts the stepper motor drive current using a PID algorithm to achieve the actual speed υ real Approaching the set value υ target ,Right now:

[0102]

[0103] in:

[0104] e(t) = υ target -υ real (t): Velocity error;

[0105] u(t): Controller output, used to adjust the motor drive voltage or pulse frequency;

[0106] K p K i K d : Proportional, integral, and differential coefficients, preset or self-tuned.

[0107] Pressure sensor feedback control logic

[0108] set up:

[0109] P sensor Pressure value inside the flow channel measured by the pressure sensor (unit: kPa)

[0110] P threshold_block Blockage detection threshold

[0111] P threshold_bubble Bubble recognition pressure fluctuation threshold

[0112] like:

[0113] P sensor >P threshold_block If the system determines that the tubing or needle is blocked, it will pause the injection and trigger an alarm.

[0114] The pressure value fluctuates sharply in a short period of time (e.g., ΔP>P). threshold_bubble If the duration is less than 0.5 seconds, it is determined that there are air bubbles, and the system will prompt for a bubble removal operation or automatically execute the air venting program.

[0115] Example explanation:

[0116] Assuming a treatment requires a total injection volume of 1.5 mL of iodine-131, with an injection time of 3 minutes (180 seconds), the injection rate is set as follows:

[0117]

[0118] The micro-injection pump uses a stepper motor with a resolution of 400 steps / revolution, and the volume pushed per revolution is 0.03 mL. Therefore, the volume corresponding to each step is:

[0119]

[0120] To complete a 1.5 mL injection, the total number of steps required is:

[0121]

[0122] The system sets the motor operating parameters accordingly and adjusts the motor operation in real time through the aforementioned PID control algorithm to ensure stable injection speed. At the same time, the pressure sensor collects pressure data once per second. If a sudden pressure change is detected that exceeds the threshold, the corresponding processing procedure is triggered.

[0123] In step S4, the laser scattering detection module is used to capture in real time whether there are residual droplets at the tip of the needle, and the size of the droplets is determined by an image recognition algorithm.

[0124] Laser scattering detection module activation: After the injection process is completed, the system automatically triggers the residual droplet detection process. At this time, the laser scattering detection module is activated to detect whether there is any drug residue at the tip of the needle in real time.

[0125] The transmitter emits a narrow laser beam that passes through the space at the tip of the needle.

[0126] If there are residual droplets at the tip of the needle, the laser beam will be scattered when it passes through the droplets;

[0127] The receiver captures the changing signals of the scattered light, converts the optical signals into electrical signals, and transmits them to the control system for preliminary judgment.

[0128] Image acquisition and image recognition processing: To further accurately assess the volume of the residual droplets, the system simultaneously activates a high-speed camera to acquire images of the needle tip.

[0129] High-speed cameras acquire high-definition images of the area at the tip of the needle;

[0130] The image recognition algorithm processes the acquired images as follows:

[0131] Image preprocessing includes operations such as grayscale conversion, filtering and noise reduction, and edge enhancement.

[0132] Droplet contour extraction: The droplet boundary is extracted using edge detection algorithms (such as the Canny operator or a deep learning-based segmentation model);

[0133] Projected area calculation: based on pixel scale factor S (unit: mm) 2 ( / pixel), converts the pixel area to the actual physical area:

[0134] A = N pixels ×S

[0135] Where A is the projected area of ​​the droplet, N pixels This represents the number of pixels occupied by the droplet region.

[0136] Droplet volume estimation: Based on an empirical model where the droplet approximates a spherical cap shape, its volume is estimated using the projected area.

[0137] Let the droplet height be h and the base radius be r, then the volume can be estimated using an empirical formula:

[0138]

[0139] Or it can be simplified to a linear empirical relationship that depends only on the projected area A (as determined experimentally):

[0140] V = k·A 3 / 2

[0141] Where k is the volume conversion factor, which is pre-calibrated based on the physical properties of the droplet, such as surface tension and viscosity.

[0142] Determining if a supplemental dose is needed: The system compares the estimated residual droplet volume with a set threshold.

[0143] If V>V threshold The residue level was determined to be excessive, and dosage compensation was required.

[0144] If V≤V threshold It was determined that there were no significant residues and no supplementation was required.

[0145] This judgment result will serve as the input for the next dose correction step.

[0146] In step S5, based on the volume estimation of the residual droplets, the system calculates the additional dose that should be supplemented to ensure that the target dose received by the patient meets the prescription requirements.

[0147] After estimating the volume of the residual droplet at the tip of the needle (as described in step S4), the system enters the dose calibration phase, which specifically includes the following steps:

[0148] Obtaining residual droplet volume data: The volume estimation result V of the residual droplet at the tip of the needle is obtained from the laser scattering detection module and image recognition algorithm. residual .

[0149] Dosage conversion based on the characteristics of radiopharmaceuticals: Based on the physical and chemical characteristics of radiopharmaceuticals (such as iodine-131), including but not limited to: drug density ρ, radioactivity concentration (radioactivity per unit volume), and half-life correction factor f(t).

[0150] The system uses a built-in algorithm to convert the volume of the residual droplets into the actual lost radioactive dose D. loss :

[0151] D loss =V residual ·C radio ·f(t)

[0152] in:

[0153] C radio Radioactivity per unit volume of drug (e.g., μCi / mL);

[0154] f(t): Time decay factor, used to correct for activity decline caused by half-life since drug preparation.

[0155] Calculate the required supplemental dose: The system calculates the target dose D based on the prescription. taiget and the current injected dose D inj Combined with loss dose D loss Calculate the required supplemental dose D comp :

[0156] D comp =D taiget -D inj +D loss

[0157] Adjust the microinfusion pump parameters and perform a supplemental injection:

[0158] The system will replenish dose D comp Convert to volumetric volume and set new injection parameters for the microinjection pump;

[0159] The micro-injection pump initiates the supplementary injection process, and a high-precision stepper motor controls the injection speed and total volume.

[0160] During the injection process, pressure sensors continuously monitor the fluid status to ensure a stable and abnormal injection process.

[0161] After replenishment, check the residue again:

[0162] After the injection is completed, the system restarts the laser scattering detection module and high-speed camera to confirm whether there are still residual droplets at the tip of the needle;

[0163] If significant residues still exist, repeat the dose compensation process described above.

[0164] If there is no residue or the residue level is below the threshold, the final dosage is confirmed to meet the prescription requirements, and the injection process ends.

[0165] Based on the preferred embodiments of the present invention described above, those skilled in the art can make various changes and modifications without departing from the inventive concept. The technical scope of this invention is not limited to the contents of the specification, but must be determined according to the scope of the claims.

Claims

1. An automatic calibration method for radiopharmaceutical dosage, characterized in that, Includes the following steps: Charge state analysis of iodine-131 radiopharmaceutical solution; The built-in microcurrent generator applies a static charge to the needle before injection, causing the drug to detach from the needle after injection. A micro-injection pump, in conjunction with a pressure sensor, is used to control the injection speed and dosage output. Combined with a laser scattering detection module, it can capture in real time whether there are residual droplets at the tip of the needle, and determine their size through an image recognition algorithm; Based on the volume estimation of the residual droplets, the system calculates the additional dose that should be supplemented to ensure that the patient receives the target dose required by the prescription.

2. The automatic calibration method for radiopharmaceutical dosage according to claim 1, characterized in that: The method for charge state analysis is as follows: To detect the ion concentration, pH value, and conductivity in radiopharmaceutical solutions; Determine its overall charge state based on the electrochemical properties of the solution; Select the matching static charge polarity and intensity based on the charge state to optimize the electric field distribution on the needle surface.

3. The automatic calibration method for radiopharmaceutical dosage according to claim 1, characterized in that: The method of applying static charge to the needle before injection using a microcurrent generator is as follows: During the injection preparation stage, the microcurrent generator is activated and the DC microcurrent is transmitted to the metal needle through the conductive connector. The control system selects to apply positive or negative charge based on the charge state analysis results of the radiopharmaceutical solution; This causes a localized electrostatic field to form on the surface of the needle due to the accumulation of charge. The direction of this electrostatic field is opposite to the polarity of the charge carried by the charged particles in the solution.

4. The automatic calibration method for radiopharmaceutical dosage according to claim 1, characterized in that: The method for controlling the injection speed and dosage output using a micro-injection pump and a pressure sensor is as follows: Micro-injection pumps use high-precision stepper motors to drive the syringe piston, precisely controlling the speed and volume of drug injection; The system sets the motor operating parameters according to the predetermined dosage and speed, and adjusts them through real-time feedback to ensure accuracy; Pressure sensors installed in the injection channel monitor fluid flow and help detect abnormalities such as blockages or air bubbles, allowing for timely adjustments to injection parameters.

5. The automatic calibration method for radiopharmaceutical dosage according to claim 1, characterized in that: The laser scattering detection module uses the following method to detect the presence of residual droplets at the tip of the needle in real time: After the injection is completed, the laser scattering detection module is activated when it is necessary to detect whether there are residual droplets at the tip of the needle. The transmitter emits a narrow laser beam that passes through the space at the tip of the needle; If residual droplets are present, the laser beam will be scattered as it passes through the droplets; The receiver is responsible for capturing these changes in scattered light caused by the droplets.

6. The automatic calibration method for radiopharmaceutical dosage according to claim 1, characterized in that: The laser scattering detection module includes a transmitter and a receiver, located on opposite sides of the needle tip.

7. The automatic calibration method for radiopharmaceutical dosage according to claim 1, characterized in that: Methods for determining the volume of residual droplets at the tip of a needle using image recognition algorithms: The images of the needle tip captured by the high-speed camera are processed using image recognition algorithms; Extract the contour information of the residual droplets and calculate their projected area by combining the pixel scale factor; The droplet volume is estimated based on empirical formulas to determine whether a supplemental dose is needed to ensure that the patient receives the accurate amount of medication.

8. The automatic calibration method for radiopharmaceutical dosage according to claim 1, characterized in that: The system calculates the additional dosage that should be supplemented using the following method: The volume of residual droplets at the tip of the needle was determined using laser scattering detection and image recognition technology; Based on the volume of the residual droplets and the characteristics of the radiopharmaceutical, the required supplemental dose is calculated using a built-in algorithm. Adjust the parameters of the microinfusion pump to ensure accurate delivery of the required dose; After replenishment, the tip of the needle is checked again to confirm that there is no residue and to ensure dosage accuracy.

9. The automatic calibration method for radiopharmaceutical dosage according to claim 1, characterized in that: The characteristics of radiopharmaceuticals include, but are not limited to, half-life and electrochemical properties.

10. An automatic calibration method for radiopharmaceutical dosage, based on the calibration method according to any one of claims 1-9, characterized in that, include: The drug preparation and analysis module is used to perform charge state analysis on iodine-131 radiopharmaceutical solutions and determine the polarity and intensity of the static charge. The electrostatic charge application module applies an optimized electrostatic charge to the needle before injection via a microcurrent generator to promote complete drug detachment from the needle. The precision injection control module uses a combination of a micro-injection pump and a pressure sensor to precisely control the injection speed and dosage output, while monitoring abnormal situations during the injection process. The residue detection module includes laser scattering detection and image recognition algorithms to capture and evaluate the volume of residual droplets at the tip of the needle in real time. The dose correction module calculates the additional dose that needs to be supplemented based on the estimated results of residual droplets, ensuring that the patient receives the accurate target dose; The feedback and adjustment mechanism is used to reconfirm that there are no residual droplets at the tip of the needle after supplementing the dose, ensuring the accuracy of the final dosage.

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