Traditional Chinese medicine preparation with divaricate saposhnikovia root and cough relieving effects and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine preparation with radix saposhnikoviae and cough relieving effects and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine preparation is prepared from 11 traditional Chinese medicines including radix saposhnikoviae, herba schizonepetae, herba menthae, semen oroxyli, radix glycyrrhizae, cortex dictamni, flos mume, honey-fried flos farfarae, fructus nandinae, radix platycodonis and roasted fructus chebulae. The preparation method comprises the following steps: distilling to extract volatile oil, decocting dregs and other medicinal materials with water, filtering, concentrating, adding auxiliary materials, granulating, drying, spraying the volatile oil, and uniformly mixing to prepare granules. The preparation can dispel wind and relieve exterior syndrome, clear away lung-heat and relieve sore-throat, relieve cough and reduce sputum and quickly relieve core symptoms such as throat itching and instant cough aiming at wind cough caused by wind evil invading lung and lung qi dispersing, is quick in effect taking and exact in curative effect, solves the problems that an existing preparation is not high in pertinence and easy to relapse, is suitable for related diseases such as cough after cold, and provides a new traditional Chinese medicine choice for wind cough treatment.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparation technology, specifically to a traditional Chinese medicine preparation with antitussive and cough-relieving effects and its preparation method. Background Technology

[0002] Cough is one of the most common respiratory symptoms in clinical practice, often caused by external or internal factors leading to impaired lung function and upward flow of lung qi. Among these, "wind cough," caused by wind invading the lungs, is particularly prevalent, characterized by paroxysmal coughing, coughing upon throat itching, rapid coughing, and exacerbation by cold air or irritants. In modern medicine, this condition is often associated with post-cold cough, cough-variant asthma, and allergic cough.

[0003] Currently, Western medicine primarily uses antitussives, antihistamines, bronchodilators, and corticosteroids for the clinical treatment of cough. While these medications can relieve symptoms relatively quickly, they often fail to address the root cause, are prone to relapse, and have significant side effects (such as drowsiness, dry mouth, and drug dependence). The long-term efficacy is particularly unsatisfactory for chronic or allergic coughs.

[0004] In the field of traditional Chinese medicine, there is an abundance of medicinal resources for relieving cough and phlegm, and a large amount of research and clinical application have been conducted. For example: Bitter almond: bitter and warm, it is good at lowering lung qi, relieving cough and asthma, but its efficacy is relatively weak when used alone, and it contains trace amounts of hydrocyanic acid, so it should not be used in excessive amounts. Platycodon grandiflorus: it clears the lungs and soothes the throat, eliminates phlegm and drains pus, and is good at opening up lung qi. It is effective for cough with excessive phlegm and sore throat, but its cough-relieving effect is slow, and it is not very targeted at the key symptom of wind-cough, which is itchy throat. Aster tataricus and coltsfoot flower: both are good medicines for moistening the lungs, lowering qi, eliminating phlegm and relieving cough. They are often used together, but they are mainly for cough with phlegm. For wind-cough characterized by itchy throat and dry cough, their wind-dispelling and spasm-relieving effects are insufficient.

[0005] While there are many existing compound cough-relieving Chinese medicine preparations, such as Tongxuan Lifei Pills, Jizhi Syrup, and Qiangli Loquat Syrup, most of these preparations are designed for coughs caused by wind-cold, wind-heat, or phlegm-heat. They either focus on relieving exterior syndromes with pungent and warm herbs, dispersing lung qi and cold, or on clearing heat and resolving phlegm. Their formulation and drug combinations are not specifically aimed at the core pathogenesis of wind-cough: "wind-evil invading the lungs, impaired lung qi circulation, and airway spasm." Therefore, in clinical applications, it has been found that existing preparations often have limited effectiveness against the core symptom of wind-cough: "itchy throat triggers cough, which is difficult to suppress," and suffer from problems such as slow onset of action, weak targeting, and easy recurrence.

[0006] In summary, current technologies lack a specific traditional Chinese medicine preparation that targets the pathogenesis of "wind-cough," effectively dispelling wind and relieving spasms, promoting lung qi, and rapidly alleviating symptoms such as itchy throat and severe cough. Developing a well-formulated, effective, and low-side-effect traditional Chinese medicine preparation that can fill the current market gap for preventing wind-cough has become an urgent clinical need and is of significant practical importance in meeting the health needs of a large number of patients.

[0007] It should be noted that the information disclosed in the background section above is only used to enhance the understanding of the background of this disclosure, and therefore may include information that does not constitute prior art known to those skilled in the art. Summary of the Invention

[0008] The purpose of this invention is to provide a traditional Chinese medicine preparation with the effect of preventing wind and relieving cough, thus providing a traditional Chinese medicine preparation resource with definite efficacy for preventing wind and relieving cough.

[0009] To achieve the above objectives, the present invention provides a traditional Chinese medicine formula with the effects of preventing wind and relieving cough, comprising Saposhnikovia divaricata, Schizonepeta tenuifolia, Mentha haplocalyx, Oroxylum indicum, Glycyrrhiza uralensis, Dictamnus dasycarpus, Prunus mume, honey-processed Tussilago farfara, Dendrobium nobile, Platycodon grandiflorus, and Terminalia chebula.

[0010] Preferably, the above-mentioned traditional Chinese medicine formula is made from the following raw materials in parts by weight: 1-20 parts of Saposhnikovia divaricata, 1-20 parts of Schizonepeta tenuifolia, 1-11 parts of Mentha haplocalyx, 1-14 parts of Oroxylum indicum, 1-11 parts of Glycyrrhiza uralensis, 1-15 parts of Dictamnus dasycarpus, 1-14 parts of Prunus mume, 1-14 parts of honey-processed Tussilago farfara, 1-11 parts of Dendrobium nobile, 1-11 parts of Platycodon grandiflorus, and 1-11 parts of roasted Terminalia chebula.

[0011] Preferably, the weight parts of each ingredient in the above-mentioned traditional Chinese medicine formula are as follows: 10-20 parts of Saposhnikovia divaricata, 10-20 parts of Schizonepeta tenuifolia, 5-11 parts of Mentha haplocalyx, 7-14 parts of Oroxylum indicum, 5-11 parts of Glycyrrhiza uralensis, 7-15 parts of Dictamnus dasycarpus, 7-14 parts of Prunus mume, 7-14 parts of honey-processed Tussilago farfara, 5-11 parts of Dendrobium nobile, 5-11 parts of Platycodon grandiflorus, and 5-11 parts of roasted Terminalia chebula.

[0012] Preferably, the weight parts of each raw material in the above-mentioned traditional Chinese medicine formula are as follows: 15 parts of Saposhnikovia divaricata, 15 parts of Schizonepeta tenuifolia, 8 parts of Mentha haplocalyx, 10 parts of Oroxylum indicum, 8 parts of Glycyrrhiza uralensis, 10 parts of Dictamnus dasycarpus, 10 parts of Prunus mume, 10 parts of honey-processed Tussilago farfara, 8 parts of Dendrobium nobile, 8 parts of Platycodon grandiflorus, and 8 parts of roasted Terminalia chebula.

[0013] The traditional Chinese medicine formula provided by this invention can be used in the preparation of traditional Chinese medicine preparations with the effects of preventing wind and relieving cough.

[0014] The present invention also provides a traditional Chinese medicine preparation made from the above-mentioned traditional Chinese medicine formula.

[0015] This invention also provides a method for preparing a traditional Chinese medicine preparation with antitussive and cough-relieving effects, comprising the following steps: S1: Soak Saposhnikovia divaricata, Schizonepeta tenuifolia, and Mentha haplocalyx in warm water, then distill to extract the volatile oil for later use; S2: Boil the dregs after extracting the volatile oil with the remaining eight medicinal materials in water, filter, combine the filtrates, and concentrate into a thick paste; S3: Add dextrin to the thick paste, granulate, and dry; S4: Spray in the prepared volatile oil, mix well, and store in a sealed container to obtain granules.

[0016] Furthermore, in step S1 of the above preparation method, the soaking temperature is 40℃-50℃ and the time is 1-2 hours.

[0017] Furthermore, in step S2 of the above preparation method, the decoction is performed twice, for 1 hour each time.

[0018] Furthermore, in steps S1 and S2 of the above preparation method, the amount of water added is 10 times the weight of the raw materials.

[0019] The traditional Chinese medicine preparation provided by this invention primarily treats wind-heat, relieving exterior symptoms, and clearing the lungs to stop coughing. Following the traditional theory of principal, assistant, and adjuvant herbs, the formula can be composed as follows: Saposhnikovia divaricata and Schizonepeta tenuifolia are the principal herbs, excelling at relieving wind-heat, eliminating dampness, and relieving pain. They target the main causes of wind-evil invading the exterior and impaired lung function, opening the pores to expel the pathogen. Mentha haplocalyx, Oroxylum indicum, honey-processed Tussilago farfara, Dendrobium nobile, and Platycodon grandiflorus are the assistant herbs. Mentha haplocalyx assists the principal herbs in dispersing wind-heat and clearing the throat; Oroxylum indicum clears the lungs and throat, soothes the liver and stomach; Tussilago farfara and Dendrobium nobile moisten the lungs, lower qi, clear heat, and resolve phlegm; Platycodon grandiflorus clears the lungs and throat, eliminates phlegm, and drains pus, working synergistically with the principal herbs. It enhances the effects of clearing the lungs and relieving cough, soothing the throat and relieving itching, directly targeting the main symptoms such as cough, sore throat, and itchy throat. Dictamnus dasycarpus root bark, plum blossom, and licorice are used as adjuvant herbs. Dictamnus dasycarpus root bark clears heat and dries dampness, dispels wind and detoxifies, and also addresses the accompanying symptoms of skin itching, damp heat, or allergies. Plum blossom soothes the liver and relieves depression, harmonizes the middle jiao and resolves phlegm, and regulates the qi mechanism to assist the lungs in respiration. Licorice can clear heat and detoxify, resolve phlegm and relieve cough, and also harmonize the other herbs and mitigate the drying and pungent nature of other herbs. Terminalia chebula fruit is used as the guiding herb, which is good at astringing the lungs and relieving cough, and astringing the intestines and stopping diarrhea. It can prevent the pungent and dispersing herbs from consuming lung qi and body fluids, and can also guide the medicine into the lung system, while also regulating the balance of lung qi. The formula combines warm and cool properties, promotes both dispersing and astringent effects, and harmonizes the lungs and liver. It targets the core pathogenesis of wind-evil attacking the exterior and impairing the lungs' ability to disperse and purify, while also addressing concurrent symptoms such as relieving cough and phlegm, anti-allergy, and soothing the liver and throat. Together, it achieves the effects of dispelling wind and relieving exterior symptoms, clearing the lungs and throat, and relieving cough and phlegm.

[0020] The present invention has the following advantages: This invention provides a novel traditional Chinese medicine formula that follows the principles of monarch, minister, assistant, and guide, combining pungent and warm herbs with pungent and cool herbs, and balancing dispersing and astringing effects. It both expels pathogens and protects the lungs, avoiding the limitations of single treatment methods. The prepared traditional Chinese medicine preparation, combined with clinical use and efficacy follow-up, shows that most patients with wind-cold cough experience symptom relief within 2 days and can be cured within 1 week, with a low recurrence rate. It is characterized by rapid onset of action and high cure rate, enriching the drug resource library for relieving asthma and cough. Detailed Implementation

[0021] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0022] Note: Unless otherwise specified, the experimental methods in the following examples are conventional methods, performed according to the techniques or conditions described in the literature in this field or according to the product instructions. Unless otherwise specified, the materials and reagents used in the following examples are commercially available.

[0023] Example 1 This embodiment provides a traditional Chinese medicine preparation with wind-preventing and cough-relieving effects, the components and preparation process of which are as follows: 1. Preparation of raw materials: The raw materials were accurately weighed according to the following proportions: 15 parts of Saposhnikovia divaricata, 15 parts of Schizonepeta tenuifolia, 8 parts of Mentha haplocalyx, 10 parts of Oroxylum indicum, 8 parts of Glycyrrhiza uralensis, 10 parts of Dictamnus dasycarpus, 10 parts of Prunus mume, 10 parts of honey-processed Tussilago farfara, 8 parts of Dendrobium nobile, 8 parts of Platycodon grandiflorus, and 8 parts of Terminalia chebula. All raw materials met the standards for the corresponding medicinal materials in Part I of the 2020 edition of the Chinese Pharmacopoeia.

[0024] 2. Preparation method: Warm soaking and volatile oil extraction: According to the prepared raw materials, add water at 10 times the volume of water and soak at 40℃-50℃ for 1-2 hours, then distill to extract the volatile oil and set aside. Decoction and filtration: Put the distilled dregs and the other 8 medicinal materials, including wood orchid, licorice, into a decoction pot, add water and decoct twice, one hour each time. Filter the decoction and combine the filtrates. Add 10 times the amount of water each time you decoct. Concentration and Granulation: The concentrated and combined filtrate is granulated after adding dextrin according to conventional granulation methods; Injecting volatile oil: Inject the extracted volatile oil, mix well, and seal for 24 hours to obtain the finished traditional Chinese medicine preparation. Package into 10g bags.

[0025] Example 2 This embodiment also provides a traditional Chinese medicine preparation with wind-preventing and cough-relieving effects, the components of which are as follows: 1. Preparation of raw materials: Accurately weigh the following ingredients by weight: 10 parts Saposhnikovia divaricata, 10 parts Schizonepeta tenuifolia, 5 parts Mentha haplocalyx, 7 parts Oroxylum indicum, 5 parts Glycyrrhiza uralensis, 7 parts Dictamnus dasycarpus, 7 parts Prunus mume, 7 parts honey-processed Tussilago farfara, 5 parts Dendrobium nobile, 5 parts Platycodon grandiflorus, and 5 parts roasted Terminalia chebula.

[0026] The preparation process is the same as in Example 1.

[0027] Example 3 This embodiment also provides a traditional Chinese medicine preparation with wind-preventing and cough-relieving effects, the components of which are as follows: 1. Preparation of raw materials: Accurately weigh the following ingredients by weight: 15 parts Saposhnikovia divaricata, 15 parts Schizonepeta tenuifolia, 8 parts Mentha haplocalyx, 10 parts Oroxylum indicum, 8 parts Glycyrrhiza uralensis, 10 parts Dictamnus dasycarpus, 10 parts Prunus mume, 10 parts honey-processed Tussilago farfara, 8 parts Dendrobium nobile, 8 parts Platycodon grandiflorus, and 8 parts roasted Terminalia chebula.

[0028] The preparation process is the same as in Example 1.

[0029] Example 4 This embodiment also provides a traditional Chinese medicine preparation with wind-preventing and cough-relieving effects, the components of which are as follows: 1. Preparation of raw materials: Accurately weigh the following ingredients by weight: 20 parts Saposhnikovia divaricata, 20 parts Schizonepeta tenuifolia, 11 parts Mentha haplocalyx, 14 parts Oroxylum indicum, 11 parts Glycyrrhiza uralensis, 15 parts Dictamnus dasycarpus, 14 parts Prunus mume, 14 parts honey-processed Tussilago farfara, 11 parts Dendrobium nobile, 11 parts Platycodon grandiflorus, and 11 parts Terminalia chebula.

[0030] The preparation process is the same as in Example 1.

[0031] Experimental Example 1 The traditional Chinese medicine preparations prepared in Examples 1 and 4 were used respectively. A total of 24 patients with cough were treated and statistically analyzed using the traditional Chinese medicine preparation of Example 1, and 18 patients with cough were treated and statistically analyzed using the traditional Chinese medicine preparation of Example 4. The cough was caused by external wind-cold, and the patients showed symptoms such as heavy cough, thin and clear white phlegm, nasal congestion and runny nose.

[0032] Treatment method: Take 10g each time, three times a day; follow up and collect statistics on the treatment effect, including the number of people who see results within 2 days, see results within 5 days, are cured within 1 week, and are cured within 2 weeks. See results means that the clinical symptoms are reduced or disappear; cure means that the clinical symptoms disappear; the statistical results are shown in Table 1.

[0033] Table 1. Statistics on the effectiveness of follow-up treatment As shown in Table 1 and the case follow-up, the traditional Chinese medicine preparations prepared in the embodiments of the present invention have a good therapeutic effect on cough with symptoms of exogenous wind-cold. Among them, the traditional Chinese medicine preparation prepared with the component ratio in Example 1 has a faster onset of action. Most patients can achieve good cough and asthma relief within 2 days. At the same time, the cure rate is higher within one week. After one week, only a very small number of cases have occasional choking cough 1-2 times, and no cough at other times.

[0034] Although the present invention has been described in detail through the preferred embodiments above, it should be understood that the above description should not be considered as a limitation of the present invention. Various modifications and substitutions to the present invention will be apparent to those skilled in the art after reading the above description. Therefore, the scope of protection of the present invention should be defined by the appended claims.

Claims

1. A traditional Chinese medicine formula with antitussive and cough-relieving effects, characterized in that, This traditional Chinese medicine formula includes Saposhnikovia divaricata, Schizonepeta tenuifolia, Mentha haplocalyx, Oroxylum indicum, Glycyrrhiza uralensis, Dictamnus dasycarpus root bark, Prunus mume, honey-processed Tussilago farfara, Dendrobium nobile, Platycodon grandiflorus, and Terminalia chebula.

2. The traditional Chinese medicine formula according to claim 1, characterized in that, It is made from the following ingredients in parts by weight: Saposhnikovia divaricata 1-20 parts, Schizonepeta tenuifolia 1-20 parts, Mentha haplocalyx 1-11 parts, Oroxylum indicum 1-14 parts, Glycyrrhiza uralensis 1-11 parts, Dictamnus dasycarpus 1-15 parts, Prunus mume 1-14 parts, Coltsfoot flower (honey-processed) 1-14 parts, Tianzhuzi 1-11 parts, Platycodon grandiflorus 1-11 parts, and Terminalia chebula (roasted) 1-11 parts.

3. The traditional Chinese medicine formula according to claim 1, characterized in that, The weight parts of each ingredient are as follows: Saposhnikovia divaricata 10-20 parts, Schizonepeta tenuifolia 10-20 parts, Mentha haplocalyx 5-11 parts, Oroxylum indicum 7-14 parts, Glycyrrhiza uralensis 5-11 parts, Dictamnus dasycarpus 7-15 parts, Prunus mume 7-14 parts, Coltsfoot flower (honey-processed) 7-14 parts, Tianzhuzi 5-11 parts, Platycodon grandiflorus 5-11 parts, and Terminalia chebula (baked) 5-11 parts.

4. The traditional Chinese medicine formula according to claim 1, characterized in that, The weight parts of each ingredient are as follows: Saposhnikovia divaricata 15 parts, Schizonepeta tenuifolia 15 parts, Mentha haplocalyx 8 parts, Oroxylum indicum 10 parts, Glycyrrhiza uralensis 8 parts, Dictamnus dasycarpus 10 parts, Prunus mume 10 parts, honey-processed Tussilago farfara 10 parts, Dendrobium nobile 8 parts, Platycodon grandiflorus 8 parts, and Terminalia chebula 8 parts.

5. The application of the traditional Chinese medicine formula as described in any one of claims 1-4 in the preparation of traditional Chinese medicine preparations with the effects of preventing wind and relieving cough.

6. A traditional Chinese medicine preparation having the effect of preventing wind and relieving cough, prepared from the traditional Chinese medicine formula according to any one of claims 1-4.

7. A method for preparing a traditional Chinese medicine preparation as described in claim 6, characterized in that, Includes the following steps: S1: Soak Saposhnikovia divaricata, Schizonepeta tenuifolia, and Mentha haplocalyx in warm water, then distill to extract the volatile oil for later use; S2: Boil the dregs after extracting the volatile oil with the remaining eight medicinal materials in water, filter, combine the filtrates, and concentrate into a thick paste; S3: Add dextrin to the thick paste, granulate, and dry; S4: Spray in the prepared volatile oil, mix well, and store in a sealed container to obtain granules.

8. The preparation method according to claim 7, characterized in that, In step S1, the soaking temperature is 40℃-50℃ and the soaking time is 1-2 hours.

9. The preparation method according to claim 7, characterized in that, In step S2, the simmering is performed twice, for one hour each time.

10. The preparation method according to claim 7, characterized in that, In steps S1 and S2, the amount of water added is 10 times the weight of the raw materials.

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