Micro-injection pump for brain stereotactic injection

Abstract

The utility model relates to the technical field of scientific research, and discloses a micro-injection pump for brain stereotactic injection, which comprises a base and a controller, the top of the base is rotatably connected with a rotating seat, the top of the rotating seat is fixedly connected with a supporting wheel, the top of the supporting wheel is fixedly connected with a first supporting frame, and the first supporting frame is fixedly connected with a second supporting frame. The top of the first supporting frame is rotationally connected with a first one-way threaded rod, the top of the first one-way threaded rod is rotationally connected with a second supporting frame, the periphery of the first one-way threaded rod is in threaded connection with a movable frame, the interior of the movable frame is in threaded connection with a second one-way threaded rod, and the left side of the second one-way threaded rod is rotationally connected with a first sliding frame. The right side of the first sliding frame is rotationally connected with a second sliding frame. According to the utility model, the rotating handle, the rotating handle I and the rotating handle II can be sequentially rotated, so that the angle, the height and the horizontal position of the injector can be adjusted, the injector can be more accurately aligned with a target brain region, and the flexibility of equipment is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of scientific research, in particular to a microinjection pump for brain stereotactic injection. Background Art

[0002] Stereotaxic injection involves precisely targeting a needle tip into a specific brain region in a small animal using precise surgical techniques, followed by the injection of drugs or other substances. This technique is often used to study the impact of specific neural circuits or brain regions on behavioral, cognitive, or physiological processes. Through stereotaxic injection, researchers can explore the functions and regulatory mechanisms of the nervous system, gaining a deeper understanding of how the brain works and the pathogenesis of related diseases.

[0003] Microsyringe pumps provide precise drug delivery, ensuring accurate and stable drug delivery during stereotaxic brain injections. This precision is crucial for studying the effects of specific neural circuits and reduces errors introduced by manual injections. Furthermore, microsyringe pumps can automate drug delivery, reducing operator labor costs and improving experimental reproducibility and accuracy.

[0004] However, the existing technology cannot well control the injection needle to accurately align with the target brain area and accurately control the injection volume and injection speed, which makes the equipment more inconvenient to use. Therefore, a microinjection pump for brain stereotactic injection is proposed to solve the above problems. Utility Model Content

[0005] In order to make up for the above shortcomings, the utility model provides a micro-injection pump for stereotactic brain injection, which aims to improve the problem in the existing technology that the injection needle cannot be well controlled to accurately align with the target brain area and accurately control the injection volume and injection speed.

[0006] In order to achieve the above-mentioned purpose, the utility model adopts the following technical scheme: a micro-injection pump for stereotactic brain injection, comprising a base and a controller, the top of the base is rotatably connected to a rotating seat, the top of the rotating seat is fixedly connected to a support wheel, the top of the support wheel is fixedly connected to a support frame 1, the top of the support frame 1 is rotatably connected to a one-way threaded rod 1, the top of the one-way threaded rod 1 is rotatably connected to a support frame 2, the outer periphery of the one-way threaded rod 1 is threadedly connected to a movable frame, the internal thread of the movable frame is threadedly connected to a one-way threaded rod 2, the left side of the one-way threaded rod 2 is rotatably connected to a sliding frame 1, the right side of the sliding frame 1 is rotatably connected to a sliding frame 2, the front end of the sliding frame 2 is fixedly connected to a connecting frame, the right side of the connecting frame is fixedly connected to a fixed frame, a control component is provided on the top of the fixed frame, and a clamping component is provided inside the fixed frame.

[0007] Through the above technical solution, the height of the syringe can be adjusted by rotating the one-way threaded rod 1, the lateral position of the syringe can be adjusted by rotating the one-way threaded rod 2, and the tilt angle of the syringe can be adjusted by rotating the support wheel.

[0008] Furthermore, the control component includes a reducer, which is fixedly connected to the top of the fixed frame, and a motor is fixedly connected to the top of the reducer. The output end of the motor is fixedly connected to a one-way threaded rod three, and the outer periphery of the one-way threaded rod three is threadedly connected to a sliding block, and the motor is electrically connected to the controller.

[0009] Through the above technical solution, the motor can be started to drive the one-way threaded rod three to rotate, thereby causing the sliding block to move up and down, and the reducer is used to enable the motor to control the sliding block more flexibly.

[0010] Furthermore, the clamping assembly includes two bidirectional threaded rods, both of which are rotatably connected to the inside of the fixed frame, and the outer periphery of the two bidirectional threaded rods are threadedly connected to two moving blocks, and the front ends of the two moving blocks are fixedly connected to clamps, and the two clamps are abutted against syringes on opposite sides, the top of the syringe is slidably connected to a piston rod, and the bottom of the syringe is fixedly connected to a guide tube.

[0011] Through the above technical solution, the bidirectional threaded rod can be rotated to drive the clamping hand to clamp the syringe, thereby improving the efficiency of installing and removing the syringe.

[0012] Furthermore, the support frame 1 and the support frame 2 are fixedly connected to two connecting rods 1 on the side facing each other, and the movable frame is slidably connected to the outer periphery of the two connecting rods 1. The sliding frame 1 and the sliding frame 2 are fixedly connected to two connecting rods 2 on the side facing each other, and the movable frame is slidably connected to the outer periphery of the two connecting rods 2.

[0013] Through the above technical solution, the movement of the movable frame on the one-way threaded rod 1 and the one-way threaded rod 2 can be made more stable.

[0014] Furthermore, a turning handle is fixedly connected to the left side of the support wheel, a turning handle 1 is fixedly connected to the top of the one-way threaded rod 1, and a turning handle 2 is fixedly connected to the left side of the one-way threaded rod 2.

[0015] Through the above technical solution, the turning handle is used to better operate the tilt angle, the turning hand one can better control the one-way threaded rod one, and the turning hand two can better control the two-way threaded rod two.

[0016] Furthermore, the sliding block is slidably connected to the interior of the fixing frame, and the sliding block abuts against two ends of the piston rod.

[0017] Through the above technical solution, the piston rod of the syringe is arranged on the sliding block to control the injection volume and injection speed.

[0018] Furthermore, the plurality of moving blocks are all slidably connected to the interior of the fixing frame, and the left sides of the two bidirectional threaded rods are both fixedly connected with a third hand.

[0019] Through the above technical solution, the third hand can better control the bidirectional threaded rod.

[0020] Furthermore, a display is fixedly connected to the front end of the controller.

[0021] Through the above technical solution, the display can better monitor the equipment.

[0022] The utility model has the following beneficial effects:

[0023] 1. In the present invention, the tilt angle of the fixing frame can be adjusted by rotating the handle, thereby adjusting the angle of the syringe. The height of the fixing frame can also be changed by rotating the one-way threaded rod one, thereby adjusting the height of the syringe. The horizontal position of the fixing frame can be changed by rotating the one-way threaded rod two, thereby changing the position of the syringe. The above operations can accurately align the syringe with the position where injection is required, thereby improving the accuracy of the syringe injection position.

[0024] 2. In the present invention, the motor can be started to drive the one-way threaded rod 2 to rotate, and the reducer can enable the motor to control the one-way threaded rod 2 more sensitively. When the one-way threaded rod 2 rotates, the sliding block can be driven to move up and down, thereby driving the piston rod of the syringe to move, so that the injection volume and injection speed can be accurately controlled. Moreover, by rotating the turning handle 3, the clamping hand can be quickly no longer fixed on the syringe, thereby improving the efficiency of disassembling and installing the syringe. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 This is a three-dimensional schematic diagram of a microinjection pump for stereotactic brain injection proposed by the utility model;

[0026] Figure 2 This is a schematic structural diagram of a mobile frame of a microinjection pump for stereotactic brain injection proposed by the present invention;

[0027] Figure 3 This is a schematic structural diagram of a sliding block of a microinjection pump for stereotactic brain injection proposed by the present invention;

[0028] Figure 4 The utility model is a schematic structural diagram of a microinjection pump for stereotactic brain injection.

[0029] Legend:

[0030] 1. Base; 2. Rotating seat; 3. Support wheel; 4. Turning handle; 5. Support frame 1; 6. One-way threaded rod 1; 7. Support frame 2; 8. Connecting rod 1; 9. Turning handle 1; 10. Moving frame; 11. One-way threaded rod 2; 12. Sliding frame 1; 13. Sliding frame 2; 14. Connecting rod 2; 15. Turning handle 2; 16. Connecting frame; 17. Fixed frame; 18. One-way threaded rod 3; 19. Sliding block; 20. Reducer; 21. Motor; 22. Two-way threaded rod; 23. Moving block; 24. Clamping handle; 25. Turning handle 3; 26. Syringe; 27. Piston rod; 28. Guide tube; 29. ​​Controller. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0032] Reference Figure 1 - Figure 2 , the utility model provides an embodiment: a micro-injection pump for brain stereotactic injection, including a base 1 and a controller 29, the top of the base 1 is rotatably connected to a rotating base 2, the top of the rotating base 2 is fixedly connected to a supporting wheel 3, the top of the supporting wheel 3 is fixedly connected to a supporting frame 5, the top of the supporting frame 5 is rotatably connected to a one-way threaded rod 6, the top of the one-way threaded rod 6 is rotatably connected to a supporting frame 2 7, the outer periphery of the one-way threaded rod 6 is threadedly connected to a mobile frame 10, the internal thread of the mobile frame 10 is threadedly connected to a one-way threaded rod 2 11, the left side of the one-way threaded rod 2 11 is rotatably connected to a sliding frame 12, the right side of the sliding frame 12 is rotatably connected to a sliding frame 2 13, and the front end of the sliding frame 2 13 is fixedly connected It is connected to a connecting frame 16, and a fixed frame 17 is fixedly connected to the right side of the connecting frame 16. A control component is provided on the top of the fixed frame 17, and a clamping component is provided inside the fixed frame 17. The supporting frame 15 is fixedly connected to two connecting rods 8 on the opposite side of the supporting frame 2 7. The mobile frame 10 is slidably connected to the outer periphery of the two connecting rods 8. The sliding frame 12 is fixedly connected to two connecting rods 2 14 on the opposite side of the sliding frame 2 13. The mobile frame 10 is slidably connected to the outer periphery of the two connecting rods 2 14. The left side of the support wheel 3 is fixedly connected to the turning handle 4, the top of the one-way threaded rod 16 is fixedly connected to the turning hand 19, the left side of the one-way threaded rod 2 11 is fixedly connected to the turning hand 2 15, and the front end of the controller 29 is fixedly connected to a display.

[0033] Specifically, the base 1 is used to place and fix the entire device, a rotating seat 2 is set on the top of the base 1 to drive the entire device to rotate, a supporting wheel 3 is set on the top of the rotating seat 2, and the supporting wheel 3 is used to adjust the angle of the device. A turning handle 4 is set on the left side of the supporting wheel 3 for the operator to better rotate the supporting wheel 3. A supporting frame 5 is fixed on the top of the supporting wheel 3, and the supporting frame 5 is used to support the one-way threaded rod 6. A rotating one-way threaded rod 6 is set on the top of the supporting frame 5, and the one-way threaded rod 6 is used to drive the moving frame 10 to move up and down. A supporting frame 2 7 is set on the top of the one-way threaded rod 6 to cooperate with the supporting frame 5 to support the one-way threaded rod 6. A connecting rod 18 is set between 15 and the supporting frame 27 to make the up and down movement of the mobile frame 10 more stable. A one-way threaded rod 2 11 is set inside the mobile frame 10 to adjust the position of the one-way threaded rod 2 11 when the one-way threaded rod 2 11 rotates. A sliding frame 12 is set on the left side of the one-way threaded rod 2 11, and a sliding frame 2 13 is set on the right side to support the one-way threaded rod 2 11. A connecting rod 2 14 is set between the sliding frame 12 and the sliding frame 2 13 to stabilize the movement of the one-way threaded rod 2 11. A connecting frame 16 is fixed on the top of the sliding frame 2 13 to connect to the fixed frame 17, and the fixed frame 17 is used to support the syringe 26.

[0034] Reference Figure 3 - Figure 4 The control component includes a reducer 20, which is fixedly connected to the top of the fixed frame 17. A motor 21 is fixedly connected to the top of the reducer 20. A one-way threaded rod 18 is fixedly connected to the output end of the motor 21. The outer periphery of the one-way threaded rod 18 is threadedly connected to a sliding block 19. The motor 21 is electrically connected to the controller 29. The sliding block 19 is slidably connected to the inside of the fixed frame 17, and the sliding block 19 abuts against both ends of the piston rod 27.

[0035] Specifically, the reducer 20 is set on the fixed frame 17, and the motor 21 is installed on the top of the reducer 20, which is used to start the motor 21 to drive the one-way threaded rod three 18 to rotate, and the reducer 20 can enable the motor 21 to control the one-way threaded rod three 18 more stably. A sliding block 19 is set on the outer periphery of the one-way threaded rod three 18, and the sliding block 19 is used to control the piston rod 27 of the syringe 26, thereby accurately controlling the injection volume and injection speed of the syringe 26, and the motor 21 is connected to the controller 29, so that the controller 29 can control the motor 21 and thus control the injection volume and injection speed of the syringe 26.

[0036] Reference Figure 4The clamping assembly includes two bidirectional threaded rods 22, which are rotatably connected to the inside of the fixed frame 17. The outer circumference of the two bidirectional threaded rods 22 is threadedly connected to two moving blocks 23. The front ends of the two moving blocks 23 are fixedly connected to clamping hands 24. The two clamping hands 24 are abutted against syringes 26 on the opposite sides. The top of the syringe 26 is slidably connected to a piston rod 27, and the bottom of the syringe 26 is fixedly connected to a guide tube 28. Multiple moving blocks 23 are slidably connected to the inside of the fixed frame 17, and the left sides of the two bidirectional threaded rods 22 are fixedly connected to a turning hand 25.

[0037] Specifically, the bidirectional threaded rod 22 is set on the fixed frame 17, and is used to drive the two moving blocks 23 to rotate in opposite directions by rotating the bidirectional threaded rod 22. A clamping hand 24 is set at the front end of the moving block 23, and is used to fix the syringe 26 through the clamping hand 24. A piston rod 27 is set at the top of the syringe 26, and is used to press the piston rod 27 to make the syringe 26 work. A guide tube 28 is set at the bottom of the syringe 26, and is used to inject through the injection needle. A turning handle 25 is set on the left side of the bidirectional threaded rod 22 for the operator to better rotate the bidirectional threaded rod 22.

[0038] Working principle: When the position and angle of the syringe 26 need to be adjusted, turning the handle 4 can drive the support wheel 3 to rotate, thereby adjusting the angle of the syringe 26, turning the handle 1 9 drives the one-way threaded rod 1 6 to rotate, thereby driving the movable frame 10 to move up and down, so that the syringe 26 moves up and down, turning the handle 2 15 drives the one-way threaded rod 2 11 to rotate, thereby adjusting the horizontal position of the syringe 26, and by adjusting the above three positions, the syringe 26 can be more accurately aimed at the target brain area.

[0039] When it is necessary to control the syringe 26 to inject the target brain area, the controller 29 controls the motor 21 to drive the one-way threaded rod three 18 to rotate, and the reducer 20 is used to enable the motor 21 to more accurately control the rotation of the one-way threaded rod three 18. When the one-way threaded rod three 18 rotates, it can drive the sliding block 19 to move, thereby driving the piston rod 27 of the syringe 26 to move through the sliding block 19, so as to more accurately control the injection volume and injection speed. When the syringe 26 needs to be replaced, the turning handle three 25 can be rotated to drive the two-way threaded rod 22 to rotate, so that the clamping hand 24 no longer fixes the syringe 26, and the syringe 26 can be removed. When installing the syringe 26, the syringe 26 is placed between the clamping hands 24, and then the turning handle three 25 is rotated to drive the two-way threaded rod 22 to rotate, so that the clamping hand 24 fixes the syringe 26, thereby successfully installing it and improving the efficiency of replacing the syringe 26.

[0040] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent replacements for some of the technical features therein. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A microinjection pump for stereotactic brain injection, comprising a base (1) and a controller (29), characterized in that: The top of the base (1) is rotatably connected to a rotating seat (2), the top of the rotating seat (2) is fixedly connected to a supporting wheel (3), the top of the supporting wheel (3) is fixedly connected to a supporting frame 1 (5), the top of the supporting frame 1 (5) is rotatably connected to a one-way threaded rod 1 (6), the top of the one-way threaded rod 1 (6) is rotatably connected to a supporting frame 2 (7), the outer periphery of the one-way threaded rod 1 (6) is threadedly connected to a moving frame (10), the inner part of the moving frame (10) is threadedly connected to a one-way threaded rod 2 (11), the left side of the one-way threaded rod 2 (11) is rotatably connected to a sliding frame 1 (12), the right side of the sliding frame 1 (12) is rotatably connected to a sliding frame 2 (13), the front end of the sliding frame 2 (13) is fixedly connected to a connecting frame (16), the right side of the connecting frame (16) is fixedly connected to a fixed frame (17), the top of the fixed frame (17) is provided with a control component, and the inside of the fixed frame (17) is provided with a clamping component.

2. A microinjection pump for stereotactic brain injection according to claim 1, characterized in that: The control component includes a reducer (20), the reducer (20) is fixedly connected to the top of the fixed frame (17), the top of the reducer (20) is fixedly connected to a motor (21), the output end of the motor (21) is fixedly connected to a one-way threaded rod (18), the outer periphery of the one-way threaded rod (18) is threadedly connected to a sliding block (19), and the motor (21) is electrically connected to the controller (29).

3. A microinjection pump for stereotactic brain injection according to claim 2, characterized in that: The clamping assembly includes two bidirectional threaded rods (22), both of which are rotatably connected to the interior of the fixing frame (17), and the outer peripheries of the two bidirectional threaded rods (22) are threadedly connected to two moving blocks (23), and the front ends of the two moving blocks (23) are fixedly connected to clamping hands (24), and the two clamping hands (24) are abutted against syringes (26) on opposite sides, and the top of the syringe (26) is slidably connected to a piston rod (27), and the bottom of the syringe (26) is fixedly connected to a guide tube (28).

4. The microinjection pump for stereotactic brain injection according to claim 1, characterized in that: The support frame 1 (5) and the support frame 2 (7) are fixedly connected to two connecting rods 1 (8) on the side facing each other, and the movable frame (10) is slidably connected to the outer periphery of the two connecting rods 1 (8). The sliding frame 1 (12) and the sliding frame 2 (13) are fixedly connected to two connecting rods 2 (14) on the side facing each other, and the movable frame (10) is slidably connected to the outer periphery of the two connecting rods 2 (14).

5. The microinjection pump for stereotactic brain injection according to claim 1, characterized in that: The left side of the support wheel (3) is fixedly connected to a turning handle (4), the top of the one-way threaded rod (6) is fixedly connected to a turning handle (9), and the left side of the one-way threaded rod (11) is fixedly connected to a turning handle (15).

6. A microinjection pump for stereotactic brain injection according to claim 3, characterized in that: The sliding block (19) is slidably connected to the interior of the fixing frame (17), and the sliding block (19) abuts against both ends of the piston rod (27).

7. A microinjection pump for stereotactic brain injection according to claim 3, characterized in that: The plurality of moving blocks (23) are all slidably connected to the interior of the fixed frame (17), and the left sides of the two bidirectional threaded rods (22) are both fixedly connected to a third hand (25).

8. The microinjection pump for stereotactic brain injection according to claim 1, characterized in that: The front end of the controller (29) is fixedly connected to a display.

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