A soluble liquid phase carrier for polypeptide liquid phase synthesis and use thereof

By using a piperidine-methanol soluble liquid carrier, the problems of poor solubility and precipitation state of liquid-phase synthesis carriers are solved, achieving efficient and low-cost peptide synthesis, which is suitable for the synthesis of various solvents and long peptide chains.

CN121990981BActive Publication Date: 2026-07-03CHENGDU SAIKELUO BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
CHENGDU SAIKELUO BIOTECHNOLOGY CO LTD
Filing Date
2026-04-10
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

Existing liquid-phase synthesis carriers have poor solubility in conventional reagents, poor crystal precipitation, and are difficult to wash, resulting in low peptide synthesis efficiency and low purity. In addition, they use highly toxic solvents, which increases costs.

Method used

Soluble liquid carriers with piperidine methanol structures, such as compounds A1 and B1, are used. They have good solubility in a variety of common organic solvents, and after the reaction, they present good solid particle state, which is convenient for filtration and washing. They are also stable for linking to peptides under mild conditions, which is convenient for reaction monitoring.

Benefits of technology

It improves the solubility and precipitation state of peptide liquid-phase synthesis, simplifies the washing process, reduces costs, improves synthesis efficiency and purity, has wide applicability, and is suitable for the synthesis of long peptide chains.

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Abstract

This invention belongs to the technical field of peptide liquid-phase synthesis carriers, and discloses a soluble liquid-phase carrier for peptide liquid-phase synthesis and its application. The structural formula of the soluble liquid-phase carrier for peptide liquid-phase synthesis is as follows, wherein: the group R is selected from H, methoxy, halogen, alkyl, aldehyde, and nitro groups, and the number is 1-3; the number of Linker-Tag groups is 1-3. When the soluble liquid-phase carrier of this invention is applied to peptide liquid-phase synthesis, it not only exhibits excellent performance in improving operational efficiency and facilitating reaction monitoring, but also has the advantages of economy and sustainable use. It can significantly improve the efficiency and controllability of the peptide liquid-phase synthesis process and has strong practicality.
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Citation Information

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