Apparatus for amplification of nucleic acids

a technology of nucleic acids and apparatuses, applied in the field of apparatus for amplifying nucleic acids, can solve the problems of reducing the portability of the associated apparatus, and bulky and costly conventional instruments for real-time pcr. the effect of suppressing the inherent noise and improving the noise suppression

US20190002955A1Inactive Publication Date: 2019-01-03ANITOA SYST
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
Publication Date
2019-01-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

Described herein is a chip-based apparatus for amplifying nucleic acids, a cartridge housing the apparatus, and methods of using the apparatus for amplification of nucleic acids. More specifically, this invention provides integrated semiconductor chip, manufactured with standard semiconductor manufacturing process, with on-chip circuitry to perform thermal management and optical sensing necessary for amplification of nucleic acids. The apparatus and methods embodied in this invention makes it possible to build a disease diagnosis and prognosis tool that is easy to use, portable and disposable.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of U.S. patent application Ser. No. 14 / 128,486, now issued as U.S. Pat. No. 9,988,668, having an international filing date of June 25, 2012, which is a U.S. national phase application under 35 U.S.C. § 371 of International Application No. PCT / US2012 / 044090, filed on Jun. 25, 2012, which claims the priority benefit of U.S. Provisional Application No. 61 / 500,523, filed on Jun. 23, 2011, the disclosures of each of which are incorporated herein by reference in their entirety.BACKGROUND OF THE INVENTION

[0002] Described herein is a chip-based apparatus for amplifying nucleic acids, a cartridge housing the apparatus, and methods of using the apparatus for amplification of nucleic acids. More specifically, this invention provides integrated circuit semiconductor chip, manufactured with standard semiconductor manufacturing process, to perform thermal management and optical sensing necessary for on-chip amplificati...

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[0054]Definitions

[0055]Terms used in the claims and specification are defined as set forth below unless otherwise specified.

[0056]The term “nucleic acids” refers to biological molecules that include DNA (deoxyribonucleic acid) and RNA (ribonucleic acid), which are essential for life. Together with proteins, nucleic acids make up the most important macromolecules; each is found in abundance in all living things.

[0057]The term “semiconductor” refers to a material with electrical conductivity due to electron flow (as opposed to ionic conductivity) intermediate in magnitude between that of a conductor and an insulator. Semiconductor materials are the foundation of modern electronics, including radio, computers, telephones, and many other devices.

[0058]The term “microprocessor” refers to a device that incorporates the functions of a computer's central processing unit (CPU) on a single integrated circuit (IC, or microchip). It is a multipurpose, programmable, clock-driven, and register-ba...