High airtightness capsule

Abstract

To provide a high airtightness capsule capable of maintaining high airtightness of a vial bottle for a long time and being used regardless of a shape of a port part of the vial bottle.SOLUTION: A bottomed cylindrical bottle fixing instrument 10 to which a lidded vial bottle P is inserted and fixed is provided. A seal ring body 20 fitted around an outer periphery of a trunk part P1 of the vial bottle P is provided. A press-in device 30 having a fitting cylinder part 31 and a connection screw part 32 is provided. The fitting cylinder part 31 is fitted around the outer periphery of the trunk part P1 of the vial bottle P. The connection screw part 32 is formed and spread at the one end part of the fitting cylinder part 31. A press-fit opening 11 is formed in an inside of an opening part of the bottle fixing instrument 10. The bottle fixing instrument 10 and the press-in device 30 are screw-closed. The seal ring body 20 is press-fitted in the press-fit opening 11 and the bottle fixing instrument 10 and the press-in device 30 are sealed.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to a highly airtight capsule that can maintain the airtightness of a vial for a long period of time and can be used regardless of the shape of the mouth of the vial. [Background technology]

[0002] The inventors have previously proposed a cap for a highly airtight storage container that can maintain the high level of airtightness of a screw-cap bottle for a long period of time (Patent Document 1). This cap is configured such that a bottle fixer 10 that is screwed onto the threaded portion P1 of a screw-cap bottle P and a ring body 20 that is attached to the outer periphery of the screw-cap bottle P are screwed together via an O-ring 30, and the O-ring 30 seals the gap between the bottle fixer 10 and the outer periphery of the screw-cap bottle P, thereby enabling the high level of airtightness of the screw-cap bottle P to be maintained for a long period of time.

[0003] On the other hand, vials are used as reaction containers or storage containers for medicines. There are various types of vials, such as a crimp type in which a rubber stopper is inserted into the flange-shaped mouth to close it, an aluminum seal is placed around the mouth, and the cap is crimped using hand clippers to increase the sealing power of the cap, and a screw-top type in which a cap is screwed onto the mouth of the screw-top vial.

[0004] The vial cap described in Patent Document 2 is a cap for sealing a crimped type vial. This cap is equipped with a rubber stopper 1 that is inserted into the mouth to prevent vacuum leakage from gaps in the rubber stopper, a socket member 3 that is attached around the mouth, and a plug member 4 that is screwed into the socket member 3 at the top of the rubber stopper 1 and comes into contact with the rubber stopper 1.

[0005] When these vials are used as sampling containers or containers for injectable medicinal liquids, they may be used by piercing the cap with a needle or the like to extract the medicinal liquid inside or by injecting multiple medicinal liquids into the vial and mixing them together. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Patent No. 6775826 [Patent Document 2] Patent No. 5997451 Summary of the Invention [Problem to be solved by the invention]

[0007] The caps of vials are made of rubber or synthetic resin to enhance their airtightness, but the airtightness of the vial decreases when highly volatile drugs are stored in the vial or after a syringe needle or the like is inserted into the cap.

[0008] Also, there are various types of vials depending on the shape of the mouth, such as screw-top type, crimp type, simple crimp type, etc. Therefore, in order to maintain the airtightness of the vial, it is necessary to maintain high airtightness by adapting to the shape of each type of mouth, as in Patent Document 2.

[0009] Therefore, the present invention has been created to solve the above-mentioned problems, and has an object to provide a highly airtight capsule that can maintain the high airtightness of a vial for a long period of time and can be used regardless of the shape of the vial's mouth. [Means for solving the problem]

[0010] In order to achieve the above-mentioned object, the first means of the present invention comprises a bottomed, cylindrical bottle fixator 10 into which a capped vial P is inserted from the cap Q side to fix it, a seal ring 20 that is attached to the outer periphery of the body P1 of the vial P and slides along the longitudinal direction, and a press-fitting device 30 that has a fitting tubular portion 31 that fits onto the outer periphery of the body P1 of the vial P and has a connecting screw portion 32 that is expanded and formed at one end of the fitting tubular portion 31 and that is screwed into the outer periphery of the opening of the bottle fixator 10, wherein a press-fitting inlet 11 for press-fitting the seal ring 20 attached to the vial P is recessed into the inner surface of the opening side of the bottle fixator 10, and when the press-fitting device 30 is screwed onto the bottle fixator 10 to which the vial P is fixed, the seal ring 20 in contact with one end of the fitting tubular portion 31 of the press-fitting device 30 is pressed into the press-fitting inlet 11.

[0011] The bottle fixing device 10 of the second means has a contact portion 12 that contacts the upper surface of the cap Q, an outer peripheral fitting recess 13 that fits into the outer periphery of the body portion P1 of the vial P, and a screw thread 14 that screws into the connecting screw portion 32 of the press-fitting device 30.

[0012] The seal annular body 20 of the third means comprises an O-ring 21 or an O-ring 21 and a pressure-welding sleeve 22 .

[0013] The press-in device 30 of the fourth means comprises a tubular portion accommodating recess 34 extending from the other end of the mating tubular portion 31, and a press-in step portion 33 formed at one end of the mating tubular portion 31 and contacting the seal ring body 20. Effect of the Invention

[0014] As in the present invention, a press-in opening 11 is recessed into the inner surface of the opening side of the bottle fixator 10, and when the press-in device 30 is screwed onto the bottle fixator 10 with the vial P fixed thereto, the seal ring 20 in contact with one end of the mating cylindrical portion 31 is pressed into the press-in opening 11. This allows the seal ring 20 to seal the connection between the bottle fixator 10 and the press-in device 30, making it possible to maintain high airtightness of the vial for a long period of time.

[0015] Furthermore, by using a bottomed, cylindrical vial holder 10 that holds the capped vial P in place by inserting it from the cap Q side, the vial P can be used regardless of the shape of its mouth. [Brief description of the drawings]

[0016] [Figure 1] 1 is a cross-sectional view showing an embodiment of the present invention in a used state. [Diagram 2] FIG. 1 is an exploded perspective view showing an embodiment of the present invention. [Diagram 3] FIG. 2 is an exploded perspective view of the present invention and a vial with a seal ring attached. [Figure 4] FIG. 2 is an exploded perspective view of a state in which a vial is fixed to the bottle fixation device of the present invention. [Diagram 5] FIG. 4 is an enlarged cross-sectional view of a main portion of the seal annulus of the present invention in a state where it is being pressed in. [Figure 6] FIG. 2 is a perspective view of the present invention in a sealed state. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0017] The capsule of the present invention is a highly airtight capsule that maintains the airtightness of a vial bottle P, which is generally used as a highly airtight storage container, for a long period of time. This vial bottle P is available in various types, such as a screw-top type, a crimp type, and a simple crimp type, depending on the shape of the mouth.

[0018] The capsule of the present invention can be used regardless of the type of vial bottle P, and in particular, it is possible to prevent a decrease in the sealing force after the cap Q is pierced with an injection needle or the like.

[0019] The configuration of the present invention includes a bottle retainer 10, a seal ring 20, and a press fit device 30 (see FIG. 2).

[0020] The vial fixator 10 is a cylindrical member with a bottom that fixes the capped vial P in a state where it is inserted from the cap Q side (see FIG. 4). The illustrated vial fixator 10 forms a contact part 12 that contacts the upper surface of the cap Q, and an outer peripheral fitting recess 13 that fits onto the outer periphery of the body part P1 of the vial P (see FIG. 1).

[0021] Therefore, when the cap Q that has covered the vial P is pushed firmly into the vial fixator 10, the top surface of the cap Q comes into contact with the contact portion 12 of the vial fixator 10 (see FIG. 1). At this time, the contact portion 12 is formed in a recessed shape into which the outer periphery of the cap Q fits. As a result, when the cap Q that has covered the vial P is pushed into the vial fixator 10, the entire cap Q is fixed to the contact portion 12. In addition, the fixing means for the vial P is not limited to the illustrated example, and it is also possible to fix any portion from the cap Q side to the body portion P1.

[0022] Furthermore, a press-in port 11 is recessed into the inner peripheral surface of the opening side of the bottle fixer 10 (see FIG. 1). This press-in port 11 serves as a gap into which a seal ring 20 attached to the outer periphery of the body P1 of the vial P is press-fitted. Furthermore, a screw thread 14 is formed on the outer periphery of the bottle fixer 10 on the press-in port 11 side, and a press-in device 30, which will be described later, is connected.

[0023] The seal ring 20 is a ring-shaped member that is attached to the outer periphery of the body P1 of the vial P (see FIG. 3). The illustrated seal ring 20 is a combination of ring-shaped members each consisting of a plurality of O-rings 21 and pressure-welding sleeves 22 adjacent to both sides of the O-rings 21 (see FIG. 2). These O-rings 21 and pressure-welding sleeves 22 are alternately stacked to form the seal ring 20, which is attached to the body P1. The seal ring 20 is not limited to the illustrated example, and may be composed of a single or multiple O-rings 21, as long as it is press-fitted into the press-in port 11 of the vial fixing device 10 to seal it.

[0024] The illustrated seal ring 20 has two O-rings 21 with pressure sleeves 22 on either side, which are then stacked and attached to the body P1 (see FIG. 3). In this state, the cap Q of the vial P is pressed into the contact portion 12 of the vial holder 10 and fixed (see FIG. 4). Furthermore, when the press-fitting device 30 is attached to the bottom side of the vial P thus fixed and connected to the vial holder 10, the capsule of the present invention is sealed (see FIG. 6).

[0025] The press-fitting device 30 has a fitting cylinder portion 31 that fits onto the outer periphery of the body portion P1 of the vial P (see FIG. 1). Furthermore, this fitting cylinder portion 31 is a cylindrical member having a connecting screw portion 32 formed by expanding one end thereof and screwed onto the outer periphery of the opening of the vial fixing device 10.

[0026] The illustrated press-fitting device 30 is a bottomed cylindrical press-fitting device formed with a storage recess 34 for storing the bottom side of the vial P from the fitting cylindrical portion 31 (see FIG. 1). At this time, it is also possible to configure it so that the bottom of the vial P is pressed by the bottom of the storage recess 34. Furthermore, when the connecting screw portion 32 is expanded and formed at one end of the fitting cylindrical portion 31, a press-fitting step portion 33 is formed. This press-fitting step portion 33 presses the seal ring body 20 attached to the body portion P1.

[0027] That is, with the seal ring 20 attached to the vial P, the cap Q side of the vial P is inserted into the vial fixator 10 and fixed (see FIG. 4). Then, the press-fitting device 30 is attached from the body P1 side of the vial P, and the connecting screw portion 32 of this press-fitting device 30 is screwed into the threads 14 of the vial fixator 10. As the press-fitting device 30 is tightened, the seal ring 20 of the body P1 is pressed by the press-fitting step portion 33 at one end of the fitting tubular portion 31 of the press-fitting device 30, and is pressed into the press-fitting port 11 (see FIG. 5).

[0028] When the seal ring 20 is pressed into the press inlet 11 and the vial holder 10 and the press fitting device 30 are connected, the cap Q side of the vial P is sealed in the capsule of the present invention (see FIG. 1). When the bottom of the storage recess 34 is configured to press the bottom of the vial P, the adhesion between the upper surface of the cap Q and the adhesion portion 12 increases as the press fitting device 30 is tightened, and the entire vial P is sealed in the capsule of the present invention (see FIG. 6).

[0029] The following test was carried out to confirm the high sealing performance of the present invention. <Test Method> Add approximately 1.5 ml of acetone to each of the three crimped vials P (body P1 has an outer diameter of 12 mm). The capsule was sealed with the cap Q (outer diameter 11.6 mm) shown in FIG. 1 and stored at 20° C. Stored at ±5°C. The dimensions and materials of each part are as follows: The bottle fixing device 10 has an inner diameter of the press-in port 11 of 14.3 mm, an inner diameter of the contact portion 12 of 11.6 mm, and an outer periphery fitting The inner diameter of the recess 13 was 12 mm, and the thread 14 was M18-P1.5 fine. The seal ring 20 has an outer diameter of 14.2 mm, an inner diameter of 11.5 mm, and a thickness of 1.5 mm, and is made of nitrile rubber. Two bearings 21 and three pressure-welding sleeves 22 of the same shape made of synthetic resin are stacked alternately. I used the following. The press-fitting tool 30 has an inner diameter of 12 mm for the fitting cylinder portion 31, and a connecting screw portion 32 of M18-P1.5 fine thread. The total length is 7 mm. The bottle holder 10 and the press-fitting device 30 were made of ultra-high molecular weight polyethylene. Immediately after filling (day 0), 1st day, 4th day, 7th day, 14th day, 21st day, 28th day, 1st month, Mass measurements were taken at 1.5, 2, 2.5 and 3 months. At the same time, the mass of an empty sample was measured as a blank to correct for mass changes. From the results of the mass measurement of each sample, the mass was calculated based on the mass immediately after filling (day 0). The amount of change (mg) and the mass change rate (%) were calculated.

[0030]

number

[0031] In the present invention, ultra-high molecular weight polyethylene was used in the experiments, but the material is not limited to this, and it is also possible to use engineering plastics such as polyacetal and super engineering plastics. Furthermore, the configurations, shapes, materials, etc. of the bottle fixing device 10, the seal ring body 20, the press-fitting device 30, etc. of the present invention can be selected arbitrarily, and design changes are free to the extent that they do not change the gist of the present invention. [Explanation of symbols]

[0032] P Vial P1 Torso Q Cap 10 bottle fixator 11 Press inlet 12 Contact area 13 Outer periphery fitting recess 14 Threads 20 Seal ring 21 O-ring 22 Pressure sleeve 30 Pressing tool 31 Fitting cylinder part 32 Connection screw part 33 Press-fit step 34 Insertion recess

Claims

1. a sealing ring that is attached to the outer periphery of the body of the vial and slides along the longitudinal direction; and a press-fitting device that has a fitting tubular portion that fits around the outer periphery of the body of the vial and has a connecting screw portion formed at one end of the fitting tubular portion and screwed into the outer periphery of the opening of the vial fixator; a press-fitting port through which the seal ring attached to the vial P is pressed into the inner surface of the opening side of the bottle fixator, and when the press-fitting device is screwed into the bottle fixator to which the vial is fixed, the seal ring that is in contact with one end of the fitting tubular portion of the press-fitting device is pressed into the press-fitting port.

2. 2. The airtight capsule according to claim 1, wherein the vial fixing device has a contact portion that contacts the upper surface of the cap, an outer peripheral fitting recess that fits into the outer periphery of the body of the vial, and a screw thread that screws into the connecting screw portion of the press-fitting device.

3. 2. The highly airtight capsule according to claim 1, wherein said seal annular body comprises an O-ring or an O-ring and a pressure-welding sleeve.

4. 2. The airtight capsule according to claim 1, wherein the press-fitting device comprises a cylindrical portion receiving recess extending from the other end of the fitting cylindrical portion, and a press-fitting step portion formed at one end of the fitting cylindrical portion and contacting the seal annular body.

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