Systems and methods for manufacturing accommodating intraocular lenses

Abstract

The present technology' generally relates to systems and methods for manufacturing accommodating intraocular lenses (AIOLs). In some embodiments disclosed herein, a self-aligning fixture assembly includes an anterior mandrel, a posterior mandrel, and an actuator coupled to move the anterior mandrel toward or away from the posterior mandrel. The anterior mandrel can be configured to hold an anterior component of an AIOL base. The posterior mandrel can be configured to hold a posterior component of the AIOL base. In some embodiments, the anterior or posterior mandrel includes at least one alignment feature configured to align the anterior component with the posterior component. In some embodiments, the anterior or posterior mandrel includes one or more apertures such that a vacuum source can apply a vacuum suction force to keep the anterior or posterior component adhered to the anterior or posterior mandrel oriented upside down.

Description

SYSTEMS AND METHODS FOR MANUFACTURINGACCOMMODATING INTRAOCULAR LENSESCROSS-REFERENCE TO RELATED APPLICATION(S)

[0001] The present application claims the benefit of U.S. Provisional Patent ApplicationNo. 63 / 588,853, filed Oct. 9, 2023, and U.S. Provisional Patent Application No. 63 / 633,248, filed Apr. 12, 2024, the disclosures of which are incorporated herein by reference in their entireties.TECHNICAL FIELD

[0002] The present technology relates to systems and methods for manufacturing accommodating intraocular lenses (AIOLs).BACKGROUND

[0003] Cataracts can affect a large percentage of the worldwide adult population with clouding of the native crystalline lens and resulting loss of vision. Patients with cataracts can be treated by native lens removal and surgical implantation of a synthetic intraocular lens (IOL). Worldwide, there are millions of IOL implantation procedures performed annually. In the U.S., there are 3.5 million cataract procedures performed, while worldwide there are over 20 million annual procedures performed.

[0004] Although IOL implantation procedures can be effective at restoring vision, conventional IOLS have several drawbacks. For example, many prior IOLS are not able to change focus as a natural lens would (known as accommodation). Other drawbacks of conventional IOLs include refractive errors that occur after implantation and require glasses for correcting distance vision, or in other cases the IOLs can be effective in providing good far vision, but patients need glasses for intermediate and near vision.

[0005] Several multi-focal IOLs have been developed to address these drawbacks, but they too can have drawbacks. For example, although multi-focal IOLs generally perform well for reading and distance vision, in at least some instances such multi-focal IOLs may cause significant glare, halos, reduced contrast sensitivity, and other visual artifacts.

[0006] AIOLs have been proposed to provide accommodative optical power in response to the distance at which a patient views an object. However, such AIOLs are generally still in development and have different drawbacks. For example, prior AIOLs can provideinsufficient accommodation after implantation or produce suboptimal refractive correction of the eye. The amount of accommodation of the prior AIOLs can also decrease after implantation in at least some instances. The prior AIOLs can also be too large to be inserted through a small incision of the eye and may require the incision to be somewhat larger than would be ideal. Also, at least some of the prior AIOLs can be unstable when placed in the eye, which can lead to incorrect accommodation and other errors.

[0007] Improved implantable intraocular lenses that accommodate with the natural mechanisms of controlling focusing of the eye that overcome at least some of the above deficiencies would be desirable. Ideally, such improved AIOLs would provide increased amounts of accommodation when implanted, provide refractive stability, introduce few if any perceptible visual artifacts, and allow the optical power of the eye to change from far vision to near vision in response to the distance of the object viewed by the patient.BRIEF DESCRIPTION OF THE DRAWINGS

[0008] Many aspects of the present technology can be better understood with reference to the following drawings. The components in the drawings are not necessarily draw n to scale. Instead, emphasis is placed on illustrating clearly the principles of the present technology. Furthermore, components can be shown as transparent in certain views for clarity of illustration only and not to indicate that the component is necessarily transparent. Components may also be shown schematically.

[0009] FIGS. 1A and IB are perspective views of an AIOL configured in accordance with embodiments of the present technology.

[0010] FIG. 1C is a side cross-sectional view of a base of the AIOL taken along line 1C-1C of FIG. IB.

[0011] FIG. 2 is an exploded view of a self-aligning fixture assembly with an AIOL base configured in accordance with embodiments of the present technology.

[0012] FIGS. 3A-3C are top perspective, bottom perspective, and cross-sectional views, respectively, of an anterior component holder of the self-aligning fixture assembly of FIG. 2.

[0013] FIGS. 4A-4C are top perspective, bottom perspective, and enlarged perspective views, respectively, of a postenor component holder of the self-aligning fixture assembly of FIG. 2.

[0014] FIGS. 5A-5C illustrate operating stages of the self-aligning fixture assembly of FIG. 2 in accordance with embodiments of the present technology.

[0015] FIGS. 6A and 6B are perspective and cross-sectional views, respectively, of another self-aligning fixture assembly configured in accordance with embodiments of the present technology.

[0016] FIGS. 7A and 7B are perspective and side views, respectively, of an AIOL base with temporary alignment tabs configured in accordance with embodiments of the present technology7.

[0017] FIGS. 7C-7E illustrate operating stages of aligning the AIOL base of FIG. 7A in accordance with embodiments of the present technology.

[0018] FIGS. 8A and 8B are perspective and enlarged perspective views, respectively, of an automated alignment system configured in accordance with embodiments of the present technology.

[0019] FIGS. 9A and 9B are perspective views of an anterior components tray and an AIOL base tray, respectively, configured in accordance with embodiments of the present technology7.

[0020] FIGS. 10A and 10B illustrate target adhesive application regions on an anterior component and a posterior component, respectively, configured in accordance with embodiments of the present technology7.

[0021] FIG. 11 illustrates a graphical user interface showing views from cameras of the automated alignment system of FIG. 8A.

[0022] FIGS. 12A and 12B are side and perspective views, respectively, of an attachment system configured in accordance with embodiments of the present technology.

[0023] FIG. 13 is an enlarged perspective view of another attachment system configured in accordance with embodiments of the present technology.

[0024] FIGS. 14A and 14B are perspective and cutaway perspective views, respectively, of a posterior mandrel configured in accordance with embodiments of the present technology7.

[0025] FIGS. 15A and 15B are perspective and cutaway perspective views, respectively, of an anterior mandrel configured in accordance with embodiments of the present technology.

[0026] FIGS. 16A-18 illustrate posterior mandrels configured in accordance with various embodiments of the present technology.

[0027] FIGS. 19A and 19B are top camera and perspective views, respectively, of an attachment process at a misaligned stage in accordance with various embodiments of the present technology.

[0028] FIGS. 20 A and 20B are top camera and perspective views, respectively, of an attachment process at an aligned stage in accordance with various embodiments of the present technology7.

[0029] FIGS. 21A and 21B are enlarged perspective and perspective views, respectively, of an attachment process at an attachment stage in accordance with various embodiments of the present technology.

[0030] FIG. 22 is a perspective view of an attachment process at a final stage in accordance with various embodiments of the present technology.

[0031] FIGS. 23A and 23B are perspective views of a posterior mandrel configured in accordance with embodiments of the present technology.

[0032] FIGS. 24A and 24B are perspective views of an anterior mandrel configured in accordance with embodiments of the present technology.

[0033] FIGS. 25-28 illustrate an attachment process at various stages in accordance with embodiments of the present technology.

[0034] FIGS. 29-30B illustrate a post-attachment process at various stages in accordance with embodiments of the present technology.

[0035] FIGS. 31A-31C illustrate an anterior mandrel configured in accordance with embodiments of the present technology7.

[0036] FIG. 32 is a perspective view of a suction component configured in accordance with embodiments of the present technology.

[0037] FIG. 33 is a top view of a gripper arm configured in accordance with embodiments of the present technology.

[0038] FIG. 34 is a perspective view of the gripper arm of FIG. 33 gripping the anterior mandrel of FIG. 31 A configured in accordance with embodiments of the present technology.

[0039] FIG. 35 is a top view of another gripper arm configured in accordance with embodiments of the present technology.

[0040] FIG. 36 is a cross-sectional view of yet another gripper arm configured in accordance with embodiments of the present technology.

[0041] FIG. 37 is a perspective view of an anterior mandrel configured in accordance with embodiments of the present technology.

[0042] FIG. 38 is a perspective view of a rotary stage included in the anterior mandrel of FIG. 37 and configured in accordance with embodiments of the present technology.

[0043] FIGS. 39A and 39B are perspective top and bottom views, respectively, of a base holder included in the anterior mandrel of FIG. 37 and configured in accordance with embodiments of the present technology.DETAILED DESCRIPTION

[0044] The present technology is directed to systems and methods for manufacturing AIOLs. An AIOL can include multiple components that need to be precisely aligned and attached together to ensure long-term reliability and operation of the AIOL, and avoid inadvertent alteration of the AIOL’s intended optical power. Embodiments of the present technology include systems and methods for precisely aligning and / or attaching AIOL components during the manufacturing / assembly process. In some embodiments disclosed herein, a self-aligning fixture assembly includes an anterior component holder, a posterior component holder, and an actuator coupled to move the anterior component holder toward or away from the posterior component holder. The anterior component holder can be configured to hold an anterior component of an AIOL base. The posterior component holder can be configured to hold a posterior component of the AIOL base, and can include at least one alignment feature configured to align the anterior component with the posterior component.

[0045] In some embodiments, a method for aligning an anterior component and a posterior component of an AIOL base includes applying an adhesive to a first alignment tab and to a second alignment tab. and engaging the anterior component with the posterior component such that the first alignment tab interfaces the second alignment tab. The first alignment tab can extend radially from the anterior component, and the second alignment tab can extend radially from the posterior component. The method can then include inserting the engaged anterior and posterior components in an alignment structure. After the adhesive is cured, the method can further include removing the engaged anterior and posteriorcomponents from the alignment structure, and removing the first and second alignment tabs from the anterior and posterior components. In some embodiments, the first alignment tab includes a pin, and the second alignment tab includes an aperture configured to receive the pin. In some embodiments, the alignment structure includes a recess configured to receive the first and second alignment tabs.

[0046] In some embodiments, an automated alignment system for manufacturing an AIOL includes a rotational stage, a first linear stage, a second linear stage, an adhesive applicator, a camera, and a controller. The rotational stage can be configured to rotate an AIOL component. The first linear stage and the second linear stage can be configured to move the rotational stage along a first axis and a second axis, respectively. The adhesive applicator can apply an adhesive to the AIOL component, and the camera can be positioned to view the AIOL component. The controller can be configured to control the rotational stage, the first linear stage, the second linear stage, and the adhesive applicator based on an adhesive application plan.

[0047] In some embodiments, an attachment system includes a robotic arm that can lift and rotate a mandrel supporting an anterior or posterior component. The mandrel can include one or more apertures through which a vacuum source can apply a vacuum suction force to the anterior or posterior component. When the robotic arm rotates the mandrel to an upside down orientation, the vacuum suction force can keep the anterior or posterior component adhered to the mandrel. The robotic arm can then bring the upside down mandrel to another mandrel supporting the other of the anterior or posterior component for attachment. The anterior and / or posterior component can have adhesives applied thereon to facilitate the bonding.

[0048] Specific details of various embodiments of the present technology are described below with reference to FIGS. 1A-36. Although many of the embodiments are described below with respect to manufacturing AIOLs and associated systems, other embodiments are within the scope of the present technology. Additionally, other embodiments of the present technology can have different configurations, components, and / or procedures than those described herein. For instance, self-aligning fixture assemblies configured in accordance with the present technology may include elements and features beyond those described herein, or other embodiments may not include several of the elements and features shown and described herein.

[0049] As used herein, the use of relative terminology, such as “about,’' “approximately,” “substantially” and the like refer to the stated value plus or minus ten percent. For example, the use of the term “about 100” refers to a range of from 90 to 110, inclusive. In instances in which the context requires otherwise and / or relative terminology is used in reference to something that does not include a numerical value, the terms are given their ordinary’ meaning to one skilled in the art.

[0050] FIGS. 1A and IB are perspective views of an adjustable or accommodating intraocular lens 100 (“AIOL 100”) configured in accordance with embodiments of the present technology. The AIOL 100 can include an adjustable or base lens structure 102 (“base 102”) and a fixed power and / or fixed depth of focus lens 104 (“fixed lens 104”) that can be removably coupled to the base 102. For example, the fixed lens 104 includes one or more tabs 118 (FIG. IB) that can fit into one or more grooves or slots 112 (FIGS. IB and 1C) extending radially outward toward an outer perimeter of the base 102.

[0051] FIG. 1C is a cross-section of the base 102 taken along line 1C-1C of FIG. IB. As best seen in FIG. 1C, the base 102 can include a first or anterior component 106 and a second or posterior component 108 that can be coupled together (e.g., via adhesives) to form the base 102. The base 102 can define a first fluid chamber or reservoir 122 and a second fluid chamber or reservoir 124, each of which can be filled with a fluid. A channel 126 can extend between and fluidly couple the outer fluid reservoir 122 and the inner fluid reservoir 124 to allow the fluid to flow between the outer fluid reservoir 122 and the inner fluid reservoir 124. The outer fluid reservoir 122 can be defined at least partially between a first or outer wall 128 and a second or inner wall 130 of the first component 106 and / or a first or outer wall 132 and a second or inner wall 134 of the second component 108.

[0052] The base 102 can include an adjustable lens 136 at least partially defined by the inner fluid reservoir 124, a first optical portion 138 of the first component 106 of the base 102, and a second optical portion 140 of the second component 108 of the base 102. The adjustable lens 136 can be positioned posterior to the fixed lens 104 and / or the lens portion 116 thereof. One or both of the first optical portion 138 and the second optical portion 140 can be planar members or optical membranes of the first component 106 and the second component 108, respectively. In at least some embodiments, for example, the adjustable lens 136 has a diopter of between about 5 D and about 7.5 D, such as between about 5.8 D and about 7.3D, any diopter therebetween, or another suitable diopter. Additionally, oraltematively, the diopter of the adjustable lens 136 can have a range of adjustment of up to 1.5D. 3D, 4D, 5D, 7.5D. any range therebetween, or another suitable range.

[0053] In some embodiments, the first component 106 can include a plurality of protrusions or castles 142 arranged around a perimeter of the first optical portion 138 and facing the second optical portion 140. When the first component 106 and the second component 108 are assembled to form the base 102, the castles 142 are positioned to help maintain the inner fluid reservoir 124 therebetween. The castles 142 can also provide surface area onto which adhesives can be applied to bond the first component 106 and the second component 108 together. In some embodiments, adhesives can also be applied at or proximate a gap 107 between the first component 106 and the second component 108. Additional details regarding AIOLs are described in International Patent Application No. PCT / US2022 / 049046, the disclosure of which is incorporated by reference herein in its entirety.

[0054] FIG. 2 is an exploded view of a self-aligning fixture assembly 200 (“assembly 200") with an AIOL base 202 (“base 202") configured in accordance with embodiments of the present technology. The assembly 200 can be used to align a first or anterior component 206 (e.g., similar to or identical to the first component 106 described above with reference to FIG. 1 C) with a second or posterior component 208 (e.g., similar to or identical to the second component 108 described above with reference to FIG. 1C) to form an AIOL base 202 (e.g.. similar / identical to the base 102 of FIGS. 1 A-1C). The assembly 200 can include an anterior component holder 210, a posterior component holder 220, and a weight 230 (e.g., a washer). Further details regarding the anterior component holder 210, posterior component holder 220, and weight 230 are described below with reference to FIGS. 3A-4C.

[0055] Each of the anterior component holder 210 and the posterior component holder 220 can be made from metal (e.g., aluminum, steel), plastic, or other suitable materials. As will be described in further detail with respect to FIGS. 5A-5C, during operation, the anterior component holder 210 and the posterior component holder 220 can be moved relative to one another to align and bond the anterior component 206 and the posterior component 208. As noted previously, it can be important to align the anterior and posterior components 206, 208 properly during assembly of the base 202 because misalignment during assembly can result in undesirable deformation of the components (e.g., off-centered apex, deformed optic curvature). For example, if the components are misaligned, castles of the anterior component 206 (e.g., the castles 142 shown in FIG. 1C) can interfere with proper operation of the posterior component 208.

[0056] FIGS. 3A-3C are top perspective, bottom perspective, and cross-sectional views, respectively, of the anterior component holder 210. FIG. 3C also illustrates the anterior component 206 fitted onto the anterior component holder 210. The anterior component holder 210 can include a first portion 212, a second portion 214, and a third portion 216 arranged concentrically and with different dimensions (e.g., diameter). For example, the first portion 212 can have a first cross-sectional dimension, the second portion 214 can have a second cross-sectional dimension greater than the first cross-sectional dimension, and the third portion 216 can have athird cross-sectional dimension greater than the second cross-sectional dimension. An aperture 218 (e.g., a through-hole) can extend through the first, second, and third portions, 212, 214, 216. In some embodiments, the first, second, and third portions, 212, 214, 216 are integrally formed (e.g., molded, machined from a single component). In some embodiments, the first, second, and third portions, 212, 214, 216 are separate components that are attached together (e.g., welded, fastened).

[0057] In the illustrated embodiment, the first portion 212 and the second portion 214 have annular shapes. The third portion 216 can be shaped generally similar to a fixed lens (e.g., the fixed lens 104) to include one or more tabs 217 (e.g., the one or more tabs 118) extending radially outward. As shown in FIG. 3C. the one or more tabs 217 can be fitted into corresponding one or more slots 207 (e.g., the one or more slots 112) of the anterior component 206 to removably secure the anterior component 206 onto the anterior component holder 210.

[0058] During operation, an actuator component (not shown) configured to lift and / or move the anterior component holder 210 can be coupled to the anterior component holder 210 via the aperture 218. For example, the aperture 218 can comprise a tapped hole and the actuator component can comprise a threaded shaft (e.g., with a 6-32 screw' size). In some embodiments, the actuator component can be coupled to a vibration exciter.

[0059] FIGS. 4A-4C are top perspective, bottom perspective, and enlarged perspective views, respectively, of the posterior component holder 220. FIG. 4C also illustrates the posterior component 208 fitted onto the posterior component holder 220. The posterior component holder 220 can include a body portion 222, a cutout 224 on a side of the body portion 222, a recess 226 (FIG. 4A) on a top surface of the body portion 222, a plurality of alignment features 228 (e.g., bosses) arranged on the top surface of the body portion 222 and around the recess 226, and an aperture 229 (FIG. 4B) extending from a bottom surface of the body portion 222. In some embodiments, the body portion 222 and the alignment features228 are integrally formed (e.g., molded, machined from a single component). In some embodiments, the body portion 222 and the alignment features 228 are separate components that are attached together (e.g., welded, fastened).

[0060] The posterior component 208 can be placed at least partially within the recess 226. In some embodiments, the recess 226 is shaped to correspond to the shape of the posterior component 208. Each of the alignment features 228 can interface grooves along the outer perimeter of the posterior component 208 (e.g., corresponding to the outer flow-through features 114 shown in FIG. IB). The proximal tip of each of the alignment features 228 can have a curvature corresponding to the curvature of the grooves. In the illustrated embodiment, the posterior component 208 includes three alignment features 228. In other embodiments, the posterior component 208 can include a different number of alignment features 228 (e.g., one, two, four, five, six, seven, eight, or more) depending on the number of grooves along the posterior component 208.

[0061] During operation, the cutout 224 and / or the aperture 229 can be used to keep the posterior component holder 220 fixed in position during operation. For example, a support component (not shown) can be coupled to the posterior component holder 220 via the aperture 229. For example, the aperture 229 can comprise a tapped hole and the support component can comprise a threaded shaft (e.g., with a 6-32 screw size). In another example, the groove or cutout 224 can prevent rotation of the posterior component holder 220 relative to the support component.

[0062] FIGS. 5A-5C illustrate operating stages of assembling the AIOL base 202 (FIG. 2) using the self-aligning fixture assembly 200 in accordance with embodiments of the present technology. Referring first to FIG. 5A, the anterior component 206 of the base 202 is secured to the anterior component holder 210 (e.g.. as shown in FIG. 3C) and the posterior component 208 is secured to the posterior component holder 220 (e.g., as shown in FIG. 4C). The anterior component 206 and the posterior component 208 are not yet engaged. In some embodiments, adhesives can be applied to the anterior component 206 and the posterior component 208 at this operating stage.

[0063] Referring next to FIG. 5B, the anterior component holder 210 is moved (e.g., actuated) while the posterior component holder 220 remains stationary such that the anterior component 206 is proximate to or engages the posterior component 208. Each of the alignment features 228 can have a vertical dimension (e.g., height) such that the alignment features 228 interface grooves included along the perimeters of both the anterior component206 and the posterior component 208. By forcing the grooves of both components to align, the alignment features 228 can precisely align the anterior component 206 and the posterior component 208 without the use of precision actuators that control movement of the components along multiple axes.

[0064] Referring next to FIG. 5C, the weight 230 can be placed on the anterior component holder 210. In the illustrated embodiment, the weight 230 includes an aperture 232 with a dimension (e.g.. diameter) such that the first portion 212 of the anterior component holder 210 fits through the aperture 232 and the weight 230 rests atop the second portion 214 of the anterior component holder 210. The weight 230 can apply a downward force (by virtue of gravity) on the anterior component holder 210 to push the anterior component 206 against the posterior component 208, allowing the adhesive to distribute and / or cure.

[0065] FIGS. 6A and 6B are perspective and cross-sectional views, respectively, of a self-aligning fixture assembly 600 (‘‘assembly 600”) configured in accordance with another embodiments of the present technology. The assembly 600 can be generally similar to the assembly 200. For example, the assembly 600 can include the anterior component holder 210 and the weight 230. However, compared to the assembly 200, the assembly 600 includes a different posterior component holder 620. Specifically, alignment features 628 of the posterior component holder 620 have a greater vertical dimension (e.g., height) compared to the alignment features 228 illustrated in FIG. 4A. The alignment features 628 can contact and prevent the weight 230 from compressing the base 202 beyond a predetermined distance. In other w ords, the alignment features 628 have a vertical dimension that defines a minimum thickness of the base 202 that the weight 230 can compress the base 202 to. This can be advantageous by preventing damage to the base 202 from over-compression.

[0066] FIGS. 7A and 7B are perspective and side views, respectively, of an AIOL base 702 (“base 702”) with temporary alignment tabs 710. 720 configured in accordance with embodiments of the present technology. The alignment tabs 710, 720 can be used to align an anterior component 706 with a posterior component 708 when, for example, applying an adhesive therebetw een to form the base 702. The base 702 can be an example of the base 102 illustrated and described above with respect to FIGS. 1A-1C.

[0067] Referring to FIGS. 7A and 7B together, the anterior component 706 can include a plurality of first alignment tabs 710 extending radially from the perimeter of the anterior component 706. Each of the first alignment tabs 710 can include a protrusion or pin 712 extending downward (e.g., toward the posterior component 708). The posterior component708 can include a plurality of second alignment tabs 720 extending radially from the perimeter of the posterior component 708. Each of the second alignment tabs 720 can include an aperture 722 configured to receive the pin 712 of a corresponding one of the first alignment tabs 710. FIG. 7A illustrates three of each of the first alignment tabs 710 and the second alignment tabs 720. In other embodiments, the number of each of the first alignment tabs 710 and the second alignment tabs 720 can be one, two, four, five, six, seven, eight, or more. In some embodiments, the first and second alignment tabs 710, 720 are integrally formed with the anterior component 706 and the posterior component 708, respectively (e.g., molded together).

[0068] Referring to FIG. 7B, the base 702 is shown w ith the first and second alignment tabs 710, 720 aligned and the pin 712 extending through the aperture 722. In some embodiments, the first and second alignment tabs 710. 720 can be dimensioned such that they define a gap 730 between the anterior component 706 and the posterior component 708. The gap 730 can provide space for adhesives after the anterior component 706 and the posterior component 708 are engaged together. The adhesives can be naturally confined to the gap 730 via capillary action.

[0069] FIGS. 7C-7E illustrate operating stages of aligning and assembling the base 702 in accordance with embodiments of the present technology. The base 702 can be aligned using an alignment structure 740 having a plurality of recesses 742 and a plurality of holes 744. When the anterior component 706 and the posterior component 708 are disengaged (FIG. 7C), adhesive can be applied to the castles 732. In some embodiments, adhesive is also applied between the first and second alignment tabs 710, 720 to sen e as lubrication during alignment. When the anterior component 706 and the posterior component 708 are engaged (FIG. 7D), adhesive can be applied therebetween proximate to the perimeter of the base 702 (e.g., in the gap 730). Optionally, excess adhesive protruding beyond the walls of the base 702 can be removed.

[0070] The base 702 with adhesives applied can then be inserted into the alignment structure 740 (FIG. 7E). In particular, the first and second alignment tabs 710, 720 can be at least partially inserted into the recesses 742 and the pins 712 can be at least partially inserted into the holes 744 for improved alignment between the anterior component 706 and the posterior component 708. Once the adhesives are cured or otherwise solidified, the base 702 can be removed from the alignment structure 740 and the first and second alignment tabs 710, 720 can be cut off or otherwise removed from the base 702.

[0071] FIGS. 8A and 8B are perspective and enlarged perspective views, respectively, of an automated alignment system 800 (“system 800,?) configured in accordance with embodiments of the present technology. The system 800 can be used to operate a self-aligning fixture assembly (e.g., the assembly 200) and apply adhesives with high precision to form an AIOL base (e.g., the base 102). Referring first to FIG. 8A, the system 800 can include a frame structure 810, a first linear stage 812, a second linear stage 814, a third linear stage 816. electronic components 802, an applicator housing 820 coupled to the third linear stage 816. and an application assembly 830. The first and second linear stages 812, 814, can be operated to move at least part of the application assembly 830 along a first axis (e.g., x-axis) and / or a second axis (e.g., y-axis) perpendicular to the first axis, respectively. The third linear stage 816 can be operated to move at least part of the application assembly 830 along a third axis (e.g., z-axis) perpendicular to the first axis and the second axis. The electronic components 802 and / or the applicator housing 820 can be mounted to the frame structure 810. In some embodiments, the applicator housing 820 is mounted to the third linear stage 816.

[0072] Referring next to FIG. 8B, the application assembly 830 can include a rotational stage 832 and a lighting structure 834 (e.g., illustrated as a ring light) suspended above the rotational stage 832. An AIOL base to which adhesive is to be applied (and optionally a selfaligning fixture assembly such as the assembly 200) can be coupled to the rotational stage 832. The rotational stage 832 can be mounted to the first and / or second linear stages 812, 814. The lighting structure 834 can be mounted to the first, second, and / or third linear stages 812, 814, 816. The system 800 can further include an adhesive applicator 822 (e.g., a syringe) mounted to the applicator housing 820 (not shown in FIG. 8B). a first camera 840 positioned and oriented to capture a top- view of the AIOL base, and a second camera 850 positioned and oriented to capture a side view of the AIOL base. In some embodiments, the first camera 840 is coupled to the third linear stage 816 and the second camera 850 is coupled to the first and / or second linear stages 812, 814. FIG. 8B also illustrates a first tray 860 that can hold components with no adhesives applied yet, and a second tray 870 that can hold components after adhesives are applied by the system 800.

[0073] During operation of the system 800, once the AIOL base components are secured to the rotational stage 832 (e.g., via vacuum hold or other lightweight fixturing), the electronic components 802 can be operated to independently control the first, second, and third linear stages 812. 814, 816 as well as the rotational stage 832. The adhesive applicator 822 can be used (e g., controlled manually, controlled via the electronic components 802,operated autonomously) to apply adhesives to desired regions of the AIOL base components. For example, the first and second linear stages 812, 814 can be operated to move the AIOL base and the second camera 850 along the x- and y-axes, the rotational stage 832 can be operated to rotate the AIOL base about the z-axis, and the third linear stage 816 can be operated to move the first camera 840 and / or the adhesive applicator 822 along the z-axis. The lighting structure 834 can provide adequate lighting to the AIOL base for the first and second cameras 840. 850. The first and second cameras 840 can be used to ensure that the adhesives are applied to proper regions of the AIOL base components. The system 800 can then align and engage the anterior component with the posterior component (e.g., as shown in FIGS. 5A-5C). The system 800 can be controlled precisely to avoid damage to the AIOL base and maintain the as-molded optic quality of the AIOL base.

[0074] The system 800 can apply adhesives to the AIOL base components with high precision and thereby enable adequate, proper, and low-stress bonding therebetween. In some embodiments, the system 800 is controlled such that when the anterior and posterior components are engaged, a wall gap that ranges between about 10pm and 90pm is maintained therebetween. When applying the adhesive, the system 800 can use capillary action as an aiding mechanism to wick the adhesive between certain parts, and can rely on the stiff castlebond region to minimize distortion.

[0075] FIGS. 9A and 9B are perspective views of an anterior components tray 900 and an AIOL base tray 901, respectively, configured in accordance with embodiments of the present technology. Referring first to FIG. 9A, the anterior components tray 900 can hold a plurality of anterior component mounts 910, each configured to receive and hold an anterior component 906. In some embodiments, the anterior component mounts 910 can include one or more tabs (not shown) (e.g., the one or more tabs 217) extending radially outward and configure to removably secure the anterior component 906 onto the anterior component mount 910. In the illustrated embodiment, the anterior component mounts 910 are arranged in five rows and five columns on the tray 900. In other embodiments, the anterior component mounts 910 can be arranged differently on the tray 900. In some embodiments, the system 800 can use the tray 900 to easily and quickly apply adhesives to multiple anterior components 906, such as by translating and / or rotating the tray 900. In some embodiments, the system 800 includes components to pick up-and-place individual ones of the anterior components 906 for individual adhesive deposition.

[0076] Referring next to FIG. 9B, the AIOL base tray 901 can hold a plurality of selfaligning fixture assemblies 920 (e.g., the assembly 200). each holding an AIOL base 902 with adhesives applied. In some embodiments, after the system 800 applies adhesives to one AIOL base 902, the system 800 can place the self-aligning fixture assembly the AIOL base 902 on the tray 901 and repeat the process until the tray 901 holds multiple assemblies 920. The tray-901 can then be transported to a curing oven to cure the adhesives on multiple AIOL bases902 together.

[0077] FIGS. 10A and 10B illustrate target adhesive application regions on the anterior component 906 and a posterior component 908, respectively, in accordance with embodiments of the present technology. Referring first to FIG. 10A, the adhesive can be applied to each of the castles 942 and an outer rim 928 of the anterior component 906, as indicated by the shaded regions. In some embodiments, the adhesive can be applied while the anterior component 906 rests on one of the anterior component mounts 910. Referring next to FIG. 10B, the adhesive can be applied to an outer rim 932 of the posterior component 908, as indicated by the shaded region. In some embodiments, the adhesive can be applied while the posterior component 908 rests on the posterior component holder 620, as shown (or the posterior component holder 220).

[0078] FIG. 11 illustrates a graphical user interface (GUI) 1100 showing views from the first camera 840 and the second camera 850 of the system 800. Specifically, the GUI 1 100 includes a first panel 1 110 depicting the view from the second camera 850 (e.g., a side view) and a second panel 1120 depicting the view from the first camera 840 (e.g., a top view). In some embodiments, an integrated image processing system is employed to dynamically adjust the adhesive application path based on real-time readings from the first camera 840 and the second camera 850.

[0079] In some embodiments, an artificial intelligence or machine learning model (hereinafter “AL / ML model”) is used to assess adhesive distribution and to determine whether the adhesive has been or is being applied properly. For example, the AI / ML model can be trained with data sets of images of AIOL bases with or without adhesives paired with information regarding adhesive application (e.g., where the adhesive has been applied, whether the adhesive application is proper). In some embodiments, the image or video feeds from the first and second cameras 840, 850 can be input to the AI / ML model, and the AI / ML model can output whether the adhesive application is proper or satisfactory. If not proper or satisfactory, the AI / ML model can suggest an adjusted adhesive application or removal plan.In some embodiments, the AI / ML model can output an adhesive application score indicative of the assessment of adhesive distribution and sufficiency.

[0080] FIGS. 12A and 12B are side and perspective views, respectively, of an attachment system 1200 configured in accordance with embodiments of the present technology. The attachment system 1200 includes an actuator or robotic arm 1210, a mount 1220, a top view camera 1232, a first side view camera 1234, a second side view camera 1236, and a third side view camera 1238 (obscured from view). It will be appreciated that the attachment system 1200 can include fewer or more components, and that the illustrated components can have different designs and / or configurations relative to one another.

[0081] The robotic arm 1210 can operate with multiple degrees of freedom, such as along and about six axes. In some embodiments, 16or example, the robotic arm 1210 can comprise the six-axis industrial robot arm, such as a Meca500 commercially available from Mecademic Industrial Robotics of Montreal, Canada. The robotic arm 1210 can be controlled by an operator and / or controlled in an autonomous manner by a processor (not shown). The robotic arm 1210 can include a gripper 1212 positioned at a distal end of the robotic arm 1210. As discussed further herein, the gripper 1212 can be used to pick up and release one or more mandrels, and the robotic arm 1210 can move and rotate the gripper 1212 to position and orient the gripped mandrel in a desired manner.

[0082] The mount 1220 can support one or more mandrels at one or more heights. In the illustrated embodiment, for example, the mount 1220 includes a first platform 1222 for supporting a first mandrel 1242 at a first height and a second platform 1224 for supporting a second mandrel 1244 at a second height. By including the first platform 1222 and the second platform 1224 at different heights, the mount 1220 can provide space for the robotic arm 1210 to operate when moving between and at each of the first and second platforms 1222, 1224.

[0083] The top view camera 1232 can provide a top view of the second platform 1224. As discussed further herein, the top view can be used for alignment of the anterior and posterior components during an attachment process. A light source 1230 can be positioned adjacent the top view camera 1232 to provide top-down lighting during the attachment process. Each of the first side view camera 1234, the second side view camera 1236, and the third side view camera 1238 can provide a side view of the second platform 1224 from different angles. In some embodiments, the first, second, and third side view cameras 1234. 1236, 1238 are positioned around the second platform 1224 (e.g., at or approximately 120 degrees from one another) to provide equally spaced apart views around the entire secondplatform 1224. In other embodiments, however, the first, second, and / or third side view cameras 1234. 1236, 1238 are positioned around the second platform 1224 at different angles / arrangements relative to each other and the second platform 1224.

[0084] As discussed further herein, the various side views can be used for ensuring proper mating between the anterior and posterior components during the attachment process. In some embodiments, the various camera views can be input to an AL / ML model to assess adhesive distribution and determine whether the adhesive has been or is being applied properly, as discussed above with reference to FIG. 11. Operation of the attachment system 1200 is discussed in further detail below with reference to FIGS. 19A-22.

[0085] FIG. 13 is an enlarged perspective view of another attachment system 1300 configured in accordance with embodiments of the present technology. The attachment system 1300 can include several features generally similar to the features of the system 800 illustrated in FIGS. 8A and 8B. For example, the attachment system 1300 can include a first rail 1302 extending along a first axis, a second rail 1304 extending along a second axis generally perpendicular to the first axis, and a third rail 1306 extending along a third axis generally perpendicular to the first and second axes. The attachment system 1300 can also include a mount 1324 and one or more trays 1362 mounted on the first rail 1302 and the second rail 1304. and a syringe 1350 and a gripper arm 1360 mounted on the third rail 1306.

[0086] The mount 1324 can support a mandrel 1344 holding either an anterior component or a posterior component. In some embodiments, the mount 1324 is motorized to. for example, move vertically along the third axis and / or rotate about the third axis (e.g., as a rotational stage). The one or more trays 1362 can hold multiple mandrels 1344. The gripper arm 1360 can be used to move individual ones of the mandrels 1344 between, for example, the mount 1324 and the trays 1362. In some embodiments, the gripper arm 1360 is not motorized, and instead works in conjunction with the mount 1324 and the trays 1362 to lift and release the mandrels 1344. Embodiments of the gripper arm 1360 are discussed in further detail below with reference to FIGS. 33-36. The syringe 1350 can be supported by a mounting fixture 1352 that can be moved and / or rotated by operating a fine positioner 1354.

[0087] During operation of the attachment sy stem 1300, the gripper arm 1360 can be used to pick up an individual mandrel 1344 holding either an anterior component or a posterior component from one of the trays 1362 and transport the mandrel 1344 to the mount 1324. The syringe 1350 can then be used to apply adhesive material onto the anterior / posterior component held by the mandrel 1344 on the mount 1324. In some embodiments, the syringe1350 is moved to apply the adhesive material at specific portions of the anterior / posterior component. Once the adhesive material is applied, the gripper arm 1360 can be used to move the mandrel 1344 from the mount 1324 to the same or a different one of the trays 1362. In some embodiments, the gripper arm 1360 is rotated by 180 degrees by a rotary actuator 1364 such that the mandrel 1344 is rotated. The flipped anterior component or posterior component can then be attached to a corresponding posterior component or anterior component, respectively, that is oriented upright.

[0088] FIGS. 14A and 14B are perspective and cutaway perspective views, respectively, of a posterior mandrel 1400 configured in accordance with embodiments of the present technology. The posterior mandrel 1400 includes a base portion 1415, a stem portion 1410 coupled to and extending from the base portion 1415, and a plurality of protrusions 1414 extending radially outward and upward to restrict movement of a posterior component 1408 mounted thereon.

[0089] Referring first to FIG. 14A, the base portion 1415 can be relatively wide and heavy to ensure that the posterior mandrel 1400 remains upright when on a surface (e.g., on the first platform 1222). The stem portion 1410 can be relatively narrow to allow a gripper (e.g., the gripper 1212, the gripper arm 1360) to easily and reliably engage the stem portion 1410. In the illustrated embodiment, the stem portion 1410 includes six flat surfaces that can help the gripper better engage the stem portion 1410. The stem portion 1410 can also include a vacuum hole 1412.

[0090] In the illustrated embodiment, the posterior mandrel 1400 includes three protrusions 1414 equally spaced apart around. The posterior component 1408 can be positioned between the three protrusions 1414. In particular, the posterior component 1408 can include three notches 1409a and three elongate rim portions 1409b extending between the three notches 1409a. and the posterior component 1408 can be mounted on the posterior mandrel 1400 such that each of the three protrusions 1414 contacts corresponding ones of the three elongate rim portions 1409b. The protrusions 1414 can be dimensioned and spaced apart to avoid deforming (or excessively deforming) the posterior component 1408. Thus, the protrusions 1414 can avoid affecting the eventual optical power to be provided by the posterior component 1408. Moreover, the shaded portion along the top of the posterior component 1408 can define a target area for adhesive application.

[0091] Referring next to FIG. 14B, the posterior mandrel 1400 includes an interior channel 1420 in fluid communication with the vacuum hole 1412. The base 1415 encloses athreaded plug 1422 that fluidly seals one end of the interior channel 1420. At the other end of the interior channel 1420, the posterior mandrel 1400 includes a plurality of vanes 1418 that split the interior channel 1420 into a plurality of smaller channels that are in fluid communication with the external environment. In the illustrated embodiment, the posterior component 1408 is positioned on top of the vanes 1418. Also, each of the protrusions 1414 can include one or more steps 1416 at different heights to conform to and support the different parts of the posterior component 1408.

[0092] In operation, a vacuum source (not shown) can be connected to the vacuum hole 1412 to create at least a partial vacuum within the interior channel 1420. Because the plug 1422 seals one end of the interior channel 1420, the resulting vacuum suction force is applied to the bottom of the posterior component 1408. Thus, the vacuum source can be used to keep the posterior component 1408 on the posterior mandrel 1400 even if the posterior mandrel 1400 is flipped upside down (e.g., by the rotary actuator 1364 operably coupled to the gripper arm 1360).The strength of the vacuum can be controlled to reliably hold the posterior component 1408 against the flipped posterior mandrel 1400 without damaging the posterior component 1408. Also, the vanes 1418 can help prevent excessive deformation of the posterior component 1408 while the vacuum suction force is applied.

[0093] FIGS. 15A and 15B are perspective and cutaway perspective views, respectively, of an anterior mandrel 1500 configured in accordance with embodiments of the present technology. The anterior mandrel 1500 includes a base portion 1515, a stem portion 1510 coupled to and extending from the base portion 1515, and an upper wall 1514 extending circumferentially to restrict movement of an anterior component 1506 mounted on the anterior mandrel 1500.

[0094] Referring first to FIG. 15 A, the base 1515 can be relatively wide and heavy to ensure that the anterior mandrel 1500 remains upright when on a surface (e.g., on the second platform 1224). The stem portion 1510 can be relatively narrow to allow a gripper (e.g., the gripper 1212, the gripper arm 1360) to easily and reliably engage the stem portion 1510. In the illustrated embodiment, the stem portion 1510 includes six flat surfaces that can help the gripper better engage the stem portion 1510. The inner diameter of the upper wall 1514 can be sized to avoid deforming (or excessively deforming) the anterior component 1506. The anterior component 1506 can include three notches 1507a and three elongate rim portions1507b extending between the three notches 1507a. The shaded portion along the top of the anterior component 1506 can define a target area for adhesive application.

[0095] Referring next to FIG. 15B, the anterior mandrel 1500 includes a through hole or interior channel 1520 that is open to the external environment. In the illustrated embodiment, the anterior component 1506 is positioned on a supporting surface 1516 that includes an aperture connected to the interior channel 1520.

[0096] In operation, the anterior mandrel 1500 can keep the anterior component 1506 fixed in position during an attachment process in which the posterior mandrel 1400, oriented upside down, brings the posterior component 1408 to the anterior component 1506. Once the anterior component 1506 and the posterior component 1408 are properly bonded to form a base lens structure, a laser source (not shown) positioned below the anterior mandrel 1500 can emit a laser through the interior channel 1520 and the base lens structure. A camera on the other side of the base lens structure can receive the laser, and the received image can be used to calculate the optical power of the base lens structure. For example, after the attachment process, the same anterior mandrel 1500 can be used during a filling process in which the base lens structure, which can remain mounted on the anterior mandrel 1500, is filled with a fluid (e.g., oil) and the laser is used to track the optical pow er of the base lens structure. In some embodiments, each of the posterior mandrel 1400 and the anterior mandrel 1500 is composed of metal (e.g.. stainless steel), a polymer (e.g., polyether ether ketone (PEEK)), or another suitable material. For example, each of the posterior mandrel 1400 and the anterior mandrel 1500 can include carbon-filled PEEK.

[0097] FIGS. 16 A- 18 illustrate posterior mandrels configured in accordance with various embodiments of the present technology. More specifically, FIGS. 16A and 16B are perspective and cutaway perspective views of a posterior mandrel 1600, respectively; FIGS. 17A and 17B are perspective and cutaway perspective views of a posterior mandrel 1700. respectively; and FIG. 18 is a perspective view of a posterior mandrel 1800.

[0098] Referring first to FIGS. 16A and 16B, the posterior mandrel 1600 includes a stem portion 1 10 and a plurality7of protrusions 1614 that support a posterior component 1608 thereon. The stem portion 1610 defines an interior channel 1620 that opens to the external environment at the aperture 1622. The posterior mandrel 1600 also includes a rim 1616 with a plurality of bumps 1632 that define a plurality of slots 1634 when the posterior component 1 08 is mounted on the rim 1616 and the protrusions 1614. In operation, a vacuum source can apply a vacuum suction force to the posterior component 1608 through the interiorchannel 1620 and the aperture 1622. The slots 1634 can permit airflow to avoid an excessive vacuum suction force that may damage the posterior component 1608.

[0099] Referring next to FIGS. 17A and 17B, the posterior mandrel 1700 includes a stem portion 1710 and a plurality of protrusions 1714 that support a posterior component 1708 thereon. The step portion 1710 defines an interior channel 1720 that opens to the external environment through a plurality of slots 1722. The posterior mandrel 1700 also includes a rim 1716 with a plurality of apertures 1724 that are positioned to interface a bottom periphery of the posterior component 1708 fluidly connected to the slots 1722 and the interior channel 1720, as shown in FIG. 17B. The posterior mandrel 1700 further includes a top surface 1715 with a plurality' of open slots 1732 that are fluidly connected to corresponding ones of a plurality' of apertures 1730 on each of the protrusions 1714. In operation, the slots 1722 can be sealed (e.g., using glue or another suitable sealing material) and a vacuum source can apply a vacuum suction force to the posterior component 1708 through the interior channel 1720 and the plurality of apertures 1724 along the rim 1716. The open slots 1732 and the apertures 1730 can serve as vents to avoid creating a vacuum in the space between the posterior component 1708 and the top surface 1715.

[0100] Referring next to FIG. 18, the posterior mandrel 1800 includes a stem portion 1810 and a plurality of protrusions 1814 that support a posterior component (not shown) thereon. Each of the protrusions 1814 can include rim segments 1816 having a plurality of apertures 1832 and a side slot 1830. The apertures 1832 can be fluidly connected to the corresponding side slot 1830 on the same protrusion 1814 such that, in operation, one or more vacuum sources can be connected to each of the side slots 1830 to apply a vacuum suction force on the posterior component through the apertures 1832 along the rim segments 1816.

[0101] FIGS. 19A and 19B are top camera and perspective views, respectively, of an attachment process at a misaligned stage in accordance with various embodiments of the present technology. In some embodiments, FIG. 19A can represent the image captured by the top view camera 1232 and FIG. 19B can illustrate the posterior mandrel 1400 and the anterior mandrel 1500 as operated by the attachment system 1200. It will be appreciated that the posterior mandrel 1400 can be replaced by the posterior mandrel 1600, the posterior mandrel 1700, the posterior mandrel 1800, and / or other suitable mandrels configured in accordance with the present technology.

[0102] As shown in FIG. 19B, the anterior mandrel 1500 is positioned on amount 1900, and the posterior mandrel 1400 is held above the anterior mandrel 1500 (e.g., by the roboticarm 1210 (not shown in FIG. 19B) such that the posterior component 1408 and the anterior component 1506 are spaced apart and not yet attached together. The posterior component 1408 can remain attached to the posterior mandrel 1400 by a controlled vacuum suction force, as described above. The top view (FIG. 19A) can be used to ensure that the centers of the anterior component 1506 and the posterior component 1408 are aligned. Also, as seen in the top view of FIG. 19A, the protrusions 1414 of the posterior mandrel 1400 are positioned relative to the posterior component 1408 such that each of the notches 1409a are visible. Also, because the anterior component 1506 and the posterior component 1408 are not rotationally aligned, parts of the anterior component 1506 are also visible. To properly align the anterior component 1506 with the posterior component 1408, the posterior mandrel 1400 can be rotated (e.g., by the robotic arm 1210) until, for example, the notches 1409a of the posterior component 1408 align with the notches 1507a (partially obscured from view in FIG. 19A) of the anterior component 1506.

[0103] FIGS. 20A and 20B are top camera and perspective views, respectively, of the attachment process at an aligned stage in accordance with various embodiments of the present technology. In the embodiments illustrated in FIGS. 20A and 20B (as seen by comparing FIGS. 20A and 20B to FIGS. 19A and 19B), the posterior mandrel 1400 has been rotated such that the notches 1409a align with the notches 1507a as seen in the top view (FIG. 20A). The anterior component 1506 and the posterior component 1408, now properly aligned, are ready to be attached together.

[0104] FIGS. 21A and 21B are enlarged perspective and perspective views, respectively, of the attachment process at an attachment stage in accordance with various embodiments of the present technology. As shown, the posterior mandrel 1400 has been moved vertically down (e.g., by the robotic arm 1210) until the anterior component 1506 and the posterior component 1408 are in contact. The adhesives 2100 on one or both of the anterior component 1506 and the posterior component 1408 may spread upon the compressive force applied by the posterior mandrel 1400 and form the bond. In some embodiments, the posterior mandrel 1400 can be moved horizontally (e.g., in a back-and- forth manner) to better distribute the adhesives 2100. In some embodiments, the adhesives 2100 have relatively low viscosity' to facilitate self-alignment of the adhesives 2100. In other embodiments, additives such as fumed silica is added to increase the viscosity of the adhesives 2100.

[0105] While the posterior mandrel 1400 is moved downward, the top camera view can continue to be used to ensure that the anterior component 1506 and the posterior component 1408 remain rotationally and axially aligned. Furthermore, one or more side view cameras (e.g., the first side view camera 1234, the second side view camera 1236, and the third side view camera 1238) can be used to ensure that (i) the anterior component 1506 and the posterior component 1408 remain parallel to one another during the attachment process, (ii) the posterior component 1408 is moved downward against the anterior component 1506 by an appropriate distance, and (iii) the adhesives 2100 are properly spreading and / or coalescing.

[0106] FIG. 22 is a perspective view of the attachment process at a final stage in accordance with various embodiments of the present technology. The posterior component 1408 can be detached from the posterior mandrel 1400 by terminating the vacuum suction force, and the posterior mandrel 1400 can be moved away (e.g., by the robotic arm 1210) to leave the bonded posterior component 1408 and anterior component 1506 on the anterior mandrel 1500, which may remain on the mount 1900. The bonded posterior component 1408 and anterior component 1506 can then be subjected to additional processes to, for example, cure the adhesives 2100 (e.g., using UV light, using heat). In some embodiments, the bonded posterior component 1408 and anterior component 1506 remain in the anterior mandrel 1500 as they next undergo a filling process for achieving a desired optical power.

[0107] FIGS. 23A and 23B are perspective views of a posterior mandrel 2300 configured in accordance with embodiments of the present technology. The posterior mandrel 2300 can include a stem portion 2310 and an upper portion 2314 for receiving and securing a posterior component 2308 thereon. For example, the upper portion 2314 can include a stepped surface 2316 for engaging the different parts of the posterior component 2308. The posterior component can include three notches 2309a and three elongate rim portions 2309b.

[0108] FIGS. 24A and 24B are perspective views of an anterior mandrel 2400 configured in accordance with embodiments of the present technology. The anterior mandrel 2400 can include a stem portion 2410, an upper lip portion 2412, a lower lip portion 2414, and a disc portion 2416 having an aperture 2420. The disc portion 2416 can be sized to loosely receive an anterior component 2406 while still restricting horizontal movement thereof. By sizing the disc portion 2416 to loosely receive the anterior component 2406, the disc portion 2416 can avoid stretching or otherwise deforming the anterior component 2406, which may affect its ultimate optical power. The aperture 2420 can be fluidly connected to an aperture 2422 (better illustrated in FIGS. 25 and 26) at the bottom of the stem portion 2410 to definean interior channel extending therethrough. The anterior component 2406 can include three notches 2407a and three elongate rim portions 2407b.

[0109] FIGS. 25-28 illustrate an attachment process at various stages in accordance with embodiments of the present technology. FIG. 25 illustrates the anterior mandrel 2400 flipped upside down and held above the posterior mandrel 2300 such that the anterior component 2406 and the posterior component 2308 do not yet contact one another. A vacuum source (not shown) can be coupled to the aperture 2422 to apply a vacuum suction force to the anterior component 2406 to keep the anterior component 2406 adhered to the anterior mandrel 2400. FIG. 26 illustrates the anterior mandrel 2400 having moved downward such that the anterior component 2406 contacts and mates with the posterior component 2308. The adhesives applied on one or both of the anterior component 2406 and the posterior component 2308 can then spread and / or coalesce to form the bond.

[0110] FIG. 27 illustrates a top view during the attachment process. As discussed above with respect to FIGS. 19A and 20 A, the top view can be used to ensure that the anterior component 2406 and the posterior component 2308 remain axially and rotationally aligned during the attachment process. For example, the top view can be used to confirm that the notches 2407a are aligned with the notches 2309a before the anterior component 2406 and the posterior component 2308 are bonded together. Notably, the upper lip portion 2412 and the low er lip portion 2414 are each sized to be no greater than the diameter of the anterior component 2406 at the notches 2309a such that the notches 2309a remain visible from the top view.[OHl] FIG. 28 illustrates the bonded anterior component 2406 and posterior component 2308 mounted on the posterior mandrel 2300 and the anterior mandrel 2400 removed from view. As similarly discussed above with reference to FIG. 22, the bonded anterior component 2406 and posterior component 2308 can remain on the same anterior mandrel 2400 when undergoing a filling process. In contrast to FIGS. 19A-22, FIGS. 25-28 illustrate an attachment process in which the posterior component remains fixed in position at the bottom and the anterior component is flipped upside down, held in place by a vacuum suction force, and moved down toward the posterior component.

[0112] FIGS. 29-30B illustrate an optional post-attachment process at various stages in accordance with embodiments of the present technology. In particular. FIG. 29 is a perspective view of a w eighted fixture 2900 held above the posterior mandrel 2300, and FIGS .30A and 30B are perspective and side views of the weighted fixture 2900 resting atop the upper portion 2314.

[0113] Referring first to FIG. 29, the weighted fixture 2900 includes a stem portion 2910 that can be held (e.g., by the robotic arm 1210). In other embodiments, the weighted fixture 2900 can include a generally flat top surface onto which a vacuum suction force can be applied to lift the weighted fixture 2900. The alignment fixture 2900 can include a lower cavity 2920 sized to receive the bonded anterior component 2406 and posterior component 2308.

[0114] Referring next to FIGS. 30A and 30B, the lower cavity 2920 can be dimensioned to be wider than the bonded anterior component 2406 and posterior component 2308 such that the weighted fixture 2900 does not alter the alignment therebetween. However, the height of the lower cavity 2920 can be selected such that when the weighted fixture 2900 rests atop the upper portion 2314 of the posterior mandrel 2300, an upper surface 3030 of the lower cavity 2920 presses against the bonded anterior component 2406 and posterior component 2308. Thus, the height of the lower cavity 2920 can be selected to define a bond gap thickness and uniformity7. The weighted fixture 2900 can also help prevent movement of the bonded anterior component 2406 and posterior component 2308 while the adhesive cures. The weighted fixture 2900 can be composed of polycarbonate, acrylic, or other transparent or translucent material to allow viewing of the bonded anterior component 2406 and posterior component 2308. The weighted fixture 2900 can include one or more slots 3020 that can serve as vent holes for air to flow out therethrough while the weighted fixture 2900 is lowered onto the posterior mandrel 2300.

[0115] FIGS. 31A-31C illustrate an anterior mandrel 3100 configured in accordance with embodiments of the present technology. More specifically, FIG. 31A is a perspective view of the anterior mandrel 3100. and FIGS. 31B and 31C are cutaway perspective view s of the anterior mandrel 3100 cut along two different planes.

[0116] Referring first to FIG. 31A, the anterior mandrel 3100 includes a stem portion 3110, an upper lip portion 3111a, a lower lip portion 3111b, and a separate header portion 3120. The header portion 3120 can support an anterior component 3106 mounted thereon. The header portion 3120 can be fixedly or removably coupled to the stem portion 3110 via fasteners, adhesives, welding, or other suitable coupling mechanisms. The stem portion 3110 can include a flat surface portion 3112 and a vacuum hole 3114 on the flat surface portion 3112. The header portion 3120 can include a plurality of side apertures 3122 along a sidesurface of the header portion 3120 and a plurality of top apertures 3124 along a top surface of the header portion 3120. Each of the top apertures 3124 can have a diameter of about 0. 1 mm, 0.2 mm, 0.3 mm, or 0. 1-0.3 mm. The number of the top apertures 3124 can be between 2-20, between 4-16, or another number.

[0117] Referring next to FIG. 3 IB, the stem portion 31 10 defines an interior channel 3130 fluidly connected to the vacuum hole 3114. The side apertures 3122 are not fluidly connected to the interior channel 3130, but instead are connected to a cylindrical volume of space over which the anterior component 3106 sits. Referring next to FIG. 31C, the interior channel 3130 is fluidly connected to the top apertures 3125. In operation, a vacuum source can be connected to the vacuum hole 3114 to apply a vacuum suction force to the anterior component 3106 through the interior channel 3130 and the top apertures 3124. The side apertures 3122 can serve as vent holes that help avoid creating a vacuum in the cylindrical volume while applying the vacuum suction force on the anterior component 3106.

[0118] FIG. 32 is a perspective view of a suction component 3200 configured in accordance with embodiments of the present technology. The suction component 3200 can include a flexible portion 3210, a stopper portion 3220, and a threaded portion 3230. The flexible portion 3210 can be sized and flexible enough to engage the vacuum hole 3114. In some embodiments, the diameter of the contact region of the flexible portion 3210 is about 1 mm, 1.5 mm, 2 mm. 2.5 mm, 3 mm. or 1-3 mm.

[0119] FIG. 33 is a top view of a gripper arm 3300 configured in accordance with embodiments of the present technology. The gripper arm 3300 can be an example of the gripper arm 1360 illustrated in FIG. 13. The gripper arm 3300 can include a body portion 3310, a central protrusion 3320 extending from the body portion 3310, and a first arm 3330a and a second arm 3330b extending from the body portion 3310. The body portion 3310 can include an aperture 3312 for receiving an actuator (e.g., the rotary actuator 1364). The central protrusion 3320 can include an open cavity 3324 at a distal end and an aperture 3322 providing access to the open cavity 3324. In some embodiments, the open cavity 3324 includes threads to receive the threaded portion 3230 of the suction component 3200. The first arm 3330a and the second arm 3330b can include a first clamping portion 3332a and a second clamping portion 3332b at their distal ends, respectively. Each of the first clamping portion 3332a and the second clamping portion 3332b can include a curvature corresponding to the stem portion 3110 of the anterior mandrel 3100. In some embodiments, the gripper arm 3300 is composed of metal (e.g.. stainless steel), a polymer (e.g., polyether ether ketone(PEEK)), or another suitable material. In some embodiments, the gripper arm 3300 is manufactured via wire EDM or other suitable manufacturing methods.

[0120] FIG. 34 is a perspective view of the gripper arm 3300 gripping the anterior mandrel 3100 configured in accordance with embodiments of the present technology. As shown, the first clamping portion 3332a and the second clamping portion 3332b clamp onto the stem portion 3110 of the anterior mandrel 3100. Also, the suction component 3200 is positioned between the anterior mandrel 3100 and the central protrusion 3320. More specifically, the flexible portion 3210 can be positioned against the flat surface portion 3112 and / or fitted at least partially in the vacuum hole 3114, and the threaded portion 3230 is screwed into the open cavity 3324 of the central protrusion 3320. The stopper portion 3220 can define the final position of the suction component 3200 relative to the central protrusion 3320. A vacuum source 3400 can be coupled to the aperture 3322 to apply a vacuum suction force on the anterior component 3106 through the open cavity 3324, the interior channel 3130. and the apertures 3124 (FIG. 3C). A rotary actuator 3420 (shown schematically) can be operably coupled to the aperture 3312 of the body portion 3310.

[0121] In operation, the gripper arm 3300 can be used to lift, move, rotate, and release the anterior mandrel 3100 (or a different mandrel). Referring back to FIG. 33, the first clamping portion 3332a and the second clamping portion 3332b each has a slanted inner edge at the ven- distal end. Therefore, while the anterior mandrel 3100 is positioned in. for example, a hole in one of the trays 1362 (FIG. 13), the gripper arm 3300 can be moved horizontally toward the stem portion 3110 and the reaction force from the tray 1362 can be enough to spread open the first arm 3330a and the second arm 3330b until the anterior mandrel 3100 is positioned between the first clamping portion 3332a and the second clamping portion 3332b. The first arm 3330a and the second arm 3330b can have a stiffness to allow the first arm 3330a and the second arm 3330b to spread apart and return back to clamp the anterior mandrel 3100.

[0122] The gripper arm 3300 can then be lifted to raise the anterior mandrel 3100 by the upper lip portion 3111a. Before rotating the anterior mandrel 3100, a vacuum source 3410 (shown schematically) can be operably coupled to the aperture 3322 and activated to apply the vacuum suction force on the anterior component 3106. The rotary actuator 3420 can then be activated to rotate the gripper arm 3300, and thus the anterior mandrel 3100 and the anterior component 3106 by 180 degrees, such that the first clamping portion 3332a and the second clamping portion 3332b lift the anterior mandrel 3100 by the lower lip portion 3111b.

[0123] FIG. 35 is a top view of another gripper arm 3500 configured in accordance with embodiments of the present technology. As shown, the gripper arm 3500 can be generally similar to the gripper arm 3300, including a body portion 3510, a central protrusion 3520, a first arm 3530a, and a second arm 3530b. The first arm 3530a and the second arm 3530b can include a first clamping portion 3532a and a second clamping portion 3532b, respectively. The central protrusion can include an aperture 3522 for connecting to a vacuum source and can receive the suction component 3200. However, unlike the arms 3330a, 3330b of the gripper arm 3300, the arms 3530a, 3530b are biased inwards, as shown. The central protrusion 3520 also includes one or more grooves 3540.

[0124] FIG. 36 is a cross-sectional view of yet another gripper arm 3600 configured in accordance with embodiments of the present technology. As shown, the gripper arm 3600 can be generally similar to the gripper arm 3500, including a body portion 3610, a central protrusion 3620, and a first arm 3630a and a second arm 3630b that are biased inwards. The first arm 3630a and the second arm 3630b can include a first clamping portion 3632a and a second clamping portion 3632b, respectively. The central protrusion can include one or more grooves 3640.

[0125] The first clamping portion 3632a and the second clamping portion 3632b are shown engaging the anterior mandrel 3100. Additionally, one or more shims 3602 are positioned in the one or more grooves 3640 of the central protrusion 3620. The shims 3602 can be positioned to push the arms 3630a, 3630b outward against their biases, and can limit or reduce any error in the position of the anterior mandrel 3100 between the first clamping portion 3632a and the second clamping portion 3632b. In some embodiments, the shims 3602 are composed of metal (e.g., stainless steel), a polymer (e.g., poly ether ether ketone (PEEK)), or another suitable material.

[0126] FIG. 37 is a perspective view of an anterior mandrel 3700 configured in accordance with embodiments of the present technology. The anterior mandrel 3700 can include a rotary stage 3710 and a part nest or base holder 3720 removably couplable to the rotary' stage 3710. More specifically, the base holder 3720 can be positioned on top of the rotary stage 3710, and an anterior component 3706 (e.g., the anterior component 106) can be mounted on top of the base holder 3720. As discussed in further detail herein, each of the rotary stage 3710 and the base holder 3720 can include features that allow the rotary stage 3710 and the base holder 3720 to be removably coupled to and properly aligned with one another. Also, the base holder 3720 can include features to securely hold the anteriorcomponent 3706 thereon so that, e.g., the base holder 3720 can be moved to another location while holding the anterior component 3706.

[0127] FIG. 38 is a perspective view of the rotary stage 3710. In the illustrated embodiment, the rotary stage 3710 has a cylindrical body with a first boss 3812, one or more recesses 3814, and one or more second bosses 3816. The first boss 3812 can protrude or extend from the center of a top surface of the cylindrical body. The first boss 3812 can have a cylindrical form factor (as shown) or other shapes and / or sizes. The second bosses 3816 can protrude or extend from the top surface of the cylindrical body, and can be arranged around the first boss 3812. The second bosses 3816 can have a hemi-spherical form factor (as shown) or other suitable shapes and / or sizes. The recesses 3814 can extend into the cylindrical body from the top surface, and can be arranged around the first boss 3812. The recesses 3814 can have a circular cross-section (as shown) or other suitable shapes and / or sizes. In some embodiments, the recesses 3814 can receive magnets (not shown) therein.

[0128] FIG. 38 also illustrates a plurality of lines of sight 3801 of a plurality of cameras (not shown) that can be arranged around the anterior mandrel 3700. For example, one line of sight 3801 extends vertically down towards the first boss 3812 and the anterior component 3706, and three lines of sight 3801 extend laterally from various directions towards the anterior component 3706. In operation, the cameras can be used to ensure that the rotary stage 3710, the base holder 3720, and / or the anterior component 3706 are properly aligned.

[0129] FIGS. 39A and 39B are perspective top and bottom views, respectively, of the base holder 3720. Referring to FIGS. 39A and 39B together, the base holder 3720 has a body with an aperture 3922, one or more recesses 3924, one or more grooves 3926, and one or more bosses 3928. The aperture 3922 can include a through-hole extending through the center of the body, and can be shaped and sized to receive the first boss 3812 of the rotary stage 3710. For example, in the illustrated embodiment, the aperture 3922 has a circular crosssection to match the cylindrical form factor of the first boss 3812 illustrated in FIG. 38. In other embodiments, the aperture 3922 can have other shapes and / or sizes. The body of the base holder 3720 can also have one or more flat sides 3925 that can facilitate gripping of the base holder 3720.

[0130] As best seen in FIG. 39B, the recesses 3924 can extend into the body from a bottom surface of the body, and can be arranged around the aperture 3922. The recesses 3924 can have a circular cross-section (as shown) or other shapes and / or sizes. In some embodiments, the recesses 3924 can receive magnets (not shown) therein. The grooves 3926can extend along the bottom surface of the body and radially outward from the aperture 3922. The grooves 3926 can be V-shaped (as shown) or can have other shapes and / or sizes.

[0131] As best seen in FIG. 39A, the bosses 3928 can protrude or extend from the top surface of the body, and can be arranged around the aperture 3922. The bosses 3928 can be shaped, sized, and arranged to hold the anterior component 3706. Tn some embodiments, the bosses 3928 can mate loosely to the internal docking area of the anterior component 3706 intended for a lens (e.g., the slots 112 shown in FIGS. IB and 1C) for angular alignment.

[0132] In operation, referring to FIGS. 37-39B together, the first boss 3812 of the rotary' stage 3710 can fit into the aperture 3922 of the base holder 3720, the magnets in the recesses 3814 of the rotary stage 3710 can electromagnetically align with corresponding ones of the magnets in the recesses 3924 of the base holder 3720, and the second bosses 3816 of the rotary stage 3710 can fit into corresponding ones of the grooves 3926 of the base holder 3720. The anterior component 3706 can be secured to the base holder 3720 (e.g., via the bosses 3928 of the base holder 3720) before, while, or after coupling and aligning the rotary stage 3710 and the base holder 3720. The bosses 3928 can provide angular alignment with and prevent (or at least reduce) movement of the anterior component 3906. In some embodiments, the bosses 3928 are also expected to help prevent distortion of the anterior component 3906 during, e.g., high-temperature curing.

[0133] Therefore, the rotary' stage 3710, the base holder 3720, and / or the anterior component 3706 can be accurately and repeatably aligned and secured together using kinematic and / or magnetic mates. Furthermore, as discussed above with reference to FIG. 38, a plurality of cameras arranged around the anterior mandrel 3700 can be used to further facilitate and ensure proper alignment of the parts.

[0134] Any of the features of the AIOL manufacturing systems and methods described herein may be combined with any of the features of the other AIOL manufacturing systems and methods described herein and vice versa. For example, features described with respect to a posterior mandrel can be included in an anterior mandrel, and vice versa. Mandrels configured in accordance with embodiments of the present technology' can have curvatures that match or otherwise correspond to curvatures of an AIOL base (or component thereof). The mandrels described herein can hold and support components of an AIOL base (e.g., an anterior component, a posterior component) in their natural shape so that, upon mating, the mandrels do not distort (or at least reduce distortion of) the AIOL components from their natural shape. In some cases, the curvature of optical membranes in am AIOL base can bemanufactured into thee mandrel. Additionally, several specific examples of embodiments in accordance with the present technology are set forth below in the following examples.Examples

[0135] The present technology is illustrated, for example, according to various aspects described below as numbered examples (1, 2, 3, etc.) for convenience. These are provided as examples and do not limit the present technology. It is noted that any of the dependent examples may be combined in any combination, and placed into a respective independent example. The other examples can be presented in a similar manner.1. A self-aligning fixture assembly for manufacturing an accommodating intraocular lens (AIOL), the assembly comprising: a first component holder configured to hold a first component of an AIOL base; a second component holder configured to hold a second component of the AIOL base, wherein the second component holder includes at least one alignment feature configured to align the first component with the second component; and an actuator operably coupled to the first component holder and configured to move the first component holder toward and / or away from the second component holder.2. The assembly of example 1 wherein the first component holder includes at least one tab configured to fit into at least one corresponding slot included in the first component of the AIOL base, and wherein the at least one tab is configured to removably secure the first component of the AIOL base to the first component holder.3. The assembly of example 1 or example 2 wherein the at least one alignment feature comprises a protrusion having a curvature corresponding to an outer side curvature of the first component and to an outer side curvature of the second component, and wherein the at least one alignment feature has a dimension sized such that the alignment feature contacts both the first and second components of the AIOL base when the first and second components of the AIOL base are engaged with one another by the actuator.4. The assembly of any one of examples 1-3 wherein the first component comprises an anterior component of the AIOL base, and wherein the second component comprises a posterior component of the AIOL base.5. A method for aligning an anterior component and a posterior component of an accommodating intraocular lens (AIOL) base, the method comprising: applying an adhesive material to a first alignment tab extending radially from the anterior component and to a second alignment tab extending radially from the posterior component, wherein the first alignment tab includes a pin, and wherein the second alignment tab includes an aperture configured to receive the pin; engaging the anterior component with the posterior component such that the first alignment tab interfaces the second alignment tab; inserting the engaged anterior and posterior components in an alignment structure, wherein the alignment structure includes a recess configured to receive the first and second alignment tabs; after curing of the adhesive material, removing the engaged anterior and posterior components from the alignment structure; and removing the first and second alignment tabs from the anterior and posterior components.6. The method of example 5 wherein the first and second alignment tabs are dimensioned such that when the first and second alignment tabs are interfacing, a gap configured to receive the adhesive material remains between the anterior and posterior components.7. An automated alignment system for manufacturing an accommodating intraocular lens (AIOL). the system comprising: a rotational stage configured to rotationally move an AIOL component; a first linear stage configured to cany7the rotational stage along a first axis; a second linear stage configured to carry the rotational stage about a second axis; an adhesive applicator configured to apply an adhesive to the AIOL component; a camera positioned to view the AIOL component; anda controller configured to control the rotational stage, the first linear stage, the second linear stage, and the adhesive applicator based on an adhesive application plan.8. The system of example 7, further comprising a processor configured to: receive image data from the camera; input the received image data into an artificial intelligence or machine learning model, wherein the model is trained to output an adhesive application score; and based on the received image data, adjust the adhesive application plan.9. An attachment system for manufacturing an accommodating intraocular lens (AIOL), the system comprising: a first mandrel sized and shaped to releasably support a first component of an AIOL base; a second mandrel sized and shaped to releasably support a second component of the AIOL base, wherein the second mandrel includes a vacuum hole and a plurality of apertures in fluid connection with the vacuum hole and positioned to interface the second component of the AIOL base; a gripper configured to grip the second mandrel; an actuator operably coupled to the gripper and configured to move and rotate the gripper; and a vacuum source operably coupled to the vacuum hole and configured to apply a vacuum suction force on the second component of the AIOL base through the plurality’ of apertures.10. The system of example 9 wherein the first mandrel includes a through hole extending from a top surface of the first mandrel supporting the first component of the AIOL base to a bottom surface of the first mandrel.11. The system of example 9 or example 10 wherein the second component of the AIOL base includes a plurality' of notches, wherein the second mandrel includes a plurality of protrusions extending radially outward and upward to engage side portions of the second component of the AIOL base away from the plurality of notches.12. The system of any one of examples 9-11. further comprising a weighted fixture having a lower cavity sized to receive the first and second components of the AIOL base, wherein the weighted fixture is configured to compress the first and second components of the AIOL base against the first mandrel, and wherein the weighted fixture is at least partially transparent.13. The system of any one of examples 9-12, wherein the gripper includes a body portion configured to couple to the actuator, a central protrusion extending from the body portion, a first arm extending from the body portion, and a second arm extending from the body portion, and wherein the first and second arms have a first clamping portion and a second clamping portion, respectively, configured to grip the second mandrel.14. The system of example 13, wherein the central protrusion includes an open cavity and an aperture connected to the open cavity, wherein the aperture is configure to operably couple to the vacuum source, and wherein the system further comprises a suction component positioned between the vacuum hole of the second mandrel and the open cavity.15. A method for aligning and attaching a first component and a second component of an accommodating intraocular lens (AIOL) base, the method comprising: positioning a first component of an AIOL base on a first mandrel; positioning a second component of the AIOL base on a second mandrel; applying an adhesive to at least one of an anterior component or a posterior component of an AIOL base; applying a vacuum suction force to the second component through one or more apertures on the second mandrel; orienting the second mandrel in an upside down orientation such that the second components adheres to the second mandrel due to the vacuum suction force; moving the second mandrel towards the first mandrel such that the first and second components bond together with the adhesive.16. The method of example 15, further comprising: detecting, using a top view camera, an angular misalignment between the first and second components; androtating the second mandrel about a vertical axis to correct the detected angular misalignment.17. The method of example 15 or example 16, further comprising: detecting, using a top view camera, a positional misalignment between the first and second components; and translating the second mandrel along one or more horizontal axes to correct the detected positional misalignment.18. The method of any one of examples 15-17 wherein the first component comprises an anterior component, and wherein the second component comprises a posterior component.19. The method of any one of examples 15-18 wherein the first component comprises a posterior component, and wherein the second component comprises an anterior component.20. A self-aligning fixture assembly for manufacturing an accommodating intraocular lens (AIOL) base, the assembly comprising: a first component holder configured to hold a first component of an AIOL base; a second component holder configured to hold a second component of the AIOL base, wherein the second component holder includes an alignment feature configured to align the first component with the second component; and an actuator operably coupled to at least one of the first component holder or the second component holder, wherein the actuator is configured to move the at least one of the first component holder or the second component holder.21. The assembly of example 20 wherein the alignment feature includes a plurality of bosses shaped and positioned to interface corresponding ones of first external grooves of the first component and corresponding ones of second external grooves of the second component.22. The assembly of example 20 or example 21 wherein the alignment feature includes a vertical dimension that defines a minimum thickness of the AIOL base that a weight can compress the AIOL base to.23. The assembly of any one of examples 20-22 wherein the alignment feature includes a recess in the second component holder, wherein the recess is positioned, shaped, and sized to at least partially receive a first alignment tab of the first component and a second alignment tab of the second component.24. The assembly of example 23 wherein the alignment feature further includes a hole positioned, shaped, and sized to at least partially receive a pin extending through the first alignment tab and the second alignment tab.25. The assembly of any one of examples 20-24 wherein the first component holder includes a plurality of tabs shaped and sized to fit in interior slots of the first component.26. The assembly of any one of examples 20-25 wherein the second component holder includes a recess configured to receive the second component, and wherein the alignment feature is positioned adjacent to or around the recess.27. The assembly of any one of examples 20-26 wherein at least one of the first component holder or the second component holder includes a channel extending at least partially therethrough, and wherein the channel is configured to be coupled to a vacuum source so that a vacuum suction force applied by the vacuum source can keep the first component or the second component adhered to the first component holder or the second component holder.28. The assembly of example 27 wherein the at least one of the first component holder or the second component holder includes a plurality of vanes positioned at a distal end of the channel.29. The assembly of example 27 or example 28 wherein the at least one of the first component holder or the second component holder includes a rim configured to contact thefirst component or the second component, wherein the rim includes a plurality' of bumps defining a plurality of slots therebetween and through which air can flow into the channel.30. The assembly of any one of examples 27-29 wherein the at least one of the first component holder or the second component holder includes a plurality of apertures (a) positioned to interface a bottom periphery of the first component or the second component and (b) in fluid communication with the channel.31. The assembly of any one of examples 27-30 wherein the at least one of the first component holder or the second component holder includes one or more vents extending from the channel.32. The assembly of any one of examples 27-31 wherein the at least one of the first component holder or the second component holder includes a stem configured to be gripped by a gripper arm, wherein the stem includes a vacuum hole in fluid communication with the channel.33. The assembly of any one of examples 20-32 wherein at least one of the first component holder or the second component holder includes: a rotary stage; and a base holder removably couplable to the rotary stage, wherein the rotary stage includes a central boss and the base holder includes a central hole configured to receive the central boss, and wherein the rotary stage includes a plurality of bosses arranged around the central boss and the base holder includes a plurality of grooves extending radially outward from the central hole and configured to interface corresponding ones of the plurality of bosses.34. The assembly of example 33 wherein the rotary stage includes a plurality of first recesses arranged around the central boss, wherein the base holder includes a plurality of second recessed arranged around the central hole, and wherein the at least one of the first component holder or the second component holder further includes: a first plurality of magnets positioned in corresponding ones of the first recesses; anda second plurality of magnets positioned in corresponding ones of the second recesses, wherein the first plurality of magnets and the second plurality of magnets are configured to angularly align the rotary stage and the base holder.35. The assembly of any one of examples 20-34 wherein the at least one of the first component holder or the second component holder includes one or more vents extending from a top surface of the first component holder or the second component holder.36. The assembly of any one of examples 20-35 wherein the first component includes an anterior component of the AIOL base, and wherein the second component includes a posterior component of the AIOL base.37. An attachment system for manufacturing an accommodating intraocular lens (AIOL) base, the system comprising: a first mandrel sized and shaped to releasably support a first component of an AIOL base; a second mandrel sized and shaped to releasably support a second component of the AIOL base, wherein the second mandrel includes a vacuum hole and at least one aperture in fluid connection with the vacuum hole and positioned to interface the second component of the AIOL base; a gripper configured to grip the second mandrel; an actuator operably coupled to the gripper and configured to move and / or rotate the gripper; and a vacuum source operably coupled to the vacuum hole and configured to apply a vacuum suction force on the second component through the at least one aperture.38. The system of example 37 wherein the gripper includes: a body portion configured to be coupled to the actuator; a first arm extending from the body portion; a second arm extending from the body portion, wherein the first and second arms are configured to grip the second mandrel; and a central protrusion extending from the body portion, wherein the central protrusion includes a channel configured to be coupled to, when the first and second armsgrip the second mandrel, the vacuum source and the vacuum hole of the second mandrel.39. The system of example 37 or example 38, further comprising a suction component configured to be coupled between a channel extending through the gripper and the vacuum hole of the second mandrel, wherein the channel is couplable to the vacuum source.Conclusion

[0136] The above detailed description of embodiments of the technology are not intended to be exhaustive or to limit the technology to the precise form disclosed above. Although specific embodiments of, and examples for, the technology are described above for illustrative purposes, various equivalent modifications are possible within the scope of the technology as those skilled in the relevant art will recognize. For example, any of the features of the fluid-filling systems described herein may be combined with any of the features of the other fluid-filling systems described herein and vice versa. Moreover, although steps are presented in a given order, alternative embodiments may perform steps in a different order. The various embodiments described herein may also be combined to provide further embodiments.

[0137] From the foregoing, it will be appreciated that specific embodiments of the technology have been described herein for purposes of illustration, but well-known structures and functions associated with AIOLs have not been shown or described in detail to avoid unnecessarily obscuring the description of the embodiments of the technology. Where the context permits, singular or plural terms may also include the plural or singular term, respectively.

[0138] Moreover, unless the word "or" is expressly limited to mean only a single item exclusive from the other items in reference to a list of two or more items, then the use of "or" in such a list is to be interpreted as including (a) any single item in the list, (b) all of the items in the list, or (c) any combination of the items in the list. Additionally, the term "comprising" is used throughout to mean including at least the recited feature(s) such that any greater number of the same feature and / or additional types of other features are not precluded. It will also be appreciated that specific embodiments have been described herein for purposes of illustration, but that various modifications may be made without deviating from thetechnology. Further, while advantages associated with some embodiments of the technology have been described in the context of those embodiments, other embodiments may also exhibit such advantages, and not all embodiments need necessarily exhibit such advantages to fall within the scope of the technology. Accordingly, the disclosure and associated technology can encompass other embodiments not expressly shown or described herein.

Claims

CLAIMSI / 'W e claim:

1. A self-aligning fixture assembly for manufacturing an accommodating intraocular lens (AIOL), the assembly comprising: a first component holder configured to hold a first component of an AIOL base; a second component holder configured to hold a second component of the AIOL base, wherein the second component holder includes at least one alignment feature configured to align the first component with the second component; and an actuator operably coupled to the first component holder and configured to move the first component holder toward and / or away from the second component holder.

2. The assembly of claim 1 wherein the first component holder includes at least one tab configured to fit into at least one corresponding slot included in the first component of the AIOL base, and wherein the at least one tab is configured to removably secure the first component of the AIOL base to the first component holder.

3. The assembly of claim 1 wherein the at least one alignment feature comprises a protrusion having a curv ature corresponding to an outer side curvature of the first component and to an outer side curvature of the second component, and wherein the at least one alignment feature has a dimension sized such that the alignment feature contacts both the first and second components of the AIOL base when the first and second components of the AIOL base are engaged with one another by the actuator.

4. The assembly of claim 1 wherein the first component comprises an anterior component of the AIOL base, and wherein the second component comprises a posterior component of the AIOL base.

5. A method for aligning an anterior component and a posterior component of an accommodating intraocular lens (AIOL) base, the method comprising: applying an adhesive material to a first alignment tab extending radially from the anterior component and to a second alignment tab extending radially from theposterior component, wherein the first alignment tab includes a pin, and wherein the second alignment tab includes an aperture configured to receive the pin; engaging the anterior component with the posterior component such that the first alignment tab interfaces the second alignment tab; inserting the engaged anterior and posterior components in an alignment structure, wherein the alignment structure includes a recess configured to receive the first and second alignment tabs; after curing of the adhesive material, removing the engaged anterior and posterior components from the alignment structure; and removing the first and second alignment tabs from the anterior and posterior components.

6. The method of claim 5 wherein the first and second alignment tabs are dimensioned such that when the first and second alignment tabs are interfacing, a gap configured to receive the adhesive material remains between the anterior and posterior components.

7. An automated alignment system for manufacturing an accommodating intraocular lens (AIOL), the system comprising: a rotational stage configured to rotationally move an AIOL component; a first linear stage configured to cany7the rotational stage along a first axis; a second linear stage configured to carry the rotational stage about a second axis; an adhesive applicator configured to apply an adhesive to the AIOL component; a camera positioned to view the AIOL component; and a controller configured to control the rotational stage, the first linear stage, the second linear stage, and the adhesive applicator based on an adhesive application plan.

8. The system of claim 7, further comprising a processor configured to: receive image data from the camera; input the received image data into an artificial intelligence or machine learning model, wherein the model is trained to output an adhesive application score; and based on the received image data, adjust the adhesive application plan.

9. An atachment system for manufacturing an accommodating intraocular lens (AIOL), the system comprising: a first mandrel sized and shaped to releasably support a first component of an AIOL base; a second mandrel sized and shaped to releasably support a second component of the AIOL base, wherein the second mandrel includes a vacuum hole and a plurality of apertures in fluid connection with the vacuum hole and positioned to interface the second component of the AIOL base; a gripper configured to grip the second mandrel; an actuator operably coupled to the gripper and configured to move and rotate the gripper; and a vacuum source operably coupled to the vacuum hole and configured to apply a vacuum suction force on the second component of the AIOL base through the plurality' of apertures.

10. The system of claim 9 wherein the first mandrel includes a through hole extending from a top surface of the first mandrel supporting the first component of the AIOL base to a botom surface of the first mandrel.

11. The system of claim 9, wherein the second component of the AIOL base includes a plurality of notches, wherein the second mandrel includes a plurality of protrusions extending radially outward and upward to engage side portions of the second component of the AIOL base away from the plurality of notches.

12. The system of claim 9, further comprising a weighted fixture having a lower cavity sized to receive the first and second components of the AIOL base, wherein the weighted fixture is configured to compress the first and second components of the AIOL base against the first mandrel, and wherein the weighted fixture is at least partially transparent.

13. The system of claim 9, wherein the gripper includes a body portion configured to couple to the actuator, a central protrusion extending from the body portion, a first arm extending from the body portion, and a second arm extending from the body portion, and wherein the first and second arms have a first clamping portion and a second clamping portion, respectively, configured to grip the second mandrel.

14. The system of claim 13, wherein the central protrusion includes an open cavity and an aperture connected to the open cavity, wherein the aperture is configure to operably couple to the vacuum source, and wherein the system further comprises a suction component positioned between the vacuum hole of the second mandrel and the open cavity.

15. A method for aligning and attaching a first component and a second component of an accommodating intraocular lens (AIOL) base, the method comprising: positioning a first component of an AIOL base on a first mandrel; positioning a second component of the AIOL base on a second mandrel; applying an adhesive to at least one of an anterior component or a posterior component of an AIOL base; applying a vacuum suction force to the second component through one or more apertures on the second mandrel; orienting the second mandrel in an upside down orientation such that the second components adheres to the second mandrel due to the vacuum suction force; moving the second mandrel towards the first mandrel such that the first and second components bond together with the adhesive.

16. The method of claim 15, further comprising: detecting, using a top view camera, an angular misalignment between the first and second components; and rotating the second mandrel about a vertical axis to correct the detected angular misalignment.

17. The method of claim 15, further comprising: detecting, using a top view camera, a positional misalignment between the first and second components; and translating the second mandrel along one or more horizontal axes to correct the detected positional misalignment.

18. The method of claim 15 wherein the first component comprises an anterior component, and wherein the second component comprises a posterior component.

19. The method of claim 15 wherein the first component comprises a posterior component, and wherein the second component comprises an anterior component.

20. A self-aligning fixture assembly for manufacturing an accommodating intraocular lens (AIOL) base, the assembly comprising: a first component holder configured to hold a first component of an AIOL base; a second component holder configured to hold a second component of the AIOL base, wherein the second component holder includes an alignment feature configured to align the first component with the second component; and an actuator operably coupled to at least one of the first component holder or the second component holder, wherein the actuator is configured to move the at least one of the first component holder or the second component holder.

21. The assembly of claim 20 wherein the alignment feature includes a plurality of bosses shaped and positioned to interface corresponding ones of first external grooves of the first component and corresponding ones of second external grooves of the second component.

22. The assembly of claim 20 wherein the alignment feature includes a vertical dimension that defines a minimum thickness of the AIOL base that a weight can compress the AIOL base to.

23. The assembly of claim 20 wherein the alignment feature includes a recess in the second component holder, wherein the recess is positioned, shaped, and sized to at least partially receive a first alignment tab of the first component and a second alignment tab of the second component.

24. The assembly of claim 23 wherein the alignment feature further includes a hole positioned, shaped, and sized to at least partially receive a pin extending through the first alignment tab and the second alignment tab.

25. The assembly of claim 20 wherein the first component holder includes a plurality of tabs shaped and sized to fit in interior slots of the first component.

26. The assembly of claim 20 wherein the second component holder includes a recess configured to receive the second component, and wherein the alignment feature is positioned adjacent to or around the recess.

27. The assembly of claim 20 wherein at least one of the first component holder or the second component holder includes a channel extending at least partially therethrough, and wherein the channel is configured to be coupled to a vacuum source so that a vacuum suction force applied by the vacuum source can keep the first component or the second component adhered to the first component holder or the second component holder.

28. The assembly of claim 27 wherein the at least one of the first component holder or the second component holder includes a plurality of vanes positioned at a distal end of the channel.

29. The assembly of claim 27 wherein the at least one of the first component holder or the second component holder includes a rim configured to contact the first component or the second component, wherein the rim includes a plurality of bumps defining a plurality of slots therebetween and through which air can flow into the channel.

30. The assembly of claim 27 wherein the at least one of the first component holder or the second component holder includes a plurality of apertures (a) positioned to interface a bottom periphery of the first component or the second component and (b) in fluid communication with the channel.

31. The assembly of claim 27 wherein the at least one of the first component holder or the second component holder includes one or more vents extending from the channel.

32. The assembly of claim 27 wherein the at least one of the first component holder or the second component holder includes a stem configured to be gripped by a gripper arm, wherein the stem includes a vacuum hole in fluid communication with the channel.

33. The assembly of claim 20 wherein at least one of the first component holder or the second component holder includes:a rotary stage; and a base holder removably couplable to the rotary stage. wherein the rotary stage includes a central boss and the base holder includes a central hole configured to receive the central boss, and wherein the rotary stage includes a plurality7of bosses arranged around the central boss and the base holder includes a plurality of grooves extending radially outward from the central hole and configured to interface corresponding ones of the plurality of bosses.

34. The assembly of claim 33 wherein the rotary stage includes a plurality of first recesses arranged around the central boss, wherein the base holder includes a plurality of second recessed arranged around the central hole, and wherein the at least one of the first component holder or the second component holder further includes: a first plurality of magnets positioned in corresponding ones of the first recesses; and a second plurality of magnets positioned in corresponding ones of the second recesses. wherein the first plurality of magnets and the second plurality of magnets are configured to angularly align the rotary' stage and the base holder.

35. The assembly of claim 20 wherein the at least one of the first component holder or the second component holder includes one or more vents extending from a top surface of the first component holder or the second component holder.

36. The assembly of claim 20 wherein the first component includes an anterior component of the AIOL base, and wherein the second component includes a posterior component of the AIOL base.

37. An attachment system for manufacturing an accommodating intraocular lens (AIOL) base, the system comprising: a first mandrel sized and shaped to releasably support a first component of an AIOL base; a second mandrel sized and shaped to releasably support a second component of the AIOL base, wherein the second mandrel includes a vacuum hole and at least one aperture in fluid connection with the vacuum hole and positioned to interface the second component of the AIOL base;a gripper configured to grip the second mandrel; an actuator operably coupled to the gripper and configured to move and / or rotate the gripper; and a vacuum source operably coupled to the vacuum hole and configured to apply a vacuum suction force on the second component through the at least one aperture.

38. The system of claim 37 wherein the gripper includes: a body portion configured to be coupled to the actuator; a first arm extending from the body portion; a second arm extending from the body portion, wherein the first and second arms are configured to grip the second mandrel; and a central protrusion extending from the body portion, wherein the central protrusion includes a channel configured to be coupled to, when the first and second arms grip the second mandrel, the vacuum source and the vacuum hole of the second mandrel.

39. The system of claim 37, further comprising a suction component configured to be coupled between a channel extending through the gripper and the vacuum hole of the second mandrel, wherein the channel is couplable to the vacuum source.

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