Adult simulation load device for online calibration of extracorporeal membrane oxygenation system

Abstract

The utility model relates to an adult simulation load device for online calibration of an extracorporeal membrane oxygenation system. The system comprises a left ventricular artery system simulation box, a right atrial vein system simulation box, a resistance device, a V-A ECMO treatment mode artery perfusion cannula, a V-V ECMO treatment mode vein perfusion cannula, a vein drainage cannula, a bottom plate, a right atrial vein system simulation box hydraulic monitoring sensor, a left ventricular artery system simulation box hydraulic monitoring sensor and a manual pressure release valve. And a ball valve pressurizing device and a vertical partition plate. The left ventricular artery system simulation box, the resistance device and the right atrial vein system simulation box are sequentially connected through pipelines. The device is simple in structure, convenient and practical to operate and capable of accurately simulating the blood volume of a patient, the pressure difference between a venous system and an arterial system and the resistance of a blood circulation system when an adult patient adopts a V-A ECMO treatment mode and a V-V ECMO treatment mode respectively, and has practical value; calibration data has clinical guiding significance, the measurement accuracy of key parameters of equipment is effectively guaranteed, and clinical risks are reduced.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical measurement field especially is involved in a kind of adult simulation load device for extracorporeal membrane oxygenation system online calibration. BACKGROUND

[0002] Extracorporeal membrane oxygenation system belongs to extracorporeal life support system, and its basic working principle is to drain the venous blood of patient to extracorporeal, and after oxygenation and carbon dioxide removal, it is back to the body of patient, assumes gas exchange and / or blood circulation function, and can provide full or partial cardiopulmonary support for patients with acute respiratory and / or circulatory failure.According to different treatment modes and purposes, the clinical use extracorporeal membrane oxygenation system system to treat patients mainly has two treatment modes of venous to venous (veno-venous ECMO, W-ECMO) and venous to arterial (veno-arterial ECMO, VA-ECMO), the former only has respiratory auxiliary function, and the latter has circulation and respiratory auxiliary function simultaneously.

[0003] With the large application of extracorporeal membrane oxygenation system in clinic, the accuracy of its key parameters cannot be ignored.According to the evaluation of international authoritative organization, extracorporeal membrane oxygenation system is one of the medical devices with the highest clinical risk in hospital, so the performance of extracorporeal membrane oxygenation system is directly related to the health and safety of the majority of patients.For the extracorporeal membrane oxygenation system used in medical institutions, formulating scientific and reasonable quality control plan and carrying out quality control regularly are effective methods to ensure its clinical effectiveness and reduce medical risk.Periodic measurement and calibration are important work of preventive maintenance in quality control, and are also the fundamental means to ensure the accuracy of the value of related medical equipment.

[0004] For the need of clinical application, the extracorporeal membrane oxygenation system is a common equipment for clinical treatment and emergency rescue of various heart-lung failure patients, which has the characteristics of long-time continuous operation once started. It is urgent to develop online measurement calibration and quality control for the extracorporeal membrane oxygenation system in clinical use stage, so as to effectively guarantee the quality of clinical use. In the clinical use stage, when the V-A ECMO treatment mode is adopted, the drainage tube and the perfusion tube in the circulation pipeline of the extracorporeal membrane oxygenation system are connected with the venous system blood vessels and the arterial system blood vessels of the patient respectively; when the V-V ECMO treatment mode is adopted, the drainage tube and the perfusion tube in the circulation pipeline of the extracorporeal membrane oxygenation system are connected with the venous system blood vessels at different positions respectively. In this state, the blood volume of the patient's circulation system, the pressure difference between the venous system and the arterial system, and the geometric size of the blood vessel cannula used for treatment will all generate resistance to the blood flow in the extracorporeal circulation pipeline of the extracorporeal membrane oxygenation system, thereby affecting the blood flow state in the extracorporeal circulation pipeline of the extracorporeal membrane oxygenation system. At present, when calibrating the extracorporeal membrane oxygenation system, there is a lack of a simulation load device which can effectively simulate the hydraulic resistance generated by the blood vessel cannula implanted in the patient for drainage and perfusion and the patient's blood circulation system in the use stage of the extracorporeal membrane oxygenation system. At present, in order to ensure the safety of the patient and avoid the influence of individual differences between patients on the calibration results, the method of directly short-circuiting the drainage tube port and the perfusion tube port of the circulation pipeline of the extracorporeal membrane oxygenation system to be calibrated is adopted. In this state, the extracorporeal membrane oxygenation system is not connected with the patient as a load, and the liquid flow state in the circulation pipeline is obviously different from that when the extracorporeal membrane oxygenation system is used for clinical treatment of the patient, so the calibration data lacks clinical guiding significance. It is urgent to develop a simulation load device for online calibration of the extracorporeal membrane oxygenation system, which can simulate the hydraulic resistance generated by the blood vessel cannula implanted in the patient for drainage and perfusion and the patient's blood circulation system when the patient adopts V-A ECMO and V-V ECMO treatment modes respectively, to solve the above problems.

[0005] In view of the defects of the existing technology, the designer has continuously researched and designed, and finally created the practical new type. SUMMARY

[0006] The utility model discloses a purpose at, overcome the defect of existing technology, and provide a kind of adult simulation load device for online calibration of extracorporeal membrane oxygenation system of novel structure, the technical problem to be solved is that when it can be used to simulate the hydraulic resistance generated by patient blood circulation system, vascular cannula implanted in patient body and so on when V-A ECMO, V-V ECMO two kinds of treatment modes are adopted to adult patient respectively, for calibration extracorporeal membrane oxygenation system, replace patient and be connected with calibrated extracorporeal membrane oxygenation system circulation pipeline, make liquid flow state in circulation pipeline close to actual state in clinical treatment, ensure that calibration data is more with clinical guiding significance, to be more suitable for practical.

[0007] The utility model discloses a purpose and solve its technical problem is to use following's technical scheme to realize.A kind of adult simulation load device for online calibration of extracorporeal membrane oxygenation system according to the utility model proposes, it mainly includes: left ventricle arterial system simulation box, right atrium venous system simulation box, resistance device, V-A ECMO treatment mode arterial perfusion cannula, V-V ECMO treatment mode venous perfusion cannula, venous drainage cannula, bottom plate, right atrium venous system simulation box hydraulic monitoring sensor, left ventricle arterial system simulation box hydraulic monitoring sensor, manual pressure relief valve, balloon pressurizing device and vertical partition, wherein, left ventricle arterial system simulation box, resistance device, right atrium venous system simulation box are sequentially connected by pipeline, left ventricle arterial system simulation box hydraulic monitoring sensor is installed at the side of left ventricle arterial system simulation box and V-A ECMO treatment mode arterial perfusion cannula at same height, right atrium venous system simulation box hydraulic monitoring sensor is installed at the side of right atrium venous system simulation box and V-V ECMO treatment mode venous perfusion cannula and venous drainage cannula at same height, to ensure that measurement pressure is accurate, hydraulic monitoring sensor interface for connecting liquid left ventricle arterial system simulation box hydraulic monitoring sensor and right atrium venous system simulation box hydraulic monitoring sensor are designed as not directly opposite fluid inlet direction, V-V ECMO treatment mode venous perfusion cannula and venous drainage cannula are side by side installed in the lower part of right atrium venous system simulation box, V-A ECMO treatment mode arterial perfusion cannula is installed in the lower part of left ventricle arterial system simulation box, left ventricle arterial system simulation box bottom and right atrium venous system simulation box bottom are installed on bottom plate, the outer end of V-A ECMO treatment mode arterial perfusion cannula, the outer end of V-V ECMO treatment mode venous perfusion cannula and the outer end of venous drainage cannula are installed on bottom plate, the blood volume of load simulated by connecting pipe between left ventricle arterial system simulation box, right atrium venous system simulation box and each part, namely total volume, is designed as 4000ml, wherein the volume of connecting pipe between each part is about 50ml, and the total volume of left ventricle arterial system simulation box and right atrium venous system simulation box is about 3950ml.

[0008] Further, the left ventricular arterial system simulation box is a cylindrical sealed box structure with a diameter of 110 mm and a height of 250 mm, the pressure in the left ventricular arterial system simulation box reaches 90 mmHg, a balloon pressurizing device interface and a manual pressure relief valve interface are arranged on the center axis of the upper end surface of the left ventricular arterial system simulation box, a hydraulic monitoring sensor interface located on the same side of the balloon pressurizing device interface is arranged at the bottom of the left ventricular arterial system simulation box, a standby interface located on the same side of the manual pressure relief valve interface is arranged at the bottom of the left ventricular arterial system simulation box, a resistance device interface is arranged at the bottom of the left ventricular arterial system simulation box and is arranged in axial symmetry with the hydraulic monitoring sensor interface, a V-A ECMO treatment mode arterial perfusion cannula interface is arranged at the bottom of the left ventricular arterial system simulation box and is arranged in axial symmetry with the standby interface, wherein the balloon pressurizing device interface arranged on the upper end surface of the left ventricular arterial system simulation box is connected with the balloon pressurizing device, the manual pressure relief valve interface arranged on the upper end surface of the left ventricular arterial system simulation box is connected with the manual pressure relief valve, the hydraulic monitoring sensor interface is connected with the hydraulic monitoring sensor of the left ventricular arterial system simulation box, the resistance device interface is connected with the resistance device, and the V-A ECMO treatment mode arterial perfusion cannula interface is connected with the V-A ECMO treatment mode arterial perfusion cannula.

[0009] Further, the pressure in the right atrial venous system simulation box is less than 10 mmHg, a rectangular box body structure directly connected with the atmosphere is adopted, the length and width are each 120 mm, and the height is 245 mm, a vertical partition plate with a height lower than the liquid level plane is arranged in the middle of the right atrial venous system simulation box, the vertical partition plate has a height of 140 mm, a resistance device interface and a hydraulic monitoring sensor interface are arranged in axial symmetry on the lower parts of the two side plates of the right atrial venous system simulation box, a venous drainage cannula interface and a V-V ECMO treatment mode venous perfusion cannula interface are arranged on the lower part of the other side plate of the right atrial venous system simulation box, wherein the resistance device interface is connected with the resistance device, the hydraulic monitoring sensor interface is connected with the hydraulic monitoring sensor of the right atrial venous system simulation box, the venous drainage cannula interface is connected with the venous drainage cannula, and the V-V ECMO treatment mode venous perfusion cannula interface is connected with the V-V ECMO treatment mode venous perfusion cannula.

[0010] Compared with the prior art, the utility model has obvious advantages and beneficial effects.

[0011] 1. The utility model discloses a reasonable design, simple structure, convenient operation, economic and suitable, can accurately simulate the blood volume of patient, the pressure difference between venous system and arterial system and the blood circulation system resistance of adult patient respectively under two kinds of treatment modes of V-A ECMO, V-V ECMO, has obvious practical value;

[0012] 2. The load as a simulation patient is used for online calibration of an extracorporeal membrane oxygenation system, calibration data is more clinically instructive, can effectively guarantee the measurement accuracy of key parameters of the equipment, reduce the clinical risk, and has obvious social significance.

[0013] The above description is only a summary of the technical scheme of the present application. In order to more clearly understand the technical means of the present application, and can be implemented in accordance with the content of the specification, the following is a detailed description of the preferred embodiments of the present application with reference to the accompanying drawings. BRIEF DESCRIPTION OF DRAWINGS

[0014] Figure 1 It is a structural schematic diagram of the present application.

[0015] Figure 2 It is a structural schematic diagram of the left ventricular arterial system simulation box of the present application

[0016] Figure 3 It is a structural schematic diagram of the right atrial venous system simulation box of the present application.

[0017] Among them:

[0018] 1: left ventricular arterial system simulation box

[0019] 1-1: balloon pressurizing device interface 1-2: manual pressure relief valve interface

[0020] 1-3: hydraulic monitoring sensor interface 1-4: spare interface

[0021] 1-5: resistance device interface 1-6: V-A ECMO treatment mode arterial perfusion cannula interface 2: right atrial venous system simulation box

[0022] 2-1: resistance device interface 2-2: hydraulic monitoring sensor interface

[0023] 2-3: venous drainage cannula interface 2-4: V-V ECMO treatment mode venous perfusion cannula interface 3: resistance device 4: V-A ECMO treatment mode arterial perfusion cannula

[0024] 5: V-V ECMO treatment mode venous perfusion cannula 6: venous drainage cannula

[0025] 7: bottom plate 8: right atrial venous system simulation box hydraulic monitoring sensor 9: left ventricular arterial system simulation box hydraulic monitoring sensor

[0026] 10: manual pressure relief valve 11: balloon pressurizing device , 12: vertical partition DETAILED DESCRIPTION

[0027] In order to further illustrate the technical means and effects taken by the utility model to achieve the predetermined invention purpose and the functions, the specific implementation, structure, features and effects of the adult simulation load device for online calibration of an extracorporeal membrane oxygenation system according to the utility model will be described in detail below in combination with the drawings and preferred embodiments.

[0028] Please refer to Figure 1 The adult simulation load device for online calibration of an extracorporeal membrane oxygenation system according to the preferred embodiment of the utility model mainly comprises: a left ventricular arterial system simulation box 1, a right atrial venous system simulation box 2, a resistance device 3, a V-A ECMO treatment mode arterial perfusion cannula 4, a V-V ECMO treatment mode venous perfusion cannula 5, a venous drainage cannula 6, a bottom plate 7, a right atrial venous system simulation box hydraulic pressure monitoring sensor 8, a left ventricular arterial system simulation box hydraulic pressure monitoring sensor 9, a manual pressure relief valve 10, a balloon pressurizing device 11 and a vertical partition plate 12, wherein the left ventricular arterial system simulation box 1, the resistance device 3 and the right atrial venous system simulation box 2 are sequentially connected through pipelines, the left ventricular arterial system simulation box hydraulic pressure monitoring sensor 9 is installed on the side surface of the left ventricular arterial system simulation box 1 at the same height as the V-A ECMO treatment mode arterial perfusion cannula 4, the right atrial venous system simulation box hydraulic pressure monitoring sensor 8 is installed on the side surface of the right atrial venous system simulation box 2 at the same height as the V-V ECMO treatment mode venous perfusion cannula 5 and the venous drainage cannula 6, in order to avoid the influence of circulating liquid flow on pressure monitoring data, the hydraulic pressure monitoring sensor interface 2-2 for connecting the right atrial venous system simulation box hydraulic pressure monitoring sensor 8 and the hydraulic pressure monitoring sensor interface 1-3 for connecting the left ventricular arterial system simulation box hydraulic pressure monitoring sensor 9 are both designed not to face the fluid inlet direction.

[0029] The lower part of the right atrial venous system simulation box 2 is provided with the V-V ECMO treatment mode venous perfusion cannula 5 and the venous drainage cannula 6 in parallel, the lower part of the left ventricular arterial system simulation box 1 is provided with the V-A ECMO treatment mode arterial perfusion cannula 4, the bottom part of the left ventricular arterial system simulation box 1 and the bottom part of the right atrial venous system simulation box 2 are installed on the bottom plate 7, the outer end part of the V-A ECMO treatment mode arterial perfusion cannula 4, the outer end part of the V-V ECMO treatment mode venous perfusion cannula 5 and the outer end part of the venous drainage cannula 6 are installed on the bottom plate 7, the blood volume of the load simulated by the connecting pipelines between the left ventricular arterial system simulation box 1, the right atrial venous system simulation box 2 and each part, i.e. the total volume, is designed to be 4000 mL, wherein the volume of the connecting pipelines between each part is about 50 mL, and the total volume of the left ventricular arterial system simulation box 1 and the right atrial venous system simulation box 2 is about 3950 mL.

[0030] As Figure 2As shown, the preferred second embodiment of the present invention is an adult simulation load device for online calibration of an extracorporeal membrane oxygenation system, wherein the pressure in the left ventricular artery system simulation box 1 must reach 90 mmHg, while meeting the volume requirements and saving space to the greatest extent. In addition, a certain amount of gas space is reserved on the left ventricular artery system simulation box structure to ensure the stability of the cylindrical sealed box. Therefore, the left ventricular artery system simulation box 1 is a cylindrical sealed box structure with a diameter of 110 mm and a height of 250 mm. A balloon pressurizing device interface 1-1 and a manual pressure relief valve interface 1-2 are respectively provided on both sides of the central axis of the upper end face of the left ventricular artery system simulation box 1. The hydraulic monitoring sensor interface 1-3 located on the same side of the balloon pressurizing device interface 1-1 is provided at the bottom of the left ventricular artery system simulation box 1: the spare interface 1-4 located on the same side of the manual pressure relief valve interface 1-2 is provided at the bottom of the left ventricular artery system simulation box 1: the resistance device interface 1-5 is provided at the bottom of the left ventricular artery system simulation box 1 and is axially symmetrical with the hydraulic monitoring sensor interface 1-3. ECMO therapy mode arterial perfusion cannula interface 1-6 is disposed at the bottom of the left ventricular artery system simulation box 1 and is axially symmetrically arranged with the backup interface 1-4. The balloon pressurizing device interface 1-1 disposed on the upper end surface of the left ventricular artery system simulation box 1 is connected to the balloon pressurizing device 11. The manual pressure relief valve interface 1-2 disposed on the upper end surface of the left ventricular artery system simulation box 1 is connected to the manual pressure relief valve 10. The hydraulic monitoring sensor interface 1-3 is connected to the left ventricular artery system simulation box hydraulic monitoring sensor 9. The resistance device interface 1-5 is connected to the resistance device 3. The VA ECMO therapy mode arterial perfusion cannula interface 1-6 is connected to the VA ECMO therapy mode arterial perfusion cannula 4. Other structures are the same as those in Example 1.

[0031] like Figure 3 As shown, a third preferred embodiment of the present invention is an adult simulated load device for online calibration of an extracorporeal membrane oxygenation system. The pressure within the right atrial venous system simulation box 2 is less than 10 mmHg. Therefore, a rectangular box structure directly connected to the atmosphere is employed, with a length and width of 120 mm and a height of 245 mm. The connecting pipes between the various sections have a volume of approximately 50 mL. When simulating intubation in a venovenous extracorporeal membrane oxygenation (ECMO) treatment mode, fluid is exchanged within the right atrial venous system simulation box 2. Therefore, a vertical baffle 12, 140 mm in height, is positioned in the center of the box, below the liquid level. This baffle 12 serves to extend the flow distance of the blocked fluid and reduce the interaction between the inlet and outlet of the circulating fluid. Furthermore, the baffle 12 allows bubbles in the circulating fluid to float upward, thus venting the fluid.

[0032] The resistance device interface 2-1 and the hydraulic monitoring sensor interface 2-2 are respectively arranged in the lower part of the two side plates of the right atrial venous system simulation box 2 in axial symmetry, the venous drainage cannula interface 2-3 and the V-V ECMO treatment mode venous perfusion cannula interface 2-4 are arranged in the lower part of the other side plate of the right atrial venous system simulation box 2, wherein the resistance device interface 2-1 is connected with the resistance device 3, the hydraulic monitoring sensor interface 2-2 is connected with the right atrial venous system simulation box hydraulic monitoring sensor 8, the venous drainage cannula interface 2-3 is connected with the venous drainage cannula 6, the V-V ECMO treatment mode venous perfusion cannula interface 2-4 is connected with the V-V ECMO treatment mode venous perfusion cannula 5, and other structures are the same as those in the embodiment 2.

[0033] The test process using the utility model is explained as follows:

[0034] 1. The process of using the utility model as a V-A ECMO treatment mode load calibration extracorporeal membrane oxygenation system is:

[0035] The utility model discloses a stable placement, close V-V ECMO treatment mode venous perfusion cannula 5 port valve, close V-A ECMO treatment mode arterial perfusion cannula 4 port valve, close venous drainage cannula 6 port valve. 4000ml calibration medium liquid is filled from right atrium venous system simulation box 2, after left ventricle arterial system simulation box 1 and right atrium venous system simulation box 2 liquid steady, close hand -operated pressure relief valve 10, adjust the valve opening of resistance device 3 to preset value, through balloon pressurizing device 11 adjust left ventricle arterial system simulation box 1 internal pressure until left ventricle arterial system simulation box hydraulic pressure monitoring sensor 9 pressure monitoring value shows 90mmHg, right atrium venous system simulation box hydraulic pressure monitoring sensor 8 pressure monitoring value shows 9mmHg. The drainage pipe port in the calibrated extracorporeal membrane oxygenation system circulation pipeline is communicated with the venous drainage cannula 6 port of the utility model. The perfusion pipe port in the calibrated extracorporeal membrane oxygenation system circulation pipeline is communicated with the V-A ECMO treatment mode arterial perfusion cannula 4 port of the utility model. Open V-A ECMO treatment mode arterial perfusion cannula 4 port valve, open venous drainage cannula 6 port valve, the utility model replaces the patient as load and connects with the calibrated extracorporeal membrane oxygenation system circulation pipeline, and left ventricle arterial system simulation box hydraulic pressure monitoring sensor 9 pressure monitoring value and right atrium venous system simulation box hydraulic pressure monitoring sensor 8 pressure monitoring value are observed again, if left ventricle arterial system simulation box hydraulic pressure monitoring sensor 9 pressure monitoring value is lower than 90mmHg, through balloon pressurizing device 11 adjust left ventricle arterial system simulation box 1 internal pressure until left ventricle arterial system simulation box hydraulic pressure monitoring sensor 9 pressure monitoring value shows 90mmHg, adjust the valve opening of resistance device 3 simultaneously until right atrium venous system simulation box hydraulic pressure monitoring sensor 8 pressure monitoring value shows 9mmHg, if left ventricle arterial system simulation box hydraulic pressure monitoring sensor 9 pressure monitoring value is higher than 90mmHg, through hand -operated pressure relief valve 10, discharge part gas in left ventricle arterial system simulation box 1 until left ventricle arterial system simulation box hydraulic pressure monitoring sensor 9 pressure monitoring value shows 90mmHg, the liquid flow state in the calibrated extracorporeal membrane oxygenation system circulation pipeline is similar to the actual connection patient to carry out V-A ECMO treatment mode, can carry out online calibration to the calibrated extracorporeal membrane oxygenation under the state.

[0036] 2, use the utility model as V-V ECMO treatment mode load calibration extracorporeal membrane oxygenation system process is:

[0037] Put the analog load device flat, close the V-V ECMO treatment mode venous perfusion cannula 5 port valve, close the V-A ECMO treatment mode arterial perfusion cannula 5 port valve, close the venous drainage cannula 6 port valve. 4000mL calibration medium liquid is filled from the right atrial venous system simulation tank 2, 4000mL calibration medium liquid is filled from the right atrial venous system simulation tank 2, after the left ventricular arterial system simulation tank 1 and the right atrial venous system simulation tank 2 are filled with liquid, the manual pressure relief valve 10 is closed, the valve opening degree in the resistance device 3 is adjusted to the preset value, the left ventricular arterial system simulation tank 1 internal pressure is adjusted through the balloon pressure device 11 until the left ventricular arterial system simulation tank hydraulic pressure monitoring sensor 9 pressure monitoring value displays 90mmHg, the right atrial venous system simulation tank hydraulic pressure monitoring sensor 8 pressure monitoring value displays 9mmHg. The drainage pipe port in the calibrated extracorporeal membrane oxygenation system circulation pipeline is communicated with the venous drainage cannula 6 port of the utility model. The perfusion pipe port in the calibrated extracorporeal membrane oxygenation system circulation pipeline is communicated with the V-V ECMO treatment mode venous perfusion cannula 5 port of the utility model. The V-V ECMO treatment mode arterial perfusion cannula 5 port valve is opened, the venous drainage cannula 6 port valve is opened, the utility model replaces the patient as a load and is connected with the calibrated extracorporeal membrane oxygenation system circulation pipeline, the left ventricular arterial system simulation tank hydraulic pressure monitoring sensor 9 pressure monitoring value and the right atrial venous system simulation tank hydraulic pressure monitoring sensor 8 pressure monitoring value are observed again, if the left ventricular arterial system simulation tank hydraulic pressure monitoring sensor 9 pressure monitoring value is lower than 90mmHg, the left ventricular arterial system simulation tank 1 internal pressure is adjusted through the balloon pressure device 11 until the left ventricular arterial system simulation tank hydraulic pressure monitoring sensor 9 pressure monitoring value displays 90mmHg, and the valve opening degree in the resistance device 3 is adjusted until the right atrial venous system simulation tank hydraulic pressure monitoring sensor 8 pressure monitoring value displays 9mmHg, if the left ventricular arterial system simulation tank hydraulic pressure monitoring sensor 9 pressure monitoring value is higher than 90mmHg, part of gas in the left ventricular arterial system simulation tank 1 is discharged through the manual pressure relief valve 10 until the left ventricular arterial system simulation tank hydraulic pressure monitoring sensor 9 pressure monitoring value displays 90mmHg, at this time, the liquid flow state in the calibrated extracorporeal membrane oxygenation system circulation pipeline is similar to the actual connection patient developing V-V ECMO treatment mode, and the calibrated extracorporeal membrane oxygenation system can be calibrated online under the state.

[0038] When designing the utility model, in order to determine various water conservancy parameters, it is necessary to clearly understand the patient signs of load simulation, including body weight, blood volume and arterial system pressure difference, ECMO treatment mode includes cannula mode, cannula site and the like, and the geometric size of the vascular cannula.

[0039] Patient sign determination: blood volume is an important parameter designed by the utility model, and the blood volume and hemoglobin content estimation table of patients of different ages is given according to the 2017 edition of 'Guidelines for Perioperative Fluid and Blood Transfusion Management in Children' issued by the Chinese Medical Association Anesthesiology Branch. After the clinical patient research of medical institutions and the suggestion of relevant doctors, it is determined that the utility model simulates the weight of 60kg adult patients. According to the data given in table 1, the load blood volume is calculated to be approximately in the range of 3900mL-4200mL, and finally it is determined that the blood volume simulated by the left ventricular arterial system simulation box 1, the right atrial venous system simulation box 2 and the connecting pipe between each part of the utility model, that is, the total volume is designed to be 4000mL, wherein the volume of the connecting pipe between each part is about 50mL, and the total volume of the left ventricular arterial system simulation box 1 and the right atrial venous system simulation box 2 is about 3950mL.

[0040] Table 1 blood volume and hemoglobin content estimation table of patients of different ages

[0041] Age Blood volume (mL / kg) Hemoglobin (g / L) Premature infants 90～100 130～200 Term newborns 80～90 150～230 < 1 year 75～80 110～180 1-6 years 70～75 120～140 > 6 years and adults 65～70 120～160

[0042] According to the blood pressure range of the drainage and perfusion site of patients under different treatment modes shown in table 2, it is determined that when the utility model simulates the V-A ECMO mode, the hydraulic pressure of the V-A ECMO treatment mode arterial perfusion cannula interface 1-6 position at the bottom of the left ventricular arterial system simulation box 1 is 90mmHg, and the hydraulic pressure of the venous drainage cannula interface 2-3 position at the bottom of the right atrial venous system simulation box 2 is 9mmHg; when the utility model simulates the V-V ECMO mode, the hydraulic pressure of the V-V ECMO treatment mode venous perfusion cannula interface 2-4 position at the bottom of the right atrial venous system simulation box 2 is 9mmHg, and the hydraulic pressure of the venous drainage cannula interface 2-3 position is 9mmHg.

[0043] Table 2 blood pressure comparison table of drainage and perfusion sites of different treatment modes

[0044]

[0045] In the utility model, the venous drainage cannula 6 is designed to have a length of 55cm and an inner diameter of 7mm; the V-V ECMO treatment mode venous perfusion cannula 5 is designed to have a length of 23cm and an inner diameter of 5.7mm; and the V-A ECMO treatment mode arterial perfusion cannula 4 is designed to have a length of 23cm and an inner diameter of 5.7mm.

[0046] The above merely describes preferred embodiments of the present application and is not intended to limit the present application in any form. Although the present application has been disclosed with preferred embodiments, it is not intended to limit the present application. Any skilled person in the art can make some changes or modifications to the disclosed technical content without departing from the technical solution of the present application, and equivalent embodiments with equivalent changes are equivalent to the embodiments. Any simple modification, equivalent change and modification of the above embodiments based on the technical essence of the present application are still within the scope of the technical solution of the present application.

Claims

1. An adult analog load device for in-line calibration of an extracorporeal membrane oxygenation system, characterized by: The main include: left ventricular arterial system simulation box (1), right atrial venous system simulation box (2), resistance device (3), V-A ECMO treatment mode arterial perfusion cannula (4), V-V ECMO treatment mode venous perfusion cannula (5), venous drainage cannula (6), bottom plate (7), right atrial venous system simulation box hydraulic monitoring sensor (8), left ventricular arterial system simulation box hydraulic monitoring sensor (9), manual pressure relief valve (10), balloon pressurizing device (11) and vertical partition (12), wherein, left ventricular arterial system simulation box (1), resistance device (3), right atrial venous system simulation box (2) are connected in sequence through pipeline, left ventricular arterial system simulation box hydraulic monitoring sensor (9) is installed on the side of left ventricular arterial system simulation box (1) and V-A ECMO treatment mode arterial perfusion cannula (4) is at the same height, right atrial venous system simulation box hydraulic monitoring sensor (8) is installed on the side of right atrial venous system simulation box (2) and V-V ECMO treatment mode venous perfusion cannula (5) and venous drainage cannula (6) are at the same height, hydraulic monitoring sensor interface (1-3) for connecting left ventricular arterial system simulation box hydraulic monitoring sensor (9) and hydraulic monitoring sensor interface (2-2) for connecting right atrial venous system simulation box hydraulic monitoring sensor (8) are all designed not to face the direction of fluid inlet, V-V ECMO treatment mode venous perfusion cannula (5) and venous drainage cannula (6) are installed side by side in the lower part of right atrial venous system simulation box (2), V-A ECMO treatment mode arterial perfusion cannula (4) is installed in the lower part of left ventricular arterial system simulation box (1), the bottom of left ventricular arterial system simulation box (1) and the bottom of right atrial venous system simulation box (2) are installed on bottom plate (7), the outer end of V-A ECMO treatment mode arterial perfusion cannula (4), the outer end of V-V ECMO treatment mode venous perfusion cannula (5) and the outer end of venous drainage cannula (6) are installed on bottom plate (7), the blood volume of the load simulated by the connecting pipeline between left ventricular arterial system simulation box (1), right atrial venous system simulation box (2) and each part, i.e. the total volume, is designed to be 4000mL, wherein the volume of the connecting pipeline between each part is about 50mL, the total volume of left ventricular arterial system simulation box (1) and right atrial venous system simulation box (2) is about 3950mL.

2. The adult analog load device for online calibration of extracorporeal membrane oxygenation system according to claim 1, characterized in that: The left ventricular arterial system simulation box (1) is a cylindrical sealed box structure with a diameter of 110 mm and a height of 250 mm. The pressure in the left ventricular arterial system simulation box (1) reaches 90 mmHg. The center axis of the upper end surface of the left ventricular arterial system simulation box (1) is provided with a balloon pressurizing device interface (1-1) and a manual pressure relief valve interface (1-2) on both sides. The hydraulic monitoring sensor interface (1-3) on the same side of the balloon pressurizing device interface (1-1) is arranged at the bottom of the left ventricular arterial system simulation box (1). The standby interface (1-4) on the same side of the manual pressure relief valve interface (1-2) is arranged at the bottom of the left ventricular arterial system simulation box (1). The resistance device interface (1-5) is arranged at the bottom of the left ventricular arterial system simulation box (1) and is arranged in axial symmetry with the hydraulic monitoring sensor interface (1-3). The V-A ECMO treatment mode arterial perfusion cannula interface (1-6) is arranged at the bottom of the left ventricular arterial system simulation box (1) and is arranged in axial symmetry with the standby interface (1-4). The balloon pressurizing device interface (1-1) arranged on the upper end surface of the left ventricular arterial system simulation box (1) is connected with the balloon pressurizing device (11). The manual pressure relief valve interface (1-2) arranged on the upper end surface of the left ventricular arterial system simulation box (1) is connected with the manual pressure relief valve (10). The hydraulic monitoring sensor interface (1-3) is connected with the left ventricular arterial system simulation box hydraulic monitoring sensor (9). The resistance device interface (1-5) is connected with the resistance device (3). The V-A ECMO treatment mode arterial perfusion cannula interface (1-6) is connected with the V-A ECMO treatment mode arterial perfusion cannula (4).

3. The adult analog load device for online calibration of extracorporeal membrane oxygenation system according to claim 1, characterized in that: The pressure in the right atrial venous system simulation box (2) is less than 10 mmHg. A rectangular box body structure is directly connected to the atmosphere. The length and width are each 120 mm, and the height is 245 mm. A vertical partition plate (12) with a height lower than the liquid level is arranged in the middle of the right atrial venous system simulation box (2). The vertical partition plate (12) has a height of 140 mm. The resistance device interface (2-1) and the hydraulic monitoring sensor interface (2-2) are arranged in axial symmetry on the lower part of the two side plates of the right atrial venous system simulation box (2). The venous drainage cannula interface (2-3) and the V-V ECMO treatment mode venous perfusion cannula interface (2-4) are arranged on the lower part of the other side plate of the right atrial venous system simulation box (2). The resistance device interface (2-1) is connected with the resistance device (3). The hydraulic monitoring sensor interface (2-2) is connected with the right atrial venous system simulation box hydraulic monitoring sensor (8). The venous drainage cannula interface (2-3) is connected with the venous drainage cannula (6). The V-V ECMO treatment mode venous perfusion cannula interface (2-4) is connected with the V-V ECMO treatment mode venous perfusion cannula (5).

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