Preparation method of anti-diabetic traditional Chinese medicine composition

Abstract

The invention relates to the technical field of medicines, in particular to a preparation method of an anti-diabetic traditional Chinese medicine composition. Through long-term research, the raw medicinal materials are processed by adopting different processing methods, and the anti-diabetic traditional Chinese medicine composition disclosed by the invention has a good anti-diabetic effect through the steps of decocting, concentrating and the like in combination with a specific ratio. Specifically, in the aspect of processing, corresponding processing methods are adopted according to the characteristics of different medicinal materials, so that the medicine effect of the medicinal materials in the aspect of resisting diabetes mellitus is exerted to the greatest extent; in the aspect of the formula, the anti-diabetes traditional Chinese medicine composition is endowed with the function of improving diabetes mellitus through the synergistic effect of the raw materials under the specific dosage, and a new thought is provided for research and development of diabetes mellitus medicines. The result of the embodiment shows that the anti-diabetic traditional Chinese medicine composition provided by the invention has a remarkable treatment effect on diabetes, the average fasting blood-glucose is reduced by more than 23% after the composition is taken for 60 days, and the anti-diabetic traditional Chinese medicine composition is small in side effect, short in treatment cycle and remarkable in social benefit.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medicine, in particular to a preparation method of an anti-diabetic traditional Chinese medicine composition. BACKGROUND

[0002] As a common metabolic disease, diabetes has different stages of illness, and the traditional treatment methods mainly include oral hypoglycemic drugs and insulin therapy, which can effectively control blood glucose and reduce the risk of complications. However, the above methods still have a series of problems, such as hypoglycemic events, liver and kidney burden, weight gain, and drug dependence and other side effects, and some patients face the challenges of high treatment cost, long cycle, and large individual response difference.

[0003] In view of the above problems, medical researchers have developed a variety of new diabetes treatment strategies, such as GLP-1 receptor agonists, SGLT2 inhibitors, and insulin pumps and continuous glucose monitoring systems, which can improve blood glucose control while reducing some side effects. However, how to obtain a stable blood glucose-lowering effect, less side effects and short treatment cycle of diabetes treatment method is still a key problem to be solved in the field. SUMMARY

[0004] Therefore, the present application provides a preparation method of an anti-diabetic traditional Chinese medicine composition, and the anti-diabetic traditional Chinese medicine composition prepared by the preparation method has good prevention and treatment effect of diabetes, and the drug side effects are not obvious, and the treatment cycle is short.

[0005] The present application provides a preparation method of an anti-diabetic traditional Chinese medicine composition, comprising the following steps: (1) Raw material processing: steaming asparagus to obtain processed asparagus; Honey-roasting ophiopogon to obtain processed ophiopogon; Vinegar processing of coptis followed by drying to obtain processed coptis; Slicing of scrophulariaceae to obtain scrophulariaceae slices, and then spraying yellow rice wine, followed by dampening and drying, to obtain processed scrophulariaceae; Mixing of lotus leaf and refined sugar to obtain dampening, followed by frying and drying, to obtain processed lotus leaf; Boiling thick-wood and ginger decoction together until the ginger juice is absorbed, and then drying, to obtain processed thick-wood; (2) Raw material weighing: weighing 28-32 parts of processed asparagus, 28-32 parts of processed ophiopogon, 42-48 parts of processed coptis, 43-47 parts of processed scrophulariaceae, 58-62 parts of radix trichosanthis, 57-62 parts of anemarrhena, 8-10 parts of radix ginseng, 8-10 parts of monascus, 12-18 parts of dried ginger, and 28-32 parts of processed thick-wood, according to the mass fraction; (3) the prepared asparagus, prepared ophiopogon, prepared coptis, prepared scutellaria, prepared lotus leaf, prepared magnolia officinalis are soaked in water, then are sequentially decocted and concentrated to obtain the anti-diabetic traditional Chinese medicine composition.

[0006] Preferably, the steaming pressure is normal pressure, and the time is 35-40 minutes.

[0007] Preferably, the honey baking comprises the following steps: mixing the prepared ophiopogon and the diluted refined honey, and frying until the prepared ophiopogon is yellow and not sticky.

[0008] Preferably, the mass ratio of the prepared ophiopogon and the refined honey is 100:10-15.

[0009] Preferably, the vinegar processing comprises the following steps: mixing the prepared coptis and rice vinegar, and then frying until the surface is dry and not sticky.

[0010] Preferably, the mass ratio of the prepared coptis and rice vinegar is 100:10-14.

[0011] Preferably, the lotus leaf is lotus leaf silk; the mass ratio of the lotus leaf and the refined honey is 100:15-18.

[0012] Preferably, the raw materials are weighed according to the mass fraction as follows: prepared asparagus 30 parts, prepared ophiopogon 30 parts, prepared coptis 45 parts, prepared scutellaria 45 parts, prepared lotus leaf 45 parts, radix trichosanthis 60 parts, anemarrhena 60 parts, American ginseng 9 parts, monascus 9 parts, dried ginger 15 parts, and prepared magnolia officinalis 30 parts.

[0013] Preferably, the total mass of the prepared asparagus, prepared ophiopogon, prepared coptis, prepared scutellaria, prepared lotus leaf, prepared magnolia officinalis, radix trichosanthis, anemarrhena, American ginseng, monascus, and dried ginger is 1:8-13 times the mass of water; the concentration multiple is 2-4 times.

[0014] Preferably, the decoction comprises the following steps: boiling the soaked medicinal materials and water, and then keeping boiling; the keeping boiling time is 30-45 minutes.

[0015] This invention, through long-term research, explores and obtains a preparation method for the above-mentioned anti-diabetic traditional Chinese medicine composition. By processing the raw materials using different methods and combining specific dosages, through steps such as decoction and concentration, the anti-diabetic traditional Chinese medicine composition of this invention exhibits good preventive and therapeutic effects on diabetes. Specifically, from a processing perspective, this invention targets different medicinal materials for specific processing to maximize their therapeutic effect on diabetes; from a formulation perspective, this invention, through the combined effect of specific amounts of raw materials (including processed or directly used), endows the anti-diabetic traditional Chinese medicine composition of this invention with the efficacy of preventing and treating diabetes, providing a new avenue for the development of drugs for treating diabetes. The results of the examples show that the anti-diabetic traditional Chinese medicine composition of this invention has good preventive and therapeutic effects on diabetes; after 60 days of medication, the average fasting blood glucose level decreased by more than 23%, with minimal side effects, a short treatment cycle, and significant social benefits. Detailed Implementation

[0016] This invention provides a method for preparing an anti-diabetic traditional Chinese medicine composition, comprising the following steps: (1) Raw material processing: Steaming the asparagus to obtain processed asparagus; Processed Ophiopogon japonicus is obtained by honey-frying Ophiopogon japonicus. Coptis chinensis is vinegar-processed and then dried to obtain processed Coptis chinensis. Scutellaria baicalensis is sliced ​​to obtain Scutellaria baicalensis slices. The Scutellaria baicalensis slices are then sprayed with rice wine, moistened and dried to obtain processed Scutellaria baicalensis. After mixing lotus leaves and refined honey and soaking them in water, they are stir-fried and dried in sequence to obtain processed lotus leaves. Magnolia officinalis is boiled with ginger until the ginger juice is absorbed, and then dried to obtain processed Magnolia officinalis. (2) Weighing raw materials: Weigh 28-32 parts of processed Asparagus root, 28-32 parts of processed Ophiopogon japonicus root, 42-48 parts of processed Coptis chinensis root, 43-47 parts of processed Scutellaria baicalensis root, 43-47 parts of processed Nelumbo nucifera leaf, 58-62 parts of Trichosanthes kirilowii root, 57-62 parts of Anemarrhena asphodeloides rhizome, 8-10 parts of American ginseng root, 12-18 parts of dried ginger root, and 28-32 parts of processed Magnolia officinalis root according to the mass fraction; (3) The processed Asparagus, processed Ophiopogon japonicus, processed Coptis chinensis, processed Scutellaria baicalensis, processed Nelumbo nucifera leaf, processed Magnolia officinalis, Trichosanthes kirilowii, Anemarrhena asphodeloides, Panax quinquefolius and dried ginger are soaked in water and then decocted and concentrated in sequence to obtain a traditional Chinese medicine composition for antidiabetic diseases.

[0017] This invention involves steaming asparagus to obtain processed asparagus. In this invention, the steaming pressure is preferably atmospheric pressure, the temperature is preferably steam temperature, and the steaming time is preferably 35-40 minutes, more preferably 32 minutes.

[0018] In this invention, the process of steaming preferably includes peeling the steamed asparagus.

[0019] This invention involves processing Ophiopogon japonicus with honey to obtain processed Ophiopogon japonicus. In this invention, the honey processing preferably includes the following steps: mixing Ophiopogon japonicus with diluted refined honey and then stir-frying (referred to as the first stir-frying) until the surface of the Ophiopogon japonicus turns yellow and is no longer sticky.

[0020] In this invention, the dilution is preferably done with boiling water (100 degrees Celsius); the dilution is preferably done so that the honey can adhere to the surface of the Ophiopogon japonicus.

[0021] In this invention, the mass ratio of Ophiopogon japonicus to refined honey is preferably 100:10~15, more preferably 100:13.

[0022] In this invention, the first stir-frying is preferably done over a low heat; the temperature of the first stir-frying is preferably 90-100 degrees Celsius, and the heat preservation time is preferably 35-40 minutes.

[0023] This invention involves processing Coptis chinensis with vinegar and then drying it to obtain processed Coptis chinensis. In this invention, the vinegar processing preferably includes the following steps: mixing Coptis chinensis with rice vinegar and allowing it to soak (referred to as the first soaking) and then stir-frying (referred to as the second stir-frying) until the surface is dry and not sticky.

[0024] In this invention, the mass ratio of Coptis chinensis to rice vinegar is preferably 100:10~14, more preferably 100:11~12.

[0025] In this invention, the first soaking time is preferably based on the absorption of rice vinegar by Coptis chinensis; the first soaking time is preferably 2 to 4 hours, more preferably 3 hours.

[0026] In this invention, the second stir-frying is preferably done over a low heat; the temperature of the second stir-frying is preferably 80-100 degrees Celsius, more preferably 90 degrees Celsius, and the heat preservation time is preferably 30-50 minutes, more preferably 40 minutes.

[0027] This invention involves slicing Scutellaria baicalensis to obtain Scutellaria baicalensis slices, then sequentially spraying the slices with rice wine, followed by a second moistening process (referred to as the second moistening) and air-drying to obtain processed Scutellaria baicalensis. In this invention, the thickness of the slices is preferably 1-2 mm, more preferably 1.5 mm.

[0028] In this invention, the mass ratio of Scutellaria baicalensis slices to rice wine is preferably 100:8~11, more preferably 100:9.

[0029] In this invention, the temperature of the second humidification is preferably 8 to 35 degrees Celsius, more preferably 25 to 35 degrees Celsius, and the time of the second humidification is preferably 5 to 7 hours, more preferably 6 hours.

[0030] This invention involves mixing lotus leaves and refined honey, then soaking them (referred to as the third soaking), followed by stir-frying (referred to as the third stir-frying) and drying to obtain processed lotus leaves. In this invention, the lotus leaves are preferably lotus leaf shreds; the lotus leaves are preferably washed before use; the mass ratio of lotus leaves to refined honey is preferably 100:15~18, more preferably 100:16.

[0031] In this invention, the preferred method for mixing lotus leaves and refined honey is to spray refined honey onto lotus leaf shreds and then stir and mix them.

[0032] In this invention, the temperature of the third humidification is preferably 15-25 degrees Celsius, more preferably 22 degrees Celsius; the time of the third humidification is preferably 30-50 minutes, more preferably 45 minutes.

[0033] In this invention, the temperature for the third stir-frying is preferably 116-118 degrees Celsius, more preferably 117 degrees Celsius, and the holding time is preferably until the lotus leaf surface turns deep yellow and a honey-caramel aroma is detected. After stir-frying, remove from the pan promptly and spread out to cool.

[0034] This invention involves simmering Magnolia officinalis and ginger together until the ginger juice is absorbed, then drying (referred to as the first drying step) to obtain processed Magnolia officinalis. In this invention, the Magnolia officinalis is preferably pre-treated before use; the pre-treatment preferably includes the following steps: taking one or more of the bark, root bark, and branch bark of Magnolia officinalis, scraping off the rough outer bark, and washing it clean.

[0035] In this invention, the step of decocting and cooking together preferably includes soaking, shredding and drying the Magnolia officinalis in sequence (referred to as the second drying); the soaking preferably includes the following steps: soaking the Magnolia officinalis in water; the soaking time is preferably 2 to 5 hours, more preferably 4 hours.

[0036] In this invention, the second drying method is preferably sun drying.

[0037] In this invention, the mass ratio of Magnolia officinalis to ginger is preferably 100:9~12, more preferably 100:10.

[0038] In this invention, the temperature of the first drying step is preferably 50 to 70 degrees Celsius.

[0039] After obtaining processed Asparagus root, processed Ophiopogon root, processed Coptis root, processed Scutellaria root, processed lotus leaf, and processed Magnolia bark, this invention weighs out the following parts by weight: 28-32 parts processed Asparagus root, 28-32 parts processed Ophiopogon root, 42-48 parts processed Coptis root, 43-47 parts processed Scutellaria root, 43-47 parts processed lotus leaf, 58-62 parts Trichosanthes root, 57-62 parts Anemarrhena rhizome, 8-10 parts American ginseng, 8-10 parts red yeast rice, 12-18 parts dried ginger, and 28-32 parts processed Magnolia bark. In this invention, the preferred part by weight of the processed Asparagus root is 29-31 parts, more preferably 30 parts.

[0040] In this invention, the processed Ophiopogon japonicus is preferably 29 to 31 parts by weight, and more preferably 30 parts by weight.

[0041] In this invention, the mass fraction of the processed Coptis chinensis is preferably 44 to 46 parts, more preferably 45 parts.

[0042] In this invention, the processed Scutellaria baicalensis is preferably 44 to 46 parts by weight, more preferably 45 parts by weight.

[0043] In this invention, the mass fraction of the processed lotus leaf is preferably 44 to 46 parts, more preferably 45 parts.

[0044] In this invention, the mass fraction of the pollen is preferably 59 to 61 parts, more preferably 60 parts.

[0045] In this invention, the mass fraction of Anemarrhena asphodeloides is preferably 58 to 61 parts, more preferably 60 parts.

[0046] In this invention, the Anemarrhena asphodeloides is preferably anemarrhena asphodeloides slices; the thickness of the anemarrhena asphodeloides slices is preferably 5-8 cm, more preferably 6 cm.

[0047] In this invention, the preferred mass fraction of the American ginseng is 9 parts.

[0048] In this invention, the American ginseng is preferably American ginseng slices; the thickness of the American ginseng slices is preferably 0.2~0.3 mm.

[0049] In this invention, the preferred mass fraction of the red yeast rice is 9 parts.

[0050] In this invention, the preferred mass fraction of the dried ginger is 13 to 17 parts, more preferably 15 parts.

[0051] In this invention, the dried ginger is preferably dried ginger slices; the thickness of the dried ginger slices is preferably 2-4 mm, more preferably 3 mm.

[0052] In this invention, the mass fraction of the processed Magnolia officinalis is preferably 29 to 31 parts, more preferably 30 parts.

[0053] After weighing the raw materials, the present invention soaks the processed Asparagus, processed Ophiopogon japonicus, processed Coptis chinensis, processed Scutellaria baicalensis, processed Nelumbo nucifera leaf, processed Magnolia officinalis, Trichosanthes kirilowii, Anemarrhena asphodeloides, American ginseng, red yeast rice, and dried ginger in water, and then decocts and concentrates them in sequence to obtain an anti-diabetic traditional Chinese medicine composition.

[0054] In this invention, the ratio of the total mass of the processed Asparagus cochinchinensis, processed Ophiopogon japonicus, processed Coptis chinensis, processed Scutellaria baicalensis, processed Nelumbo nucifera leaf, processed Magnolia officinalis, Trichosanthes kirilowii, Anemarrhena asphodeloides, American ginseng, red yeast rice, and dried ginger to the mass of water is preferably 1:8 to 13, more preferably 1:10.

[0055] In this invention, the soaking time is preferably 30 to 50 minutes, more preferably 35 to 40 minutes; the soaking temperature is preferably room temperature (15 to 35 degrees Celsius).

[0056] In this invention, the decoction preferably includes the following steps: boiling the soaked medicinal materials and water and then keeping it boiling; the boiling time is preferably 30 to 45 minutes, more preferably 35 to 40 minutes.

[0057] In this invention, the concentration factor (the volume ratio of the drug solution before and after concentration) is preferably 2 to 4 times.

[0058] This invention, through long-term research, explores and obtains a preparation method for the above-mentioned anti-diabetic traditional Chinese medicine composition. By processing the raw materials using different methods and combining specific dosages, through steps such as decoction and concentration, the anti-diabetic traditional Chinese medicine composition of this invention exhibits good efficacy. Specifically, from a processing perspective, this invention targets different medicinal materials for specific processing to maximize their effectiveness in preventing and treating diabetes; from a formulation perspective, this invention, through the combined effect of specific amounts of raw materials (including processed or directly used), endows the anti-diabetic traditional Chinese medicine composition of this invention with the efficacy of treating diabetes, providing a new avenue for the development of diabetes drugs. The results of the examples show that the anti-diabetic traditional Chinese medicine composition of this invention has good therapeutic effects on diabetes, with an average fasting blood glucose reduction of more than 23% after 60 days of medication, demonstrating significant social benefits.

[0059] To further illustrate the present invention, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments thereof. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0060] Example 1 This embodiment prepares a traditional Chinese medicine composition for treating diabetes. Steps (1) to (6) do not have a specific time order requirement. The specific steps are as follows: (1) Steam the asparagus at normal pressure for 35 minutes, and peel the steamed asparagus to obtain processed asparagus.

[0061] (2) Dilute the honey with 100°C water so that the honey can adhere to the surface of Ophiopogon japonicus; mix 100g of Ophiopogon japonicus with the diluted honey (of which the mass of honey is 10g), and then stir-fry over a low flame at 90°C for 40 minutes until the surface of Ophiopogon japonicus turns yellow and is not sticky, thus obtaining processed Ophiopogon japonicus.

[0062] (3) Mix 100g of Coptis chinensis and 14g of rice vinegar and let it soak for 4 hours until the rice vinegar is absorbed by Coptis chinensis. Then stir-fry over a low flame at 100 degrees Celsius for 30 minutes until the surface of Coptis chinensis is dry and not sticky. This is how you get processed Coptis chinensis.

[0063] (4) Slice the Scutellaria baicalensis to obtain slices with a thickness of 2 mm. Take 100 grams of the slices and spray them with 8 grams of rice wine. Then, moisten them at 35 degrees Celsius for 5 hours and air dry them to obtain processed Scutellaria baicalensis.

[0064] (5) Wash 100g of lotus leaf shreds and set aside. Spray 18g of refined honey onto the lotus leaf shreds, stir and mix, let it sit at 25 degrees Celsius for 30 minutes, then stir-fry the lotus leaf at 116 degrees Celsius until the surface turns dark yellow and you can smell the aroma of honey. After stir-frying, remove it from the pan, spread it out to cool, and you will get the prepared lotus leaf.

[0065] (6) Take the bark, root bark, and branch bark of Magnolia officinalis, scrape off the rough bark, and wash it clean. Soak the washed Magnolia officinalis in water for 2 hours, cut it into strips, and sun-dry it. Boil 100 grams of Magnolia officinalis and 12 grams of ginger together until the ginger juice is absorbed, then dry it to obtain processed Magnolia officinalis.

[0066] (7) Weigh out the following parts by weight: 32 parts of processed Asparagus root, 32 parts of processed Ophiopogon japonicus root, 48 parts of processed Coptis chinensis root, 47 parts of processed Scutellaria baicalensis root, 47 parts of processed Nelumbo nucifera leaf, 62 parts of Trichosanthes kirilowii root, 62 parts of Anemarrhena asphodeloides rhizome (5 cm thick slices), 10 parts of American ginseng (0.3 mm thick slices), 10 parts of red yeast rice, 18 parts of dried ginger (4 mm thick slices), and 32 parts of processed Magnolia officinalis bark.

[0067] (8) The processed Asparagus, processed Ophiopogon japonicus, processed Coptis chinensis, processed Scutellaria baicalensis, processed Nelumbo nucifera leaf, processed Magnolia officinalis, Trichosanthes kirilowii, Anemarrhena asphodeloides, American ginseng, red yeast rice and dried ginger were soaked in 8 times the amount of water (the ratio of the total mass of processed Asparagus, processed Ophiopogon japonicus, processed Coptis chinensis, processed Scutellaria baicalensis, processed Nelumbo nucifera leaf, processed Magnolia officinalis, Trichosanthes kirilowii, Anemarrhena asphodeloides, American ginseng, red yeast rice and dried ginger to the mass of water was 1:8, the same below) at room temperature (35 degrees Celsius) for 30 minutes. Then the soaked medicinal materials and water were boiled and kept boiling for 45 minutes to concentrate 3 times to obtain the anti-diabetic Chinese medicine composition.

[0068] Example 2 This embodiment prepares a traditional Chinese medicine composition for treating diabetes. Steps (1) to (6) do not have a specific time order requirement. The specific steps are as follows: (1) Steam the asparagus at normal pressure for 40 minutes. After steaming, peel the asparagus to obtain processed asparagus.

[0069] (2) Dilute the honey with water at 100 degrees Celsius so that the honey can adhere to the surface of Ophiopogon japonicus; mix 100 grams of Ophiopogon japonicus with the diluted honey (of which the mass of honey is 15 grams), and then stir-fry over a low flame at 100 degrees Celsius for 35 minutes until the surface of Ophiopogon japonicus turns yellow and is not sticky, thus obtaining processed Ophiopogon japonicus.

[0070] (3) Mix 100g of Coptis chinensis and 10g of rice vinegar and let it soak for 2 hours until the rice vinegar is absorbed by Coptis chinensis. Then stir-fry over low heat at 80 degrees Celsius for 50 minutes until the surface of Coptis chinensis is dry and not sticky. This is how you get processed Coptis chinensis.

[0071] (4) Slice the Scutellaria baicalensis to obtain slices with a thickness of 2 mm. Take 100 grams of the slices and spray them with 8 grams of rice wine. Then, moisten them at 35 degrees Celsius for 7 hours and air dry them to obtain processed Scutellaria baicalensis.

[0072] (5) Wash 100g of lotus leaf shreds and set aside. Spray 15g of refined honey onto the lotus leaf shreds, stir and mix, let it sit at 15 degrees Celsius for 50 minutes, then stir-fry the lotus leaf at 118 degrees Celsius until the surface turns dark yellow and you can smell the aroma of honey. After stir-frying, remove it from the pan, spread it out to cool, and you will get the prepared lotus leaf.

[0073] (6) Take the bark, root bark, and branch bark of Magnolia officinalis, scrape off the rough bark, and wash it clean. Soak the washed Magnolia officinalis in water for 5 hours, cut it into strips, and sun-dry it. Boil 100 grams of Magnolia officinalis with 12 grams of ginger until the ginger juice is absorbed, then dry it to obtain processed Magnolia officinalis.

[0074] (7) Weigh out the following parts by weight: 28 parts of processed Asparagus cochinchinensis, 28 parts of processed Ophiopogon japonicus, 42 parts of processed Coptis chinensis, 43 parts of processed Scutellaria baicalensis, 43 parts of processed Nelumbo nucifera leaf, 58 parts of Trichosanthes kirilowii, 57 parts of Anemarrhena asphodeloides (8 cm thick slices), 8 parts of American ginseng (0.2 mm thick slices), 9 parts of red yeast rice, 12 parts of dried ginger (2 mm thick slices), and 28 parts of processed Magnolia officinalis.

[0075] (8) The processed Asparagus, processed Ophiopogon japonicus, processed Coptis chinensis, processed Scutellaria baicalensis, processed Nelumbo nucifera, processed Magnolia officinalis, Trichosanthes kirilowii, Anemarrhena asphodeloides, American ginseng, red yeast rice and dried ginger were soaked in 13 times the amount of water at room temperature (35 degrees Celsius) for 50 minutes. Then the soaked herbs and water were boiled and kept boiling for 45 minutes to concentrate the mixture by 4 times to obtain the anti-diabetic Chinese medicine composition.

[0076] Example 3 This embodiment prepares a traditional Chinese medicine composition for treating diabetes. Steps (1) to (6) do not have a specific time order requirement. The specific steps are as follows: (1) Steam the asparagus at normal pressure for 37 minutes. After steaming, peel the asparagus to obtain processed asparagus.

[0077] (2) Dilute the honey with 100°C water so that the honey can adhere to the surface of Ophiopogon japonicus; mix 100g of Ophiopogon japonicus with the diluted honey (of which the honey weighs 15g), and then stir-fry over a low flame at 95°C for 38 minutes until the surface of Ophiopogon japonicus turns yellow and is no longer sticky, thus obtaining processed Ophiopogon japonicus.

[0078] (3) Mix 100g of Coptis chinensis and 12g of rice vinegar and let it soak for 3 hours until the rice vinegar is absorbed by Coptis chinensis. Then stir-fry over a low flame at 90 degrees Celsius for 40 minutes until the surface of Coptis chinensis is dry and not sticky. This is how you get processed Coptis chinensis.

[0079] (4) Slice the Scutellaria baicalensis to obtain slices with a thickness of 1 mm. Take 100 grams of the slices and spray them with 11 grams of rice wine. Then, let them sit at 32 degrees Celsius for 7 hours and dry them to obtain processed Scutellaria baicalensis.

[0080] (5) Wash 100g of lotus leaf shreds and set aside. Spray 18g of refined honey onto the lotus leaf shreds, stir and mix, let it sit at 25 degrees Celsius for 30 minutes, then stir-fry the lotus leaf at 118 degrees Celsius until the surface turns dark yellow and you can smell the aroma of honey. After stir-frying, remove it from the pan, spread it out to cool, and you will get the prepared lotus leaf.

[0081] (6) Take the bark, root bark, and branch bark of Magnolia officinalis, scrape off the rough bark, and wash it clean. Soak the washed Magnolia officinalis in water for 2 hours, cut it into strips, and sun-dry it. Boil 100 grams of Magnolia officinalis and 12 grams of ginger together until the ginger juice is absorbed, then dry it to obtain processed Magnolia officinalis.

[0082] (7) Weigh out the following ingredients according to their weight: 30 parts of processed Asparagus root, 30 parts of processed Ophiopogon japonicus root, 45 parts of processed Coptis chinensis root, 45 parts of processed Scutellaria baicalensis root, 45 parts of processed Nelumbo nucifera leaf, 60 parts of Trichosanthes kirilowii root, 60 parts of Anemarrhena asphodeloides rhizome (7 cm thick slices), 9 parts of American ginseng (0.2 mm thick slices), 9 parts of red yeast rice, 15 parts of dried ginger (3 mm thick slices), and 30 parts of processed Magnolia officinalis bark.

[0083] (8) The processed Asparagus, processed Ophiopogon japonicus, processed Coptis chinensis, processed Scutellaria baicalensis, processed Nelumbo nucifera, processed Magnolia officinalis, Trichosanthes kirilowii, Anemarrhena asphodeloides, American ginseng, red yeast rice and dried ginger were soaked in 10 times the amount of water at room temperature (31 degrees Celsius) for 40 minutes. Then the soaked herbs and water were boiled and kept boiling for 35 minutes to concentrate the mixture by 3 times to obtain the anti-diabetic Chinese medicine composition.

[0084] Example 4 This embodiment prepares a traditional Chinese medicine composition for treating diabetes. Steps (1) to (6) do not have a specific time order requirement. The specific steps are as follows: (1) Steam the asparagus at normal pressure for 40 minutes. After steaming, peel the asparagus to obtain processed asparagus.

[0085] (2) Dilute the honey with water at 100 degrees Celsius so that the honey can adhere to the surface of Ophiopogon japonicus; mix 100 grams of Ophiopogon japonicus with the diluted honey (of which the honey weighs 15 grams), and then stir-fry over a low flame at 95 degrees Celsius for 37 minutes until the surface of Ophiopogon japonicus turns yellow and is no longer sticky, thus obtaining processed Ophiopogon japonicus.

[0086] (3) Mix 100g of Coptis chinensis and 12g of rice vinegar and let it soak for 3 hours until the rice vinegar is absorbed by Coptis chinensis. Then stir-fry over a low flame at 90 degrees Celsius for 45 minutes until the surface of Coptis chinensis is dry and not sticky. This is how you get processed Coptis chinensis.

[0087] (4) Slice the Scutellaria baicalensis to obtain slices with a thickness of 2 mm. Take 100 grams of the slices and spray them with 8 grams of rice wine. Then, moisten them at 35 degrees Celsius for 6 hours and air dry them to obtain processed Scutellaria baicalensis.

[0088] (5) Wash 100g of lotus leaf shreds and set aside. Spray 18g of refined honey onto the lotus leaf shreds, stir and mix, let it sit at 25 degrees Celsius for 30 minutes, then stir-fry the lotus leaf at 116 degrees Celsius until the surface turns dark yellow and you can smell the aroma of honey. After stir-frying, remove it from the pan, spread it out to cool, and you will get the prepared lotus leaf.

[0089] (6) Take the bark, root bark, and branch bark of Magnolia officinalis, scrape off the rough bark, and wash it clean. Soak the washed Magnolia officinalis in water for 2 hours, cut it into strips, and sun-dry it. Boil 100 grams of Magnolia officinalis and 12 grams of ginger together until the ginger juice is absorbed, then dry it to obtain processed Magnolia officinalis.

[0090] (7) Weigh out the following parts by weight: 32 parts of processed Asparagus root, 30 parts of processed Ophiopogon japonicus root, 45 parts of processed Coptis chinensis root, 45 parts of processed Scutellaria baicalensis root, 47 parts of processed Nelumbo nucifera leaf, 60 parts of Trichosanthes kirilowii root, 60 parts of Anemarrhena asphodeloides rhizome (7 cm thick slices), 9 parts of American ginseng (0.3 mm thick slices), 9 parts of red yeast rice, 15 parts of dried ginger (3 mm thick slices), and 30 parts of processed Magnolia officinalis bark.

[0091] (8) The processed Asparagus, processed Ophiopogon japonicus, processed Coptis chinensis, processed Scutellaria baicalensis, processed Nelumbo nucifera, processed Magnolia officinalis, Trichosanthes kirilowii, Anemarrhena asphodeloides, American ginseng, red yeast rice and dried ginger were soaked in 11 times the amount of water at room temperature (25 degrees Celsius) for 35 minutes. Then the soaked herbs and water were boiled and kept boiling for 35 minutes to concentrate the mixture by 4 times to obtain the anti-diabetic Chinese medicine composition.

[0092] Example 5 This embodiment prepares a traditional Chinese medicine composition for treating diabetes. Steps (1) to (6) do not have a specific time order requirement. The specific steps are as follows: (1) Steam the asparagus at normal pressure for 37 minutes. After steaming, peel the asparagus to obtain processed asparagus.

[0093] (2) Dilute the honey with water at 100 degrees Celsius so that the honey can adhere to the surface of Ophiopogon japonicus; mix 100 grams of Ophiopogon japonicus with the diluted honey (of which the honey weighs 12 grams), and then stir-fry over a low flame at 95 degrees Celsius for 36 minutes until the surface of the Ophiopogon japonicus turns yellow and is no longer sticky, thus obtaining the processed Ophiopogon japonicus.

[0094] (3) Mix 100g of Coptis chinensis and 13g of rice vinegar and let it soak for 3 hours until the rice vinegar is absorbed by Coptis chinensis. Then stir-fry over a low flame at 90 degrees Celsius for 40 minutes until the surface of Coptis chinensis is dry and not sticky. This is how you get processed Coptis chinensis.

[0095] (4) Slice the Scutellaria baicalensis to obtain slices with a thickness of 1 mm. Take 100 grams of the slices and spray them with 11 grams of rice wine. Then, let them sit at 35 degrees Celsius for 6 hours and dry them to obtain processed Scutellaria baicalensis.

[0096] (5) Wash 100g of lotus leaf shreds and set aside. Spray 18g of refined honey onto the lotus leaf shreds, stir and mix, let it sit at 15 degrees Celsius for 50 minutes, then stir-fry the lotus leaf at 116 degrees Celsius until the surface turns dark yellow and you can smell the aroma of honey. After stir-frying, remove it from the pan, spread it out to cool, and you will get the prepared lotus leaf.

[0097] (6) Take the bark, root bark, and branch bark of Magnolia officinalis, scrape off the rough bark, and wash it clean. Soak the washed Magnolia officinalis in water for 4 hours, cut it into strips, and sun-dry it. Boil 100 grams of Magnolia officinalis and 10 grams of ginger together until the ginger juice is absorbed, then dry it to obtain processed Magnolia officinalis.

[0098] (7) Weigh out the following parts by weight: 32 parts of processed Asparagus cochinchinensis, 32 parts of processed Ophiopogon japonicus, 42 parts of processed Coptis chinensis, 43 parts of processed Scutellaria baicalensis, 47 parts of processed Nelumbo nucifera leaf, 62 parts of Trichosanthes kirilowii, 62 parts of Anemarrhena asphodeloides (8 cm thick slices), 8 parts of American ginseng (0.3 mm thick slices), 8 parts of red yeast rice, 12 parts of dried ginger (4 mm thick slices), and 28 parts of processed Magnolia officinalis.

[0099] (8) The processed Asparagus, processed Ophiopogon japonicus, processed Coptis chinensis, processed Scutellaria baicalensis, processed Nelumbo nucifera, processed Magnolia officinalis, Trichosanthes kirilowii, Anemarrhena asphodeloides, American ginseng, red yeast rice and dried ginger were soaked in 9 times the amount of water at room temperature (35 degrees Celsius) for 50 minutes. Then the soaked herbs and water were boiled and kept boiling for 45 minutes to concentrate the mixture by 2 times to obtain the anti-diabetic Chinese medicine composition.

[0100] Comparative Example 1 The preparation method of this comparative example is the same as that of Example 1, except that Coptis chinensis is processed by conventional wine-processing.

[0101] Comparative Example 2 The preparation method of this comparative example is the same as that of Example 1, except that Scutellaria baicalensis is processed by conventional honey-processing.

[0102] Comparative Example 3 The preparation method of this comparative example is the same as that of Example 1, except that Anemarrhena asphodeloides is not added.

[0103] Comparative Example 4 The preparation method of this comparative example is the same as that of Example 1, except that dried ginger is not added.

[0104] Comparative Example 5 The preparation method of this comparative example is the same as that of Example 1, except that 70 parts of Trichosanthes kirilowii pollen are added.

[0105] Test Example 1 The antidiabetic traditional Chinese medicine compositions prepared in Examples 1-5 and Comparative Examples 1-5 of this invention were subjected to antidiabetic tests, and the specific test methods are as follows: This test recruited 360 diabetic patients as volunteers, who were randomly divided into three groups: experimental groups 1-5 (who took the anti-diabetic traditional Chinese medicine composition prepared in Examples 1-5, twice a day, 50 ml each time), control groups 1-6 (who took the anti-diabetic traditional Chinese medicine composition prepared in Examples 1-5 or anti-diabetic Western medicine, respectively; the anti-diabetic traditional Chinese medicine composition prepared in Examples 1-5 was taken twice a day, 50 ml each time, and the anti-diabetic Western medicine was taken according to its instructions), and a blank group (who took normal saline, twice a day, 50 ml each time). Each group had 30 diabetic patients. The diabetic patients in Examples 1-5, control groups 1-6, and the blank group were unaware of any differences in medication among themselves. The symptoms, disease course, age, and gender of the 12 groups were statistically comparable (P > 0.05). The test was conducted continuously for 60 days. Changes in diabetic indicators such as mean fasting blood glucose were measured at three time points (before breakfast on each day): before grouping, on day 30 of medication, and on day 60 of medication. The results are shown in Table 1.

[0106] Table 1: Results of the antidiabetic test in Test Example 1

[0107] As can be seen from Table 1, the anti-diabetic traditional Chinese medicine composition provided in this embodiment of the invention has obvious therapeutic effects on diabetes. After 30 days of medication, the average fasting blood glucose decreased by more than 12%, and after 60 days of medication, the average fasting blood glucose decreased by more than 23%, which is significant and far superior to the 6 control groups and the blank group.

[0108] Furthermore, the clinical symptoms of volunteers who took the anti-diabetic traditional Chinese medicine composition of the present invention improved significantly, their patient experience improved, no obvious side effects were found, and the overall blood sugar lowering effect was significant.

[0109] The embodiments of the present invention have been described above; however, these embodiments are merely illustrative and not intended to limit the scope of the invention. Although various embodiments have been described above, this does not mean that the measures in the embodiments cannot be used advantageously in combination. Various substitutions and modifications can be made by those skilled in the art without departing from the scope of the invention, and all such substitutions and modifications should fall within the scope of the invention.

Claims

1. A method for preparing a traditional Chinese medicine composition for treating diabetes, characterized in that, Includes the following steps: (1) Raw material processing: Steaming the asparagus to obtain processed asparagus; Processed Ophiopogon japonicus is obtained by honey-frying Ophiopogon japonicus. Coptis chinensis is vinegar-processed and then dried to obtain processed Coptis chinensis. Scutellaria baicalensis is sliced ​​to obtain Scutellaria baicalensis slices. The Scutellaria baicalensis slices are then sprayed with rice wine, moistened and dried to obtain processed Scutellaria baicalensis. After mixing lotus leaves and refined honey and soaking them in water, they are stir-fried and dried in sequence to obtain processed lotus leaves. Magnolia officinalis is boiled with ginger until the ginger juice is absorbed, and then dried to obtain processed Magnolia officinalis. (2) Weighing of raw materials: Weigh 28-32 parts of processed Asparagus root, 28-32 parts of processed Ophiopogon japonicus root, 42-48 parts of processed Coptis chinensis root, 43-47 parts of processed Scutellaria baicalensis root, 43-47 parts of processed Nelumbo nucifera leaf, 58-62 parts of Trichosanthes kirilowii root, 57-62 parts of Anemarrhena asphodeloides rhizome, 8-10 parts of American ginseng root, 8-10 parts of red yeast rice, 12-18 parts of dried ginger root, and 28-32 parts of processed Magnolia officinalis root according to the mass fraction; (3) The processed Asparagus, processed Ophiopogon japonicus, processed Coptis chinensis, processed Scutellaria baicalensis, processed Nelumbo nucifera leaf, processed Magnolia officinalis, Trichosanthes kirilowii, Anemarrhena asphodeloides, American ginseng, red yeast rice and dried ginger are soaked in water and then decocted and concentrated in sequence to obtain a traditional Chinese medicine composition for antidiabetic diseases.

2. The preparation method according to claim 1, characterized in that, The steaming pressure is atmospheric pressure, and the time is 35-40 minutes.

3. The preparation method according to claim 1, characterized in that, The honey-processing process includes the following steps: mixing Ophiopogon japonicus with diluted refined honey and then stir-frying until the surface of the Ophiopogon japonicus turns yellow and is no longer sticky.

4. The preparation method according to claim 3, characterized in that, The mass ratio of Ophiopogon japonicus to refined honey is 100:10~15.

5. The preparation method according to claim 1, characterized in that, The vinegar preparation includes the following steps: mixing Coptis chinensis and rice vinegar, soaking and then stir-frying until the surface is dry and not sticky.

6. The preparation method according to claim 5, characterized in that, The mass ratio of Coptis chinensis to rice vinegar is 100:10~14.

7. The preparation method according to claim 1, characterized in that, The lotus leaf is lotus leaf filament; the mass ratio of the lotus leaf to refined honey is 100:15~18.

8. The preparation method according to claim 1, characterized in that, The raw materials are weighed in the following proportions by weight: 30 parts of processed Asparagus root, 30 parts of processed Ophiopogon root, 45 parts of processed Coptis root, 45 parts of processed Scutellaria root, 45 parts of processed lotus leaf, 60 parts of Trichosanthes root, 60 parts of Anemarrhena rhizome, 9 parts of American ginseng, 9 parts of red yeast rice, 15 parts of dried ginger, and 30 parts of processed Magnolia bark.

9. The preparation method according to claim 1, characterized in that, The ratio of the total mass of the processed Asparagus root, processed Ophiopogon root, processed Coptis root, processed Scutellaria root, processed lotus leaf, processed Magnolia bark, Trichosanthes root, Anemarrhena rhizome, American ginseng, red yeast rice, and dried ginger to the mass of water is 1:8~13; the concentration factor is 2~4 times.

10. The preparation method according to claim 1, characterized in that, The decoction process includes the following steps: boiling the soaked herbs and water and then keeping them at a boil; the boiling time is 30-45 minutes.

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