Succinic acid-nicotinamide eutectic crystal as well as preparation method and application thereof

By preparing succinic acid-nicotinamide cocrystals and utilizing weak interactions such as hydrogen bonds to construct a stable crystal structure, the problems of nicotinamide stability and short retention time of succinic acid were solved, achieving oil control and whitening effects in cosmetics and skin care products.

CN121471135AActive Publication Date: 2026-02-06PROYA COSMETICS CO LTD
2 Cites 0 Cited by

Patent Information

Application Number
CN202610024372.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-09
Publication Date
2026-02-06
Estimated Expiration
2046-01-09

AI Technical Summary

Technical Problem

In existing technologies, niacinamide has poor stability, succinic acid has a short retention time on the skin surface, making it difficult to exert long-lasting soothing or oil-controlling effects, and there is a lack of research on the formation of specific crystal form supramolecular cocrystals by succinic acid and niacinamide.

Method used

The preparation method involves mixing succinic acid and nicotinamide in a suitable solvent at a specific molar ratio, followed by ultrasonic stirring and gradient cooling crystallization to form a triclinic succinic acid-nicotinamide eutectic. A stable crystal structure is constructed by utilizing weak interactions such as hydrogen bonding.

Benefits of technology

It improves the stability and residue effect of succinic acid-niacinamide cocrystal on the skin surface, enhances its bioavailability in personal care products, cosmetics and skin care products, and significantly improves oil control and whitening effects.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention discloses a succinic acid-nicotinamide eutectic crystal and a preparation method and application thereof.The molecular formula of the succinic acid-nicotinamide eutectic crystal is C16H18N4O6, the structural formula of the succinic acid-nicotinamide eutectic crystal is shown in the specification, the preparation method comprises the following steps that S1, succinic acid and a solvent are weighed according to the proportion and mixed, and a succinic acid solution is obtained; s2, weighing nicotinamide, adding the nicotinamide into the succinic acid solution, and performing ultrasonic treatment and stirring until the nicotinamide is completely dissolved to obtain a mixed solution; s3, cooling and crystallizing the mixed solution to obtain separated crystals; and S4, filtering the separated crystal by using a Buchner funnel, and drying the solid obtained by filtering in a vacuum drying oven to obtain the succinic acid-nicotinamide eutectic crystal. The invention has the advantages of convenient preparation and relatively low cost, and can be applied to the preparation of personal cleaning products, cosmetics and skin care products with whitening and oil control effects.
Need to check novelty before this filing date? Find Prior Art