Implant with bionic Anti-wear texture, and preparation method therefor

Abstract

A preparation method for an implant with a bionic anti-wear texture. The preparation method comprises the following steps: placing on a mobile platform of a femtosecond pulse laser processing system a titanium alloy to be processed, and performing femtosecond pulse laser processing according to a preset bionic texture diagram, so as to obtain an implant with a bionic anti-wear texture. In the preparation method, femtosecond pulse laser light is used to process textured patterns on the surface of a medical titanium alloy, so as to form a bionic texture, such that contamination from impurity ions can be reduced, and splashing and the generation of molten particles are reduced, thereby greatly improving the processing quality of a textured surface; moreover, an undulating bionic texture is designed on the surface of a material on the basis of bionic technology, such that the generation of particles during wearing can be reduced, and wearing particles are captured, thereby improving the stability of the titanium alloy during wearing, and thus reducing the extent of wearing on the surface of the material; and neither a secondary surface treatment after texturing nor other modification techniques are required, thereby improving the wear resistance of an implant.

Description

Implant with bionic anti-friction texture and preparation method thereof

[0001] This application claims priority to the Chinese patent application filed with the China Patent Office on October 24, 2023, with application number 202311385347.8 and invention name “An implant with bionic anti-friction texture and its preparation method”, the entire contents of which are incorporated by reference into this application. Technical Field

[0002] The present invention relates to the technical field of medical materials, and more particularly to an implant with a bionic anti-friction texture and a preparation method thereof. Background Art

[0003] Due to the low hardness and poor fatigue strength of titanium alloys, implants are prone to loosening of fastening screws, pitting and corrosion of connecting threads during service. Furthermore, as titanium alloys are inert metals, they lack the ability to stimulate osteoblast and osteocyte proliferation, relying primarily on mechanical locking with bone for retention. Furthermore, the dense titanium oxide on their surface makes it virtually impossible for implants to induce the deposition of bone-like apatite in simulated body fluids or in vivo, resulting in only general osseointegration with bone tissue, leading to problems such as osseointegration failure and peri-implant bone resorption. More seriously, once implanted in the human body, medical titanium alloys are subject to constant movement and friction with tissues and organs within the body, subjecting them to loads of varying magnitude, direction, and type. This causes friction and wear at the implant-tissue interface. Due to the poor wear resistance of titanium alloys, toxic ions released from wear particles can cause implant failure, inflammation, and toxic effects on the human body, even affecting the normal functioning of other organs. This significantly reduces the reliability, safety, and service life of titanium alloy implant systems, limiting their application. Therefore, how to improve the wear resistance of titanium alloy implants is a key issue in improving their long-term safety, reliability and service stability.

[0004] Currently, the surface modification methods for titanium alloy implants mainly include physical modification (sandblasting, plasma treatment, laser treatment), electrochemical modification (anodization, micro-arc oxidation, sol-gel), chemical modification (alkali heat treatment, acid-base two-step treatment), and bioactive modification (self-assembly technology, biomolecule adsorption, antibacterial coating). However, the traditional sandblasting method has difficulty in obtaining a uniform rough surface of titanium implants and is prone to introducing impurities, which can easily reduce the life of the implant. Plasma spraying can provide a porous implant surface and increase the bone contact area, making it an ideal method for implant surface roughening. However, due to the complex process requirements, it is easy to form an uneven coating, causing problems such as peeling and degradation, and its application in implant modification still has certain limitations. The sol-gel method needs to consider the impact of thermal effects, which limits its clinical use. Laser processing technology does not directly contact the surface of the implant, has low thermal effects, has little impact on the implant surface, has high processing precision, does not introduce foreign impurities, and can remove bacteria on the implant surface. It has attracted widespread attention from researchers, especially selective laser melting (SLM) technology, but titanium alloy implants modified solely by SLM do not have antibacterial properties and still need to be combined with other technologies. Therefore, it is urgent to find a new surface modification method that can not only meet the excellent biocompatibility and antibacterial properties required for the clinical use of titanium alloy implants, but also significantly improve their wear resistance, thereby extending the service life of titanium alloy implants and improving their service safety and stability.

[0005] In summary, the existing technology still has the following shortcomings: during the implantation and service process of titanium alloy implants, friction and wear occur at the implant-biological tissue interface. Due to the poor wear resistance of titanium alloy, toxic ions dissolved in the wear particles can cause implant failure, cause inflammation and toxic effects on the human body, and even affect the normal operation of other organs of the human body, greatly reducing the reliability, safety and service life of the titanium alloy implant system; traditional physical, electrochemical and chemical surface modification technologies often have defects such as complex processes, easy introduction of impurities, unstable processing surface quality, and damage to the material itself.

[0006] Summary of the Invention

[0007] In view of this, the purpose of the present invention is to provide an implant with a bionic wear-reducing texture and a preparation method thereof. The preparation method provided by the present invention uses ultrafast laser technology to achieve good control of the dimensional accuracy and structural integrity of the bionic texture without causing thermal effects on the material itself or introducing other impurities, and combines bionics to prepare a shell-patterned bionic wear-resistant texture on the surface of titanium alloy.

[0008] The present invention provides a method for preparing an implant having a bionic anti-friction texture, comprising the following steps:

[0009] The titanium alloy to be processed is placed on the mobile platform of the femtosecond pulse laser processing system, and femtosecond pulse laser processing is performed according to a pre-set bionic texture pattern to obtain an implant with a bionic wear-reducing texture.

[0010] Preferably, the titanium alloy to be processed is selected from a Ti6Al4V titanium alloy substrate, a Ti5Al2.5Fe titanium alloy substrate and a Ti6Al7Nb titanium alloy substrate.

[0011] Preferably, the titanium alloy to be processed is placed in front of the mobile platform, and further comprises:

[0012] The titanium alloy to be processed is ultrasonically cleaned in ethanol and / or water for 10 minutes to 30 minutes.

[0013] Preferably, the femtosecond pulse laser processing system is composed of a pulse laser, an optical path system, a control system and a mobile platform.

[0014] Preferably, the bionic texture pattern is composed of a plurality of wavy groove textures with anti-friction effect arranged at the same interval; the wavy groove texture is composed of a semicircle with a radius of 0.1mm to 0.3mm, and the interval between two adjacent wavy groove textures is 0.1mm to 0.3mm.

[0015] Preferably, the setting process of the bionic texture pattern is specifically as follows:

[0016] The shell surface texture was observed under microscope light, the shell surface morphology was extracted, the morphology map was designed using AutoCAD, and the wear resistance under different radius and spacing parameters was measured through a rotational friction experiment. The texture size with the radius and spacing parameters that had the best wear resistance was determined; then the texture pattern was saved in the def format, the laserDESK software of the control system in the femtosecond pulse laser processing system was opened, and the texture pattern file in the def format mentioned above was imported to complete the setting of the bionic texture map.

[0017] Preferably, the femtosecond pulse laser processing process is specifically as follows:

[0018] After completing the setting of the bionic texture pattern, set the pulse laser parameters of the femtosecond pulse laser processing system:

[0019] The first step is to set the number of scans and scanning speed of laser processing;

[0020] The second step is to set the laser average power and laser frequency;

[0021] The third step is to adjust the laser position;

[0022] Femtosecond pulse laser processing is then performed to form a wavy groove texture, ultimately obtaining an implant with a bionic wear-reducing texture.

[0023] Preferably, the scanning times are 20 to 40 times, and the scanning speed is 80 mm / s to 120 mm / s;

[0024] The average laser power is 0.3W to 0.5W, and the laser frequency is 0.8kHz to 1.2kHz;

[0025] The laser position is adjusted by adjusting the z-axis position of the mobile platform of the femtosecond pulse laser processing system to be equal to the initial position plus the height of the titanium alloy to be processed.

[0026] Preferably, the beam quality of the femtosecond pulse laser processing is M 2 =1~1.5, the spot diameter in the experiment is 30μm~50μm, the pulse width is 250fs~280fs, and the wavelength is 340nm~350nm.

[0027] The present invention also provides an implant with a bionic anti-friction texture, which is prepared using the preparation method described in the above technical solution.

[0028] The present invention provides an implant with a bionic anti-friction texture and a preparation method thereof; the preparation method comprises the following steps: placing a titanium alloy to be processed on a mobile platform of a femtosecond pulse laser processing system, and performing femtosecond pulse laser processing according to a pre-set bionic texture pattern to obtain an implant with a bionic anti-friction texture. Compared with the prior art, the preparation method provided by the present invention uses a femtosecond pulse laser to process a texture on the surface of a medical titanium alloy to form a bionic texture, which can reduce the contamination of impurity ions, reduce the generation of splashes and molten particles, and greatly improve the processing quality of the texture surface; and combined with bionic technology, a wavy bionic texture is designed on the surface of the material, which can reduce the generation of particles during wear and capture wear particles, thereby improving the stability of the titanium alloy during wear and reducing the amount of wear on the material surface; at the same time, no secondary surface treatment after texturing is required, and no other modification technology is required, thereby achieving an improvement in the wear resistance of the implant. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] FIG1 is a schematic structural diagram of a femtosecond pulse laser processing system used in an embodiment of the present invention;

[0030] FIG2 is a schematic diagram of a bionic structure design in Example 1 of the present invention;

[0031] FIG3 is a schematic diagram of the laser processing position in Example 1 of the present invention;

[0032] FIG4 is a topographic image of the bionic texture obtained in Example 1 of the present invention;

[0033] FIG5 is a topographical diagram of the wavy groove texture obtained in Example 1 of the present invention;

[0034] FIG6 is a topographical diagram of the wavy groove texture obtained in Example 2 of the present invention;

[0035] FIG7 is a topographical diagram of the wavy groove texture obtained in Example 3 of the present invention;

[0036] FIG8 is a topographical diagram of the wavy groove texture obtained in Example 4 of the present invention;

[0037] FIG9 is a topographical diagram of the wavy groove texture obtained in Example 5 of the present invention;

[0038] FIG10 is a topographical image of the wavy groove texture obtained in Example 6 of the present invention;

[0039] FIG11 is a topographical image of the wavy groove texture obtained in Example 7 of the present invention;

[0040] FIG12 is a topographical image of the wavy groove texture obtained in Example 8 of the present invention;

[0041] FIG13 is a cross-sectional comparison of the wear scars of the bionic texture obtained in Example 1 of the present invention and the titanium alloy surface without bionic texture processing;

[0042] FIG14 is a graph showing the results of a flow cytometry apoptosis experiment on the implant with a bionic anti-friction texture obtained in Example 1 of the present invention. DETAILED DESCRIPTION

[0043] The following will clearly and completely describe the technical solutions of the present invention in conjunction with the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0044] The present invention provides a method for preparing an implant having a bionic anti-friction texture, comprising the following steps:

[0045] The titanium alloy to be processed is placed on the mobile platform of the femtosecond pulse laser processing system, and femtosecond pulse laser processing is performed according to a pre-set bionic texture pattern to obtain an implant with a bionic wear-reducing texture.

[0046] At present, titanium alloys have the problem of high strength but poor wear resistance. Therefore, medical titanium alloys will produce wear during the implantation process, thereby reducing the stability of the implant; at the same time, the titanium metal implantation process will produce wear debris, and the metal ions will be toxic to the human body; and if the implant cannot be combined with the bone, it will cause bone dissolution, causing secondary damage to the human body; however, traditional surface strengthening technology will cause pollution to the implant and is not suitable for the strengthening and modification of the implant. In response to the above technical problems, the present invention provides a design for processing a wavy bionic anti-friction texture on the surface of medical titanium alloy based on a femtosecond pulse laser device. Ultrafast laser (Ultrafast laser) generally refers to a pulse width less than 10ps (1ps=10 -12 s); it has an extremely short pulse width and ultra-high peak power, and exhibits a strong nonlinear effect when interacting with materials, with minimal or even no thermal impact; ultrafast laser technology has the characteristics of wide material adaptability, high processing precision, micro-nano processing that breaks the diffraction limit, and "cold processing" with minimal thermal impact. It has developed rapidly in recent years and opened up a new research field of laser processing; the present invention takes bionic texture design as the blueprint, and uses ultrafast laser processing technology to construct a typical bionic texture on the surface of medical titanium alloy, achieving good control of the dimensional accuracy and structural integrity of the bionic texture.

[0047] The present invention uses a femtosecond pulse laser to process texture on the surface of medical titanium alloy to form a bionic texture (other processing methods such as electrochemistry, photolithography, wire cutting, etc. may also achieve texture processing, but due to processing accuracy and processing technology, the bionic texture of the present invention cannot be perfectly replicated and is far less fine than ultrafast laser processing). It can reduce the contamination of impurity ions, reduce the generation of spatter and molten particles, and greatly improve the texture surface processing quality; and combined with bionic technology, a wavy bionic texture is designed on the material surface, which can reduce the generation of particles during wear and capture wear particles, thereby improving the stability of titanium alloy during wear, and thus reducing the amount of wear on the material surface; at the same time, no secondary surface treatment after texturing is required, and no other modification technology is required, thereby achieving improved wear resistance of the implant.

[0048] The present invention first places the titanium alloy to be processed on the mobile platform of a femtosecond pulsed laser processing system. In the present invention, the titanium alloy to be processed is preferably selected from a Ti6Al4V titanium alloy substrate, a Ti5Al2.5Fe titanium alloy substrate, and a Ti6Al7Nb titanium alloy substrate, with a Ti6Al4V titanium alloy substrate being more preferred. The present invention does not particularly limit the source of the titanium alloy to be processed; commercially available sources of the aforementioned medical titanium alloys, known to those skilled in the art, can be used.

[0049] In the present invention, the titanium alloy to be processed is placed in front of the mobile platform, and preferably further comprises:

[0050] Ultrasonic cleaning of the titanium alloy to be processed in ethanol and / or water for 10 to 30 minutes;

[0051] More preferably:

[0052] The titanium alloy to be processed was ultrasonically cleaned in ethanol and deionized water for 20 minutes.

[0053] In the present invention, the femtosecond pulsed laser processing system preferably consists of a pulsed laser, an optical path system, a control system, and a mobile platform. The pulsed laser and optical path system are used to provide femtosecond pulsed laser light for titanium alloy surface processing; the control system is used to control the processing path to obtain a processed surface with a corresponding biomimetic texture pattern; and the mobile platform is used to adjust the laser focus on the material surface and the movement of the material. The present invention does not specifically limit the source of the femtosecond pulsed laser processing system; commercially available processing equipment equipped with a femtosecond pulsed laser, familiar to those skilled in the art, can be used.

[0054] Afterwards, the present invention performs femtosecond pulse laser processing according to a pre-set bionic texture pattern to obtain an implant with a bionic wear-reducing texture.

[0055] In the present invention, the bionic texture pattern is preferably composed of several wavy groove textures with anti-friction effect arranged at the same spacing; the wavy groove texture is preferably composed of a semicircle with a radius of 0.1mm to 0.3mm, more preferably 0.2mm; the spacing between two adjacent wavy groove textures is preferably 0.1mm to 0.3mm, more preferably 0.2mm.

[0056] In the present invention, the setting process of the bionic texture pattern is preferably as follows:

[0057] The shell surface texture was observed under microscope light, the shell surface morphology was extracted, the morphology map was designed using AutoCAD, and the wear resistance under different radius and spacing parameters was measured through a rotational friction experiment. The texture size with the radius and spacing parameters that had the best wear resistance was determined; then the texture pattern was saved in the def format, the laserDESK software of the control system in the femtosecond pulse laser processing system was opened, and the texture pattern file in the def format mentioned above was imported to complete the setting of the bionic texture map.

[0058] In the present invention, the femtosecond pulse laser processing process is preferably specifically as follows:

[0059] After completing the setting of the bionic texture pattern, set the pulse laser parameters of the femtosecond pulse laser processing system:

[0060] The first step is to set the number of scans and scanning speed of laser processing;

[0061] The second step is to set the laser average power and laser frequency;

[0062] The third step is to adjust the laser position;

[0063] Femtosecond pulse laser processing is then performed to form a wavy groove texture, ultimately obtaining an implant with a bionic wear-reducing texture.

[0064] In the present invention, the number of scans in the first step is preferably 20 to 40 times, more preferably 30 times, and the scanning speed is preferably 80 mm / s to 120 mm / s, more preferably 100 mm / s.

[0065] In the present invention, the average power of the laser in the second step is preferably 0.3W to 0.5W, more preferably 0.4W, and the laser frequency is preferably 0.8kHz to 1.2kHz, more preferably 1kHz.

[0066] In the present invention, the laser position is preferably adjusted by adjusting the z-axis position of the mobile platform of the femtosecond pulse laser processing system to be equal to the initial position plus the height of the titanium alloy to be processed, ensuring that the laser is focused on the material surface to improve processing quality and efficiency.

[0067] In the present invention, the beam quality of the femtosecond pulse laser processing is preferably M 2 =1 to 1.5, more preferably M 2 =1.2, the spot diameter in the experiment is preferably 30μm to 50μm, more preferably 40μm, the pulse width is preferably 250fs to 280fs, more preferably 268fs, and the wavelength is preferably 340nm to 350nm, more preferably 343nm.

[0068] The present invention also provides an implant with a biomimetic wear-reducing texture, produced using the preparation method described in the above technical solution. This preparation method utilizes ultrafast laser technology to achieve excellent control of the dimensional accuracy and structural integrity of the biomimetic texture without thermally impacting the material itself or introducing other impurities. Furthermore, the method incorporates bionics to produce a shell-like biomimetic wear-resistant texture on the surface of a titanium alloy.

[0069] The present invention provides an implant with a bionic anti-friction texture and a preparation method thereof; the preparation method comprises the following steps: placing a titanium alloy to be processed on a mobile platform of a femtosecond pulse laser processing system, and performing femtosecond pulse laser processing according to a pre-set bionic texture pattern to obtain an implant with a bionic anti-friction texture. Compared with the prior art, the preparation method provided by the present invention uses a femtosecond pulse laser to process a texture on the surface of a medical titanium alloy to form a bionic texture, which can reduce the contamination of impurity ions, reduce the generation of splashes and molten particles, and greatly improve the processing quality of the texture surface; and combined with bionic technology, a wavy bionic texture is designed on the surface of the material, which can reduce the generation of particles during wear and capture wear particles, thereby improving the stability of the titanium alloy during wear and reducing the amount of wear on the material surface; at the same time, no secondary surface treatment after texturing is required, and no other modification technology is required, thereby achieving an improvement in the wear resistance of the implant.

[0070] To further illustrate the present invention, the following examples are provided for detailed description. FIG1 shows a schematic diagram of the femtosecond pulsed laser processing system used in the following examples of the present invention. The system comprises a pulsed laser, an optical path system, a control system, and a mobile platform. The titanium alloy to be processed is a Ti6Al4V titanium alloy substrate.

[0071] Example 1

[0072] (1) Sample pretreatment: The titanium alloy to be processed was ultrasonically cleaned in ethanol and deionized water for 20 minutes.

[0073] (2) Texture pattern design: The shell surface texture was observed under microscope light, and the shell surface morphology was preliminarily extracted. The morphology was designed as shown in Figure 2 using AutoCAD. The wear resistance under different spacing parameters was measured through a rotational friction test, and it was finally determined that the texture size with a spacing of 0.2 mm had the best wear resistance.

[0074] (3) Processing process: The bionic structure shown in Figure 2 is made by CAD, and its wavy lines are composed of semicircles with a radius of 0.2 mm, and the distance between the lines is 0.2 mm; then the texture pattern is saved in the def format, the laserDESK software of the femtosecond laser system is opened, the def texture pattern file made by CAD is imported, and the laser parameters are set: the first step is to set the number of scans of laser processing to 30 times, and the scanning speed (v) is 150 mm / s; the second step is to set the average laser power to 0.4 W and the laser (pulse) frequency to 1 kHz; the third step is to adjust the laser position (to ensure that the laser is focused on the material surface to improve the processing quality and efficiency), measure the height h1 of the titanium alloy sample, and the initial laser focus position is h0. The z-axis position is adjusted by the motion stage of the femtosecond pulse laser processing system (the z-axis position is equal to the initial position plus the sample height), and the processing positioning is shown in Figure 3.

[0075] The beam quality of titanium alloy femtosecond pulse laser processing is M 2 =1.2, the spot diameter (Da) in the experiment is about 40 μm; the experimental parameters selected are pulse width 268 fs and wavelength 343 nm; the morphology of the obtained bionic texture is shown in Figure 4, and the morphology of the wavy groove texture is shown in Figure 5.

[0076] Example 2

[0077] The preparation method provided in Example 1 was used, except that: in the first step, the number of laser processing scans was set to 40 times, and the scanning speed (v) was 150 mm / s; the bionic texture morphology was obtained as shown in FIG6 .

[0078] Example 3

[0079] The preparation method provided in Example 1 was used, except that: in the first step, the number of laser processing scans was set to 50 times, and the scanning speed (v) was 150 mm / s; the bionic texture morphology was obtained as shown in FIG7 .

[0080] Example 4

[0081] The preparation method provided in Example 1 was used, except that: in the first step, the number of laser processing scans was set to 60 times, and the scanning speed (v) was 150 mm / s; the bionic texture morphology was obtained as shown in FIG8 .

[0082] Example 5

[0083] The preparation method provided in Example 1 was used, except that: in the first step, the number of laser processing scans was set to 30 times, and the scanning speed (v) was 100 mm / s; the bionic texture morphology was obtained as shown in FIG9 .

[0084] Example 6

[0085] The preparation method provided in Example 1 was used, except that: in the first step, the number of laser processing scans was set to 40 times, and the scanning speed (v) was 100 mm / s; the bionic texture morphology was obtained as shown in FIG10 .

[0086] Example 7

[0087] The preparation method provided in Example 1 was used, except that: in the first step, the number of laser processing scans was set to 50 times, and the scanning speed (v) was 100 mm / s; the bionic texture morphology was obtained as shown in FIG11 .

[0088] Example 8

[0089] The preparation method provided in Example 1 was adopted, except that: in the first step, the number of laser processing scans was set to 60 times, and the scanning speed (v) was 100 mm / s; the bionic texture morphology was obtained as shown in FIG12 .

[0090] By comparison, Figure 9 shows the best effect.

[0091] The titanium alloy surface with bionic anti-friction texture obtained in Example 1 was compared with the titanium alloy surface without bionic texture processing:

[0092] The friction and wear performance of the bionic texture was investigated through friction and wear experiments, and the results are shown in Figure 13. Compared with the untextured surface, the wear of the 0.2 mm bionic texture was reduced by 73%, and its tribological performance was greatly improved.

[0093] The biomimetic wear-reducing textured implants obtained in Example 1 were subjected to in vitro cell experiments. The results are shown in Figure 14, which shows (a) the flow cytometry results of the original sample and (b) the flow cytometry results of the textured sample. The figure is divided into four regions: Q1 represents the percentage of necrotic cells, Q2 represents the percentage of late apoptotic cells, Q3 represents the percentage of early apoptotic cells, and Q4 represents the percentage of non-apoptotic cells. The experimental results show that laser treatment does not have a toxic effect on the material itself, and the micro-nanostructures generated on its surface enhance cell attachment and differentiation, promoting cell proliferation.

[0094] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A method for preparing an implant with a bionic anti-friction texture, characterized in that: The following steps are involved: The titanium alloy to be processed is placed on the mobile platform of the femtosecond pulse laser processing system, and femtosecond pulse laser processing is performed according to a pre-set bionic texture pattern to obtain an implant with a bionic wear-reducing texture.

2. The preparation method according to claim 1, characterized in that: The titanium alloy to be processed is selected from a Ti6Al4V titanium alloy substrate, a Ti5Al2.5Fe titanium alloy substrate and a Ti6Al7Nb titanium alloy substrate.

3. The preparation method according to claim 1, characterized in that: The titanium alloy to be processed is placed in front of the mobile platform, and further comprises: The titanium alloy to be processed is ultrasonically cleaned in ethanol and / or water for 10 minutes to 30 minutes.

4. The preparation method according to claim 1, characterized in that: The femtosecond pulse laser processing system is composed of a pulse laser, an optical path system, a control system and a moving platform.

5. The preparation method according to claim 1, characterized in that: The bionic texture pattern is composed of a plurality of wavy groove textures with anti-friction effect arranged at the same interval; the wavy groove texture is composed of a semicircle with a radius of 0.1mm to 0.3mm, and the interval between two adjacent wavy groove textures is 0.1mm to 0.3mm.

6. The preparation method according to claim 1, characterized in that: The setting process of the bionic texture pattern is specifically as follows: The shell surface texture was observed through microscope light, the shell surface morphology was extracted, the morphology diagram was designed through AutoCAD, and then the wear resistance under different radius and spacing parameters was measured through rotational friction experiment, and the texture size with radius and spacing parameters with the best wear resistance was determined; then the texture pattern was saved in def format, the laserDESK software of the control system in the femtosecond pulse laser processing system was opened, and the texture pattern file in the def format mentioned above was imported to complete the setting of the bionic texture diagram.

7. The preparation method according to claim 1, characterized in that: The femtosecond pulse laser processing process is specifically as follows: After completing the setting of the bionic texture pattern, set the pulse laser parameters of the femtosecond pulse laser processing system: The first step is to set the number of scans and scanning speed of laser processing; The second step is to set the average laser power and laser frequency; The third step is to adjust the laser position; Femtosecond pulse laser processing is then performed to form a wavy groove texture, ultimately obtaining an implant with a bionic wear-reducing texture.

8. The preparation method according to claim 7, characterized in that: The scanning times are 20 to 40 times, and the scanning speed is 80 mm / s to 120 mm / s; The average power of the laser is 0.3W to 0.5W, and the laser frequency is 0.8kHz to 1.2kHz; The laser position is adjusted by adjusting the z-axis position of the mobile platform of the femtosecond pulse laser processing system to be equal to the initial position plus the height of the titanium alloy to be processed.

9. The preparation method according to claim 1, characterized in that: The beam quality of the femtosecond pulse laser processing is M 2 =1~1.5, the spot diameter in the experiment is 30μm~50μm, the pulse width is 250fs~280fs, and the wavelength is 340nm~350nm.

10. An implant with a bionic anti-friction texture, characterized in that: The preparation method is described in any one of claims 1 to 9.

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