Wound repair composite formulation based on fgf2 variants and uses thereof
By developing an NGF2 mutant with improved thermal stability and extended half-life and combining it with a moisturizing cream, the problems of heat intolerance and unstable activity of natural FGF2 protein were solved, achieving the effects of reducing application frequency and improving the durability of wound repair.
CN122140606APending Publication Date: 2026-06-05TRIUMPH WORLD GROUP CO LTD
Patent Information
- Application Number
- CN202511558985.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-10-29
- Publication Date
- 2026-06-05
AI Technical Summary
Technical Problem
Natural FGF2 protein is heat-sensitive and has unstable activity, leading to the need for frequent administration or injection. Furthermore, it is difficult to maintain its biological activity at room temperature, which limits its practical application.
Method used
An NGF2 mutant was developed using protein engineering technology to improve its thermal stability and room temperature half-life. This mutant was then mixed with a water-based cream to form a compound formulation that prolongs the effective duration of action at the wound site.
Benefits of technology
It reduces the frequency of application, improves the durability of wound repair, and significantly accelerates skin wound healing, especially for chronic wounds such as diabetic foot ulcers.
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Figure CN122140606A_ABST
Abstract
The application discloses a kind of wound repair composite preparation based on FGF2 variant and its application, it is related to the technical field of skin wound repair biological preparation, the composite preparation is composed of active ingredient and matrix, the active ingredient is FGF2 mutant, the matrix is cream.The FGF2 mutant is NGF2 protein, the NGF2 protein is obtained by protein engineering technology to natural FGF2 is reformed;The NGF2 protein has high thermal stability and extended normal temperature half-life.The cream is preferably water cream (Basic Aquacream).In the application, NGF2 and water cream synergistically, extend the local action time of protein, realize the effect of reducing the frequency of smearing, enhance repair durability.Preparation can effectively promote wound granulation tissue formation, angiogenesis and collagen remodeling, improve healing quality and reduce scar, provide reliable scheme for the development of new generation wound repair biological preparation.
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Citation Information
Patent Citations
A fusion protein ngf2 with improved half-life in vivo and its use
CN122145644A