Transparent cross apparatus

Abstract

To reduce a wrinkle and sagging by a simple apparatus.SOLUTION: Provided are: a nanofiber sheet obtained by electrospinning a water-soluble polymer and has an X-shape, a cross shape, or a V-shape including a first linear part and a second linear part; an apparatus including the nanofiber sheet; and a method using the nanofiber sheet. In addition, provided is a nanofiber sheet containing lame.SELECTED DRAWING: Figure 3

Description

[Technical Field]

[0001] The present invention relates to a transparent appliance for solving the problems caused by looseness and sagging caused by gravity in the neck and face. [Background technology]

[0002] Currently, products used to make wrinkles and sagging skin less noticeable include "Kazuki Design Tape," a tape made of urethane film coated with an adhesive that is applied to lift sagging parts of the face, a lift-up mask that can be worn on the ears, and a sheet-type product that uses beauty serum to lift the skin and then apply it, all of which approach the epidermis of the face and neck, temporarily fixing it in a position before sagging (Patent Documents 1 to 4).

[0003] Conventional face masks are difficult to wear, requiring adjustments to the overlap of the sheet substrate to accommodate facial contours. Furthermore, simply lifting the cheeks, as in Patent Document 4, fails to achieve a beautiful, smiling facial line and fails to achieve a satisfactory lifting effect. Patent Document 5 also features an invention that addresses the above drawbacks, but it must be removed when going out or applying makeup. All of these face masks use a nonwoven fabric or thin plastic film substrate with an adhesive that connects the skin to the substrate. The combined effects of these two components lift sagging skin back to its pre-sagging position, maintaining that state for as long as possible. Patent Document 5 also describes a water-soluble electrospun sheet produced by electrospinning using a solution of a water-soluble polymer dissolved in a solvent such as water. Patent Document 6 describes a sheet that is insolubilized after spinning electrospun nanofibers to lift and improve sagging skin and wrinkles. However, conventional techniques have not been able to adequately reduce wrinkles and sagging skin using simple devices. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2006-15049 [Patent Document 2] Japanese Patent Application Laid-Open No. 2004-97785 [Patent Document 3] Patent No. 3789431 [Patent Document 4] Japanese Patent Application Laid-Open No. 2006-43255 [Patent Document 5] Japanese Patent Application Laid-Open No. 2010-259621 [Patent Document 6] Patent No. 5545989 Summary of the Invention [Problem to be solved by the invention]

[0005] An object of the present invention is to sufficiently reduce wrinkles and sagging using a simple appliance. [Means for solving the problem]

[0006] The inventors have completed the present invention by producing a nanofiber sheet containing a water-soluble polymer in a preferred shape by electrospinning. The content of the water-soluble polymer is preferably 90% by weight or more. The nanofiber sheet of the present invention can be typically applied to the face by swelling it with water and placing it on the face from a substrate.

[0007] Through trial and error, we found that the shape, position, and orientation relative to gravity of the nanofiber sheet after application is preferably X-, V-, or cross-shaped. The nanofiber sheet of the present invention may be fabricated in an X-, V-, or cross-shape, or a strip-shaped or elongated rectangular nanofiber sheet may be fabricated and applied to form an X-, V-, or cross-shape. Forming an X-, V-, or cross-shape after application provides a previously unobtainable improvement to skin problems caused by loose and sagging skin.

[0008] The present invention provides, for example, the following.

[0009] (Item 1) A nanofiber sheet obtained by electrospinning a water-soluble polymer, the nanofiber sheet including an X-shape and a cross-shape or a V-shape consisting of a first linear portion and a second linear portion.

[0010] (Item 2) Item 2. The nanofiber sheet according to item 1, wherein the angle between the first linear portion and the second linear portion is between 30 degrees and 90 degrees.

[0011] (Item 3) The nanofiber sheet has a basis weight of 0.1 g / m 2 ~100g / m 2 Item 2. The nanofiber sheet according to Item 1,

[0012] (Item 4) Item 2. The nanofiber sheet according to item 1, wherein the proportion of the water-soluble polymer in the nanofiber sheet is 90% by weight or more.

[0013] (Item 5) Item 1. The nanofiber sheet according to item 1, comprising glitter.

[0014] (Item 6) A brace comprising a nanofiber sheet in which a water-soluble polymer is electrospun onto a nonwoven fabric or plastic mesh as a nanofiber substrate, wherein the nanofiber sheet has first and second linear portions formed in an X-, cross-, or V-shape, and wherein the nanofiber sheet is fixed to a desired location.

[0015] (Item 7) Item 7. The appliance according to item 6, characterized in that the appliance is transparent and can be stacked.

[0016] (Item 8) 7. The appliance of item 6, wherein the nonwoven fabric is selected from the group consisting of spunbond, spunlace, and cotton nonwoven fabrics.

[0017] (Item 9) Item 7. The brace according to item 6, wherein the angle between the first linear portion and the second linear portion is between 30 degrees and 90 degrees.

[0018] (Item 10) The nanofiber sheet has a basis weight of 0.1 g / m 2 ~100g / m 2 Item 7. The orthosis according to item 6,

[0019] (Item 11) Item 7. The appliance according to item 6, wherein the proportion of the water-soluble polymer in the nanofiber sheet is 90% by weight or more.

[0020] (Item 12) Item 7. The appliance according to item 6, wherein the desired area is selected from the group consisting of the face, neck, and hands.

[0021] (Item 13) Item 7. The appliance according to item 6, wherein the multiple nanofiber sheets are all or partly stacked in close contact with each other during the fixing process, and are transparent even when stacked in close contact with each other.

[0022] (Item 14) Item 7. The appliance of item 6, wherein the nanofiber sheet comprises glitter.

[0023] (Item 15) A device for reducing looseness and sagging skin, comprising a first linear nanofiber sheet electrospun from a water-soluble polymer, and a second linear nanofiber sheet electrospun from a water-soluble polymer, wherein the first nanofiber sheet and the second nanofiber sheet are attached to the skin so as to form an X or V shape.

[0024] (Item 16) Item 16. The brace of item 15, wherein the angle between the first nanofiber sheet and the second nanofiber sheet is between 30 and 90 degrees.

[0025] (Item 17) The basis weight of the nanofibers in the first nanofiber sheet and the second nanofiber sheet is 0.1 g / m 2 ~100g / m 2 Item 16. The orthosis according to item 15,

[0026] (Item 18) Item 16. The appliance according to item 15, wherein the proportion of the water-soluble polymer in the first nanofiber sheet and the second nanofiber sheet is 90% by weight or more.

[0027] (Item 19) Item 16. The appliance according to item 15, wherein the skin is skin in an area selected from the group consisting of the face, neck, and hands.

[0028] (Item 20) Item 16. The appliance of item 15, wherein the nanofiber sheet comprises glitter.

[0029] (Item 21) A method for reducing looseness and sagging skin, comprising the step of applying to the skin a first linear nanofiber sheet electrospun from a water-soluble polymer and a second linear nanofiber sheet electrospun from a water-soluble polymer, wherein the applied first and second nanofiber sheets form an X-shape or a V-shape.

[0030] (Item 22) Item 22. The method of item 21, wherein the angle between the first nanofiber sheet and the second nanofiber sheet is between 30 and 90 degrees.

[0031] (Item 23) The basis weight of the nanofibers in the first nanofiber sheet and the second nanofiber sheet is 0.1 g / m2 ~100g / m 2 Item 22. The method according to Item 21, wherein

[0032] (Item 24) Item 22. The method according to item 21, wherein the proportion of the water-soluble polymer in the first nanofiber sheet and the second nanofiber sheet is 90% by weight or more.

[0033] (Item 25) Item 22. The method according to item 21, wherein the skin is skin in an area selected from the group consisting of the face, neck, and hands.

[0034] (Item 26) Item 22. The method of item 21, wherein the nanofiber sheet comprises glitter.

[0035] (Item 27) A nanofiber sheet containing lame, in which a water-soluble polymer is electrospun, wherein the proportion of the water-soluble polymer in the nanofiber sheet is 90% by weight or more.

[0036] (Item 28) The nanofiber sheet has a basis weight of 0.1 g / m 2 ~100g / m 2 Item 28. The nanofiber sheet according to Item 27,

[0037] (Item 29) Item 28. The nanofiber sheet according to item 27, wherein the glitter is selected from the group consisting of metal powder, mica powder, pearl powder, and crushed laminated plastic. [Effects of the Invention]

[0038] By applying the nanofiber sheet of the present invention to the skin, it is possible to alleviate skin problems caused by looseness and sagging skin. Furthermore, by adding glitter to the nanofiber sheet of the present invention, it is possible to achieve cosmetic effects. [Brief explanation of the drawings]

[0039] [Figure 1] Figure 1 shows the apparatus for performing electrospinning. 1 is the polymer solution or molten polymer, 2 is the high-voltage device, and 3 is the target electrode. (a) shows the application of voltage, and (b) shows the generation of the charged jet. [Figure 2] Figure 2 shows a typical shape of an X-shaped or cross-shaped nanofiber sheet. The first linear portion and the second linear portion intersect at an intersection to form an X-shaped or cross-shaped configuration. The angle between the first linear portion and the second linear portion is θ. The distance from the first end of the first linear portion to the intersection is A, and the distance from the second end to the intersection is B. [Figure 3] FIG. 3 shows a representative embodiment in which a nanofiber sheet is applied to the corners of the eyes, and a representative embodiment in which a nanofiber sheet is applied to the nasolabial folds. [Figure 4] FIG. 4 shows a representative embodiment in which a nanofiber sheet is applied to the tear trough. [Figure 5] FIG. 5 shows a representative embodiment of applying a nanofiber sheet to the neck. [Figure 6A] FIG. 6A shows a representative embodiment of applying the nanofiber sheet of the present invention to the face. [Figure 6B] Figure 6B is a photograph of the nanofiber sheet of the present invention actually applied to the face, demonstrating that the nanofiber sheet becomes transparent upon application. [Figure 7] FIG. 7 shows a typical embodiment of applying the nanofiber sheet of the present invention to the face. [Figure 8] FIG. 8 shows a typical embodiment of applying the nanofiber sheet of the present invention to the face. [Figure 9] FIG. 9 shows a typical embodiment of applying the nanofiber sheet of the present invention to the face. [Figure 10] FIG. 10 shows a representative embodiment of applying the nanofiber sheet of the present invention to the neck. [Figure 11] FIG. 11 shows a representative embodiment of applying a nanofiber sheet of the present invention to the jaw. [Figure 12] FIG. 12 shows a preferred embodiment of applying the nanofiber sheet of the present invention to the face. [Figure 13] FIG. 13 shows a typical embodiment in which the nanofiber sheet of the present invention is applied to the corner of the eye. DETAILED DESCRIPTION OF THE INVENTION

[0040] Hereinafter, embodiments of the present invention will be described. Note that "%" means weight / weight percent unless otherwise specified.

[0041] (nanofiber sheet) The nanofiber sheet is not limited to, but may be, for example, a nanofiber sheet produced by electrospinning.

[0042] Nanofibers are ultrafine fibers on the order of submicrons or nanometers, and typically have a length of 100 μm or more and a fiber diameter in the range of 30 to 2000 nm (particularly 50 to 800 nm). The nanofiber sheet of the present invention is preferably prepared by forming nanofibers spun to a fiber diameter of 80 to 800 nanometers into a sheet on a substrate such as a nonwoven fabric, film, or paper.

[0043] The fiber diameter of the nanofiber is more preferably 200 to 500 nm, and most preferably 100 to 300 nm. The density of the nanofiber sheet is not limited, but is preferably 0.3 to 2.0 g / m 2 and more preferably 0.3 to 1.0 g / m 2 is.

[0044] The nanofiber sheet of the present invention may be, for example, a composite nanofiber that has been thermally laminated with other materials. For example, a nanofiber sheet that has been thermally laminated with PP spunbond or PP spunlace to increase the overall thickness may be used. For example, the spunbond or spunlace portion can be used as a reservoir for an active ingredient. When spunbond or spunlace is thermally laminated for reinforcement purposes, for example, 10 g to 40 g / m 2 Use, but not limited to:

[0045] The thickness of the nanofiber sheet is set within an appropriate range depending on its specific application. There are no limitations on the thickness of the nanofiber sheet, but it is typically set to 0.5 μm to 1000 μm, preferably 1 μm to 500 μm, from the perspective of being able to exert maintenance power when attached to human skin. The thickness of the nanofiber sheet can be measured with a micrometer.

[0046] The basis weight of the nanofiber sheet is also set in an appropriate range depending on the specific application. The basis weight of the nanofiber sheet is 0.1 g / m 2 ~100g / m 2 , especially 0.1g~30g / m 2 It is preferable to set it to 1.5 g / m. 2 The nanofiber sheet of the present invention can be suitably produced by depositing nanofibers on the surface of a smooth substrate, for example, using an electrospinning method (ESD). Figure 1 shows an apparatus for carrying out the electrospinning method. The apparatus for carrying out the electrospinning method shown in the figure is equipped with a syringe, a high-voltage source, and a conductive collector. The syringe is filled with a raw material liquid that will be the raw material for the nanofibers. The high-voltage source is, for example, a DC voltage source of 10 to 50 kV. The apparatus shown in Figure 1 can be operated in the atmosphere. There are no particular limitations on the operating environment, and the temperature can be 20 to 40°C and the humidity can be 30 to 60% RH.

[0047] Polymer compounds that can be used in nanofiber sheets include, but are not limited to, polyvinyl alcohol, polystyrene, polycarbonate, polyacrylic acid, polymethyl acrylate, or acrylic acid-based polymers such as polybutyl acrylate / isopropylacrylamide / polyethylene glycol dimethacrylate copolymer, polyvinyl chloride, polyethylene terephthalate, cellulose, nylon (e.g., nylon 66, nylon 46), polyamide, polyurethane, polyvinyl alcohol, polylactic acid, polycaprolactone, polyethylene glycol, polyglycolic acid, polyethylene vinyl acetate, polyethylene vinyl alcohol, polyvinyl acetate, polyethylene oxide, proteins such as collagen, pullulan, hyaluronic acid, poly-γ-glutamic acid, modified corn starch, β-glucan, polysaccharides such as glucooligosaccharides, polyethylene vinyl alcohol / polylactic acid polymer blends, polymethyl methacrylate / acrylonitrile polymer blends, polyaniline / polyethylene oxide polymer blends, collagen / polyethylene oxide polymer blends, silk / polyethylene oxide polymer blends, and polyaniline / polystyrene polymer blends. Considering compatibility with the skin, particularly preferred are polyvinyl acetate (PVAc), polyacrylic acid (PAA), polyvinyl alcohol (PVA), polyethylene oxide (PEO), proteins such as collagen, pullulan, hyaluronic acid, poly-γ-glutamic acid, modified corn starch, β-glucan, glucooligosaccharides, and various other polysaccharides.

[0048] Preferred water-soluble polymer materials include, but are not limited to, natural polymers such as glucomannan, galacturon, psyllium seed gum, tamarind seed gum, gum arabic, tragacanth gum, soybean water-soluble polysaccharides, alginic acid, carrageenan, laminaran, agar (agarose), fucoidan, and hydroxypropyl methylcellulose, as well as synthetic polymers such as partially saponified polyvinyl alcohol, low-saponified polyvinyl alcohol, polyvinylpyrrolidone (PVP), polyethylene oxide, and sodium polyacrylate. These water-soluble polymer compounds can be used alone or in combination of two or more. Of these water-soluble polymer compounds, pullulan, partially saponified polyvinyl alcohol, low-saponified polyvinyl alcohol, polyvinylpyrrolidone, and polyethylene oxide are recommended from the viewpoint of ease of nanofiber production.

[0049] A particularly preferred polymer compound for use in nanofiber sheets is one prepared based on polyvinyl alcohol. Preferably, the nanofibers contain no water-insoluble polymers and the proportion of water-soluble polymers is 90% or more.

[0050] This nanofiber sheet preferably has the property of shrinking upon contact with water. The uses of the nanofiber sheet are not particularly limited, and by utilizing the various properties exhibited by the nanofibers and the property of shrinking simply by contacting water, the nanofiber sheet can be used as a transparent device for skin maintenance, by adjusting the shape, position, and direction to eliminate looseness and sagging caused by gravity on the neck or face. Furthermore, the nanofiber sheet of the present invention is a transparent sheet that can be adhered tightly and multiple sheets can be stacked on top of each other.

[0051] (base material) The substrate can be a nonwoven fabric or a plastic mesh. The substrate is not limited to, but can be, for example, a sheet made of polyolefins such as high-density polyethylene, medium-density polyethylene, low-density polyethylene, or polypropylene; polyester; polyvinylidene chloride; nylon; chitosan; starch; polyvinyl alcohol; or polyvinyl acetate; or copolymers or modified forms thereof. Particularly preferred are nonwoven fabrics made of polyolefin fibers such as polyethylene (PE) or polypropylene (PP); polyester fibers such as polyethylene terephthalate (PET), polytrimethylene terephthalate (PTT), or polyethylene naphthalate (PEN); polyamide fibers such as nylon; rayon fibers; or other synthetic fibers; or nonwoven fabrics made from a blend of cotton, silk, hemp, pulp (cellulose) fibers, etc. Among these nonwoven fabrics, nonwoven fabrics made of rayon fibers, polyolefin fibers, or polyester fibers are particularly preferred.

[0052] The substrate is preferably a nonwoven fabric made of polypropylene or rayon, and most preferably a heat-treated (spunbonded) nonwoven fabric made of polypropylene or rayon. The substrate used in the present invention may or may not contain a drug, but preferably the substrate does not contain a drug. Preferably, the nonwoven fabric is selected from the group consisting of spunbond, spunlace, and cotton nonwoven fabric.

[0053] (Addition of other components to nanofiber sheets) It is also possible to add other components to the nanofiber sheet. The amount of the other components to be added can be adjusted appropriately depending on the thickness of the nanofiber sheet. Although not limited thereto, the amount of the other components to be added to the nanofiber sheet is typically 0.3 g / m for nanofibers with a thickness of 5 μm. 2 ~3.0g / m 2 and preferably 0.5 g / m 2 ~1.8g / m 2 and more preferably 0.8 g / m 2 ~1.5g / m 2and even more preferably 0.8 g / m 2 ~1.2g / m 2 and most preferably 0.8 g / m 2 ~1.0g / m 2 The amount applied increases in proportion to the increase in thickness. Furthermore, although not limited thereto, the amount of other components added to the nanofiber sheet is typically 1.0 g to 20 g per 1 g of nanofiber sheet, preferably 1.0 g to 5.0 g, more preferably 0.5 g to 2.5 g, even more preferably 0.5 g to 2.0 g, and most preferably 0.5 g to 1.0 g (i.e., 1 g / m 2 For nanofiber sheets, 1.0 g / m 2 ~20g / m 2 and preferably 1.0 g / m 2 ~5.0g / m 2 and more preferably 0.5 g / m 2 ~2.5g / m 2 and even more preferably 0.5 g / m 2 ~2.0g / m 2 and most preferably 0.5 g / m 2 ~1.0g / m 2 That is, in the present invention, other components are added in very small amounts to extremely thin nanofibers (films or nonwoven fabrics).

[0054] The nanofiber sheet of the present invention can be made to exhibit cosmetic effects when applied to the skin by adding glitter. For example, nanofibers can be electrospun by adding crushed glitter powder, fine metal powder, or fine pearl powder to the spinning solution, and when applied to the skin, they can achieve cosmetic effects similar to those achieved with glitter foundation. For example, glitter powder, pearl powder, natural mica, and gold powder can be added.

[0055] As used herein, "glitter" refers to a substance selected from the group consisting of metals (including, but not limited to, gold, silver, tin, and aluminum), mica, shells (e.g., pearl oysters), pearls, and plastics (e.g., laminated plastics) in the form of powder (e.g., fine powder), pulverized material, thin plate (e.g., fine thin plate), and foil (e.g., fine foil).

[0056] The composition applied to the nanofiber sheet may or may not contain an adhesive, but preferably does not contain an adhesive. Because the nanofibers used as the base material for the patch are extremely thin and light, even without the use of an adhesive, the slight adhesive force generated by the composition, such as a water-soluble polymer, applied to the nanofiber allows for long-term application. This also has the advantage of reducing the risk of denaturation of drugs and the like due to drying after application.

[0057] The application of a composition (e.g., a composition containing an active ingredient) to the nanofiber sheet can be carried out by any of a variety of methods. For example, the composition can be applied to the nanofiber sheet by spraying. Preferably, the application of a composition (e.g., a composition containing an active ingredient) to the nanofiber sheet is carried out by an inkjet method.

[0058] The inkjet method has the following advantages compared to the conventional spray method: Inkjet Spray Principle: Liquid is expelled by pressure. Liquid is expelled by pressure. Nozzle: 5~15μ round hole, various shapes Droplet size: constant, various sizes Drop volume: 1 to 10 picoliters, continuously variable Liquid Factors Surface Tension and Viscosity Viscosity Distance between nozzle and print medium: several millimeters, several centimeters or more Liquid loss: Low High Airborne scattering Low High As mentioned above, the inkjet method allows the volume of each droplet to be adjusted in picoliter units, the distance from the nozzle to the printing medium can be shortened, and the entire printer can be easily enclosed, which means that the problem of mist generation (scattering into the air) can be avoided or reduced.Since it is difficult to avoid mist generation with the spray method, avoiding or reducing mist generation is also an advantage of the inkjet method.

[0059] (Inkjet method) In the inkjet method used in the present invention, either the bubble jet (registered trademark) method or the piezo method can be used, but the piezo method is preferred because it does not cause thermal denaturation of the drug. Any inkjet printer can be used, but one that can use high-viscosity ink (e.g., PulsInjector, manufactured by Cluster Technology) is preferred. In the inkjet printer, a nozzle with an inner diameter of preferably 10 μm to 100 μm, more preferably 60 μm, is used.

[0060] Any solution with slight viscosity can be used as a composition (ink) to be applied by the inkjet method. When using a composition for transdermal or topical administration, a liquid formulation with excellent transdermal or topical absorbability is preferably used. Unlike conventional patches, a composition (ink) to be applied by the inkjet method does not need to contain an adhesive for application to the skin.

[0061] The viscosity of the composition (ink) used in the inkjet method is 0 to 1000 mP·s, more preferably 20 to 200 mP·s, and most preferably 80 to 100 mP·s. The surface tension of the composition (ink) is 20 to 70 mN, preferably 30 to 70 mN, and more preferably 50 to 70 mN.

[0062] The composition (ink) applied by the inkjet method may further contain, as necessary, an absorption promoter, a stabilizer, a tackifier, a fragrance, and a thickener, for example, but not limited to, the following: Absorption enhancers include, but are not limited to, glycols, fatty acids such as oleic acid, and fatty acid esters such as isopropyl myristate and isopropyl palmitate. Examples of stabilizers include, but are not limited to, ascorbic acid, sodium alginate, propylene glycol alginate, dibutylhydroxytoluene, butylhydroxyanisole, tocopherol acetate, tocopherol, propyl gallate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate, propyl parahydroxybenzoate, methyl parahydroxybenzoate, and 2-mercaptobenzimidazole. Examples of tackifiers include ester gum, glycerin, hydrogenated rosin glycerin ester, petroleum resin, rosin, polybutene, etc. Examples of fragrances include, but are not limited to, dl-menthol, orange oil, peppermint oil, lemon oil, rose oil, etc. Examples of thickeners include, but are not limited to, carboxymethylcellulose, carrageenan, pectin, agar, etc.

[0063] The composition (ink) may contain any active ingredient. Preferably, the active ingredient is a basic low-molecular-weight substance, more preferably a substance with a molecular weight of 700 or less. Examples of active ingredients include antihistamines (diphenhydramine, chlorpheniramine, etc.), antihypertensives (diltiazem, nicardipine, metoprolol, bisoprolol, propranolol, penbutolol, etc.), antiarrhythmics (mexiletine, etc.), antiparkinsonian drugs (pergolide, bromocriptine, ropinirole, selegiline, amantadine, rotigotine, zonisamide, etc.), bronchodilators (tulobuterol, fenoterol, procaterol, salbutamol, etc.), antiallergics (ketotifen, azelastine, etc.), local anesthetics (lidocaine, dibucaine, etc.), narcotic analgesics (fentanyl, morphine, etc.), urinary tract agents (oxybutynin, tamsulosin, tolterodine, etc.), psychotropic agents (chlorpromazine, bupivacaine, etc.), and the like. lopion, etc.), antidepressants (fluoxetine, paroxetine, citalopram, duloxetine, escyclopram, etc.), antidementia drugs (donepezil, rivastigmine, etc.), expectorants (ambroxol, etc.), anxiolytics (tandospirone, etc.), antipsychotics (quetiapine, aripiprazole, perospirone, etc.), ADHD therapeutic agents (methylphenidate, amoxetine, etc.), osteoporosis therapeutic agents (raloxifene, etc.), breast cancer preventive agents (tamoxifen, etc.), anticancer agents (irinotecan, paclitaxel, etc.), antiobesity drugs (sibutramine, etc.), insomnia relief drugs (zolpidem, etc.), antiemetics (ondansetron, palonosetron, ramosetron, etc.), and the like, and these may be free bases or physiologically acceptable acid addition salts thereof. For example, but not limited to, organic acid addition salts include formate, acetate, lactate, adipate, citrate, tartrate, methanesulfonate, fumarate, maleate, etc., and inorganic acid addition salts include, but are not limited to, hydrochloride, sulfate, nitrate, phosphate, etc. Furthermore, the free base or a physiologically acceptable acid addition salt thereof may be a solvate, hydrate, or non-hydrate.

[0064] The composition (ink) of the present invention may contain a cosmetic ingredient as an active ingredient. Cosmetic ingredients that exhibit effects such as moisturizing agents, whitening agents, and UV absorbers can be blended alone or in combination. For example, moisturizing agents include amino acids, pyrrolidone carboxylic acids, and lactic acids, which are the same as or similar to biological components. Mucopolysaccharides such as hyaluronic acid and chondroitin sulfate, which are closely related to moisturizing the dermis layer, are well-suited to the skin and can be added to the composition (ink) of the present invention as needed. Additionally, polyhydric alcohols such as glycerin, propylene glycol, butylene glycol, and sorbitol have traditionally been widely used as moisturizing agents. These have functions such as retaining moisture. Furthermore, many substances are used as moisturizers, such as protein hydrolysates of soluble collagen, urothelin, keratin, etc., placenta extract extracted from bovine placenta, mucin, a glycoprotein produced and secreted in the gastric mucosa and salivary glands of mammals, chitin and chitosan derived mainly from crab and shrimp shells, bifidobacterium metabolites, yeast fermentation metabolites, yeast extracts, etc. Also, as whitening agents, L-ascorbic acid and its derivatives, hydroquinone and its derivatives, rucinol, edetic acid and its derivatives, placenta extract, t-AMCHA, acerola extract, angelica extract, ellagic acid and its derivatives, spice extract, chamomile extract, chamomile flower extract, urea, kiwi extract, glutathione, tocotrienol, ferulic acid, raspberry ketone, rucinol, uva-ursi extract, pyridoxine dipalmitate, sulfur, kojic acid and its derivatives, glucosamine, etc. Examples of such extracts include, but are not limited to, hydroxycinnamic acid or a derivative thereof, glutathione, arnica extract, Scutellaria root extract, Morus alba extract, Bupleurum Root extract, Safflower extract, Ganoderma Lucidum mycelium culture or an extract thereof, linden extract, peach leaf extract, Angelica Root extract, Sophora Root extract, Jew's wort extract, Angelica Root extract, Job's Wort extract, persimmon leaf extract, Rhubarb extract, Peony extract, Hamamelis virginiana extract, Horse Chestnut extract, Hypericum perforatum extract, and oil-soluble licorice extract.UV absorbers include ferulic acid (HMC), tetrahydroxybenzophenone (oxybenzone 3, THB), ethyl para-aminobenzoate (ethyl PABA, EAB), dihydroxybenzophenone (oxybenzone 1, DHB), dihydroxydimethoxybenzophenone (oxybenzone 6, DHDMB), 2-hydroxy-4-methoxybenzophenone (oxybenzone 3, HMB), 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate (EBP), 4-tert-butyl-4'-methoxydibenzoylmethane (BMB), 2-ethylhexyl paramethoxycinnamate (EMC), octyl salicylate (ESA), 2-cyano-3,3-phenylprop-2-enoic acid 2-ethylhexyl ester (octocrylene, ECA), and drometrizole. These include, but are not limited to, siloxane (BPS), 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine (octyltriazone, TEAT), 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol] (MBP), 2-ethylhexyl paradimethylaminobenzoate (EDB), homomenthyl salicylate (HS), phenylbenzimidazole sulfonic acid (PBS), hydroxymethoxybenzophenone sulfonic acid (oxybenzone 4, OXB4), sodium hydroxymethoxybenzophenone sulfonate (oxybenzone 5, OXB5), and sodium dihydroxydimethoxybenzophenone disulfonate (oxybenzone 9, OXB9).

[0065] (X-shaped and cross-shaped nanofiber sheets) A typical shape of an X-shaped nanofiber sheet is shown in Figure 2. In Figure 2, a first linear portion and a second linear portion intersect at an intersection to form an X. The angle between the first linear portion and the second linear portion is θ. The distance from the first end of the first linear portion to the intersection is A, and the distance from the second end to the intersection is B. The lengths of the first linear portion and the second linear portion may be the same or different.

[0066] The ratio of A to B is not limited to, but is from 0.5 to 2.5 to 2.5 to 0.5, preferably from 1 to 2 to 2 to 1, and more preferably 1 to 1. The angle θ is from 15 to 165 degrees, preferably from 30 to 150 degrees, more preferably from 60 to 120 degrees, and most preferably 90 degrees.

[0067] The nanofiber sheet and its shape can be provided, which can solve problems caused by looseness and sagging of the face and neck by punching out the sheet into this shape and placing it on a predetermined surface in a predetermined way, and can solve problems caused by looseness and sagging of the skin not only before makeup application but also after makeup application.

[0068] Representative examples of X-shaped nanofiber sheets for use in the present invention include, but are not limited to, the following: An X-shaped nanofiber sheet, in which θ is 90 degrees, the length of the first linear portion and the second linear portion is 70 mm, and the width of the first linear portion and the second linear portion is 20 mm; An X-shaped nanofiber sheet in which θ is 90 degrees, the length of the first linear portion and the second linear portion is 70 mm, and the width of the first linear portion and the second linear portion is 10 mm; and An X-shaped nanofiber sheet in which θ is 90 degrees, the length of the first linear portion and the second linear portion is 50 mm, and the width of the first linear portion and the second linear portion is 10 mm.

[0069] In a preferred embodiment of the X-shaped nanofiber sheet used in the present invention, θ is 90 degrees, the length of the first linear portion and the second linear portion is 70 mm, and the width of the first linear portion and the second linear portion is 20 mm.

[0070] An X-shaped nanofiber sheet in which the angle between the first linear portion and the second linear portion is 90 degrees is called a cross-shaped nanofiber sheet. Typically, in a cross-shaped nanofiber sheet, one of the first linear portion and the second linear portion is arranged horizontally and the other is arranged vertically. Representative examples of cross-shaped nanofiber sheets used in the present invention are as follows, but are not limited to: A cross-shaped nanofiber sheet, in which the length of the first linear portion and the second linear portion is 70 mm and the width of the first linear portion and the second linear portion is 20 mm; A cross-shaped nanofiber sheet in which the length of the first linear portion and the second linear portion is 70 mm and the width of the first linear portion and the second linear portion is 10 mm; and A cross-shaped nanofiber sheet, in which the length of the first linear portion and the second linear portion is 50 mm and the width of the first linear portion and the second linear portion is 10 mm.

[0071] In a preferred embodiment of the cross-shaped nanofiber sheet used in the present invention, the length of the first linear portion and the second linear portion is 70 mm, and the width of the first linear portion and the second linear portion is 20 mm.

[0072] If necessary, a linear nanofiber sheet may be added to the X-shaped or cross-shaped nanofiber sheet.

[0073] (V-shaped nanofiber sheet) Instead of the above-mentioned X-shaped and cross-shaped nanofiber sheets, a V-shaped nanofiber sheet, i.e., a nanofiber sheet in which one end of the first linear portion and one end of the second linear portion form an intersection, can be used in the present invention.

[0074] The angle θ is between 15 and 165 degrees, preferably between 30 and 150 degrees, more preferably between 60 and 120 degrees, and most preferably 90 degrees.

[0075] The nanofiber sheet and its shape can be provided, which can solve problems caused by looseness and sagging of the face and neck by punching out the sheet into this shape and placing it in a predetermined position, and can solve problems caused by looseness and sagging of the skin not only before makeup application but also after makeup application.

[0076] If necessary, a linear nanofiber sheet may be added to the V-shaped nanofiber sheet.

[0077] (Y-shaped nanofiber sheet) Instead of the above-mentioned X-shaped and cross-shaped nanofiber sheets and V-shaped nanofiber sheets, a Y-shaped nanofiber sheet, i.e., a Y-shaped nanofiber sheet formed by adding a third linear portion that shares an intersection point to a V-shaped nanofiber sheet, can be used in the present invention.

[0078] If necessary, a linear nanofiber sheet may be added to the Y-shaped nanofiber sheet.

[0079] (Attachment of the nanofiber sheet of the present invention) The nanofibers of the present invention can be applied to any part of the skin, typically the face (e.g., around the eyes, nasolabial folds, under-eye bags, etc.), neck, and hands, but are not limited to these.

[0080] Methods for fixing a nanofiber sheet to an object to which it is to be attached include, but are not limited to, a method in which purified water or lotion is applied or sprayed onto the nanofiber sheet to adhere it to the skin, and the nanofiber sheet is then placed on the skin by the adhesive force generated when the aqueous liquid comes into contact with the nanofiber sheet.

[0081] The maintenance power of the nanofiber sheet can be generated by the purified water or water in the lotion used to attach the nanofiber sheet to the skin, or it can be restored by spraying purified water on the nanofiber sheet after it has been placed on the skin.

[0082] When the nanofiber sheet of the present invention is applied to the corners of the eyes, it is preferably applied so that the corners of the eyes are sandwiched between the sheet's corners (Figure 3).When the nanofiber sheet of the present invention is applied to the nasolabial folds, it is preferably applied so that the sheet's corners of the mouth are sandwiched between the sheet's corners (Figure 3).

[0083] When the nanofiber sheet of the present invention is applied to the tear trough, it is preferably applied so that the first linear portion is positioned along the tear trough (FIG. 4).

[0084] When the nanofiber sheet of the present invention is applied to the neck, it is preferably applied so that the included angles sandwich a horizontal or vertical line (FIG. 5).

[0085] Further embodiments for attaching the nanofiber sheet of the present invention are shown in FIGS. [Example]

[0086] The present invention will now be described in more detail using examples for the sole purpose of illustrating the present invention, but the technical scope of the present invention is limited only by the claims and is not limited by the following examples.

[0087] (Example 1: Study on sheet shape) A water-soluble polymer compound, polyvinyl alcohol (GOHSENOL, manufactured by Mitsubishi Chemical Corporation), was dissolved in purified water to a concentration of 8.4% to prepare a spinning solution, which was then electrospun to form a nanofiber sheet on a PP spunbond placed on a target electrode. The electrospinning conditions were as follows: Applied voltage: 50kV Distance between syringe and collector: 250 mm ·Aqueous solution discharge amount: 1.0ml / hr ·Environment: 26℃, 50% RH.

[0088] Two rectangular nanofiber sheets prepared as described above were applied to the skin surface of the target area (eyes, nasolabial folds, under-tear bags, neck) as shown in Figures 3 to 5, with the θ (theta angle) between the first and second linear portions varied from 15° to 90°, and the ratio of the distance from the first end of the first linear portion to the intersection point (shown as "A" in the table below) to the distance from the second end to the intersection point (shown as "B" in the table below) was 1:1 to 2.5:0.5 for both the first and second linear portions. The first and second linear portions of the sheet applied to the eyes, nasolabial folds, or under-tear bags were 1 cm wide and 5 cm long. The first and second linear portions of the sheet applied to the neck were 1 cm wide and 20 cm long. The skin at each application site was first wetted with purified water, and the sheet was pressed against the area to allow the sheet to fully absorb the moisture. The base material was then peeled off, and the nanofiber sheet was applied in an X-shape. If the sheet was not sufficiently moistened and appeared white, purified water was sprayed onto the sheet using a spray bottle or similar to thoroughly wet it. As shown in the table below, looseness and sagging improved over time. The results of correction under various conditions are shown in the table below.

[0089] [Table 1]

[0090] [Table 2]

[0091] [Table 3]

[0092] [Table 4]

[0093] As shown in the above results, it was found that the shape of the sheet is preferably such that two sheets intersect with each other at an angle of 30 to 90 degrees, and that the ratio of the distance from the first end of the first linear portion to the intersection point (shown as "A" in the table below) to the distance from the second end to the intersection point (shown as "B" in the table below) is preferably 1:1 to 2:1.

[0094] By punching out a nanofiber sheet to meet the above-mentioned shape requirements and applying it to the desired area, problems caused by loose and sagging skin on the face, neck, etc. The present invention provides a nanofiber sheet, its shape, and a method for using the same that can alleviate problems caused by loose and sagging skin not only before makeup application but also after makeup application.

[0095] (Example 2: Examination of the components and basis weight of nanofiber sheets) Polyvinyl alcohol (Gohsenol, manufactured by Mitsubishi Chemical Corporation) was dissolved in purified water to a concentration of 8.4% as a water-soluble polymer compound, and electrospinning was performed to form a nanofiber sheet on a PP spunbond placed on a target electrode. The electrospinning conditions were as follows: Applied voltage: 50kV Distance between syringe and collector: 250 mm ·Aqueous solution discharge amount: 1.0ml / hr ·Environment: 26℃, 50% RH The nanofiber sheet prepared as described above was punched into an X-shape and applied to the skin surface according to the target area (around the eyes, nasolabial folds, tear troughs, and neck) as shown in Figures 3 to 5. Specifically, the inward X-shape was formed such that the theta angle (θ) between the first and second linear portions was 45 degrees, and the ratio of the distance from the first end of the first linear portion to the intersection (shown as "A" in the table below) to the distance from the second end to the intersection (shown as "B" in the table below) was 1.0:1.0 for both the first and second linear portions. The first and second linear portions were 1 cm wide and 5 cm long. The first and second linear portions of the sheet to be applied to the neck were 1 cm wide and 20 cm long. The skin at each application site was first wetted with purified water, and the sheet was pressed against the area to allow the sheet to fully absorb the moisture before peeling off the base material and applying the X-shaped nanofiber sheet. If the sheet was not sufficiently moistened and appeared white, the sheet was thoroughly wetted with purified water using a spray bottle. As shown in the table below, looseness and sagging improved over time. The results of correction under various conditions are shown in the table below.

[0096] [Table 5]

[0097] JPEG2025169775000007.jpg182156

[0098] In the prior art, many products have been developed or sold that use nanofibers to reduce the appearance of sagging skin and wrinkles on the face and neck, or to slow their progression. However, none of these products are standardized in terms of the performance, application method, usage, or shape of the sheet itself. Furthermore, the effects obtained are insufficient.

[0099] The inventors discovered that excellent results could be achieved by manufacturing a nanofiber sheet made of electrospun water-soluble polymer into a specific shape. They determined that the shape of the present invention is the right size, angle, and direction to resolve the problems caused by looseness and sagging of the neck and face due to gravity, and completed the transparent prosthesis.

[0100] Example 3: Application to the face and neck Representative embodiments of the nanofiber sheet of the present invention applied to the face and neck are shown in FIGS.

[0101] As shown in Figure 6B, the nanofiber sheet of the present invention becomes transparent when applied.

[0102] Figures 8, 9 and 12 show embodiments for full facial application, with the application method shown in Figure 12 being particularly preferred.

[0103] FIG. 13 shows an embodiment in which the nanofiber sheet of the present invention is applied to the corner of the eye.

[0104] (Example 4: Lame-containing nanofiber sheet) By adding glitter to the nanofiber sheet of the present invention, it can exert a cosmetic effect when applied to the skin. Nanofibers electrospun by adding crushed glitter powder, fine metal powder, fine pearl powder, etc. to the spinning solution have been found to exert a cosmetic effect similar to that of makeup with glitter foundation when applied to the skin. Details are as follows.

[0105] 1. Nanofiber with finely powdered glitter An 8% aqueous solution of PVA (GOHSENOL EG-40C, manufactured by Mitsubishi Chemical) was prepared, and glitter powder (LG neo, manufactured by Horikin Hakufun Co., Ltd.) with a particle size of 10 to 20 μm was added to make the final concentration 5%. PVA nanofibers were obtained by electrospinning the solution onto PP spunbond under the following conditions. Electrospinning conditions: voltage 36Kv, distance to equipment 40cm, humidity in chamber 50%, basis weight 2.0g / m 2 .

[0106] 2. Nanofiber containing pearl powder A 10% aqueous solution of PVA (Gohsenol EG-40C, manufactured by Mitsubishi Chemical) was prepared, and pearl powder (Akoya pearl oyster nacre powder, manufactured by Doi Shinju Co., Ltd.) with a particle size of 3 to 5 μm was added to make a final concentration of 8%, and PVA nanofibers were obtained by electrospinning onto PP spunbond under the electrospinning conditions described in 1.

[0107] 3. Golden nanofiber containing natural mica Nanofibers made of water-soluble polymers, including PVA nanofibers, are transparent and appear white due to light scattering. Much research has been done on coloring nanofibers, but no success has been achieved. Recently, we have succeeded in preparing gold-colored nanofibers by adding natural mica to PVA nanofibers and electrospinning them. We have also succeeded in obtaining a sheet that, when applied to the skin, creates a makeup effect, giving the appearance of gold dust. The manufacturing method is as follows: A 15% aqueous solution of PVA (Gohsenol EG-40C, manufactured by Mitsubishi Chemical) was prepared, and 50% ethanol was added to reduce the viscosity to a final concentration of 10%. Natural mica powder (manufactured by Yamaguchi Mica Co., Ltd.) with particle sizes of 30-50 μm was then added and electrospun onto PP spunbond under the electrospinning conditions of 1. Fine powder glitter nanofiber to obtain golden PVA nanofiber.

[0108] 4. Nanofiber using gold powder A 15% aqueous solution of PVA (GOHSENOL EG-40C, manufactured by Mitsubishi Chemical) was prepared, and gold mud (particle size 0.1-1 μm, manufactured by Horikin Hakufun Co., Ltd.) was added to the solution to a final concentration of 1%. The solution was then electrospun onto a PP spunbond nonwoven fabric under the electrospinning conditions described above to obtain a gold nanofiber sheet.

[0109] The glitter that can be used in the present invention is not limited to the above specific examples. For example, aluminum powder, mica powder, glitter, pearl oyster powder, and pearl powder can also be used to produce the nanofiber sheet of the present invention. [Industrial Applicability]

[0110] By applying the nanofiber sheet of the present invention to the skin, it is possible to alleviate skin problems caused by looseness and sagging skin. Furthermore, by adding glitter to the nanofiber sheet of the present invention, it is possible to achieve cosmetic effects. [Explanation of symbols]

[0111] 1. Polymer solution or molten polymer 2. High voltage equipment 4. Target electrode a. Application of voltage b Generation of an electrically charged jet

Claims

1. A nanofiber sheet obtained by electrospinning a water-soluble polymer, the nanofiber sheet including an X-shape and a cross-shape or a V-shape consisting of a first linear portion and a second linear portion.

2. 2. The nanofiber sheet according to claim 1, wherein the angle between the first linear portion and the second linear portion is between 30 degrees and 90 degrees.

3. The nanofiber sheet has a basis weight of 0.1 g / m ２ ~100g / m ２ The nanofiber sheet according to claim 1,

4. The nanofiber sheet according to claim 1 , wherein the proportion of the water-soluble polymer in the nanofiber sheet is 90% by weight or more.

5. The nanofiber sheet of claim 1 , comprising glitter.

6. A brace comprising a nanofiber sheet in which a water-soluble polymer is electrospun onto a nonwoven fabric or plastic mesh as a nanofiber substrate, wherein the nanofiber sheet has first and second linear portions formed in an X-, cross-, or V-shape, and wherein the nanofiber sheet is fixed to a desired location.

7. 7. The appliance of claim 6, wherein the appliance is transparent and rewritable.

8. 7. The brace of claim 6, wherein the nonwoven fabric is selected from the group consisting of spunbond, spunlace, and cotton nonwoven fabrics.

9. The brace of claim 6 , wherein the angle between the first linear portion and the second linear portion is between 30 degrees and 90 degrees.

10. The nanofiber sheet has a basis weight of 0.1 g / m ２ ~100g / m ２ The orthosis of claim 6 , wherein:

11. The orthosis according to claim 6 , wherein the proportion of the water-soluble polymer in the nanofiber sheet is 90% by weight or more.

12. The appliance of claim 6 , wherein the desired area is selected from the group consisting of the face, neck, and hands.

13. The device according to claim 6, wherein the plurality of nanofiber sheets are all or partly stacked in close contact with each other during the fixing, and the sheets are transparent even when stacked in close contact with each other.

14. The appliance of claim 6 , wherein the nanofiber sheet comprises glitter.

15. A device for reducing looseness and sagging skin, comprising a first linear nanofiber sheet electrospun from a water-soluble polymer, and a second linear nanofiber sheet electrospun from a water-soluble polymer, wherein the first nanofiber sheet and the second nanofiber sheet are attached to the skin so as to form an X-shape or a V-shape.

16. 16. The brace of claim 15, wherein the angle between the first nanofiber sheet and the second nanofiber sheet is between 30 and 90 degrees.

17. The basis weight of the nanofibers in the first nanofiber sheet and the second nanofiber sheet is 0.1 g / m ２ ~100g / m ２ 16. The orthosis of claim 15, wherein:

18. The brace according to claim 15, wherein the proportion of the water-soluble polymer in the first nanofiber sheet and the second nanofiber sheet is 90% by weight or more.

19. The appliance of claim 15 , wherein the skin is skin in an area selected from the group consisting of the face, neck, and hands.

20. The appliance of claim 15 , wherein the nanofiber sheet comprises glitter.

21. A method for reducing looseness and sagging skin, comprising the step of applying to the skin a first linear nanofiber sheet electrospun from a water-soluble polymer and a second linear nanofiber sheet electrospun from a water-soluble polymer, wherein the applied first and second nanofiber sheets form an X-shape or a V-shape.

22. 22. The method of claim 21, wherein the angle between the first nanofiber sheet and the second nanofiber sheet is between 30 and 90 degrees.

23. The basis weight of the nanofibers in the first nanofiber sheet and the second nanofiber sheet is 0.1 g / m ２ ~100g / m ２ 22. The method of claim 21, wherein:

24. The method of claim 21 , wherein the proportion of the water-soluble polymer in the first nanofiber sheet and the second nanofiber sheet is 90% by weight or more.

25. 22. The method of claim 21, wherein the skin is skin in an area selected from the group consisting of the face, neck, and hands.

26. 22. The method of claim 21, wherein the nanofiber sheet comprises a glitter.

27. A nanofiber sheet containing lame, in which a water-soluble polymer is electrospun, wherein the proportion of the water-soluble polymer in the nanofiber sheet is 90% by weight or more.

28. The nanofiber sheet has a basis weight of 0.1 g / m ２ ~100g / m ２ The nanofiber sheet according to claim 27,

29. 28. The nanofiber sheet of claim 27, wherein the glitter is selected from the group consisting of metal powder, mica powder, pearl powder, and crushed laminated plastic.

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