A pyrazolo pyridine compound, and a preparation method and application thereof

By preparing pyrazolopyridine compounds, the problem of unsatisfactory effects of existing cardioprotective drugs has been solved, achieving a protective effect on cardiomyocytes, enhancing cell activity and reducing inflammatory response, and providing novel candidate compounds for cardioprotective drugs.

CN122586884APending Publication Date: 2026-08-18ZHENGZHOU UNIV
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Patent Information

Application Number
CN202610677470.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-18
Publication Date
2026-08-18

AI Technical Summary

Technical Problem

Existing cardioprotective drugs are not effective in treating myocardial infarction and myocardial ischemia-reperfusion injury, and are often accompanied by adverse reactions. There is a lack of effective cardioprotective candidate compounds in clinical practice.

Method used

A novel pyrazolopyridine compound was developed and prepared via a specific synthetic route. This compound enhances cardiomyocyte activity, reduces lactate dehydrogenase release, decreases pro-inflammatory factor expression, and provides cardioprotective effects.

Benefits of technology

Pyrazolopyridine compounds significantly protect damaged cardiomyocytes, enhance cell activity, and reduce inflammatory responses. They also provide a high-yield and high-purity preparation method, offering a theoretical basis for the development of cardioprotective drugs.

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Abstract

The application belongs to the technical field of medicine synthesis, and particularly relates to a pyrazolopyridine compound and a preparation method and application thereof. The pyrazolopyridine compound provided by the application has a structure as shown in formula I. The pyrazolopyridine compound provided by the application has obvious protection on damaged myocardial cells. Meanwhile, the compound can play an effective myocardial protection role by improving myocardial cell activity, reducing lactate dehydrogenase release, and reducing the expression of pro-inflammatory factors TNF-alpha, IL-18, IL-1beta and IL-6. Therefore, the application not only enriches the molecular bank of myocardial protection drugs, and provides a theoretical basis and a candidate skeleton for developing a new myocardial protection drug, and has a wide application prospect in the preparation of the pyrazolopyridine compound and the development of a myocardial protection drug with more excellent activity.
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