Anti-wrinkle repairing composition based on synergism of polypeptide and plant extract and application of anti-wrinkle repairing composition

Abstract

The invention discloses an anti-wrinkle repairing composition based on synergism of polypeptide and plant extract and application of the anti-wrinkle repairing composition, and belongs to the technical field of cosmetics. The composition is prepared from the following six active ingredients in percentage by weight: decapeptide-4, inositol choline glycerophosphate, betaine, medicinal rheum officinale root extract, Chinese herbaceous peony root extract and glycoprotein. And auxiliary materials acceptable in cosmetics. All the active ingredients have a synergistic effect in a specific concentration range to form a functional module for resisting aging, repairing, conditioning oil pox and strengthening a barrier. Preferably, the composition also comprises deionized water, glycerol, butanediol, a specific thickening agent, an emulsifier, a pH regulator, a preservative and other auxiliary materials. The composition disclosed by the invention can be used for integrally and efficiently improving various oil acne skin-sensitive problems such as wrinkles, coarse pores, excessive grease secretion, skin redness and fragile barriers, has the characteristics of synergistic interaction, mildness and safety, and can be applied to preparation of skin care products such as essence and face cream.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to an anti-wrinkle repair composition based on the synergistic effect of peptides and plant extracts and its application. Background Technology

[0002] With increasing life pressures, the number of people with "oily, acne-prone, and sensitive skin"—characterized by oily skin, acne-proneness, and a fragile skin barrier—is growing. This type of skin problem is complex and presents three main challenges in skincare:

[0003] 1. It is difficult to balance anti-aging and skin tolerance: Although classic anti-wrinkle ingredients such as retinoic acid and high-concentration fruit acid are effective in promoting collagen regeneration and accelerating keratin metabolism, their strong irritation can easily cause or aggravate redness, stinging and peeling of sensitive skin, making it difficult for people with oily, acne-prone and sensitive skin to carry out anti-aging care safely and effectively.

[0004] Second, there is a contradiction between acne treatment and barrier protection: commonly used acne-removing ingredients such as salicylic acid can effectively unclog pores and inhibit acne bacteria, but may damage the sebum film and cause dehydration of the stratum corneum, further weakening the barrier function; while using only soothing and repairing products cannot fundamentally regulate sebum secretion and microbial imbalance, which only treats the symptoms and not the root cause.

[0005] Third, a vicious cycle of impaired barrier function: Oily, acne-prone, and sensitive skin inherently has an incomplete barrier structure, weak moisturizing and water-locking ability, and is easily irritated by external stimuli. A damaged barrier, in turn, exacerbates inflammatory responses and abnormal sebum secretion, creating a vicious cycle of "oil-acne-sensitivity" that reinforces each other.

[0006] Most commercially available skincare products are designed for a single skin problem, focusing on anti-wrinkle, acne treatment, or soothing, making it difficult to meet the integrated skincare needs of oily, acne-prone, and sensitive skin that require "highly effective anti-aging, gentle acne treatment, and simultaneous repair." Simply combining different active ingredients often results in reduced effectiveness or even increased burden on the skin due to poor formula compatibility and conflicting mechanisms of action.

[0007] Therefore, there is an urgent need in this field to develop an active ingredient composition that can systematically address multiple problems of oily, acne-prone, and sensitive skin, has a clear synergistic effect among its components, and is both gentle and highly effective. Summary of the Invention

[0008] The purpose of this invention is to overcome the shortcomings and deficiencies of the existing technology and to provide an anti-wrinkle repair composition and its application based on the synergistic effect of peptides and plant extracts.

[0009] Therefore, the technical solution provided in this application is as follows: The first aspect of the present invention provides an anti-wrinkle repair composition based on the synergistic effect of polypeptides and plant extracts.

[0010] To achieve the above objectives, the present invention provides the following technical solution: the composition comprises the following components by weight percentage:

[0011] c) The active ingredient, comprising: decapeptide-4: 0.0001% to 0.1%; glycerophosphoinositol choline salt: 0.1% to 5%; betaine: 0.5% to 8%; rhubarb root extract: 0.1% to 3%; peony root extract: 0.1% to 3%; glycoprotein: 0.01% to 2%;

[0012] d) Cosmetic-acceptable excipients, in excess.

[0013] The anti-wrinkle repair composition based on the synergistic effect of peptides and plant extracts according to claim 1 is characterized in that: the content of each active ingredient, based on the total weight percentage of the composition, is as follows: decapeptide-4: 0.001%; ​​glycerophosphoinositol choline salt: 1%-2%; betaine: 3%-5%; rhubarb root extract: 0.5%-0.8%; peony root extract: 1%-1.5%; glycoprotein: 0.1%-0.2%.

[0014] As a preferred embodiment of the present invention, the content of each active ingredient, based on the total weight percentage of the composition, is as follows: decapeptide-4: 0.001%; ​​glycerophosphoinositol choline salt: 1%-2%; betaine: 3%-5%; rhubarb root extract: 0.5%-0.8%; peony root extract: 1%-1.5%; glycoprotein: 0.1%-0.2%.

[0015] As a preferred embodiment of the present invention, the cosmetically acceptable excipients include one or more of solvents, humectants, thickeners, emulsifiers, pH adjusters, and preservatives.

[0016] In a preferred embodiment of the present invention, the solvent is deionized water; the total amount of the humectant is 3%-9% of the total weight of the composition; the total amount of the thickener is 0.1%-0.5% of the total weight of the composition; the total amount of the emulsifier is 1%-3% of the total weight of the composition; the amount of the pH adjuster is 0.05%-0.3% of the total weight of the composition, used to adjust the pH value of the composition to 5.0-6.0; and the total amount of the preservative is 0.5%-1.0% of the total weight of the composition.

[0017] As a preferred embodiment of the present invention, the dosage form of the composition is an essence, lotion, cream, ampoule, or mask.

[0018] As a preferred embodiment of the present invention, the composition is an essence, comprising, by weight percentage: decapeptide-4: 0.001%; ​​glycerophosphate inositol choline salt: 1.0%; betaine: 3.0%; rhubarb root extract: 0.5%; peony root extract: 1.0%; glycoprotein: 0.1%; deionized water: to 100%; glycerol: 5.0%; butylene glycol: 4.0%; acrylate / C10-30 alkanol acrylate crosspolymer: 0.15%; bis-PEG-18 methyl ether dimethylsiloxane: 1.5%; caprylic / capric triglyceride: 2.0%; cetearyl isonononate: 1.5% (this is a pre-commercially prepared raw material, known as "self-emulsifying wax"); triethanolamine: 0.05%-0.1%, used to adjust the pH to 5.5-6.0; phenoxyethanol / ethylhexylglycerin: 0.8%.

[0019] As a preferred embodiment of the present invention, the composition is a face cream, comprising, by weight percentage: decapeptide-4: 0.001%; ​​glycerophosphoinositol choline salt: 2.0%; betaine: 5.0%; rhubarb root extract: 0.8%; peony root extract: 1.5%; glycoprotein: 0.2%; deionized water: to 100%; glycerin: 8.0%; xanthan gum: 0.1%; cetearyl alcohol / cetearyl alcohol polyether-20: 2.5%; caprylic / capric triglyceride: 8.0%; shea butter: 3.0%; polydimethylsiloxane: 1.5%; 1,2-hexanediol / caprylyl glycol: 1.0%.

[0020] The second aspect of the present invention provides the application of the first aspect of the present invention in the preparation of skin care products for improving oily, acne-prone, and sensitive skin problems.

[0021] In summary, the beneficial effects of this invention are as follows:

[0022] 1. The six active ingredients in this composition are not simply mixed, but rather achieve a systematic synergistic effect through a well-defined modular design: In terms of anti-aging, decapeptide-4 acts as a signal peptide, mimicking the body's repair signals to activate fibroblasts and accelerate the synthesis of collagen, elastin, and other youth-rejuvenating matrix components. Meanwhile, glycerophosphate inositol choline salt, as a cellular energy precursor, directly provides ample energy for this high-intensity biosynthetic process. Together, they form a highly efficient anti-aging core engine of "instruction + energy," ensuring maximum collagen regeneration efficiency. In terms of conditioning oily, acne-prone, and sensitive skin, rhubarb root extract inhibits 5α-reductase activity. By reducing sebum secretion and inhibiting Propionibacterium acnes at its source, peony root extract exerts broad-spectrum anti-inflammatory and immunomodulatory effects to alleviate redness and swelling. Betaine, through its excellent osmotic pressure regulation and powerful hydration, maintains moisture balance at the cellular level and buffers external stimuli. These three components form a comprehensive system of "purification + soothing + stabilization." Regarding barrier repair, glycoproteins directly participate in intercellular adhesion, promoting keratinocyte proliferation and differentiation to accelerate the structural repair of the skin's physical barrier. This synergistic effect, combined with the deep moisturizing properties of betaine and the soothing environment created by peony root extract, strengthens the skin barrier function. Ultimately, these three functional modules support each other, achieving synergistic effects beyond single ingredients in three dimensions: highly effective anti-wrinkle, gentle acne treatment, and a strong skin barrier. This provides a technological foundation for a holistic solution to the complex problems of oily, acne-prone, and sensitive skin.

[0023] 2. The concentration range of the active ingredients in this invention is crucial for achieving optimal synergistic effects and ensuring safety. Decapeptide-4, as a highly active signal peptide, exhibits insufficient signal strength below 0.0001%, making it difficult to effectively initiate collagen synthesis instructions. Conversely, concentrations above 0.1% not only diminish in effectiveness but may also induce cell receptor desensitization or irritation. Glycerylphosphoinositol choline salt, as a cellular energy substrate, fails to provide sufficient energy for fibroblasts to respond to peptide instructions below 0.1%, while concentrations above 5% lead to skin saturation, resulting in waste and increased stickiness. Betaine fully utilizes its powerful hydration and osmotic pressure buffering capacity within the range of 0.5% to 8%. Concentrations that are too low result in ineffective moisturizing and stabilizing effects, while concentrations that are too high may affect the skin feel of the formula. For plant extract components, medicinal rhubarb root extract, within the range of 0.1% to 3%, effectively regulates oil production and inhibits acne bacteria, while avoiding the dryness or irritation risks associated with high concentrations of anthraquinone components. Peony root extract effectively exerts its anti-inflammatory and soothing effects within the same concentration range, working synergistically with rhubarb extract. Insufficient concentration weakens the soothing effect, while excessive concentration may affect the product's color or stability due to the complexity of its plant components. Glycoproteins are key to barrier repair; an addition of 0.01% to 2% can effectively promote cell adhesion and differentiation. Too low a concentration limits the barrier repair effect, while too high a concentration can lead to a sticky feel on the skin due to its large molecular size.

[0024] 3. The compositions of this invention need to be formulated with necessary cosmetic excipients to form a stable and usable dosage form. The solvent (mainly deionized water) serves as the base, added up to 100%. Moisturizers (such as glycerin, butylene glycol, etc., totaling 3%-9%) provide basic moisturizing. Thickeners (such as xanthan gum, carbomer, etc., totaling 0.1%-0.5%) are used to adjust product viscosity and improve skin feel. When preparing emulsions or creams, 1%-3% emulsifier needs to be added to stabilize the oil-water phases. The formulation needs to be adjusted to the skin's suitable slightly acidic range (pH 5.0-6.0) using pH adjusters (such as triethanolamine, citric acid, approximately 0.05%-0.3%). Furthermore, 0.5%-1.0% preservatives (such as phenoxyethanol, etc.) must be added to ensure the product's microbial safety during its shelf life. The types and amounts of these excipients are fundamental to ensuring product stability, safety, and a good user experience. Too little may lead to product instability or poor skin feel, while too much may introduce unnecessary irritation. Detailed Implementation

[0025] The technical solution of the present invention will be described in detail below through specific embodiments. These embodiments are for illustrative purposes only and are not intended to limit the scope of protection of the present invention.

[0026] To make the objectives, technical solutions, and advantages of the present invention clearer, the implementation methods of the present invention will be described in detail below with reference to specific embodiments. It should be noted that the described embodiments are intended to facilitate understanding of the present invention and are not intended to limit the scope of the present invention.

[0027] The compositions of the present invention can be prepared by conventional cosmetic preparation methods in the art (such as heating, stirring, emulsification, homogenization).

[0028] Example 1: Anti-wrinkle repair serum

[0029] This embodiment provides a serum with a light texture that focuses on high-efficiency penetration and deep anti-wrinkle effects.

[0030] Formula composition:

[0031]

[0032]

[0033] Preparation process:

[0034] Pretreatment: Carbomer in phase A is uniformly dispersed in deionized water and allowed to stand until it swells completely.

[0035] Aqueous phase preparation: Add the remaining raw materials of phase A to water, heat to 75-80℃ with stirring, and make them completely dissolved and homogeneous.

[0036] Oil phase preparation: Mix all raw materials of phase B, heat to 75-80℃ with stirring, and let it melt and clarify completely.

[0037] Emulsification: Under homogenous stirring, slowly add the oil phase (phase B) to the aqueous phase (phase A), maintain homogenization at 75-80℃ for 3-5 minutes to form a uniform emulsion.

[0038] Cooling and neutralization: Stop homogenization, start anchor stirring, and cool to approximately 40-45°C. Slowly add phase D (triethanolamine solution) and adjust the pH of the system to 5.5-6.0.

[0039] Adding active ingredients: When the temperature drops below 40℃, add each active ingredient in phase C in sequence with slow stirring, ensuring that each ingredient is evenly dispersed before adding the next one.

[0040] Final adjustment: Add phase D (preservative) and stir well.

[0041] Discharge: Continue stirring and cooling to room temperature. After passing inspection, discharge and fill.

[0042] Example 2: Anti-wrinkle repair face cream

[0043] This embodiment provides a face cream with a rich texture that combines moisturizing and anti-aging effects, and has a longer-lasting repair effect.

[0044] Formula composition:

[0045]

[0046]

[0047] Preparation process

[0048] Aqueous phase preparation: Mix the raw materials of phase A, heat to 80-85℃ with stirring, maintain for 20 minutes for sterilization, and ensure that xanthan gum is completely dissolved.

[0049] Oil phase preparation: Mix all raw materials of phase B, heat to 80-85℃ with stirring, and let it melt and clarify completely.

[0050] Emulsification: Under homogenous stirring, slowly add the aqueous phase (phase A) to the oil phase (phase B), maintain homogenization at 80-85℃ for 5-8 minutes to form a uniform and delicate paste.

[0051] Cooling: Stop homogenizing, switch to anchor stirring, and begin cooling. The stirring speed should be sufficient to ensure uniform cooling of the entire pot and prevent air entrapment.

[0052] Adding active ingredients: When the temperature drops below 40℃, add the various active ingredients in phase C slowly and sequentially while stirring at a slow speed to ensure uniform dispersion.

[0053] Final adjustment: Add phase D (preservative) and stir well.

[0054] Discharge: Continue stirring and cooling to 30-35℃. After passing inspection, discharge and fill.

[0055] To verify the significant effects of the composition of the present invention, we conducted a comprehensive evaluation through in vitro experiments and human clinical trials.

[0056] Example 3: Preparation of serum (for efficacy evaluation): The experimental sample was prepared using the same formula and process as in Example 1.

[0057] Experiment 1: Evaluation of fibroblast activity and collagen production in vitro:

[0058] Objective: To verify the promoting effect of the composition on skin fibroblast activity and collagen synthesis capacity, as well as the synergistic effect between components.

[0059] Methods: Normal human dermal fibroblasts (HDF) were cultured.

[0060] Cell viability assay (MTT method): Cells were co-cultured with different samples (negative control, 1% of the present invention's extract, 1% decapeptide-4, 1% glycerophosphate inositol choline salt) for 24 h before detection.

[0061] Type I collagen content detection (ELISA method): After co-culturing cells with different samples (negative control, 1% of the present invention's essence, 1% decapeptide-4, 1% decapeptide-4 + 1% glycerophosphate inositol choline salt) for 48 h, the type I collagen content in the cell supernatant was detected.

[0062] result:

[0063] Cell activity: Compared with the negative control (100%), the cell activity of the 1% essence of this invention group was increased to 128% ± 5%, which was significantly higher than that of the single component group.

[0064] Type I collagen synthesis:

[0065]

[0066] Conclusion: The composition of the present invention exhibits a highly significant synergistic effect in promoting cell activity and collagen production, with effects far exceeding those of single components or simple combinations thereof.

[0067] Experiment 2: Evaluation of in vitro antibacterial and anti-inflammatory efficacy

[0068] Objective: To verify the inhibitory effect of the composition on Propionibacterium acnes and its anti-inflammatory and soothing ability, and to elucidate the synergistic effect among the components.

[0069] method:

[0070] Antibacterial activity: The minimum inhibitory concentration (MIC) of the sample against Propionibacterium acnes was determined using the microbroth dilution method.

[0071] Anti-inflammatory properties: In a lipopolysaccharide (LPS)-induced mouse mononuclear macrophage (RAW264.7) inflammation model, after sample intervention, the content of tumor necrosis factor-α (TNF-α) in the cell supernatant was detected by ELISA.

[0072] result:

[0073] Antibacterial activity (Minimum inhibitory concentration (MIC) against Propionibacterium acnes)

[0074] The table below shows the MIC values ​​of different sample groups, expressed as volume percentage (v / v). The lower the value, the stronger the antibacterial ability.

[0075]

[0076] in conclusion:

[0077] The composition of this invention exhibits the strongest antibacterial effect (MIC = 0.78%), which is four times more potent than that of rhubarb root extract alone (MIC = 3.125%). Data shows that although peony root extract has no direct antibacterial activity, it produces a synergistic effect when combined with rhubarb extract (MIC decreases to 1.56%), while the complete composition shows the best effect, demonstrating the value of multi-component synergistic action.

[0078] Anti-inflammatory activity (inhibition rate of LPS-induced TNF-α release)

[0079] At a sample concentration of 1%, the inhibition rate of TNF-α in each experimental group was measured, and the results are expressed as mean ± standard deviation (n = 3).

[0080]

[0081] in conclusion:

[0082] At a concentration of 1%, the complete composition of this invention exhibits an inhibition rate of up to 75.3% against TNF-α, significantly superior to the same concentration of single peony root extract (45.1%) or other binary combinations. This fully demonstrates that the components in the composition (especially the broad-spectrum anti-inflammatory effect of peony root, the auxiliary anti-inflammatory effect of rhubarb, and the soothing effect of betaine) produce a powerful synergistic effect at the anti-inflammatory level, rather than a simple additive effect.

[0083] It should be noted that the negative control mentioned in this invention is Example 1, which does not contain any active ingredient.

[0084] Experiment 3: Evaluation of Human Efficacy

[0085] Objective: To evaluate the overall improvement effect of the composition of the present invention on volunteers with oily, acne-prone, and sensitive skin through clinical trials.

[0086] Methods: Thirty-five volunteers aged 25-45 with mild to moderate oily, acne-prone, and sensitive skin were recruited. They used the serum prepared in Example 3 twice daily, morning and evening, for 8 consecutive weeks. Evaluation indicators were assessed before use (week 0), at week 4, and after week 8.

[0087] Instrument evaluation: The VISIA-CR facial image analysis system was used to analyze wrinkle depth, number of pores, area of ​​brown spots (pigmentation), and area of ​​red areas (inflammation / redness). The Cornemeter CM825 was used to measure stratum corneum moisture content, and the Sebumeter was used to measure sebum secretion rate.

[0088] Expert assessment: A professional dermatologist will score the degree of enlarged pores, number of acne, facial redness, skin texture and radiance (0-9 points, the higher the score, the better).

[0089] Self-assessment: Volunteers fill out questionnaires to rate the product's improvement effects and their satisfaction.

[0090] Results: Some key data are shown in the table below (values ​​are mean ± standard deviation, n = 35).

[0091]

[0092] Note: * indicates a significant difference compared to week 0 (p<0.05), ** indicates a highly significant difference (p<0.01).

[0093] Conclusion: Human trial data show that after 8 weeks of use of the serum of this invention, volunteers experienced statistically significant improvements in multiple dimensions, including anti-wrinkle (significantly reduced wrinkle depth), oil control and acne treatment (reduced sebum secretion and improved inflammation in red areas), barrier repair and moisturizing (significantly increased stratum corneum moisture content), and overall skin quality (significantly improved expert scores). This demonstrates that the composition can effectively improve multiple complex problems of oily, acne-prone, and sensitive skin in an integrated manner, and has good safety with no reports of serious adverse reactions.

[0094] Overall Conclusion

[0095] This invention successfully developed a compound composition based on six active ingredients: decapeptide-4, glycerophosphate inositol choline salt, betaine, rhubarb root extract, peony root extract, and glycoprotein. Based on the above embodiments and comprehensive efficacy evaluation data, the following core conclusions can be drawn: A clear synergistic mechanism enables precise multi-target intervention: This invention is not a simple accumulation of ingredients, but rather the construction of a hierarchical and interconnected synergistic network. Specifically, "decapeptide-4 (commander)" and "glycerophosphate inositol choline salt (power bank)" constitute the core engine of anti-aging, effectively solving the key problem of "having commands and energy"; "rhubarb root extract (acne-clearing vanguard)," "peony root extract (soothing master)," and "betaine (moisturizing buffer)" form a conditioning module for oily, acne-prone, and sensitive skin, achieving a balance of "purification, soothing, and stabilization"; and "glycoprotein (cell adhesive)" synergistically strengthens the skin barrier repair together with other ingredients. These three modules support each other, systematically covering the entire chain from anti-wrinkle and regeneration, oil control and acne treatment to soothing and repair, demonstrating a synergistic effect that significantly surpasses that of single ingredients or conventional combinations.

[0096] Conclusive efficacy data validates the superior effectiveness of this integrated solution: In vitro experiments have demonstrated that this composition exhibits powerful and synergistic biological activity in promoting collagen production (increased to 173.4%), inhibiting Propionibacterium acnes (MIC value increased by 4 times compared to rhubarb extract alone), and anti-inflammatory effects (TNF-α inhibition rate reached 75.3%). An 8-week human clinical trial further showed that this composition simultaneously and significantly improved wrinkle depth (-23.9%), pore count (-19.5%), sebum secretion (-25.5%), inflammatory redness (-43.2%), and skin hydration (+39.9%), strongly demonstrating its powerful efficacy and good safety profile in addressing multiple issues of oily, acne-prone, and sensitive skin.

[0097] With strong technological innovation and significant industrial application value, this invention addresses a current market gap by proposing a multi-effect solution combining anti-aging, acne treatment, and repair, specifically designed for oily, acne-prone, and sensitive skin. The provided serum, cream, and other specific formulations have mature and stable processes, facilitating industrial production. This technology offers a novel, efficient, and gentle approach to solving this complex skincare challenge, possessing significant market application prospects and commercial value.

[0098] In summary, this invention, through innovative ingredient combinations and a clear synergistic mechanism, successfully provides an active composition and cosmetic with significant efficacy, high safety, and good stability, bringing a breakthrough technological advancement to the comprehensive care of oily, acne-prone, and sensitive skin.

[0099] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely preferred examples and are not intended to limit the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as defined by the appended claims and their equivalents.

Claims

1. An anti-wrinkle care composition based on the synergy of a polypeptide and a plant extract, characterized in that, The composition comprises the following components by total weight percentage: a) active ingredients consisting of: Decapeptide-4: 0.0001% to 0.1%; glycerophosphoinositol choline salt: 0.1% to 5%; Betaine: 0.5% to 8%; medicinal rhizoma rhei extract: 0.1% to 3%; radix paeoniae extract: 0.1% to 3%; Glycoprotein: 0.01% to 2%; b) cosmetically acceptable adjuvants, the balance.

2. Anti-wrinkle care composition based on the synergy of polypeptides with plant extracts according to Claim 1, characterized in that: The content of each active ingredient is: Decapeptide-4: 0.001%; glycerophosphoinositol choline salt: 1%-2%; betaine: 3%-5%; medicinal rhizoma rhei extract: 0.5%-0.8%; radix paeoniae extract: 1%-1.5%; glycoprotein: 0.1%-0.2% by total weight percentage of the composition. The cosmetically acceptable adjuvant includes one or more of a solvent, a humectant, a thickening agent, an emulsifier, a pH regulator and a preservative.

3. The anti-wrinkle care composition based on the synergy of polypeptides and plant extracts according to claim 1, characterized in that: The solvent is deionized water; the total amount of the humectant is 3%-9% of the total weight of the composition; the total amount of the thickening agent is 0.1%-0.5% of the total weight of the composition; the total amount of the emulsifier is 1%-3% of the total weight of the composition; the amount of the pH regulator is 0.05%-0.3% of the total weight of the composition, which is used to adjust the pH value of the composition to 5.0-6.0; the total amount of the preservative is 0.5%-1.0% of the total weight of the composition.

4. Anti-wrinkle care composition based on the synergy of polypeptides with plant extracts according to Claim 3, characterized in that: The dosage form of the composition is serum, emulsion, cream, ampoule or mask.

5. Anti-wrinkle care composition based on the synergy of polypeptides with plant extracts according to any one of claims 1 to 4, characterized in that: The composition is serum, which comprises the following components by weight percentage: Decapeptide-4: 0.001%; glycerophosphoinositol choline salt: 1.0%; betaine: 3.0%; medicinal rhizoma rhei extract: 0.5%; radix paeoniae extract: 1.0%; glycoprotein: 0.1%; deionized water: added to 100%; glycerol: 5.0%; butylene glycol: 4.0%; acrylates / C10-30 alkyl acrylate crosspolymer: 0.15%; bis-PEG-18 methyl ether dimethicone: 1.5%; caprylic / capric triglyceride: 2.0%; cetearyl isononanoate: 1.5%; triethanolamine: appropriate amount for adjusting the pH to 5.5-6.0; phenoxyethanol / ethylhexylglycerin: 0.8%.

6. The anti-wrinkle care composition based on the synergy of polypeptides and plant extracts according to claim 5, characterized in that: The composition is cream, which comprises the following components by weight percentage: Decapeptide-4: 0.001%; glycerophosphoinositol choline salt: 2.0%; betaine: 5.0%; medicinal rhizoma rhei extract: 0.8%; radix paeoniae extract: 1.5%; glycoprotein: 0.2%; deionized water: added to 100%; glycerol: 8.0%; xanthan gum: 0.1%; ceteareth-20: 2.5%; caprylic / capric triglyceride: 8.0%; shea butter: 3.0%; dimethicone: 1.5%; 1,2-hexanediol / caprylyl glycol: 1.0%.

7. The anti-wrinkle care composition based on the synergy of polypeptides and plant extracts according to claim 5, characterized in that: ​ 8. Use of the anti-wrinkle care composition based on the synergy of polypeptides and plant extracts according to any one of claims 1 to 7 for the manufacture of a skin care product for improving the problems of oily, acne-prone, sensitive skin.

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