A sucralfate wet gel moisturizing gel dressing and a preparation method thereof

Abstract

The present application relates to a kind of sucralfate wet gel moisturizing gel dressings and its preparation method, belong to medical dressing technical field.The dressing contains sucralfate wet gel 3-10 parts, composite moisturizing system 8-15 parts, plant source barrier repair agent 3-8 parts, thickening regulator 1-3 parts and the like by mass fraction, purified water is supplemented to 100 parts;Also contain pH regulator, preservative, spray type additionally add Tween-80.Preparation contains composite moisturizing system and repair agent preparation, gel matrix formation, component mixing, pH adjustment, high pressure homogenization and sterilization and the like step.The dressing can be used for dry dermatitis, medical beauty postoperative skin repair and senile skin dryness care.

Description

Technical Field

[0001] This invention belongs to the field of medical dressing technology, and relates to a sucralfate wet gel moisturizing gel dressing and its preparation method. Background Technology

[0002] Impaired skin barrier function (such as stratum corneum moisture content <10% and loss of sebum film) is the core cause of dry dermatitis, post-cosmetic surgery skin sensitivity, and age-related skin problems.

[0003] Currently, commonly used skin repair products in clinical practice can be divided into two categories: "moisturizing" and "wound protection." Examples include hyaluronic acid gel, ceramide cream, and sucralfate wet gel. While moisturizing products can increase skin hydration through "hydration and moisture retention," they lack wound protection capabilities. For dry skin with minor abrasions (such as cracks or micro-wounds after cosmetic procedures), they cannot isolate external pathogens, making infection more likely. Furthermore, their moisturizing effect is short-lived (skin hydration drops by 50% within 4 hours of application for most products), requiring frequent reapplication. Wound protection products can form a protective film on the skin surface, reducing irritation and infection risks, but they still have drawbacks: weak moisturizing ability—a single sucralfate wet gel formulation cannot meet the moisturizing needs of dry skin; and poor film permeability—prolonged application can lead to stuffy and damp skin, which can actually worsen sensitivity.

[0004] Based on the aforementioned technical deficiencies, there is an urgent need in this field to develop a three-in-one sucralfate wet gel dressing that integrates moisturizing, protection, and repair. This dressing should retain the wound protection capabilities of sucralfate wet gel, possess long-lasting moisturizing properties, promote skin barrier regeneration, and have physicochemical properties suitable for the needs of dry and damaged skin. Summary of the Invention

[0005] The purpose of this invention is to provide a sucralfate wet gel moisturizing dressing and its preparation method, which has excellent breathability, adhesion and storage stability, and is suitable for long-term use on dry and damaged skin.

[0006] The objective of this invention can be achieved through the following technical solutions: A sucralfate wet gel moisturizing dressing, by weight, comprises the following components: 3-10 parts sucralfate wet gel, 8-15 parts composite moisturizing system, 3-8 parts plant-derived barrier repair agent, 1-3 parts thickening regulator, 0.05-0.3 parts pH adjuster, 0.2-0.6 parts preservative, and purified water to the remainder up to 100 parts; The composite moisturizing system consists of 2-5 parts sodium hyaluronate, 2-4 parts polyglutamic acid, 1-3 parts phytosterols, and 3-5 parts glycerin. The plant-derived barrier repair agent is composed of 1-3 parts oat β-glucan, 1-3 parts purslane extract, 0.5-1.5 parts ceramide NP, and 0.5-1.5 parts panthenol; The thickening regulator consists of 1-2 parts hydroxyethyl cellulose and 0.1-0.5 parts transparent xanthan gum.

[0007] As a preferred embodiment of the present invention, the average particle size of the sucralfate wet gel is 5-10 μm and the purity is ≥98%.

[0008] In a preferred embodiment of the present invention, the sodium hyaluronate has a molecular weight of 1.0 × 10⁻⁶. 6 -2.0×10 6 Da.

[0009] In a preferred embodiment of the present invention, the pH adjuster is a lactate-sodium lactate buffer solution, and the preservative is hexanediol.

[0010] As a preferred embodiment of the present invention, the preparation steps of the composite moisturizing system include: Y1. Sodium hyaluronate and polyglutamic acid were dissolved in purified water, with a solid-liquid ratio of 1:20 during dissolution. Y2. Phytosterols are heated to 60°C to melt and then mixed with glycerin to form an oil-phase moisturizing liquid; Y3. Mix sodium hyaluronate solution, polyglutamic acid solution and oil phase moisturizing liquid, add some preservative to obtain a composite moisturizing system.

[0011] As a preferred embodiment of the present invention, the preparation steps of the plant-derived barrier repair agent include: X1. Oat β-glucan was dissolved in purified water, and purslane extract was diluted with purified water; X2. Add ceramide NP and panthenol, stir and dissolve at 40°C, then filter to obtain a plant-derived barrier repair agent solution.

[0012] As a preferred embodiment of the present invention, the dressing is in the form of a gel or a spray. The spray dressing also includes 0.1-0.2 parts of Tween-80 as an atomizing agent.

[0013] As a preferred embodiment of the present invention, the purity of the oat β-glucan is ≥70%.

[0014] A method for preparing the above-described sucralfate wet gel moisturizing dressing is characterized by comprising the following steps: W1. Preparation of a composite moisturizing system; W2. Preparation of plant-derived barrier repair agent solution; W3. Dissolve the thickening regulator in purified water to form the basic gel matrix; W4. Add sucralfate wet gel and disperse evenly; W5. Add the compound moisturizing system and plant-derived barrier repair agent solution in sequence, and stir to mix; W6. Add a pH adjuster to adjust the pH to a range suitable for the skin's physiological environment; W7. High-pressure homogenization at 30℃ and 15-18MPa; W8. Add the remaining preservative, sterilize at 75°C for 20 minutes, cool to 25°C, and obtain the dressing.

[0015] Application of the above-mentioned sucralfate wet gel moisturizing gel dressing in the preparation of products for dry dermatitis, post-medical aesthetic skin repair, and senile dry skin care.

[0016] The beneficial effects of this invention are: (1) The solution of the present invention can achieve the three-in-one function of "moisturizing-protection-repair", retain the wound protection ability of sucralfate wet gel, have long-lasting moisturizing properties, and can also promote skin barrier regeneration.

[0017] (2) The present invention has excellent breathability, adhesion and storage stability, is suitable for the physiological environment of dry and damaged skin, has no irritation with long-term use and has a good application experience.

[0018] (3) The dosage form of the present invention can meet different usage needs, has a wide range of applicable scenarios, solves the single-function defects of existing products, and improves the skin care effect. Detailed Implementation

[0019] To further illustrate the technical means and effects of the present invention in achieving its intended purpose, the following detailed description of the specific implementation methods, structures, features, and effects of the present invention, in conjunction with embodiments, is provided below.

[0020] Some of the raw materials come from the following sources: Polyglutamic acid: Xi'an YaHua Biotechnology Co., Ltd., Product No. YH-20220826911 Oat β-glucan: Shenzhen Boson Biotechnology Co., Ltd., Product No. BS-38 Hydroxyethyl cellulose: Guangzhou Bofeng Chemical Technology Co., Ltd., Product No. 6846521 Transparent xanthan gum: Shanxi HengHua Biotechnology Co., Ltd., Product No. HH-283 Preparation of purslane extract: 1. Place 20kg of fresh purslane into a bubble cleaning machine (water temperature 25℃), introduce 0.1MPa compressed air, and clean for 10 minutes (to remove mud and sand); manually select and remove yellow leaves and weeds, and cut off old roots with scissors (keeping tender stems and leaves); 2. Place the washed purslane in a hot air drying oven and dry at a constant temperature of 60℃ (wind speed 1.2m / s), turning it over once every 2 hours until the moisture content is ≤8% (tested with a rapid moisture analyzer, 5g sample, 105℃); put the dried purslane into an ultra-fine pulverizer, pulverize it and pass it through a 100-mesh standard sieve (sieve aperture 0.15mm), collect the purslane powder (about 5kg), and test the D50 particle size with a laser particle size analyzer to be ≤100μm; 3. In a clean bench, take 10g of *Lactobacillus plantarum* (China Industrial Microbial Culture Collection Center, strain number CICC 20265) freeze-dried bacterial powder, add 1L of sterile MRS medium (sterilized at 121℃ for 20min beforehand, cooled to 37℃), and gently shake to completely dissolve the bacterial powder; transfer the bacterial solution to a 5L Erlenmeyer flask and incubate statically at 37℃ for 24h to obtain primary seed culture (concentration determined by plate count method, ≥1×10⁻⁶). 8 CFU / mL); 4. Take 100 mL of the primary seed culture and inoculate it into a 5 L Erlenmeyer flask containing 900 mL of MRS medium. Continue culturing at 37℃ for 12 h to obtain the secondary seed culture (concentration ≥ 5 × 10⁻⁶). 8 CFU / mL (measured after serial dilution with sterile physiological saline); 5. Add 5 kg of purslane powder and 70 L of purified water to a 50 L fermenter, and start stirring (100 rpm) for 10 min; adjust the pH of the system to 6.0 ± 0.1 with 10% citric acid solution (monitor pH in real time with a pH meter); 6. Add 1L of secondary seed culture to the fermenter through the aseptic inoculation port, seal the tank lid, set the fermentation temperature to 32℃ and the stirring speed to 100rpm; 7. Fermentation process control: For the first 24 hours: Take a 5 mL sample every 6 hours and measure the pH value (it needs to be maintained at 5.5-6.0; if the pH is >6.0, add 10% citric acid; if the pH is <5.5, add 10% sodium hydroxide). 24-48h: Adjust the stirring speed to 80rpm, maintain the temperature at 32℃, and measure the total flavonoid content every 12h (HPLC method, ≥1.5mg / mL); 48h endpoint determination: When the total flavonoid content no longer increases (the difference between two consecutive tests is <5%), fermentation is stopped, and fermentation broth (approximately 75L) is obtained; 8. Primary filtration: Transfer the fermentation broth to a plate and frame filter press and perform vacuum filtration using a 0.22μm PES membrane (operating pressure 0.15MPa, temperature 30℃). Collect the filtrate (approximately 70L) and remove the purslane residue (the residue should be dried and weighed; it must be ≤0.5kg to ensure complete extraction). Fine filtration: Transfer the primary filtrate to a sterile storage tank, add 0.2kg of vitamin C (antioxidant and color-protecting), and stir for 10 minutes to dissolve. Filter again using a 0.1μm PES membrane to remove small particles, obtaining the fine filtrate (approximately 68L). 9. Transfer the filtrate to a rotary evaporator, set the temperature to 50℃, vacuum degree to -0.08MPa, and rotation speed to 80rpm for vacuum concentration; measure the volume every 30 minutes until concentrated to 10L (solid content ≥5%, refractive index ≥1.030 as measured by refractometer); take 10mL of the concentrate and determine the total flavonoid content by HPLC. If the content is <2.0mg / mL, continue concentration; if >2.5mg / mL, dilute with purified water to 2.0-2.5mg / mL to obtain standardized purslane fermentation extract (10kg).

[0021] Example 1 Raw material weighing (by mass): Sucralfate wet gel: 5 portions, average particle size 7 μm (D50 = 7.0 μm), purity 98%; Complex moisturizing system: 12 parts (3 parts sodium hyaluronate, molecular weight 1.5×10⁻⁶) 6 Da, polyglutamic acid (3 parts, molecular weight 8×10) 5 (2 parts Da, 2 parts phytosterols, 4 parts glycerol); Plant-derived barrier repair agent: 6 parts (2 parts oat β-glucan; 2 parts purslane extract; 1 part ceramide NP; 1 part panthenol); Hydroxyethyl cellulose 1.5 parts, transparent xanthan gum 0.3 parts; lactate-sodium lactate buffer 0.2 parts, hexanediol 0.4 parts, purified water 74.6 parts.

[0022] Preparation of the composite moisturizing system: Dissolving sodium hyaluronate: Take 3g of sodium hyaluronate (molecular weight 1.5×10⁻⁶) 6 Add 60g of purified water (1:20) to Da, stir at 25℃ and 300rpm for 30 minutes to form a transparent solution; Polyglutamic acid dissolution: Take 3g of polyglutamic acid, add 60g of purified water (1:20), stir at 25℃ and 300rpm for 30 minutes, and measure the absorbance with a UV spectrophotometer (280nm) to be 1.1±0.05 (completely dissolved); Oil phase preparation: Add 4g glycerol to 2g phytosterol at 60℃ and stir at 500rpm for 5 minutes; Pre-dispersion mixing: The above solution was mixed with the oil phase and stirred at 500 rpm for 15 minutes. 0.1 g of hexanediol was added and stirred for 10 minutes to obtain a 12 g composite moisturizing system.

[0023] Preparation of plant-derived barrier repair agents: Dissolving oat β-glucan: 2g oat β-glucan + 50g purified water, stir at 35℃ and 400rpm for 25 minutes; Purslane extract dilution: 2g extract + 20g purified water, stir for 10 minutes; Compound dissolution: Add 1g ceramide NP and 1g panthenol, stir at 40℃ for 20 minutes, filter through a 0.22μm filter membrane to obtain 6g repair agent solution.

[0024] Overall gel preparation: Thickener dissolution: Heat 746g of purified water at 40℃, add 15g of hydroxyethyl cellulose and 3g of transparent xanthan gum, and stir at 600rpm for 25 minutes; Sucralfate wet gel dispersion: Add 50g sucralfate wet gel (7μm), stir at 800rpm for 30 minutes, and measure D50 with a laser particle size analyzer to be 6.8μm; Active mixing: Add 120g of the complex moisturizing system and 60g of the repair agent solution, and stir to mix; pH adjustment: Add 2g of lactate-sodium lactate buffer solution, pH=5.5; Homogenization and sterilization: Homogenize twice at 30℃ and 15MPa, add 3g of hexanediol, sterilize at 75℃ for 20 minutes, cool to 25℃, and obtain a special gel for medical aesthetic procedures.

[0025] Example 2 Sucralfate moisturizing gel for dry dermatitis Raw material weighing (by mass): Sucralfate wet gel: 3 portions, average particle size 6 μm, purity 98%; Complex moisturizing system: 15 parts (5 parts sodium hyaluronate, molecular weight 1.5×10⁻⁶) 6 (Da, 4 parts polyglutamic acid, 3 parts phytosterol, 3 parts glycerol); Plant-derived barrier repair agent: 8 parts (3 parts oat β-glucan, 3 parts purslane extract, 1.5 parts ceramide NP, 0.5 parts panthenol); 1 part hydroxyethyl cellulose, 0.5 parts transparent xanthan gum, 0.3 parts lactate-sodium lactate buffer, and 0.6 parts hexanediol; Purified water: 68.6 parts.

[0026] Preparation of the composite moisturizing system: Dissolve sodium hyaluronate: 5g (1.5×10) 6Add 100g purified water to Da and stir at 25℃ for 30 minutes. Polyglutamic acid dissolution: 4g + 80g purified water, stir at 25℃ for 30 minutes; Oil phase preparation: 3g phytosterol + 3g glycerol, stir at 60℃ for 5 minutes; Pre-dispersion mixing: After mixing, add 0.1g hexanediol and stir for 10 minutes to obtain 15g of composite moisturizing system.

[0027] Preparation of plant-derived barrier repair agents: Oat β-glucan dissolution: 3g + 75g purified water, stir at 35℃ for 25 minutes; Purslane extract dilution: 3g + 30g purified water, stir for 10 minutes; Compound dissolution: Add 1.5g ceramide NP and 0.5g panthenol, stir at 40℃ for 20 minutes, and filter to obtain 8g of repair agent solution.

[0028] Overall gel preparation: Thickener dissolution: Add 10g hydroxyethyl cellulose and 5g transparent xanthan gum to 686g purified water at 40℃, and stir at 600rpm for 25 minutes; Sucralfate wet gel dispersion: Add 30g sucralfate wet gel, stir at 800rpm for 30 minutes, D50=5.9μm; Active mixing: Add 150g of the complex moisturizing system and 80g of the repair agent solution, and stir; pH adjustment: Add 3g of buffer solution, pH=5.2; Homogenization and sterilization: Homogenize twice at 18MPa and 30℃, add 5g of hexanediol, sterilize at 75℃ for 20 minutes, and cool to obtain sucralfate moisturizing gel for dry dermatitis.

[0029] Example 3 Sucralfate moisturizing gel for dry skin in the elderly Raw material weighing (by mass): Sucralfate wet gel: 8 parts, average particle size 8μm, purity 98%; Complex moisturizing system: 10 parts (2 parts sodium hyaluronate, molecular weight 1.5×10⁻⁶) 6 (Da, 2 parts polyglutamic acid, 1 part phytosterol, 5 parts glycerol); Plant-derived barrier repair agent: 3 parts (1 part oat β-glucan, 1 part purslane extract, 0.5 parts ceramide NP, 0.5 parts panthenol); 2 parts hydroxyethyl cellulose, 0.2 parts transparent xanthan gum, 0.1 parts lactate-sodium lactate buffer, 0.2 parts hexanediol, and 75.5 parts purified water.

[0030] Preparation of the composite moisturizing system: Dissolve sodium hyaluronate: 2g (1.5×10) 6 Add 40g purified water to Da and stir at 25℃ for 30 minutes. Polyglutamic acid dissolution: 2g + 40g purified water, stir at 25℃ for 30 minutes; Oil phase preparation: 1g phytosterol + 5g glycerol, stir at 60℃ for 5 minutes; Pre-dispersion mixing: After mixing, add 0.1g of hexanediol and stir for 10 minutes to obtain 10g of composite moisturizing system.

[0031] Preparation of plant-derived barrier repair agents: Oat β-glucan dissolution: 1g + 25g purified water, stir at 35℃ for 25 minutes; Purslane extract dilution: 1g + 10g purified water, stir for 10 minutes; Compound dissolution: Add 0.5g ceramide NP and 0.5g panthenol, stir at 40℃ for 20 minutes, and filter to obtain 3g repair agent solution.

[0032] Overall gel preparation: Thickener dissolution: Add 20g hydroxyethyl cellulose and 2g transparent xanthan gum to 755g purified water at 40℃, and stir at 600rpm for 25 minutes; Sucralfate wet gel dispersion: Add 80g sucralfate wet gel (8μm), stir at 800rpm for 30 minutes, D50=7.8μm; Active mixing: Add 100g of the complex moisturizing system and 30g of the repair agent solution, and stir; pH adjustment: Add 1g of buffer solution, pH=5.8; Homogenization and sterilization: Homogenize twice at 17MPa and 30℃, add 1g of hexanediol, sterilize at 75℃ for 20 minutes, and cool to obtain sucralfate moisturizing gel for dry skin in the elderly.

[0033] Comparative Example 1 Sucralfate wet gel with an average particle size of 15 μm was selected, and other steps were performed as described in Example 1.

[0034] Comparative Example 2 Select a molecular weight of 0.8 × 10⁻⁶ 6 For Da's sodium hyaluronate, the other steps are the same as in Example 1.

[0035] Comparative Example 3 Replace 12 parts of the compound moisturizing system with 12 parts of glycerin, and refer to Example 1 for other steps.

[0036] Comparative Example 4 The repair agent containing oat β-glucan and purslane extract was replaced with 6 parts of "ceramide NP 3 parts + panthenol 3 parts", and the other steps were the same as in Example 1.

[0037] Comparative Example 5 Replace “1.5 parts hydroxyethyl cellulose + 0.3 parts transparent xanthan gum” with 1.8 parts hydroxyethyl cellulose, and refer to Example 1 for other steps.

[0038] Comparative Example 6 The homogenization temperature was increased to 50°C, and the other steps were the same as in Example 1.

[0039] Comparative Example 7 Use 12 parts of sodium hyaluronate (1.5 × 10⁻⁶) 6 Da) replaces the complex moisturizing system, and the other steps are the same as in Example 1.

[0040] Comparative Example 8 When preparing the plant-derived barrier repair agent, the stirring temperature was increased to 60°C, and other steps were performed as described in Example 1.

[0041] Comparative Example 9 Use 8 parts purified water instead of sucralfate wet gel, and follow the steps in Example 1.

[0042] Performance testing 1. Determination of particle size (D50) and dispersibility of sucralfate wet gel Specific testing methods Instruments: Malvern MS2000 laser particle size analyzer (Hydro 2000MU dispersion unit), Olympus BX53 microscope (400x); Dispersion medium: 0.1% sodium hexametaphosphate aqueous solution (circulating pump 2000rpm, ultrasonic 50W); Procedure: Take 100 μL of gel and drop it into the dispersion medium (10%-15% opacity), measure for 60 seconds / time, repeat 3 times and take the average D50 value; take 5 μL of gel smear and observe the particle aggregation under a microscope (single particles ≥90% are considered uniform dispersion).

[0043] The corresponding test results are shown in Table 1.

[0044] Table 1

[0045] 2. Gel viscosity detection Specific testing methods Instruments: Shanghai Jingtian NDJ-8S rotational viscometer (No.4 rotor), constant temperature water bath (25℃±0.1℃); Operating procedure: Take 30 mL of gel into a 50 mL beaker (≥60 mm), keep it at 25 °C for 10 minutes, and wait for the pointer to stabilize (fluctuation ≤2%) at 6 rpm. Repeat 3 times and take the average. If the viscosity is >5000 mPa·s, replace with rotor No.5. If it is <1000 mPa·s, replace with rotor No.3.

[0046] The corresponding test results are shown in Table 2.

[0047] Table 2

[0048] 3. Moisturizing film integrity test Specific testing methods Materials: Fresh pigskin (2mm thick, 5cm×5cm), 100μm wire bar coater, constant temperature and humidity chamber (25℃ / 60%RH); Operating procedure: Coat a 4cm×4cm pigskin with gel (wet film 100μm), dry for 30 minutes to form a film, observe the film at 2h, 4h, 8h and 24h (50x stereomicroscope), record the damage / detachment, and take the average of 3 pigskins.

[0049] The corresponding test results are shown in Table 3.

[0050] Table 3

[0051] 4.72h Skin Moisture Content Increase Rate Detection Specific testing methods Instrument: CK Corneometer CM825 (±1AU accuracy), Germany; Animal model: SPF grade SD rats (200-220g, with hair removed from the back, 5cm×5cm, 14 groups / 6 rats); Procedure: After fasting for 12 hours, measure the initial water content (average of 3 points), at 0.1 g / cm³. 2 Samples were prepared (purified water was prepared for the blank group), and repeated at 2h, 4h, 8h, 24h, 48h, and 72h. The improvement rate was calculated as (measured value - initial value) / initial value × 100%.

[0052] The corresponding test results are shown in Table 4.

[0053] Table 4

[0054] 5. Moisturizing duration (efficacy improvement after 72 hours of storage) test Specific testing methods Storage conditions: Store in a 25℃ / 60% RH constant temperature and humidity chamber in a sealed transparent bottle (2 / 3 full) for 6 months; Operating procedure: After 6 months, take a sample and equilibrate for 2 hours. Then, retest according to the "72-hour moisture content test" procedure. Calculate the retention rate = (storage enhancement rate / initial enhancement rate) × 100%.

[0055] The corresponding test results are shown in Table 5.

[0056] Table 5

[0057] 6.28-day stratum corneum thickness test Specific testing methods Animal model: SD rat xerosis model (acetone-ether 1:1 wiping 3 times, TEWL≥20g / (m 2 •h)); Operating procedure: Apply 0.1 g / cm² of sample daily. 2 (28 days) After euthanasia, 1cm×1cm skin was taken, fixed in 4% paraformaldehyde for 24h, stained with HE (5μm section), and the thickness was measured in 5 fields of view under a 400x microscope. The thickening rate was calculated as (drug group - blank group) / blank group×100%.

[0058] The corresponding test results are shown in Table 6.

[0059] Table 6

[0060] 7.24h wound infection rate detection Specific testing methods Animal model: Miniature pig micro-injuries (1cm×1cm, 100℃ copper rod pressure for 10 seconds, 18 wounds / group); Operating procedure: Apply 0.1 g / cm² of sample. 2 After bandaging, observe the wound 24 hours later (redness and swelling > 0.5cm, exudation / suppuration indicate infection), and calculate the infection rate = (number of infected wounds / total number of wounds) × 100%.

[0061] The corresponding test results are shown in Table 7.

[0062] Table 7

[0063] 8.6-month active ingredient retention rate test Specific testing methods Instrument: Agilent 1260 HPLC (SB-C18 column 4.6×250mm); Procedure: Plot standard curves for sucralfate wet gel (230 nm, 0.05 mol / L sodium dihydrogen phosphate-acetonitrile 95:5) and sodium hyaluronate (205 nm, methanol-water 70:30); take 1 g of gel and extract by ultrasonication for 30 minutes (300 W), centrifuge (8000 rpm / 10 min), filter through a filter membrane and measure the content, calculate the retention rate = (after storage / initial) × 100%.

[0064] The corresponding test results are shown in Table 8.

[0065] Table 8

[0066] 9. Observation of appearance stability Specific testing methods Observation conditions: 4000 lux fluorescent lamp (30 cm distance), transparent bottle (2 / 3 full of sample), observation at 0 days, 1 month, 3 months and 6 months; Judgment criteria: no layering (clear interface indicates layering), no sedimentation (sedimentation does not disappear when shaken), and no color change (ΔE>2 indicates color change).

[0067] The corresponding test results are shown in Table 9.

[0068] Table 9

[0069] 10. Long-term stimulation (14 days) score Specific testing methods Animal model: SD rats (2cm × 2cm test area on the left and right sides of the back, 0.2g / cm sample on the left side). 2 (Apply purified water to the right side); Scoring criteria: Redness and swelling (0-3 points) + itching (0-3 points) = total score, averaged over 14 days.

[0070] The corresponding test results are shown in Table 10.

[0071] Table 10

[0072] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A sucralfate wet gel moisturizing dressing, characterized in that, By weight, it includes the following components: 3-10 parts sucralfate wet gel, 8-15 parts compound moisturizing system, 3-8 parts plant-derived barrier repair agent, 1-3 parts thickening regulator, 0.05-0.3 parts pH adjuster, 0.2-0.6 parts preservative, and purified water to the remainder of 100 parts; The composite moisturizing system consists of 2-5 parts sodium hyaluronate, 2-4 parts polyglutamic acid, 1-3 parts phytosterols, and 3-5 parts glycerin. The plant-derived barrier repair agent is composed of 1-3 parts oat β-glucan, 1-3 parts purslane extract, 0.5-1.5 parts ceramide NP, and 0.5-1.5 parts panthenol; The thickening regulator is composed of 1-2 parts hydroxyethyl cellulose and 0.1-0.5 parts transparent xanthan gum; The average particle size of the sucralfate wet gel is 5-10 μm, and the purity is ≥98%. The molecular weight of the sodium hyaluronate is 1.0 × 10⁻⁶. 6 -2.0×10 6 Da; The pH adjuster is a lactate-sodium lactate buffer solution, and the preservative is hexanediol.

2. The sucralfate wet gel moisturizing dressing according to claim 1, characterized in that, The purity of the oat β-glucan is ≥70%.

3. The application of the sucralfate wet gel moisturizing gel dressing as described in any one of claims 1-2 in the preparation of products for dry dermatitis, post-medical aesthetic skin repair, and senile dry skin care.

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