Green and stale intestine moistening soup for preventing and treating constipation after anorectal disease operation as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a green and stale intestine moistening soup for preventing and treating constipation after anorectal disease operation and a preparation method and application thereof. The green tangerine peel and pericarpium citri reticulatae intestine moistening soup is prepared from the following raw material medicines in parts by weight: 12 to 15 parts of green tangerine peel, 15 to 17 parts of pericarpium citri reticulatae, 12 to 15 parts of radix scrophulariae, 15 to 25 parts of radix rehmanniae, 20 to 30 parts of radix angelicae sinensis, 12 to 15 parts of rhizoma pinelliae, 15 to 17 parts of cortex magnoliae officinalis, 12 to 20 parts of fructus aurantii immaturus and 15 to 17 parts of fructus aurantii. When a patient suffering from anorectal disease postoperative constipation takes the prepared Qingchen intestine moistening soup, the overall curative effect on the anorectal disease postoperative constipation and the improvement condition of postoperative clinical symptoms are obviously improved, which shows that the prepared Qingchen intestine moistening soup has an exact curative effect on the anorectal disease postoperative constipation, and has the effects of softening excrement, moistening intestines, promoting digestion and the like. The labor-consuming degree of defecation is reduced, and the abdominal distension is relieved.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine composition technology, specifically relating to a Qingchen Runchang Decoction for preventing and treating postoperative constipation in anorectal diseases, its preparation method, and its application. Background Technology

[0002] Constipation is a common complication after surgery for hemorrhoids, fistulas, and fissures in anorectal patients. It mainly manifests as difficulty in defecation, reduced frequency of bowel movements, small and hard stools, anal distension and pain, and a feeling of incomplete evacuation. It can also cause abdominal distension, abdominal pain, and loss of appetite; in severe cases, fecal impaction may occur. Hard, dry stools can easily scratch the surgical wound as they pass through the anus, leading to edema, tearing, pain, and bleeding, increasing the risk of infection, and potentially delaying wound healing. Therefore, postoperative constipation significantly increases patient suffering and directly affects the effectiveness of surgery, even potentially leading to surgical failure. Postoperative constipation can also trigger secondary massive bleeding, collapse, and other critical complications, and induce or aggravate cardiovascular and cerebrovascular diseases such as coronary heart disease and cerebral infarction. Current techniques often use Qi Rong Run Chang oral liquid to treat postoperative constipation, but the efficacy is unsatisfactory. Therefore, providing a new strategy for preventing and treating postoperative constipation in anorectal patients has become a top priority in postoperative treatment in anorectal surgery. Summary of the Invention

[0003] The purpose of this invention is to provide a Qingchen Runchang Decoction for preventing and treating postoperative constipation in anorectal diseases. The Qingchen Runchang Decoction of this invention not only effectively relieves the clinical symptoms of postoperative constipation, but also improves the overall efficacy of postoperative constipation in anorectal diseases.

[0004] The technical solution adopted in this invention is: This invention provides a Qingchen Runchang Decoction for preventing and treating postoperative constipation in anorectal diseases, wherein the Qingchen Runchang Decoction is made from the following raw materials in parts by weight: Green tangerine peel 12-15 parts, dried tangerine peel 15-17 parts, scrophularia root 12-15 parts, rehmannia root 15-25 parts, angelica root 20-30 parts, pinellia tuber 12-15 parts, magnolia bark 15-17 parts, immature bitter orange 12-20 parts, and immature bitter orange peel 15-17 parts.

[0005] The Qingchen Runchang Decoction is a well-formulated prescription, modified from Zengye Decoction. Green tangerine peel and dried tangerine peel are the principal herbs, working together to soothe the liver, regulate qi, strengthen the spleen, and harmonize intestinal qi. Rehmannia root and Scrophularia root are the assistant herbs, nourishing yin, increasing fluids, and moistening the intestines. Angelica root nourishes and invigorates blood, moistens the intestines, and promotes bowel movements, improving postoperative yin and blood deficiency. Aurantium root regulates qi, relieves chest congestion, and promotes gastrointestinal motility. Pinellia root descends rebellious qi and eliminates turbidity. Aurantium fruit and Magnolia bark are added to regulate qi and relieve stagnation. Clinical application can be adjusted according to the symptoms. If the patient has difficulty straining during defecation, add Astragalus root and Atractylodes macrocephala to invigorate qi and strengthen the spleen, promoting gastrointestinal motility. If qi stagnation and blood stasis cause pain, add Corydalis rhizome and Curcuma root to regulate qi, invigorate blood, and relieve pain. If the patient experiences anal distension and discomfort, add Bupleurum root and Cimicifuga rhizome to raise yang qi.

[0006] Preferably, the Qingchen Runchang Decoction is made from the following raw materials in parts by weight: 15 parts green tangerine peel, 15 parts dried tangerine peel, 15 parts scrophularia root, 15 parts rehmannia root, 30 parts angelica root, 15 parts pinellia tuber, 15 parts magnolia bark, 20 parts immature bitter orange, and 15 parts immature bitter orange peel.

[0007] The second aspect of this invention also provides a method for preparing the Qingchen Runchang Decoction, comprising the following steps: Weigh the raw materials according to the stated weight proportions, mix them, add water, and simmer for 20 to 30 minutes after the water boils to obtain Qingchen Runchang Decoction.

[0008] Preferably, the decocting conditions are: decocting for 25 minutes after the water boils.

[0009] The third aspect of the present invention provides the application of the Qingchen Runchang Decoction, specifically: the Qingchen Runchang Decoction is freeze-dried at -40℃ to -50℃ to obtain Qingchen Runchang freeze-dried powder; the Qingchen Runchang freeze-dried powder is used to prepare a preparation for preventing and treating postoperative constipation in anorectal diseases.

[0010] Preferably, the acceptable dosage form of the preparation includes any one of tablets, capsules, granules, pills, powders, and oral liquids.

[0011] Preferably, the formulation further includes pharmaceutically acceptable excipients.

[0012] Preferably, the pharmaceutically acceptable excipients include at least one of diluents, flavoring agents, disintegrants, lubricants, antacids, and nutritional fortifiers.

[0013] Preferably, the diluent includes any one of lactose, mannitol, microcrystalline cellulose, and corn starch.

[0014] Preferably, the flavoring agent includes any one of steviol glycosides, aspartame, and sucrose.

[0015] Preferably, the disintegrant includes any one of starch, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose.

[0016] Preferably, the lubricant comprises any one of magnesium stearate, talc, and polyethylene glycol.

[0017] Preferably, the antacid agent includes either calcium carbonate or aluminum hydroxide.

[0018] Preferably, the nutritional fortifier includes any one of vitamin A, vitamin C, and vitamin D.

[0019] Compared with the prior art, the beneficial effects of the present invention are: This invention provides a Qingchen Runchang Decoction for preventing and treating postoperative constipation in patients with anorectal diseases. The decoction is made from the following raw materials in parts by weight: 12-15 parts of green tangerine peel, 15-17 parts of dried tangerine peel, 12-15 parts of scrophularia root, 15-25 parts of rehmannia root, 20-30 parts of angelica root, 12-15 parts of pinellia tuber, 15-17 parts of magnolia bark, 12-20 parts of immature bitter orange, and 15-17 parts of immature bitter orange peel. Patients with postoperative constipation after anorectal diseases were given the Qingchen Runchang Decoction prepared according to this invention. The time of the first bowel movement after surgery, the shape of stool, the degree of difficulty in defecation, and the abdominal distension score at different postoperative time points were observed. It was found that compared with Qirong Runchang Oral Liquid, the Qingchen Runchang Decoction of this invention significantly improved the overall efficacy and the improvement of postoperative clinical symptoms in treating postoperative constipation after anorectal diseases. This indicates that the Qingchen Runchang Decoction prepared according to this invention is effective in treating postoperative constipation after anorectal diseases, softening stool, reducing the difficulty of defecation, and relieving abdominal distension. Attached Figure Description

[0020] Figure 1 A statistical chart showing the classification of fecal shapes for each group.

[0021] Figure 2 The chart shows the statistical results of the treatment effects for each group. Detailed Implementation

[0022] The present invention will be further illustrated below with specific embodiments, but these embodiments do not limit the scope of the invention. Modifications or substitutions to the details and form of the technical solutions of the present invention may be made without departing from the spirit and scope of the invention, but all such modifications or substitutions fall within the protection scope of the present invention.

[0023] The inventive concept of this invention is as follows: The main factors leading to constipation after anorectal surgery include: ① Postoperative wound pain can cause patients to suppress the urge to defecate or lose the urge altogether. Prolonged retention of stool in the intestinal lumen leads to excessive water absorption and hardened stool, resulting in painful defecation and a cycle of severe constipation. ② Anxiety and fear caused by hospitalization and surgery can inhibit the control of peripheral autonomic nerves over the large intestine, and preoperative bowel preparation can alter bowel habits, all contributing to constipation. ③ Low-residue diets after surgery result in insufficient fiber and water content in the intestines. ④ Postoperative bed rest reduces activity and slows intestinal peristalsis. ⑤ The effects of anesthetics on the gastrointestinal tract weaken intestinal peristalsis and inhibit intestinal fluid secretion.

[0024] In clinical practice, constipation following anorectal surgery is often treated symptomatically in Western medicine, such as with stimulant laxatives. However, long-term use can lead to complications such as laxative-induced colon and electrolyte imbalances. Temporary enemas and enemas may provide temporary relief, but they can cause pain and bleeding at the surgical site, significantly increasing patient suffering. Traditional Chinese medicine, on the other hand, utilizes a holistic approach, treating postoperative constipation through syndrome differentiation and treatment, offering diverse treatment methods and demonstrating unique advantages.

[0025] Postoperative constipation following anorectal surgery falls under the category of "constipation" in traditional Chinese medicine, primarily affecting the large intestine, but it is closely related to functional abnormalities of the lungs, liver, spleen, and kidneys. The pathogenesis mainly manifests as "qi stagnation and intestinal dryness." Surgical removal of diseased tissue from the anus damages the qi and blood vessels, leading to qi imbalance in the intestines, dysfunction of large intestine conduction, and disordered meridian transmission, resulting in the retention of waste. Surgery also depletes blood and fluids, leading to insufficient blood and fluids, intestinal dryness, and the formation of dry, hard stools. This invention, based on the specific condition of postoperative patients, uses Qingchen Runchang Decoction to treat postoperative constipation following anorectal surgery, achieving good results.

[0026] The Qingchen Runchang Decoction of this invention is a well-formulated prescription, modified from Zengye Decoction. Green tangerine peel and dried tangerine peel are the principal herbs, working together to soothe the liver, regulate qi, strengthen the spleen, and harmonize intestinal qi. Rehmannia root and Scrophularia root are the assistant herbs, nourishing yin, increasing fluids, and moistening the intestines. Angelica root nourishes blood, invigorates blood circulation, moistens the intestines, and promotes bowel movements, improving postoperative yin and blood deficiency. Aurantium root regulates qi, relieves chest congestion, and promotes gastrointestinal motility. Pinellia rhizome descends rebellious qi and eliminates turbidity. Aurantium fruit and Magnolia bark are added to regulate qi and relieve stagnation. Clinical application can be adjusted according to the symptoms. If the patient has difficulty straining during defecation, Astragalus root and Atractylodes rhizome can be added to invigorate qi and strengthen the spleen, promoting gastrointestinal motility. If qi stagnation and blood stasis cause pain, Corydalis rhizome and Curcuma rhizome can be added to invigorate qi, activate blood circulation, and relieve pain. If the patient experiences anal distension and discomfort, Bupleurum root and Cimicifuga rhizome can be added to raise yang qi.

[0027] This invention utilizes Qingchen Runchang Decoction to treat postoperative constipation in anorectal patients, shortening the time to the first bowel movement. Compared with Qirong Runchang Oral Liquid, Qingchen Runchang Decoction can significantly reduce abdominal distension, improve defecation difficulty, and increase bowel movement frequency in postoperative anorectal patients; moreover, clinical observation shows that it does not cause adverse reactions such as diarrhea or electrolyte imbalance. Therefore, Qingchen Runchang Decoction can effectively alleviate the clinical symptoms of postoperative constipation while improving the overall efficacy of treatment for postoperative anorectal constipation.

[0028] In summary, the Qingchen Runchang Decoction of this invention is formulated to address the pathogenesis of postoperative constipation in patients with anorectal diseases, including damage to the anal meridians, liver qi stagnation, intestinal qi obstruction, impaired transmission, retention of waste, deficiency of body fluids and blood, and insufficient nourishment of the large intestine, leading to constipation. It has the effects of regulating qi and clearing the bowels, nourishing yin and blood, and moistening the intestines to relieve constipation. It treats both the symptoms and the root cause, helping postoperative patients promote bowel movements, soften stools, and reduce abdominal distension. Clinical trials have verified that the Qingchen Runchang Decoction can effectively prevent and treat postoperative constipation in patients with anorectal diseases.

[0029] To enable those skilled in the art to better understand and implement the technical solutions of this invention, the invention will be further described below with reference to specific embodiments. Unless otherwise specified, all reagents used in this invention are commercially available, and all methods used are conventional techniques in the art.

[0030] In the following examples, 1g represents one part by weight.

[0031] Example 1 The preparation method of Qingchen Runchang Decoction for preventing and treating postoperative constipation in anorectal diseases is as follows: Weigh out 15g of green tangerine peel, 15g of dried tangerine peel, 15g of scrophularia root, 15g of rehmannia root, 30g of angelica root, 15g of pinellia tuber, 15g of magnolia bark, 12g of immature bitter orange, and 15g of immature bitter orange peel; mix them together and add 1000mL of water. Bring to a boil over high heat in a clay pot, then simmer over low heat for 20 minutes until the liquid reaches 200mL. This is the Qingchen Runchang Decoction.

[0032] Example 2 The preparation method of Qingchen Runchang Decoction for preventing and treating postoperative constipation in anorectal diseases is as follows: Weigh out 12g of green tangerine peel, 15g of dried tangerine peel, 12g of scrophularia root, 20g of rehmannia root, 20g of angelica root, 12g of pinellia tuber, 15g of magnolia bark, 18g of immature bitter orange, and 16g of immature bitter orange peel; mix them together and add 1000mL of water. Bring to a boil over high heat in a clay pot, then simmer over low heat for 20 minutes until the liquid reaches 200mL. This is the Qingchen Runchang Decoction.

[0033] Example 3 The preparation method of Qingchen Runchang Decoction for preventing and treating postoperative constipation in anorectal diseases is as follows: Weigh out 12g of green tangerine peel, 17g of dried tangerine peel, 12g of scrophularia root, 25g of rehmannia root, 20g of angelica root, 12g of pinellia tuber, 17g of magnolia bark, 20g of immature bitter orange, and 17g of immature bitter orange peel; mix them together and add 1000mL of water. Bring to a boil over high heat in a clay pot, then simmer over low heat for 30 minutes until the liquid reaches 200mL. This is the Qingchen Runchang Decoction.

[0034] It was verified that the Qingchen Runchang Decoction prepared in Examples 1 to 3 had no significant difference in efficacy in preventing and treating postoperative constipation in anorectal diseases. Therefore, only the results of Example 1 will be presented in the following sections.

[0035] Example 4 The application of Qingchen Runchang Decoction for preventing and treating postoperative constipation in anorectal diseases is as follows: This invention conducted a randomized controlled study on 80 patients who underwent anorectal surgery and were hospitalized in the Department of Anorectal Surgery of Xi'an Traditional Chinese Medicine Hospital from January 2023 to December 2023, using Qingchen Runchang Decoction to prevent and treat postoperative constipation in patients with anorectal diseases.

[0036] 1. Materials and Methods.

[0037] 1.1 General Information.

[0038] We selected 160 postoperative anorectal disease patients who were hospitalized in the Department of Anorectal Surgery of Xi'an Traditional Chinese Medicine Hospital from January 2023 to December 2023. 152 of them were valid cases and were randomly divided into a treatment group and a control group. All patients signed informed consent forms.

[0039] The treatment group consisted of 80 patients: 44 males and 36 females, aged 21 to 75 years, with an average age of 50 years; among them, 47 had mixed hemorrhoids, 23 had anal fistulas, and 10 had anal fissures.

[0040] The control group consisted of 72 cases: 42 males and 30 females, aged 23 to 68 years, with an average age of 42 years; 40 cases of mixed hemorrhoids, 17 cases of anal fistula, and 15 cases of anal fissure.

[0041] Statistical analysis showed no significant differences between the two groups in terms of gender, age, and disease type. P The value was >0.05, indicating comparability. During the trial, 8 patients in the control group withdrew from the study: 1 patient had postoperative bleeding, 2 patients withdrew voluntarily, 3 patients had difficulty defecating and received enema treatment, 1 patient discontinued treatment due to diarrhea, and 1 patient was transferred to another hospital due to postoperative cerebrovascular disease.

[0042] 1.2 Inclusion, exclusion, and removal criteria.

[0043] Inclusion criteria: Inpatients who meet the diagnostic criteria for common anorectal diseases such as hemorrhoids, fistulas and fissures and have undergone surgical treatment in our department; male and female patients aged 18 to 60 years; patients who are willing to participate and have signed an informed consent form.

[0044] Exclusion criteria: Patients with organic constipation confirmed by colonoscopy, defecography and slow transit colon test; patients with contraindications to surgery such as liver and kidney dysfunction, cardiovascular and cerebrovascular diseases, hematopoietic system abnormalities; and women who are pregnant or lactating.

[0045] Exclusion criteria for cases: failure to cooperate with medication or failure to strictly follow medication instructions; allergic reactions or postoperative complications such as massive bleeding during treatment that prevent continued trial; withdrawal of the patient on their own or inability to continue the trial without justifiable cause.

[0046] 1.3 Treatment.

[0047] General treatment: After fasting for 6 hours after surgery, patients can eat semi-liquid foods such as millet porridge. Normal diet can begin on the first day after surgery, with plenty of fresh vegetables and fruits. Psychological counseling should also be provided, and patients should be advised not to be afraid of defecation.

[0048] Treatment group: Starting from the first day after surgery, patients were given Qingchen Runchang Decoction prepared in Example 1 orally, 100mL / time, once in the morning and once in the evening.

[0049] Control group: Starting from the first day after surgery, patients took Qi Rong Run Chang Oral Solution orally, one vial each time, twice a day, morning and evening. Qi Rong Run Chang Oral Solution was purchased from Beijing Beiwei Pharmaceutical Co., Ltd., batch number Z20000034, 20ml / vial.

[0050] Treatment course: One week constitutes one course of treatment. Both groups took two courses of treatment consecutively before stopping the medication. The efficacy was then observed and evaluated.

[0051] 1.4 Statistical methods.

[0052] All data were statistically analyzed using SPSS 17.0 software. Chi-square test was used for count data, and rank-sum test was used for ordinal data. Quantitative data were expressed as mean ± mean difference and analyzed using a two-sample t-test. P A value <0.05 is considered statistically significant.

[0053] 2. Indicators for observing therapeutic effects.

[0054] 2.1. Time of first bowel movement after surgery.

[0055] Record the date and time of the patient's first bowel movement after surgery, and calculate the interval between the first bowel movement and the surgery, in hours, which is the onset time of the medication.

[0056] 2.2 Clinical symptom score.

[0057] Record the patient's stool shape, defecation difficulty score, and abdominal distension score during four time periods: day 1-3, day 4-6, day 8-10, and day 11-13 postoperatively. If there are multiple defecations within the same time period, record the score of the first defecation within that time period.

[0058] (1) Stool shape: According to the Bristol stool shape chart, type 1 is a separate hard ball, type 2 is a lump, type 3 is a dry and cracked sausage shape, type 4 is a soft sausage shape, type 5 is a soft lump, type 6 is pasty, and type 7 is watery. Types 4 and 5 are normal stool shapes, types 1, 2 and 3 indicate constipation, and types 6 and 7 indicate diarrhea.

[0059] (2) Degree of difficulty in defecation: 0 points for defecation without effort, 1 point for defecation with effort, 2 points for defecation with effort, and 3 points for defecation with manual assistance.

[0060] (3) Abdominal distension: 0 points for no abdominal distension, 1 point for mild abdominal distension, 2 points for more obvious abdominal distension, and 3 points for abdominal distension that significantly affects normal life and work.

[0061] 2.3. Efficacy evaluation criteria.

[0062] Recovery: Bowel movements occur at least once a day, and Bristol stools are of type 4 or 5 shape with no difficulty in defecation and bloating disappears.

[0063] Effective: Bowel movement once a day, with a type 2 or 3 stool, and bowel movement is slightly difficult; or once every 2 to 3 days, with a type 4 or 5 stool, and occasional abdominal bloating.

[0064] Effective: Bowel movements occur once every 2-3 days, with the stool being of type 2 or 3 shape. Bowel movements are difficult and there is occasional abdominal bloating.

[0065] Ineffective: Bowel movements occur less than once a week, stool shape is type 1 to 3, bowel movements are difficult, and there is obvious abdominal distension.

[0066] 3. Results.

[0067] 3.1. Time of first bowel movement after surgery.

[0068] The time to first defecation was 38.12±9.07h in the treatment group and 40.38±8.97h in the control group. The time to first defecation was shorter in the treatment group than in the control group, but the difference between the two groups was not statistically significant. P >0.05).

[0069] 3.2 Clinical symptom score.

[0070] (1) The shape of the stool and the degree of difficulty in defecation.

[0071] The treatment group showed significantly better scores in stool shape and defecation difficulty during the postoperative periods of days 1-3 and 4-6 compared to the control group. P <0.05); there were no significant differences between the two groups on postoperative days 8-10 and 11-13. Results are shown in Tables 1-3 and... Figure 1 .

[0072] Table 1. Stool Shape Classification / Number of Cases Table 2 Percentage of each fecal shape subtype Table 3. Scoring results for difficulty in defecation (points) (2) Abdominal distension.

[0073] The improvement in abdominal distension in the treatment group at all postoperative time points was significantly better than that in the control group, and the difference was statistically significant. P <0.05). Compared with the control group, the effective rate of the treatment group was significantly higher than that of the control group ( P <0.05). The results indicate that Qingchen compound is significantly effective in treating postoperative constipation in patients with anorectal diseases. See Table 4.

[0074] Table 4 Abdominal distension score results (points) 3.3. Therapeutic effect.

[0075] Compared with the control group, the effective rate of the treatment group was significantly higher than that of the control group. P＜0.05 The results are shown in Table 5 and Figure 2 The results show that the Qingchen Runchang Decoction prepared in this invention has a significant therapeutic effect on postoperative constipation in patients with anorectal diseases.

[0076] Table 5 Comparison of clinical efficacy between the two groups (cases) Note: Tables 1-5 compare the treatment group with the control group. △ P <0.05.

[0077] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0078] The embodiments described above are merely examples of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements all fall within the scope of protection of the present invention.

Claims

1. A Qingchen Runchang Decoction for preventing and treating postoperative constipation of anorectal diseases, characterized in that, The Qingchen Runchang Decoction is made of raw medicinal materials in the following weight parts: Pericarpium Citri Reticulatae Viride 12-15 parts, Pericarpium Citri Reticulatae 15-17 parts, Scrophularia 12-15 parts, Rehmannia 15-25 parts, Angelica 20-30 parts, Rhizoma Pinelliae 12-15 parts, Magnolia officinalis 15-17 parts, Aurantii Fructus Immaturus 12-20 parts, and Aurantii Fructus 15-17 parts.

2. The green ginseng soup of claim 1, wherein the green ginseng is selected from the group consisting of ginseng, red ginseng, white ginseng, and a mixture thereof. The Qingchen Runchang Decoction is made of raw medicinal materials in the following weight parts: Pericarpium Citri Reticulatae Viride 15 parts, Pericarpium Citri Reticulatae 15 parts, Scrophularia 15 parts, Rehmannia 15 parts, Angelica 30 parts, Rhizoma Pinelliae 15 parts, Magnolia officinalis 15 parts, Aurantii Fructus Immaturus 20 parts, and Aurantii Fructus 15 parts.

3. The preparation method of the Qingchen Runchang Tang according to claim 1, characterized in that, The steps are as follows: The raw medicinal materials are weighed according to the weight parts, mixed, and then water is added. After the water is boiled, the decoction is boiled for 20-30 minutes to obtain the Qingchen Runchang Decoction.

4. The production method according to claim 3, wherein The decoction condition is that the decoction is boiled for 25 minutes after the water is boiled.

5. The use of the Qingchen Runchang Tang according to claim 1, characterized in that, The application refers to any one of the following: (1) the Qingchen Runchang Decoction is freeze-dried to prepare Qingchen Runchang freeze-dried powder; (2) the Qingchen Runchang Decoction is used to prepare a preparation for preventing and treating postoperative constipation of anorectal diseases.

6. Use according to claim 5, wherein The acceptable dosage form of the preparation includes any one of tablets, capsules, granules, pills, powders, and oral liquids.

7. The use according to claim 5, wherein the compound is ###00003### or a pharmaceutically acceptable salt thereof. The preparation further includes a pharmaceutically acceptable excipient.

8. Use according to claim 7, wherein the compound is ###0002### The pharmaceutically acceptable excipient includes at least one of diluents, flavoring agents, disintegrants, lubricants, antacids, and nutritional fortifiers. The pharmaceutically acceptable excipient includes at least one of diluents, flavoring agents, disintegrants, lubricants, antacids, and nutritional fortifiers.

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