Skin preparations

Abstract

New applications of diamond nanoparticles and platinum nanoparticles are provided. [Solution] A skin preparation for external use containing diamond nanoparticles, platinum nanoparticles, and an organic sulfur compound. A fascia relaxant comprising said skin preparation for external use. An agent for improving negative mood states comprising said skin preparation for external use. An agent for improving body flexibility comprising said skin preparation for external use.

Description

[Technical field]

[0001] The present invention relates to an external preparation for skin. [Background technology]

[0002] Nanoparticles that emit far-infrared rays and cause electron transfer based on plasmon resonance, such as diamond nanoparticles and platinum nanoparticles, are known to improve sleep quality when used in clothing, for example (see, for example, Patent Document 1). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] International Publication No. 2021 / 245969 Summary of the Invention [Problem to be solved by the invention]

[0004] The present invention aims to further utilize diamond nanoparticles and platinum nanoparticles, and to provide new applications for these particles. [Means for solving the problem]

[0005] The present inventors have found that by adding an organic sulfur compound to diamond nanoparticles and platinum nanoparticles, it is possible to prepare a skin topical agent that can exert various effects. The present invention is based on these findings.

[0006] The present invention includes the following aspects. [1] A skin topical agent containing diamond nanoparticles, platinum nanoparticles, and an organic sulfur compound. [2] The topical skin preparation described in [1], wherein the organic sulfur compound is methylsulfonylmethane. [3] A topical skin preparation according to [1] or [2], wherein the content of diamond nanoparticles is 10 mass% or less based on the total amount of the topical skin preparation. [4] The topical skin preparation according to any one of [1] to [3], wherein the content of diamond nanoparticles is 1 mass% or less based on the total amount of the topical skin preparation. [5] The topical skin preparation according to any one of [1] to [4], wherein the content of platinum nanoparticles is 10 mass% or less based on the total amount of the topical skin preparation. [6] The topical skin preparation according to any one of [1] to [5], wherein the content of platinum nanoparticles is 1 mass% or less based on the total amount of the topical skin preparation. [7] The topical skin preparation according to any one of [1] to [6], wherein the mass ratio of the content of platinum nanoparticles to the content of diamond nanoparticles is 0.01 to 100. [8] A fascia relaxant comprising an external skin preparation according to any one of [1] to [7]. [9] An agent for improving a negative mood state, comprising an external skin preparation according to any one of [1] to [8].

[10] A body flexibility improving agent comprising an external skin preparation according to any one of [1] to [9]. Effect of the Invention

[0007] According to the present invention, new applications of diamond nanoparticles and platinum nanoparticles are provided. [Brief description of the drawings]

[0008] [Figure 1] 1 shows the results of imaging diagnosis in Test Example 1, where (a) is the thickness of the left lateral head of the gastrocnemius muscle of subject A before application of the topical skin preparation of Example 1, and (b) is the thickness of the left lateral head of the gastrocnemius muscle of subject A immediately after application of the topical skin preparation of Example 1. [Diagram 2] 1 shows the results of imaging diagnosis in Test Example 1, where (a) is the thickness of the left lateral head of the gastrocnemius muscle of subject B before application of the topical skin preparation of Example 1, and (b) is the thickness of the left lateral head of the gastrocnemius muscle of subject B immediately after application of the topical skin preparation of Example 1. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0009] Hereinafter, an embodiment of the present invention will be described, however, the present invention is not limited to the following embodiment.

[0010] The topical skin preparation according to this embodiment is based on the novel finding that it has the effect of relaxing fascia and muscles when applied to human skin.

[0011] Fascia is a general term for the membrane of connective tissue, mainly collagenous, that exists under the skin and connects or stabilizes, encases, and separates muscles and other internal organs. Muscle tissue covers all elements of the body in three dimensions, and abnormal adhesion between fascia reduces the sliding properties and mobility of the fascia and all tissues, such as muscle tissue deep inside it, and restricts the maintenance of antigravity posture and smooth, functional, and efficient movement. In addition to supporting blood vessels, nerves, and lymphatic vessels, fascia also has the very important mechanical function of allowing them to pass through. Twisting of fascia affects not only muscle tissue, but also blood vessels and nerves, and further causes biochemical and immunological changes in the nature of the fascia. As a result of these, functional abnormalities can extend to the entire body. Relaxing the fascia to return the twist to its original state improves the mobility and extensibility between muscle tissues or between muscle tissue and other components, helping muscle tissue and other components to function normally.

[0012] Fascia can become dysfunctional due to inflammation, pain, abnormal muscle tone, biased muscle activity, abnormal posture, chronic physical or mental stress, etc. Dysfunction can cause fascial shortening, adhesions, changes in density of the intercellular substance of connective tissue, nutritional disorders in that area, limited range of motion of joints, disuse atrophy and weakening of muscle tissue, decreased activity, poor alignment, circulatory insufficiency, abnormal tactile sensation, etc.

[0013] The skin external preparation of the present embodiment has the effect of relaxing fascia and untwisting it.As a result, it improves the flexibility of the body, such as improving the range of motion of muscle tissue and joints, and also suppresses cramps, muscle spasms, etc.The relaxation of fascia also reduces subjective tension, which makes it easier to feel the recovery of fatigue and can also suppress the sensation of pain.As a result, the skin external preparation of the present embodiment has the effect of improving negative mood, and can also improve vitality.

[0014] In this specification, fascia relaxation means to eliminate abnormal adhesion and / or atrophy of the fascia and to return the fascia to a normal state. "Fascia relaxation" is also called "fascia release".

[0015] In this specification, the negative mood state includes, among the moods felt by a person, a sense of anger, hostility towards others, a sense of confusion or bewilderment, a depressed state, a sense of fatigue, apathy, tension, anxiety, etc. Improving a negative mood state means that these negative mood states are suppressed and become less easily felt.

[0016] In this specification, physical flexibility includes the ability of fascia and muscles to stretch, the range of motion of joints, etc., and improving physical flexibility means that fascia and muscles become more pliable and easier to stretch, the range of motion of joints increases, etc.

[0017] The topical skin preparation according to this embodiment contains at least diamond nanoparticles, platinum nanoparticles, and an organic sulfur compound.

[0018] The diamond nanoparticles according to this embodiment are nano-sized diamond particles, and refer to diamond particles with an average particle size of less than 1 μm. In this specification, the average particle size means the 50% volume average particle size (D50) (hereinafter the same). The average particle size is determined by a dynamic light scattering method (for example, a method of measuring using an electrophoretic light scattering photometer model ELS-8000).

[0019] As the diamond nanoparticles, for example, crude diamond (also called blended diamond or BD) synthesized by bombardment and GD (Generated Diamond) obtained by refining BD can be used.

[0020] BD produced by the bombardment method is composed of diamond and graphite with a diameter of several tens to several hundreds of nm, and is an aggregate of diamond units (diamond nanoparticles) of a very small nanocluster size of 1.7 to 7 nm that are tightly aggregated. In other words, it is a tight aggregate of at least four, usually several tens to several hundreds, and in some cases several thousand diamond nanoparticles. BD particles are thought to have a core / shell structure in which the surface of diamond is covered with graphite-based carbon, and the surface of the graphite-based carbon has many hydrophilic functional groups such as -COOH and -OH, and has extremely good affinity with solvents having -OH groups such as water, alcohol, and ethylene glycol, and is quickly dispersed in these solvents. Among them, it has the best dispersibility in water. BD contains a very small amount of fine (1.5 nm or less) amorphous diamond, graphite, and non-graphite carbon ultrafine particles.

[0021] The impurities in BD can be divided into: (i) water-soluble electrolytes (ionized); (ii) hydrolyzable groups and ionic materials (such as salts of functional surface groups) hydrogen bonded to the diamond surface; (iii) water-insoluble materials (surface-attached impurities, insoluble salts, insoluble oxides); (iv) volatile materials; and (v) materials that are incorporated or encapsulated in the diamond crystal lattice.

[0022] (i) and (ii) are formed during the purification process of GD. The water-soluble electrolyte (i) can be removed by washing with water, but it is preferable to treat it with an ion exchange resin to remove it more effectively. The water-insoluble impurities (iii) consist of separated microparticles such as metals, metal oxides, metal carbides, metal salts (sulfates, silicates, carbonates), surface salts that cannot be separated, surface metal oxides, etc. To remove these, it is preferable to convert them into a soluble form with an acid. The volatile impurities (iv) can be removed by heat treatment at 250 to 400 °C in a vacuum of about 0.01 Pa.

[0023] For diamond nanoparticles, it is not necessary to completely remove the impurities from the BD, but it is preferable to remove 40 to 95% of the impurities (i) to (iii). The ratio of graphite to diamond can be adjusted by changing the conditions of the bombardment method and / or the amount of impurities by changing the purification conditions of the BD.

[0024] GD is obtained as a dispersion of GD. The dispersion of GD is produced by oxidizing a diamond-non-diamond mixture (initial BD) obtained by explosive detonation, followed by neutralization by adding a basic material that is volatile or whose decomposition reaction product becomes volatile, and separating the layer containing diamond.

[0025] The oxidation treatment step is composed of an oxidative decomposition treatment using nitric acid, followed by an oxidative etching treatment using nitric acid. The oxidative etching treatment is composed of a first oxidative etching treatment and a second oxidative etching treatment, the first oxidative etching treatment is preferably carried out at a pressure and temperature higher than those of the oxidative decomposition treatment, and the second oxidative etching treatment is preferably carried out at a pressure and temperature higher than those of the first oxidative etching treatment. The oxidation treatment step is preferably carried out multiple times at 150°C to 250°C and 14 to 25 atm for at least 10 to 30 minutes each.

[0026] After the oxidative etching process, a neutralization process is carried out to decompose and remove the nitric acid. The dispersion neutralized with a basic material is separated into a diamond-containing phase and a diamond-free phase by adding water and then decanting the mixture.

[0027] After the diamond-containing phase is separated, the dispersion is further washed with nitric acid, and the lower phase dispersion containing the purified diamond particles is separated from the upper phase effluent. This separation is performed by leaving the dispersion after the nitric acid washing treatment to stand.

[0028] The lower phase dispersion containing the purified diamond particles is adjusted to a pH of preferably 4 to 10, more preferably 5 to 8, and most preferably 6 to 7.5, and the diamond particle concentration is adjusted to preferably 0.05 to 16 mass %, more preferably 0.1 to 12 mass %, and most preferably 1 to 10 mass %.

[0029] The GD thus obtained has an elemental composition of 72-89.5% carbon, 0.8-1.5% hydrogen, 1.5-2.5% nitrogen, and 10.5-25% oxygen. Of the total carbon, 90-97% is diamond crystal, and 10-3% is non-diamond carbon. The average particle size (primary particles) is 2-50 nm. In the X-ray diffraction spectrum (XD) using Cu and Kα rays as a radiation source, the Bragg angle (2Φ±0.2°) has the strongest peak at 43.9°, characteristic strong peaks at 73.5° and 95°, a strongly distributed halo at 17°, and substantially no peak at 26.5°. In addition, the specific surface area is 1.5×10 5 m 2 / kg or more, substantially all of the surface carbon atoms are bonded to heteroatoms, and the dispersion is 0.5 m 3 The diamond particles having a total absorption space of 0.05 to 16 parts by mass / kg or more are contained. The particle size of the GD particles is obtained by dynamic light scattering measurement using an electrophoretic light scattering photometer model ELS-8000.

[0030] The average particle size of the diamond nanoparticles is preferably 10 nm or more, 20 nm or more, or 100 nm or more, and is preferably 200 nm or less, and more preferably 100 to 200 nm.

[0031] The specific gravity of diamond nanoparticles is 2.50-3.45g / cm 3 and preferably 2.63 to 3.38 g / cm 3 More preferably, it is 2.75 to 3.25 g / cm 3 The specific gravity of diamond nanoparticles is determined by the ratio of graphite to diamond, and the specific gravity of diamond is set to 3.50 g / cm. 3 , the specific gravity of graphite is 2.25g / cm 3 If we calculate the ratio of diamond to graphite, the specific gravity is 2.63g / cm 3 corresponds to a composition of 30% diamond and 70% graphite by volume, with a specific gravity of 3.38 g / cm 3 corresponds to a composition of 90% diamond and 10% graphite by volume. Similarly, a material with a specific gravity of 2.75 g / cm 3 is 40% diamond and 60% graphite by volume, with a specific gravity of 3.25g / cm 3 corresponds to a composition of 80% by volume of diamond and 20% by volume of graphite. The specific gravity is 2.87 g / cm 3 corresponds to a composition of 50% diamond and 50% graphite by volume. The specific gravity is 2.63 g / cm 3 If it is less than 3.38 g / cm3, coloring due to graphite may become a problem. 3 Above this value, the far-infrared radiation effect is saturated, which is disadvantageous in terms of cost.

[0032] The content of diamond nanoparticles contained in the skin topical preparation is preferably 0.0001% by mass or more, 0.0003% by mass or more, 0.0005% by mass or more, or 0.0008% by mass or more, based on the total amount of the skin topical preparation, from the viewpoint of further improving the effect of relaxing fascia and muscles, and is preferably 10% by mass or less, 5% by mass or less, or 3% by mass or less, from the viewpoint of suppressing aggregation of diamond nanoparticles, and more preferably 1% by mass or less, 0.5% by mass or less, 0.3% by mass or less, or 0.1% by mass or less, from the viewpoint of suppressing blackening of the skin topical preparation. The content of diamond nanoparticles contained in the skin topical preparation may be 0.0005 to 0.5% by mass, based on the total amount of the skin topical preparation.

[0033] The platinum nanoparticles according to this embodiment are nano-sized platinum particles, and refer to platinum particles having an average particle size of less than 1 μm.

[0034] The platinum nanoparticles can be obtained as platinum nanocolloids, for example, by the method described below.

[0035] That is, the method for producing platinum nanocolloids includes the steps of adding a peptide or glucosamine compound as compound A represented by formula (1) or formula (2) as a reducing agent to a solution in which a precious metal-containing compound containing platinum has been dissolved, adding an alkali to assist the reducing properties of compound A, and forming precious metal microparticles (platinum microparticles) by a reduction reaction of the precious metal ions in the precious metal-containing compound. NR 4 R 5 -CR 2 R 3 -CO-R 1 (1) NR 4 R 5 -CR 6 R 7 -CR 2 R 3 -CO-R 1 (2)

[0036] Here, R 1represents hydrogen, a hydroxyl group, an alkoxy group, an amino group, or an atomic group bonded by a peptide bond, and R 2 and R 3 represents a hydrogen atom, an alkyl group, or a substituted alkyl group, and R 4 and R 5 represents a hydrogen atom, an alkyl group, a substituted alkyl group, or an acetyl group, and R 6 and R 7 respectively represent hydrogen, an alkyl group or a substituted alkyl group.

[0037] In the above manufacturing method, preferably, the solution is an aqueous solution. More preferably, in the step of adding an alkali, the alkali is added so that the pH of the aqueous solution is 10 or higher. More preferably, in the step of forming precious metal fine particles, the precious metal fine particles are dispersed in the aqueous solution to form a precious metal colloid. Even more preferably, after the step of forming the precious metal fine particles to form the precious metal colloid, the method further includes a step of centrifuging the aqueous solution to separate it into a precipitate and a supernatant, and a step of removing the supernatant and taking out the precipitate.

[0038] In another preferred embodiment of the above-mentioned manufacturing method, the solution is a solution of an organic solvent. More preferably, after the step of forming the precious metal fine particles, the method further comprises a step of leaving the solution to stand to separate it into a precipitate and a supernatant, and a step of removing the supernatant to extract the precipitate. Even more preferably, after the step of removing the supernatant to extract the precipitate, the method further comprises a step of adding water to the precipitate to obtain an aqueous precious metal colloid. Even more preferably, after the step of obtaining the precious metal colloid, the method further comprises a step of concentrating the precious metal colloid by ultrafiltration or ultracentrifugation. Even more preferably, the method further comprises a step of adding an organic solvent protective agent to the solution, and after the step of removing the supernatant to extract the precipitate, the method further comprises a step of adding an organic solvent to the precipitate to obtain an organic solvent-based precious metal colloid.

[0039] Compound A, which is a peptide, is represented by the formula (1) or (2): 1 is an α- or β-amino acid with a hydroxyl group, R 1R is an alkoxy group, such as an α- or β-amino acid ester; R is an acetylated α- or β-amino acid compound; 1 Examples of peptides include peptides in which the N-terminus is an α-amino acid, which is an atomic group connected by a peptide bond.

[0040] Compound A, which is a glucosamine compound, is represented by the formula (1): 1 is hydrogen and R 2 is [-CH(OH)-CH(OH)-CH(OH)-CH 2 (OH) 3 , R 4 , R 5 Examples of glucosamine compounds include glucosamine, in which N is hydrogen, and its derivative, N-acetylglucosamine.

[0041] The average particle size of the platinum nanoparticles is preferably 10 nm or more, 20 nm or more, or 100 nm or more, and is preferably 200 nm or less, and more preferably 20 to 200 nm.

[0042] The content of platinum nanoparticles contained in the topical skin preparation is preferably 0.000001% by mass or more, 0.000005% by mass or more, 0.00001% by mass or more, or 0.00005% by mass or more, based on the total amount of the topical skin preparation, from the viewpoint of further improving the effect of relaxing fascia and muscles, and is preferably 10% by mass or less, 5% by mass or less, or 3% by mass or less, from the viewpoint of suppressing aggregation of the platinum nanoparticles, and is more preferably 1% by mass or less, 0.5% by mass or less, 0.3% by mass or less, 0.1% by mass or less, 0.05% by mass or less, 0.01% by mass or less, 0.005% by mass or less, 0.001% by mass or less, 0.0005% by mass or less, or 0.0001% by mass or less, from the viewpoint of suppressing blackening of the topical skin preparation.

[0043] The mass ratio of the platinum nanoparticle content to the diamond nanoparticle content in the skin topical agent (platinum nanoparticle content / diamond nanoparticle content) is preferably 0.01 or more, 0.05 or more, or 0.1 or more, and is preferably 100 or less, 50 or less, or 10 or less. The mass ratio may be 0.01 to 100.

[0044] When the skin external preparation contains diamond nanoparticles and platinum nanoparticles and organic sulfur compounds, it can achieve the effect of relaxing fascia and muscle, the effect against arthritis, and the effect of beauty.As the organic sulfur compounds, for example, compounds having sulfonyl group, sulfonic acid group, sulfonate base (functional group in which hydrogen atom of sulfonic acid is replaced by metal atom, halogen, organic group), thiol group, sulfide group, tetrahydrothiophene ring, and thiophene ring can be mentioned.

[0045] Examples of the organic sulfur compound having a sulfonyl group include methylsulfonylmethane, methylsulfonylethan, and ethylsulfonylethan.

[0046] Examples of organic sulfur compounds having a sulfonic acid group include azulene sulfonic acid, chondroitin sulfate, 2-aminoethanesulfonic acid (taurine), etc. Examples of organic sulfur compounds having a sulfonic acid group include salts of organic sulfur compounds having a sulfonic acid group, such as sodium azulene sulfonate, sodium chondroitin sulfate, and sodium 2-aminoethanesulfonate. The organic sulfur compounds having a sulfonic acid group or a sulfonate group may be compounds having a cyclic structure or compounds not having a cyclic structure.

[0047] Examples of organic sulfur compounds having a thiol group include L-cysteine, acetylcysteine, glutathione, pantetheine, etc. Examples of organic sulfur compounds having a sulfide group include methionine.

[0048] An example of an organic sulfur compound having a tetrahydrothiophene ring is biotin. An example of an organic sulfur compound having a thiophene ring is thiamine.

[0049] From the viewpoint of further improving the effect of relaxing fascia and muscles, the organic sulfur compound is preferably an organic sulfur compound having a sulfonyl group, and more preferably methylsulfonylmethane (DMSO2).

[0050] The molecular weight of the organosulfur compound is preferably 300 or less, 200 or less, 150 or less, or 100 or less, from the viewpoint of further improving the effect of relaxing fascia and muscles.

[0051] The content of the organic sulfur compound contained in the topical skin preparation is preferably 1% by mass or more, 3% by mass or more, or 5% by mass or more, based on the total amount of the topical skin preparation, from the viewpoint of further improving the effect of relaxing the fascia and muscles, and is preferably 20% by mass or less, 15% by mass or less, or 10% by mass or less.

[0052] The skin topical preparation according to the present embodiment may be any of a medicine, a quasi-drug, or a cosmetic. The form of these skin topical preparations is not particularly limited, and for example, the skin topical preparation as a medicine or a quasi-drug may be a liquid, a suspension, an emulsion, a gel, a lotion, an ointment, a sheet agent in which a nonwoven fabric or the like is soaked in a drug solution, or the like. In addition, the skin topical preparation as a cosmetic may be, for example, a skin lotion, an emulsion, a gel, a cream, a beauty essence, a lotion, a skin care cosmetic such as a sheet mask, a foundation, a makeup cosmetic such as a lip balm, or the like. The skin topical preparation may be in the form of an O / W system, a W / O system, a water system, an oil system, or an alcohol system.

[0053] When the skin topical preparation is an emulsion, the emulsion type may be O / W type, W / O type, or multi-layer emulsion. When the skin topical preparation is a cream, the cream type may be O / W type, W / O type, or anhydrous oily. When the skin topical preparation is a gel, the gel type may be aqueous gel, oily gel, or oil gel. When the skin topical preparation is a beauty essence, the beauty essence type may be a transparent or translucent lotion type, an O / W type, W / O type, or W / O / W type emulsion type, an oil type, or a two-liquid mixed type that is mixed when used.

[0054] The skin topical preparation may contain water as a base or carrier that is commonly used in medicines, quasi-drugs, or cosmetics. Examples of water include purified water, hot spring water, deep sea water, etc. Examples of bases or carriers other than water include oil-based bases.

[0055] Examples of oil-based bases include hydrocarbons such as squalane, liquid paraffin, petrolatum, solid paraffin, microcrystalline wax, and ceresin; oils and fats such as olive oil, almond oil, cacao oil, jojoba oil, macadamia nut oil, avocado oil, hardened palm oil, castor oil, sunflower oil, evening primrose oil, and synthetic triglycerides; waxes such as beeswax, lanolin, carnauba wax, and candelilla wax; higher alcohols such as cetanol, stearyl alcohol, behenyl alcohol, hexadecyl alcohol, octyldodecyl alcohol, and cholesterol; synthetic esters such as isopropyl myristate, glycerin triester, pentaerythritol tetraester, and cholesteryl ester; and silicone components such as dimethylpolysiloxane, methylphenylpolysiloxane, and cyclomethicone.

[0056] The skin topical preparation may contain, as other components, appropriate components (additives) that are normally used in medicines, quasi-drugs, or cosmetics. Examples of other components include surfactants, gelling agents, powders, alcohols, water-soluble polymers, film-forming agents, resins, inclusion compounds, antibacterial agents, fragrances, deodorants, salts, pH adjusters (pH buffers), cooling agents, extracts (extracts) derived from plants, animals, or microorganisms, blood circulation promoters, astringents, antiseborrheic agents, moisturizers, softeners, solubilizers, thickeners, preservatives, emulsifiers, binders, chelating agents, keratolytic agents, enzymes, hormones, and vitamins.

[0057] The skin topical preparation may contain alcohols from the viewpoint of providing a refreshing feeling, inhibiting bacterial growth, promoting dissolution of each component, etc. As the alcohol, known alcohols can be used, and examples thereof include ethanol, isopropanol, etc.

[0058] The skin external preparation may contain a moisturizing agent from the viewpoint of protecting the stratum corneum, improving the feeling of use, etc. As the moisturizing agent, a known one can be used, and examples thereof include polyhydric alcohols such as glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol; sugars such as hyaluronic acid, chondroitinic acid, maltitol, and sorbitol; and amino acids such as pyrrolidone carboxylic acid and collagen.

[0059] The skin topical preparation may contain a softening agent from the viewpoint of improving the emollient property of the skin, improving the moisturizing property, improving the feeling of use, etc. As the softening agent, a known one can be used, and examples thereof include vegetable oils such as olive oil and jojoba oil, ester oil, squalane, and lanolin derivatives.

[0060] The skin topical preparation may contain a solubilizer to improve the dissolution of each component. As the solubilizer, a known solubilizer can be used, and examples thereof include surfactants such as polyoxin ethylene alcohol ether.

[0061] The skin external preparation may contain a pH adjuster (pH buffer) from the viewpoint of adjusting the pH. As the pH adjuster (pH buffer), a known one can be used, and examples thereof include citric acid, lactic acid, amino acids, and sodium citrate.

[0062] The skin topical preparation may contain a thickener from the viewpoint of improving the feeling of use, improving the moisturizing property, etc. Known thickeners can be used, and examples of the thickener include alginates, cellulose derivatives, quince seed gum, pectin, pullulan, xanthan gum, gum arabic, Irish moss, tragacanth gum, pullulan, veegum, carboxyvinyl polymers, acrylic acid polymers, laponite, and cetanol.

[0063] The skin topical preparation may contain a fragrance to impart fragrance to the product. Known fragrances can be used, such as geraniol and linalool.

[0064] The skin topical preparation may contain alcohols from the viewpoint of providing a refreshing feeling, inhibiting bacterial growth, promoting dissolution of each component, etc. As the alcohol, known alcohols can be used, and examples thereof include ethanol, isopropanol, etc.

[0065] The skin topical preparation may contain a preservative from the viewpoint of suppressing the activity and proliferation of microorganisms. As the preservative, known preservatives can be used, such as methylparaben, phenoxyethanol, etc.

[0066] The skin topical preparation may contain an emulsifier from the viewpoint of mixing the aqueous phase component and the oil phase component. Known emulsifiers can be used, for example, nonionic surfactants such as glycerin monostearate, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene-polyoxypropylene block polymer, polyoxyethylene hydrogenated castor oil ester, etc.; anionic surfactants such as fatty acid soap, sodium alkyl sulfate, etc.

[0067] The skin topical preparation is used by being applied to the skin. Applying the skin topical preparation to the skin is preferably by spreading it on the skin, and in the case of a sheet preparation or the like, it may be by attaching it to the skin. The skin topical preparation may be used by being applied to the skin when massaging muscles.

[0068] The site to which the external skin preparation is applied is not particularly limited, but is preferably joints such as knees, elbows, and shoulders, as well as the waist and calves.

[0069] The amount and frequency of application of the topical skin preparation to the skin are not particularly limited, and can be set appropriately depending on the age, weight, etc. of the subject.

[0070] By applying the skin preparation according to this embodiment to skin, it can relax fascia, improve negative mood, or improve body flexibility.Therefore, the present invention can be rephrased as a fascia relaxant, a negative mood improver, or a body flexibility improver, which is made of a skin preparation containing diamond nanoparticles, platinum nanoparticles, and organic sulfur compound.The aspect of the skin preparation is as described above.

[0071] The present invention can also be understood as an invention relating to the following embodiments.

[0072] In one embodiment of the present invention, there is provided a method for relaxing fascia, comprising applying to the skin a skin topical agent containing diamond nanoparticles, platinum nanoparticles, and an organosulfur compound.

[0073] In another embodiment of the present invention, there is provided a method for improving a negative mood state, comprising applying to the skin a skin topical preparation containing diamond nanoparticles, platinum nanoparticles, and an organosulfur compound.

[0074] In another embodiment of the present invention, there is provided a method for improving bodily flexibility, comprising applying to the skin an external skin preparation containing diamond nanoparticles, platinum nanoparticles, and an organosulfur compound.

[0075] The aspects of the topical skin preparation in each of the above embodiments are as described above. EXAMPLES

[0076] The present invention will be described in more detail below with reference to examples and comparative examples, although the present invention is not limited to the following examples.

[0077] <Preparation of topical skin preparation> [Example 1] Based on the composition shown in Table 1, the mixture was stirred uniformly while being heated using a stirring device, and then degassed and filtered to prepare an external skin preparation (gel).

[0078] The diamond colloid solution in the raw material is a dispersion of diamond nanoparticles in water. The total content of methylsulfonylmethane, glycerin, 1,3-butylene glycol, cetanol, cetyl ethylhexanoate, ethanol, and glyceryl stearate in the raw material is 15 to 20 mass%.

[0079] [Table 1]

[0080] <Test Example 1: Imaging diagnosis of muscle relaxation by ultrasound examination> The topical skin preparation of Example 1 was applied to the calves of two adults (Subject A: male (55 years old), Subject B: male (57 years old)). Before and immediately after application of the topical skin preparation, the left lateral head of the gastrocnemius muscle was observed during contraction using an ultrasound examination device, and the thickness of the muscle was measured. Images of the observed left lateral head of the gastrocnemius muscle are shown in Figures 1 and 2. Figure 1 shows the observation results of Subject A, and Figure 2 shows the observation results of Subject B, where (a) shows the state before application of the topical skin preparation of Example 1, and (b) shows the state immediately after application of the topical skin preparation of Example 1.

[0081] As shown in Fig. 1, the thickness of the left gastrocnemius lateral head of subject A before applying the skin topical preparation according to Example 1 was 19.5 mm, while the thickness of the left gastrocnemius lateral head after applying the skin topical preparation was 15.5 mm. Also, as shown in Fig. 2, the thickness of the left gastrocnemius lateral head of subject B before applying the skin topical preparation according to Example 1 was 15.2 mm, while the thickness of the left gastrocnemius lateral head after applying the skin topical preparation was 13.1 mm. Therefore, it can be seen that the application of the skin topical preparation according to Example 1 relaxes the fascia around the left gastrocnemius lateral head, and the thickness of the muscle during contraction is reduced.

[0082] [Subjective fatigue level (VAS)] The subjects' subjective sense of fatigue was examined according to the method of the "Fatigue VAS (Visual Analogue Scale) Test" established by the Japan Fatigue Association.

[0083] A double-blind crossover test was conducted on 12 healthy women aged 18 to 21 years old. As a specific example, the subjects themselves selected either the skin topical preparation prepared in Example 1 or a placebo product (a skin topical preparation in Example 1 that does not contain diamond nanoparticles, platinum nanoparticles, and methylsulfonylmethane, but instead contains a moisturizing agent), and the selected skin topical preparation was applied to the back and lower limbs every night after bathing for one week. Fatigue VAS was measured before and after the first application and before and after the final application one week later. This was considered as one course, and after a two-week washout period, a new course was conducted using a different gel from the previous one. The fatigue VAS measurement results are shown in Table 2.

[0084] [Table 2]

[0085] As a result of the above test, it was confirmed that after use of the external skin preparation of Example 1, the subject's sense of fatigue tended to decrease (p=0.078).

Claims

1. Contains diamond nanoparticles, platinum nanoparticles, and organic sulfur compounds, The skin topical preparation, wherein the organic sulfur compound is methylsulfonylmethane.

2. The topical skin preparation according to claim 1, wherein the content of the diamond nanoparticles is 10 mass% or less based on the total amount of the topical skin preparation.

3. The topical skin preparation according to claim 1 or 2, wherein the content of the diamond nanoparticles is 1 mass% or less based on the total amount of the topical skin preparation.

4. The topical skin preparation according to claim 1 or 2, wherein the content of the platinum nanoparticles is 10 mass% or less based on the total amount of the topical skin preparation.

5. The topical skin preparation according to claim 1 or 2, wherein the content of the platinum nanoparticles is 1 mass% or less based on the total amount of the topical skin preparation.

6. The skin topical preparation according to claim 1 or 2, wherein the mass ratio of the content of the platinum nanoparticles to the content of the diamond nanoparticles is 0.01 to 100.

7. A fascia relaxant comprising the topical skin preparation according to claim 1 or 2.

8. 3. An agent for improving a negative mood state, comprising the topical skin preparation according to claim 1 or 2.

9. A body flexibility improving agent comprising the topical skin preparation according to claim 1 or 2.

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