Cosmetic containing nicotinamide

Abstract

[Problem] The purpose of the present invention is to provide a cosmetic in which nicotinamide is stably blended in a cosmetic in which an oil component is contained in a microemulsion, and in which the stability of the microemulsion is high. [Solution] A cosmetic according to the present invention, the present invention relates to a cosmetic composition comprising (A) a hydrophilic polyethylene glycol hydrogenated castor oil, (B) a lipophilic polyglycerol fatty acid ester, (C) one or more oil components selected from the group consisting of cetyl ethyl hexanoate, caprylic / capric triglyceride, glycerol tri (ethylhexanoate) ester, pentaerythritol tetra (ethylhexanoate) ester, and diphenylsilyloxyphenyltrimethylsiloxane, and (D) nicotinamide, the oil component is present in the microemulsion, and when the cosmetic contains isostearic acid, the blending amount of isostearic acid is 0.15% by mass or less with respect to the total amount of the cosmetic.

Description

TECHNICAL FIELD

[0001] The present application relates to a cosmetic comprising a microemulsion in which the elution of nicotinamide is inhibited and which has high stability. BACKGROUND

[0002] Nicotinamide (alias: nicotinic acid amide) is known as one of the vitamin B group as a water-soluble vitamin, has high safety, and has a keratolytic effect, a whitening effect, and an anti-wrinkle effect. Therefore, in order to meet the demand for whitening and / or anti-aging by improving wrinkles / sagging, preventing skin roughening, and the like, it is required to incorporate nicotinamide in cosmetics of various dosage forms.

[0003] A liquid cosmetic in which oil components are microparticulated and incorporated has the advantage that it can widely achieve a use touch and a skin improvement effect in accordance with preference, since it imparts a gentle touch to the skin and exhibits high permeability to the skin.

[0004] Patent Document 1 discloses a liquid cosmetic which is translucent to transparent in appearance, in which oil components are microparticulated, and which is described as being capable of obtaining a cosmetic which is excellent in long-term stability and vibration stability, by incorporating (a) 0.01 to 3% by weight of oil components in which a branched-chain saturated fatty acid accounts for 1.0 to 80.0% by weight, which is liquid at ordinary temperatures, and (b) a hydrophilic surfactant.

[0005] As the branched-chain saturated fatty acid which is a necessary component of the invention of Patent Document 1, isostearic acid is preferably used, but in the course of research by the present inventors and the like, there was a problem that elution of nicotinamide occurred when nicotinamide was incorporated in a cosmetic in which oil components containing isostearic acid were microparticulated and contained in an aqueous medium.

[0006] PRIOR ART DOCUMENTS

[0007] PATENT DOCUMENTS

[0008] Patent Document 1: Japanese Patent No. 4160264 SUMMARY

[0009] PROBLEMS TO BE SOLVED BY THE INVENTION

[0010] An object of the present application is to provide a cosmetic in which nicotinamide is stably incorporated in a cosmetic in which oil components are present in a microemulsion, and the microemulsion has high stability.

[0011] The present inventors and the like repeatedly conducted intensive research in order to solve the above problem, and as a result, found that in a cosmetic in which oil components are contained in a microemulsion, by using a hydrophilic polyethylene glycol hydrogenated castor oil, a lipophilic polyglycerin fatty acid ester, and a specific oil component, it is possible to obtain a cosmetic in which elution of nicotinamide incorporated in an aqueous medium is inhibited, and the microemulsion has high stability, and completed the present application.

[0012] That is, the present application provides a cosmetic comprising:

[0013] (A) a hydrophilic polyethylene glycol hydrogenated castor oil;

[0014] (B) a lipophilic polyglyceryl fatty acid ester;

[0015] (C) one or more oil components selected from the group consisting of cetyl ethylhexanoate, caprylic acid / capric acid triglyceride, glyceryl tri (ethylhexanoate), pentaerythritol tetra (ethylhexanoate), and diphenylsilyloxyphenyl trimethicone; and

[0016] (D) nicotinamide,

[0017] and the oil components are present in the microemulsion,

[0018] In the case where the cosmetic contains isostearic acid, the amount of isostearic acid is 0.15% by mass or less relative to the total amount of the cosmetic.

[0019] Effects of the Invention

[0020] The present application, by being configured as described above, can provide a cosmetic in which the deposition of nicotinamide is inhibited and the stability of the microemulsion is high, in a cosmetic containing oil components in a microemulsion. DETAILED DESCRIPTION

[0021] The cosmetic of the present application is characterized by containing (A) a hydrophilic polyethylene glycol hydrogenated castor oil, (B) a lipophilic polyglyceryl fatty acid ester, (C) a specific oil component, and (D) nicotinamide. Hereinafter, each component constituting the cosmetic of the present application is described in detail.

[0022] < (A) Hydrophilic polyethylene glycol hydrogenated castor oil >

[0023] The (A) hydrophilic polyethylene glycol hydrogenated castor oil (hereinafter sometimes referred to simply as "(A) component") of the present application refers to a nonionic surfactant classified as a polyoxyethylene hydrogenated castor oil of oxyethylene condensation type having an HLB of 10 or more. Among them, it is preferable that the average oxyethylene addition mole number be 30 to 60 and the HLB be 11 to 14. As specific examples, PEG-30 hydrogenated castor oil (HLB = 11), PEG-40 hydrogenated castor oil (HLB = 12), and PEG-60 hydrogenated castor oil (HLB = 14), etc. can be listed, with PEG-60 hydrogenated castor oil (HLB = 14) being preferable. As commercially available products, NIKKOL HCO-30, NIKKOL HCO-40, and NIKKOL HCO-60 (manufactured by Nikko Chemicals Co., Ltd.), etc. can be listed.

[0024] The blending amount of the (A) component in the cosmetic of the present application is preferably 0.05 to 3 mass%, more preferably 0.1 to 2 mass%, and further preferably 0.2 to 1 mass% relative to the total amount of the cosmetic. When it is less than 0.05 mass%, it is sometimes difficult to form a stable microemulsion, and when it exceeds 3 mass%, stickiness is sometimes generated.

[0025] < (B) lipophilic polyglyceryl fatty acid ester >

[0026] The (B) lipophilic polyglyceryl fatty acid ester (hereinafter sometimes simply referred to as "(B) component") of the present application refers to a substance in which a fatty acid is ester-bonded to the hydroxyl group of polyglycerol obtained by dehydration polymerization of glycerol, and the HLB is 8 or less. Among them, polyglyceryl-2 diisostearate having HLB = 3 to 6.5 is preferable. As commercially available products, Matsumate DI, Matsumate MI-220, WOGEL-18DV (manufactured by Matsumoto Fine Chemical Co., Ltd.), EMULEX DISG-2 (manufactured by NIHON EMULSION Co., Ltd.), EMULEX DISG-2EX (manufactured by NIHON EMULSION Co., Ltd.), S face IS-202P (manufactured by Sakamoto Yakuhin Kogyo Co., Ltd.), and the like can be listed.

[0027] The blending amount of the (B) component in the cosmetic of the present application is preferably 0.05 to 2 mass%, more preferably 0.08 to 1.5 mass%, and further preferably 0.1 to 1 mass% relative to the total amount of the cosmetic. When it is less than 0.05 mass%, it is sometimes difficult to form a stable microemulsion, and when it exceeds 2 mass%, stickiness is sometimes generated.

[0028] In the cosmetic of the present application, from the viewpoint of improving the stability of the microemulsion over time, the blending ratio of the above-mentioned (A) hydrophilic polyethylene glycol hydrogenated castor oil to the above-mentioned (B) lipophilic polyglyceryl fatty acid ester ((A) / (B)) is preferably 1.6 to 7 in terms of mass ratio, and further preferably 4 to 7.

[0029] < (C) specific oil component >

[0030] The (C) specific oil component (hereinafter, sometimes simply referred to as "(C) component") of the present application is one or more oil components selected from the group consisting of cetyl alcohol ethylhexanoate, caprylic acid / capric acid triglyceride, glycerin tri (ethylhexanoate), pentaerythritol tetra (ethylhexanoate), and diphenylsilyloxyphenyl trimethicone.

[0031] The blending amount of the (C) component in the cosmetic of the present application is preferably 0.05 to 2% by mass, more preferably 0.08 to 1.5% by mass, and further preferably 0.1 to 1% by mass, relative to the total amount of the cosmetic. When it is less than 0.05% by mass, the mild touch on the skin and / or the use touch in accordance with the preference are sometimes impaired, and when it exceeds 2% by mass, stickiness is sometimes generated.

[0032] < (D) Nicotinamide >

[0033] The (D) nicotinamide (hereinafter, sometimes simply referred to as "(D) component") of the present application is an amide compound of nicotinic acid (also referred to as vitamin B3 or niacin). Nicotinamide is a water-soluble vitamin, and is a substance widely known as one of the vitamin B group, and can be obtained by extraction from natural products such as rice bran, or by synthesis using a publicly known method.

[0034] The blending amount of the (D) component in the cosmetic of the present application is not particularly limited, and is preferably 0.01 to 10% by mass, more preferably 0.03 to 8% by mass, and further preferably 0.04 to 6% by mass, relative to the total amount of the cosmetic. If it is blended within the above range, the keratosis-improving effect, whitening effect, and anti-wrinkle action of nicotinamide, and the like can be felt in terms of improvement of wrinkles / sagging, and prevention of rough skin.

[0035] The cosmetic of the present application is a liquid cosmetic containing a microemulsion (microparticle) in an aqueous medium, the microemulsion being formed by solubilizing an oil component in the vicinity of a lipophilic group inside a micelle formed of the above-mentioned (A) hydrophilic polyethylene glycol hydrogenated castor oil. That is, the cosmetic of the present application has a feature that the oil component is soluble in the microemulsion. The microemulsion cosmetic of the present application is a system in thermodynamic equilibrium, unlike an emulsified solution. The microemulsion in the present specification refers to a fine droplet containing an oil component, and the particle diameter is 100 nm or less.

[0036] In the cosmetic of the present application containing nicotinamide, if isostearic acid is blended in the oil component, precipitation of nicotinamide sometimes occurs. The blending amount of isostearic acid in which precipitation of nicotinamide occurs varies depending on the blending amount of nicotinamide. In the case where isostearic acid is blended in the cosmetic of the present application, it is preferable that the product of the value after adding 0.005 to the blending amount (mass%) of isostearic acid relative to the total amount of the cosmetic (P) and the blending amount (mass%) of nicotinamide (Q) [ (P + 0.005) x Q] be 0.075 or less. For example, from the viewpoint of sufficiently suppressing the precipitation of nicotinamide, the blending amount of isostearic acid is preferably set to 0.15% by mass or less relative to the total amount of the cosmetic.

[0037] The cosmetic of the present application can contain an oil component other than the above-mentioned (C) component. As the oil component other than the above-mentioned (C) component, an oil component conventionally used in cosmetics and the like can be selected without particular limitation. For example, there can be mentioned greases, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, ester oils, silicone oils, and oil-soluble medicaments.

[0038] As specific examples, there can be mentioned avocado oil, camellia seed oil, turtle oil, macadamia nut oil, corn oil, mink oil, oil olive fruit oil, rapeseed oil, egg yolk oil, sesame oil, apricot kernel oil, wheat germ oil, camellia flower oil, castor bean oil, flaxseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, tung oil, Japanese tung oil, jojoba seed oil, germ oil, triisooctanoic acid glycerin ester, triisopalmityl glycerin ester, isopropyl hexyl isopalmitate, isopropyl isostearate, isostearyl isostearate, isocetyl isostearate, hexyl isostearate, myristyl stearate, isocetyl octanoate, cetyl isooctanoate, isostearyl ethylhexanoate, isodecyl isononanoate, octyldodecyl dimethyl octanoate, oleyl myristate, isostearyl erucate, isocetyl stearate, ethylhexyl stearate, isostearyl palmitate, isocetyl palmitate, ethylhexyl palmitate, isostearyl myristate, isocetyl myristate, octyldodecyl myristate, decyl myristate, isopropyl palmitate, isopropyl myristate, trimethylolpropane triisostearate, neopentyl glycol dicaprate, diethylhexyl sebacate, octyldodecyl 12-stearyloxy stearate, dioctyldodecyl stearoyl glutamate, diethylhexyl adipate, diisostearyl malate, ethylhexyl methoxycinnamate, octyldodecyl lactate, isostearyl lactate, octyl p-dimethylaminobenzoate, liquid paraffin, squalane, isoparaffin, alpha-olefin oligomer, polybutene, volatile cyclic silicone, volatile dimethylpolysiloxane, methylphenyl silicone, oleyl alcohol, 2-octyldodecanol, cocoa seed fat, coconut oil, horse fat, hydrogenated coconut oil, oil palm oil, beef fat, mutton fat, hydrogenated beef fat, oil palm kernel oil, lard, beef bone fat, candlenut wax kernel oil, hydrogenated oil, beef hoof oil, candlenut wax, hydrogenated castor oil, beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, Chinese wax, whale wax, montan wax, rice bran wax, lanolin, kapok wax, acetylated lanolin, lanolin oil, sugar cane wax, isopropyl lanolate, hexyl laurate, hydrogenated lanolin, jojoba wax, hard lanolin, shellac wax, cholestanol, phytostanol, microcrystalline wax, behenyl alcohol, stearyl alcohol, cetyl alcohol, behenic acid, stearic acid, isostearic acid, oleic acid, myristic acid, and the like. These can be used singly or in combination of two or more.

[0039] In addition, the cosmetic of the present application can be appropriately blended with various components generally used in cosmetics, within a range not impeding the effects of the present application, in addition to the above components.Specific examples include glycols such as propylene glycol, dipropylene glycol, 1,3-butanediol, 1,4-butanediol, diethylene glycol, triethylene glycol, and polyethylene glycol; glycerols such as glycerol, diglycerol, and polyglycerol; sugar alcohols such as sorbitol, mannitol, maltitol, xylitol, and erythritol; sugars such as fructose, glucose, galactose, maltose, lactose, and trehalose; inorganic powders such as talc, kaolin, mica, silica, and zeolite; organic powders such as polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, and cellulose powder; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red iron oxide); and iron oxide yellow. Inorganic yellow pigments such as ochre and yellow ochre; inorganic black pigments such as iron oxide black and carbon black; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and Prussian blue; pearlescent pigments such as titanium oxide coated mica, colored titanium oxide coated mica, bismuth oxychloride, and fish scale foil; metallic powder pigments such as aluminum powder and copper powder; organic pigments such as Red 201, Red 202, Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, and Blue 404; Red 3, Red 104, Red 106, Red 227, Red 230, and Red 401. Organic pigments such as zirconium, barium, or aluminum lakes, including Red 505, Orange 205, Yellow 4, Yellow 5, Yellow 202, Yellow 203, Green 3, and Blue 1; natural pigments such as chlorophyll and β-carotene; plant-based polymers such as gum arabic, tragacanth, galactomannan, guar gum, carob gum, black privet gum, gellan gum, and carrageenan gum; microbial polymers such as xanthan gum, dextran, succinyl dextran, and budding stalk polysaccharide; animal-based polymers such as collagen, casein, albumin, and gelatin; starch-based polymers such as carboxymethyl starch and methyl hydroxypropyl starch; methyl cellulose, ethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, sodium carboxymethyl cellulose, and cellulose... Cellulose-based polymers such as crystalline cellulose; alginate-based polymers such as sodium alginate and propylene glycol alginate; vinyl-based polymers such as polyvinyl alcohol, polyvinyl acetate, polyvinyl methyl ether, polyvinylpyrrolidone, vinylpyrrolidone-vinyl acetate copolymer, and carboxyvinyl polymers; acrylic-based polymers such as sodium polyacrylate, polyethyl polyacrylate, polyalkylolamine polyacrylate, alkyl methacrylate-dimethylaminoethyl methacrylate copolymer, poly-2-acrylamide-2-methylpropanesulfonic acid, and polymethacryloyloxytrimethylammonium; vitamins such as vitamin B6 hydrochloride and panthenol ether; pharmaceuticals such as ultraviolet absorbers, chelating agents, bactericides, anti-inflammatory agents, preservatives, plant extracts, amino acids, and cooling agents; and lower alcohols such as ethanol and isopropanol.

[0040] The cosmetic of the present application can be used as a sunscreen base, a suntan base, a cleansing base, in addition to being used as a skin care cosmetic water, a beauty liquid, and the like. Among these, use as a cosmetic water is particularly preferred.

[0041] The cosmetic of the present application can be manufactured according to the methods generally used in cosmetics containing oil components in microparticles (microemulsions). Specifically, an aqueous phase is prepared by dissolving water-soluble components in water, and water-insoluble components such as oil components are mixed with amphiphilic components (surfactants), which are added to the aqueous phase and stirred.

[0042] Examples

[0043] The present application is further described in detail by the following examples, but the present application is not limited by any of these examples. The amounts of the components are expressed in mass % relative to the entire cosmetic, unless otherwise specified. Before the specific description of each example, the evaluation methods used are described.

[0044] 1. Precipitation of nicotinamide

[0045] The cosmetic of each example was prepared, and the appearance was observed visually and with a microscope to confirm the presence or absence of a precipitate. In cases where a precipitate was found, it was determined that precipitation of nicotinamide had occurred.

[0046] 2. Stability of microemulsion

[0047] For each of the prepared cosmetics, the L value was measured using a color difference meter SE7700 (manufactured by Nippon Denshoku Industries Co., Ltd.) immediately after preparation and after 4 weeks at 50°C, and the values were compared. The L value (value of L in the Lab color system) is an index of turbidity, and is a value determined when the transparency when light is passed through is set to 100 and the transparency when light is completely blocked and no light is transmitted is set to 0, with 5 ml of purified water added to a disposable cell. A decrease in the L value over time indicates that the stability of the microemulsion is impaired.

[0048] < Evaluation Criteria >

[0049] A: The decrease in the L value after 4 weeks was 1 or less compared to immediately after preparation.

[0050] B: The decrease in the L value after 4 weeks was more than 1 and less than 10 compared to immediately after preparation.

[0051] C: The decrease in the L value after 4 weeks was 10 or more compared to immediately after preparation.

[0052] D: Strong turbidity occurred immediately after preparation.

[0053] (Examples and Comparative Examples)

[0054] Cosmetics having the compositions shown in Tables 1 to 3 below were prepared. Specifically, an aqueous component containing the (D) component in the table was stirred and dissolved to prepare an aqueous phase, and a mixed solution of the (A) component and an oil component obtained by uniformly dissolving the oil-soluble components separately was added to the aqueous phase while stirring, whereby the cosmetics were prepared. For the prepared cosmetics, the evaluation of the elution of nicotinamide and the stability of the microemulsion was performed according to the above evaluation methods. The results are shown in the tables.

[0055] [Table 1]

[0056]

[0057] Examples 1 to 8 shown in Table 1 are examples in which the mixing ratio of the (A) component to the (B) component was varied, and Example 9 is an example in which the mixing amount of the (D) component was increased. In any of the examples, the elution of nicotinamide did not occur in the case where the (A) to (D) components of the present application were contained. In the cosmetics of Examples 1 to 9, the cosmetics of Example 6 in which the mixing ratio [ (A) / (B) ] of the (A) component to the (B) component was 1 and the cosmetics of Example 7 in which the mixing ratio was 0.6 showed a tendency that the stability of the microemulsion was poor, but the cosmetics of Examples 1 to 5, 8, and 9 in which the mixing ratio of the (A) component to the (B) component was 1.67 to 7 also showed excellent stability of the microemulsion.

[0058] [Table 2]

[0059]

[0060] Examples 8 and 10 to 13 shown in Table 2 are examples in which one kind was selected from the (C) components and mixed. In any of the examples, the elution of nicotinamide did not occur, and the stability of the microemulsion was also excellent.

[0061] On the other hand, Comparative Examples 1 and 2 are examples in which microemulsion cosmetics were prepared by attempting to use other oil components instead of the (C) component of the present application. The cosmetics of these comparative examples showed strong opalescence immediately after preparation, and stable microemulsions could not be obtained.

[0062] [Table 3]

[0063]

[0064] As shown in Table 3, the cosmetics of Example 14 in which 0.12 mass% of isostearic acid was contained in the oil component with respect to 0.05 mass% of the (D) nicotinamide, the cosmetics of Example 15 in which 0.005 mass% of isostearic acid was contained in the oil component with respect to 5 mass% of the (D) nicotinamide, and the cosmetics of Example 9 which did not contain isostearic acid did not show the elution of nicotinamide.

[0065] On the other hand, Comparative Examples 3 and 4 are conventional microemulsion-type cosmetics prepared using isostearic acid described in Patent Document 1 in place of the component (C). When the component (D) niacinamide is incorporated in the conventional cosmetics, precipitation of the niacinamide occurs. In addition, Comparative Example 5 is a microemulsion-type cosmetic prepared using the components (A) to (C) of the present application, but when 0.18 mass% of isostearic acid is contained in the oil component with respect to 5 mass% of the component (D) niacinamide, precipitation of the niacinamide occurs.

[0066] Therefore, in the case where isostearic acid is incorporated in the cosmetic of the present application containing the component (D) niacinamide, the incorporation amount P of isostearic acid with respect to the total amount of the cosmetic is preferably 0.15 mass% or less, and the product [(P + 0.005) x Q] of the value obtained by adding 0.005 to the incorporation amount (mass%) P of isostearic acid with respect to the total amount of the cosmetic plus the incorporation amount (mass%) Q of the component (D) niacinamide is further preferably 0.075 or less.

Claims

1. A cosmetic comprising: (A) a hydrophilic polyethylene glycol hydrogenated castor oil, (B) an oleophilic polyglyceryl fatty acid ester, (C) one or more oil components selected from the group consisting of cetyl alcohol ethylhexanoate, caprylic acid / capric acid triglyceride, glycerin tri (ethylhexanoate), pentaerythritol tetra (ethylhexanoate), and diphenylsilyloxyphenyl trimethicone, and (D) nicotinamide, and the oil components are present in a microemulsion, in the case where the cosmetic contains isostearic acid, the amount of isostearic acid is 0.15% by mass or less relative to the total amount of the cosmetic.

2. The cosmetic according to claim 1, wherein The blending ratio of the (A) component to the (B) component ((A) / (B) ) is 1.6 to 7 by mass ratio.

3. The cosmetic according to claim 1, wherein The amount of the (D) component is 0.01 to 10% by mass relative to the total amount of the cosmetic.

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